Background: The ability of anhydrobiotic to survive long periods of stress conditions is associated with high trehalose levels found in these organisms as a responsive mechanism against stress and adverse conditions. Many methods and factors function as determinant agents of trehalose production and preservation in yeasts. Objectives: This study aimed to investigate the effect of three parameters on trehalose synthesis, including temperature, rate of feed, and time of aeration. Methods: To induce trehalose production in baker's yeast, we used an experimental design method in an industrial fermenter at the Khuzestan Yeast Company. The investigation of temperature, rate of feed, and time of aeration parameters in our recipe design were also performed after the cessation of feeding molasses. Results: The findings showed that temperature had the greatest effect on the synthesis of trehalose. Moreover, the interaction of three parameters was significantly effective for the stimulation of trehalose synthesis. We could also make a gas production surge in the dough by increasing the level of trehalose. Conclusions: We conclude that controlling the temperature and taking advantage of the interaction between temperature, rate of feed, and aeration time can help achieve the most effective trehalose synthesis and ensuing gas production in the dough.
{"title":"Effective Parameters for the Stimulation of Trehalose Synthesis in Saccharomyces cerevisiae","authors":"Karim Javidaneh, Atousa Moradzadegan","doi":"10.5812/thrita-131959","DOIUrl":"https://doi.org/10.5812/thrita-131959","url":null,"abstract":"Background: The ability of anhydrobiotic to survive long periods of stress conditions is associated with high trehalose levels found in these organisms as a responsive mechanism against stress and adverse conditions. Many methods and factors function as determinant agents of trehalose production and preservation in yeasts. Objectives: This study aimed to investigate the effect of three parameters on trehalose synthesis, including temperature, rate of feed, and time of aeration. Methods: To induce trehalose production in baker's yeast, we used an experimental design method in an industrial fermenter at the Khuzestan Yeast Company. The investigation of temperature, rate of feed, and time of aeration parameters in our recipe design were also performed after the cessation of feeding molasses. Results: The findings showed that temperature had the greatest effect on the synthesis of trehalose. Moreover, the interaction of three parameters was significantly effective for the stimulation of trehalose synthesis. We could also make a gas production surge in the dough by increasing the level of trehalose. Conclusions: We conclude that controlling the temperature and taking advantage of the interaction between temperature, rate of feed, and aeration time can help achieve the most effective trehalose synthesis and ensuing gas production in the dough.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86977063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roghayeh Roshani, F. Ashrafi, E. Moslemi, Hamid Khaledi
Background: In recent years, many studies have focused on the dysregulation of miRNA expression in cancer. These structures act as oncogenes and suppressors. In the present study, the expression levels of miR-3173-3p and miR-4772-3p were investigated in the tissue of glioblastoma multiforme (GBM) patients and healthy individuals. Methods: The present study was performed on 50 patients with GBM and 50 healthy individuals as the control group. Real-time PCR technique was used to determine the tissue levels of miR-3173-3p and miR-4772-3p. The biomarker evaluation of miR-3173-3p and miR-4772-3p was assessed using ROC curve analysis. Results: The expression level of miR-4772-3p was higher in women with GBM (P-value = 0.03). Increased concentration of miR-3173-3p in tissue of GBM patients showed a significant correlation with a final grade of disease progression (grades III and IV) (P-value = 0.007). ROC curve analysis and cut-off of 0.6939 showed that miR-4772-3p could detect the presence of malignant GBM with 88.89 sensitivity and 100.0 specificity. Conclusions: The present study reveals the potential oncogenic role of miR-4772-3p. Moreover, the progression of glioblastoma cancer in the final stages can be assessed by measuring the level of miR-4772-3p in patients’ tissue.
{"title":"Alterations of miR-4772-3pand miR-3173-3p Expression in Tissue Compared to Normal Tissue by Real-time PCR","authors":"Roghayeh Roshani, F. Ashrafi, E. Moslemi, Hamid Khaledi","doi":"10.5812/thrita-129435","DOIUrl":"https://doi.org/10.5812/thrita-129435","url":null,"abstract":"Background: In recent years, many studies have focused on the dysregulation of miRNA expression in cancer. These structures act as oncogenes and suppressors. In the present study, the expression levels of miR-3173-3p and miR-4772-3p were investigated in the tissue of glioblastoma multiforme (GBM) patients and healthy individuals. Methods: The present study was performed on 50 patients with GBM and 50 healthy individuals as the control group. Real-time PCR technique was used to determine the tissue levels of miR-3173-3p and miR-4772-3p. The biomarker evaluation of miR-3173-3p and miR-4772-3p was assessed using ROC curve analysis. Results: The expression level of miR-4772-3p was higher in women with GBM (P-value = 0.03). Increased concentration of miR-3173-3p in tissue of GBM patients showed a significant correlation with a final grade of disease progression (grades III and IV) (P-value = 0.007). ROC curve analysis and cut-off of 0.6939 showed that miR-4772-3p could detect the presence of malignant GBM with 88.89 sensitivity and 100.0 specificity. Conclusions: The present study reveals the potential oncogenic role of miR-4772-3p. Moreover, the progression of glioblastoma cancer in the final stages can be assessed by measuring the level of miR-4772-3p in patients’ tissue.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87212565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Measuring physical fitness by studying aerobic metabolism, anaerobic metabolism, and muscular strength in most sports research is one of the important indicators of professional athletes. Objectives: The aim of the present study was to compare six weeks of creatine supplementation and ginseng on the aerobic and anaerobic strength and muscle strength of the male players of the Iran national epee fencing team. Methods: This quasi-experimental study with a pretest-posttest design was performed on two experimental groups of creatine and ginseng as a double-blind study. A total of 14 male players of the national epee fencing team were assigned to two groups’ creatine supplement and ginseng supplement. The statistical significant difference was determined at P ≥ 0.05, and ANCOVA test was used to assess the differences between groups. All data were analyzed by the SPSS software version 25. Results: The results showed that the mean aerobic power in the creatine supplement group was significantly different from the ginseng supplement group (P = 0.001). In addition, the mean anaerobic control within the creatine supplement group is significantly higher than the ginseng supplement group (P = 0.001). The mean muscle strength in the creatine supplement group is significantly different from the ginseng group (P = 0.001). Higher mean aerobic power, anaerobic power, and muscle strength in the creatine supplement group, compared to the ginseng group, showed the more significant role of this supplement in raising aerobic power. Conclusions: It can be concluded that the role of creatine supplements in improving aerobic and anaerobic power and muscle strength could be more remarkable than the ginseng supplement.
{"title":"Comparison of the Effect of Creatine and Ginseng Supplementations on the Aerobic Power, Anaerobic Power, and Muscle Strength of the Male Players of the Iran National Epee Team","authors":"T. Bagherpour, Ahmad Yaghobi, N. Nemati","doi":"10.5812/thrita-128754","DOIUrl":"https://doi.org/10.5812/thrita-128754","url":null,"abstract":"Background: Measuring physical fitness by studying aerobic metabolism, anaerobic metabolism, and muscular strength in most sports research is one of the important indicators of professional athletes. Objectives: The aim of the present study was to compare six weeks of creatine supplementation and ginseng on the aerobic and anaerobic strength and muscle strength of the male players of the Iran national epee fencing team. Methods: This quasi-experimental study with a pretest-posttest design was performed on two experimental groups of creatine and ginseng as a double-blind study. A total of 14 male players of the national epee fencing team were assigned to two groups’ creatine supplement and ginseng supplement. The statistical significant difference was determined at P ≥ 0.05, and ANCOVA test was used to assess the differences between groups. All data were analyzed by the SPSS software version 25. Results: The results showed that the mean aerobic power in the creatine supplement group was significantly different from the ginseng supplement group (P = 0.001). In addition, the mean anaerobic control within the creatine supplement group is significantly higher than the ginseng supplement group (P = 0.001). The mean muscle strength in the creatine supplement group is significantly different from the ginseng group (P = 0.001). Higher mean aerobic power, anaerobic power, and muscle strength in the creatine supplement group, compared to the ginseng group, showed the more significant role of this supplement in raising aerobic power. Conclusions: It can be concluded that the role of creatine supplements in improving aerobic and anaerobic power and muscle strength could be more remarkable than the ginseng supplement.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87433035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Agility is an essential component of sport performance, especially in ball sports. It is also a significant indicator of sport skills under competitive conditions. Agility is one of the most critical factors in the sport performance of soccer players. Agility and coordination of the nervous-muscular system to produce maximum force, as an important factor of function and physical fitness, which is considered along with perception and decision making in unpredictable situations. Assessment tests for assessing agility are divided into two general areas called non-reactive agility as well as reactive agility test. Although non-reactive agility tests are superior to reactive agility tests in terms of reliability, reactive agility tests are more similar to the movement and skill pattern in soccer and can distinguish players from each other well. In reactive agility tests, the movement path of the experimenter is not predictable and not all changes in path are predetermined and exactly the movement pattern in the soccer game where the movement path of the player is not predictable and the movement path of the ball as well as the prevailing conditions in the game that determine and change of direction player at any moment. The results showed that non-reactive agility had a higher relative validity and reliability than reactive agility. This small difference was acknowledged by researchers related to the reactivity and complexity of reactive agility tests. finally a review of the above studies and findings confirms that the use of reactive agility tests is necessary to evaluate athletes
{"title":"A Review of Reactive and Non-reactive Agility Tests Concerning Neurologic Aspects","authors":"Mohammad Tajik, M. Azarbayjani, M. Peeri","doi":"10.5812/thrita-129744","DOIUrl":"https://doi.org/10.5812/thrita-129744","url":null,"abstract":": Agility is an essential component of sport performance, especially in ball sports. It is also a significant indicator of sport skills under competitive conditions. Agility is one of the most critical factors in the sport performance of soccer players. Agility and coordination of the nervous-muscular system to produce maximum force, as an important factor of function and physical fitness, which is considered along with perception and decision making in unpredictable situations. Assessment tests for assessing agility are divided into two general areas called non-reactive agility as well as reactive agility test. Although non-reactive agility tests are superior to reactive agility tests in terms of reliability, reactive agility tests are more similar to the movement and skill pattern in soccer and can distinguish players from each other well. In reactive agility tests, the movement path of the experimenter is not predictable and not all changes in path are predetermined and exactly the movement pattern in the soccer game where the movement path of the player is not predictable and the movement path of the ball as well as the prevailing conditions in the game that determine and change of direction player at any moment. The results showed that non-reactive agility had a higher relative validity and reliability than reactive agility. This small difference was acknowledged by researchers related to the reactivity and complexity of reactive agility tests. finally a review of the above studies and findings confirms that the use of reactive agility tests is necessary to evaluate athletes","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73261012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahdieh Nazari, M. Azarbayjani, S. Rahmati-Ahmadabad, M. Guerra Balic, Bryanne N. Bellovary
: Osteoporosis is one of the most important problems associated with aging. Genetic and environmental agents affect the process of reducing bone mineral density (BMD). As environmental agents, mechanical load (something which exerts an opposing force on the system; hence system needs more power to perform that work) is the important factor, which affects BMD. Studies show that a variety of exercise programs, depending on the amount of mechanical load they apply to the bone, activate the signaling pathways involved in the process of osteoblast activation and reduce osteoclast activity. The effect of physical activity (PA) on BMD is a function of the intensity, duration, and type of program used. Although the existing literature shows that regular PA increases BMD and subsequently develops its strength, there are conflicting results regarding the effectiveness of exercise programs that confirm the need for further study in this area.
{"title":"A Review of the Effects of Physical Activity (PA) on Bone Density: Relying on Iranian Studies","authors":"Mahdieh Nazari, M. Azarbayjani, S. Rahmati-Ahmadabad, M. Guerra Balic, Bryanne N. Bellovary","doi":"10.5812/thrita-128483","DOIUrl":"https://doi.org/10.5812/thrita-128483","url":null,"abstract":": Osteoporosis is one of the most important problems associated with aging. Genetic and environmental agents affect the process of reducing bone mineral density (BMD). As environmental agents, mechanical load (something which exerts an opposing force on the system; hence system needs more power to perform that work) is the important factor, which affects BMD. Studies show that a variety of exercise programs, depending on the amount of mechanical load they apply to the bone, activate the signaling pathways involved in the process of osteoblast activation and reduce osteoclast activity. The effect of physical activity (PA) on BMD is a function of the intensity, duration, and type of program used. Although the existing literature shows that regular PA increases BMD and subsequently develops its strength, there are conflicting results regarding the effectiveness of exercise programs that confirm the need for further study in this area.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84996844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sina Nikbin, S. B. Jameie, M. Azarbayjani, Nasrin Hosseini
Background: Chlorpyrifos is an organophosphate pesticide that is widely used in the world. Exposure to chlorpyrifos is associated with some problems in cognitive functions, such as learning and memory. Caspase-3 is a cysteine protease that is activated in response to several apoptotic stimuli and triggers some proteolytic events, cell death, and neurodegeneration. Objectives: The aim of the present study was to clear potential mechanisms related to chlorpyrifos neurotoxicity through caspase-3 alteration and passive avoidance memory function. Methods: Male adult rats were randomly divided into the control, sham, and chlorpyrifos groups (eight rats in each group). The chlorpyrifos group received an intraperitoneal injection of chlorpyrifos (3 mg/kg/5 days) dissolved in dimethyl sulfoxide for two consecutive weeks. The caspase-3 levels in the hippocampus were assessed by the western blot technique, and also the passive avoidance task was used for memory evaluation. Results: Our findings showed that chlorpyrifos treatment markedly increased caspase-3 levels in the hippocampus and also increased the time spent in the dark chamber 24 h and one week after receiving foot shock in the chlorpyrifos group. Conclusions: Organophosphate pesticides exposure can impair passive avoidance memory, and high levels of caspase-3 in the hippocampus are proposed as a possible reason for neuronal toxicity and memory impairment.
{"title":"The Effects of Chlorpyrifos on Hippocampal Caspase-3 Levels and Passive Avoidance Memory in Rats","authors":"Sina Nikbin, S. B. Jameie, M. Azarbayjani, Nasrin Hosseini","doi":"10.5812/thrita-123356","DOIUrl":"https://doi.org/10.5812/thrita-123356","url":null,"abstract":"Background: Chlorpyrifos is an organophosphate pesticide that is widely used in the world. Exposure to chlorpyrifos is associated with some problems in cognitive functions, such as learning and memory. Caspase-3 is a cysteine protease that is activated in response to several apoptotic stimuli and triggers some proteolytic events, cell death, and neurodegeneration. Objectives: The aim of the present study was to clear potential mechanisms related to chlorpyrifos neurotoxicity through caspase-3 alteration and passive avoidance memory function. Methods: Male adult rats were randomly divided into the control, sham, and chlorpyrifos groups (eight rats in each group). The chlorpyrifos group received an intraperitoneal injection of chlorpyrifos (3 mg/kg/5 days) dissolved in dimethyl sulfoxide for two consecutive weeks. The caspase-3 levels in the hippocampus were assessed by the western blot technique, and also the passive avoidance task was used for memory evaluation. Results: Our findings showed that chlorpyrifos treatment markedly increased caspase-3 levels in the hippocampus and also increased the time spent in the dark chamber 24 h and one week after receiving foot shock in the chlorpyrifos group. Conclusions: Organophosphate pesticides exposure can impair passive avoidance memory, and high levels of caspase-3 in the hippocampus are proposed as a possible reason for neuronal toxicity and memory impairment.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82927282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Parsa-Lisar, Hasan Matinhomaei, M. Azarbayjani
: Chlorpyrifos is an organophosphate toxin used to control agricultural pests that cause oxidative stress, apoptosis, and cell destruction in various body tissues, including the heart. The expression of Wnt, TGFβ, and beta-catenin plays a crucial role in cardiac fibrosis development. No study has investigated changes in the function of these genes following physical activity and eugenol supplementation in chlorpyrifos intoxication. The present study investigated the independent and interactive effect of aerobic exercise and eugenol supplementation on the Wnt, TGFβ, and beta-catenin gene expression in the heart tissue of rats poisoned with chlorpyrifos. Forty-two male rats were divided into seven groups: healthy control, healthy receiving DMSO as chlorpyrifos toxin solvent, healthy receiving corn oil as eugenol solvent, poisoned control, aerobic exercise poisoning, eugenol poisoning, aerobic poisoning, and eugenol poisoning. The expression of the desired genes in the hearts of rats was measured after providing the intervention. Data were analyzed using the one-way analysis of variance and Tukey's post hoc tests. Statistical significance was considered when P ≤ 0.05. Poisoning significantly increased the Wnt, TGFβ, and beta-catenin gene expression in the heart tissue. The use of exercise and supplementation reduced the Wnt, TGFβ, and beta-catenin gene expression, each independently, in the hearts of poisoned rats. Exercise-eugenol interaction did not significantly reduce the gene expression than exercise or supplementation alone. Overall, the present study showed the positive role of exercise and eugenol in reducing chronic cardiac toxicity on Wnt, TGFβ, and beta-catenin gene expression.
{"title":"The Effect of Aerobic Exercise Training and Eugenol Supplementation on the Wnt, TGF-β, and Beta-Catenin gene Expression in Myocardial Tissue of Poisoned Rats Induced by Chlorpyrifos","authors":"Fatemeh Parsa-Lisar, Hasan Matinhomaei, M. Azarbayjani","doi":"10.5812/thrita-118263","DOIUrl":"https://doi.org/10.5812/thrita-118263","url":null,"abstract":": Chlorpyrifos is an organophosphate toxin used to control agricultural pests that cause oxidative stress, apoptosis, and cell destruction in various body tissues, including the heart. The expression of Wnt, TGFβ, and beta-catenin plays a crucial role in cardiac fibrosis development. No study has investigated changes in the function of these genes following physical activity and eugenol supplementation in chlorpyrifos intoxication. The present study investigated the independent and interactive effect of aerobic exercise and eugenol supplementation on the Wnt, TGFβ, and beta-catenin gene expression in the heart tissue of rats poisoned with chlorpyrifos. Forty-two male rats were divided into seven groups: healthy control, healthy receiving DMSO as chlorpyrifos toxin solvent, healthy receiving corn oil as eugenol solvent, poisoned control, aerobic exercise poisoning, eugenol poisoning, aerobic poisoning, and eugenol poisoning. The expression of the desired genes in the hearts of rats was measured after providing the intervention. Data were analyzed using the one-way analysis of variance and Tukey's post hoc tests. Statistical significance was considered when P ≤ 0.05. Poisoning significantly increased the Wnt, TGFβ, and beta-catenin gene expression in the heart tissue. The use of exercise and supplementation reduced the Wnt, TGFβ, and beta-catenin gene expression, each independently, in the hearts of poisoned rats. Exercise-eugenol interaction did not significantly reduce the gene expression than exercise or supplementation alone. Overall, the present study showed the positive role of exercise and eugenol in reducing chronic cardiac toxicity on Wnt, TGFβ, and beta-catenin gene expression.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90522638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Polycystic ovary syndrome (PCOS) is the most common disease associated with chronic anovulation that affects 4 - 6% of women of reproductive age. Objectives: This study aimed to assess the correlation of luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio with body mass index (BMI), hirsutism, age, and main clinical symptoms of PCOS in women. Methods: We compared hirsutism, irregular menses, menstrual pain, LH, FSH, and LH/FSH between 400 women diagnosed with PCOS based on Rotterdam Criteria and 500 healthy controls. Moreover, the relationships between all these variables were investigated. The data were evaluated by the Mann-Whitney test, chi-square test, and correlation coefficient. Results: In this study, mean weight and BMI, as well as the percentage of clinical factors, namely hirsutism, irregular menstruation, and menstrual pain in the PCOS group, were significantly higher than in the control group (P ≤ 0.001). In addition, the mean of LH, FSH, and LH/FSH in women with PCOS was significantly higher than the control group (P≤0.001). Our results showed a significant negative relationship between age and LH/FSH in the PCOS group (r = -0.106, P = 0.034). Conclusions: According to the findings of this study, LH/FSH ratio had a significant negative correlation with age. However, no relationship was observed between LH/FSH ratio and BMI.
背景:多囊卵巢综合征(PCOS)是与慢性无排卵相关的最常见疾病，影响4 - 6%的育龄妇女。目的:本研究旨在探讨促黄体生成素(LH)/促卵泡激素(FSH)比值与女性多囊卵巢综合征(PCOS)体重指数(BMI)、多毛症、年龄及主要临床症状的相关性。方法:我们比较了400名根据鹿特丹标准诊断为PCOS的女性和500名健康对照者的多毛、月经不规律、月经疼痛、LH、FSH和LH/FSH。此外，还研究了这些变量之间的关系。采用Mann-Whitney检验、卡方检验和相关系数对数据进行评价。结果:本研究中，PCOS组患者的平均体重、BMI以及临床因素多毛、月经不调、月经疼痛的百分比均显著高于对照组(P≤0.001)。PCOS患者LH、FSH、LH/FSH均值均显著高于对照组(P≤0.001)。结果显示PCOS组年龄与LH/FSH呈显著负相关(r = -0.106, P = 0.034)。结论:根据本研究结果，LH/FSH比值与年龄呈显著负相关。然而，没有观察到LH/FSH比值与BMI之间的关系。
{"title":"Correlations Between Gonadotropin Hormones and the Manifestations of Polycystic Ovary Syndrome","authors":"Davoud Fazli, Seyed Peyman Moghaddasi","doi":"10.5812/thrita-117396","DOIUrl":"https://doi.org/10.5812/thrita-117396","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is the most common disease associated with chronic anovulation that affects 4 - 6% of women of reproductive age. Objectives: This study aimed to assess the correlation of luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio with body mass index (BMI), hirsutism, age, and main clinical symptoms of PCOS in women. Methods: We compared hirsutism, irregular menses, menstrual pain, LH, FSH, and LH/FSH between 400 women diagnosed with PCOS based on Rotterdam Criteria and 500 healthy controls. Moreover, the relationships between all these variables were investigated. The data were evaluated by the Mann-Whitney test, chi-square test, and correlation coefficient. Results: In this study, mean weight and BMI, as well as the percentage of clinical factors, namely hirsutism, irregular menstruation, and menstrual pain in the PCOS group, were significantly higher than in the control group (P ≤ 0.001). In addition, the mean of LH, FSH, and LH/FSH in women with PCOS was significantly higher than the control group (P≤0.001). Our results showed a significant negative relationship between age and LH/FSH in the PCOS group (r = -0.106, P = 0.034). Conclusions: According to the findings of this study, LH/FSH ratio had a significant negative correlation with age. However, no relationship was observed between LH/FSH ratio and BMI.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"85 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87674929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad-Ali Zeratgar, A. Ghanbari-Niaki, S. Rahmati-Ahmadabad
Background: Nowadays, circular training has become more common than traditional training in wrestling. Objectives: This study aimed to compare the effects of 6 weeks of traditional and circular wrestling training on blood lactate, lactate dehydrogenase (LDH), glucose, and insulin concentrations in young male wrestlers. Methods: Twenty-seven young male wrestlers were randomly divided into 3 groups (ie, traditional wrestling training, circular wrestling training, and control groups) and performed interventions based on the group name for 6 weeks. Blood samples were taken from all subjects 48 hours before and 48 hours after the interventions and sent to a laboratory for analysis. Blood concentrations of lactate, LDH, glucose, and insulin were measured by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using multivariate analysis of covariance (MANCOVA) and suitable post hoc test. Results: Traditional training significantly increased plasma lactate concentrations of wrestlers (P = 0.01) and had no significant effect on their serum LDH, insulin, and glucose concentrations (P > 0.05). Circular training significantly increased plasma lactate (P = 0.03) and serum insulin (P = 0.004) concentrations and had no significant effect on serum LDH and glucose concentrations (P > 0.05). Conclusions: These 2 types of training have a similar effect on the measured variables; however, it seems that circular training has a more significant effect on the measured variables than traditional training, which can probably be attributed to the use of more lactic energy resources and apparatus in circular training, which in turn can be used in preparation.
{"title":"Comparison of the Effects of 6 Weeks of Traditional and Wrestling-Technique-Based Circuit Training on the Blood Levels of Lactate, Lactate Dehydrogenase, Glucose, and Insulin in Young Male Wrestlers","authors":"Mohammad-Ali Zeratgar, A. Ghanbari-Niaki, S. Rahmati-Ahmadabad","doi":"10.5812/thrita.122183","DOIUrl":"https://doi.org/10.5812/thrita.122183","url":null,"abstract":"Background: Nowadays, circular training has become more common than traditional training in wrestling. Objectives: This study aimed to compare the effects of 6 weeks of traditional and circular wrestling training on blood lactate, lactate dehydrogenase (LDH), glucose, and insulin concentrations in young male wrestlers. Methods: Twenty-seven young male wrestlers were randomly divided into 3 groups (ie, traditional wrestling training, circular wrestling training, and control groups) and performed interventions based on the group name for 6 weeks. Blood samples were taken from all subjects 48 hours before and 48 hours after the interventions and sent to a laboratory for analysis. Blood concentrations of lactate, LDH, glucose, and insulin were measured by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using multivariate analysis of covariance (MANCOVA) and suitable post hoc test. Results: Traditional training significantly increased plasma lactate concentrations of wrestlers (P = 0.01) and had no significant effect on their serum LDH, insulin, and glucose concentrations (P > 0.05). Circular training significantly increased plasma lactate (P = 0.03) and serum insulin (P = 0.004) concentrations and had no significant effect on serum LDH and glucose concentrations (P > 0.05). Conclusions: These 2 types of training have a similar effect on the measured variables; however, it seems that circular training has a more significant effect on the measured variables than traditional training, which can probably be attributed to the use of more lactic energy resources and apparatus in circular training, which in turn can be used in preparation.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80096199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Shahraki, M. Shakiba, Melika Gholampour Yazdi, Narjes Sargolzaie
Background: End-stage renal disease (ESRD) is the stage of renal failure that requires renal replacement therapy such as hemodialysis. Despite the beneficial effects of hemodialysis on patient survival and progress in the treatment of various disorders in these patients, patients still suffer from numerous complications, such as neurological and cognitive disorders, which do not improve with dialysis. Objectives: This study aimed to evaluate cognitive impairment in hemodialysis patients in Zahedan, Iran, and design a model to predict the risk. Methods: This cross-sectional study was performed on 114 hemodialysis patients in Zahedan. Due to the socioeconomic status of the people of this region and the lack of a similar study in this part of Iran, the mini-mental state examination (MMSE) was performed. An information checklist, including age, gender, lifetime frequency of hemodialysis, and duration of hemodialysis, was completed by the investigator. Results: The MMSE score showed that cognitive impairment was common in ESRD patients, and its prevalence was significantly higher in elderly patients. Patients' cognitive function was significantly related to the lifetime frequency and duration of dialysis. Based on these results, we designed a model to predict the likelihood of cognitive impairment. Conclusions: The results show that cognitive impairment is a common problem among ESRD patients. Dementia is associated with multiple risks such as death, withdrawal from dialysis, hospitalization, and exacerbation of disability in ESRD patients. Therefore, effective recognition and management of these disorders can improve clinical care.
{"title":"Cognitive Impairment and Related Causes in Hemodialysis Patients","authors":"E. Shahraki, M. Shakiba, Melika Gholampour Yazdi, Narjes Sargolzaie","doi":"10.5812/thrita.115833","DOIUrl":"https://doi.org/10.5812/thrita.115833","url":null,"abstract":"Background: End-stage renal disease (ESRD) is the stage of renal failure that requires renal replacement therapy such as hemodialysis. Despite the beneficial effects of hemodialysis on patient survival and progress in the treatment of various disorders in these patients, patients still suffer from numerous complications, such as neurological and cognitive disorders, which do not improve with dialysis. Objectives: This study aimed to evaluate cognitive impairment in hemodialysis patients in Zahedan, Iran, and design a model to predict the risk. Methods: This cross-sectional study was performed on 114 hemodialysis patients in Zahedan. Due to the socioeconomic status of the people of this region and the lack of a similar study in this part of Iran, the mini-mental state examination (MMSE) was performed. An information checklist, including age, gender, lifetime frequency of hemodialysis, and duration of hemodialysis, was completed by the investigator. Results: The MMSE score showed that cognitive impairment was common in ESRD patients, and its prevalence was significantly higher in elderly patients. Patients' cognitive function was significantly related to the lifetime frequency and duration of dialysis. Based on these results, we designed a model to predict the likelihood of cognitive impairment. Conclusions: The results show that cognitive impairment is a common problem among ESRD patients. Dementia is associated with multiple risks such as death, withdrawal from dialysis, hospitalization, and exacerbation of disability in ESRD patients. Therefore, effective recognition and management of these disorders can improve clinical care.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84193972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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