Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.222
Jinsook Lim, Sae-rom Choi, C. Song, Yumi Park, Y. Lim, Jun Nyun Kim, G. Kwon
Background: Nurses play a central role in the process of blood transfusion because they have the closest interac-tions with patients. Providing nurses with the appropriate knowledge and competency through education can help ensure transfusion safety. This study investigated the effectiveness of the first nationwide transfusion-related educa- tion for nurses by analyzing questionnaires for a self-assessment of competency on transfusion-related knowledge before and after the education and general evaluation for the educational program. Methods: The education program was composed of four lectures and was conducted in seven regions in South Korea. One hundred and ninety-two nurses participated, and the questionnaires for 170 nurses were analyzed. Results: The participants consisted of 90 nurses (53.0%) from tertiary hospitals, 23 (13.5%) from general hospitals, and 57 (33.5%) from other hospitals. The majority of the participants (103/170, 60.6%) were from hospitals with ≥ 500 beds, and 69.4% had a work period of ≥ 10 years. The scores for pre-/post-education self-assessment of competency were as follows: blood components, 3.03/3.73; pretransfusion testing, 2.86/3.64; management of transfusion, 3.18/3.84; and transfusion reactions, 3.11/3.78. In all categories, there was a significant increase in the score after the education program. The majority of participants (99.4%) provided a positive response regarding the necessity of a transfusion-related education program. Conclusion: South Korea’s first attempt at transfusion-related education for nurses showed a strong positive effect by improving participants’ transfusion-related competency. Considering the important role of nurses in blood transfusion, the educational program should continue and be expanded in the future. (Korean J 2020;31:222-229)
{"title":"Analysis of the Effects of the Implementation of Transfusion-Related Education for Nurses at Medical Institutions","authors":"Jinsook Lim, Sae-rom Choi, C. Song, Yumi Park, Y. Lim, Jun Nyun Kim, G. Kwon","doi":"10.17945/kjbt.2020.31.3.222","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.222","url":null,"abstract":"Background: Nurses play a central role in the process of blood transfusion because they have the closest interac-tions with patients. Providing nurses with the appropriate knowledge and competency through education can help ensure transfusion safety. This study investigated the effectiveness of the first nationwide transfusion-related educa- tion for nurses by analyzing questionnaires for a self-assessment of competency on transfusion-related knowledge before and after the education and general evaluation for the educational program. Methods: The education program was composed of four lectures and was conducted in seven regions in South Korea. One hundred and ninety-two nurses participated, and the questionnaires for 170 nurses were analyzed. Results: The participants consisted of 90 nurses (53.0%) from tertiary hospitals, 23 (13.5%) from general hospitals, and 57 (33.5%) from other hospitals. The majority of the participants (103/170, 60.6%) were from hospitals with ≥ 500 beds, and 69.4% had a work period of ≥ 10 years. The scores for pre-/post-education self-assessment of competency were as follows: blood components, 3.03/3.73; pretransfusion testing, 2.86/3.64; management of transfusion, 3.18/3.84; and transfusion reactions, 3.11/3.78. In all categories, there was a significant increase in the score after the education program. The majority of participants (99.4%) provided a positive response regarding the necessity of a transfusion-related education program. Conclusion: South Korea’s first attempt at transfusion-related education for nurses showed a strong positive effect by improving participants’ transfusion-related competency. Considering the important role of nurses in blood transfusion, the educational program should continue and be expanded in the future. (Korean J 2020;31:222-229)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131362158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.211
S. Chun, J. Choi, Yung Zoon Jung, J. Shin, Kyeong Eun Jeong, J. Oh, Jun Nyun Kim, Y. Lim
{"title":"Survey on the Preparation Status of Medical Institutions Regarding the Full Revision of the Korean Blood Inventory Monitoring System","authors":"S. Chun, J. Choi, Yung Zoon Jung, J. Shin, Kyeong Eun Jeong, J. Oh, Jun Nyun Kim, Y. Lim","doi":"10.17945/kjbt.2020.31.3.211","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.211","url":null,"abstract":"","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"62 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126269205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.247
S. Song, S. Oh, Shinae Yu, K. R. Jun, Jeong Nyeo Lee
The rhesus (Rh) blood group system is one of the most important systems in transfusion medicine. Rh alloantibodies can cause hemolytic transfusion reactions and difficulties in finding compatible blood. On the other hand, the phenotypic test and pre-transfusion compatibilization for RhCE antigens have not been routinely performed in most clinical laboratories. This study examined the occurrence of Rh alloimmunization, including C, c, E, and e antigens, after Rh incompatible red cell transfusion during a specific period. From November 2016 to December 2017, clinical and laboratory information of transfused patients was collected; this included the transfusion history and Rh phenotypes of the patients and transfused red blood cell (RBC) products. Of 3,623 patients who received red cell transfusion, 99 (2.8%) revealed unexpected antibodies. Among them, 48 patients (48.5%) had alloantibodies to the Rh-system antigen, including the anti-D antibody. Based on the transfusion history and Rh phenotypes of patients and transfused packed RBCs, 11 patients (11.1%) were assumed to develop Rh alloantibodies after discrepant Rh phenotype red cell transfusion. A considerable proportion of unexpected antibodies was caused by the exposure of Rh mismatched red cells. Therefore, extended Rh antigen matching, including the C, c, E, and e, is needed to prevent alloimmunization. (Korean J Blood Transfus 2020;31:247-253)
{"title":"Identification of Rh Alloimmunization after Rh Antigen Incompatible Red Blood Cell Transfusion","authors":"S. Song, S. Oh, Shinae Yu, K. R. Jun, Jeong Nyeo Lee","doi":"10.17945/kjbt.2020.31.3.247","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.247","url":null,"abstract":"The rhesus (Rh) blood group system is one of the most important systems in transfusion medicine. Rh alloantibodies can cause hemolytic transfusion reactions and difficulties in finding compatible blood. On the other hand, the phenotypic test and pre-transfusion compatibilization for RhCE antigens have not been routinely performed in most clinical laboratories. This study examined the occurrence of Rh alloimmunization, including C, c, E, and e antigens, after Rh incompatible red cell transfusion during a specific period. From November 2016 to December 2017, clinical and laboratory information of transfused patients was collected; this included the transfusion history and Rh phenotypes of the patients and transfused red blood cell (RBC) products. Of 3,623 patients who received red cell transfusion, 99 (2.8%) revealed unexpected antibodies. Among them, 48 patients (48.5%) had alloantibodies to the Rh-system antigen, including the anti-D antibody. Based on the transfusion history and Rh phenotypes of patients and transfused packed RBCs, 11 patients (11.1%) were assumed to develop Rh alloantibodies after discrepant Rh phenotype red cell transfusion. A considerable proportion of unexpected antibodies was caused by the exposure of Rh mismatched red cells. Therefore, extended Rh antigen matching, including the C, c, E, and e, is needed to prevent alloimmunization. (Korean J Blood Transfus 2020;31:247-253)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134119192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.239
Seog-Ki Lee, Geon Park
Background: Sequencing and allele separation from exon 2 to exon 7 in the ABO gene can be required to deter-mine the genotype. This study used the seamless cloning technique to clone approximately 7.3 kb containing a portion of exon 2 to exon 7 of the ABO gene. Methods: The previously confirmed DNA sample of the ABO*B.01/O.01 genotype was used for seamless cloning using the Overlap Cloner DNA Cloning Kit (ElpisBio). Cloning was performed three times using the same cloning protocol. The plasmids obtained by cloning were also confirmed by sequencing. Results: Ninety-two colonies (average of 30 colonies per culture plate) were obtained. Of the fifty colonies, 48 colonies were properly amplified. Plasmid sequencing confirmed that 31 heterozygous alleles were well separated in accordance with predictions through the BGMUT database. Conclusion: The data suggest that the seamless cloning technique is a reliable technique that can be used to separate long-range alleles, such as the ABO gene. (Korean 2020;31:239-246)
{"title":"Cloning of ABO PCR Products Including Exon 2 to Exon 7 Using Seamless Cloning Technique","authors":"Seog-Ki Lee, Geon Park","doi":"10.17945/kjbt.2020.31.3.239","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.239","url":null,"abstract":"Background: Sequencing and allele separation from exon 2 to exon 7 in the ABO gene can be required to deter-mine the genotype. This study used the seamless cloning technique to clone approximately 7.3 kb containing a portion of exon 2 to exon 7 of the ABO gene. Methods: The previously confirmed DNA sample of the ABO*B.01/O.01 genotype was used for seamless cloning using the Overlap Cloner DNA Cloning Kit (ElpisBio). Cloning was performed three times using the same cloning protocol. The plasmids obtained by cloning were also confirmed by sequencing. Results: Ninety-two colonies (average of 30 colonies per culture plate) were obtained. Of the fifty colonies, 48 colonies were properly amplified. Plasmid sequencing confirmed that 31 heterozygous alleles were well separated in accordance with predictions through the BGMUT database. Conclusion: The data suggest that the seamless cloning technique is a reliable technique that can be used to separate long-range alleles, such as the ABO gene. (Korean 2020;31:239-246)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130116996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.230
Dae Ho Ko, J. Kang, Jungwon Kang, M. Youn
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CopyrightC2020 The Korean Society of Blood Transfusion 뎅기열 유행 지역 여행자를 근거로 산출한 뎅기바이러스 오염 혈액제제의 발생 위험도 분석
this is an open access article distributed under the terms of the creative creativecommons attribution non - commercial license (http: / /听说过。org / licenses / by - nc / 4.0) which permits unrestrictednon-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited。CopyrightC2020 The Korean Society of Blood Transfusion根据登革热流行地区旅行者计算出的登革热病毒污染血液制剂发生危险度分析
{"title":"Risk Assessment of the Occurrence of Blood Products Infected with Dengue Virus Based on Travelers to the Areas of Dengue Outbreak","authors":"Dae Ho Ko, J. Kang, Jungwon Kang, M. Youn","doi":"10.17945/kjbt.2020.31.3.230","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.230","url":null,"abstract":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CopyrightC2020 The Korean Society of Blood Transfusion 뎅기열 유행 지역 여행자를 근거로 산출한 뎅기바이러스 오염 혈액제제의 발생 위험도 분석","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131797869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.201
Jaehyun Kim
Blood components can be prepared from whole blood either using the platelet-rich plasma (PRP) method or buffy-coat (BC) method. The use of these two whole blood processing methods varies greatly between countries. The PRP method is used in Korea, while the BC method is used in Europe. On the other hand, the BC method with the automated device is being used more widely in many countries. Only a few countries still use the PRP method for whole blood processing, with Korea remaining among them. The choice of the use of a specific whole blood processing method should consider all aspects of safety, quality, and efficiency as well as process costs. This review summarizes the existing information on PRP and BC methods for whole blood processing, particularly comparing both methods. (Korean J Blood Transfus 2020;31:201-210)
{"title":"Whole Blood Processing Using the Buffy-Coat Method","authors":"Jaehyun Kim","doi":"10.17945/kjbt.2020.31.3.201","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.201","url":null,"abstract":"Blood components can be prepared from whole blood either using the platelet-rich plasma (PRP) method or buffy-coat (BC) method. The use of these two whole blood processing methods varies greatly between countries. The PRP method is used in Korea, while the BC method is used in Europe. On the other hand, the BC method with the automated device is being used more widely in many countries. Only a few countries still use the PRP method for whole blood processing, with Korea remaining among them. The choice of the use of a specific whole blood processing method should consider all aspects of safety, quality, and efficiency as well as process costs. This review summarizes the existing information on PRP and BC methods for whole blood processing, particularly comparing both methods. (Korean J Blood Transfus 2020;31:201-210)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125514713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.260
Jaehyun Kim
Until recently, there was no formal regulation to cover the preparation of blood and blood components for transfusion in Korea; it was perceived as part of medical practice rather than the preparation of a biological therapeutic product. On the other hand, in accordance with the revision of the Korean Pharmaceutical Affairs Act, blood and blood components for transfusion have been under formal regulations enforced by the Ministry of Food and Drug Safety (MFDS) since January 2019. The regulation requires that blood establishments be licensed and subjected to regular inspection for good manufacturing practices (GMP) compliance. The preparation of blood and blood components is different from plasma-derived medicinal products (PDMPs) manufacturing and pharmaceutical medicines in general. Therefore, to accelerate the implementation of a regulatory system and reach an acceptable compliance status, blood establishments should be engaged to address the specific attributes of blood and blood components for transfusion. (Korean J Blood Transfus 2020;31:260-264)
{"title":"Good Manufacturing Practices (GMP) for Blood and Blood Components, What Do You Know and How to Prepare?","authors":"Jaehyun Kim","doi":"10.17945/kjbt.2020.31.3.260","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.260","url":null,"abstract":"Until recently, there was no formal regulation to cover the preparation of blood and blood components for transfusion in Korea; it was perceived as part of medical practice rather than the preparation of a biological therapeutic product. On the other hand, in accordance with the revision of the Korean Pharmaceutical Affairs Act, blood and blood components for transfusion have been under formal regulations enforced by the Ministry of Food and Drug Safety (MFDS) since January 2019. The regulation requires that blood establishments be licensed and subjected to regular inspection for good manufacturing practices (GMP) compliance. The preparation of blood and blood components is different from plasma-derived medicinal products (PDMPs) manufacturing and pharmaceutical medicines in general. Therefore, to accelerate the implementation of a regulatory system and reach an acceptable compliance status, blood establishments should be engaged to address the specific attributes of blood and blood components for transfusion. (Korean J Blood Transfus 2020;31:260-264)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130685389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.193
Kyung-Hee Kim, Jaehyun Kim, D. Cho
The Korean Journal of Blood Transfusion (KJBT) is a representative journal in the field of transfusion medicine and has contributed to the development of the national blood business and clinical research. The KJBT was selected as a candidate journal registered in the Korea Citation Index (KCI) in 2009 and was selected as a KCI-registered journal in 2016. The KJBT has published 796 articles, including 601 original articles and 144 case reports from the first issue to volume 31, number 2. The KJBT has continuously introduced new tools for improving journals but was assessed as having a high self-citation rate because of the characteristics of the journal. Nevertheless, it is necessary to increase the number of papers to improve the value of the KJBT. To accomplish this, continuous efforts of the editorial committee will be needed to provide better services to authors and readers and to promote journals. (Korean J Blood Transfus 2020;31:193-200)
《韩国输血杂志》(Korean Journal of Blood Transfusion，简称KJBT)是输血医学领域的代表性期刊，对国家血液事业和临床研究的发展做出了贡献。kbt于2009年被选定为韩国引文索引(KCI)候选期刊，并于2016年被选定为KCI注册期刊。从第一期到第31卷第2期，KJBT共发表了796篇文章，其中包括601篇原创文章和144篇病例报告。虽然KJBT不断推出新的期刊改进工具，但由于期刊的特点，被评价为自引率较高。然而，有必要增加论文的数量，以提高KJBT的价值。为了实现这一目标，编辑委员会将继续努力为作者和读者提供更好的服务，并促进期刊的发展。(韩国输血杂志2020;31:193-200)
{"title":"Current Status of Our Journal, The Korean Journal of Blood Transfusion","authors":"Kyung-Hee Kim, Jaehyun Kim, D. Cho","doi":"10.17945/kjbt.2020.31.3.193","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.193","url":null,"abstract":"The Korean Journal of Blood Transfusion (KJBT) is a representative journal in the field of transfusion medicine and has contributed to the development of the national blood business and clinical research. The KJBT was selected as a candidate journal registered in the Korea Citation Index (KCI) in 2009 and was selected as a KCI-registered journal in 2016. The KJBT has published 796 articles, including 601 original articles and 144 case reports from the first issue to volume 31, number 2. The KJBT has continuously introduced new tools for improving journals but was assessed as having a high self-citation rate because of the characteristics of the journal. Nevertheless, it is necessary to increase the number of papers to improve the value of the KJBT. To accomplish this, continuous efforts of the editorial committee will be needed to provide better services to authors and readers and to promote journals. (Korean J Blood Transfus 2020;31:193-200)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123156306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.17945/kjbt.2020.31.3.254
HongBi Yu, Yoo Na Chung, Tae Yeul Kim, Eun-Mee Suh, Kwang-Mo Choi, D. Cho
Cis-AB and B(A) alleles encode an ABO enzyme with dual A and B glycosyltransferase activity. Although globally rare, the cis -AB phenotype is found relatively often in Korean, Japanese, and Chinese populations. Cases of the B(A) allele have been reported mostly in the Chinese population. Forward typing performed in a Cambodian woman with an ABO discrepancy demonstrated a strong reaction with anti-A and anti-B reagents, while there was no reaction with lectin anti-A 1 . The anti-A 1 antibody was detected in reverse typing. Through ABO gene sequence analyses of exons 6 and 7, one of the alleles was identified as ABO*B.01 . In contrast, the other allele harboring a c.803G ＞ C substitution was either ABO*cisAB.05 or ABO*BA.06 allele. The ABO*cisAB.05 and ABO*BA.06 alleles remain indistinguishable despite routine serological testing and ABO genotyping. To the best of the author’s knowledge, this is the first case report of these variants discovered in a Cambodian individual residing in Korea. (Korean J Blood Transfus 2020;31:254-259)
{"title":"Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A2B Phenotype","authors":"HongBi Yu, Yoo Na Chung, Tae Yeul Kim, Eun-Mee Suh, Kwang-Mo Choi, D. Cho","doi":"10.17945/kjbt.2020.31.3.254","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.3.254","url":null,"abstract":"Cis-AB and B(A) alleles encode an ABO enzyme with dual A and B glycosyltransferase activity. Although globally rare, the cis -AB phenotype is found relatively often in Korean, Japanese, and Chinese populations. Cases of the B(A) allele have been reported mostly in the Chinese population. Forward typing performed in a Cambodian woman with an ABO discrepancy demonstrated a strong reaction with anti-A and anti-B reagents, while there was no reaction with lectin anti-A 1 . The anti-A 1 antibody was detected in reverse typing. Through ABO gene sequence analyses of exons 6 and 7, one of the alleles was identified as ABO*B.01 . In contrast, the other allele harboring a c.803G ＞ C substitution was either ABO*cisAB.05 or ABO*BA.06 allele. The ABO*cisAB.05 and ABO*BA.06 alleles remain indistinguishable despite routine serological testing and ABO genotyping. To the best of the author’s knowledge, this is the first case report of these variants discovered in a Cambodian individual residing in Korea. (Korean J Blood Transfus 2020;31:254-259)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131589261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-31DOI: 10.17945/kjbt.2020.31.2.109
E. Kang, C. Lim, K. Han, Dae‐Won Kim
Eun-Suk Kang, M.D., Chae Seung Lim, M.D., Kyou Sup Han, M.D., Dae-Won Kim, M.D. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Department of Laboratory Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul; Seegene Medical Foundation, Seoul; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul; Department of Laboratory Medicine, Korea University Anam Hospital, Korean University School of Medicine, Seoul, Korea
{"title":"Hematopoietic Stem Cell Registry Report: 2018","authors":"E. Kang, C. Lim, K. Han, Dae‐Won Kim","doi":"10.17945/kjbt.2020.31.2.109","DOIUrl":"https://doi.org/10.17945/kjbt.2020.31.2.109","url":null,"abstract":"Eun-Suk Kang, M.D., Chae Seung Lim, M.D., Kyou Sup Han, M.D., Dae-Won Kim, M.D. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Department of Laboratory Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul; Seegene Medical Foundation, Seoul; Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul; Department of Laboratory Medicine, Korea University Anam Hospital, Korean University School of Medicine, Seoul, Korea","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128441729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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