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Collagenous gastritis presenting as chronic heartburn in a patient with psoriatic arthritis 银屑病关节炎患者的胶原性胃炎表现为慢性胃灼热
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1105
A. Deb, B. Songtanin, Thanita Thongtan, Sameer R Islam
Collagenous gastritis is a rare cause of heartburn in adults. Histopathological examination of gastric mucosal biopsy from the stomach shows submucosal collagen deposition. The pathophysiologic mechanism is unknown, and collagenous gastritis cases have been associated with certain drugs, such as olmesartan and non-steroidal anti-inflammatory drugs, and certain medical conditions, such as common variable immunodeficiency, primary IgM deficiency, autoimmune disorders, and psoriatic arthropathy. Here we report a case of collagenous gastritis in a 29-year-old woman with psoriatic arthropathy who presented with persistent heartburn. She was successfully treated with oral pantoprazole.   Key words: heartburn, collagenous gastritis,
胶原性胃炎是成人胃灼热的罕见原因。胃粘膜活检的组织病理学检查显示粘膜下胶原沉积。其病理生理机制尚不清楚,胶原性胃炎病例与某些药物,如奥美沙坦和非甾体抗炎药,以及某些医疗条件,如常见可变免疫缺陷,原发性IgM缺乏,自身免疫性疾病和银屑病关节病有关。在此,我们报告一例胶原性胃炎,在一个29岁的女性银屑病关节病谁提出了持续的胃灼热。她口服泮托拉唑治疗成功。关键词:胃灼热;胶原性胃炎;
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引用次数: 0
Assessing and addressing COVID-19 vaccine hesitancy in a West Texas Free Clinic through motivational interview-guided intervention 通过动机性访谈引导干预评估和解决西德克萨斯州免费诊所COVID-19疫苗犹豫问题
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1071
Esere A Nesiama, Rachel Vopni, Nayeli Fuentes, Fiona R. Prabhu, Kelly Bennett
Background Vaccine hesitancy is a public health issue that threatens successful prevention of vaccine-preventable diseases. The Free Clinic at Lubbock Impact serves rural, West Texas uninsured patients. In recognition of low vaccination rates among this population, an initiative was undertaken to better understand factors contributing to COVID-19 vaccine reluctance and conduct interventions to reduce hesitancy. Methodology Patients at the Free Clinic between January 2022 and March 2022 received a voluntary survey regarding their COVID-19 vaccination status, perceived barriers to vaccination, and factors influencing vaccination status with Likert-scale response options. Following the first 3 weeks of data collection, an educational intervention was designed and implemented for unvaccinated participants. The intervention included a motivational interview, pamphlet review, and exit survey to assess future likelihood of vaccination. Results   A total of 161 survey responses were obtained from the initial survey with a total unique patient population of 138. Of the 138 unique patients surveyed, 73 reported as vaccinated and 65 reported as not vaccinated against COVID-19. For hesitancy factors among unvaccinated participants, the mode for the “Extremely Important” hesitancy factor was “Personal Preference”.   37 of the 41 unvaccinated participants who received an intervention reported liking the discussion of the COVID-19 vaccine (90.2%), 4 reported they were not interested (9.8%), and 0 reported disliking the intervention. Half of the respondents indicated an increased likelihood of future vaccination.   Conclusion The goal of reducing vaccine hesitancy at The Free Clinic was successful. These findings support the benefits of openness to educational interventions among vulnerable populations.    
疫苗犹豫是一个公共卫生问题,威胁到疫苗可预防疾病的成功预防。拉伯克影响的免费诊所服务于德克萨斯州西部农村地区没有保险的病人。认识到这一人群的疫苗接种率较低,开展了一项倡议,以更好地了解导致不愿接种COVID-19疫苗的因素,并开展干预措施以减少犹豫。方法2022年1月至2022年3月期间,免费诊所的患者接受了一项自愿调查,内容包括他们的COVID-19疫苗接种状况、疫苗接种的感知障碍以及影响疫苗接种状况的因素。在收集数据的前三周后,对未接种疫苗的参与者设计并实施了教育干预。干预措施包括动机访谈、小册子审查和出口调查,以评估未来接种疫苗的可能性。结果从初始调查中获得了161个调查回复,总共有138个独特的患者群体。在接受调查的138名独特患者中,73人报告接种了COVID-19疫苗,65人报告未接种疫苗。对于未接种疫苗的参与者的犹豫因素,“极其重要”犹豫因素的模型为“个人偏好”。41名接受干预的未接种疫苗的参与者中有37人报告喜欢COVID-19疫苗的讨论(90.2%),4人报告不感兴趣(9.8%),0人报告不喜欢干预。半数答复者表示今后接种疫苗的可能性增加。结论自由诊所减少疫苗犹豫的目标是成功的。这些发现支持对弱势群体开放教育干预的好处。
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引用次数: 1
Left ventricular outflow tract pseudoaneurysms and severe paravalvular aortic regurgitation treated by percutaneous approach in a Marfan syndrome patient 经皮入路治疗1例马凡氏综合征患者左心室流出道假性动脉瘤及严重瓣旁主动脉反流
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1081
D. Paz, Timothy W. Hegeman, Onur Varli, C. Çevik
A 66-year-old male with a history of Marfan syndrome and resolved infective endocarditis was found to have shortness of breath after a previous aortic valve replacement in 2010. Several severe paravalvular leaks were seen on imaging, and left ventricular outflow tract pseudoaneurysms were identified as the cause of his symptoms which warranted treatment. Due to this patient’s risk of surgical intervention, a retrograde transaortic approach was used.
66岁男性,马凡氏综合征病史,感染性心内膜炎消退,2010年行主动脉瓣置换术后发现呼吸短促。影像学上发现了几个严重的瓣旁渗漏,左心室流出道假性动脉瘤被确定为引起他症状的原因,需要治疗。由于该患者有手术介入的风险,我们采用逆行经主动脉入路。
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引用次数: 0
COVID-19 induced pulmonary artery aneurysm COVID-19诱导的肺动脉动脉瘤
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1097
T. Singh, Ricardo Franco, B. Kakarala, Andres Yepes Hurtado
A 56-year-old man with a recent COVID 19 pneumonia presented to the emergency center with cough, hemoptysis, and increasing dyspnea. The patient deteriorated rapidly and was intubated for respiratory failure. Vital signs showed a temperature of 97.8°F, a heart rate of 113 beats/minute, and blood pressure of 107/85 mmHg while on mechanical ventilation. The endotracheal tube was filled with blood. A bedside bronchoscopy showed blood clots in and fresh blood oozing from the right mainstem bronchus. Based on the clinical feature of hemoptysis and a chest radiograph showing right lower and middle lobe consolidation with pleural effusion, the differential diagnosis includes necrotizing pneumonia and alveolar hemorrhage. His history of COVID 19 made pulmonary artery embolism a possibility.
一名56岁男性,近期感染COVID - 19肺炎,以咳嗽、咯血和呼吸困难加重就诊于急救中心。病人病情迅速恶化,因呼吸衰竭而插管。在机械通气时,生命体征显示体温97.8°F,心率113次/分钟,血压107/85 mmHg。气管内管充满了血。床边支气管镜检查显示血凝块和新鲜血液从右主支气管渗出。根据咯血的临床特征和胸片显示右下叶和中叶实变伴胸腔积液,鉴别诊断包括坏死性肺炎和肺泡出血。他的新冠肺炎病史使他有可能发生肺动脉栓塞。
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引用次数: 0
Clinical effectiveness of generic vancomycin products compared to Vancocin CP® in patients with methicillin-resistant Staphylococcus aureus infections: A retrospective cohort 万古霉素通用产品与万古霉素CP®在耐甲氧西林金黄色葡萄球菌感染患者中的临床疗效比较:一项回顾性队列研究
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1103
Juliana Castaño-Rendón, Sebastián Sánchez López, Andrés Padierna, M. Palácio, Laura Tobon, María Ossa, C. Muriel, Johana Tello, F. Jaimes
Introduction: Approval of generic drugs requires only bioequivalence studies. Some research suggests that generic vancomycin is not clinically equivalent to the branded drug, and this exposes patients to therapeutic failure and the development of microbial resistance. Aims: Compare the rates of microbiological and clinical failure between generic vancomycin and Vancocin-CP®. Methods: Retrospective cohort analysis of hospitalized adults with culture-proven methicillin-resistant Staphylococcus aureus infection, treated with vancomycin in a tertiary care hospital in Medellín, Colombia. General clinical variables, laboratory findings, severity and mortality scores, and type of vancomycin used were recorded. Logistical regression models, adjusted for potential confounders, were fitted to estimate the effect of vancomycin on clinical and microbiologic outcomes. Results: Of 209 patients, 153 (73.2%) received generic vancomycin and 56 (26.8%) Vancocin-CP®. Systems more commonly affected were skin and soft tissues (28.5%), blood with involvement of catheters (27.6%) and blood without the involvement of catheters (23.3%). There were 62 clinical failures (29.5%) and 41(38%) microbiological failures. The hospital mortality rate was 15% (n = 31); only 7 (3.4%) episodes of adverse drug reactions were documented. No difference was found in the risk of clinical or microbiological failure between Vancocin-CP® and generic products with OR = 2.3 (95% CI = 0.8; 6.3) and 0.89 (95% CI = 0.4; 1.9), respectively.  Conclusion: There were no association between the use of generic vancomycin and the outcomes of clinical or microbiological failure. Sample size is an important limitation for these findings.   Keywords: Vancomycin, bioequivalence, MRSA, clinical equivalence
简介:仿制药的批准只需要生物等效性研究。一些研究表明,仿制万古霉素在临床上并不等同于品牌药,这使患者面临治疗失败和微生物耐药性的发展。目的:比较通用万古霉素和万古霉素- cp®的微生物失败率和临床失败率。方法:回顾性队列分析在哥伦比亚Medellín三级医院接受万古霉素治疗的经培养证实的耐甲氧西林金黄色葡萄球菌感染的住院成人。记录一般临床变量、实验室结果、严重程度和死亡率评分以及使用万古霉素的类型。拟合逻辑回归模型,对潜在混杂因素进行调整,以估计万古霉素对临床和微生物学结果的影响。结果:209例患者中,153例(73.2%)接受通用万古霉素治疗,56例(26.8%)接受万古霉素- cp®治疗。更常受影响的系统是皮肤和软组织(28.5%)、导管受累的血液(27.6%)和未受累的血液(23.3%)。临床失败62例(29.5%),微生物失败41例(38%)。住院死亡率为15% (n = 31);仅记录了7例(3.4%)药物不良反应。万古霉素- cp®与仿制药在临床或微生物失败风险方面无差异,or = 2.3 (95% CI = 0.8;6.3)和0.89 (95% CI = 0.4;分别为1.9)。结论:通用万古霉素的使用与临床或微生物学失败的结果无相关性。样本量是这些发现的一个重要限制。关键词:万古霉素,生物等效性,MRSA,临床等效性
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引用次数: 0
Bilateral infraclavicular brachial plexus nerve blocks in an ambulatory surgery center 门诊手术中心双侧锁骨下臂丛神经阻滞
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1077
B. Rachman, H. Zuercher, Kristina Jones, Nathan Rachman
The approach for upper extremity surgery brachial plexus blocks depends on the specific nature of the surgery. Interscalene and supraclavicular brachial plexus blocks can cause phrenic nerve palsy. Our aim was to explore the safety of bilateral parasagittal infraclavicular brachial plexus blocks (BPBBs) in an outpatient surgery center. Identical BPBBs were performed in two patients with 20 mL of 0.25% bupivacaine. Neither patient developed respiratory or cardiovascular distress. Brachial plexus blocks on multiple locations are infrequently employed for fear of phrenic nerve paresis. However, given both patients’ success, bilateral parasagittal infraclavicular brachial plexus blocks may provide a safe approach. Keywords: Nerve block, brachial plexus blocks, phrenic nerve, anesthesia, pain
上肢手术臂丛阻滞的入路取决于手术的具体性质。斜角肌间和锁骨上臂丛神经阻滞可引起膈神经麻痹。我们的目的是探讨门诊手术中心双侧侧冠状旁锁骨下臂丛阻滞(BPBBs)的安全性。用20 mL 0.25%布比卡因对两例患者进行相同的BPBBs。两名患者均未出现呼吸或心血管窘迫。由于担心膈神经麻痹,臂丛神经阻滞在多个部位很少使用。然而,鉴于两例患者的成功,双侧侧矢状旁锁骨下臂丛阻滞可能是一种安全的入路。关键词:神经阻滞,臂丛神经阻滞,膈神经,麻醉,疼痛
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引用次数: 0
The mental health impact of work from home: a literature review 在家工作对心理健康的影响:文献综述
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1085
A. Sarangi, Dalynn Kim, J. Rafael
The 2020 coronavirus (COVID-19) pandemic has shifted the workplace focus from on-site to remote and has introduced discussions about the positive and negative features of working from home (WFH). Many employees have reported increased control and flexibility regarding one’s schedule with the shift to a remote model. However, there have been increasing concerns regarding the emotional and mental health effects of such a model and the social isolation resulting from staying at home. The lack of professional boundaries, technological limitations, and forced interaction with family members have been considered potentials costs of the convenience of WFH. In this review paper, we discuss the possible benefits and consequences of remote work on various measures of mental health and discuss the implications of future WFH models which may provide workers with greater autonomy and flexibility.
2020年冠状病毒(COVID-19)大流行已将工作场所的重点从现场转移到远程,并引发了关于在家工作(WFH)的积极和消极特征的讨论。许多员工报告说,随着远程模式的转变,他们对自己的日程安排的控制和灵活性增加了。然而,人们越来越关注这种模式对情感和精神健康的影响以及因呆在家里而造成的社会孤立。缺乏专业界限、技术限制以及被迫与家庭成员互动被认为是WFH便利的潜在成本。在这篇综述文章中,我们讨论了远程工作对各种心理健康措施可能带来的好处和后果,并讨论了未来远程工作模式的影响,这些模式可能为工人提供更大的自主权和灵活性。
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引用次数: 1
Machine learning and medicine- a brief introduction 机器学习与医学——简要介绍
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1043
Benjamin Lee, Christopher Peterson
Artificial Intelligence (AI) and Machine Learning (ML) have advanced rapidly in recent years and now have the potential to change medicine. This review serves as an introduction to AI and the potential it has to change medicine. Specific examples of past milestones particularly in the domain of critical care are presented, including algorithms that have been developed that can interpret chest x-rays or predict clinical outcomes such as extubation failure or ICU mortality. Included is a brief general discussion of what AI is, how it is made, and how physicians will be involved with it. Arguments are then presented as to why AI will likely not leave physicians without a job, including expectations vs. reality, AI still requires human supervision, new discoveries bring new challenges, and AI cannot design itself. Far from displacing physicians, AI, if implemented well, stands poised to automate repetitive tasks, make physicians more accurate, and free them up to spend more time with patients.
人工智能(AI)和机器学习(ML)近年来发展迅速,现在有可能改变医学。这篇综述是对人工智能及其改变医学的潜力的介绍。介绍了过去里程碑的具体例子,特别是在重症监护领域,包括已经开发的可以解释胸部x射线或预测临床结果(如拔管失败或ICU死亡率)的算法。书中简要讨论了人工智能是什么,它是如何制造的,以及医生将如何参与其中。然后提出了关于人工智能为什么不会让医生失业的争论,包括期望与现实,人工智能仍然需要人类监督,新发现带来新的挑战,人工智能不能自我设计。人工智能不仅不会取代医生,而且如果实施得当,它将使重复性任务自动化,使医生更准确,并使他们腾出更多时间与患者相处。
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引用次数: 0
Second primary cancer in the brain: a longitudinal case study from childhood into adulthood 第二原发性脑癌:从童年到成年的纵向案例研究
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1065
J. Rahesh, Shazma Khan, A. Siddiqui, R. Jacob
Second cancers occur after the remission of a previous cancer in patients. Due to the increased successful treatment of childhood cancers, these second cancers are more likely to occur for these patients, later in life. Risk factors and causes for these second cancers include predisposing genetic factors, exposure to radiation and chemotherapy from initial cancer treatment, and environmental conditions. The most likely the reason second cancers occur is multifactorial and involves an interaction of both environmental and genetic factors. We present a longitudinal case study following a patient who was treated for an ependymoma at age three and twenty-two years later presenting with symptoms indicative of another cancer, at age 25.
第二种癌症发生在患者先前癌症缓解后。由于儿童癌症的治疗越来越成功,这些患者更有可能在以后的生活中患上第二种癌症。这些第二种癌症的危险因素和原因包括易感遗传因素、最初癌症治疗的放射和化疗暴露以及环境条件。第二种癌症发生的最有可能的原因是多因素的,涉及环境和遗传因素的相互作用。我们提出了一项纵向病例研究,该患者在3岁时因室管膜瘤接受治疗,22年后在25岁时出现另一种癌症的症状。
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引用次数: 0
Cephalexin-induced bradycardia in a young healthy woman 头孢氨苄致年轻健康女性心动过缓
Pub Date : 2022-10-21 DOI: 10.12746/swrccc.v10i45.1095
Mahmoud Abdelnabi, Juthipong Benjanuwattra, Sean Lee, S. E. El Nawaa
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引用次数: 0
期刊
The Southwest Respiratory and Critical Care Chronicles
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