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Unsual Clinical Features Of Miller-Fisher Syndrome: Case Report Miller-Fisher综合征的异常临床特征:1例报告
Pub Date : 2009-12-31 DOI: 10.5580/3c
Punatar Sb, Jogi Vm, Malasana Vr
Miller Fisher Syndrome is an uncommon clinical variant of Guillain-Barre syndrome and has rarer variants. The classic triad is opthalmoplegia, ataxia and areflexia. But rarer clinical features have been described. Here we describe a case in which all ocular muscles were not involved simultaneously and pupils were involved right from the beginning. We also describe the clinical course of the disease.
米勒-费雪综合征是格林-巴利综合征的一种罕见的临床变体,其变体更为罕见。典型的三联症是眼麻痹、共济失调和反射性屈曲。但罕见的临床特征已被描述。这里我们描述了一个病例,所有的眼肌不是同时受累,瞳孔从一开始就受累。我们还描述了疾病的临床病程。
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引用次数: 0
Search for Human Herpesvirus-6 in Mesial Temporal Lobe Epilepsy Surgical Brain Resections 在内侧颞叶癫痫手术脑切除中寻找人类疱疹病毒-6
Pub Date : 2009-12-31 DOI: 10.5580/15b6
M. K. Hole, S. Rider, Paul Kwon, R. Worth, Liang Cheng, E. Hattab, Tina Y. Fodrie, V. Salanova, D. Sokol
Human Herpesvirus-6 (HHV-6) causes roseola infantum and has been associated with multiple sclerosis, seizures, meningitis, and meningoencephalitis. A 2003 study isolated HHV-6 DNA in astrocyte-resembling cells of temporal lobe surgical brain tissue resections in four of eight patients with mesial temporal lobe epilepsy (MTLE). This suggests that the initial infection or reactivation of HHV-6 in astrocytes plays a role in the development of MTLE. We sought to replicate this finding in 18 patients undergoing lobectomy for medically refractory seizures with history of roseola and MTLE. We found no evidence of HHV-6 DNA in temporal lobe specimens of 18 patients with MTLE.
人类疱疹病毒-6 (HHV-6)引起婴儿红疹,并与多发性硬化症、癫痫、脑膜炎和脑膜脑炎有关。2003年的一项研究从8例内侧颞叶癫痫(MTLE)患者中4例手术切除的颞叶脑组织的星形细胞样细胞中分离出HHV-6 DNA。这表明星形胶质细胞中HHV-6的初始感染或再激活在MTLE的发展中起作用。我们试图在18例接受肺叶切除术的难治性癫痫患者中复制这一发现,这些患者有玫瑰疹和MTLE病史。我们在18例MTLE患者的颞叶标本中未发现HHV-6 DNA的证据。
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引用次数: 0
Record review of patients with Brain Abscess and Empyema at Chris Hani Baragwanath Hospital. Chris Hani Baragwanath医院脑脓肿和脓胸患者的记录回顾。
Pub Date : 2009-12-31 DOI: 10.5580/21dc
Katherine Gradidge, D. Franzsen
Studies on brain abscess (BA) and Empyema are not routinely focused on the role of occupational therapy (OT) with these patients. There is a paucity of literature on deficits resulting from BA and Empyema other than hemiplegia. This study used a retrospective record review to determine the relationship between BA, Empyema, and resultant physical and psychosocial dysfunction. Patients with BA generally had more significant deficits than those with Empyema for both physical and psychosocial performance components. Hemiplegia was the most common physical deficit found with the most common psychosocial deficit being body concept. Remediation of these deficits falls within the scope of OT which is recommended for this patient population.
对脑脓肿(BA)和脓胸的研究通常不关注职业治疗(OT)在这些患者中的作用。除了偏瘫之外,关于BA和脓胸导致的缺陷的文献很少。本研究采用回顾性记录来确定BA、脓胸和由此产生的身体和心理功能障碍之间的关系。BA患者通常比脓胸患者在生理和心理表现方面有更显著的缺陷。偏瘫是最常见的身体缺陷,最常见的社会心理缺陷是身体概念。这些缺陷的补救属于推荐用于该患者群体的OT范围。
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引用次数: 2
Age Related Changes Of Corpus Callosum By MRI In Females 女性胼胝体年龄相关的MRI变化
Pub Date : 2009-12-31 DOI: 10.5580/18a1
Ekta Gupta, R. Lalwani, C. Babu, S. Aneja
The morphologic characteristics of brain in humans appear to be sensitive to the effects of both age and sex, and data suggest that these 2 variables may interact over the life span to influence brain size. These morphometrical data can provide a useful context to interpret changes in regional brain structure associated with aging. The corpus callosum is the largest commissure of the brain. It is seen as thick, curved white band on medial surface of sagittaly bisected brain. It is 10 cm long and consist of the rostrum, genu, trunk and splenium. The present study was carried out on 120 females, between the age group of 20-85 years who visited the OPD of Department of radio-diagnosis of SVBP Hospital and NMC Sky Imaging Centre, LLRM Medical College, Meerut. They were studied for various parameters of corpus callosum in mid-sagittal plane by Magnetic Resonance Imaging .Different parts of corpus callosum were compared in adult and senile age groups. Progressive chronological decrease was found with age especially in the region of genu and rostrum, also the maximum width of corpus callosum significantly decreased with increasing age.
人类大脑的形态特征似乎对年龄和性别的影响都很敏感,数据表明,这两个变量可能在一生中相互作用,影响大脑的大小。这些形态计量学数据可以为解释与衰老相关的区域大脑结构的变化提供有用的背景。胼胝体是大脑最大的连接体。在矢状切分的大脑内侧可见厚的、弯曲的白色带。它长10厘米,由颈、膝、干和脾组成。本研究对120名年龄在20-85岁之间的女性进行了研究,她们曾在密鲁特LLRM医学院SVBP医院放射诊断科和NMC天空成像中心的门诊就诊。应用磁共振成像技术对中矢状面胼胝体各参数进行了研究,并对成年和老年胼胝体的不同部位进行了比较。随着年龄的增长,胼胝体的最大宽度随年龄的增长而明显减小,尤其是在膝和坛区,胼胝体的最大宽度也随着年龄的增长而明显减小。
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引用次数: 4
Awareness Might Be Assessed By Quatitive Electric Tomoggraphy In Persistent Vegetative State And Minimally Conscious State 在持续植物人状态和最低意识状态下,定量电断层扫描可以评估意识
Pub Date : 2009-12-31 DOI: 10.5580/e47
C. Machado, H. Foyaca-Sibat
Monti et al. published interesting results using fMRI for assessing willful responses in PVS and MCS. We studied an 8-year-old boy diagnosed as PVS after repeated clinical examinations. We investigated whether there was brain activation in response to hearing his mother’s voice, compared with the voices of unknown women, using quantitative electric tomography (QEEGt). We found functional activation for EEG frequencies from 14-58 Hz, with a peak at 33.2 Hz (gamma band). QEEGt maps showed brain activation localized in the lateral and posterior regions of the left cerebral hemisphere (Figure 1). No brain activation was found in the patient hearing the voices of unknown women. Figure 1 Figure 1. Axial QEEGt maps illustrate patient’s brain activation in response to hearing his mother’s voice, localized in the left lateral and posterior region of the left cerebral hemisphere Our results suggested recognition of the mother’s voice in a PVS. QEEGt directly reflects immediate neuronal activation, because this technique entails a higher time resolution, compared with other neuroimaging techniques depending of CBF changes. 2-4 Therefore, in some patients bedside clinical assessments may not reveal awareness, regardless of how methodically they are applied. 1,2 These findings launch new ethical and practical implications for the management of these patients. 1,2,5 References 1. Monti MM, Vanhaudenhuyse A, Coleman MR et al. Willful Modulation of Brain Activity in Disorders of Consciousness. N Engl J Med 2010; 2. Machado C, Korein J, Aubert E et al. Recognizing a mother's voice in the persistent vegetative state. Clinical EEG and Neuroscience 2007; 38:124-26. 3. Machado C, Cuspineda E, Valdes P et al. Assessing acute middle cerebral artery ischemic stroke by quantitative electric tomography. Clin EEG Neurosci 2004; 35:116-24. 4. Li M, Lu BL. Emotion classification based on gamma- band EEG. Conf Proc IEEE Eng Med Biol Soc 2009;1:1223-26. 5. Owen AM, Coleman MR. Detecting awareness in the vegetative state. Ann N Y Acad Sci. 2008; 1129:130-38. Awareness Might Be Assessed By Quatitive Electric Tomoggraphy In Persistent Vegetative State And Minimally Conscious State 2 of 2 Author Information Calixto Machado Institute of Neurology and Neurosurgery, Havana, Cuba Humberto Foyaca-Sibat Walter Sisulu University, Mthatha, South Africa
Monti等人发表了一些有趣的结果,利用fMRI来评估PVS和MCS的故意反应。我们研究了一名经反复临床检查诊断为PVS的8岁男孩。我们使用定量电断层扫描(QEEGt)研究了听到他母亲的声音与不认识的女性的声音相比,他的大脑是否会被激活。我们发现脑电图频率在14-58 Hz范围内的功能激活,在33.2 Hz(伽马波段)处达到峰值。QEEGt图显示大脑激活位于左大脑半球的外侧和后部区域(图1)。在听到未知女性声音的患者中没有发现大脑激活。图1图1。轴向QEEGt图显示了患者在听到母亲声音时的大脑激活,该区域位于左大脑半球的左侧外侧和后部。我们的研究结果表明,PVS可以识别母亲的声音。QEEGt直接反映神经元的即时激活,因为与其他依赖CBF变化的神经成像技术相比,该技术需要更高的时间分辨率。2-4因此,在一些患者中,无论如何系统地应用床边临床评估,都可能无法揭示意识。1,2这些发现为这些患者的管理提供了新的伦理和实践意义。1、2、5参考文献Monti MM, Vanhaudenhuyse A, Coleman MR等。意识障碍中大脑活动的故意调节。中华医学杂志2010;2. 马夏多,李晓明,李晓明,等。在持续的植物人状态下辨认出母亲的声音。临床脑电图与神经科学2007;38:124-26。3.马夏多C, Cuspineda E, Valdes P等。定量电断层成像评价急性大脑中动脉缺血性卒中。临床脑电图神经科学2004;35:116-24。4. 李敏,陆宝玲。基于伽马波段脑电图的情绪分类。中国生物医学工程学报,2009;1(1):1223- 1226。5. 欧文先生,科尔曼先生,在植物人状态下检测意识。安宁英。学术科学。2008;1129:130-38。在持续植物人状态和最低意识状态下,定量电断层扫描可以评估意识2 of 2作者信息
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引用次数: 0
Disseminated Cryptococcosis: Case report 播散性隐球菌病1例
Pub Date : 2008-12-31 DOI: 10.5580/1ac6
G. Ocaña, JC Ortiz Sablon, I. O. Tamayo
Life-threatening infections caused by the Cryptococcus neoformans have been increasing steadily over the past 20 years because of the onset of AIDS and the expanded use of immunosuppressive drugs. The incidence of Cryptococcal infection is higher among patients living with AIDS in Africa and Southeast Asia. After the lungs and CNS infection, the next most commonly involved organs in disseminated cryptococcosis are the skin, prostate and medullary cavity of the bones. The diagnosis is established by the isolation of organism in culture, histopathology, or detection of its polysaccharide capsular antigen. The acute mortality rate for HIV infected patients is 10-25%; most deaths are attributable to cryptococcal meningitis.
在过去的20年里,由于艾滋病的出现和免疫抑制药物的广泛使用,由新型隐球菌引起的危及生命的感染一直在稳步增加。隐球菌感染在非洲和东南亚的艾滋病患者中发病率较高。在肺部和中枢神经系统感染之后,播散性隐球菌病最常累及的器官是皮肤、前列腺和骨髓腔。诊断是通过培养、组织病理学或检测其多糖荚膜抗原来建立的。艾滋病毒感染者的急性死亡率为10-25%;大多数死亡可归因于隐球菌脑膜炎。
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引用次数: 1
Application of Greek Stroke Score in Ethiopia. A validation study 希腊中风评分在埃塞俄比亚的应用。验证性研究
Pub Date : 2008-12-31 DOI: 10.5580/2653
T. Berhe, G. Zenebe, Y. Melkamu
Objective: To assess the applicability of Greek stroke score in Addis Abeba, Ethiopia. Method: Using a cross sectional study design, acute stroke patients who had CT scan done were evaluated with Greek stroke score. Sensitivity, specificity, positive & negative predictive values were tested.Result: Out of 91 patients enrolled in the study 42 patients had cerebral infarction and 49 patients had intracerebral hemorrhage by CT scan. The Greek score was uncertain (equivocal) in 36 (39.6%) patients. The sensitivity, specificity, positive & negative predictive values were 0.778 (95% CI, 0.5730.906), 0.893 (95% CI, 0.706-0.972), 0.875 (95% CI, 0.665-0.967), 0.806 (955 CI, 0.619-0.919), respectively. Its overall accuracy was 83.6%.Conclusion: The Greek stroke score has good specificity for diagnosis of intracerebral hemorrhage, but has high percentage of uncertain cases hence could not be recommended to guide physicians in the management of stroke.
目的:评价希腊脑卒中评分在埃塞俄比亚首都亚的斯亚贝巴的适用性。方法:采用横断面研究设计,对行CT扫描的急性脑卒中患者进行希腊脑卒中评分。检测敏感性、特异性、阳性预测值和阴性预测值。结果:91例入组患者中,CT扫描显示脑梗死42例,脑出血49例。36例(39.6%)患者的希腊评分不确定(模棱两可)。敏感性、特异性、阳性预测值和阴性预测值分别为0.778 (95% CI, 0.5730.906)、0.893 (95% CI, 0.706 ~ 0.972)、0.875 (95% CI, 0.665 ~ 0.967)、0.806 (955 CI, 0.619 ~ 0.919)。其总体准确率为83.6%。结论:希腊脑卒中评分对脑出血的诊断特异性较好,但不确定病例的比例较高,不能作为指导医生对脑卒中进行治疗的依据。
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引用次数: 5
A very rare case report of late presentation of Moya moya syndrome in a child with history of tubercular meningitis. A case report 一个非常罕见的病例报告晚提出莫亚莫亚综合征的儿童结核性脑膜炎的历史。病例报告
Pub Date : 2008-12-31 DOI: 10.5580/289b
K. Umesh, K. Shilpa
Moya Moya is a rare idiopathic progressive vaso-occlusive disease characterized by irreversible occlusion of main blood vessels to the brain as they enter into the skull. The occlusive process stimulates the development of an extensive network of enlarged basal, transcortical and transdural collateral vessels. The blockage tends to cause strokes or seizures. The process of narrowing of cerebral vessels seems to be a reaction of brain blood vessels to a wide variety of external stimuli, injuries or genetic defects. We present a case of progressive vasculopathy in a 10 year old girl with history of tuberculous meningitis (TBM) in the infancy and which is being rarely described in pediatric population in which tubercular meningitis is still very much common in this part of world.
莫亚病是一种罕见的特发性进行性血管闭塞性疾病,其特征是进入颅骨的通往大脑的主要血管不可逆转地闭塞。闭塞过程刺激了基底、经皮质和经硬膜侧支血管扩大的广泛网络的发展。这种堵塞容易导致中风或癫痫发作。脑血管狭窄的过程似乎是脑血管对各种外部刺激、损伤或遗传缺陷的反应。我们提出了一例进行性血管病变的10岁女孩结核性脑膜炎(TBM)的历史,在婴儿期,这是很少被描述在儿童人口结核性脑膜炎仍然是非常常见的在这个部分的世界。
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引用次数: 2
A Comparative Clinical Trial of Rose Petal (Gul Gulaab), Rose Hydrosol Diluted (Arq Gulaab), and Rose Hydrosol (Ruh Gulaab) in Insomnia. 玫瑰花瓣(Gul Gulaab)、稀释玫瑰纯露(Arq Gulaab)、玫瑰纯露(Ruh Gulaab)治疗失眠的临床比较研究。
Pub Date : 2008-12-31 DOI: 10.5580/22ec
U. Jahangir, S. Urooj, A. Shah, M. Ishaaq, A. Habib
Insomnia or lack of sleep is a sleeping disorder that is taking the form of an epidemic worldwide with competitive life replacing the traditional lifestyles. Therefore a lot is in turmoil including sleep. The National Sleep Foundation estimates 47 million American adults to be at risk of injury and physical and emotional difficulty because they do not get enough sleep. Presently no specific treatment is available for this ailment. The sleeping pills and other sedatives available in the market cause psychological and physical dependence besides they are also reported to cause some memory and conginitive disturbances. As such a study was conducted to evaluate the response of gul gulaab (powdered rose petals), arq gulaab (rose distillate diluted) and ruh gulaab (rose distillate) given through oral route in 36 cases.The present article deals with the response of these patients to the three different types of rose mediated medications.
失眠或睡眠不足是一种睡眠障碍,在世界范围内以一种流行病的形式出现,竞争生活取代了传统的生活方式。因此,包括睡眠在内的很多东西都处于混乱之中。美国国家睡眠基金会估计,由于睡眠不足,4700万美国成年人面临受伤、身体和情绪困难的风险。目前还没有针对这种疾病的特殊治疗方法。市场上可买到的安眠药和其他镇静剂不仅会引起心理和生理上的依赖,而且据报道还会引起一些记忆和认知障碍。本研究对36例患者口服玫瑰花瓣粉、玫瑰蒸馏液稀释剂和玫瑰蒸馏液ruh gulaab的疗效进行了评价。本文讨论了这些患者对三种不同类型的玫瑰介导药物的反应。
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引用次数: 2
Variables Affecting Memory Deficits in Relapsing-Remitting Multiple Sclerosis 影响复发缓解型多发性硬化症患者记忆缺陷的变量
Pub Date : 2008-12-31 DOI: 10.5580/fb9
T. Panou, P. Simos, V. Mastorodemos, Ch Fassaraki, A. Plaitakis
Memory impairment features prominently among the cognitive problems caused by Multiple Sclerosis (MS). In the present study 33 patients diagnosed with the relapsing-remitting form of MS and 30 controls matched on age, education, gender, and IQ were tested on measures of verbal learning (immediate and delayed recall of word lists and short stories), and lexical retrieval from long term memory (verbal fluency tests). MS patients demonstrated significant deficits in both immediate and delayed recall ability as well as in verbal fluency. Group differences in delayed verbal recall depended upon initial encoding ability of the same material, with the exception of delayed recall of the Wechsler Memory Scale Logical Memory story B. This finding may have been due to greater susceptibility of MS patients to the effects of proactive interference. Verbal fluency deficits appeared to depend upon a general impairment in the speed of information processing.
在多发性硬化症(MS)引起的认知问题中,记忆障碍是一个突出的特点。在本研究中,33名被诊断为复发缓解型多发性硬化症的患者和30名年龄、教育程度、性别和智商相匹配的对照组进行了语言学习(单词列表和短篇故事的即时和延迟回忆)和长期记忆词汇检索(语言流畅性测试)的测试。多发性硬化症患者在即时和延迟回忆能力以及语言流畅性方面都表现出明显的缺陷。除了韦氏记忆量表逻辑记忆故事b的延迟回忆外,延迟言语回忆的组间差异取决于相同材料的初始编码能力。这一发现可能是由于MS患者更容易受到主动干扰的影响。语言流畅性缺陷似乎取决于信息处理速度的普遍损害。
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引用次数: 5
期刊
The Internet Journal of Neurology
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