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Outcomes and Indications of Early vs Late Allograft Nephrectomy: A Retrospective Analysis From a Tertiary Center 早期和晚期同种异体肾切除术的结果和适应症:来自三级中心的回顾性分析。
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-12-01 DOI: 10.1016/j.transproceed.2025.10.005
Ricardo Mendonça Rodrigues , Lucas Villard , Alberto Costa Silva , Teresa Pina Vaz , João Oliveira , Tiago Antunes-Lopes , Carlos Silva , João Silva

Background

Renal allograft nephrectomy remains a complex and high-risk procedure, often performed following graft failure. While its indications and outcomes vary, the optimal timing for nephrectomy remains controversial.

Objective

To compare early (≤60 days post-transplant) vs late (>60 days) allograft nephrectomies in terms of clinical indications, surgical outcomes, complications, and mortality in a tertiary care center.

Methods

We conducted a retrospective observational study including all patients undergoing renal allograft nephrectomy between January 2010 and July 2024. Patients were stratified into early and late nephrectomy groups. Data were analyzed regarding demographic characteristics, indications, urgency, surgical technique, complications (Clavien-Dindo classification), transfusion requirements, length of stay, and follow-up outcomes.

Results

Among 109 nephrectomies (11.0% of 985 transplants), 55 were early and 54 were late. Early nephrectomies were more frequently urgent (87.3% vs 29.6%, P < .001) and associated with higher transfusion rates, longer hospitalization (median 16 vs 10 days, P = .011), and more complications (22.8% vs 12.7%, P = .164). Major indications differed: vascular thrombosis and hemorrhagic shock were predominant in early nephrectomies, while chronic rejection and infection prevailed in late cases. Urgent nephrectomies, irrespective of timing, were linked to significantly higher complication rates (P < .001). No intraoperative deaths occurred, but all 3 postoperative deaths were in the early group.

Conclusions

Early allograft nephrectomies, typically performed for urgent complications, are associated with increased morbidity, transfusion needs, and hospital stay. Late nephrectomies, often elective, have been associated with better postoperative outcomes. These findings underscore the need for standardized guidelines and prospective studies to optimize the management of failed renal grafts.
背景:同种异体肾移植切除术仍然是一个复杂和高风险的手术,通常在移植失败后进行。虽然其适应症和结果各不相同,但最佳的肾切除术时间仍然存在争议。目的:比较早期(移植后≤60天)和晚期(移植后≤60天)同种异体肾切除术在临床适应证、手术结果、并发症和死亡率方面的差异。方法:我们对2010年1月至2024年7月接受同种异体肾切除术的所有患者进行回顾性观察研究。患者分为早期和晚期肾切除术组。数据分析包括人口统计学特征、适应症、紧急情况、手术技术、并发症(Clavien-Dindo分类)、输血需求、住院时间和随访结果。结果:109例肾切除术中,早期55例,晚期54例,占985例移植的11.0%。早期肾切除术更为急症(87.3% vs 29.6%, P < 0.001),并与较高的输血率、较长的住院时间(中位16天vs 10天,P = 0.011)和更多的并发症(22.8% vs 12.7%, P = 0.164)相关。主要适应症不同:早期肾切除术以血管血栓形成和失血性休克为主,而晚期以慢性排斥反应和感染为主。无论何时进行紧急肾切除术,其并发症发生率均显著升高(P < 0.001)。术中无死亡发生,术后3例死亡均发生在早期组。结论:早期同种异体移植肾切除术,通常用于紧急并发症,与增加的发病率,输血需求和住院时间有关。晚期肾切除术,通常是选择性的,与较好的术后预后相关。这些发现强调需要标准化的指南和前瞻性研究来优化肾移植失败的管理。
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引用次数: 0
The 15th Turkish Transplantation Centers Coordination Association (TTCCA) MeetingGaziantep, TurkeyOctober 17-20, 2024Guest Editor: Sukru EmreCo-Guest Editor: Kamil Yalcin Polat 第15届土耳其移植中心协调协会(TTCCA)会议将于2024年10月17日至20日在土耳其加济安泰普举行
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/S0041-1345(25)00496-8
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引用次数: 0
Effectiveness of Variceal Band Application in Preventing Bile Leakage Associated With Trans-Cystic Feeding Catheter in Living-Donor Liver Transplantation 静脉曲张带在活体肝移植中预防经囊性喂养管胆漏中的应用效果。
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.06.014
Adem Tuncer , Canan Dilay Dirican , Emrah Sahin , Veysel Ersan , Feyza Sönmez Topcu , Hasret Ayyıldız Civan , Bülent Unal , Abuzer Dirican

Objective

Despite advancements in surgical techniques, biliary complications remain a significant concern in liver transplantation. This study evaluated the effectiveness of applying a variceal band to the cystic duct stump in preventing bile leakage in patients with a trans-cystic feeding catheter.

Methods

The medical records of 328 liver transplant recipients between April 2022 and June 2024 were retrospectively reviewed. A total of 170 patients with trans-cystic external catheters were included in the study. Of these, 116 patients underwent variceal band application to the cystic duct stump, while 54 did not. The 2 groups were compared regarding demographic characteristics, graft weight, number of bile ducts, presence of bile leakage, and MELD scores.

Results

Among the 170 patients who underwent living-donor liver transplantation (LDLT), 58.8% were male, and 41.2% were female. Graft weight was significantly higher in the group with the variceal band application (p < .05). Bile leakage from the cystic duct stump occurred in 2 patients in the group without variceal banding, whereas no bile leakage was observed in the variceal band group. These 2 cases were successfully treated with percutaneous catheter placement under radiologic guidance.

Conclusion

The variceal band application is an effective and promising method for reducing bile leakage in LDLT patients utilizing a trans-cystic feeding catheter. However, multicenter studies with larger patient cohorts are necessary to more definitively assess the safety and efficacy of this technique.
目的:尽管手术技术进步,胆道并发症仍然是肝移植的一个重要问题。本研究评估了在胆囊管残端应用静脉曲张带防止经囊性喂养导管患者胆漏的有效性。方法:回顾性分析2022年4月至2024年6月328例肝移植受者的病历。本研究共纳入170例经囊外置管患者。其中,116例患者接受了囊管残端静脉曲张绑扎术,54例未行。比较两组患者的人口学特征、移植物重量、胆管数量、胆漏情况和MELD评分。结果:170例活体肝移植患者中,男性占58.8%,女性占41.2%。静脉曲张带组移植物重量显著高于静脉曲张带组(p < 0.05)。无静脉曲张束带组2例患者出现胆囊管残端胆漏,而有静脉曲张束带组未见胆漏。2例均在放射学指导下经皮置管治疗成功。结论:静脉曲张带是减少LDLT患者经囊性喂食管胆漏的有效方法。然而,为了更明确地评估该技术的安全性和有效性,需要更多患者队列的多中心研究。
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引用次数: 0
Monitoring CD3(+) T Cells in Kidney Transplantation and Immunosuppression Adequacy 肾移植中CD3(+) T细胞监测与免疫抑制充分性。
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.06.016
Kemal Eyvaz MD, FEBS, FACS, Arif Aslaner MD, FACS, Arif Ata Kiravkazli MD

Background

Monitoring CD3(+) T-cell counts in kidney transplant recipients can provide valuable insights into immunosuppressive therapy effectiveness. This study aimed to evaluate the use of CD3(+) T-cell levels as biomarkers for immunosuppression adequacy and to assess their predictive value for acute rejection post-transplantation.

Methods

A retrospective review was conducted involving 130 kidney transplant recipients who received induction therapy with antithymocyte globulin (ATG). CD3(+) T-cell percentages and absolute counts were measured using flow cytometry on postoperative day 5. Immunosuppression was maintained with tacrolimus, initiated upon clinical indicators of graft function recovery.

Results

Among monitored patients, the median CD3(+) T-cell percentage was 48%, and median absolute count was 0.14 × 10⁹/L. Acute rejection occurred in 9.9% of recipients. Higher CD3(+) T-cell values significantly correlated with acute rejection (64.0% vs 47.5%, p = .011; absolute count 0.28 vs 0.13 × 10⁹/L, p = .032). ROC analysis identified optimal predictive thresholds: 54% for CD3(+) percentage (sensitivity 85.7%, specificity 73.4%) and 0.21 × 10⁹/L for absolute count (sensitivity 85.7%, specificity 75.0%).

Conclusions

CD3(+) T-cell monitoring effectively guides individualized immunosuppressive strategies, significantly predicting acute rejection risks and optimizing graft outcomes.
背景:监测肾移植受者的CD3(+) t细胞计数可以为免疫抑制治疗的有效性提供有价值的见解。本研究旨在评估CD3(+) t细胞水平作为免疫抑制充分性的生物标志物的使用,并评估其对移植后急性排斥反应的预测价值。方法:对130例接受抗胸腺细胞球蛋白(ATG)诱导治疗的肾移植患者进行回顾性分析。术后第5天用流式细胞术检测CD3(+) t细胞百分比和绝对计数。根据移植物功能恢复的临床指标,他克莫司维持免疫抑制。结果:在监测的患者中,CD3(+) t细胞百分比中位数为48%,绝对计数中位数为0.14 × 10⁹/L。9.9%的受者发生急性排斥反应。高CD3(+) t细胞值与急性排斥反应显著相关(64.0% vs 47.5%, p = 0.011;绝对计数0.28 vs 0.13 × 10⁹/L, p = 0.032)。ROC分析确定了最佳预测阈值:CD3(+)百分比为54%(敏感性85.7%,特异性73.4%),绝对计数为0.21 × 10⁹/L(敏感性85.7%,特异性75.0%)。结论:CD3(+) t细胞监测可有效指导个体化免疫抑制策略,显著预测急性排斥风险和优化移植结果。
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引用次数: 0
The Effect of Portal Vein Variants on the Margin of Error in Graft Volume Calculation in Living Donor Right Lobe Liver Transplantation 门静脉变异对活体右肝移植移植物体积计算误差范围的影响。
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.06.017
Feyza Sönmez Topcu , Veysel Ersan , Emrah Şahin , Adem Tunçer , Hasret Ayyıldız Civan , Abuzer Dirican , Bülent Ünal

Background

Selecting the appropriate graft for living donor liver transplantation requires accurate calculation of estimated graft volume.

Purpose

To investigate the error rate in graft volume calculation in the preoperative evaluation of donor liver and the contribution of donor portal vein type to the error margin.

Material and Methods

The study included 197 right lobe liver donors. Estimated graft volume calculations based on preoperative radiological images of donors were retrospectively reviewed. Demographic data of the donors and liver portal vein type were recorded. The proportional differences between the weight of the right lobe graft removed during transplantation and the estimated volume were calculated separately according to the portal vein groups. The margin of error in the estimated graft volume measurement and the effect of portal vein type were statistically evaluated.

Results

Considering all donors, estimated preoperative volume was calculated to be 6.877% higher than actual graft weight on average. Preoperative estimated graft volume was on average 5.746% higher for Type 1, 8.311% higher for Type 2, and finally 17.883% higher for Type 3 portal vein variant. It was shown that, as the portal vein anatomy in the donor becomes more complex, the negatively proportional difference in preoperative volume estimation increases.

Conclusion

Volume estimation showed a negative proportional difference for all three variants of the portal vein. Especially, the presence of a Type 3 portal vein in the liver graft may cause more errors in preoperative graft volume calculation.
背景:为活体供肝移植选择合适的移植物需要准确计算估计的移植物体积。目的:探讨供肝术前评估中移植物体积计算的错误率及供肝门静脉类型对错误率的贡献。材料与方法:197例右肝供体。基于供体术前放射影像估计移植物体积的计算被回顾性回顾。记录供体及肝门静脉类型的人口学资料。根据门静脉组分别计算移植过程中切除的右叶移植物重量与估计体积的比例差异。对估计移植物体积测量的误差范围和门静脉类型的影响进行统计评估。结果:考虑所有供体,术前估计体积比实际移植重量平均高6.877%。术前估计移植物体积1型增加5.746%,2型增加8.311%,3型增加17.883%。研究表明,随着供体门静脉解剖结构变得更加复杂,术前体积估计的负比例差异增加。结论:门静脉三种变型的体积估计呈负比例差异。尤其是肝移植物中存在3型门静脉,可能会导致术前移植物体积计算出现更多误差。
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引用次数: 0
Experiences of Potential Living Donors Who Withdrew From Liver Donor Evaluation: A Qualitative Study 潜在活体供者退出肝供者评估的经验:一项定性研究。
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.08.006
Tugba Nur Oden , Tufan Gumus , Sirin Vatansever Durmus , Alper Uguz

Background

Understanding the psychological, emotional, and managerial challenges faced by potential donors is essential for the proper management of the living donor evaluation process, and appropriate solutions need to be developed for these challenges. This study aimed to explore the experiences of potential liver donors who voluntarily withdrew from the living donor evaluation process.

Methods

A phenomenological qualitative design was employed. Ten participants who had voluntarily withdrawn from the living donor evaluation process were interviewed. Three main themes were identified: (1) Experiences Related to the Evaluation Process, (2) Reasons for the Withdrawal Decision, and (3) Recommendations regarding the potential donor evaluation process.

Results

Positive experiences included adequate information sharing, emotional support, psychiatric consultations, and support from hospital staff. Negative experiences focused on prolonged waiting times, psychological and emotional barriers, systemic and organizational issues. Key reasons for withdrawal included concerns about health and surgical risks, family responsibilities, psychological unpreparedness, and organizational difficulties experienced throughout the evaluation process. Participants suggested accelerating hospital procedures, improving communication with specialists, offering accommodation during the evaluation process, and increasing public awareness about organ donation.

Conclusions

The findings emphasize the need to improve the living donor evaluation process. Prioritizing donor candidates, expediting procedures, and developing donor support programs that address physical, emotional, financial, and systemic needs may enhance the effectiveness of living donor transplantation.
背景:了解潜在捐赠者面临的心理、情感和管理方面的挑战,对于正确管理活体捐赠者评估过程至关重要,需要针对这些挑战制定适当的解决方案。本研究旨在探讨自愿退出活体供者评估过程的潜在肝供者的经历。方法:采用现象学定性设计。十位自愿退出活体捐献者评估过程的参与者接受了采访。确定了三个主要主题:(1)与评估过程相关的经验;(2)退出决定的原因;(3)关于潜在捐助者评估过程的建议。结果:积极体验包括充分的信息分享、情感支持、精神咨询和医院工作人员的支持。消极体验主要集中在等待时间过长、心理和情感障碍、系统和组织问题上。退出的主要原因包括担心健康和手术风险、家庭责任、心理准备不足以及在整个评估过程中遇到的组织困难。与会者建议加快医院程序,改善与专家的沟通,在评估过程中提供住宿,以及提高公众对器官捐赠的认识。结论:研究结果强调了改进活体供体评估过程的必要性。优先考虑供体候选人,加快程序,制定供体支持计划,解决身体,情感,经济和系统需求,可以提高活体供体移植的有效性。
{"title":"Experiences of Potential Living Donors Who Withdrew From Liver Donor Evaluation: A Qualitative Study","authors":"Tugba Nur Oden ,&nbsp;Tufan Gumus ,&nbsp;Sirin Vatansever Durmus ,&nbsp;Alper Uguz","doi":"10.1016/j.transproceed.2025.08.006","DOIUrl":"10.1016/j.transproceed.2025.08.006","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the psychological, emotional, and managerial challenges faced by potential donors is essential for the proper management of the living donor evaluation process, and appropriate solutions need to be developed for these challenges. This study aimed to explore the experiences of potential liver donors who voluntarily withdrew from the living donor evaluation process.</div></div><div><h3>Methods</h3><div>A phenomenological qualitative design was employed. Ten participants who had voluntarily withdrawn from the living donor evaluation process were interviewed. Three main themes were identified: (1) Experiences Related to the Evaluation Process, (2) Reasons for the Withdrawal Decision, and (3) Recommendations regarding the potential donor evaluation process.</div></div><div><h3>Results</h3><div>Positive experiences included adequate information sharing, emotional support, psychiatric consultations, and support from hospital staff. Negative experiences focused on prolonged waiting times, psychological and emotional barriers, systemic and organizational issues. Key reasons for withdrawal included concerns about health and surgical risks, family responsibilities, psychological unpreparedness, and organizational difficulties experienced throughout the evaluation process. Participants suggested accelerating hospital procedures, improving communication with specialists, offering accommodation during the evaluation process, and increasing public awareness about organ donation.</div></div><div><h3>Conclusions</h3><div>The findings emphasize the need to improve the living donor evaluation process. Prioritizing donor candidates, expediting procedures, and developing donor support programs that address physical, emotional, financial, and systemic needs may enhance the effectiveness of living donor transplantation.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Pages 1691-1696"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TTCCA 2024 Meeting Preface ttcca2024年会议序
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.10.002
{"title":"TTCCA 2024 Meeting Preface","authors":"","doi":"10.1016/j.transproceed.2025.10.002","DOIUrl":"10.1016/j.transproceed.2025.10.002","url":null,"abstract":"","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Page 1690"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HALP Score Predicts Early Post-Transplant Outcomes: A 25-Year Retrospective Study on Hepatocellular Carcinoma and Liver Transplantation Outcomes HALP评分预测移植后早期预后:一项25年肝细胞癌和肝移植预后的回顾性研究。
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.08.001
Cihan Agalar , Tufan Egeli , Anil Aysal , Mucahit Ozbilgin , Berkay Sakaoglu , Nilay Danis , Emre Karadeniz , Erhan Tükel , Ibrahim Astarcioglu , Ozgul Sagol , Tarkan Unek

Aim

The Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score is an immune nutritional marker associated with prognosis in various malignancies. However, its prognostic significance in liver transplantation (LT) for hepatocellular carcinoma (HCC) remains unexplored. This study investigates the prognostic impact of the HALP score on post-transplant survival and recurrence in HCC patients.

Patients and Methods

A retrospective cohort study included 131 patients who underwent Liver Transplantation for HCC between 1998 and 2023. Patients were stratified into high and low HALP groups based on a threshold value of 55.689 determined via receiver operating characteristic (ROC) analysis. Overall survival (OS), disease-free survival (DFS), and perioperative mortality were analyzed using Kaplan-Meier and Cox regression models.

Results

The low HALP group exhibited significantly higher perioperative mortality (18.3% vs. 5.6%, P = .003), first-year mortality (30.0% vs. 9.9%, P = .001), and three-year mortality (48.3% vs. 22.5%, P = .001). Overall survival was significantly shorter in the low HALP group (P = .003).
Multivariate analysis identified low HALP as an independent risk factor for perioperative (OR: 12.76, P = .019; HR: 11.68, P = .021), first-year (OR: 5.19, P = .005; HR: 4.22, P = .007) and third-year mortality (OR: 3.67, P = .01; HR: 2.88, P = .012).

Conclusion

The HALP score is a promising prognostic biomarker for predicting early risk in LT candidates with HCC. Integrating HALP into pre-transplant assessment may optimize patient selection and perioperative management, improving post-transplant outcomes.
目的:血红蛋白-白蛋白-淋巴细胞-血小板(HALP)评分是一种与各种恶性肿瘤预后相关的免疫营养指标。然而,其在肝移植(LT)治疗肝细胞癌(HCC)中的预后意义仍未被探索。本研究探讨了HALP评分对HCC患者移植后生存和复发的预后影响。患者和方法:一项回顾性队列研究纳入了1998年至2023年间131例因HCC接受肝移植的患者。根据受试者工作特征(ROC)分析确定的阈值55.689将患者分为高HALP组和低HALP组。采用Kaplan-Meier和Cox回归模型分析总生存期(OS)、无病生存期(DFS)和围手术期死亡率。结果:低HALP组围手术期死亡率(18.3% vs. 5.6%, P = 0.003)、第一年死亡率(30.0% vs. 9.9%, P = 0.001)和三年死亡率(48.3% vs. 22.5%, P = 0.001)均显著高于低HALP组。低HALP组总生存期明显缩短(P = 0.003)。多因素分析发现,低HALP是围手术期(OR: 12.76, P = 0.019; HR: 11.68, P = 0.021)、第一年(OR: 5.19, P = 0.005; HR: 4.22, P = 0.007)和第三年死亡率(OR: 3.67, P = 0.01; HR: 2.88, P = 0.012)的独立危险因素。结论:HALP评分是一种有希望预测肝细胞癌肝移植患者早期风险的预后生物标志物。将HALP纳入移植前评估可以优化患者选择和围手术期管理,改善移植后预后。
{"title":"HALP Score Predicts Early Post-Transplant Outcomes: A 25-Year Retrospective Study on Hepatocellular Carcinoma and Liver Transplantation Outcomes","authors":"Cihan Agalar ,&nbsp;Tufan Egeli ,&nbsp;Anil Aysal ,&nbsp;Mucahit Ozbilgin ,&nbsp;Berkay Sakaoglu ,&nbsp;Nilay Danis ,&nbsp;Emre Karadeniz ,&nbsp;Erhan Tükel ,&nbsp;Ibrahim Astarcioglu ,&nbsp;Ozgul Sagol ,&nbsp;Tarkan Unek","doi":"10.1016/j.transproceed.2025.08.001","DOIUrl":"10.1016/j.transproceed.2025.08.001","url":null,"abstract":"<div><h3>Aim</h3><div>The Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score is an immune nutritional marker associated with prognosis in various malignancies. However, its prognostic significance in liver transplantation (LT) for hepatocellular carcinoma (HCC) remains unexplored. This study investigates the prognostic impact of the HALP score on post-transplant survival and recurrence in HCC patients.</div></div><div><h3>Patients and Methods</h3><div>A retrospective cohort study included 131 patients who underwent Liver Transplantation for HCC between 1998 and 2023. Patients were stratified into high and low HALP groups based on a threshold value of 55.689 determined via receiver operating characteristic (ROC) analysis. Overall survival (OS), disease-free survival (DFS), and perioperative mortality were analyzed using Kaplan-Meier and Cox regression models.</div></div><div><h3>Results</h3><div>The low HALP group exhibited significantly higher perioperative mortality (18.3% vs. 5.6%, <em>P = .</em>003), first-year mortality (30.0% vs. 9.9%, <em>P = .</em>001), and three-year mortality (48.3% vs. 22.5%, <em>P = .</em>001). Overall survival was significantly shorter in the low HALP group (<em>P = .</em>003).</div><div>Multivariate analysis identified low HALP as an independent risk factor for perioperative (OR: 12.76, <em>P = .</em>019; HR: 11.68, <em>P = .</em>021), first-year (OR: 5.19, <em>P = .</em>005; HR: 4.22, <em>P = .</em>007) and third-year mortality (OR: 3.67, <em>P = .</em>01; HR: 2.88, <em>P = .</em>012).</div></div><div><h3>Conclusion</h3><div>The HALP score is a promising prognostic biomarker for predicting early risk in LT candidates with HCC. Integrating HALP into pre-transplant assessment may optimize patient selection and perioperative management, improving post-transplant outcomes.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Pages 1793-1798"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Living Donor Liver Transplantation in Patients With Portal Vein Thrombosis: A Single-Center Experience 活体肝移植在门静脉血栓患者中的应用:单中心研究。
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.08.011
Emrah Sahin , Adem Tuncer , Feyza Sönmez Topcu , Veysel Ersan , Hasret Ayyıldız Civan , Abuzer Dirican , Bülent Ünal

Background

Portal vein thrombosis (PVT) is a significant vascular complication in liver transplant candidates, necessitating modifications in surgical techniques and increasing the risk of postoperative complications. This study aimed to evaluate postoperative thrombotic complications, the need for reoperation, survival, and mortality rates after living donor liver transplantation (LDLT) in patients with preoperative PVT.

Methods

Forty-nine patients diagnosed with preoperative PVT undergoing LDLT between July 2021 and August 2024 at our center were retrospectively reviewed. Patients were classified according to the Yerdel classification. Surgical techniques, portal vein reconstruction, associated diseases, MELD/PELD scores, postoperative PVT occurrence, the need for reoperation, and survival data were analyzed.

Results

Postoperative PVT developed in 6 patients (12.2%); 3 of these patients (6.1%) required reoperation. Overall, mortality occurred in 13 patients (26.5%); 3 cases were due to non-PVT-related reasons (sepsis following ERCP/PTC or sudden cardiac arrest). The PVT-related mortality rate was 20.4% (10 patients). Mortality was observed in 4 (66.7%) patients with postoperative PVT. Among 8 patients with Yerdel Grade 3-4 PVT, postoperative PVT occurred in 2 patients (25%). Thrombosis occurred in 2 of 6 patients (33.3%) who underwent graft reconstruction; 1 required reoperation. Portal flow was successfully restored in 83.3% of reconstructed cases. Patients developing postoperative PVT had a higher mean MELD/PELD score (22.5 vs. 19.2), an average age of 48.8 years, and equal gender distribution. The mean follow-up period was 14.2 months overall and 7.7 months in patients with postoperative PVT. Comorbidities (diabetes, hypertension, cardiac, or pulmonary pathology) were present in approximately 50% of patients with postoperative PVT and 62% of those who died. The most common preoperative diagnoses were cryptogenic cirrhosis (22.4%), NASH (18.3%), and HBV infection (16.3%).

Conclusion

Preoperative PVT significantly correlates with postoperative PVT development and mortality following LDLT. Advanced Yerdel stages, high MELD/PELD scores, and the necessity for portal vein reconstruction increase this risk. Early diagnosis, close imaging follow-up, and proper anticoagulation management postoperatively are crucial. Our findings highlight the importance of a multidisciplinary approach in surgical planning and lay the groundwork for prospective, multi-center studies.
背景:门静脉血栓形成(PVT)是肝移植候选人的重要血管并发症,需要修改手术技术并增加术后并发症的风险。本研究旨在评估术前PVT患者的术后血栓性并发症、再手术需求、生存率和死亡率。方法:回顾性分析本中心2021年7月至2024年8月期间49例确诊为术前PVT的患者行活体肝移植手术。根据Yerdel分类对患者进行分类。分析手术技术、门静脉重建、相关疾病、MELD/PELD评分、术后PVT发生、再次手术的需要和生存数据。结果:术后发生PVT 6例(12.2%);其中3例(6.1%)需要再手术。总体而言,13例患者死亡(26.5%);3例与pvt无关的原因(ERCP/PTC后脓毒症或心脏骤停)。pvt相关死亡率为20.4%(10例)。4例(66.7%)术后PVT患者死亡,8例Yerdel 3-4级PVT患者中2例(25%)术后发生PVT。6例移植物重建患者中2例(33.3%)发生血栓形成;我需要重新手术。门静脉血流恢复成功率为83.3%。术后发生PVT的患者平均MELD/PELD评分较高(22.5比19.2),平均年龄为48.8岁,性别分布相同。总体平均随访时间为14.2个月,术后PVT患者平均随访时间为7.7个月。约50%的术后PVT患者存在合并症(糖尿病、高血压、心脏或肺部病理),62%的患者死亡。最常见的术前诊断为隐源性肝硬化(22.4%)、NASH(18.3%)和HBV感染(16.3%)。结论:术前PVT与LDLT术后PVT发展及死亡率显著相关。Yerdel分期高,MELD/PELD评分高,门静脉重建的必要性增加了这种风险。早期诊断,密切的影像学随访,术后适当的抗凝治疗是至关重要的。我们的发现强调了多学科方法在手术计划中的重要性,并为前瞻性多中心研究奠定了基础。
{"title":"Living Donor Liver Transplantation in Patients With Portal Vein Thrombosis: A Single-Center Experience","authors":"Emrah Sahin ,&nbsp;Adem Tuncer ,&nbsp;Feyza Sönmez Topcu ,&nbsp;Veysel Ersan ,&nbsp;Hasret Ayyıldız Civan ,&nbsp;Abuzer Dirican ,&nbsp;Bülent Ünal","doi":"10.1016/j.transproceed.2025.08.011","DOIUrl":"10.1016/j.transproceed.2025.08.011","url":null,"abstract":"<div><h3>Background</h3><div>Portal vein thrombosis (PVT) is a significant vascular complication in liver transplant candidates, necessitating modifications in surgical techniques and increasing the risk of postoperative complications. This study aimed to evaluate postoperative thrombotic complications, the need for reoperation, survival, and mortality rates after living donor liver transplantation (LDLT) in patients with preoperative PVT.</div></div><div><h3>Methods</h3><div>Forty-nine patients diagnosed with preoperative PVT undergoing LDLT between July 2021 and August 2024 at our center were retrospectively reviewed. Patients were classified according to the Yerdel classification. Surgical techniques, portal vein reconstruction, associated diseases, MELD/PELD scores, postoperative PVT occurrence, the need for reoperation, and survival data were analyzed.</div></div><div><h3>Results</h3><div>Postoperative PVT developed in 6 patients (12.2%); 3 of these patients (6.1%) required reoperation. Overall, mortality occurred in 13 patients (26.5%); 3 cases were due to non-PVT-related reasons (sepsis following ERCP/PTC or sudden cardiac arrest). The PVT-related mortality rate was 20.4% (10 patients). Mortality was observed in 4 (66.7%) patients with postoperative PVT. Among 8 patients with Yerdel Grade 3-4 PVT, postoperative PVT occurred in 2 patients (25%). Thrombosis occurred in 2 of 6 patients (33.3%) who underwent graft reconstruction; 1 required reoperation. Portal flow was successfully restored in 83.3% of reconstructed cases. Patients developing postoperative PVT had a higher mean MELD/PELD score (22.5 vs. 19.2), an average age of 48.8 years, and equal gender distribution. The mean follow-up period was 14.2 months overall and 7.7 months in patients with postoperative PVT. Comorbidities (diabetes, hypertension, cardiac, or pulmonary pathology) were present in approximately 50% of patients with postoperative PVT and 62% of those who died. The most common preoperative diagnoses were cryptogenic cirrhosis (22.4%), NASH (18.3%), and HBV infection (16.3%).</div></div><div><h3>Conclusion</h3><div>Preoperative PVT significantly correlates with postoperative PVT development and mortality following LDLT. Advanced Yerdel stages, high MELD/PELD scores, and the necessity for portal vein reconstruction increase this risk. Early diagnosis, close imaging follow-up, and proper anticoagulation management postoperatively are crucial. Our findings highlight the importance of a multidisciplinary approach in surgical planning and lay the groundwork for prospective, multi-center studies.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Pages 1808-1811"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Non-neoplastic Portal Vein Thrombosis in Adult Living Donor Liver Transplantation 成人活体肝移植非肿瘤性门静脉血栓的处理。
IF 0.8 4区 医学 Q4 IMMUNOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.transproceed.2025.09.001
Kamil Yalçın Polat , Şerafettin Yazar , Ahmet Kargı , Serdar Aslan , Bünyamin Gürbulak , Vusal Abdurrahmanov , İbrahim Astarcıoğlu

Background

Nontumoral portal vein thrombosis (PVT) refers to thrombotic occlusion of the PV, affecting both superior mesenteric vein (SMV) and splenic vein owing to portal hypertension in cirrhotic patients. Nontumoral PVT is more frequent in cirrhotic patients with a prevalence ranging from 10-14% to 25%.

Method

We evaluated the prevalence, morbidity (rethrombosis, ascites), mortality survival rates and contributing factors in patients with PVT (preoperative/perioperative) who underwent PV thromboendovenectomy.

Results

We performed 522 living donor liver transplantations between November 2021 and 2024; 82 patients (46 male/36 female) had non-neoplastic chronic cruoric PVT. The prevalence of PVT is 15.7%. Forty-four patients were classified as Yerdel I, 19 as Yerdel II, and 19 as Yerdel III; 53 patients (65%) had a Model for End-Stage Liver Disease (MELD) score of <15. Rethrombosis was seen in 4 cases (4.87%) and 2 patients died. Twelve mortalities were seen (14.63 %). Two of the 12 deaths were related to rethrombosis.

Conclusion

Our mortality rates were similar in patients with and without PVT, and PVT had no impact on mortality. When chronic PVT is detected, transplantation should not be delayed, even if the MELD score is low, because PVT can progress faster than MELD, ultimately increasing mortality.
背景:非肿瘤性门静脉血栓形成(PVT)是指肝硬化患者由于门静脉高压导致门静脉血栓性闭塞,同时影响肠系膜上静脉(SMV)和脾静脉。非肿瘤性PVT在肝硬化患者中更为常见,患病率在10-14%至25%之间。方法:我们评估了PVT患者(术前/围手术期)接受PVT血栓腔内切除术的患病率、发病率(再血栓形成、腹水)、死亡率、生存率和影响因素。结果:我们在2021年11月至2024年11月期间进行了522例活体肝移植;82例(男46例,女36例)存在非肿瘤性慢性血栓性PVT,患病率为15.7%。Yerdel I型44例,Yerdel II型19例,Yerdel III型19例;53例(65%)患者的终末期肝病模型(MELD)评分为:结论:我们的死亡率在有和没有PVT的患者中相似,PVT对死亡率没有影响。当发现慢性PVT时,即使MELD评分较低,也不应延迟移植,因为PVT的进展比MELD更快,最终增加死亡率。
{"title":"Management of Non-neoplastic Portal Vein Thrombosis in Adult Living Donor Liver Transplantation","authors":"Kamil Yalçın Polat ,&nbsp;Şerafettin Yazar ,&nbsp;Ahmet Kargı ,&nbsp;Serdar Aslan ,&nbsp;Bünyamin Gürbulak ,&nbsp;Vusal Abdurrahmanov ,&nbsp;İbrahim Astarcıoğlu","doi":"10.1016/j.transproceed.2025.09.001","DOIUrl":"10.1016/j.transproceed.2025.09.001","url":null,"abstract":"<div><h3>Background</h3><div>Nontumoral portal vein thrombosis (PVT) refers to thrombotic occlusion of the PV, affecting both superior mesenteric vein (SMV) and splenic vein owing to portal hypertension in cirrhotic patients. Nontumoral PVT is more frequent in cirrhotic patients with a prevalence ranging from 10-14% to 25%.</div></div><div><h3>Method</h3><div>We evaluated the prevalence, morbidity (rethrombosis, ascites), mortality survival rates and contributing factors in patients with PVT (preoperative/perioperative) who underwent PV thromboendovenectomy.</div></div><div><h3>Results</h3><div>We performed 522 living donor liver transplantations between November 2021 and 2024; 82 patients (46 male/36 female) had non-neoplastic chronic cruoric PVT. The prevalence of PVT is 15.7%. Forty-four patients were classified as Yerdel I, 19 as Yerdel II, and 19 as Yerdel III; 53 patients (65%) had a Model for End-Stage Liver Disease (MELD) score of &lt;15. Rethrombosis was seen in 4 cases (4.87%) and 2 patients died. Twelve mortalities were seen (14.63 %). Two of the 12 deaths were related to rethrombosis.</div></div><div><h3>Conclusion</h3><div>Our mortality rates were similar in patients with and without PVT, and PVT had no impact on mortality. When chronic PVT is detected, transplantation should not be delayed, even if the MELD score is low, because PVT can progress faster than MELD, ultimately increasing mortality.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 9","pages":"Pages 1804-1807"},"PeriodicalIF":0.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Transplantation proceedings
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