Thermal Medicine最新文献

{"title":"Role of Hyperthermia in the Treatment of Gastrointestinal Cancers","authors":"Takeo Takahashi, J. Saitoh, N. Okonogi, A. Okazaki","doi":"10.3191/THERMALMED.29.25","DOIUrl":"https://doi.org/10.3191/THERMALMED.29.25","url":null,"abstract":"Gastointestinal cancers continue to be a common health problem. Among gastrointestinal cancers,gastric and colorectal cancers are most common causes of cancer incidence and death worldwide. These are basically treated surgically,but multidisciplinary treatment is applied for locally advanced and recurrent cancers,and its main modality is chemoradiotherapy(CRT). Preoperative CRT is performed for locally advanced rectal cancer. On the other hand,postoperative CRT is viewed by many reports as the standard care for advanced stomach cancer in Western countries. Curative or preoperative CRT is a standard treatment for locally advanced esophageal cancer. There have been several reports on the combination of these with regional hyperthermia in which favorable therapeutic outcomes were achieved. Regarding hyperthermia, thermal enhancement by combination with radiation and various anticancer drugs has been reported in vitro and in vivo. Particularly,thermal enhancement by combination with novel anticancer drugs may lead to further improvement of the therapeutic outcome. For peritoneal dissemination of gastrointestinal cancers including stomach cancer, hyperthermic intraperitoneal chemotherapy has been shown to be effective,as expected. There is also a possibility of the combination of hyperthermia with immunotherapy. It is necessary to elucidate the mechanism of thermal enhancement and demonstrate the efficacy of hyperthermia by performing an appropriate clinical study.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80858638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Strategies for Ultrasound Diagnostics and Therapeutics by Micro/Nanobubbles","authors":"R. Suzuki, Y. Oda, D. Omata, Y. Sawaguchi, M. Seki, Hitoshi Uruga, Tomoyuki Naoi, Y. Negishi, K. Maruyama","doi":"10.3191/THERMALMED.29.37","DOIUrl":"https://doi.org/10.3191/THERMALMED.29.37","url":null,"abstract":"Theranostics is a novel concept that combines diagnostics and therapeutics. In the field of diagnostics, various pieces of medical equipment are commonly used, such as X-ray computed tomography,magnetic resonance imaging,positron emission tomography,and sonography. Because of physical energy within these different pieces of equipment,ultrasound is a useful tool for theranostics,and it is particularly suitable for diagnostics with sonography and therapeutics with hyperthermia for cancer. Recently,microbubbles were recognized as an effective type of agent for imaging blood flow in tumors. In particular,Sonazoid,which is a commercially available microbubble,has been used for detection of hepatic tumors. In addition,microbubbles are useful tools for theranostics because they can be used not only as an ultrasound contrast imaging agent but also as an enhancer for hyperthermia with therapeutic ultrasound. To improve the accessibility of microbubbles in the deep tissue,researchers are developing various types of smaller bubbles such as the submicron-sized nanobubble. We have also developed novel liposomal bubbles(Bubble liposomes),which consist of entrapped perfluoropropane gas in a lipid bilayer. Bubble liposomes have several advantages over existing technologies,such as they can be used as ultrasound imaging agents,it is easy to modify the targeting molecules on their surfaces,and they are highly applicable for the enhancement of hyperthermia with therapeutic ultrasound. In summary,the combination of ultrasound and micro/nanobubbles would allow for the development of an ideal method for noninvasive theranostics. In this review, we will introduce recent developments on ultrasound theranostics using microbubbles and nanobubbles such as Bubble liposomes.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75222773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Solutions in Oncological Hyperthermia","authors":"A. Szász","doi":"10.3191/THERMALMED.29.1","DOIUrl":"https://doi.org/10.3191/THERMALMED.29.1","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80859793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can be Heat Shock Transcription Factor 1 a Potential Target for Hyperthermic Therapy","authors":"Y. Tabuchi","doi":"10.3191/THERMALMED.28.63","DOIUrl":"https://doi.org/10.3191/THERMALMED.28.63","url":null,"abstract":"Hyperthermia(HT)has been considered a promising approach in cancer therapy. However, the acquisition of thermoresistance in tumor due to several responses of tumor,such as an increase in heat shock proteins (HSPs),makes HT less effective. The induction of HSPs is mainly mediated by the activation of heat shock transcription factor 1 (HSF1). It has been shown that HSF1 is abundantly expressed in human tumor cells of various origins. Moreover, it takes part in the initiation and maintenance of tumor. Silencing of HSF1 could suppress tumor formation and enhance the effectiveness of HT. In this review,the physiological and pathological roles of HSF1 in cancer cells are summarized, and its potential as a therapeutic target for hyperthermic therapy is discussed.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80851844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Noninvasive Magnetic Resonance Temperature Imaging of Fat and Water Based on Methylene Proton Spin-lattice Relaxation Time and Water Proton Resonance Frequency","authors":"K. Kuroda, Shuhei Morita, M. K. Lam, M. Obara, P. Baron, W. Bartels, Masatoshi Honda, T. Horie, Y. Imai","doi":"10.3191/THERMALMED.28.87","DOIUrl":"https://doi.org/10.3191/THERMALMED.28.87","url":null,"abstract":":A noninvasive magnetic resonance temperature imaging technique for fat-water mixed tissues was proposed. This technique uses the temperature dependence of the spin-lattice relaxation time( T (cid:50876) ) of protons originated from methylene chain(CH (cid:50877) )of fat as well as the resonance frequency shift of water proton(H (cid:50877) O). A multiple point Dixon method in conjunction with a multiple flip angle method enables simultaneous calculation of T (cid:50876) of CH (cid:50877) and the resonance frequency change of H (cid:50877) O. A phantom with two mayonnaise tubes,one heated by microwave while the other kept at room temperature was imaged at 3 Tesla during the cooling process by a spoiled gradient recalled acquisition in steady state (SPGR)of the following conditions;field of view,32 × 32 cm (cid:50892) ;matrix,64 × 64;parallel imaging factor, 2;repetition time,36 ms;echo time spacing,1.15 ms;and flip angles,20,50 and 70 degrees. Signals obtained with each flip angle were processed by IDEAL(Iterative Decomposition of water and fat with Echo Asymmetry and Least squares estimation)algorithm to obtain H (cid:50877) O,CH (cid:50877) and CH (cid:50878) images. The smaller components of fat were ignored for simplicity. Temperature distribution of fat in the phantom was imaged by T (cid:50876) of CH (cid:50877) obtained from the three CH (cid:50877) images with different flip angles,while that of water with the change in the phase difference between H (cid:50877) O and CH (cid:50877) or the relative phase change in H (cid:50877) O. Those temperature images were then fused as a weighted sum of H (cid:50877) O and CH (cid:50877) fractions in each voxel. The resultant images highly correlated with the probe-measured temperature elevation demonstrating that simultaneous fat-water temperature imaging is feasible and is expected to be sufficient for clinical practice. . The other study evaluated the stability of the water-fat chemical shifts using line scan echo planar spectroscopic imaging(LSEPSI) (cid:50896)(cid:50903) . The deviation of the results demonstrated that the water-fat PRF difference is not a useful indicator for breast temperature. Moreover,both water and fat contents have to be high enough in this type of spectroscopic technique. These studies were conducted at relatively low magnetic field(0.5-1.5T)aiming at observation of total fat signal without separating the fatty acid components.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87304489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Expression Analysis of Heat Shock Protein A Family Members Responsive to Hyperthermic Treatments in Normal Human Fibroblastic Cells","authors":"Tatsuya Yunoki, Ayako Kariya, T. Kondo, A. Hayashi, Y. Tabuchi","doi":"10.3191/THERMALMED.28.73","DOIUrl":"https://doi.org/10.3191/THERMALMED.28.73","url":null,"abstract":"Heat shock protein A (HSPA)family members consist of at least 13 genes. We studied the effects of heat stress on the gene expression of HSPA family members in normal human fibroblastic (NHF) cells. Four NHF cell lines, Hs68, OUMS-36, NTI-4, and KD, were treated with mild hyperthermia(MHT)at 41°C for 30 min or hyperthermia(HT)at 43°C for 30 min,followed by culturing for 1 or 24 h at 37°C.Treatment of cells with HT significantly induced cell death,whereas this change was not observed in cells treated with MHT. Real-time quantitative polymerase chain reaction demonstrated that the expression levels of HSPA1A,HSPA1B,HSPA1L,HSPA4,HSPA4L,HSPA5 and HSPA6 were significantly elevated in the cells treated with MHT and HT,and the HT treatment was more effective than the MHT treatment. This report is the first to describe an increase in HSPA4 expression by heat treatment. These alterations were observed in all four NHF cell lines in the same way. On the other hand, neither MHT nor HT affected the expression levels of HSPA2, HSPA8, HSPA9, HSPA12A, HSPA13 and HSPA14. These results demonstrated that HSPA1A, HSPA1B, HSPA1L, HSPA4, HSPA4L, HSPA5 and HSPA6 were heat-inducible HSPA genes, but the remaining HSPA family members were constitutive(not heat-inducible)HSPA genes. Under the non-heated condition at 37°C, the expression levels of constitutive HSPA genes were higher than those of heat-inducible HSPA genes. In conclusion,the gene expression patterns of HSPA family members responsive to heat stresses in NHF cells were identified. These results may provide a basis for understanding the molecular mechanisms of MHT and HT in normal cells.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74333659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Biliary Stent Compatible with Microwave Hyperthermia for Bile Duct Carcinoma","authors":"H. Itakura, Kazuyuki Saito, Masaharu Takahashi, K. Ito","doi":"10.3191/THERMALMED.28.43","DOIUrl":"https://doi.org/10.3191/THERMALMED.28.43","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88099400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"進行口腔癌の頸部リンパ節転移（N2, 3）に対する逆行性超選択的動注法を用いた温熱化学放射線療法","authors":"Kenji Mitsudo, T. Koizumi, M. Iida, Sachiyo Mitsunaga, I. Tohnai","doi":"10.3191/THERMALMED.28.23","DOIUrl":"https://doi.org/10.3191/THERMALMED.28.23","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73430580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hsp90 Inhibitors are Promising Radiosensitizers for Radiotherapy","authors":"N. Kubota, Y. Matsumoto","doi":"10.3191/THERMALMED.28.53","DOIUrl":"https://doi.org/10.3191/THERMALMED.28.53","url":null,"abstract":"Heat shock protein 90(Hsp90)is an ATP-dependent molecular chaperone protein.The Hsp90 superchaperone complex assists folding and function of a variety of client proteins.Many oncoproteins are Hsp90 client proteins.Compared to normal cels,tumor cels require higher Hsp90 chaperone activity;therefore,targeting Hsp90 with chemical inhibitors disrupts multiple oncogenic processes and has potent antitumor activity.Many Hsp90 inhibitors are currently being tested in preclinical or clinical trials.This review summarizes published data concerning radiosensitization of human tumor cels in in vitro and in vivo tumor models with Hsp90 inhibitors.","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79672517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperthermia Enhances Immunotherapy in Cancer Patients","authors":"T. Takeda, Tohru Takahashi, I. Yamamoto, T. Hasegawa, T. Takeda, H. Takeda","doi":"10.3191/THERMALMED.28.11","DOIUrl":"https://doi.org/10.3191/THERMALMED.28.11","url":null,"abstract":"","PeriodicalId":23299,"journal":{"name":"Thermal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75997363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}