Transplantation proceedings最新文献

{"title":"Comparison of Double Renal Artery Anastomosis With Single Renal Artery Anastomosis in Kidney Transplant Recipients; Is There Any Effect on Graft Function?","authors":"Necattin Fırat ,&nbsp;Alper Karacan ,&nbsp;Emrah Akın ,&nbsp;Fatih Altıntoprak ,&nbsp;Fehmi Çelebi ,&nbsp;Salih Salihi ,&nbsp;Enes M. Kocatürk ,&nbsp;İbrahim F. Küçük ,&nbsp;Hamad Dheir","doi":"10.1016/j.transproceed.2025.07.003","DOIUrl":"10.1016/j.transproceed.2025.07.003","url":null,"abstract":"<div><h3>Objective</h3><div>Vascular anatomical variations in the graft are evaluated regarding the number of arteries, early branching, and venous drainage. The aim of this study was to compare the outcomes of patients who underwent double renal artery anastomosis and single renal artery anastomosis in LDKT.</div></div><div><h3>Methods</h3><div>Between April 2019 and December 2023, LDKT cases were retrospectively evaluated in our center. A control group was formed from patients who underwent single renal artery anastomosis with similar characteristics to those who underwent double renal artery anastomosis. Demographic characteristics, graft function tests, routine blood and urine tests, postoperative artery resistivity index (ARI) and pulsatile index (PI) values, post-transplant complications, length of hospitalization, and control parameters at the last follow-up were evaluated.</div></div><div><h3>Results</h3><div>174 living donor kidney transplants were performed during the defined period. The study group consisted of 20 patients (DRA group) who underwent double renal artery anastomosis, and the control group (SRA group) consisted of 33 patients who underwent single renal artery anastomosis. There was no significant difference between the demographic characteristics of the donors and recipients (<em>P</em> &gt; .05). Postop and current ARI and PI values were also similar between the 2 groups (<em>P</em> &gt; .05). However, the albumin/creatinine ratio in spot urine was significantly higher in DRA group compared to SRA group (<em>P</em> = .039).</div></div><div><h3>Conclusion</h3><div>Multiple vessel anastomoses are inevitably performed because of the variations seen in renal arteries. Even if the artery diameter is small, with good surgical technique, similar results can be achieved to anastomoses in single artery grafts.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Pages 1744-1747"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effectiveness, Safety, and Patient Satisfaction of Artificial Intelligence-Based Patient Education and Counseling for Both Recipients and Donors in the Preoperative and Postoperative Phases of Organ Transplantation","authors":"Veysel Umman ,&nbsp;Busra Tosun ,&nbsp;Abdulkerim Uygur ,&nbsp;Sukru Emre","doi":"10.1016/j.transproceed.2025.07.001","DOIUrl":"10.1016/j.transproceed.2025.07.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Effective patient education is critical in organ transplantation, particularly for living donor groups, where informed decision-making impacts both donors and recipients. AI-driven solutions, such as OpenAI's ChatGPT, can enhance education by providing real-time responses. This study assessed the effectiveness, safety, and satisfaction of an AI-supported patient education system integrated with WhatsApp and a Customer Relationship Management (CRM) system.</div></div><div><h3>Methods</h3><div>A prospective observational study was conducted at our transplant center between October 1, 2023, and July 31, 2024. Eligible participants included adults (18-65 years) who were either recipients or living donor candidates for kidney and liver transplantation. AI-generated responses were retrospectively evaluated by transplant physicians for accuracy and safety using a 5-point Likert scale. Patient satisfaction was assessed using the validated Turkish Short Assessment of Patient Satisfaction (SAPS) form.</div></div><div><h3>Results</h3><div>A total of 196 patients submitted 1281 questions, categorized into nine thematic groups. The most common inquiries pertained to post-transplant social life and work resumption (25.2%). AI responses demonstrated high safety (92% scoring ≥4) and accuracy (80% scoring ≥4). The highest accuracy was for surgical technique-related questions (4.7/5), while general questions had the lowest (4.2/5). Patient satisfaction was overwhelmingly positive, with 99.5% expressing satisfaction.</div></div><div><h3>Conclusion</h3><div>The AI-supported system provided accurate and safe preoperative and postoperative education for transplant patients, demonstrating high satisfaction. AI integration into clinical workflows presents a promising advancement, though challenges related to accuracy and ethics remain. Future research should explore AI’s role in image recognition and triage to optimize transplant patient care.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Pages 1832-1839"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Suboptimal Graft Function at 1 Month Post-Transplantation on Long-Term Outcomes in Living Donor Kidney Transplant Recipients: A Retrospective Cohort Study","authors":"Young Jun Park ,&nbsp;Sang Seob Yun ,&nbsp;Sun Cheol Park ,&nbsp;Eun Ju Jang ,&nbsp;Jeong Kye Hwang ,&nbsp;Mi Hyeong Kim ,&nbsp;Hyung Jin Cho ,&nbsp;Kang Woong Jun ,&nbsp;Ji Il Kim ,&nbsp;Sangkyun Mok","doi":"10.1016/j.transproceed.2025.09.008","DOIUrl":"10.1016/j.transproceed.2025.09.008","url":null,"abstract":"<div><h3>Introduction</h3><div>While most recipients of living donor kidney transplantation experience rapid recovery of renal function, a subset shows suboptimal recovery of graft function despite sufficient postoperative time. The long-term implications of this suboptimal recovery of graft function remain unclear. This study aimed to assess the long-term outcomes of patients with suboptimal renal function 1-month post-transplantation.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 411 living donor kidney transplant recipients at a single center from January 2006 to February 2014, with a mean follow-up of 11.3 years. Patients were categorized into 2 groups based on 1-month post-transplant serum creatinine: suboptimal (&gt;1.2 mg/dL) and standard (≤1.2 mg/dL). Clinical, immunological, and donor-recipient variables were compared. Primary outcomes included acute rejection, graft survival, and patient survival. Kaplan-Meier and log-rank analysis were used for outcome assessment.</div></div><div><h3>Results</h3><div>The suboptimal group comprised 84 patients (20.4%). They were younger, predominantly male, had higher body mass index, and more frequently received smaller grafts from older donors with lower donor-to-recipient weight ratios. Acute rejection within 1 month occurred more frequently in this group (8.3% vs. 1.8%, <em>P = .</em>007). Despite these differences, no significant differences were observed in graft failure, mortality, infections, or malignancies, and long-term graft or patient survival did not differ significantly between the suboptimal and standard groups.</div></div><div><h3>Conclusions</h3><div>Suboptimal graft function at 1-month post-transplantation is associated with increased acute rejection but does not independently predict inferior long-term graft or patient survival. These findings suggest that long-term outcomes can be preserved despite suboptimal functional recovery.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 8","pages":"Pages 1502-1507"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of HLA Alleles on the Severity of COVID-19 in Kidney Transplant Patientss","authors":"Hayriye Senturk Ciftci ,&nbsp;Erol Demir ,&nbsp;Demet Kivanc ,&nbsp;Huseyin Bakkaloglu ,&nbsp;Ayse Erol Bozkurt ,&nbsp;Cigdem Kekik Cinar ,&nbsp;Meltem Savran Karadeniz ,&nbsp;Tzevat Tefik ,&nbsp;Ayse Serra Artan ,&nbsp;Yeliz Ogret ,&nbsp;Mediha Suleymanoglu ,&nbsp;Nurana Garayeva ,&nbsp;Aydın Turkmen ,&nbsp;Ismet Nane ,&nbsp;Ali Emin Aydin ,&nbsp;Fatma Savran Oguz","doi":"10.1016/j.transproceed.2025.06.020","DOIUrl":"10.1016/j.transproceed.2025.06.020","url":null,"abstract":"<div><h3>Background</h3><div>Human Leukocyte Antigen (HLA) genes play a crucial role in immune response against infectious disease. In this study, we aimed to investigate the frequency of HLA alleles in kidney transplant patients diagnosed with COVID-19 and explore potential associations with disease severity.</div></div><div><h3>Material and methods</h3><div>Kidney transplant patients who were diagnosed with COVID-19 and followed up at the Istanbul Medical Faculty Hospital kidney transplant clinic between March 2020 and January 2023 were included in this study. All patients were genotyped for HLA loci (HLA-A,-B,-DRB1) at low resolution using the Luminex method. Patients were classified as mild, moderate, and severe according to COVID-19 severity.</div></div><div><h3>Results</h3><div>In a study of 332 kidney transplant patients, 52 developed severe COVID-19, with 24 deaths. Severe cases were older and had higher rates of hospitalization, Intensive Care Unit (ICU) admissions, acute kidney injury, and mortality (all <em>P &lt; .</em>001). The HLA-B*38 and HLA-DRB1*11 alleles were more common in severe cases (<em>P = .</em>045 and <em>P = .</em>005). Among those who died, cardiovascular disease, longer hospital stays, and ICU admissions were more frequent (all <em>P &lt; .</em>001). <em>The HLA-B*35 allele was higher in the deceased (P = .021), while the HLA-DRB1*03 allele was absent in those who died but present in 8.3% of survivors (P = .042).</em></div></div><div><h3>Conclusion</h3><div><em>The association with HLA was examined for susceptibility with COVID-19 infection in patients who underwent kidney transplantation: HLA-B*38 and HLA-DRB1*11 were found to be more common in patients with SARS-CoV-2 infections</em>.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 8","pages":"Pages 1420-1428"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological Rejection in a Heterotopic Rat Liver Transplant Model","authors":"Camryn Thompson ,&nbsp;Bret Verhoven ,&nbsp;Min Zhang ,&nbsp;Weifeng Zeng ,&nbsp;Isaac Alderete ,&nbsp;Ahmed Hassan ,&nbsp;Peter Chlebeck ,&nbsp;Kristina Matkowskyj ,&nbsp;Heather Jennings ,&nbsp;Andrew S. Barbas ,&nbsp;David Al-Adra","doi":"10.1016/j.transproceed.2025.06.024","DOIUrl":"10.1016/j.transproceed.2025.06.024","url":null,"abstract":"<div><h3>Background</h3><div>Rat liver transplant (LT) studies typically utilize the technically demanding orthotopic transplant model, which is stressful for the recipient animal. Therefore, we developed a less technically challenging heterotopic LT model that reduces post-operative animal stress and used this model to characterize rejection in 2 genetically mismatched rat pairs.</div></div><div><h3>Methods</h3><div>Syngeneic transplants were performed with Lewis rats as liver donors and recipients. Allogeneic transplants utilized Dark Agouti donors and Lewis recipients or Lewis donors and Brown Norway recipients. The whole donor liver was transplanted in a heterotopic position in the left side of the abdominal cavity after a left nephrectomy. At pre-defined endpoints, liver grafts were excised and examined using the Banff rejection activity index (RAI).</div></div><div><h3>Results</h3><div>In 9 sequential syngeneic transplants there were 2 technical errors that resulted in deaths. The Dark Agouti-Lewis cohort of 7 allogeneic transplants had 1 technical error resulting in death and 2 thrombosis-related graft failures. The Lewis-Brown Norway cohort of 10 transplants had 2 technical errors resulting in death and 3 thrombosis-related graft failures. All technical errors and thrombosis occurred early in each series. Syngeneic transplants demonstrated no rejection (mean RAI of 0). Allogeneic transplants demonstrated mild rejection by post-operative day 3 (mean RAI of 4.5) and severe rejection by post-operative day 8 (mean RAI of 9).</div></div><div><h3>Conclusion</h3><div>Heterotopic LT is a viable rejection model that minimizes surgical complexity and animal distress. Allogeneic heterotopic LT demonstrated severe rejection in a timeline similar to the commonly used orthotopic model.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 8","pages":"Pages 1668-1673"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplantation with Nonstandard Donor Hearts: Single Center Experience in Central China","authors":"Qianhai Huang ,&nbsp;Junlong Hu ,&nbsp;Zhigao Chen ,&nbsp;Jizhong Xuan ,&nbsp;Jianchao Li ,&nbsp;Xiaoliang Qian ,&nbsp;Liang Zhao ,&nbsp;Qianjin Liu ,&nbsp;Zhaoyun Cheng","doi":"10.1016/j.transproceed.2025.08.025","DOIUrl":"10.1016/j.transproceed.2025.08.025","url":null,"abstract":"<div><h3>Background</h3><div>Recently, marginal donor hearts have been applied to patients with end-stage heart failure due to rising waiting list mortality and increasing demand for donors. However, the principles of risk prevention and the usage of marginal donor hearts have yet to be clearly defined.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed to investigate the outcomes of patients undergoing heart transplantation at our center between October 2019 and March 2024. Forty-four patients were enrolled and divided into the marginal donor heart group (n = 30) and the conventional donor heart group (n = 14) according to the classification criteria. The clinical data between the 2 groups were compared and analyzed.</div></div><div><h3>Results</h3><div>There were no statistically significant differences in the postoperative length of hospitalization, ICU stay, left ventricular ejection fraction, or serum biochemical indicators between the 2 groups. Five patients died during the 3-month follow-up period. Notably, 1- and 3- month postoperative follow-up showed no significant differences in left ventricular ejection fraction, serum biochemical indicators, and mortality between the 2 groups</div></div><div><h3>Conclusion</h3><div>The application of marginal donor hearts can partially alleviate the shortage of donor heart resources. It did not significantly affect patients’ short-term survival or recovery.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 8","pages":"Pages 1387-1394"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Native Right Nephrectomy and Extraperitoneal Pediatric Kidney Transplantation Using the Same Incision for Both Surgeries","authors":"Gaetano Ciancio ,&nbsp;Marina M. Tabbara ,&nbsp;Jeffrey J. Gaynor ,&nbsp;Javier Gonzalez ,&nbsp;Mahmoud Morsi ,&nbsp;Angel Alvarez ,&nbsp;Marissa Defreitas ,&nbsp;Francesco Angioli ,&nbsp;Jayanthi Chandar","doi":"10.1016/j.transproceed.2025.07.032","DOIUrl":"10.1016/j.transproceed.2025.07.032","url":null,"abstract":"<div><h3>Background</h3><div>Kidney transplantation is the best option for pediatric patients with end-stage kidney disease but remains challenging due to donor-recipient size mismatch. The intraperitoneal approach is associated with high morbidity, while the extraperitoneal approach is safer and more feasible. The latter approach often requires performing a native kidney nephrectomy to create sufficient space for graft placement. Clinical outcomes following simultaneous native right nephrectomy and extraperitoneal kidney transplantation through the same incision in pediatric recipients were assessed.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed all pediatric patients (age ≤18yr) at our center during 2017-2023 who received a simultaneous right native nephrectomy and open extraperitoneal kidney transplant through the same incision.</div></div><div><h3>Results</h3><div>Among 125 pediatric patients who received an extraperitoneal kidney transplant, 7 patients underwent a right native nephrectomy through the same incision at the time of kidney transplant. Median age-at-transplant was 4yr (range: 3-10yr); all patients were male. Median recipient weight was 16.5kg (range: 11.9-29.7kg). Median donor age was 26yr (range: 13-46yr). Three were deceased donors after brain death; 4 were living related donors. Median warm and cold ischemia times were 30min (range: 24-42min) and 171min (range: 26-1166min), respectively. Median estimated blood loss was 15ml (range: 5-50ml). There were no cases of delayed graft function. Median creatinine at 1, 3, 6, and 12 months' post-transplant was 0.5 (range: 0.3-0.8), 0.4 (range: 0.4-0.8), 0.5 (range: 0.4-0.7), and 0.6 (range: 0.5-0.9) mg/dL, respectively, with no reported post-operative vascular or urological complications.</div></div><div><h3>Conclusion</h3><div>The extraperitoneal surgical approach of performing simultaneous right nephrectomy and kidney transplantation using the same incision was safe and feasible without postoperative complications, avoiding 2-step procedures or 2 incisions.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 8","pages":"Pages 1404-1410"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of Personalized Conditioning Regimens in Relapsed/Refractory Acute Myeloid Leukemia Receiving Allogeneic Hematopoietic Stem Cell Transplantation","authors":"Shuangzhu Liu ,&nbsp;Biqi Zhou ,&nbsp;Chongsheng Qian,&nbsp;Zheng Li,&nbsp;Yanjun Wu,&nbsp;Zhen Yao,&nbsp;Mingzhu Xu,&nbsp;Sheng-Li Xue","doi":"10.1016/j.transproceed.2025.08.014","DOIUrl":"10.1016/j.transproceed.2025.08.014","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of personalized conditioning regimens in allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the treatment of relapsed/ refractory acute myeloid leukemia (R/R AML).</div></div><div><h3>Methods</h3><div>A retrospective analysis of the clinical data of 14 R/R AML patients who underwent allo-HSCT with a personalized conditioning regimen was conducted.</div></div><div><h3>Results</h3><div>Among the 14 patients, there were 8 males and 6 females with a median age of 34.5 years (range 14-56). One patient received a transplant from a fully matched related donor, 2 from unrelated donors, and 12 from haploidentical donors. Prior to transplantation, all patients had a myeloblast percentage greater than 5% before transplantation, with a median myeloblast of 8.5 (6-88)%. Thirteen patients (92.86%) achieved morphologic leukemia-free state (MLFS) after conditioning. All patients achieved successful engraftment and hematopoietic recovery. The median time to neutrophil engraftment was 12 days (range 10-14), and the median time to platelet engraftment was 21.5 days (range 17-29). There was no obvious hepatorenal toxicity during the conditioning, and no mucositis more than grade 2 according to CTCAE 5.0 [<span><span>1</span></span>]. Bone marrow biopsies at +30 days post-transplant indicated remission in all cases. Two patients relapsed at 2 and 3 months post-transplant, with 2 dying after relapse. Additionally, 2 patients had CMV infections; 1 became negative after treatment, while the other remained positive and later died due to severe infection. As of the last follow-up, 11 out of 14 patients were alive (with marrow morphology and MRD Continuously negative).</div></div><div><h3>Conclusion</h3><div>Allo-HSCT with a personalized conditioning regimen can be considered a treatment option for patients with R/R AML.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 8","pages":"Pages 1581-1588"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Mineral Bone Disease Profile in Kidney Transplant Recipients – A 9-Year Retrospective Cohort Study at a Tertiary Center","authors":"Jun Min Em ,&nbsp;Maisarah Jalalonmuhali ,&nbsp;Guo Jian Leon ,&nbsp;Nur Raziana Rozi ,&nbsp;Yee Wan Lee ,&nbsp;Soo Kun Lim","doi":"10.1016/j.transproceed.2025.08.024","DOIUrl":"10.1016/j.transproceed.2025.08.024","url":null,"abstract":"<div><h3>Background</h3><div>The progression of chronic kidney disease (CKD) into end-stage kidney disease and the eventual kidney transplantation is linked to substantial changes in bone mineral metabolism, predisposing to bone-related complications, including osteoporosis and fractures. Understanding the bone profile in kidney transplant recipients could improve post-transplant care and long-term outcomes.</div></div><div><h3>Methods</h3><div>This retrospective study at the University Malaya Medical Centre (UMMC) involved all kidney transplant recipients from January 2015 to December 2023. Patients without baseline serum intact parathyroid hormone levels or who had graft failure within 1 year were excluded. All baseline characteristics, medications, and pre- and post-transplant bone mineral profiles were collected from electronic medical records (EMRs) and analyzed using Statistical Package for the Social Sciences version 29.0.2.</div></div><div><h3>Results</h3><div>A total of 179 patients were included, with a mean age of 40.6 ± 11.0 years old (57% men). The median dialysis vintage was 18 (interquartile range [IQR] = 36), with 19% undergoing pre-emptive transplants. Before the transplant, 57% of the patients received calcium carbonate, 51.4% were on vitamin D receptor analogues (VDRAs), 26.3% were on sevelamer, 5.6% were on cinacalcet, 2.2% were on lanthanum, and 0.6% were on sucroferric oxyhydroxide. All patients received induction methylprednisolone during the transplant. At 1 year post-transplant, 90% of the patients remained on prednisolone at a median dose of 5.0 mg. Parathyroidectomy was performed on two patients (1.1%) before transplant and another two (1.1%) after transplant. No patient had a fracture post-transplantation during the study period. Biochemically, mean serum intact parathyroid hormone (iPTH), calcium, phosphate, and hemoglobin were significantly improved from pre-transplant to 2 years post-transplant (<em>P</em> &lt; .001), with serum iPTH and calcium showing improvement as early as 3 months and maintained thereafter. Both serum phosphate and hemoglobin levels continuously showed improvement up to 2 years post-transplant (<em>P</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>Our study showed significant improvements in biochemical bone profile and hemoglobin levels as early as 3 months post-transplant, which had continued to improve or maintain for up to 2 years post-transplant.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 8","pages":"Pages 1487-1493"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-for-Size Graft in Cadaveric Liver Transplantation: Application of BSA (Body Surface Area) for Prompt Evaluation","authors":"Yasuhiro Fujimoto,&nbsp;Norihiro Goshima,&nbsp;Yuki Masano,&nbsp;Nobuhiko Kurata,&nbsp;Yasuhiro Ogura","doi":"10.1016/j.transproceed.2025.03.024","DOIUrl":"10.1016/j.transproceed.2025.03.024","url":null,"abstract":"<div><h3>Introduction</h3><div>In recent years, with the increase in the number of brain-dead donors in Japan, brain-dead liver transplantation has been on the rise. In partial living donor liver transplantation, which accounts for the majority of liver transplants in Japan, small-for-size graft has been a problem in adult recipients, whereas large-for-size graft has not been a matter of debate. We experienced a case in which a large-for-size graft resulted in difficulty when closing the wound. With the increase in brain death transplantation, the exclusion of large-for-size grafts becomes an issue when selecting grafts.</div></div><div><h3>Methods</h3><div>Retrospective chart review. At Nagoya University, 80 brain-dead liver transplants were performed between Feb. 2005 and Dec. 2023. Comparative evaluation of BSA (body surface area) and was performed on 72 patients, excluding 8 split liver transplants, based on the height and weight of the donor and recipient at the time of transplantation. The state of wound closure was also ascertained from the surgical records.</div></div><div><h3>Results</h3><div>Seven cases out of 72 were considered “large-for-size” regarding BSA. Among them, 1 “large-for-size” patient had difficulty in closing the abdomen during the surgical procedure.</div></div><div><h3>Conclusions</h3><div>Prompt screening for matching graft size and donor body size may be possible with BSA. The algorithm allows for rapid and efficient donor-recipient matching while reducing the reliance on advanced imaging in most cases.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 8","pages":"Pages 1565-1567"},"PeriodicalIF":0.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}