V. Tsiperson, O. Goldshmidt, N. Ilan, G. Shoshany, I. Vlodavsky, E. Veitsman, Y. Baruch
{"title":"Heparanase Enhances Early Hepatocyte Inclusion in the Recipient Liver after Transplantation in Partially Hepatectomized Rats","authors":"V. Tsiperson, O. Goldshmidt, N. Ilan, G. Shoshany, I. Vlodavsky, E. Veitsman, Y. Baruch","doi":"10.1089/ten.2006.0435","DOIUrl":"https://doi.org/10.1089/ten.2006.0435","url":null,"abstract":"","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"1 1","pages":"110306233438005"},"PeriodicalIF":0.0,"publicationDate":"2007-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60528430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Morikuni Tobita, A. Uysal, R. Ogawa, H. Hyakusoku, H. Mizuno
The invention is a microcomponent sheet architecture wherein macroscale unit processes are performed by microscale components. The sheet architecture may be a single laminate with a plurality of separate microcomponent sections or the sheet architecture may be a plurality of laminates with one or more microcomponent sections on each laminate. Each microcomponent or plurality of like microcomponents perform at least one chemical process unit operation. A first laminate having a plurality of like first microcomponents is combined with at least a second laminate having a plurality of like second microcomponents thereby combining at least two unit operations to achieve a system operation.
{"title":"Periodontal Tissue Regeneration with Adipose-Derived Stem Cells","authors":"Morikuni Tobita, A. Uysal, R. Ogawa, H. Hyakusoku, H. Mizuno","doi":"10.1089/ten.2007.0048","DOIUrl":"https://doi.org/10.1089/ten.2007.0048","url":null,"abstract":"The invention is a microcomponent sheet architecture wherein macroscale unit processes are performed by microscale components. The sheet architecture may be a single laminate with a plurality of separate microcomponent sections or the sheet architecture may be a plurality of laminates with one or more microcomponent sections on each laminate. Each microcomponent or plurality of like microcomponents perform at least one chemical process unit operation. A first laminate having a plurality of like first microcomponents is combined with at least a second laminate having a plurality of like second microcomponents thereby combining at least two unit operations to achieve a system operation.","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"1 1","pages":"110306233438005"},"PeriodicalIF":0.0,"publicationDate":"2007-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60529156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differential Effects of Natriuretic Peptide Stimulation on Tissue-Engineered Cartilage","authors":"S. Waldman, Y. Usmani, M. Tse, S. Pang","doi":"10.1089/ten.2007.0035","DOIUrl":"https://doi.org/10.1089/ten.2007.0035","url":null,"abstract":"","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"6 1","pages":"110306233438005"},"PeriodicalIF":0.0,"publicationDate":"2007-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60529057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James R. McMillan, M. Akiyama, Masaru Tanaka, S. Yamamoto, Riichiro Abe, K. Kodama, Masatsugu Shimomura, M. Shimizu
We have previously demonstrated that porous poly-(epsiloncalprolactone) films with regularly spaced, controlled pore sizes provide adhesion and support for cultured dermal fibroblasts. We have determined the effects of applying various sized porous films (n¼3 for each treatment) on 4mm punch biopsy wounded mice to assess wounding response. Films with pores ranging in size from 3–20 microns, elicited a mild lymphocytic and foreign body perifollicular immune response, regardless of pore size but this treatment failed to significantly shorten wound healing time or increase the rate of wound closure. By 21 days after wounding the grafted porous films had become fully incorporated into or completely biodegraded in the wounded tissue. Finally, we assessed the proof of principle that live cultured fibroblasts can be delivered using porous films and sustained in model SCID mouse wounds. Human fibroblasts (30,000 cells) were subconfluently cultured on 5 micron porous films. These cell/film combinations were then transplanted onto wounded mice but failed to significantly affect wound healing. However, these transplanted fibroblast cells were readily detected using anti-human HLA antibodies in wounded SCID mice skin 21 days after treatment, when the wounds had completely healed. Taken together, these data demonstrate for the first time the feasibility of using porous films to deliver living human cells into skin wounds as part of our aim to use cell therapy to improve the wound healing response.
{"title":"Characterisation of human fetal progenitor populations and response to osteogenic growth factors: a model system for mesenchymal lineage differentiation","authors":"James R. McMillan, M. Akiyama, Masaru Tanaka, S. Yamamoto, Riichiro Abe, K. Kodama, Masatsugu Shimomura, M. Shimizu","doi":"10.1089/ten.2007.1501","DOIUrl":"https://doi.org/10.1089/ten.2007.1501","url":null,"abstract":"We have previously demonstrated that porous poly-(epsiloncalprolactone) films with regularly spaced, controlled pore sizes provide adhesion and support for cultured dermal fibroblasts. We have determined the effects of applying various sized porous films (n¼3 for each treatment) on 4mm punch biopsy wounded mice to assess wounding response. Films with pores ranging in size from 3–20 microns, elicited a mild lymphocytic and foreign body perifollicular immune response, regardless of pore size but this treatment failed to significantly shorten wound healing time or increase the rate of wound closure. By 21 days after wounding the grafted porous films had become fully incorporated into or completely biodegraded in the wounded tissue. Finally, we assessed the proof of principle that live cultured fibroblasts can be delivered using porous films and sustained in model SCID mouse wounds. Human fibroblasts (30,000 cells) were subconfluently cultured on 5 micron porous films. These cell/film combinations were then transplanted onto wounded mice but failed to significantly affect wound healing. However, these transplanted fibroblast cells were readily detected using anti-human HLA antibodies in wounded SCID mice skin 21 days after treatment, when the wounds had completely healed. Taken together, these data demonstrate for the first time the feasibility of using porous films to deliver living human cells into skin wounds as part of our aim to use cell therapy to improve the wound healing response.","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/ten.2007.1501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60529306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-12-18DOI: 10.1089/TEN.2006.12.3567
A. Goldstein
{"title":"Basic Transport Phenomena in Biomedical Engineering, Second Edition: Basic Transport Phenomena in Biomedical Engineering, Second Edition","authors":"A. Goldstein","doi":"10.1089/TEN.2006.12.3567","DOIUrl":"https://doi.org/10.1089/TEN.2006.12.3567","url":null,"abstract":"","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/TEN.2006.12.3567","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60528817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-09-28DOI: 10.1089/TEN.2006.12.FT-218
H. Hosseinkhani, T. Azzam, Hisatoshi Kobayashi, Y. Hiraoka, H. Shimokawa, A. Domb, Y. Tabata
{"title":"Bone Tissue Engineering Through a Combination of 3-Dimensional Tissue Engineered Scaffold and Transfected Mesenchymal Stem Cells","authors":"H. Hosseinkhani, T. Azzam, Hisatoshi Kobayashi, Y. Hiraoka, H. Shimokawa, A. Domb, Y. Tabata","doi":"10.1089/TEN.2006.12.FT-218","DOIUrl":"https://doi.org/10.1089/TEN.2006.12.FT-218","url":null,"abstract":"","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"1 1","pages":"060928122958004"},"PeriodicalIF":0.0,"publicationDate":"2006-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60528910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-07-17DOI: 10.1089/TEN.2006.12.1379
A. Mikos, Peter C. Johnson
{"title":"Editorial Redefining Tissue Engineering . . . and Our New Rapid Publication Policy","authors":"A. Mikos, Peter C. Johnson","doi":"10.1089/TEN.2006.12.1379","DOIUrl":"https://doi.org/10.1089/TEN.2006.12.1379","url":null,"abstract":"","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"12 1","pages":"1379-1380"},"PeriodicalIF":0.0,"publicationDate":"2006-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/TEN.2006.12.1379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60528807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paper investifates changes in cellular adhesion induced by electrostatically spun tissue engineering scaffolds.
本文研究了静电纺组织工程支架对细胞黏附的影响。
{"title":"Investigating changes in cellular adhesion induced by electrostatically spun tissue engineering scaffolds","authors":"K. Andrews, R. Black, J. Hunt","doi":"10.1089/TEN.2006.12.981","DOIUrl":"https://doi.org/10.1089/TEN.2006.12.981","url":null,"abstract":"Paper investifates changes in cellular adhesion induced by electrostatically spun tissue engineering scaffolds.","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/TEN.2006.12.981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60528886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-11-22DOI: 10.1089/TEN.2004.10.1346
Terry W. Hudson, Stephen Y Liu, C. Schmidt
The long-term goal of our research is to engineer an acellular nerve graft for clinical nerve repair and for use as a model system with which to study nerve-extracellular matrix interactions during nerve regeneration. To develop this model acellular nerve graft we (1) examined the effects of detergents on peripheral nerve tissue, and (2) used that knowledge to create a nerve graft devoid of cells with a well-preserved extracellular matrix. Using histochemistry and Western analysis, the impact of each detergent on cellular and extracellular tissue components was determined. An optimized protocol was created with the detergents Triton X-200, sulfobetaine-16, and sulfobetaine-10. This study represents the most comprehensive examination to date of the effects of detergents on peripheral nerve tissue morphology and protein composition. Also presented is an improved chemical decellularization protocol that preserves the internal structure of native nerve more than the predominant current protocol.
{"title":"Engineering an improved acellular nerve graft via optimized chemical processing.","authors":"Terry W. Hudson, Stephen Y Liu, C. Schmidt","doi":"10.1089/TEN.2004.10.1346","DOIUrl":"https://doi.org/10.1089/TEN.2004.10.1346","url":null,"abstract":"The long-term goal of our research is to engineer an acellular nerve graft for clinical nerve repair and for use as a model system with which to study nerve-extracellular matrix interactions during nerve regeneration. To develop this model acellular nerve graft we (1) examined the effects of detergents on peripheral nerve tissue, and (2) used that knowledge to create a nerve graft devoid of cells with a well-preserved extracellular matrix. Using histochemistry and Western analysis, the impact of each detergent on cellular and extracellular tissue components was determined. An optimized protocol was created with the detergents Triton X-200, sulfobetaine-16, and sulfobetaine-10. This study represents the most comprehensive examination to date of the effects of detergents on peripheral nerve tissue morphology and protein composition. Also presented is an improved chemical decellularization protocol that preserves the internal structure of native nerve more than the predominant current protocol.","PeriodicalId":23133,"journal":{"name":"Tissue Engineering Part A","volume":"10 1","pages":"1346-58"},"PeriodicalIF":0.0,"publicationDate":"2004-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/TEN.2004.10.1346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60528740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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