{"title":"Evaluation of The Relationship of Necrotizing Enterocolitis and Mortality in Premature Babies","authors":"I. Deger, S. Ertuğrul, İ. Yolbaş","doi":"10.5505/vtd.2022.48343","DOIUrl":"https://doi.org/10.5505/vtd.2022.48343","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76177479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant Hypertension","authors":"H. Akın, Ö. Bilge","doi":"10.5505/vtd.2022.89090","DOIUrl":"https://doi.org/10.5505/vtd.2022.89090","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74146268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship Between Loneliness and Perceived Social Support Levels in Oncology Patients","authors":"A. Arslan, Makbule Batmaz, Havva Gezgİn Yazici","doi":"10.5505/vtd.2022.26529","DOIUrl":"https://doi.org/10.5505/vtd.2022.26529","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73327089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ş. Külahçıoğlu, Kadir Bıyıklı, D. Çeneli, S. Tanyeri, B. Kültürsay, B. Keskin, Okan Korun, E. Cakmak, Enver Yücel, A. Karagoz, I. Tanboğa, C. Kaymaz
{"title":"Evaluation of the Relationship Between Eosinophil to Monocyte Ratio and Ieft Ventricle Ejection Fraction in Patients With Acute Coronary Syndrome","authors":"Ş. Külahçıoğlu, Kadir Bıyıklı, D. Çeneli, S. Tanyeri, B. Kültürsay, B. Keskin, Okan Korun, E. Cakmak, Enver Yücel, A. Karagoz, I. Tanboğa, C. Kaymaz","doi":"10.5505/vtd.2022.18199","DOIUrl":"https://doi.org/10.5505/vtd.2022.18199","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72838213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic Significance of Ratio of Metastatic Lymph Nodes in Colorectal Cancer Patients Treated with Curative Resection","authors":"K. Gülben, O. Uyar, B. Öndeş","doi":"10.5505/vtd.2022.24855","DOIUrl":"https://doi.org/10.5505/vtd.2022.24855","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82552497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lysosomes are organelles that break down damaged components or structures that have completed their task in the cell by the hydrolytic enzymes they contain and take part in the last step of the autophagic pathway. Autophagy, an evolutionarily conserved lysosomal pathway, is activated under stress conditions such as amino acid starvation, accumulation of unfolded proteins, or viral infection. The main task of autophagy is to remove damaged proteins, organelles and microorganisms that constitute the source of infection. During this degradation mechanism, autophagosomes are formed as a result of the interaction of lysosomes and autophagic vesicles carrying damaged proteins, and this formation is tightly controlled by cellular mechanisms. Damage during this interaction can disrupt cellular homeostasis and interfere with the survival of the organism. Lysosomal Storage Diseases (LDH) is one of the most common human genetic diseases that develop because of mutations on genes encoding lysosomal enzymes. To date, more than 70 LDHs have been identified. LDH is mainly caused by functional disorders of enzymes or lysosome-associated proteins in lysosomes. These disorders may cause undigested macromolecules to accumulate in the cells, compromising the proper functioning of the organs in which they are located. LDH can cause many systemic damages, especially in the nervous system, skeletal system, and reticuloendothelial system, especially in the early stages of the disease. Modulation and reactivation of autophagy is considered a new therapeutic approach for LDH. In this review, the general mechanisms of the relationship between lysosomal storage diseases and autophagy were evaluated together with treatment approaches.
{"title":"Relationship of Lysosomal Storage Diseases (LSD) with Autophagy","authors":"S. Keskin, I. Alkac, B. Çerçi","doi":"10.5505/vtd.2022.95776","DOIUrl":"https://doi.org/10.5505/vtd.2022.95776","url":null,"abstract":"Lysosomes are organelles that break down damaged components or structures that have completed their task in the cell by the hydrolytic enzymes they contain and take part in the last step of the autophagic pathway. Autophagy, an evolutionarily conserved lysosomal pathway, is activated under stress conditions such as amino acid starvation, accumulation of unfolded proteins, or viral infection. The main task of autophagy is to remove damaged proteins, organelles and microorganisms that constitute the source of infection. During this degradation mechanism, autophagosomes are formed as a result of the interaction of lysosomes and autophagic vesicles carrying damaged proteins, and this formation is tightly controlled by cellular mechanisms. Damage during this interaction can disrupt cellular homeostasis and interfere with the survival of the organism. Lysosomal Storage Diseases (LDH) is one of the most common human genetic diseases that develop because of mutations on genes encoding lysosomal enzymes. To date, more than 70 LDHs have been identified. LDH is mainly caused by functional disorders of enzymes or lysosome-associated proteins in lysosomes. These disorders may cause undigested macromolecules to accumulate in the cells, compromising the proper functioning of the organs in which they are located. LDH can cause many systemic damages, especially in the nervous system, skeletal system, and reticuloendothelial system, especially in the early stages of the disease. Modulation and reactivation of autophagy is considered a new therapeutic approach for LDH. In this review, the general mechanisms of the relationship between lysosomal storage diseases and autophagy were evaluated together with treatment approaches.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79467044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duran Topak, Mustafa Özdemir, F. Doğar, Kadir İsmail Dere, Halil Mutlu, Ökkeş Bilal
{"title":"Can Titanium Elastic Nails be the First Treatment Choice in Pediatric Femoral Shaft Fractures?","authors":"Duran Topak, Mustafa Özdemir, F. Doğar, Kadir İsmail Dere, Halil Mutlu, Ökkeş Bilal","doi":"10.5505/vtd.2022.34538","DOIUrl":"https://doi.org/10.5505/vtd.2022.34538","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81095190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fahr Syndrome Diagnosed by the First Attack Psychosis: A Case Report","authors":"Yavuz Selim Atan, U. Kırlı","doi":"10.5505/vtd.2022.35682","DOIUrl":"https://doi.org/10.5505/vtd.2022.35682","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87907373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gozde Sahin, T. Duran, Serkan Küççüktürk, N. Koçak, Denizhan Bayramoğlu, A. Kebapçılar, Ç. Çelik
{"title":"Apoptotic Effect Of Neferine On Cervical Cancer Cells (HeLa)","authors":"Gozde Sahin, T. Duran, Serkan Küççüktürk, N. Koçak, Denizhan Bayramoğlu, A. Kebapçılar, Ç. Çelik","doi":"10.5505/vtd.2022.87094","DOIUrl":"https://doi.org/10.5505/vtd.2022.87094","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90536067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can Ultrasonography-Guided Aspiration be an Alternative to Surgery in Wrist Ganglion Cysts?","authors":"Ensar Türko, Sinan Oguzkaya","doi":"10.5505/vtd.2022.77642","DOIUrl":"https://doi.org/10.5505/vtd.2022.77642","url":null,"abstract":"","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77423456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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