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Corrigendum to Management of osteochondritis dissecans (OCD) of the elbow trochlea in the adolescent population: A systematic review. 青少年肘关节骨软骨炎(OCD)的治疗方法》更正:系统综述。
IF 1.5 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 Epub Date: 2023-08-16 DOI: 10.1177/17585732231197595

[This corrects the article DOI: 10.1177/17585732221079585.].

[This corrects the article DOI: 10.1177/17585732221079585.].
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引用次数: 0
Job satisfaction of healthcare professionals in palliative care departments and factors affecting job satisfaction during COVID-19 pandemic COVID-19大流行期间姑息治疗专业医护人员工作满意度及其影响因素
4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp230831060s
Scepan Sinanovic, Tatjana Kilibarda, Sasa Bubanj, Tanja Prodovic, Srecko Potic, Jelena Sekulic, Marko Spasic, Slobodan Subotic, Marina Kostic, Marko Petrovic, Tatjana Popovic-Ilic, Milena Tomovic, Nikola Aksovic, Olivera Milovanovic
Background/Aim. The COVID-19 pandemic had a significantly impact on the healthcare system, particularly healthcare providers such as nurses, who were obliged to adhere to strict procedures and had to manage their time effectively during their shifts. The aim of this study was to to identify internal strengths, weaknesses, threats, and challenges in palliative care management during the COVID-19 pandemic, from the perspective of nurses. Methods. A cross-sectional research was conducted on a 100% sample of nurses working in hospital-based palliative care in two clinics in Belgrade (47 respondents in total). The research instrument was a Questionnaire on Employee Satisfaction. The survey was conducted during September and October 2022, according to ethical standards and principles. Results. The research revealed that nurses' job satisfaction was moderate (3.43), influenced by adequate financial compensation and the implementation of measures to prevent and control COVID- 19 infection. The dimensions of management significantly related to respondents' satisfaction were motivation and adequacy of hygienic conditions and measures to control COVID-19 infection (?2 = 62.83; p = 0.004** and ?2 = 36.42; p = 0.006**, respectively). Conclusion. Nurses who experienced stress at work in regular conditions tended to react the same way in different conditions, such as those related to COVID-19 infection. The toughest issues for management is recognizing the importance of nurses? job by the social community. Therefore, it is important to respect and support the most important professional values of nurses such as valuable achievements, importance of professional challenge, personal growth and development and independence in one?s practice.
背景/目的。COVID-19大流行对医疗保健系统产生了重大影响,特别是护士等医疗保健提供者,他们有义务遵守严格的程序,必须在轮班期间有效管理时间。本研究的目的是从护士的角度确定COVID-19大流行期间姑息治疗管理的内部优势、劣势、威胁和挑战。方法。对贝尔格莱德两家诊所从事医院姑息治疗工作的100%护士样本(总共47名受访者)进行了横断面研究。研究工具为员工满意度调查问卷。根据道德标准和原则,该调查于2022年9月至10月进行。结果。研究发现,护士的工作满意度为中等(3.43),受足够的经济补偿和预防和控制COVID- 19感染措施的实施的影响。与受访者满意度显著相关的管理维度是卫生条件的动机和充分性,以及控制COVID-19感染的措施(?2 = 62.83;P = 0.004**和?2 = 36.42;P = 0.006**)。结论。在常规条件下经历工作压力的护士在不同条件下(例如与COVID-19感染有关的情况)往往会做出相同的反应。管理人员最棘手的问题是认识到护士的重要性。工作由社会共同体承担。因此,尊重和支持护士最重要的专业价值观,如有价值的成就、专业挑战的重要性、个人成长和发展、独立于一体。年代的做法。
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引用次数: 0
Corrigendum “Prescription patterns of diclofenac in patients with cardiovascular diseases or at high risk for cardiovascular diseases at primary health care level in Montenegro: Retrospective, national, drug utilization study” 更正"黑山初级保健一级心血管疾病或心血管疾病高风险患者双氯芬酸处方模式:回顾性国家药物利用研究"
4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp2310892e
E Editorial
In the original article titled ?Prescription patterns of diclofenac in patients with cardiovascular diseases or at high risk for cardiovascular diseases at primary health care level in Montenegro: retrospective, national, drug utilization study? published in the September 2023 issue of the Vojnosanitetski Pregled 1, the heading for the third, right-hand column of data in Table 1 should have been given as ?Patients with CVD/risk for CVD on diclofenac therapy, n (%)? instead of ?Patients with CVD on diclofenac therapy, n (%)?. 1. Stankovic M, Turkovic N, Dobric S, Rancic N. Prescription patterns of diclofenac in patients with cardiovascular diseases or at high risk for cardiovascular diseases at primary health care level in Montenegro: retrospective, national, drug utilization study. Vojnosanit Pregl 2023; 80(9): 778-88. (DOI: https://doi.org/10.2298/VSP221229021S)

Link to the corrected article 10.2298/VSP221229021S
原文标题为:黑山初级卫生保健水平的心血管疾病或高危心血管疾病患者双氯芬酸的处方模式:回顾性国家药物使用研究?发表在2023年9月的Vojnosanitetski Pregled 1上,表1中右侧第三列数据的标题应该是:CVD患者/双氯芬酸治疗CVD风险,n (%)?而CVD患者接受双氯芬酸治疗,n (%)?1. Stankovic M, Turkovic N, Dobric S, Rancic N.黑山初级卫生保健水平心血管疾病或高危心血管疾病患者双氯芬酸处方模式:回顾性,国家,药物使用研究。生物工程学报,2023;80(9): 778 - 88。(DOI: https://doi.org/10.2298/VSP221229021S) <br><br><font color="red"><链接到更正后的文章<u><a href="http://dx.doi.org/10.2298/VSP221229021S">10.2298/VSP221229021S</a></b><
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引用次数: 0
Neurophysiological confirmation of phrenic nerve affection in patient with dyspnea and herpes zoster 呼吸困难伴带状疱疹患者膈神经受影响的神经生理学证实
IF 0.2 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp200511001m
V. Martić, Aleksandar Stojanov
Introduction. Herpetic lesion of the phrenic nerve is very uncommon. These lesions are usually unilateral and for most clinicians, the clinical manifestation of herpes zoster in the cervical or thoracic region and diaphragmatic paralysis on the same side is sufficient for making a diagnosis of segmental herpes zoster phrenic nerve palsy. We report a patient, who had a classic clinical picture, in which we confirmed phrenic nerve affection on nerve conduction study. Case report. A 58-year-old female patient, presenting with shortness of breath. The patient had a herpetic rash of her right shoulder two and a half months earlier. The elevation of the right hemidiaphragm was seen on chest X-ray imaging. Asymmetry was evident on nerve conduction study of the phrenic nerve: prolonged latency and reduced amplitude of her right phrenic nerve. The patient was treated by acyclovir, pregabalin, and B complex vitamins. After 6 months the motor deficit was completely reduced. Conclusion. Nerve conduction study of the phrenic nerve is useful in making the definitive diagnosis. Good outcome, as in this patient, is rare in patients with this diagnosis and may be linked to timely treatment with acyclovir.
介绍。膈神经的疱疹性病变是非常罕见的。这些病变通常是单侧的,对于大多数临床医生来说,颈部或胸部带状疱疹和同侧膈神经麻痹的临床表现足以诊断节段性带状疱疹膈神经麻痹。我们报告一位有典型临床表现的病人,证实膈神经对神经传导的影响。病例报告。一名58岁女性患者,表现为呼吸短促。两个半月前,病人右肩有疱疹疹。胸部x线显示右半膈升高。膈神经的神经传导研究显示明显的不对称性:右膈神经潜伏期延长,振幅减小。患者给予阿昔洛韦、普瑞巴林和复合维生素B治疗。6个月后,运动缺陷完全减少。结论。膈神经的神经传导检查有助于明确诊断。良好的预后,如本例患者,在这种诊断的患者中是罕见的,可能与及时使用阿昔洛韦治疗有关。
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引用次数: 0
Brown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidism 下颌骨棕色肿瘤-原发性甲状旁腺功能亢进的一种可能临床表现
IF 0.2 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp220809004m
Andrijana Milankov, M. Mitrović, T. Icin, B. Bajkin, Vukadin Milankov
Introduction. One of possible manifestations of primary hyperparathyroidism (PHPT) is the appearance of a benign bone tumor. We hereby present a case of a young woman whose first clinical manifestation of PHPT was a brown tumor of the mandible. Case report. A female patient was hospitalized in the Clinic of Endocrinology, Diabetes and Metabolic Disease due to the problems occurring in the form of nausea, exhaustion, feeling of suffocation, dysphagia, pain in the right ear and the right half of the cheeks, who was under suspicion of primary hyperparathyroidism (PHPT). Initial laboratory findings pointed out the high levels of parathyroid hormone (PTH) and Ca2+ ions, low levels of vitamin D and increased parameters of bone metabolism with signs of osteopenia. Cone beam computed tomography (CBCT) revealed a presence of bilateral radiolucent lesions of the mandible. Scintigraphy showed a retrosternal hot focus consistent with parathyroid adenoma. Parathyroidectomy was performed with following normalization of PTH values, bone metabolism parameters, and normalization of the Ca2+ ion values. Four months after parathyroidectomy, there was a complete resolution of clinical and radiological findings of initial tumefaction of the mandible. Conclusion. Brown tumors are rare first clinical manifestation of PHPT. Because of their histological similarities with other giant-cell lesions (GCL), definitive diagnosis is sometimes difficult, and is based on correlation with radiological and laboratory findings. Due to spontaneous regression of bone lesions after treatment of the basic cause of PHPT, brown tumors should be considered in the differential diagnosis of any giant-cell tumor lesions in order to avoid unnecessary surgical procedure.
介绍。原发性甲状旁腺功能亢进(PHPT)的可能表现之一是出现良性骨肿瘤。我们在此提出一个病例的年轻女性,其PHPT的第一个临床表现是一个棕色肿瘤的下颌骨。病例报告。1例女性患者因出现恶心、乏力、窒息感、吞咽困难、右耳及右半颊疼痛等症状,怀疑为原发性甲状旁腺功能亢进(PHPT),在内分泌、糖尿病及代谢疾病门诊就诊。最初的实验室结果指出,甲状旁腺激素(PTH)和Ca2+离子水平高,维生素D水平低,骨代谢参数增加,伴有骨质减少的迹象。圆锥束计算机断层扫描(CBCT)显示双侧下颌骨的放射性病变。显像显示胸骨后热灶与甲状旁腺瘤一致。甲状旁腺切除术后,PTH值正常化,骨代谢参数和Ca2+离子值正常化。甲状旁腺切除术后4个月,有一个完全解决的临床和影像学表现,最初的下颌骨肿胀。结论。褐色肿瘤是PHPT罕见的首发临床表现。由于其与其他巨细胞病变(GCL)的组织学相似,明确的诊断有时是困难的,并基于放射学和实验室结果的相关性。由于PHPT的基本病因治疗后,骨病变会自发消退,因此在鉴别诊断巨细胞肿瘤病变时应考虑棕色肿瘤,以避免不必要的手术治疗。
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引用次数: 0
Retrospective analysis of hospitalization rates in patients with schizophrenia 12 months before and 12 months after the switch on once-monthly long-acting injectable paliperidone palmitate 精神分裂症患者每月一次长效注射棕榈酸帕利哌酮前后12个月住院率的回顾性分析
IF 0.2 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp221114007t
S. Totić-Poznanović, M. Marković
Background/Aim. There is no available published data about use of long-acting injectable paliperidone palmitate in schizophrenia patients in Republic of Serbia. The aim of this study was to assess hospitalization rates before and after the switch on once monthly longacting injectable paliperidone palmitate in schizophrenia patients, as well as their compliance with this drug. Methods. This was retrospective cross-sectional study which was evaluating hospitalization rates in the period of 12 months before and 12 months after the switch on once-monthly long-acting injectable paliperidone palmitate in 113 schizophrenia patients. The age of enrolled patients was between 18 and 66 years. Results. Average age of enrolled patients was 38.36 ?11.62 years. Among them, 77 (68.1%) were male, and 36 (31.9% ) were female. Out of total number of 113 patients who were treated with once-monthly injectable paliperidone palmitate, 78 (69.03%) was on monotherapy, while 35 (30.97%) had one additional oral antipsychotic (risperidone, olanzapine, aripiprazole or clozapine). Out of total number of 113 patients, 68 (60.18%) were not hospitalized in 12 months period before the switch on once-monthly long-acting injectable paliperidone palmitate, while 45 (39.82%) were hospitalized in the same period. Considering the fact that in the period after the switch on once-monthly injectable paliperidone palmitate 8 patients out of total number of 113, were discontinued from treatment due to adverse event or their own decision, analysis of the hospitalization rate after the switch was performed for remaining 105 patients, and the results showed that 9 (8.57%) were hospitalized in the period of 12 months after the switch, while 96 (91.43%) were not hospitalized in the same period. Conclusion. Our results show high compliance in treatment with once-monthly injectable paliperidone palmitate and positive impact of treatment with this drug on low hospitalization rate in 12 month period in patients with schizophrenia. Considering the availability of this drug in the Republic of Serbia, these results encourge the use of once-monthly injectable paliperidone palmitate as an important therapeutic option in schizophrenia patients
背景/目的。塞尔维亚共和国尚无关于精神分裂症患者使用长效注射棕榈酸帕利哌酮的公开数据。本研究的目的是评估精神分裂症患者每月一次长效注射棕榈酸帕利哌酮前后的住院率,以及他们对这种药物的依从性。方法。这是一项回顾性横断面研究,评估113例精神分裂症患者每月一次长效注射棕榈酸帕利哌酮前后12个月的住院率。入组患者的年龄在18至66岁之间。结果。入组患者平均年龄为38.36 ~ 11.62岁。其中男性77例(68.1%),女性36例(31.9%)。在113例接受每月一次注射棕榈酸帕利哌酮治疗的患者中,78例(69.03%)接受单药治疗,35例(30.97%)接受另外一种口服抗精神病药(利培酮、奥氮平、阿立哌唑或氯氮平)。113例患者中,68例(60.18%)患者在改用每月一次长效注射棕榈酸帕利哌酮前的12个月内未住院,而45例(39.82%)患者同期住院。考虑到113例患者中有8例因不良事件或自行决定停用棕榈酸帕利哌酮,对其余105例患者进行切换后住院率分析,结果显示,切换后12个月内住院9例(8.57%),同期未住院96例(91.43%)。结论。我们的研究结果显示,每月一次注射棕榈酸帕利哌酮治疗精神分裂症患者的依从性高,并且该药物治疗对12个月期间住院率低有积极影响。考虑到这种药物在塞尔维亚共和国的可获得性,这些结果鼓励使用每月一次的可注射棕榈酸帕利哌酮作为精神分裂症患者的重要治疗选择
{"title":"Retrospective analysis of hospitalization rates in patients with schizophrenia 12 months before and 12 months after the switch on once-monthly long-acting injectable paliperidone palmitate","authors":"S. Totić-Poznanović, M. Marković","doi":"10.2298/vsp221114007t","DOIUrl":"https://doi.org/10.2298/vsp221114007t","url":null,"abstract":"Background/Aim. There is no available published data about use of long-acting injectable paliperidone palmitate in schizophrenia patients in Republic of Serbia. The aim of this study was to assess hospitalization rates before and after the switch on once monthly longacting injectable paliperidone palmitate in schizophrenia patients, as well as their compliance with this drug. Methods. This was retrospective cross-sectional study which was evaluating hospitalization rates in the period of 12 months before and 12 months after the switch on once-monthly long-acting injectable paliperidone palmitate in 113 schizophrenia patients. The age of enrolled patients was between 18 and 66 years. Results. Average age of enrolled patients was 38.36 ?11.62 years. Among them, 77 (68.1%) were male, and 36 (31.9% ) were female. Out of total number of 113 patients who were treated with once-monthly injectable paliperidone palmitate, 78 (69.03%) was on monotherapy, while 35 (30.97%) had one additional oral antipsychotic (risperidone, olanzapine, aripiprazole or clozapine). Out of total number of 113 patients, 68 (60.18%) were not hospitalized in 12 months period before the switch on once-monthly long-acting injectable paliperidone palmitate, while 45 (39.82%) were hospitalized in the same period. Considering the fact that in the period after the switch on once-monthly injectable paliperidone palmitate 8 patients out of total number of 113, were discontinued from treatment due to adverse event or their own decision, analysis of the hospitalization rate after the switch was performed for remaining 105 patients, and the results showed that 9 (8.57%) were hospitalized in the period of 12 months after the switch, while 96 (91.43%) were not hospitalized in the same period. Conclusion. Our results show high compliance in treatment with once-monthly injectable paliperidone palmitate and positive impact of treatment with this drug on low hospitalization rate in 12 month period in patients with schizophrenia. Considering the availability of this drug in the Republic of Serbia, these results encourge the use of once-monthly injectable paliperidone palmitate as an important therapeutic option in schizophrenia patients","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connection between discolored gingiva of abutment teeth and presence of cast post 基牙牙龈变色与铸桩存在的关系
IF 0.2 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp221203012r
L. Ristic, V. Lazić, Srdjan Postic, Nenad Jelic, I. Djordjevic, R. Mladenović
Background/Aim. The cause of discolored gingiva (DG) is the presence of metal in the gingival tissue. DG is a relatively common case, and is caused by deposition of amalgam material in the gingival tissue during dental application or oral surgery. The aim of this study was to determine the significance of cast post presence for appearance of DG of abutment teeth (AT) in relation to the type of fixed dental prosthesis (FDP) alloy. Methods. The study included 327 subjects with FDP. A total of 1585 AT were examined. Subjects were classified into four groups depending on the type of alloy of which their FDPs were fabricated of (silver-palladium, gold, nickel-chromium alloy or a combination of them). The presence of a cast post was confirmed by X-ray or by inspection of the dental chart. The data were collected within one year. Results. DG was observed in more than one third (37.7%) of the subjects of which 57.3% had a cast post . In the case of AT, discoloration occured in 14.6% of them. Cast post was present in 92.7% of AT with DG. Conclusion. DG occured in all groups of subjects regardless of the type of alloy from which the FDP was fabricated. The presence of a cast post is of great significance for the appearance of gray-bluish discoloration of the gingiva.
背景/目的。牙龈变色(DG)的原因是存在于牙龈组织中的金属。DG是一种比较常见的病例,是由于牙科应用或口腔手术过程中汞合金物质沉积在牙龈组织中引起的。本研究的目的是确定铸造桩存在对基牙(AT) DG外观的意义与固定义齿(FDP)合金的类型有关。方法。该研究包括327名FDP患者。共检测了1585个AT。根据制作fdp的合金类型(银钯合金、金合金、镍铬合金或它们的组合),受试者被分为四组。通过x光或检查牙科图表确认了铸造桩的存在。数据是在一年内收集的。结果。超过三分之一(37.7%)的受试者有DG,其中57.3%的受试者有铸造桩。在AT的情况下,14.6%的人出现了变色。铸柱存在于92.7%的AT与DG。结论。无论制作FDP的合金类型如何,所有组的受试者都出现了DG。铸造桩的存在对牙龈灰蓝色变色的外观具有重要意义。
{"title":"Connection between discolored gingiva of abutment teeth and presence of cast post","authors":"L. Ristic, V. Lazić, Srdjan Postic, Nenad Jelic, I. Djordjevic, R. Mladenović","doi":"10.2298/vsp221203012r","DOIUrl":"https://doi.org/10.2298/vsp221203012r","url":null,"abstract":"Background/Aim. The cause of discolored gingiva (DG) is the presence of metal in the gingival tissue. DG is a relatively common case, and is caused by deposition of amalgam material in the gingival tissue during dental application or oral surgery. The aim of this study was to determine the significance of cast post presence for appearance of DG of abutment teeth (AT) in relation to the type of fixed dental prosthesis (FDP) alloy. Methods. The study included 327 subjects with FDP. A total of 1585 AT were examined. Subjects were classified into four groups depending on the type of alloy of which their FDPs were fabricated of (silver-palladium, gold, nickel-chromium alloy or a combination of them). The presence of a cast post was confirmed by X-ray or by inspection of the dental chart. The data were collected within one year. Results. DG was observed in more than one third (37.7%) of the subjects of which 57.3% had a cast post . In the case of AT, discoloration occured in 14.6% of them. Cast post was present in 92.7% of AT with DG. Conclusion. DG occured in all groups of subjects regardless of the type of alloy from which the FDP was fabricated. The presence of a cast post is of great significance for the appearance of gray-bluish discoloration of the gingiva.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical manifestation of Johanson-Blizzard syndrome in patient with nucleotide variants in UBR1 gene UBR1基因核苷酸变异患者约翰逊-暴雪综合征的临床表现
IF 0.2 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp220803003j
D. Jojkic-pavkov, Jela Tosic, I. Kavecan, Milica Plazacic
Introduction. Johanson-Blizzard syndrome is a very rare genetic disorder caused by a mutation of the ubiquitin protein ligase E3 component N-recognin 1 (UBR1). Clinical diagnosis is based on the pathognomonic combination of congenital exocrine pancreatic insufficiency with facial dysmorphology (nasal wing hypo/aplasia, and oligodontia of permanent teeth). Diagnosis is confirmed by genetic screening of the UBR1 gene. The purpose of this case report is to emphasize that nucleotide variants in the UBR1 gene that are described as benign or unclassified should be considered as genetic causes in patients with clinical characteristics of Johanson-Blizzard syndrome. Case report. In this report, we present an 8-month old child who was admitted to our hospital due to poor weight gain and loose stools. On admission, the signs of protein-energy malnutrition, with facial dysmorphological signs and other anomalies, were observed. He had hypotonia and convergent strabismus. A laboratory examination confirmed exocrine pancreatic insufficiency and hypothyroidism. Genetic testing confirmed two single nucleotide variants in ubiquitin protein ligase E3 component N-Recognin 1, chromosome 15q15.2: NM_174916.3:c.4700+12A>G (intron 42), and NM_174916.3 UBR1:c.862-18C>T (intron 07). A pancreatic enzyme replacement therapy with liposoluble vitamin supplementation and adequate nutrition was conducted. Conclusion. Recognition of clinical features of Johanson-Blizzard syndrome and genetic confirmation is very important, especially in patients with idiopathic pancreatic insufficiency. Even when genetic confirmation is not possible, adequate treatment is necessary for normal growth and development of the child.
介绍。johnson - blizzard综合征是一种非常罕见的遗传疾病,由泛素蛋白连接酶E3组分n-识别蛋白1 (UBR1)突变引起。临床诊断是基于先天性外分泌胰腺功能不全与面部畸形(鼻翼发育不全、恒牙少齿)的病理特征组合。通过UBR1基因的遗传筛查确诊。本病例报告的目的是强调在具有johnson - blizzard综合征临床特征的患者中,被描述为良性或未分类的UBR1基因核苷酸变异应被视为遗传原因。病例报告。在这个报告中,我们报告了一个8个月大的孩子,他因体重增加不佳和大便疏松而入院。入院时,观察到蛋白质能量营养不良的迹象,面部畸形迹象和其他异常。他有强直和会聚性斜视。实验室检查证实外分泌胰功能不全和甲状腺功能减退。基因检测证实泛素蛋白连接酶E3组分n - recognin1在染色体15q15.2和NM_174916.3:c中存在两个单核苷酸变异。4700+12A>G(内含子42)和NM_174916.3 UBR1:c。862- 18c>t(内含子07)。胰酶替代治疗与脂溶性维生素补充和适当的营养进行。结论。认识约翰逊-暴雪综合征的临床特征和遗传学确认是非常重要的,特别是对特发性胰腺功能不全的患者。即使不能从基因上证实,为了儿童的正常生长和发育,适当的治疗也是必要的。
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引用次数: 0
Post-treatment periapical status related to the quality of root canal fillings in adults living in Vojvodina 伏伊伏丁那地区成人治疗后根尖周状态与根管充填质量的关系
IF 0.2 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp220923005r
B. Ramić, Karolina Vukoje, Milica Cvjeticanin, Tanja Veljović, J. Mirnic, Aleksandra Maletin, M. Drobac, Milos Cankovic, L. Petrovic
Background/Aim. Apical periodontitis (AP) is an acute or chronic inflammation of the periradicular tissue, usually caused by the presence of microbial irritants in the root canal system. The aim of the present study was to radiographically investigate the AP prevalence in root-filled teeth in adults from an urban area of Vojvodina. Methods. Randomly selected digital ortopantomographs of 616 subjects attending the Clinic of Dentistry of Vojvodina, Serbia, were examined. Periapical status, root canal filling (RCF) quality, type of coronal restorations, and their relationships were evaluated. The chi-square test was used for statistical analysis. Results. The total number of endodontically treated teeth was 965, 44.2% of them received an adequate RCF score, and 34.9% had AP, which was diagnosed in 57.4% of inadequately scored root-filled teeth. Posterior teeth had significantly worse RCF quality than anterior teeth (p < 0.001). The direct logistic regression results indicate that a technically well-performed RCF reduced the risk of AP almost 21-fold. The prevalence of AP in our cohort was not influenced by the type of restoration (direct or indirect), but statistically significantly, the highest prevalence of AP was found in rootfilled teeth without any coronal restoration. Conclusion. The results of this study reaffirm that technically high-quality root canal treatment is crucial to ensure a more predictable root canal treatment outcome.
背景/目的。根尖牙周炎(AP)是根周组织的一种急性或慢性炎症,通常由根管系统中微生物刺激物的存在引起。本研究的目的是影像学调查伏伊伏丁那市市区成人补根牙中AP的患病率。方法。随机选择616名塞尔维亚伏伊伏丁那牙科诊所的患者进行数字口腔断层摄影检查。评估根尖周状态、根管充填质量、冠状修复体类型及其相互关系。统计学分析采用卡方检验。结果。根管治疗的牙齿总数为965颗,其中RCF评分达标的占44.2%,AP发生率为34.9%,其中评分不达标的占57.4%。后牙sercf质量明显低于前牙(p < 0.001)。直接逻辑回归结果表明,技术上表现良好的RCF将AP的风险降低了近21倍。在我们的队列中,AP的患病率不受修复类型(直接或间接)的影响,但具有统计学意义的是,未进行冠状修复的补根牙齿中AP的患病率最高。结论。本研究的结果重申,技术上高质量的根管治疗对于确保更可预测的根管治疗结果至关重要。
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引用次数: 0
Age-independent association between high-sensitivity c-reactive protein and blood pressure in middle-aged adults 高敏c反应蛋白与中年人血压的年龄无关关系
IF 0.2 4区 医学 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.2298/vsp221130042z
Huijun Zhao, Yi-wen Lu, Junjie Niu, Hong Bian, X. Kuang
Background/Aim. Increasingly evidence showed that high-sensitivity C-reactive protein (hs-CRP) is a reliable biomarker in patients with hypertension. While the relationship between hypertension and age is well established, the connection between hs-CRP and age remains unclear. The aim of the study was to determine a relationship between hs-CRP and age in middle-aged people. Methods. This crosssectional survey was conducted in Shanghai, China, and included data from 1,677 healthy male participants aged 18 to 50 years and 1,127 healthy female participants aged 19 to 49 years, who were recruited during routine health examinations. The hs-CRP, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP) were recorded. Results. The participants were first separated into four age quartile groups, and an increase in BMI, SBP, and DBP was observed, but not in hs-CRP. Next, the participants were divided into four hs-CRP quartile groups and an increase in BMI, SBP, and DBP was noted, but not in age. Finally, using Pearson correlation, positive correlations were found between hs-CRP, BMI, SBP, and DBP, but no correlation was seen between age and hs-CRP. Conclusion. The authors showed that age is likely a confounding factor that has a correlation with SBP, DBP, and BMI, but it does not have a direct correlation with hs-CRP.
背景/目的。越来越多的证据表明,高敏c反应蛋白(hs-CRP)是高血压患者可靠的生物标志物。虽然高血压与年龄之间的关系已经确立,但hs-CRP与年龄之间的关系尚不清楚。该研究的目的是确定hs-CRP与中年人年龄之间的关系。方法。本横断面调查在中国上海进行,包括1677名年龄在18至50岁之间的健康男性参与者和1127名年龄在19至49岁之间的健康女性参与者的数据,他们是在常规健康检查期间招募的。记录hs-CRP、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)。结果。参与者首先被分成四个年龄四分位数组,观察到BMI、收缩压和舒张压的增加,但hs-CRP没有增加。接下来,参与者被分成四个hs-CRP四分之一组,BMI、收缩压和舒张压都有所增加,但年龄没有变化。最后,采用Pearson相关分析,hs-CRP与BMI、收缩压、舒张压呈正相关,年龄与hs-CRP无相关性。结论。作者表明,年龄可能是一个与收缩压、舒张压和BMI相关的混杂因素,但它与hs-CRP没有直接相关性。
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