1. Diet, Ketogenic 2. Metabolism 3. Epilepsy Introduction: Epilepsy has been considered a chronic brain disorder, which affects almos t1% of the world population. Among this population, about a third of epilepsy patients are considered as the drug-resis tant group who are not responsive to anti-epileptic medicaments. The ketogenic diet has been defined as a diet containing high fat, low carbohydrate, and limited protein. The ketogenic diet has a subs tantial effect on body metabolism in a way that body and brain would utilize ketone bodies ins tead of glucose. Fundamentally, this diet helps some patients who are resis tant to anticonvulsant drugs. Conclusion: Maintaining this diet for a long time causes a positive effect and has a much more efficient impact on children rather than adults, but it could lead to some adverse effects, including renal s tone, bone fracture, and hypercholes terolemia. In this s tudy, we reviewed the relationship between ketogenic diet and epilepsy disorder and discussed the potential mechanisms of action. ABSTRACT Article Info:
{"title":"The Anticonvulsant Effect of the Ketogenic Diet in the Treatment of Epilepsy","authors":"F. Yaghoubi, Maryam Jafarian, A. Gorji","doi":"10.52547/shefa.9.1.200","DOIUrl":"https://doi.org/10.52547/shefa.9.1.200","url":null,"abstract":"1. Diet, Ketogenic 2. Metabolism 3. Epilepsy Introduction: Epilepsy has been considered a chronic brain disorder, which affects almos t1% of the world population. Among this population, about a third of epilepsy patients are considered as the drug-resis tant group who are not responsive to anti-epileptic medicaments. The ketogenic diet has been defined as a diet containing high fat, low carbohydrate, and limited protein. The ketogenic diet has a subs tantial effect on body metabolism in a way that body and brain would utilize ketone bodies ins tead of glucose. Fundamentally, this diet helps some patients who are resis tant to anticonvulsant drugs. Conclusion: Maintaining this diet for a long time causes a positive effect and has a much more efficient impact on children rather than adults, but it could lead to some adverse effects, including renal s tone, bone fracture, and hypercholes terolemia. In this s tudy, we reviewed the relationship between ketogenic diet and epilepsy disorder and discussed the potential mechanisms of action. ABSTRACT Article Info:","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"164 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78072896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Sedghigoyaghaj, Zahra Seidi, Zahra Darvishi, F. Mokhtari
neglected. This s tudy aimed to determine health literacy in veterans with spinal cord injury referred to Khatam Hospital, Iran. Materials and Methods: This s tudy was a descriptive-analytical cross-sectional s tudy. All veterans with paraplegia following spinal cord injury, who were referred to Khatam Alanbia Hospital in 2018 were our s tatis tical research community. 200 veterans were selected and examined through the purposive sampling method based on inclusion criteria. Demographic characteris tics of veterans and Iranian adult health literacy ques tionnaires were used to collect data. Results: The overall health literacy score was inadequate in 38% of the veterans. The mean score of health literacy was 51.4 ± 8.8. The aspect of access to health literacy promotion resources received the highes t score and there was a significant relationship between health literacy, education, and occupation. Conclusion: The data revealed that the level of health literacy of veterans with spinal cord injury is not desirable. Improving health literacy in these patients reduces the complications and promotes self-care behaviors.
{"title":"Health Literacy in Veterans with Spinal Cord Injury Referred to Khatam Alanbia Hospital, Tehran, Iran","authors":"N. Sedghigoyaghaj, Zahra Seidi, Zahra Darvishi, F. Mokhtari","doi":"10.52547/shefa.9.1.131","DOIUrl":"https://doi.org/10.52547/shefa.9.1.131","url":null,"abstract":"neglected. This s tudy aimed to determine health literacy in veterans with spinal cord injury referred to Khatam Hospital, Iran. Materials and Methods: This s tudy was a descriptive-analytical cross-sectional s tudy. All veterans with paraplegia following spinal cord injury, who were referred to Khatam Alanbia Hospital in 2018 were our s tatis tical research community. 200 veterans were selected and examined through the purposive sampling method based on inclusion criteria. Demographic characteris tics of veterans and Iranian adult health literacy ques tionnaires were used to collect data. Results: The overall health literacy score was inadequate in 38% of the veterans. The mean score of health literacy was 51.4 ± 8.8. The aspect of access to health literacy promotion resources received the highes t score and there was a significant relationship between health literacy, education, and occupation. Conclusion: The data revealed that the level of health literacy of veterans with spinal cord injury is not desirable. Improving health literacy in these patients reduces the complications and promotes self-care behaviors.","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"59 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77760556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
frequency domains feature in every s timulation type were extracted from ERP components. Correlation between percentage changes and the subject’s IVA tes t results were calculated before and after applying tDCS. Results: The result showed that Beta energy significantly increased after applying tDCS. Furthermore, a significant correlation was observed between beta energy and auditory omission error in FP1 channel. Conclusion: tDCS decreases omission error and increases beta energy in auditory s timulation, which then leads to the improvement of focus attention. Further s tudies are needed to assess the effect of tDCS on the improvement of attention in auditory attention deficit.
{"title":"Assessment of the Effect of Transcranial Direct Current Stimulations (tDCS) in Focused Attention Enhancement Using Event-Related Potentials","authors":"Shokoufeh Moezzi, M. Ghoshuni, M. Amiri","doi":"10.52547/shefa.9.1.25","DOIUrl":"https://doi.org/10.52547/shefa.9.1.25","url":null,"abstract":"frequency domains feature in every s timulation type were extracted from ERP components. Correlation between percentage changes and the subject’s IVA tes t results were calculated before and after applying tDCS. Results: The result showed that Beta energy significantly increased after applying tDCS. Furthermore, a significant correlation was observed between beta energy and auditory omission error in FP1 channel. Conclusion: tDCS decreases omission error and increases beta energy in auditory s timulation, which then leads to the improvement of focus attention. Further s tudies are needed to assess the effect of tDCS on the improvement of attention in auditory attention deficit.","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79478111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
1. Alzheimer Disease 2. Calcium Channel Blockers 3. Therapeuticse Introduction: Alzheimer’s disease (AD) is the mos t common type of dementia in the elderly. Memory impairment usually occurs gradually and progressively. AD has not only been associated with decreased cerebral acetylcholine concentration, oxidative s tress, and beta-amyloid protein deposition, but more recent s tudies have shown that neurodegeneration induced by dis turbance of the intracellular calcium homeos tasis is also involved in the pathophysiology of the disease. It has been reported that calcium channel blockers (CCBs) have beneficial effects in different models of memory impairment. Here, we review and discuss the effects of CCBs, especially N-types, as novel agents that have effects on memory deficits in animal models of AD. on contrary to the L-type calcium channels, which are presented in the other organs in addition to nerve cells, N-type calcium channels are commonly located on the neurons. The main advantage of N-type CCBs is their lower side effects than other CCBs. Conclusion: Targeting the N-type CCBs may contribute to the new s trategies for the treatment of AD. ABSTRACT Article Info:
{"title":"Calcium Channel Blockers: New Therapeutic Targets for Alzheimer's Disease","authors":"H. Bozorgi, Hamed Darbanian","doi":"10.52547/shefa.9.1.1","DOIUrl":"https://doi.org/10.52547/shefa.9.1.1","url":null,"abstract":"1. Alzheimer Disease 2. Calcium Channel Blockers 3. Therapeuticse Introduction: Alzheimer’s disease (AD) is the mos t common type of dementia in the elderly. Memory impairment usually occurs gradually and progressively. AD has not only been associated with decreased cerebral acetylcholine concentration, oxidative s tress, and beta-amyloid protein deposition, but more recent s tudies have shown that neurodegeneration induced by dis turbance of the intracellular calcium homeos tasis is also involved in the pathophysiology of the disease. It has been reported that calcium channel blockers (CCBs) have beneficial effects in different models of memory impairment. Here, we review and discuss the effects of CCBs, especially N-types, as novel agents that have effects on memory deficits in animal models of AD. on contrary to the L-type calcium channels, which are presented in the other organs in addition to nerve cells, N-type calcium channels are commonly located on the neurons. The main advantage of N-type CCBs is their lower side effects than other CCBs. Conclusion: Targeting the N-type CCBs may contribute to the new s trategies for the treatment of AD. ABSTRACT Article Info:","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"244 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83563133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epileptic Seizure Prediction from Spectral, Temporal, and Spatial Features of EEG Signals Using Deep Learning Algorithms","authors":"Nazanin Mohammadkhani Ghiasvand, Foad Ghaderi","doi":"10.52547/shefa.9.1.110","DOIUrl":"https://doi.org/10.52547/shefa.9.1.110","url":null,"abstract":"*Corresponding Author: Foad Ghaderi E-mail: fghaderi@modares.ac.ir","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76965285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Ghadiri, Younes Mosadegh, Mohammad Alghosi, Zahra Golzari
the of on time of the phase of with and with a of ± selected the Participants performed two different cognitive tasks while walking on the Foot Medisense machine and the timing of the s tance-phase was measured. Results: The results showed no significant difference between the intra-group factors in the right and left heel s trike phase. However, the foot flat phase, mid-s tance phase, heel-off, and toe-off phase in the right and left heel s trike phase have shown significant differences. Furthermore, a significant difference between intra-group factors for the left and right leg was observed. Conclusion: Our data indicate that the evaluation of the s tance-phase could be used for the assessment of motor function in children with Down syndrome.
{"title":"The Effect of Secondary Cognitive Task on Time of the Stance Phase of People with Down Syndrome","authors":"F. Ghadiri, Younes Mosadegh, Mohammad Alghosi, Zahra Golzari","doi":"10.52547/shefa.9.1.36","DOIUrl":"https://doi.org/10.52547/shefa.9.1.36","url":null,"abstract":"the of on time of the phase of with and with a of ± selected the Participants performed two different cognitive tasks while walking on the Foot Medisense machine and the timing of the s tance-phase was measured. Results: The results showed no significant difference between the intra-group factors in the right and left heel s trike phase. However, the foot flat phase, mid-s tance phase, heel-off, and toe-off phase in the right and left heel s trike phase have shown significant differences. Furthermore, a significant difference between intra-group factors for the left and right leg was observed. Conclusion: Our data indicate that the evaluation of the s tance-phase could be used for the assessment of motor function in children with Down syndrome.","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82097458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Key Role of Macrophages and Monocytes in Spinal Cord Injury: Development of Novel Therapeutic Approaches","authors":"M. Javdani, Abolfazl Barzegar-Bafrouei","doi":"10.29252/shefa.8.4.90","DOIUrl":"https://doi.org/10.29252/shefa.8.4.90","url":null,"abstract":"*Corresponding Author: Moosa Javdani E-mail: Javdani59@gmail.com","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90961626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship Between Pupil Diameter Data and Confidence in Multi-Stage Decisions","authors":"S. Vafaei, R. Ebrahimpour, Sajjad Zabbah","doi":"10.29252/shefa.8.4.70","DOIUrl":"https://doi.org/10.29252/shefa.8.4.70","url":null,"abstract":"*Corresponding Author: Reza Ebrahimpour E-mail: rebrahimpour@srttu.edu","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77137132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryam Bidadian, K. R. Tabatabaei, A. Moghadasi, F. Ahmadi
intolerance of ambiguity. Conclusion: Outcomes revealed antecedent factors of the transition to secondary progressive MS is based on core beliefs. Furthermore, personality traits are complex, inclusive, and multi-dimensional factors.
{"title":"Exploring the Psychological Antecedent Factors of the Transition to Secondary Progressive Multiple Sclerosis: A Qualitative Study","authors":"Maryam Bidadian, K. R. Tabatabaei, A. Moghadasi, F. Ahmadi","doi":"10.29252/shefa.8.4.29","DOIUrl":"https://doi.org/10.29252/shefa.8.4.29","url":null,"abstract":"intolerance of ambiguity. Conclusion: Outcomes revealed antecedent factors of the transition to secondary progressive MS is based on core beliefs. Furthermore, personality traits are complex, inclusive, and multi-dimensional factors.","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"223 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79720104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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