Pub Date : 2023-11-30DOI: 10.2967/jnumed.123.266061
Jie Ding, Xiang Li, Shengyan Liu, Yinjie Gao, Guoyang Zheng, Marcus Hacker, Yushi Zhang, Anli Tong, Li Huo
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{"title":"Clinical Value of 68Ga-Pentixafor PET/CT in Subtype Diagnosis of Primary Aldosteronism Patients with Adrenal Micronodules","authors":"Jie Ding, Xiang Li, Shengyan Liu, Yinjie Gao, Guoyang Zheng, Marcus Hacker, Yushi Zhang, Anli Tong, Li Huo","doi":"10.2967/jnumed.123.266061","DOIUrl":"https://doi.org/10.2967/jnumed.123.266061","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266061absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138469036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-30DOI: 10.2967/jnumed.123.266164
Louise Emmett, Nathan Papa, William Counter, Jeremie Calais, Francesco Barbato, Irene Burger, Matthias Eiber, Matthew J. Roberts, Shikha Agrawal, Anthony Franklin, Alan Xue, Krishan Rasiah, Nikeith John, Daniel Moon, Mark Frydenberg, John Yaxley, Phillip Stricker, Keith Wong, Geoff Coughlin, Troy Gianduzzo, Boon Kua, Bao Ho, Andrew Nguyen, Victor Liu, Jonathan Lee, Edward Hsiao, Tom Sutherland, Elisa Perry, Wolfgang P. Fendler, Thomas A. Hope
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{"title":"Reproducibility and Accuracy of the PRIMARY Score on PSMA PET and of PI-RADS on Multiparametric MRI for Prostate Cancer Diagnosis Within a Real-World Database","authors":"Louise Emmett, Nathan Papa, William Counter, Jeremie Calais, Francesco Barbato, Irene Burger, Matthias Eiber, Matthew J. Roberts, Shikha Agrawal, Anthony Franklin, Alan Xue, Krishan Rasiah, Nikeith John, Daniel Moon, Mark Frydenberg, John Yaxley, Phillip Stricker, Keith Wong, Geoff Coughlin, Troy Gianduzzo, Boon Kua, Bao Ho, Andrew Nguyen, Victor Liu, Jonathan Lee, Edward Hsiao, Tom Sutherland, Elisa Perry, Wolfgang P. Fendler, Thomas A. Hope","doi":"10.2967/jnumed.123.266164","DOIUrl":"https://doi.org/10.2967/jnumed.123.266164","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266164absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138468908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-30DOI: 10.2967/jnumed.123.266208
Keiichiro Kuronuma, Chih-Chun Wei, Ananya Singh, Mark Lemley, Sean W. Hayes, Yuka Otaki, Mark C. Hyun, Serge D. Van Kriekinge, Paul Kavanagh, Cathleen Huang, Donghee Han, Damini Dey, Daniel S. Berman, Piotr J. Slomka
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{"title":"Automated Motion Correction for Myocardial Blood Flow Measurements and Diagnostic Performance of 82Rb PET Myocardial Perfusion Imaging","authors":"Keiichiro Kuronuma, Chih-Chun Wei, Ananya Singh, Mark Lemley, Sean W. Hayes, Yuka Otaki, Mark C. Hyun, Serge D. Van Kriekinge, Paul Kavanagh, Cathleen Huang, Donghee Han, Damini Dey, Daniel S. Berman, Piotr J. Slomka","doi":"10.2967/jnumed.123.266208","DOIUrl":"https://doi.org/10.2967/jnumed.123.266208","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266208absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138468971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-30DOI: 10.2967/jnumed.123.265931
Elena Doering, Georgios Antonopoulos, Merle Hoenig, Thilo van Eimeren, Marcel Daamen, Henning Boecker, Frank Jessen, Emrah Düzel, Simon Eickhoff, Kaustubh Patil, Alexander Drzezga
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{"title":"MRI or 18F-FDG PET for Brain Age Gap Estimation: Links to Cognition, Pathology, and Alzheimer Disease Progression","authors":"Elena Doering, Georgios Antonopoulos, Merle Hoenig, Thilo van Eimeren, Marcel Daamen, Henning Boecker, Frank Jessen, Emrah Düzel, Simon Eickhoff, Kaustubh Patil, Alexander Drzezga","doi":"10.2967/jnumed.123.265931","DOIUrl":"https://doi.org/10.2967/jnumed.123.265931","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.265931absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138468923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-30DOI: 10.2967/jnumed.123.266345
Sarah E. Poplawski, Robin M. Hallett, Mark H. Dornan, Kyle E. Novakowski, Shuang Pan, Anthony P. Belanger, Quang-De Nguyen, Wengen Wu, Albert E. Felten, Yuxin Liu, Shin Hye Ahn, Valerie S. Hergott, Barry Jones, Jack H. Lai, Joe A.B. McCann, William W. Bachovchin
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{"title":"Preclinical Development of PNT6555, a Boronic Acid–Based, Fibroblast Activation Protein-α (FAP)–Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors","authors":"Sarah E. Poplawski, Robin M. Hallett, Mark H. Dornan, Kyle E. Novakowski, Shuang Pan, Anthony P. Belanger, Quang-De Nguyen, Wengen Wu, Albert E. Felten, Yuxin Liu, Shin Hye Ahn, Valerie S. Hergott, Barry Jones, Jack H. Lai, Joe A.B. McCann, William W. Bachovchin","doi":"10.2967/jnumed.123.266345","DOIUrl":"https://doi.org/10.2967/jnumed.123.266345","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266345absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138468970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-30DOI: 10.2967/jnumed.123.266005
Felicia Wang, Chen Liu, Igor Vidal, Margarita Mana-Ay, Andrew F. Voter, Lilja B. Solnes, Ashley E. Ross, Andrei Gafita, Edward M. Schaeffer, Trinity J. Bivalacqua, Kenneth J. Pienta, Martin G. Pomper, Martin A. Lodge, Daniel Y. Song, Jorge D. Oldan, Mohamad E. Allaf, Angelo M. De Marzo, Sara Sheikhbahaei, Michael A. Gorin, Steven P. Rowe
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{"title":"Comparison of Multiple Segmentation Methods for Volumetric Delineation of Primary Prostate Cancer with Prostate-Specific Membrane Antigen–Targeted 18F-DCFPyL PET/CT","authors":"Felicia Wang, Chen Liu, Igor Vidal, Margarita Mana-Ay, Andrew F. Voter, Lilja B. Solnes, Ashley E. Ross, Andrei Gafita, Edward M. Schaeffer, Trinity J. Bivalacqua, Kenneth J. Pienta, Martin G. Pomper, Martin A. Lodge, Daniel Y. Song, Jorge D. Oldan, Mohamad E. Allaf, Angelo M. De Marzo, Sara Sheikhbahaei, Michael A. Gorin, Steven P. Rowe","doi":"10.2967/jnumed.123.266005","DOIUrl":"https://doi.org/10.2967/jnumed.123.266005","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266005absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138468922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-30DOI: 10.2967/jnumed.123.266158
Kilian Kluge, Holger Einspieler, David Haberl, Clemens Spielvogel, Stefan Stoiber, Chrysoula Vraka, Laszlo Papp, Sabine Wunsch, Gerda Egger, Gero Kramer, Bernhard Grubmüller, Shahrokh Shariat, Marcus Hacker, Lukas Kenner, Alexander Haug
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{"title":"Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective–Prospective [68Ga]Ga-PSMA-11 PET/CT Study","authors":"Kilian Kluge, Holger Einspieler, David Haberl, Clemens Spielvogel, Stefan Stoiber, Chrysoula Vraka, Laszlo Papp, Sabine Wunsch, Gerda Egger, Gero Kramer, Bernhard Grubmüller, Shahrokh Shariat, Marcus Hacker, Lukas Kenner, Alexander Haug","doi":"10.2967/jnumed.123.266158","DOIUrl":"https://doi.org/10.2967/jnumed.123.266158","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266158absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138468972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-08DOI: 10.2967/jnumed.122.264788
A. Alavi
{"title":"Nuclear Medicine: The Essentials","authors":"A. Alavi","doi":"10.2967/jnumed.122.264788","DOIUrl":"https://doi.org/10.2967/jnumed.122.264788","url":null,"abstract":"","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90509206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-16DOI: 10.2967/jnumed.122.264168
Angela C. Rieger, D. Silverman
This work is supported by National Institutes of Health (NIH) grants P50 AG016574, U01 AG006786, R37 AG11378, R01 AG054449, R01 AG041851, R01 AG011378, R01 AG034676, R01 AG37491, and R01 NS097495; the Robert Wood Johnson Foundation; the Elsie and Marvin Dekelboum Family Foundation; the Liston Family Foundation; the Robert H. and Clarice Smith and Abigail van Buren Alzheimer Disease Research Program; the Gerald and Henrietta Rauenhorst Foundation; Foundation Dr. Corinne Schuler (Geneva, Switzerland); the Alexander Family Alzheimer Disease Research Professorship of the Mayo Clinic, and the Mayo Foundation for Medical Education and Research. No other potential conflict of interest relevant to this article was reported.
{"title":"Reply: Posterior Cingulate Involvement Does Not Argue Against LATE—And Who Said It Does?","authors":"Angela C. Rieger, D. Silverman","doi":"10.2967/jnumed.122.264168","DOIUrl":"https://doi.org/10.2967/jnumed.122.264168","url":null,"abstract":"This work is supported by National Institutes of Health (NIH) grants P50 AG016574, U01 AG006786, R37 AG11378, R01 AG054449, R01 AG041851, R01 AG011378, R01 AG034676, R01 AG37491, and R01 NS097495; the Robert Wood Johnson Foundation; the Elsie and Marvin Dekelboum Family Foundation; the Liston Family Foundation; the Robert H. and Clarice Smith and Abigail van Buren Alzheimer Disease Research Program; the Gerald and Henrietta Rauenhorst Foundation; Foundation Dr. Corinne Schuler (Geneva, Switzerland); the Alexander Family Alzheimer Disease Research Professorship of the Mayo Clinic, and the Mayo Foundation for Medical Education and Research. No other potential conflict of interest relevant to this article was reported.","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87260506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.2967/jnumed.121.262413
O. Sartor, K. Herrmann
The phase III VISION trial using 177Lu-PSMA-617 has significant implications for the field of theranostics and broad repercussions for the clinical management of prostate cancer. Metastatic prostate cancer is a rapidly evolving field with a complex landscape that has multiple established therapies, including chemotherapies, hormonal therapies, immunotherapies, radiopharmaceuticals, and targeted therapies. The current landscape was created by an important series of pivotal phase III trials, typically with an overall-survival endpoint. To best understand the VISION trial (performed on patients with metastatic castration-resistant prostate cancer), it is essential to have a thorough understanding of the key decisions that underpinned the design, as well as the context of those decisions. Here, we describe critical elements of the VISION phase III trial and how those elements will shape regulatory decision making and clinic practice. Inclusion and exclusion criteria were carefully crafted, as were treatments, assessments, and endpoints. The results of the VISION trial were impressive, with clear improvements in survival for patients having few treatment alternatives. Besides the significant progress, there are also significant limitations. 177Lu-PSMA-617 treatments will have far-reaching implications for prostate cancer. Food and Drug Administration approval was granted March 23, 2022, on the basis of the VISION data.
{"title":"Prostate Cancer Treatment: 177Lu-PSMA-617 Considerations, Concepts, and Limitations","authors":"O. Sartor, K. Herrmann","doi":"10.2967/jnumed.121.262413","DOIUrl":"https://doi.org/10.2967/jnumed.121.262413","url":null,"abstract":"The phase III VISION trial using 177Lu-PSMA-617 has significant implications for the field of theranostics and broad repercussions for the clinical management of prostate cancer. Metastatic prostate cancer is a rapidly evolving field with a complex landscape that has multiple established therapies, including chemotherapies, hormonal therapies, immunotherapies, radiopharmaceuticals, and targeted therapies. The current landscape was created by an important series of pivotal phase III trials, typically with an overall-survival endpoint. To best understand the VISION trial (performed on patients with metastatic castration-resistant prostate cancer), it is essential to have a thorough understanding of the key decisions that underpinned the design, as well as the context of those decisions. Here, we describe critical elements of the VISION phase III trial and how those elements will shape regulatory decision making and clinic practice. Inclusion and exclusion criteria were carefully crafted, as were treatments, assessments, and endpoints. The results of the VISION trial were impressive, with clear improvements in survival for patients having few treatment alternatives. Besides the significant progress, there are also significant limitations. 177Lu-PSMA-617 treatments will have far-reaching implications for prostate cancer. Food and Drug Administration approval was granted March 23, 2022, on the basis of the VISION data.","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87636742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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