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Benzimidazole‐associated pancytopenia in a dog with presumed Heterobilharzia americana infection 一只推测感染了美洲杂环虫的狗出现苯并咪唑相关的泛血细胞减少症
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-09 DOI: 10.1002/vrc2.892
Kyle L. Granger, Charles T. Talbot, Cory N. Wakamatsu, McAllister Harris, Kristy L. Dowers
Adverse drug events are classified into type A (dose‐dependent and common) or type B (idiosyncratic and uncommon) reactions. Benzimidazole toxicosis in veterinary medicine typically induces nonspecific signs such as gastrointestinal distress and infrequent myelosuppression. Pancytopenia from benzimidazoles is exceptionally rare, with only one reported case. We present a 12‐year‐old, female, spayed, mixed‐breed dog with acute lethargy, anorexia, pyrexia and severe leukopenia after high‐dose benzimidazole therapy for suspected liver fluke infection. Despite hospitalisation, the dog remained unresponsive to antimicrobial therapies, developed neutropenic sepsis and was euthanized. Bone marrow analysis indicated marked haematopoietic hypoplasia suggestive of a type A adverse drug event secondary to an incidental, high‐dose fenbendazole administration.
药物不良反应可分为A型(剂量依赖性和常见)和B型(特异性和不常见)。在兽医领域,苯并咪唑中毒通常会引起非特异性症状,如胃肠道不适和不常见的骨髓抑制。苯并咪唑类药物引起的全血细胞减少症异常罕见,仅有一例报道。我们介绍的是一只 12 岁的雌性混血犬,因怀疑感染肝吸虫而接受大剂量苯并咪唑治疗后出现急性嗜睡、厌食、热病和严重白细胞减少症。尽管住院治疗,但该犬对抗菌疗法仍无反应,出现了中性败血症并被安乐术。骨髓分析显示,该犬出现明显的造血功能减退,这表明该犬因意外服用大剂量芬苯达唑而继发了A型药物不良事件。
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引用次数: 0
Management of bilateral lower eyelid entropion in a black Angus bull by temporary tacking and modified Hotz Celsus 用临时粘贴法和改良的 Hotz Celsus 法治疗一头黑色安格斯公牛的双侧下眼睑内翻
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-08 DOI: 10.1002/vrc2.890
Leila Bedos, Anna Catherine Bowden, Jeff Olivarez, Melissa A. Kubai, Rachel A. Allbaugh
The objective was to evaluate the progression and management of eyelid tacking sutures before permanent eyelid surgical correction. A 1‐year‐old Aberdeen black Angus bull presented with a 1‐month history of bilateral corneal ulcers. Ophthalmic examination revealed an infected stromal corneal ulcer on the left eye and bilateral lower eyelid entropion. Lower eyelid tacking sutures were placed bilaterally to allow corneal healing, prevent recurrent corneal ulceration and allow resolution of concurrent moist dermatitis. Approximately 2 weeks after eyelid tacking, permanent entropion repair using a modified Hotz Celsus technique was performed on both lower eyelids. This report details the successful treatment of bilateral lower eyelid entropion in a bull using temporary tacking sutures to stabilise corneal and eyelid disease before permanent eyelid surgical correction.
目的是评估永久性眼睑手术矫正前眼睑粘连缝合的进展和管理。一头 1 岁大的阿伯丁黑安格斯公牛在 1 个月前出现双侧角膜溃疡。眼科检查发现左眼角膜基质溃疡感染,双侧下眼睑内翻。为了让角膜愈合,防止角膜溃疡复发,并缓解并发的湿疹,医生对双侧患者进行了下眼睑粘连缝合。眼睑粘连约两周后,采用改良的 Hotz Celsus 技术对双侧下眼睑进行永久性内翻修复。本报告详细介绍了在对公牛进行永久性眼睑手术矫正之前,使用临时粘合缝合线稳定角膜和眼睑疾病的方法,成功治疗了公牛的双侧下眼睑内翻。
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引用次数: 0
Klebsiella spp.‐associated septicaemia in a 5‐day‐old reindeer (Rangifer tarandus) calf 一头 5 天大的驯鹿(Rangifer tarandus)幼崽患的克雷伯氏菌属相关败血症
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-08 DOI: 10.1002/vrc2.874
Daniel Prado, Joseph Smith, Taylor Locklear, Denae LoBato, Michelle Liu
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引用次数: 0
Oesophageal haematoma in a Cairn terrier presenting for impaired swallowing, retching and cervical pain 一只凯恩梗犬因吞咽困难、反胃和颈椎疼痛而出现食道血肿
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-07 DOI: 10.1002/vrc2.876
Carley Johnson, Janis Lapsley, Hunter Piegols, Adam Rudinsky, Laura E. Selmic
A 13‐year‐old spayed female Cairn terrier was referred for surgical resection of a large oesophageal mass. The dog was initially presented to the primary care veterinarian for several days of gagging. The mass was initially diagnosed on thoracic radiographs and confirmed via computed tomography and oesophagoscopy. Endoscopic biopsies were performed that were consistent with oesophagitis. The dog was then referred to The Ohio State University Veterinary Medical Center for surgical resection of the mass. On surgical approach, a small nodule was palpable in the oesophagus; however, a large mass was not found. Oesophagoscopy was repeated intraoperatively, which revealed a small nodule in the same region of the previously described mass. The small nodule was removed, and histopathology was consistent with lymphohistiocytic inflammation and previous haemorrhage, consistent with an oesophageal haematoma. The dog made a full recovery post‐operatively, with continued resolution of clinical signs reported 5 months after surgery.
患者是一只 13 岁的绝育雌性凯恩梗,因食道大肿块而转诊接受手术切除。该犬最初因连续几天吞咽困难而被送往主治兽医处。该肿块最初是通过胸部 X 光片诊断出来的,后经计算机断层扫描和食道镜检查证实。内窥镜活检结果与食道炎一致。随后,该犬被转到俄亥俄州立大学兽医中心进行肿块手术切除。手术时,在食道内可触及一个小结节,但未发现大肿块。术中再次进行食道镜检查,发现在之前描述的肿块的同一区域有一个小结节。切除了小结节,组织病理学检查结果与淋巴组织细胞炎症和先前的出血一致,与食道血肿相符。该犬术后完全康复,据报告术后 5 个月临床症状持续缓解。
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引用次数: 0
Total mastectomy in severe necrotic mastitis in a pet goat complicated by a post‐operative generalised emphysema 宠物山羊严重坏死性乳腺炎并发术后全身气肿时的全乳房切除术
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-06 DOI: 10.1002/vrc2.889
Rok Marzel, Starič Jože, Veren Geč Lena, Klinc Primož
A total mastectomy was the treatment of choice in a 10‐year‐old pet doe Pika with a history of severe necrotic mastitis secondary to a precocious udder. Following an elliptical skin incision, the mammary tissue was bluntly excised. Because of a large surgical defect, severe skin tension was needed to close the wound completely. A passive drain was placed in the surgical site to remove excess fluid, and the animal received antibiotic and anti‐inflammatory treatment. On the fifth day after the surgery, the drain was removed and palpation revealed an extensive subcutaneous emphysema at the surgical site as well as the back and neck of the animal. The antibiotic treatment was prolonged, and the animal kept for observation. After 3 weeks, the wound had healed completely, and the doe was discharged.
一只 10 岁的宠物母鹿皮卡因乳房早熟而继发严重的坏死性乳腺炎,它的首选治疗方法是全乳房切除术。在椭圆形皮肤切口后,乳腺组织被钝性切除。由于手术缺损较大,需要施加很大的皮肤张力才能完全闭合伤口。在手术部位放置了一个被动引流管,以清除多余的液体,并对动物进行了抗生素和消炎治疗。术后第五天,引流管被移除,触诊发现手术部位以及动物的背部和颈部出现了广泛的皮下气肿。医生延长了抗生素治疗时间,并继续观察该动物。3 周后,伤口完全愈合,母鹿出院。
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引用次数: 0
Hypercalcaemia in a dog with hypothyroidism 甲状腺功能减退症患犬的高钙血症
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-05 DOI: 10.1002/vrc2.845
Erika Brandeker, Amanda Scuka, Josefine Öberg
A 5‐year‐old, entire, female Greenland dog was presented with polyuria and polydipsia. A mildly increased circulating concentration of ionised calcium, mild non‐regenerative anaemia, mild hypercholesterolemia and mild increases in liver enzyme activity were detected. Parathyroid hormone, plasma parathyroid hormone‐related protein and vitamin D were analysed in a blood sample, with all results below the lower limit of the reference range. Further investigation with abdominal ultrasonography, fine‐needle aspiration for cytology of the liver and spleen, thoracic radiography, adrenocorticotropic hormone‐stimulation and serum protein electrophoresis could not detect any disease. During the next months, the dog developed coat changes that clinically corresponded to an endocrinopathy. Analysis of thyroxine and thyroid‐stimulating hormone was performed. Thyroxine was less than 6 nmol/L and thyroid‐stimulating hormone was 1.5 µg/L, which indicated primary hypothyroidism. Treatment with l‐thyroxine resulted in normalisation of the hypercalcaemia. Moreover, the polyuria and alopecia resolved.
一只 5 岁大的雌性格陵兰犬出现多尿和多饮症状。经检测,该犬血液循环中的离子化钙浓度轻度升高、轻度非再生性贫血、轻度高胆固醇血症和肝酶活性轻度升高。对血样中的甲状旁腺激素、血浆甲状旁腺激素相关蛋白和维生素 D 进行了分析,所有结果均低于参考范围的下限。进一步的检查包括腹部超声波检查、肝脏和脾脏细针穿刺细胞学检查、胸部放射线检查、促肾上腺皮质激素刺激检查和血清蛋白电泳检查,均未发现任何疾病。在接下来的几个月里,这只狗的皮毛发生了变化,临床表现与内分泌病症相符。对甲状腺素和促甲状腺激素进行了分析。甲状腺素低于 6 nmol/L,促甲状腺激素为 1.5 µg/L,这表明狗狗患有原发性甲状腺功能减退症。使用左旋甲状腺素治疗后,高钙血症恢复正常。此外,多尿症和脱发也得到了缓解。
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引用次数: 0
Type I congenital elbow luxation treated by radial head ostectomy in four dogs (2019–2021) 通过桡骨头切除术治疗四只狗的 I 型先天性肘关节松弛症 (2019-2021)
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-05 DOI: 10.1002/vrc2.865
Laura Bondonny, Audrey Belmudes, Pablo Rivier
Four dogs with a median age of 5 months (4–8 months) were presented with type I congenital elbow luxation. Two dogs were bilaterally affected. All dogs had severe lameness and limited range of motion of the affected elbow. All were treated by radial head ostectomy. Mid‐term results were assessed by clinical and radiographic or computed tomography follow‐up in three dogs and using a validated owner questionnaire, the canine brief pain inventory (CBPI), in all dogs. Long‐term follow‐up was continued using the same questionnaire over a median time of 40.5 months. Follow‐up computed tomography or radiographs showed persistent humeroulnar incongruency and bone proliferation proximal to the ostectomy site. All owners reported rare episodes of mild lameness and a decreased CBPI score. This therapeutic option provided satisfactory mid‐ and long‐term outcomes. Moreover, to our knowledge, this is the first report of bilateral radial head ostectomy in dogs with type I congenital elbow luxation.
四只狗的中位年龄为5个月(4-8个月),患有I型先天性肘关节脱位。其中两只狗双侧受累。所有患犬都严重跛行,患肘活动范围受限。所有病犬都接受了桡骨头切除术。对三只狗进行了临床和放射线或计算机断层扫描随访,并使用经过验证的狗主问卷--犬简短疼痛清单(CBPI)--对所有狗进行了中期结果评估。使用相同的问卷继续进行长期随访,中位随访时间为 40.5 个月。随访的计算机断层扫描或X光片显示,肱骨与桡骨不协调和骨质增生在骨切除术部位的近端持续存在。所有马主都报告说,他们的马很少出现轻微跛行,CBPI评分也有所下降。这种治疗方法的中长期疗效令人满意。此外,据我们所知,这是第一份对患有I型先天性肘关节脱位的狗进行双侧桡骨头骨切除术的报告。
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引用次数: 0
Diagnosis and treatment of metastatic uterine lymphoma in a chinchilla (Chinchilla lanigera) 龙猫(Chinchilla lanigera)转移性子宫淋巴瘤的诊断和治疗
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-03 DOI: 10.1002/vrc2.886
Alicia McLaughlin, Chelsea Tripp, Eric Hostnik, Anna‐Maria Travis, Elise LaDouceur
A 4‐year‐old, entire, female chinchilla (Chinchilla lanigera) presented to an emergency veterinary hospital for laboured breathing, lethargy and hyporexia. Physical exam findings and diagnostic imaging were supportive of uterine disease. An ovariohysterectomy was performed, and histopathology diagnosed incompletely resected uterine lymphoma. A rotating outpatient chemotherapy protocol containing oral prednisolone (0.5 mg/kg), subcutaneous L‐asparaginase (400 iu/kg), oral cyclophosphamide (200 mg/m2) and subcutaneous cytosine arabinoside (50 mg/kg) was initiated. The patient tolerated chemotherapeutics well based on normal behaviour, appetite, exam findings and serial bloodwork values. One hundred two days after initial presentation, the patient was euthanased due to a decline in clinical condition. Postmortem examination and histopathology confirmed metastasis of lymphoma to the brain, mediastinum, mesentery, liver and spleen. No evidence of organ damage due to chemotherapeutics was noted histologically. Postmortem immunohistochemistry confirmed the diagnosis of lymphoma. Further studies are needed to guide chemotherapeutic dosing and treatment of lymphoma in chinchillas.
一只 4 岁大的整只雌性龙猫(Chinchilla lanigera)因呼吸困难、嗜睡和厌食症前往一家急诊兽医院就诊。体格检查结果和影像诊断结果均支持子宫疾病。医生为它进行了卵巢切除术,组织病理学诊断为未完全切除的子宫淋巴瘤。患者开始接受门诊轮换化疗方案,包括口服泼尼松龙(0.5 mg/kg)、皮下注射L-天冬酰胺酶(400 iu/kg)、口服环磷酰胺(200 mg/m2)和皮下注射阿糖胞苷(50 mg/kg)。患者的行为、食欲、检查结果和连续血检值均正常,化疗耐受性良好。初次发病 120 天后,患者因临床状况恶化而被安乐死。尸检和组织病理学证实淋巴瘤转移到了大脑、纵隔、肠系膜、肝脏和脾脏。组织病理学上没有发现化疗导致器官损伤的证据。死后免疫组化证实了淋巴瘤的诊断。要指导龙猫淋巴瘤的化疗剂量和治疗,还需要进一步的研究。
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引用次数: 0
Bilateral renal dysplasia in a ferret (Mustela putorius furo) 雪貂(Mustela putorius furo)双侧肾发育不良
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-02 DOI: 10.1002/vrc2.887
Sayrah Gilbert, Angela Lennox, Cathy Johnson‐Delaney, Ethan Biswell
Renal dysplasia is a histological diagnosis characterised by disorganised architecture of the renal cortex and medulla with disrupted nephron differentiation and primitive ducts surrounded by collarettes of the mesenchymal tissue. This condition has been reported once previously in ferrets as a component of multiple congenital abnormalities of the urogenital tract. A 1.5‐year‐old, male, neutered ferret was presented after being found minimally responsive under a fallen shelf in its enclosure. The ferret was obtunded, with mild intermittent muscle tremors and severe dehydration. Survey radiographs, including thoracic and abdominal ventrodorsal and right and left lateral views, were performed to assess for general trauma. The right renal silhouette was normal in size, and the left was moderately reduced. The capsular margins of both renal silhouettes were moderately undulating and mildly indistinct with perirenal retroperitoneal striations. No signs of trauma or other abnormalities were identified. Whole blood biochemical analysis demonstrated elevated creatinine, elevated blood urea nitrogen, hypernatraemia, hypercalcaemia, hyperphosphataemia and hyperproteinemia characterised by hyperalbuminemia and haemoconcentration. The hypernatraemia and mentation failed to improve with intravenous fluid therapy, and the ferret was euthanased. Bilateral renal dysplasia was confirmed via gross postmortem examination and histopathology.
肾发育不良是一种组织学诊断,其特征是肾皮质和髓质结构混乱,肾小球分化紊乱,原始导管被间质组织的袢包围。此前曾有报道称,这种病症是雪貂泌尿生殖道多发性先天性畸形的一个组成部分。一只 1.5 岁的雄性绝育雪貂被发现在围栏中倒下的架子下,反应微弱。雪貂昏迷不醒,肌肉间歇性轻微颤抖,严重脱水。为评估其全身创伤情况,对其进行了胸部和腹部腹背和左右侧视等检查。右侧肾轮廓大小正常,左侧肾轮廓中度缩小。两个肾脏轮廓的囊状边缘呈中度起伏,肾周腹膜后条纹轻度模糊。未发现外伤或其他异常迹象。全血生化分析显示肌酐升高、血尿素氮升高、高钠血症、高钙血症、高磷血症和高蛋白血症,并伴有高白蛋白血症和血液浓缩。经静脉输液治疗后,高钠血症和精神症状未能改善,雪貂被安乐术。通过尸体大体检查和组织病理学检查,确认了双侧肾脏发育不良。
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引用次数: 0
Dynamic intramedullary crosspinning technique for the treatment of distal femoral metaphyseal fracture in a free‐ranging jaguarundi (Herpailurus yagouaroundi) 用动态髓内交叉针技术治疗散养美洲豹(Herpailurus yagouaroundi)股骨远端骨骺骨折
IF 0.3 Q4 VETERINARY SCIENCES Pub Date : 2024-05-02 DOI: 10.1002/vrc2.879
Guilherme Rech Cassanego, Sheila Canevese Rahal, Marcelo Meller Alievi, Charline Vanessa Vaccarin, Gabriella De Nardin Peixoto
An approximately 3‐month‐old female free‐ranging jaguarundi (Herpailurus yagouaroundi) was admitted for evaluation of swelling near the right stifle and inability to use the right hindlimb. Radiographic examination revealed a closed, short oblique fracture of the right distal femoral metaphysis, and the bone cortex appeared thin. Because of the poor body condition, the surgical procedure was performed 6 days after admission. The fracture was stabilised using a dynamic intramedullary crosspinning technique. Two 1.5 mm diameter Kirschner (K) wires were introduced at an approximately 20° angle to the sagittal plane of the femur. Radiographic evaluation 3 months after surgery revealed an open distal physis, fracture healing in the remodelling phase and K‐wires engulfed by the bone, which made removal impossible. At the 6‐month follow‐up, a length discrepancy of 0.8 cm in the right femur compared to the left femur was noted. Despite this complication, the locomotion pattern was considered normal according to visual gait analysis.
一只约 3 个月大的雌性自由放养美洲豹(Herpailurus yagouaroundi)因右跗骨附近肿胀和无法使用右后肢而入院。影像学检查显示,它的右股骨远端干骺端有一处闭合性短斜骨折,骨皮质较薄。由于身体状况不佳,手术在入院 6 天后进行。采用动态髓内交叉钉技术稳定了骨折。两根直径为1.5毫米的Kirschner(K)导线与股骨矢状面成约20°角。术后3个月的X光片评估显示,患者的远端骨骺呈开放状态,骨折愈合处于重塑阶段,K线被骨质吞噬,无法取出。在 6 个月的随访中,发现右侧股骨的长度与左侧股骨相比有 0.8 厘米的差距。尽管出现了这种并发症,但根据视觉步态分析,患者的运动模式被认为是正常的。
{"title":"Dynamic intramedullary crosspinning technique for the treatment of distal femoral metaphyseal fracture in a free‐ranging jaguarundi (Herpailurus yagouaroundi)","authors":"Guilherme Rech Cassanego, Sheila Canevese Rahal, Marcelo Meller Alievi, Charline Vanessa Vaccarin, Gabriella De Nardin Peixoto","doi":"10.1002/vrc2.879","DOIUrl":"https://doi.org/10.1002/vrc2.879","url":null,"abstract":"An approximately 3‐month‐old female free‐ranging jaguarundi (<jats:italic>Herpailurus yagouaroundi</jats:italic>) was admitted for evaluation of swelling near the right stifle and inability to use the right hindlimb. Radiographic examination revealed a closed, short oblique fracture of the right distal femoral metaphysis, and the bone cortex appeared thin. Because of the poor body condition, the surgical procedure was performed 6 days after admission. The fracture was stabilised using a dynamic intramedullary crosspinning technique. Two 1.5 mm diameter Kirschner (K) wires were introduced at an approximately 20° angle to the sagittal plane of the femur. Radiographic evaluation 3 months after surgery revealed an open distal physis, fracture healing in the remodelling phase and K‐wires engulfed by the bone, which made removal impossible. At the 6‐month follow‐up, a length discrepancy of 0.8 cm in the right femur compared to the left femur was noted. Despite this complication, the locomotion pattern was considered normal according to visual gait analysis.","PeriodicalId":23496,"journal":{"name":"Veterinary Record Case Reports","volume":"11 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Veterinary Record Case Reports
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