Transplantation proceedings最新文献_第10页

Corrigendum to “Cytochrome b5 Interacts With Cytochrome C and Inhibits Hepatocyte Apoptosis in Brain-dead Rabbit Donors” [Transplantation Proceedings, 51/6 2019: 2108-2115] “细胞色素b5与细胞色素C相互作用抑制脑死亡兔供体肝细胞凋亡”[中国移植杂志，2019,51/6:2108-2115]。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-12-01 DOI: 10.1016/j.transproceed.2025.05.005

Yan Xiong , Lin Fan , Qiang Tu , Guizhu Peng , Yanfeng Wang , Qifa Ye

引用次数: 0

Differential Effect of Two Transplantation Methods of Adipose-derived Mesenchymal Stem Cells on Hearing Improvement in Simulated Aging Rats 脂肪源性间充质干细胞两种移植方法对模拟衰老大鼠听力改善的差异影响。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-12-01 DOI: 10.1016/j.transproceed.2025.10.003

Jia Liu , Xiuying Wang , Na Li , Danna Chen , Dawei Yang

Background

Presbycusis is an age-related condition characterized by symmetrical bilateral hearing loss that progresses to total deafness in severe cases. Mesenchymal stem cells demonstrate strong therapeutic and regenerative potential, making it worthwhile to explore optimal transplantation pathways for improving age-related hearing loss.

Methods

Rats were injected with D-galactose to establish an animal model simulating aging. Adipose-derived stem cells were injected intravenously and into the auditory cortex. The hearing of rats was assessed indirectly through the establishment of an acoustic fear conditioned reflex and directly evaluated by the auditory brainstem response. Gabaergic neurons in the auditory cortex were detected using indirect immunofluorescence, and apoptosis was detected using the terminal uridine nick-end labeling method.

Results

In comparison with the control group, rats in the model B group exhibited a poor association between sound and electrical stimulation. Similar results were observed in the group injected intravenously with adipose-derived stem cells (group C). However, acoustical fear conditioning was more effectively established in the auditory cortex injection group (group D). Auditory brainstem response analysis revealed a significantly lower hearing threshold in group D compared with group B, indicating a more pronounced hearing recovery in rats receiving auditory cortex injections, whereas intravenous stem cell injection had no discernible effect. In group D, there was a substantial increase in the number of GABAergic neurons, a slight decrease in apoptotic cells, and a significant decrease in apoptotic GABAergic neurons.

Conclusions

The injection of adipose-derived stem cells into the auditory cortex is able to ameliorate deafness in rats with simulated aging, which may be effected mainly by increasing the number of GABAergic neurons.

背景：老年性耳聋是一种与年龄相关的疾病，其特征是对称性双侧听力丧失，严重者可发展为全聋。间充质干细胞显示出强大的治疗和再生潜力，因此值得探索改善年龄相关性听力损失的最佳移植途径。方法：给大鼠注射d -半乳糖，建立模拟衰老动物模型。将脂肪来源的干细胞静脉注射到听觉皮层。通过建立声恐惧条件反射间接评价大鼠的听力，通过听觉脑干反应直接评价大鼠的听力。用间接免疫荧光法检测听觉皮层gabaergy神经元，用末端尿苷镍端标记法检测细胞凋亡。结果：与对照组相比，B模型组大鼠声电刺激相关性较差。在静脉注射脂肪来源干细胞组（C组）中观察到类似的结果。然而，听觉皮层注射组（D组）更有效地建立了听觉恐惧条件反射。听觉脑干反应分析显示，与B组相比，D组的听力阈值明显降低，这表明接受听觉皮层注射的大鼠听力恢复更为明显，而静脉注射干细胞则没有明显的效果。D组gabaergy神经元数量显著增加，凋亡细胞略有减少，凋亡gabaergy神经元数量明显减少。结论：将脂肪来源的干细胞注入听觉皮层能够改善模拟衰老大鼠的耳聋，其主要作用可能是增加gaba能神经元的数量。

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引用次数: 0

Challenges in Management of BK Virus Infections in HIV-Infected Renal Transplant Recipients hiv感染肾移植受者BK病毒感染管理的挑战

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-12-01 DOI: 10.1016/j.transproceed.2025.10.017

Dante A. Puntiel, Jayalakshmi N. Alagar, Julienne Jeong, Dianly C. Centeno, Ryan A. Quan, Brooke Stanicki, Ibrahim Y. Khalil, Konstantinos A. Zorbas, Sunil S. Karhadkar

Background

BK virus (BKV) poses a significant threat to kidney transplantation as it can lead to severe complications, including BK virus nephropathy (BKVN). Many transplant recipients harbor latent BKV, which can reactivate under immunosuppression, leading to viruria, viremia, and potential graft loss. The management of BKVN in human immunodeficiency virus (HIV)-positive patients is especially complex owing to the dual challenge of balancing immunosuppressive therapy and antiretroviral treatment, compounded by potential drug interactions. This study aimed to investigate the incidence, risk factors, and outcomes of BKVN in HIV-positive kidney transplant recipients, comparing these findings to findings in HIV-negative recipients.

Methods

The United Network for Organ Sharing database was used to identify kidney transplant recipients between August 2009 and February 2022, excluding those age <18 years, with prior transplants, or with unknown HIV status. Parametric and nonparametric tests were used to assess risk factors for BKVN in HIV-positive individuals.

Results

Among 1909 HIV-positive kidney transplant recipients, 15 (0.8%) experienced graft loss due to BKVN, compared to 558 of 168,836 (0.3%) HIV-negative recipients. HIV-positive individuals had a higher risk of BKVN-related graft loss (P < .001). In the HIV-positive group, delayed graft function (DGF), greater HLA mismatch, older donor age, older recipient age, and a history of diabetes were significant risk factors for BKVN. The HIV-positive BKVN group had shorter graft survival compared to their HIV-negative counterparts (P = .044).

Conclusion

This study confirms that HIV-positive individuals are at greater risk of graft loss due to BKVN, with risk factors including DGF, greater HLA mismatch, older donor and recipient age, and a history of diabetes.

背景：BK病毒（BKV）对肾移植造成重大威胁，因为它可导致严重并发症，包括BK病毒肾病（BKVN）。许多移植受者携带潜伏的BKV，它可以在免疫抑制下重新激活，导致病毒血症、病毒血症和潜在的移植物损失。人类免疫缺陷病毒（HIV）阳性患者BKVN的管理特别复杂，因为平衡免疫抑制治疗和抗逆转录病毒治疗的双重挑战，加上潜在的药物相互作用。本研究旨在调查hiv阳性肾移植受者BKVN的发生率、危险因素和结局，并将这些结果与hiv阴性肾移植受者的结果进行比较。方法：使用联合器官共享网络数据库识别2009年8月至2022年2月期间的肾移植受者，不包括年龄。结果：在1909名hiv阳性肾移植受者中，15名（0.8%）因BKVN发生移植损失，而168,836名hiv阴性受者中有558名（0.3%）发生移植损失。hiv阳性个体发生bkvn相关移植物丢失的风险较高（P < 0.001）。在hiv阳性组中，移植功能延迟（DGF）、HLA不匹配、供体年龄较大、受体年龄较大和糖尿病史是BKVN的重要危险因素。与hiv阴性组相比，hiv阳性BKVN组的移植物存活时间较短（P = 0.044）。结论：本研究证实hiv阳性个体由于BKVN导致移植物损失的风险更大，其危险因素包括DGF、HLA错配更大、供体和受体年龄更大以及糖尿病史。

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引用次数: 0

Outcomes and Indications of Early vs Late Allograft Nephrectomy: A Retrospective Analysis From a Tertiary Center 早期和晚期同种异体肾切除术的结果和适应症：来自三级中心的回顾性分析。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-12-01 DOI: 10.1016/j.transproceed.2025.10.005

Ricardo Mendonça Rodrigues , Lucas Villard , Alberto Costa Silva , Teresa Pina Vaz , João Oliveira , Tiago Antunes-Lopes , Carlos Silva , João Silva

Background

Renal allograft nephrectomy remains a complex and high-risk procedure, often performed following graft failure. While its indications and outcomes vary, the optimal timing for nephrectomy remains controversial.

Objective

To compare early (≤60 days post-transplant) vs late (>60 days) allograft nephrectomies in terms of clinical indications, surgical outcomes, complications, and mortality in a tertiary care center.

Methods

We conducted a retrospective observational study including all patients undergoing renal allograft nephrectomy between January 2010 and July 2024. Patients were stratified into early and late nephrectomy groups. Data were analyzed regarding demographic characteristics, indications, urgency, surgical technique, complications (Clavien-Dindo classification), transfusion requirements, length of stay, and follow-up outcomes.

Results

Among 109 nephrectomies (11.0% of 985 transplants), 55 were early and 54 were late. Early nephrectomies were more frequently urgent (87.3% vs 29.6%, P < .001) and associated with higher transfusion rates, longer hospitalization (median 16 vs 10 days, P = .011), and more complications (22.8% vs 12.7%, P = .164). Major indications differed: vascular thrombosis and hemorrhagic shock were predominant in early nephrectomies, while chronic rejection and infection prevailed in late cases. Urgent nephrectomies, irrespective of timing, were linked to significantly higher complication rates (P < .001). No intraoperative deaths occurred, but all 3 postoperative deaths were in the early group.

Conclusions

Early allograft nephrectomies, typically performed for urgent complications, are associated with increased morbidity, transfusion needs, and hospital stay. Late nephrectomies, often elective, have been associated with better postoperative outcomes. These findings underscore the need for standardized guidelines and prospective studies to optimize the management of failed renal grafts.

背景：同种异体肾移植切除术仍然是一个复杂和高风险的手术，通常在移植失败后进行。虽然其适应症和结果各不相同，但最佳的肾切除术时间仍然存在争议。目的：比较早期（移植后≤60天）和晚期（移植后≤60天）同种异体肾切除术在临床适应证、手术结果、并发症和死亡率方面的差异。方法：我们对2010年1月至2024年7月接受同种异体肾切除术的所有患者进行回顾性观察研究。患者分为早期和晚期肾切除术组。数据分析包括人口统计学特征、适应症、紧急情况、手术技术、并发症（Clavien-Dindo分类）、输血需求、住院时间和随访结果。结果：109例肾切除术中，早期55例，晚期54例，占985例移植的11.0%。早期肾切除术更为急症（87.3% vs 29.6%, P < 0.001），并与较高的输血率、较长的住院时间（中位16天vs 10天，P = 0.011）和更多的并发症（22.8% vs 12.7%, P = 0.164）相关。主要适应症不同：早期肾切除术以血管血栓形成和失血性休克为主，而晚期以慢性排斥反应和感染为主。无论何时进行紧急肾切除术，其并发症发生率均显著升高（P < 0.001）。术中无死亡发生，术后3例死亡均发生在早期组。结论：早期同种异体移植肾切除术，通常用于紧急并发症，与增加的发病率，输血需求和住院时间有关。晚期肾切除术，通常是选择性的，与较好的术后预后相关。这些发现强调需要标准化的指南和前瞻性研究来优化肾移植失败的管理。

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引用次数: 0

The 15th Turkish Transplantation Centers Coordination Association (TTCCA) MeetingGaziantep, TurkeyOctober 17-20, 2024Guest Editor: Sukru EmreCo-Guest Editor: Kamil Yalcin Polat 第15届土耳其移植中心协调协会（TTCCA）会议将于2024年10月17日至20日在土耳其加济安泰普举行

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-11-01 DOI: 10.1016/S0041-1345(25)00496-8

引用次数: 0

Effectiveness of Variceal Band Application in Preventing Bile Leakage Associated With Trans-Cystic Feeding Catheter in Living-Donor Liver Transplantation 静脉曲张带在活体肝移植中预防经囊性喂养管胆漏中的应用效果。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.06.014

Adem Tuncer , Canan Dilay Dirican , Emrah Sahin , Veysel Ersan , Feyza Sönmez Topcu , Hasret Ayyıldız Civan , Bülent Unal , Abuzer Dirican

Objective

Despite advancements in surgical techniques, biliary complications remain a significant concern in liver transplantation. This study evaluated the effectiveness of applying a variceal band to the cystic duct stump in preventing bile leakage in patients with a trans-cystic feeding catheter.

Methods

The medical records of 328 liver transplant recipients between April 2022 and June 2024 were retrospectively reviewed. A total of 170 patients with trans-cystic external catheters were included in the study. Of these, 116 patients underwent variceal band application to the cystic duct stump, while 54 did not. The 2 groups were compared regarding demographic characteristics, graft weight, number of bile ducts, presence of bile leakage, and MELD scores.

Results

Among the 170 patients who underwent living-donor liver transplantation (LDLT), 58.8% were male, and 41.2% were female. Graft weight was significantly higher in the group with the variceal band application (p < .05). Bile leakage from the cystic duct stump occurred in 2 patients in the group without variceal banding, whereas no bile leakage was observed in the variceal band group. These 2 cases were successfully treated with percutaneous catheter placement under radiologic guidance.

Conclusion

The variceal band application is an effective and promising method for reducing bile leakage in LDLT patients utilizing a trans-cystic feeding catheter. However, multicenter studies with larger patient cohorts are necessary to more definitively assess the safety and efficacy of this technique.

目的：尽管手术技术进步，胆道并发症仍然是肝移植的一个重要问题。本研究评估了在胆囊管残端应用静脉曲张带防止经囊性喂养导管患者胆漏的有效性。方法：回顾性分析2022年4月至2024年6月328例肝移植受者的病历。本研究共纳入170例经囊外置管患者。其中，116例患者接受了囊管残端静脉曲张绑扎术，54例未行。比较两组患者的人口学特征、移植物重量、胆管数量、胆漏情况和MELD评分。结果：170例活体肝移植患者中，男性占58.8%，女性占41.2%。静脉曲张带组移植物重量显著高于静脉曲张带组（p < 0.05）。无静脉曲张束带组2例患者出现胆囊管残端胆漏，而有静脉曲张束带组未见胆漏。2例均在放射学指导下经皮置管治疗成功。结论：静脉曲张带是减少LDLT患者经囊性喂食管胆漏的有效方法。然而，为了更明确地评估该技术的安全性和有效性，需要更多患者队列的多中心研究。

{"title":"Effectiveness of Variceal Band Application in Preventing Bile Leakage Associated With Trans-Cystic Feeding Catheter in Living-Donor Liver Transplantation","authors":"Adem Tuncer , Canan Dilay Dirican , Emrah Sahin , Veysel Ersan , Feyza Sönmez Topcu , Hasret Ayyıldız Civan , Bülent Unal , Abuzer Dirican","doi":"10.1016/j.transproceed.2025.06.014","DOIUrl":"10.1016/j.transproceed.2025.06.014","url":null,"abstract":"<div><h3>Objective</h3><div>Despite advancements in surgical techniques, biliary complications remain a significant concern in liver transplantation. This study evaluated the effectiveness of applying a variceal band to the cystic duct stump in preventing bile leakage in patients with a trans-cystic feeding catheter.</div></div><div><h3>Methods</h3><div>The medical records of 328 liver transplant recipients between April 2022 and June 2024 were retrospectively reviewed. A total of 170 patients with trans-cystic external catheters were included in the study. Of these, 116 patients underwent variceal band application to the cystic duct stump, while 54 did not. The 2 groups were compared regarding demographic characteristics, graft weight, number of bile ducts, presence of bile leakage, and MELD scores.</div></div><div><h3>Results</h3><div>Among the 170 patients who underwent living-donor liver transplantation (LDLT), 58.8% were male, and 41.2% were female. Graft weight was significantly higher in the group with the variceal band application (<em>p</em> < .05). Bile leakage from the cystic duct stump occurred in 2 patients in the group without variceal banding, whereas no bile leakage was observed in the variceal band group. These 2 cases were successfully treated with percutaneous catheter placement under radiologic guidance.</div></div><div><h3>Conclusion</h3><div>The variceal band application is an effective and promising method for reducing bile leakage in LDLT patients utilizing a trans-cystic feeding catheter. However, multicenter studies with larger patient cohorts are necessary to more definitively assess the safety and efficacy of this technique.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Pages 1777-1780"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring CD3(+) T Cells in Kidney Transplantation and Immunosuppression Adequacy 肾移植中CD3(+) T细胞监测与免疫抑制充分性。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.06.016

Kemal Eyvaz MD, FEBS, FACS, Arif Aslaner MD, FACS, Arif Ata Kiravkazli MD

Background

Monitoring CD3(+) T-cell counts in kidney transplant recipients can provide valuable insights into immunosuppressive therapy effectiveness. This study aimed to evaluate the use of CD3(+) T-cell levels as biomarkers for immunosuppression adequacy and to assess their predictive value for acute rejection post-transplantation.

Methods

A retrospective review was conducted involving 130 kidney transplant recipients who received induction therapy with antithymocyte globulin (ATG). CD3(+) T-cell percentages and absolute counts were measured using flow cytometry on postoperative day 5. Immunosuppression was maintained with tacrolimus, initiated upon clinical indicators of graft function recovery.

Results

Among monitored patients, the median CD3(+) T-cell percentage was 48%, and median absolute count was 0.14 × 10⁹/L. Acute rejection occurred in 9.9% of recipients. Higher CD3(+) T-cell values significantly correlated with acute rejection (64.0% vs 47.5%, p = .011; absolute count 0.28 vs 0.13 × 10⁹/L, p = .032). ROC analysis identified optimal predictive thresholds: 54% for CD3(+) percentage (sensitivity 85.7%, specificity 73.4%) and 0.21 × 10⁹/L for absolute count (sensitivity 85.7%, specificity 75.0%).

Conclusions

CD3(+) T-cell monitoring effectively guides individualized immunosuppressive strategies, significantly predicting acute rejection risks and optimizing graft outcomes.

背景：监测肾移植受者的CD3(+) t细胞计数可以为免疫抑制治疗的有效性提供有价值的见解。本研究旨在评估CD3(+) t细胞水平作为免疫抑制充分性的生物标志物的使用，并评估其对移植后急性排斥反应的预测价值。方法：对130例接受抗胸腺细胞球蛋白（ATG）诱导治疗的肾移植患者进行回顾性分析。术后第5天用流式细胞术检测CD3(+) t细胞百分比和绝对计数。根据移植物功能恢复的临床指标，他克莫司维持免疫抑制。结果：在监测的患者中，CD3(+) t细胞百分比中位数为48%，绝对计数中位数为0.14 × 10⁹/L。9.9%的受者发生急性排斥反应。高CD3(+) t细胞值与急性排斥反应显著相关(64.0% vs 47.5%, p = 0.011；绝对计数0.28 vs 0.13 × 10⁹/L, p = 0.032)。ROC分析确定了最佳预测阈值：CD3（+）百分比为54%（敏感性85.7%，特异性73.4%），绝对计数为0.21 × 10⁹/L（敏感性85.7%，特异性75.0%）。结论：CD3(+) t细胞监测可有效指导个体化免疫抑制策略，显著预测急性排斥风险和优化移植结果。

{"title":"Monitoring CD3(+) T Cells in Kidney Transplantation and Immunosuppression Adequacy","authors":"Kemal Eyvaz MD, FEBS, FACS, Arif Aslaner MD, FACS, Arif Ata Kiravkazli MD","doi":"10.1016/j.transproceed.2025.06.016","DOIUrl":"10.1016/j.transproceed.2025.06.016","url":null,"abstract":"<div><h3>Background</h3><div>Monitoring CD3(+) T-cell counts in kidney transplant recipients can provide valuable insights into immunosuppressive therapy effectiveness. This study aimed to evaluate the use of CD3(+) T-cell levels as biomarkers for immunosuppression adequacy and to assess their predictive value for acute rejection post-transplantation.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted involving 130 kidney transplant recipients who received induction therapy with antithymocyte globulin (ATG). CD3(+) T-cell percentages and absolute counts were measured using flow cytometry on postoperative day 5. Immunosuppression was maintained with tacrolimus, initiated upon clinical indicators of graft function recovery.</div></div><div><h3>Results</h3><div>Among monitored patients, the median CD3(+) T-cell percentage was 48%, and median absolute count was 0.14 × 10⁹/L. Acute rejection occurred in 9.9% of recipients. Higher CD3(+) T-cell values significantly correlated with acute rejection (64.0% vs 47.5%, <em>p</em> = .011; absolute count 0.28 vs 0.13 × 10⁹/L, <em>p</em> = .032). ROC analysis identified optimal predictive thresholds: 54% for CD3(+) percentage (sensitivity 85.7%, specificity 73.4%) and 0.21 × 10⁹/L for absolute count (sensitivity 85.7%, specificity 75.0%).</div></div><div><h3>Conclusions</h3><div>CD3(+) T-cell monitoring effectively guides individualized immunosuppressive strategies, significantly predicting acute rejection risks and optimizing graft outcomes.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Pages 1715-1720"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Portal Vein Variants on the Margin of Error in Graft Volume Calculation in Living Donor Right Lobe Liver Transplantation 门静脉变异对活体右肝移植移植物体积计算误差范围的影响。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.06.017

Feyza Sönmez Topcu , Veysel Ersan , Emrah Şahin , Adem Tunçer , Hasret Ayyıldız Civan , Abuzer Dirican , Bülent Ünal

Background

Selecting the appropriate graft for living donor liver transplantation requires accurate calculation of estimated graft volume.

Purpose

To investigate the error rate in graft volume calculation in the preoperative evaluation of donor liver and the contribution of donor portal vein type to the error margin.

Material and Methods

The study included 197 right lobe liver donors. Estimated graft volume calculations based on preoperative radiological images of donors were retrospectively reviewed. Demographic data of the donors and liver portal vein type were recorded. The proportional differences between the weight of the right lobe graft removed during transplantation and the estimated volume were calculated separately according to the portal vein groups. The margin of error in the estimated graft volume measurement and the effect of portal vein type were statistically evaluated.

Results

Considering all donors, estimated preoperative volume was calculated to be 6.877% higher than actual graft weight on average. Preoperative estimated graft volume was on average 5.746% higher for Type 1, 8.311% higher for Type 2, and finally 17.883% higher for Type 3 portal vein variant. It was shown that, as the portal vein anatomy in the donor becomes more complex, the negatively proportional difference in preoperative volume estimation increases.

Conclusion

Volume estimation showed a negative proportional difference for all three variants of the portal vein. Especially, the presence of a Type 3 portal vein in the liver graft may cause more errors in preoperative graft volume calculation.

背景：为活体供肝移植选择合适的移植物需要准确计算估计的移植物体积。目的：探讨供肝术前评估中移植物体积计算的错误率及供肝门静脉类型对错误率的贡献。材料与方法：197例右肝供体。基于供体术前放射影像估计移植物体积的计算被回顾性回顾。记录供体及肝门静脉类型的人口学资料。根据门静脉组分别计算移植过程中切除的右叶移植物重量与估计体积的比例差异。对估计移植物体积测量的误差范围和门静脉类型的影响进行统计评估。结果：考虑所有供体，术前估计体积比实际移植重量平均高6.877%。术前估计移植物体积1型增加5.746%，2型增加8.311%，3型增加17.883%。研究表明，随着供体门静脉解剖结构变得更加复杂，术前体积估计的负比例差异增加。结论：门静脉三种变型的体积估计呈负比例差异。尤其是肝移植物中存在3型门静脉，可能会导致术前移植物体积计算出现更多误差。

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引用次数: 0

Experiences of Potential Living Donors Who Withdrew From Liver Donor Evaluation: A Qualitative Study 潜在活体供者退出肝供者评估的经验：一项定性研究。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.08.006

Tugba Nur Oden , Tufan Gumus , Sirin Vatansever Durmus , Alper Uguz

Background

Understanding the psychological, emotional, and managerial challenges faced by potential donors is essential for the proper management of the living donor evaluation process, and appropriate solutions need to be developed for these challenges. This study aimed to explore the experiences of potential liver donors who voluntarily withdrew from the living donor evaluation process.

Methods

A phenomenological qualitative design was employed. Ten participants who had voluntarily withdrawn from the living donor evaluation process were interviewed. Three main themes were identified: (1) Experiences Related to the Evaluation Process, (2) Reasons for the Withdrawal Decision, and (3) Recommendations regarding the potential donor evaluation process.

Results

Positive experiences included adequate information sharing, emotional support, psychiatric consultations, and support from hospital staff. Negative experiences focused on prolonged waiting times, psychological and emotional barriers, systemic and organizational issues. Key reasons for withdrawal included concerns about health and surgical risks, family responsibilities, psychological unpreparedness, and organizational difficulties experienced throughout the evaluation process. Participants suggested accelerating hospital procedures, improving communication with specialists, offering accommodation during the evaluation process, and increasing public awareness about organ donation.

Conclusions

The findings emphasize the need to improve the living donor evaluation process. Prioritizing donor candidates, expediting procedures, and developing donor support programs that address physical, emotional, financial, and systemic needs may enhance the effectiveness of living donor transplantation.

背景：了解潜在捐赠者面临的心理、情感和管理方面的挑战，对于正确管理活体捐赠者评估过程至关重要，需要针对这些挑战制定适当的解决方案。本研究旨在探讨自愿退出活体供者评估过程的潜在肝供者的经历。方法：采用现象学定性设计。十位自愿退出活体捐献者评估过程的参与者接受了采访。确定了三个主要主题：(1)与评估过程相关的经验；(2)退出决定的原因；(3)关于潜在捐助者评估过程的建议。结果：积极体验包括充分的信息分享、情感支持、精神咨询和医院工作人员的支持。消极体验主要集中在等待时间过长、心理和情感障碍、系统和组织问题上。退出的主要原因包括担心健康和手术风险、家庭责任、心理准备不足以及在整个评估过程中遇到的组织困难。与会者建议加快医院程序，改善与专家的沟通，在评估过程中提供住宿，以及提高公众对器官捐赠的认识。结论：研究结果强调了改进活体供体评估过程的必要性。优先考虑供体候选人，加快程序，制定供体支持计划，解决身体，情感，经济和系统需求，可以提高活体供体移植的有效性。

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引用次数: 0

TTCCA 2024 Meeting Preface ttcca2024年会议序

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings

Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.10.002

引用次数: 0