Transplantation proceedings最新文献

{"title":"Correlation Study of LncRNA H19 Single Nucleotide Polymorphism With Delayed Graft Function of Transplanted Kidney: A Retrospective Study","authors":"Xiaoping He ,&nbsp;Lisong Wan ,&nbsp;Youfu Zhang,&nbsp;Xuyang Wang,&nbsp;Gang Liu,&nbsp;Xinchang Li,&nbsp;Chengmei Long,&nbsp;Hua Yang,&nbsp;Tongchang Chen,&nbsp;Jinran Yang","doi":"10.1016/j.transproceed.2025.12.006","DOIUrl":"10.1016/j.transproceed.2025.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between LncRNA H19 single nucleotide polymorphisms and delayed graft function.</div></div><div><h3>Methods</h3><div>This retrospective study included 827 kidney transplantations performed between January 1, 2015, and December 31, 2022, and fifty recipients with delayed graft function were assigned to the DGF group, while fifty recipients with immediate graft function were assigned to the IGF group. The DGF recipients and the IGF recipients had donor kidneys from the same donor. Single nucleotide polymorphisms (SNPs) of LncRNA H19 (rs217727, rs2067051, rs2251375, rs492994, rs2839698, and rs10732516) were genotyped using peripheral blood samples, rs2067051, rs2251375, rs492994, rs2839698 and rs10732516.</div></div><div><h3>Results</h3><div>Patients in the DGF group had 43 homozygous, 2 wild-type, and 5 heterozygous rs492994 gene loci, and 38 homozygous, 2 wild-type, and 10 heterozygous rs2839698 gene loci. Patients in the IGF group had 34 homozygous, 2 wild-type, and 14 heterozygous rs492994 gene loci, and 48 homozygous, 1 wild-type, and 1 heterozygous rs2839698 gene loci. There were differences in SNP between the DGF group and the IGF group at the rs492994 and rs2839698 gene loci, with <em>P &lt;</em> .05 and statistically significant differences. However, there was no statistically significant difference in SNP at the other 4 gene loci, with <em>P &gt;</em> .05. Since the donor kidneys in the DGF group and the IGF group come from the same donor, their donor data are identical and there are no differences. However, there were no significant differences between the 2 groups in donor kidney laterality, cold ischemia time, vascular anastomosis time, or key recipient characteristics (e.g., age, gender, body mass index, HLA mismatch rate) (all <em>P</em> &gt; .05).</div></div><div><h3>Conclusion</h3><div>The polymorphisms rs492994 and rs2839698 in LncRNA H19 are significantly associated with the occurrence of DGF after kidney transplantation.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 75-82"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inefficacy of Intraoperative Renal Replacement Therapy in Mitigating Early Allograft Dysfunction Among Liver Transplant Recipients: A Propensity Score Matched Study","authors":"Sabrina Rezaoui ,&nbsp;Anne Bignon ,&nbsp;Joséphine Vogel ,&nbsp;Pauline Devauchelle ,&nbsp;Gilles Lebuffe ,&nbsp;Alexandre Chebaro ,&nbsp;Fanny Lebossé ,&nbsp;Mathieu Gazon ,&nbsp;Frederic Aubrun ,&nbsp;Guillaume Rossignol ,&nbsp;Kayvan Mohkam ,&nbsp;Céline Guichon","doi":"10.1016/j.transproceed.2025.11.012","DOIUrl":"10.1016/j.transproceed.2025.11.012","url":null,"abstract":"<div><h3>Background</h3><div>Intraoperative continuous renal replacement therapy (IoCRRT) represents a viable approach for managing the hemodynamic and metabolic challenges encountered during liver transplantation (LT), particularly in high-acuity patients. Our objective was to evaluate the impact of IoCRRT in comparison with conservative treatment on liver graft function during the immediate post-transplant period.</div></div><div><h3>Methods</h3><div>This retrospective, bicentric cohort study included patients who underwent LT between January 2014 and December 2019. Propensity score matching was conducted to mitigate disparities between the IoCRRT and control groups. Comparative analysis of post-transplant outcomes encompassed early allograft dysfunction (EAD), as defined by Olthoff, along with quantitative evaluation using the Model for Early Allograft Function (MEAF) scoring.</div></div><div><h3>Results</h3><div>The analysis included 73 patients in both groups, demonstrating comparability, with a mean MELD score of 31.5 ± 9.4 in the IoCRRT group compared to 30.6 ± 9.6 (SMD, Standardized mean difference = 0.088) in the control group. The overall frequency of EAD was 32.9% in the IoCRRT group and 43.8% in the control group (<em>P</em> = .243), with quantitative assessment using the MEAF score yielding 6.81 versus 6.89 (<em>P</em> = .843), respectively. No significant differences were observed in the length of stay in the intensive care unit or 90-day mortality.</div></div><div><h3>Conclusions</h3><div>Implementation of IoCRRT during LT did not correlate with a reduction in the occurrence or severity of early allograft dysfunction.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 119-125"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Full and In-situ Split Domino Living Donor Liver Transplants Experience","authors":"Kamil Yalçın Polat ,&nbsp;Ahmet Kargı ,&nbsp;Şerafettin Yazar ,&nbsp;Serdar Aslan ,&nbsp;Bünyamin Gürbulak ,&nbsp;Fulya Kamit ,&nbsp;Selim Gökçe ,&nbsp;Ibrahim Astarcıoğlu","doi":"10.1016/j.transproceed.2025.12.012","DOIUrl":"10.1016/j.transproceed.2025.12.012","url":null,"abstract":"<div><h3>Background</h3><div>Domino liver transplantation (DLT) is a method in which an explanted liver from a patient with metabolic disease is transplanted to another recipient. In cases where the liver is split and used for two recipients, the technique is termed domino split liver transplantation.</div></div><div><h3>Methods</h3><div>This study presents our experience with three pediatric DLT cases, in which liver grafts from two donor-recipient patients with maple syrup urine disease (MSUD) were transplanted to separate recipients. First donor recipient’s liver was splitted in situ, while the other was transplanted as a full-sized graft. Demographics, surgical techniques, biliary reconstruction methods, and posttransplant outcomes were analyzed.</div></div><div><h3>Results</h3><div>All recipients were discharged uneventfully following transplantation. No vascular or biliary complications were observed, and de novo MSUD did not develop in any recipient. This confirms that MSUD livers are safe for DLT, particularly in pediatric cases.</div></div><div><h3>Conclusion</h3><div>DLT using MSUD donor livers is a viable option for expanding the organ pool for pediatric transplantation. Advancements in surgical techniques and perioperative care contribute to improved patient outcomes, making DLT a valuable strategy in liver transplantation programs.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 163-168"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T Lymphocyte Reconstitution in Acute Leukemia Patients After Allogeneic Stem Cell Transplantation: A Single Center Experience (2016-2023)","authors":"Khanh Ba Nguyen ,&nbsp;Nhung Thi Hong Nguyen ,&nbsp;Binh Thi Thanh Vo ,&nbsp;Thanh Ha Nguyen","doi":"10.1016/j.transproceed.2025.11.014","DOIUrl":"10.1016/j.transproceed.2025.11.014","url":null,"abstract":"<div><h3>Introduction</h3><div>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for patients with acute myeloid leukemia. However, the success of allo-SCT is influenced by the patients' immunocompromised condition post-transplantation, particularly complications arising from infections due to prolonged immunodeficiency. This study aims to analyze the recovery of CD4+ and CD8+ T lymphocytes of patients with AML after allogeneic stem cell transplantation.</div></div><div><h3>Methods</h3><div>A retrospective study of 66 AML patients who underwent allogeneic stem cell transplantation at the National Institute of Hematology and Blood Transfusion from 2016 to 2023. The patients were monitored for immune indexes, including CD4+ and CD8+ lymphocytes, on a monthly basis for 12 months after transplantation.</div></div><div><h3>Results</h3><div>The median recovery time for CD4+ lymphocytes to reach 200 cells/μl was 84.5 ± 11.2 days, and the median time for them to reach 500 cells/μL was 8.6 months. CD8+ cells recovered faster than CD4+ cells, with a median time to reach 400 cells/μL of 64 days.</div></div><div><h3>Conclusion</h3><div>Careful monitoring of immune indicators after allo-HSCT, as demonstrated in this study, can significantly enhance prognosis and inform strategies to prevent infectious complications, particularly in patients experiencing prolonged cellular immunodeficiency. When applied, this approach could improve transplant success and reduce mortality rates, offering a deeper insight into care within hematology and transplantation.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 202-206"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole Transcriptome Sequencing Identified Potential Serum Protein Markers for the Diagnosis of Antibody Mediated Rejection Following Liver Transplantation","authors":"Yuanyi Mang ,&nbsp;Yinjia Wang ,&nbsp;Wang Li ,&nbsp;Guoyu Chen ,&nbsp;Bo Luo ,&nbsp;Gang Su ,&nbsp;Xiaohe Wu ,&nbsp;Qian Yang ,&nbsp;Ying Xie ,&nbsp;Jianghua Ran ,&nbsp;Shengning Zhang","doi":"10.1016/j.transproceed.2025.12.007","DOIUrl":"10.1016/j.transproceed.2025.12.007","url":null,"abstract":"<div><h3>Background</h3><div>Antibody medicated rejection is a challenging condition for patients undergoing liver transplantation. This study aims to investigate the mechanism of AMR and identify potential serum ma`rkers for AMR diagnosis.</div></div><div><h3>Method</h3><div>The liver tissue of 4 patients with AMR and 4 patients without AMR were collected. Whole transcriptome sequencing (RNA-seq) was performed to compare the transcriptomic alterations between the 2 groups of patients, and between tissues obtained before AMR and after AMR cure. Mass spectrometry was also performed to compare the serum proteomic changes of the 2 groups.</div></div><div><h3>Results</h3><div>Transcriptomic analysis between patients with and without AMR revealed differential expression of mRNA, lncRNA and circRNA. Analysis of differential mRNA revealed the alterations of CD and IL markers, possibly involving M1 macrophages, T cells and dendritic cells. The fold changes of mRNA levels of HLA type I and II molecules between 1.57 and 3.13 (<em>P</em> &lt; .05) suggested increased expression of HLA in all nucleated cells. In contrast, significant alterations in lncRNA and circRNA linked genes suggested comprehensive up- or down-regulations in T, B, NK cells, DCs and monocytes. Serum protein analysis between patients with or without AMR identified significant down-regulation of complement C3 (fold change: 0.63, <em>P</em> = .028), C6 (fold change: 0.72, <em>P</em> = .05), C8 (fold change: 0.67, <em>P</em> = .020), factor H (fold change: 0.54, <em>P</em> = .007), and C4-binding proteins(fold change: 0.70, <em>P</em> = .025), and significant up-regulation of HLA class I molecules(fold change: 2.53, <em>P</em> = .006), IgKappa (fold change: 2.17, <em>P</em> = .023), low-affinity IgGamma (fold change: 1,74, <em>P</em> = .024), which could be potential serum markers for AMR. Further transcriptomic analysis revealed comprehensive and unspecific alterations of immune cell levels, HLA antigen levels and cytokine expression in patients recovered from AMR following treatment, suggesting the presence of immune changes even after AMR cure.</div></div><div><h3>Conclusions</h3><div>AMR caused a wide range of changes in the cellular microenvironment in the graft liver, including cell composition, antigen expression and cytokine expression. A panel of serum protein markers related to AMR has been identified and may potentially be used for ARM diagnosis.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 151-162"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural and Religious Influences on Organ Donation Attitudes Among Indian American Physicians and Medical Students","authors":"Nandhana Vivek ,&nbsp;Niketna Vivek ,&nbsp;Roma A. Kankaria ,&nbsp;David Xiao ,&nbsp;Elisa J. Gordon ,&nbsp;Rachel Forbes","doi":"10.1016/j.transproceed.2025.12.010","DOIUrl":"10.1016/j.transproceed.2025.12.010","url":null,"abstract":"<div><h3>Purpose</h3><div>While 54% of the United States (US) population is registered as organ donors, only 0.01% of India’s population is willing to donate. Indian American physicians’ attitudes might reflect those of the general Indian-identifying US population, potentially inadvertently dissuading patients from organ donation. This study assessed whether attitudes toward organ donation differ between Indian American physicians/medical students and their non-Indian counterparts.</div></div><div><h3>Methods</h3><div>We administered an online survey to Indian American and non-Indian physicians and medical students at the American Association of Physicians of Indian Origin (AAPI) 2023 medical conference, Vanderbilt University School of Medicine, and St. Mary’s County MedStar Shah Medical Group network.</div></div><div><h3>Results</h3><div>A total of 172 individuals participated. Compared to their non-Indian counterparts, Indian American participants expressed less support for deceased (<em>p</em> = .002) and living (<em>p</em> = .006) organ donation. Hindus, constituting approximately 85% of our Indian American participants, were less supportive of deceased (<em>p</em> = .001) and living (<em>p</em> = .019) organ donation than non-Hindus. Additionally, Hindus expressed less agreement with the safety and efficacy of deceased organ donation than non-Hindus (<em>p</em> = .047). Participants who expressed concern over illegal organ trade also expressed less support for living organ donation (<em>p</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>Our study suggests different attitudes towards organ donation between physicians and medical students of Indian vs. non-Indian origin. Indian-origin individuals and Hindus demonstrated weaker support towards organ donation. Identifying these differences can help when developing targeted quality improvement initiatives in organ donation advocacy and education.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 9-14"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Mean Arterial Pressure in Relation to Delayed Graft Function in Living-Donor Kidney Transplantation","authors":"Chinnarat Pongpruksa ,&nbsp;Nutchanok Khampitak ,&nbsp;Suphamai Bunnapradist ,&nbsp;Victor W. Xia","doi":"10.1016/j.transproceed.2025.12.014","DOIUrl":"10.1016/j.transproceed.2025.12.014","url":null,"abstract":"<div><h3>Background</h3><div>Maintaining optimal kidney graft perfusion is a primary goal of intraoperative kidney transplant care, which is often monitored by mean arterial blood pressure (MAP). Delayed graft function (DGF) is a significant complication that is associated with long-term outcomes. The goal of this study is to study the association of various MAP thresholds and the risk of DGF in adult patients undergoing living-donor kidney transplant.</div></div><div><h3>Methods</h3><div>We collected data from the UCLA data warehouse between 2013 and 2024. We analyzed MAP at various thresholds and associated cumulative minutes during the pre- and postreperfusion periods. DGF, defined by dialysis within 7 days of KT, was the primary outcome.</div></div><div><h3>Results</h3><div>This study comprised 1314 patients. The DGF rate was 5.0%. Forty-two percent experienced at least 1 minute of MAP threshold at ≤60 mm Hg. Those with DGF had longer minutes spent on the MAP thresholds of ≤60 to 85. Adjusted durations of postreperfusion MAP ≤60, 65, 70, 75, 80, and 85 mm Hg associated with the DGF started from 3, 15, 20, 10, 25, and 25 minutes, in that order.</div></div><div><h3>Conclusion</h3><div>We found an association between intraoperative MAP ≤85 mm Hg and DGF. The minimal duration for postreperfusion ≤60 and ≤85 mm Hg associated with DGF was 3 and 25 minutes, respectively.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 45-51"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Donor-derived bacterial infections in deceased donor liver transplantation: reassessment of risk in the era of marginal grafts’ [Transplantation Proceedings 57(5) (2025) 823–832]","authors":"Caterina Accardo ,&nbsp;Ivan Vella ,&nbsp;Sergio LiPetri ,&nbsp;Duilio Pagano ,&nbsp;Fabrizio di Francesco ,&nbsp;Alessandra Mularoni ,&nbsp;Marco Barbàra ,&nbsp;Marco Canzonieri ,&nbsp;Paolo Grossi ,&nbsp;Salvatore Gruttadauria","doi":"10.1016/j.transproceed.2025.12.015","DOIUrl":"10.1016/j.transproceed.2025.12.015","url":null,"abstract":"","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Page 229"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness Study of Bundle Maintenance Strategies in Donor Lung Quality Improvement","authors":"Chao Wang ,&nbsp;Xue Bai ,&nbsp;Jie Lu,&nbsp;Guoqiang Qie,&nbsp;Guangyun Liu,&nbsp;Zijian Tai,&nbsp;Ruiqi Ding,&nbsp;Qianqian Guo,&nbsp;Qi Wang,&nbsp;Congcong Liu,&nbsp;Xiaoxia Sun,&nbsp;Jicheng Zhang","doi":"10.1016/j.transproceed.2025.12.004","DOIUrl":"10.1016/j.transproceed.2025.12.004","url":null,"abstract":"<div><div>To assess the efficacy of a bundle donor lung maintenance strategy in enhancing donor lung quality for transplantation. This retrospective study analyzed 155 potential lung donors admitted to Shandong Provincial Hospital (2022-2024). After excluding 76 cases meeting absolute exclusion criteria, 79 donors received a bundle maintenance protocol, including fluid management, targeted anti-infection therapy, airway care, lung-protective ventilation, and VAP prevention. Outcomes were evaluated by comparing pre- and post-maintenance oxygenation index (PaO₂/FiO₂), lactate levels, infection markers (WBC, PCT, IL-6), and transplantable lung rates. Subgroup analysis compared outcomes between prone and nonprone positioning during maintenance. Post-intervention, oxygenation index increased by 77.25% (<em>P</em> &lt; .01), with lactate reduced by 33.33% (<em>P</em> &lt; .01). Infection markers improved significantly: WBC (-16.42%), PCT (-50%), and IL-6 (-61.30%) (<em>P</em> &lt; .01). Transplantable lung rates rose from 49.37% to 87.34% (χ² = 28.03, <em>P</em> &lt; .01), converting 75% of initially nontransplantable lungs. Prone positioning further amplified benefits: ΔOI improvement (median 214 vs 148, <em>P</em> &lt; .01) and 83.33% oxygenation enhancement (<em>P</em> &lt; .01). The bundle strategy effectively optimizes donor lung quality, increasing transplantable grafts by 37.97% and demonstrating the added value of prone positioning. These findings advocate for standardized protocols to address donor shortages while ensuring transplant success.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 177-185"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Analysis of the Correlation Between Intimate Relationships and Caregiver Strain in Spouses of Kidney Transplant Recipients","authors":"Qiaoling Jiang,&nbsp;Fang Xiao,&nbsp;Hao Chen,&nbsp;Ruoyun Tan,&nbsp;Xuejing Wang,&nbsp;Ting Lu","doi":"10.1016/j.transproceed.2025.11.003","DOIUrl":"10.1016/j.transproceed.2025.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>Examine the existing dynamics of intimate relationships between kidney transplant recipients and their spouses, assess its relationship with the hardship of spousal caring, and establish a foundation for the creation of pertinent interventions to mitigate caregiving burdens.</div></div><div><h3>Methods</h3><div>A convenience sampling method was employed to select 76 pairs of recipients and spouses who were consistently monitored postkidney transplantation at a tertiary hospital in Nanjing, Jiangsu Province, China, utilizing a general information questionnaire, the Intimate Bond Measure (IBM), Lock–Wallace Marital Adjustment Test (MAT), Zarit Caregiver Burden Interview (ZBI) and Distress Thermometer (DT) for a cross-sectional study.</div></div><div><h3>Results</h3><div>The IBM scores for kidney transplant recipients and their spouses were (40.86 ± 8.05) and (41.09 ± 7.79), respectively, indicating a moderate level of marital intimacy. The MAT scores for recipients and spouses were (122.38 ± 27.08) and (121.76 ± 22.73), respectively, with 80.26% demonstrating good marital adjustment. The spouses’ total ZBI score was (19.30 ± 10.98), reflecting a mildly burdensome level. The total DT score for spouses was 3.12 ± 2.30, with 26.32% exhibiting psychological disturbances requiring further evaluation and treatment. Correlation analysis indicated a negative relationship between spousal intimacy and spousal care burden (<em>P</em> &lt; .01). Multiple linear regression analysis revealed that four variables—income level of kidney transplant recipients, duration of recipients’ illness, frequency of intimacy behaviors, and degree of spousal psychological distress—were included in the regression equation, collectively accounting for 77.9% of the total variance in spousal care burden (<em>P</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>The intimacy between spouses in kidney transplant recipients is inversely related to the stress of caregiving experienced by the spouse. Healthcare professionals should underscore the beneficial role of spouses in therapeutic care, implementing strategies to enhance spousal intimacy and alleviate caregiving burdens, thereby improving the quality of spousal care and the survival outcomes of kidney transplant recipients.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 37-44"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}