M. Eslami, B. Jameie, Raheleh Mollajani, Jinous Manouchehri
: Neurodegenerative dysfunction is an improvement defeat of construction and utility of neurons. Parkinson, Alzheimer, central stroke, anxiety, and depression are examples of such disorders. To improve the quality of life in people with neurodegenerative diseases, Yoga therapy is operative. Yoga has valuable properties through direct influence on the sympathetic and parasympathetic activity in the autonomic nervous system. It decreases expressively neurotransmitters that are involved in these illnesses. Mind’s relaxation and diaphragmatic respiration (MRDR) on basis of scientific Yoga progresses social interactions, quality of life, and helps individuals approach life with new positivity and ability. The aim of this study was to improve the significant role of NRDR techniques as complementary medicine in prevention and control of neurodegenerative disorders.
{"title":"Mind’s Relaxation and Diaphragmatic Respiration on the Basis of Scientific Yoga and its Application in Neurodegenerative Diseases","authors":"M. Eslami, B. Jameie, Raheleh Mollajani, Jinous Manouchehri","doi":"10.5812/THRITA.64633","DOIUrl":"https://doi.org/10.5812/THRITA.64633","url":null,"abstract":": Neurodegenerative dysfunction is an improvement defeat of construction and utility of neurons. Parkinson, Alzheimer, central stroke, anxiety, and depression are examples of such disorders. To improve the quality of life in people with neurodegenerative diseases, Yoga therapy is operative. Yoga has valuable properties through direct influence on the sympathetic and parasympathetic activity in the autonomic nervous system. It decreases expressively neurotransmitters that are involved in these illnesses. Mind’s relaxation and diaphragmatic respiration (MRDR) on basis of scientific Yoga progresses social interactions, quality of life, and helps individuals approach life with new positivity and ability. The aim of this study was to improve the significant role of NRDR techniques as complementary medicine in prevention and control of neurodegenerative disorders.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90083399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryam Doshmanziari, A. Sarveazad, F. Moradi, Marjan Shariatpanahi, E. Doshmanziari, S. Simorgh, M. Eftekharzadeh
Background: Alzheimer's disease (AD) is a progressive neuropsychiatric disorder that gradually impairs memory and behavioral functions. Amyloid beta (Aβ) is considered as the most toxic substance in the brain of AD patients. Objectives: The present study was designed to evaluate Aβ deposits by Immuno- and Thioflavin S-costaining in the hippocampus of a rat model of AD after intravenous injection of human adipose-derived stem cells (hADSCs). Methods: Thirty-two male rats were included in the four groups of control, sham, AD and hADSCs. The hADSCs characterization was confirmed by the flow cytometry technique. Immuno- and Thioflavin S-costaining was utilized for detecting Aβ plaques in the hippocampus of a rat model of AD following injection of hADSCs. Results: Statistical analysis revealed that Aβ plaques increased significantly in the AD group compared to the control and sham groups. The administration of hADSCs significantly decreased immunoreactivity and Thio-S-positive plaques in the AD group. We also found that the plaques detected by anti-Aβ antibody (immunohistochemical staining) were significantly more than those distinguished by Thioflavin-S in all the groups. Conclusions: Results showed that hADSCs played an effective role in decreasing amyloids aggregation following migration to the hippocampus of the rat model of AD.
{"title":"Evaluation of Aβ Deposits in the Hippocampus of a Rat Model of Alzheimer’s Disease After Intravenous Injection of Human Adipose Derived Stem Cells by Immuno- and Thioflavin S-Costaining","authors":"Maryam Doshmanziari, A. Sarveazad, F. Moradi, Marjan Shariatpanahi, E. Doshmanziari, S. Simorgh, M. Eftekharzadeh","doi":"10.5812/THRITA.88367","DOIUrl":"https://doi.org/10.5812/THRITA.88367","url":null,"abstract":"Background: Alzheimer's disease (AD) is a progressive neuropsychiatric disorder that gradually impairs memory and behavioral functions. Amyloid beta (Aβ) is considered as the most toxic substance in the brain of AD patients. Objectives: The present study was designed to evaluate Aβ deposits by Immuno- and Thioflavin S-costaining in the hippocampus of a rat model of AD after intravenous injection of human adipose-derived stem cells (hADSCs). Methods: Thirty-two male rats were included in the four groups of control, sham, AD and hADSCs. The hADSCs characterization was confirmed by the flow cytometry technique. Immuno- and Thioflavin S-costaining was utilized for detecting Aβ plaques in the hippocampus of a rat model of AD following injection of hADSCs. Results: Statistical analysis revealed that Aβ plaques increased significantly in the AD group compared to the control and sham groups. The administration of hADSCs significantly decreased immunoreactivity and Thio-S-positive plaques in the AD group. We also found that the plaques detected by anti-Aβ antibody (immunohistochemical staining) were significantly more than those distinguished by Thioflavin-S in all the groups. Conclusions: Results showed that hADSCs played an effective role in decreasing amyloids aggregation following migration to the hippocampus of the rat model of AD.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91038625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Hosseini, S. - Shadmehri, Zahra Rahimi Bazkhaneh, Mariam Rahmani, Nasibeh Kazemi
Background: Diabetes mellitus is a metabolic disease that leads to elevated levels of adipokines. Objectives: The aim of this study was to investigate the effect of eight weeks of combined exercise on retinol binding protein 4 (RBP4), fatty acid-binding protein (FABP) and lipocalin-2 in diabetic women. Methods: In this semi-experimental study, 18 diabetic women referred to the Bojnourd Diabetes Association were selected and divided into two groups of combined training and control. The combined training group performed resistance and endurance training for eight weeks, three sessions per week and each session for 60 minutes. The control group only had their daily routine. Before performing the pre-test and at the end of eight weeks, 5 cc of blood from the brachial vein of all the subjects was taken in fasting state. Data were analyzed by covariance, independent samples t-test and paired sample t-test. P value less than 0.05 was considered significant. Results: Eight weeks of combined training had a significant effect on reducing FABP (P = 0.02) and RBP4 (P = 0.01) in diabetic women. However, there was no significant effect on lipocalin-2 in diabetic women (P = 0.86). Conclusions: It seems to that diabetic women can implement eight weeks of combined resistance and endurance training to improve their serum levels of RBP4 and FABP.
{"title":"The Effect of Eight Weeks of Combined Exercise on Retinol Binding Protein 4, Fatty Acid Binding Protein and Lipocalin-2 in Type 2 Diabetic Women (Clinical Trial)","authors":"S. Hosseini, S. - Shadmehri, Zahra Rahimi Bazkhaneh, Mariam Rahmani, Nasibeh Kazemi","doi":"10.5812/THRITA.84879","DOIUrl":"https://doi.org/10.5812/THRITA.84879","url":null,"abstract":"Background: Diabetes mellitus is a metabolic disease that leads to elevated levels of adipokines. Objectives: The aim of this study was to investigate the effect of eight weeks of combined exercise on retinol binding protein 4 (RBP4), fatty acid-binding protein (FABP) and lipocalin-2 in diabetic women. Methods: In this semi-experimental study, 18 diabetic women referred to the Bojnourd Diabetes Association were selected and divided into two groups of combined training and control. The combined training group performed resistance and endurance training for eight weeks, three sessions per week and each session for 60 minutes. The control group only had their daily routine. Before performing the pre-test and at the end of eight weeks, 5 cc of blood from the brachial vein of all the subjects was taken in fasting state. Data were analyzed by covariance, independent samples t-test and paired sample t-test. P value less than 0.05 was considered significant. Results: Eight weeks of combined training had a significant effect on reducing FABP (P = 0.02) and RBP4 (P = 0.01) in diabetic women. However, there was no significant effect on lipocalin-2 in diabetic women (P = 0.86). Conclusions: It seems to that diabetic women can implement eight weeks of combined resistance and endurance training to improve their serum levels of RBP4 and FABP.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85644371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Intersection of Muslim Physician's Religious Beliefs and End-of-Life Care: Ethical Considerations","authors":"S. Ebrahimi, S. Ashkani-Esfahani","doi":"10.5812/THRITA.62251","DOIUrl":"https://doi.org/10.5812/THRITA.62251","url":null,"abstract":"","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84402442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Khalaj, Arash Salman Yazdi, Zary Sabet, M. Abbasi, S. Jafari, Zohreh Kaedi, S. Omidmalayeri
Background: Obesityisaccompaniedbyanumberof comorbiditiesthatgravelylowerpatients’ qualityof life;onesuchcomorbid-ityisserumlipidabnormalities. Studieshaveshownthatweightlossdecreasesserumtotalcholesterolandlow-densitylipoprotein (LDL) cholesterol and increases high-density lipoprotein (HDL) cholesterol. Bariatric surgery is one of the most recent ways to treat obesity and manage weight loss in overweight patients whose options for weight loss are limited. Objectives: Theaimof thisstudywastoassesstheeffectof bariatricsurgeryonlipidprofileof surgicalcandidatesduringthethree months of post-operative care. Methods: This prospective study was performed among 36 obese candidates of bariatric surgery at Mostafa Khomeini Hospital in Tehran, Iran from April to September of 2012. Body mass index (BMI), serum cholesterol, triglyceride, HDL and LDL levels were measured before and three months following the surgical intervention. Results: The mean age of the participants was 35.39 ± 10.32 years. Mean body mass index (BMI) of the patients before surgery was 46.74 ± 6.71 kg/m 2 , which was lowered to 38.24 ± 5.31 kg/m 2 after the intervention. Assessments showed a statistically significant increaseintheserumlevelof HDLandastatisticallysignificantdecreaseintheserumlevelof triglycerides,butnosignificantchange in the serum level of cholesterol or LDL was noted. Moreover, results showed a positive correlation between serum LDL variations and changes in BMI. Conclusions: Our findings showed that bariatric surgery improves weight loss and can help with managing or treating co-morbid illnesses through reducing triglyceride level and increasing HDL level, both of which improve patients’ long-term cardiac, hepatic and endocrine health status. Diet therapy, physical activity (aerobic primarily), behav-ioral therapy (e.g., treating underlying psychological en-ablers of eating disorders), pharmacotherapy and at last resort, surgical intervention (9). Indications for bariatric surgery include morbid obesity (a BMI higher than 40 kg/m 2 ) and severe obesity (BMI = 35 - 40 kg/m 2 ) in a patient (10).
{"title":"Serum Lipid Profile Changes After Bariatric Surgery","authors":"A. Khalaj, Arash Salman Yazdi, Zary Sabet, M. Abbasi, S. Jafari, Zohreh Kaedi, S. Omidmalayeri","doi":"10.5812/THRITA.58193","DOIUrl":"https://doi.org/10.5812/THRITA.58193","url":null,"abstract":"Background: Obesityisaccompaniedbyanumberof comorbiditiesthatgravelylowerpatients’ qualityof life;onesuchcomorbid-ityisserumlipidabnormalities. Studieshaveshownthatweightlossdecreasesserumtotalcholesterolandlow-densitylipoprotein (LDL) cholesterol and increases high-density lipoprotein (HDL) cholesterol. Bariatric surgery is one of the most recent ways to treat obesity and manage weight loss in overweight patients whose options for weight loss are limited. Objectives: Theaimof thisstudywastoassesstheeffectof bariatricsurgeryonlipidprofileof surgicalcandidatesduringthethree months of post-operative care. Methods: This prospective study was performed among 36 obese candidates of bariatric surgery at Mostafa Khomeini Hospital in Tehran, Iran from April to September of 2012. Body mass index (BMI), serum cholesterol, triglyceride, HDL and LDL levels were measured before and three months following the surgical intervention. Results: The mean age of the participants was 35.39 ± 10.32 years. Mean body mass index (BMI) of the patients before surgery was 46.74 ± 6.71 kg/m 2 , which was lowered to 38.24 ± 5.31 kg/m 2 after the intervention. Assessments showed a statistically significant increaseintheserumlevelof HDLandastatisticallysignificantdecreaseintheserumlevelof triglycerides,butnosignificantchange in the serum level of cholesterol or LDL was noted. Moreover, results showed a positive correlation between serum LDL variations and changes in BMI. Conclusions: Our findings showed that bariatric surgery improves weight loss and can help with managing or treating co-morbid illnesses through reducing triglyceride level and increasing HDL level, both of which improve patients’ long-term cardiac, hepatic and endocrine health status. Diet therapy, physical activity (aerobic primarily), behav-ioral therapy (e.g., treating underlying psychological en-ablers of eating disorders), pharmacotherapy and at last resort, surgical intervention (9). Indications for bariatric surgery include morbid obesity (a BMI higher than 40 kg/m 2 ) and severe obesity (BMI = 35 - 40 kg/m 2 ) in a patient (10).","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76207657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Universities are committed to upgrading human knowledge. Countries have different dates of establishing universities. There are old well-known universities, and new generation of universities are in the process of being established. Universities are changing in fundamental ways, moving from the traditional model of science and education to universities with vision of society leadership, creating wealth and innovation. Educationand researchbased universities are considered as the first and second generation universities (1&2GUs). Along with the rapid growth of technology and changes in communities and human needs, universities have also changed. Universities in developed countries have gradually crossed boundaries of 1&2GUs and entered a new era. Universities in these countries, while embracing their mission, have entered a new generation of academic activities, by preserving their previous functions. The formation of third generation universities (3GUs) is dependent on developed structures and infrastructures of these societies, as well as their valuable achievements in 1&2GUs. Iran has a long history of higher education. Jundishapur Academy is known as one of the oldest universities around the world. Before the Islamic Revolution, credible universities in Iran, such as the University of Tehran, Shiraz University and Polytechnic University, have been involved in academic activity at the national and international levels and considered as 1&2GUs. Since the 1970s, the number of universities and institutes of higher education has grown explosively, so that in a short time, the total number of Iranian Universities (IRUs) exceeded the total number of universities in developed European countries. The process of establishing new universities has continued until recently. Significant differences in the ranking of IRUs influence the future trend of these universities for entering next generations.
{"title":"Towards Third Generation Universities in Iran: Wish or Necessity","authors":"S. B. Jameie","doi":"10.5812/THRITA.85332","DOIUrl":"https://doi.org/10.5812/THRITA.85332","url":null,"abstract":"Universities are committed to upgrading human knowledge. Countries have different dates of establishing universities. There are old well-known universities, and new generation of universities are in the process of being established. Universities are changing in fundamental ways, moving from the traditional model of science and education to universities with vision of society leadership, creating wealth and innovation. Educationand researchbased universities are considered as the first and second generation universities (1&2GUs). Along with the rapid growth of technology and changes in communities and human needs, universities have also changed. Universities in developed countries have gradually crossed boundaries of 1&2GUs and entered a new era. Universities in these countries, while embracing their mission, have entered a new generation of academic activities, by preserving their previous functions. The formation of third generation universities (3GUs) is dependent on developed structures and infrastructures of these societies, as well as their valuable achievements in 1&2GUs. Iran has a long history of higher education. Jundishapur Academy is known as one of the oldest universities around the world. Before the Islamic Revolution, credible universities in Iran, such as the University of Tehran, Shiraz University and Polytechnic University, have been involved in academic activity at the national and international levels and considered as 1&2GUs. Since the 1970s, the number of universities and institutes of higher education has grown explosively, so that in a short time, the total number of Iranian Universities (IRUs) exceeded the total number of universities in developed European countries. The process of establishing new universities has continued until recently. Significant differences in the ranking of IRUs influence the future trend of these universities for entering next generations.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85724142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milad Kazemiha, A. Sarveazad, F. Moradi, Marjan Shariatpanahi, Farnaz Ramezanpour, M. Vosoogh, M. Mohamadpour, Maryam Doshmanziari, M. Eftekharzadeh
BackgroundAlzheimer’s disease (AD) is a progressive cognitive disorder that is generally age-related. Although there has been great research focusing on this disease, there is still a lack of reliable therapeutic methods. Amyloid-β (Aβ) peptide has a critical function in neuropathology of AD. Stem cell therapy provides treatment by improving the neuronal system in neurodegenerative disorders. Human adipose-derived stem cells (hADSCs) are the most appropriate sources of stem cells due to their safety, high proliferative potential, and easy isolation.ObjectivesThe present study was designed to evaluate the histological and behavioral alterations after intravenous administration of hADSCs in the AD rat model.MethodsIn this study, 32 male rats were used in four groups, as follows: control, sham, AD rat model, and hADSCs-treated group. We used Morris Water Maze (MWM) for evaluating behavioral changes and Nissl staining for determining the histological studies.ResultsIn this study, the AD model was confirmed by behavioral and histological analysis. Behavioral results showed that the spatial memory improved after hADSCs injection in the AD rat model while the time spent in the target quadrant was significantly higher in the hADSCs-treated group than in the AD rat model group. On the other hand, the number of dead cells significantly decreased in the hADSCs-treated group as analyzed by Nissl staining.ConclusionsOur findings revealed that hADSCs could transfer into the brain and improve memory and neuronal damage in the AD rat model.
背景:阿尔茨海默病(AD)是一种进行性认知障碍，通常与年龄有关。尽管对这种疾病已经有了大量的研究，但仍然缺乏可靠的治疗方法。淀粉样蛋白-β (a β)肽在阿尔茨海默病的神经病理中起重要作用。干细胞疗法通过改善神经退行性疾病的神经系统提供治疗。人脂肪源性干细胞(hADSCs)因其安全性、高增殖潜力和易于分离而成为最合适的干细胞来源。目的观察静脉给药hascs后AD大鼠模型的组织学和行为学改变。方法选用32只雄性大鼠，分为4组:对照组、假手术组、AD大鼠模型组和hadscs治疗组。我们使用Morris水迷宫(MWM)评估行为变化，尼氏染色测定组织学研究。结果本研究通过行为学和组织学分析证实了AD模型。行为学结果显示，在AD大鼠模型中注射hADSCs后，空间记忆得到改善，而在目标象限中停留的时间明显高于AD大鼠模型组。另一方面，通过尼氏染色分析，hadscs处理组的死细胞数量明显减少。结论研究结果表明，hascs可以转移到大脑中，改善AD大鼠模型的记忆和神经元损伤。
{"title":"WITHDRAWN: Histological and Behavioral Alterations Following hADSCs Intravenous Administration in Alzheimer’s Rat Model","authors":"Milad Kazemiha, A. Sarveazad, F. Moradi, Marjan Shariatpanahi, Farnaz Ramezanpour, M. Vosoogh, M. Mohamadpour, Maryam Doshmanziari, M. Eftekharzadeh","doi":"10.5812/THRITA.86288","DOIUrl":"https://doi.org/10.5812/THRITA.86288","url":null,"abstract":"BackgroundAlzheimer’s disease (AD) is a progressive cognitive disorder that is generally age-related. Although there has been great research focusing on this disease, there is still a lack of reliable therapeutic methods. Amyloid-β (Aβ) peptide has a critical function in neuropathology of AD. Stem cell therapy provides treatment by improving the neuronal system in neurodegenerative disorders. Human adipose-derived stem cells (hADSCs) are the most appropriate sources of stem cells due to their safety, high proliferative potential, and easy isolation.ObjectivesThe present study was designed to evaluate the histological and behavioral alterations after intravenous administration of hADSCs in the AD rat model.MethodsIn this study, 32 male rats were used in four groups, as follows: control, sham, AD rat model, and hADSCs-treated group. We used Morris Water Maze (MWM) for evaluating behavioral changes and Nissl staining for determining the histological studies.ResultsIn this study, the AD model was confirmed by behavioral and histological analysis. Behavioral results showed that the spatial memory improved after hADSCs injection in the AD rat model while the time spent in the target quadrant was significantly higher in the hADSCs-treated group than in the AD rat model group. On the other hand, the number of dead cells significantly decreased in the hADSCs-treated group as analyzed by Nissl staining.ConclusionsOur findings revealed that hADSCs could transfer into the brain and improve memory and neuronal damage in the AD rat model.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75195743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Hashemi, V. Shakeri, Haleh Mosallaei, Mona Kholdebarin, Mohamad Bakhtiari, M. Mohamadpour, S. Gholami, S. A. Yazdanparast
: Different biomarkers and signaling pathways are involved in bone development. These factors lead to different osteoprogenitor cell reactions. Proliferation, migration, and differentiation of osteoprogenitor cells is induced by different intracellular and extracellular molecular signaling pathways. As mesenchymal stem cells (MSCs) and their differentiation during repair and development of bone processes have significant roles, it is believed that sensible molecular signaling pathways involvement is vital to the development of bone formation, bone substitute materials, and bone repair. This study reviews various keys of signaling pathway that terminate proliferation, migration, and differentiation of osteoprogenitor cells.
{"title":"The Role of Signaling Pathway on Osteoprogenitor Cell Behavior and Bone Formation","authors":"M. Hashemi, V. Shakeri, Haleh Mosallaei, Mona Kholdebarin, Mohamad Bakhtiari, M. Mohamadpour, S. Gholami, S. A. Yazdanparast","doi":"10.5812/THRITA.81485","DOIUrl":"https://doi.org/10.5812/THRITA.81485","url":null,"abstract":": Different biomarkers and signaling pathways are involved in bone development. These factors lead to different osteoprogenitor cell reactions. Proliferation, migration, and differentiation of osteoprogenitor cells is induced by different intracellular and extracellular molecular signaling pathways. As mesenchymal stem cells (MSCs) and their differentiation during repair and development of bone processes have significant roles, it is believed that sensible molecular signaling pathways involvement is vital to the development of bone formation, bone substitute materials, and bone repair. This study reviews various keys of signaling pathway that terminate proliferation, migration, and differentiation of osteoprogenitor cells.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90059371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Pulp necrosis is a common consequence of extrusive luxation in mature teeth with complete apical closure. In this report, the researchers presented a case with severely extruded mature mandibular incisors (more than 5 mm), which did not lead to pulp necrosis. Case Presentation: The case was a nine-year-old female with severe dentoalveolar trauma to the anterior maxillary and mandibular region, as a result of a bicycle accident. The treatment consisted of mandibular alveolar bone and central incisors repositioning. After 18 months of follow-up, no sign of pulp necrosis was observed. Conclusions: In young patients with severe extrusive luxation and closed apices, there is the potential for pulp survival, and early endodontic treatment should be avoided until signs of pulp necrosis is observed.
{"title":"Pulp Revascularization Following Severe Extrusive Luxation Injury in Mature Permanent Mandibular Incisors: A Case Report","authors":"Fariborz Moazzami, E. Karami","doi":"10.5812/THRITA.69341","DOIUrl":"https://doi.org/10.5812/THRITA.69341","url":null,"abstract":"Introduction: Pulp necrosis is a common consequence of extrusive luxation in mature teeth with complete apical closure. In this report, the researchers presented a case with severely extruded mature mandibular incisors (more than 5 mm), which did not lead to pulp necrosis. Case Presentation: The case was a nine-year-old female with severe dentoalveolar trauma to the anterior maxillary and mandibular region, as a result of a bicycle accident. The treatment consisted of mandibular alveolar bone and central incisors repositioning. After 18 months of follow-up, no sign of pulp necrosis was observed. Conclusions: In young patients with severe extrusive luxation and closed apices, there is the potential for pulp survival, and early endodontic treatment should be avoided until signs of pulp necrosis is observed.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90754286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Knowledge of root canal morphology and variations is an essential factor to successful endodontic treatment. The incidence of a separate second palatal root in a maxillary second molar is very rare. The purpose of this case report is to describe the root canal treatment of a maxillary second molar with 4 separated roots and the variations in the internal anatomy of them, especially their palatal portion. A separate second palatal root was diagnosed in the preoperative radiograph. Careful radiograph examination and change in angulations of radiographs seems necessary for detection of normal variations.
{"title":"Root Canal Treatment of a Maxillary Second Molar with Two Palatal Roots: A Case Report","authors":"Roya Dehghan, Yasamin Ghahramani","doi":"10.5812/THRITA.69575","DOIUrl":"https://doi.org/10.5812/THRITA.69575","url":null,"abstract":"Knowledge of root canal morphology and variations is an essential factor to successful endodontic treatment. The incidence of a separate second palatal root in a maxillary second molar is very rare. The purpose of this case report is to describe the root canal treatment of a maxillary second molar with 4 separated roots and the variations in the internal anatomy of them, especially their palatal portion. A separate second palatal root was diagnosed in the preoperative radiograph. Careful radiograph examination and change in angulations of radiographs seems necessary for detection of normal variations.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85590821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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