{"title":"Systematic review on the adverse reactions of oral administration of Indigo Naturalis and its preparations","authors":"Xueyi Deng, Ruirui Lan, Qianwen Xie, Jingmin Xiao, Jiaqi Lai, Jing Chen, Yihan He, Shaonan Liu, Lihong Yang, Xin-feng Guo","doi":"10.53388/mhm2021b0117001","DOIUrl":"https://doi.org/10.53388/mhm2021b0117001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75391009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/mhm2021a0401001
Ji Xu, Hongyong Deng
{"title":"JSON-ASR: A lightweight data storage and exchange format for automatic systematic reviews of TCM","authors":"Ji Xu, Hongyong Deng","doi":"10.53388/mhm2021a0401001","DOIUrl":"https://doi.org/10.53388/mhm2021a0401001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88291193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/mhm2021a1008002
Jinghan Wang, Zhen Hua, Chao Li, Yun-Li Li
{"title":"The clinical efficacy of traditional Chinese medicine in the auxiliary treatment of grade 1 hypertension: A systematic review and meta-analysis","authors":"Jinghan Wang, Zhen Hua, Chao Li, Yun-Li Li","doi":"10.53388/mhm2021a1008002","DOIUrl":"https://doi.org/10.53388/mhm2021a1008002","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87918408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/mhm2021m0305001
Ning Liu, Tao He, Chuanxin Liu, Jianmei Huang
{"title":"Research of the clinical efficacy of Qiming Granule in treatment of diabetic nephropathy by meta-analysis","authors":"Ning Liu, Tao He, Chuanxin Liu, Jianmei Huang","doi":"10.53388/mhm2021m0305001","DOIUrl":"https://doi.org/10.53388/mhm2021m0305001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76936105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/mhm2021b0420001
Jie Chen, Xiaohong Wei, Qian Zhang, Huan Xia, Guiyang Xia, Yuzhuo Wu, Sheng Lin, H. Shang
{"title":"Progress of ubiquitin-proteasome system in the pathophysiology of heart failure and the intervention of traditional Chinese medicine","authors":"Jie Chen, Xiaohong Wei, Qian Zhang, Huan Xia, Guiyang Xia, Yuzhuo Wu, Sheng Lin, H. Shang","doi":"10.53388/mhm2021b0420001","DOIUrl":"https://doi.org/10.53388/mhm2021b0420001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"44 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75681142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.53388/mhm2020c1106001
Yanyu Zhang, X. Cui, Jie Xu
{"title":"The therapeutic efficiency of ursodeoxycholic acid on Gilbert syndrome complicated by aplastic anemia: a series of case reports","authors":"Yanyu Zhang, X. Cui, Jie Xu","doi":"10.53388/mhm2020c1106001","DOIUrl":"https://doi.org/10.53388/mhm2020c1106001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90578317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Rong, Lei Wang, Lingling Yu, Junying Wang, Yanzhen Ma, Liting Wang, Suxia Li, Chun-lin Tang, Liming Lu, Liang Li, Jiazi Dong, J. Fang, Liwei Hou, Zongshi Qin, Xiao-lan Su, Yufeng Zhao, Zhangjin Zhang
BACKGROUND The global spread of the 2019 coronavirus diseases (COVID-19) has caused emotional distress. However, whether auricular vagus nerve acupressure (AVNA) is effective in improving emotional distress under the COVID-19 has not been well-documented. OBJECTIVE To confirm whether AVNA is effective in improving emotional distress under the COVID-19 pandemic. METHODS A smartphone-based online, randomized, controlled trial was designed in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China, from 26 February 2020 to 28 April 2020. Participants were randomly assigned to three times of AVNA (n = 191) or usual care (UC, n = 215) for 14 days. The primary outcome was the response rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS) score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 days. RESULTS The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%, P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reduction in score of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effect size of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep quality being remarkably higher than those with UC at endpoint. CONCLUSIONS AVNA can be recommended for patients with emotional distress under the current COVID-19 pandemic and other emergent events. CLINICALTRIAL www.chictr.org.cn Identifier: ChiCTR2000030078.
背景2019冠状病毒病(COVID-19)的全球传播引发了情绪困扰。然而，耳穴迷走神经指压(AVNA)是否有效改善COVID-19下的情绪困扰尚未得到充分的证明。目的探讨AVNA是否能有效改善新冠肺炎大流行背景下的情绪困扰。方法于2020年2月26日至2020年4月28日在中国武汉、北京、沈阳和广州4个研究地点设计一项基于智能手机的在线、随机、对照试验。参与者被随机分配到3次AVNA (n = 191)或常规护理(n = 215)，持续14天。主要终点是应答率，即医院焦虑和抑郁量表(HADS)评分较基线降低≥50%的参与者比例。评估分别在基线、第3天和第14天进行。结果AVNA组治疗3 d (35.6% vs. 24.9%， P = 0.02)和14 d (70.7% vs. 60.6%， P = 0.02)的有效率明显高于UC组。AVNA组在两个测点的HADS评分和3 d的BAI评分均有显著性降低(P≤0.03)，平均效应量分别为0.217和0.195。AVNA患者入睡时间更短，睡眠质量评分明显高于UC患者。结论在当前COVID-19大流行及其他突发事件的情况下，可以推荐AVNA用于情绪困扰患者。临床试验www.chictr.org.cn标识符:ChiCTR2000030078。
{"title":"Auricular Vagus Nerve Acupressure for Patients with Emotional Distress under the COVID-19 Pandemic: A Smartphone-based, Randomized，Controlled Trial (Preprint)","authors":"P. Rong, Lei Wang, Lingling Yu, Junying Wang, Yanzhen Ma, Liting Wang, Suxia Li, Chun-lin Tang, Liming Lu, Liang Li, Jiazi Dong, J. Fang, Liwei Hou, Zongshi Qin, Xiao-lan Su, Yufeng Zhao, Zhangjin Zhang","doi":"10.2196/preprints.25001","DOIUrl":"https://doi.org/10.2196/preprints.25001","url":null,"abstract":"\u0000 BACKGROUND\u0000 The global spread of the 2019 coronavirus diseases (COVID-19) has caused emotional distress. However, whether auricular vagus nerve acupressure (AVNA) is effective in improving emotional distress under the COVID-19 has not been well-documented.\u0000 \u0000 \u0000 OBJECTIVE\u0000 To confirm whether AVNA is effective in improving emotional distress under the COVID-19 pandemic.\u0000 \u0000 \u0000 METHODS\u0000 A smartphone-based online, randomized, controlled trial was designed in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China, from 26 February 2020 to 28 April 2020. Participants were randomly assigned to three times of AVNA (n = 191) or usual care (UC, n = 215) for 14 days. The primary outcome was the response rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS) score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 days.\u0000 \u0000 \u0000 RESULTS\u0000 The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%, P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reduction in score of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effect size of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep quality being remarkably higher than those with UC at endpoint.\u0000 \u0000 \u0000 CONCLUSIONS\u0000 AVNA can be recommended for patients with emotional distress under the current COVID-19 pandemic and other emergent events.\u0000 \u0000 \u0000 CLINICALTRIAL\u0000 www.chictr.org.cn Identifier: ChiCTR2000030078.\u0000","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85728953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-12DOI: 10.21203/rs.3.rs-34640/v1
Chuying Huo, Huayi Yang, W. Ning, Lin-zhong Yu, Chunlin Fan, Jingyu Quan, L. Deng, Zhi-Ling Yu, Junshan Liu, Huihui Cao
Background: Chronic renal failure (CRF) is a worldwide public health burden. Niaoduqing granules (NDQ) is widely used for CRF treatment in China. However, the underlying mechanism of NDQ is not fully studied. This study is aimed to investigate whether NDQ ameliorate CRF by inhibiting TGF-β1-induced EMT in human renal tubular epithelial HK-2 cells.Methods: MTT assay and colony formation assay were used to investigate the cytotoxicity of NDQ in HK-2 cells. Morphological changes of HK-2 cells after TGF-β1 or/and NDQ treatment were observed under a microscope. Wound-healing, migration and invasion assays were performed to determine the cell movement, migratory and invasive abilities, respectively. Western blot analysis was carried out to examine the protein levels of TGF-β type I receptor (TβRI) and EMT-associated factors. Fluorescence confocal microscopy was applied to observe the organization of F-actin.Results: NDQ suppressed TβRI expression dose-dependently. NDQ inhibited TGF-β1-stimulated EMT in HK-2 cells, supported by the evidences that NDQ prevented morphology change, attenuated cell migration and invasion, downregulated EMT factors and reorganized F-actin distribution in TGF-β1-stimulated HK-2 cells.Conclusions: NDQ attenuates chronic renal failure which may be associated with inhibition of TβRI expression and EMT process.
{"title":"Niaoduqing Granules Inhibits TGF-β1-induced Epithelial-Mesenchymal Transition in Human Renal Tubular Epithelial HK-2 Cells","authors":"Chuying Huo, Huayi Yang, W. Ning, Lin-zhong Yu, Chunlin Fan, Jingyu Quan, L. Deng, Zhi-Ling Yu, Junshan Liu, Huihui Cao","doi":"10.21203/rs.3.rs-34640/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-34640/v1","url":null,"abstract":"\u0000 Background: Chronic renal failure (CRF) is a worldwide public health burden. Niaoduqing granules (NDQ) is widely used for CRF treatment in China. However, the underlying mechanism of NDQ is not fully studied. This study is aimed to investigate whether NDQ ameliorate CRF by inhibiting TGF-β1-induced EMT in human renal tubular epithelial HK-2 cells.Methods: MTT assay and colony formation assay were used to investigate the cytotoxicity of NDQ in HK-2 cells. Morphological changes of HK-2 cells after TGF-β1 or/and NDQ treatment were observed under a microscope. Wound-healing, migration and invasion assays were performed to determine the cell movement, migratory and invasive abilities, respectively. Western blot analysis was carried out to examine the protein levels of TGF-β type I receptor (TβRI) and EMT-associated factors. Fluorescence confocal microscopy was applied to observe the organization of F-actin.Results: NDQ suppressed TβRI expression dose-dependently. NDQ inhibited TGF-β1-stimulated EMT in HK-2 cells, supported by the evidences that NDQ prevented morphology change, attenuated cell migration and invasion, downregulated EMT factors and reorganized F-actin distribution in TGF-β1-stimulated HK-2 cells.Conclusions: NDQ attenuates chronic renal failure which may be associated with inhibition of TβRI expression and EMT process.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77748159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of theophylline/chitosan/β-cyclodextrin microspheres for oral drug delivery on an asthmatic rat model","authors":"Saisai Wang, Haijing Zhang, Xiaoming Cui, Liping Zhao, Mingxia Jiang, Zhilu Xu, Dong-zhen Mu, Weifen Zhang","doi":"10.12032/TMRMHM202003071","DOIUrl":"https://doi.org/10.12032/TMRMHM202003071","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75477742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-01DOI: 10.12032/TMRMHM202003076
Lichao Sun, Guihua Tian, H. Shang
{"title":"The roles of traditional Chinese herbal medications in regulating mitochondrial activity to reverse cancer","authors":"Lichao Sun, Guihua Tian, H. Shang","doi":"10.12032/TMRMHM202003076","DOIUrl":"https://doi.org/10.12032/TMRMHM202003076","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88617943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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