Nora Mihalek, Dragana Radovanovic, Sanja Starcevic, Jelena Vukoje, Daniel Juhas
Background/Aim. Postoperative nausea and vomiting (PONV) is one of the most common causes of patient dissatisfaction in the postoperative period after general anaesthesia. Hyperoxia may prevent PONV after abdominal surgery, but the effectiveness of intraoperative and early postoperative hyperoxia in preventing PONV after breast cancer surgery has not been adequately studied so far. Methods. Forty female patients with breast cancer were recruited, all of whom underwent surgical treatment of breast cancer with axillary sentinel node sampling or axillary lymph node dissection. Balanced general anaesthesia with propofol induction and sevofluran maintenance was administered. Twenty patients received a volatile mixture with inspiratory fraction of inspired oxygen (FiO2) of 0.8 intraoperatively and 3 L/min oxygen via face mask for two hours after surgery. The other 20 patients received a FiO2 of 0.4 during the intervention, without further administration of oxygen in the early postoperative period. The presence and severity of PONV was assessed at 30 minutes, 4/24/32/48/56 hours after surgery and a numerical PONV Intensity Scale by Wengritzky was applied to evaluate clinically significant PONV in the first 6 hours after surgery. Data were collected in Excel spreadsheet and analysed using the independent Student's t-test. Results. The overall incidence of PONV 30 minutes after the intervention was 17.5% (15% in the group of patients receiving FiO2 of 0.8 intraoperatively and 20% in the group of patients receiving volatile mixture with FiO2 of 0.4). There was no statistically significant difference (p?0.05) between the two groups in the frequency and severity of PONV, as well as in the values of PONV Intensity Score by Wengritzky. Conclusion. We found no benefit of intraand postoperative hyperoxia in reducing the incidence of PONV. The data do not support routine administration of hyperoxia in addition to antiemetics in patients undergoing breast cancer surgery for the prevention of PONV.
{"title":"Hyperoxia for prevention of postoperative nausea and vomiting after breast cancer surgery (PONV-breast study) - a randomised controlled trial","authors":"Nora Mihalek, Dragana Radovanovic, Sanja Starcevic, Jelena Vukoje, Daniel Juhas","doi":"10.2298/vsp230522059m","DOIUrl":"https://doi.org/10.2298/vsp230522059m","url":null,"abstract":"Background/Aim. Postoperative nausea and vomiting (PONV) is one of the most common causes of patient dissatisfaction in the postoperative period after general anaesthesia. Hyperoxia may prevent PONV after abdominal surgery, but the effectiveness of intraoperative and early postoperative hyperoxia in preventing PONV after breast cancer surgery has not been adequately studied so far. Methods. Forty female patients with breast cancer were recruited, all of whom underwent surgical treatment of breast cancer with axillary sentinel node sampling or axillary lymph node dissection. Balanced general anaesthesia with propofol induction and sevofluran maintenance was administered. Twenty patients received a volatile mixture with inspiratory fraction of inspired oxygen (FiO2) of 0.8 intraoperatively and 3 L/min oxygen via face mask for two hours after surgery. The other 20 patients received a FiO2 of 0.4 during the intervention, without further administration of oxygen in the early postoperative period. The presence and severity of PONV was assessed at 30 minutes, 4/24/32/48/56 hours after surgery and a numerical PONV Intensity Scale by Wengritzky was applied to evaluate clinically significant PONV in the first 6 hours after surgery. Data were collected in Excel spreadsheet and analysed using the independent Student's t-test. Results. The overall incidence of PONV 30 minutes after the intervention was 17.5% (15% in the group of patients receiving FiO2 of 0.8 intraoperatively and 20% in the group of patients receiving volatile mixture with FiO2 of 0.4). There was no statistically significant difference (p?0.05) between the two groups in the frequency and severity of PONV, as well as in the values of PONV Intensity Score by Wengritzky. Conclusion. We found no benefit of intraand postoperative hyperoxia in reducing the incidence of PONV. The data do not support routine administration of hyperoxia in addition to antiemetics in patients undergoing breast cancer surgery for the prevention of PONV.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135051900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milica Djurdjevic, M. Bubalo, A. Lukovic, Ana Igić, Aleksandar Acović, T. Kanjevac
Background/Aim. Insufficient bone thickness (thickness less than 2 mm) frequently leads to fenestration and dehiscence, leading to additional bone resorption. Cone beam computed tomography (CBCT) is becoming a priority in the diagnosis of bone thickness needed for implant placement. It has proven to be an accurate and largely reliable diagnostic tool in the image of morphology and buccal wall thickness. The aim of this study was to measure the vestibular bone thickness of the anterior maxillary region in Serbian population and compare the difference between men and women, left and right sides of the jaw. Methods. CBCT images of 68 patients were examined from the existing database. The length from the cemento-enamel junction to the beginning of the alveolar bone was measured, followed by the thickness of the vestibular bone at various clinically relevant locations. Results. The data were statistically processed, analyzing a total of 373 teeth of the frontal region of the upper jaw, including 128 central incisors, 124 lateral incisors and 121 canines. The analysis of this study showed that the thickness of the buccal bone in more than 88% cases was less than 1.5 mm at all reference points, with mean values from 0.72 to 1.02 mm. Conclusion. A very small number of maxillary teeth have a vestibular bone thickness > 2 mm; therefore, the criterion to provide at least 2 mm of thickness needed for implant placement is difficult to meet. This increases the use of auxiliary methods of bone augmentation during immediate implant placement.
{"title":"Cone beam computed tomography analysis of maxillary vestibular bone thickness in the esthetic region","authors":"Milica Djurdjevic, M. Bubalo, A. Lukovic, Ana Igić, Aleksandar Acović, T. Kanjevac","doi":"10.2298/vsp221110032d","DOIUrl":"https://doi.org/10.2298/vsp221110032d","url":null,"abstract":"Background/Aim. Insufficient bone thickness (thickness less than 2 mm) frequently leads to fenestration and dehiscence, leading to additional bone resorption. Cone beam computed tomography (CBCT) is becoming a priority in the diagnosis of bone thickness needed for implant placement. It has proven to be an accurate and largely reliable diagnostic tool in the image of morphology and buccal wall thickness. The aim of this study was to measure the vestibular bone thickness of the anterior maxillary region in Serbian population and compare the difference between men and women, left and right sides of the jaw. Methods. CBCT images of 68 patients were examined from the existing database. The length from the cemento-enamel junction to the beginning of the alveolar bone was measured, followed by the thickness of the vestibular bone at various clinically relevant locations. Results. The data were statistically processed, analyzing a total of 373 teeth of the frontal region of the upper jaw, including 128 central incisors, 124 lateral incisors and 121 canines. The analysis of this study showed that the thickness of the buccal bone in more than 88% cases was less than 1.5 mm at all reference points, with mean values from 0.72 to 1.02 mm. Conclusion. A very small number of maxillary teeth have a vestibular bone thickness > 2 mm; therefore, the criterion to provide at least 2 mm of thickness needed for implant placement is difficult to meet. This increases the use of auxiliary methods of bone augmentation during immediate implant placement.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Gluscevic, A. Stanojković, Dragica Bukumiric, Danilo Jeremic
Background/Aim. There are few research papers in Serbia reporting on the clinical results of scarf osteotomy and its long-term effects. The aim of this retrospective study was to evaluate the efficacy of the scarf osteotomy in hallux valgus (HV) deformity correction, as well as the degree of recurrence and its possible causes. Methods. The study included 48 patients (52 feet) who underwent scarf osteotomy. Average follow-up time was 103.9 months (63-156). In order to clinically evaluate the results, the scale of the American Orthopedic Foot and Ankle Society (AOFAS) and the Visual Analogue Scale (VAS) of pain were used. Preoperatively and postoperatively, in order to radiographically determine the degree of deformity, radiographs of the feet were taken in the standing position and the parameters determined were: HV angle (HVA), intermetatarsal angle (IMTA), distal metatarsal articular angle (DMTAA) and sesamoid position. Results. The AOFAS scores increased from 19 (5-45) points preoperatively, to 92 (54-100) points at the time of the latest follow-up examination (p < 0.001). The VAS values significantly improved from 10 (8-10) preoperatively, to 0 (0-6). The average HVA correction was 24.8?. The recurrence rate in patients in whom the HVA was greater than 20? was 26.9%. Conclusion. Although scarf osteotomy is a proven procedure for the correction of HV, long-term results still show a relatively high rate of recurrence.
{"title":"Clinical results of scarf osteotomy","authors":"B. Gluscevic, A. Stanojković, Dragica Bukumiric, Danilo Jeremic","doi":"10.2298/vsp221226015g","DOIUrl":"https://doi.org/10.2298/vsp221226015g","url":null,"abstract":"Background/Aim. There are few research papers in Serbia reporting on the clinical results of scarf osteotomy and its long-term effects. The aim of this retrospective study was to evaluate the efficacy of the scarf osteotomy in hallux valgus (HV) deformity correction, as well as the degree of recurrence and its possible causes. Methods. The study included 48 patients (52 feet) who underwent scarf osteotomy. Average follow-up time was 103.9 months (63-156). In order to clinically evaluate the results, the scale of the American Orthopedic Foot and Ankle Society (AOFAS) and the Visual Analogue Scale (VAS) of pain were used. Preoperatively and postoperatively, in order to radiographically determine the degree of deformity, radiographs of the feet were taken in the standing position and the parameters determined were: HV angle (HVA), intermetatarsal angle (IMTA), distal metatarsal articular angle (DMTAA) and sesamoid position. Results. The AOFAS scores increased from 19 (5-45) points preoperatively, to 92 (54-100) points at the time of the latest follow-up examination (p < 0.001). The VAS values significantly improved from 10 (8-10) preoperatively, to 0 (0-6). The average HVA correction was 24.8?. The recurrence rate in patients in whom the HVA was greater than 20? was 26.9%. Conclusion. Although scarf osteotomy is a proven procedure for the correction of HV, long-term results still show a relatively high rate of recurrence.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Premovic Cvjeticanin, B. Ramić, Karolina Vukoje, M. Drobac, I. Stojanac, L. Petrovic
Background/Aim. The ability to effectively and consistently penetrate into dentinal tubules is considered as a favorable factor of root canal sealers RCS). The aim of the study was to assess the penetration depth into dentinal tubules of three RCS combined with four obturation techniques. Methods. Mesial canals of 66 extracted human mandibular molars were endodontically prepared and randomly allocated into 12 experimental groups depending on the sealer type used (AH Plus, EndoREZ, Sealapex) and the obturation technique applied (Cold Lateral compaction, Cone-Fit, Carrier-based, Warm Vertical compaction). Using scanning electron microscopy (SEM), transversal root cross-sections were analyzed and the maximum depth of sealer penetration was measured (396 sections in total corresponded to the apical, middle and coronary third). Results. Group AH Plus/Warm Vertical compaction yielded the highest penetration depth - 1,165 ?m, followed by EndoREZ/Cone-Fit - 1,154 ?m; the lowest depth was measured for EndoREZ/Warm Vertical compaction - 502 ?m. The maximum penetration depth of sealers in the coronary thirds (common mean value) yielded 1,204 ?m, in the middle thirds - 1,005 ?m and in the apical thirds - 770 ?m. AH plus penetrated deeper into dentinal tubules when the obturation techniques with heated gutta-percha were applied, while the opposite findings were obtained for EndoREZ. Conclusion. The sealer penetration depth appears to be influenced by the sealer type used, as well as the obturation technique applied.
{"title":"Scenning electron microscopy (SEM) assessment of tubular penetration depth of root canal sealers combined with different obturation techniques","authors":"Premovic Cvjeticanin, B. Ramić, Karolina Vukoje, M. Drobac, I. Stojanac, L. Petrovic","doi":"10.2298/vsp221017028c","DOIUrl":"https://doi.org/10.2298/vsp221017028c","url":null,"abstract":"Background/Aim. The ability to effectively and consistently penetrate into dentinal tubules is considered as a favorable factor of root canal sealers RCS). The aim of the study was to assess the penetration depth into dentinal tubules of three RCS combined with four obturation techniques. Methods. Mesial canals of 66 extracted human mandibular molars were endodontically prepared and randomly allocated into 12 experimental groups depending on the sealer type used (AH Plus, EndoREZ, Sealapex) and the obturation technique applied (Cold Lateral compaction, Cone-Fit, Carrier-based, Warm Vertical compaction). Using scanning electron microscopy (SEM), transversal root cross-sections were analyzed and the maximum depth of sealer penetration was measured (396 sections in total corresponded to the apical, middle and coronary third). Results. Group AH Plus/Warm Vertical compaction yielded the highest penetration depth - 1,165 ?m, followed by EndoREZ/Cone-Fit - 1,154 ?m; the lowest depth was measured for EndoREZ/Warm Vertical compaction - 502 ?m. The maximum penetration depth of sealers in the coronary thirds (common mean value) yielded 1,204 ?m, in the middle thirds - 1,005 ?m and in the apical thirds - 770 ?m. AH plus penetrated deeper into dentinal tubules when the obturation techniques with heated gutta-percha were applied, while the opposite findings were obtained for EndoREZ. Conclusion. The sealer penetration depth appears to be influenced by the sealer type used, as well as the obturation technique applied.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"35 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irfan Sabotic, Jovan Ilic, Aleksandar Kostić, Marija Djordjević, Vesna Nikolov, M. Radisavljevic, Boban Jelenkovic, N. Stojanovic
Background/Aim. There are several serious complications that can accompany both spontaneous and posttraumatic subarachnoid hemorrhage (SAH) such as the development of intracranial hypertension, hydrocephalus, rebleeding, cerebral hypoxia, cerebral vasospasm, impaired pituitary function, electrolyte imbalance and electrocardiographic (ECG) abnormalities. Although there is a declining trend in mortality, the treatment of SAH and its complications represents a challenge even in imposing neurosurgical centers. Therefore, the aim of the study was to compare some clinical characteristics and complications between spontaneous and posttraumatic SAH. Methods. This retrospective study included 138 patients treated at the Clinic for Neurosurgery in the period from January of 2018 to the January of 2023. There were 71 patients with spontaneous and 67 patients with posttraumatic SAH. Results. A predominance of spontaneous SAH in female and posttraumatic SAH in male patients (p < 0.00001) was found. There was a statistically significant difference in the frequency of hydrocephalus between groups of spontaneous and posttraumatic SAH patients (p = 0.012663). Cerebral vasospasm was significantly more prevalent in patients with spontaneous SAH (p = 0.000091). A statistically significant association was also obtained between the thickness of the coagulum in these two groups (p = 0.000187). Patients with spontaneous SAH were significantly more likely to have a negative T wave (p = 0.000315). Furthermore, there was no statistically significant difference regarding electrolyte imbalance in these two groups of patients with SAH. Conclusion. There were statistically significant differences between gender distribution, the frequency of abnormal ECG findings in the form of a negative T wave, greater coagulum thickness, vasospasm occurrence and a higher rate of hydrocephalus in patients with spontaneous SAH compared to patients with posttraumatic SAH.
{"title":"Clinical and radiological characteristics of patients with spontaneous and posttraumatic subarachnoid hemorrhage: A retrospective observational study","authors":"Irfan Sabotic, Jovan Ilic, Aleksandar Kostić, Marija Djordjević, Vesna Nikolov, M. Radisavljevic, Boban Jelenkovic, N. Stojanovic","doi":"10.2298/vsp230208023s","DOIUrl":"https://doi.org/10.2298/vsp230208023s","url":null,"abstract":"Background/Aim. There are several serious complications that can accompany both spontaneous and posttraumatic subarachnoid hemorrhage (SAH) such as the development of intracranial hypertension, hydrocephalus, rebleeding, cerebral hypoxia, cerebral vasospasm, impaired pituitary function, electrolyte imbalance and electrocardiographic (ECG) abnormalities. Although there is a declining trend in mortality, the treatment of SAH and its complications represents a challenge even in imposing neurosurgical centers. Therefore, the aim of the study was to compare some clinical characteristics and complications between spontaneous and posttraumatic SAH. Methods. This retrospective study included 138 patients treated at the Clinic for Neurosurgery in the period from January of 2018 to the January of 2023. There were 71 patients with spontaneous and 67 patients with posttraumatic SAH. Results. A predominance of spontaneous SAH in female and posttraumatic SAH in male patients (p < 0.00001) was found. There was a statistically significant difference in the frequency of hydrocephalus between groups of spontaneous and posttraumatic SAH patients (p = 0.012663). Cerebral vasospasm was significantly more prevalent in patients with spontaneous SAH (p = 0.000091). A statistically significant association was also obtained between the thickness of the coagulum in these two groups (p = 0.000187). Patients with spontaneous SAH were significantly more likely to have a negative T wave (p = 0.000315). Furthermore, there was no statistically significant difference regarding electrolyte imbalance in these two groups of patients with SAH. Conclusion. There were statistically significant differences between gender distribution, the frequency of abnormal ECG findings in the form of a negative T wave, greater coagulum thickness, vasospasm occurrence and a higher rate of hydrocephalus in patients with spontaneous SAH compared to patients with posttraumatic SAH.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Complex visual hallucinations with retention of insight due to visual impairment are key symptoms of Charles Bonnet syndrome. The syndrome is a standalone diagnosis in ICD-11, but in clinical praxis is often misdiagnosed as psychosis or early stages of dementia and goes underreported by patients because of the fear being diagnosed with a mental illness. Case report. We present four cases of visual hallucinations in elderly patients with impaired vision who had retained insight and referred for psychiatric consultation. All four patients had complex, vivid and colorful hallucinations consisted of realistic objects, people, animals or scenery that tend to recur. Their emotional response and impact on quality of life differed, and psychopharmacotherapy was recommended depending on their psychological symptoms. Empathic explanation of the symptoms origin and reassurance of absence of mental illness for patients and caregivers are of vital importance in all cases. Conclusion. The aging of the population increase the consequence in the number of patients with impaired vision emphasize a multidisciplinary approach in Charles Bonnet syndrome diagnostic procedures and treatment. Increased awareness of clinical characteristic and therapeutic approaches is required among all physicians in contact with elderly and/or impaired vision patients.
{"title":"Complex visual hallucinations with retention of insight: Four cases of Charles bonnet syndrome","authors":"Vesna Tepsic-Ostojic, Zagorka Gojkovic, Bratislav Zivic","doi":"10.2298/vsp230210022t","DOIUrl":"https://doi.org/10.2298/vsp230210022t","url":null,"abstract":"Introduction. Complex visual hallucinations with retention of insight due to visual impairment are key symptoms of Charles Bonnet syndrome. The syndrome is a standalone diagnosis in ICD-11, but in clinical praxis is often misdiagnosed as psychosis or early stages of dementia and goes underreported by patients because of the fear being diagnosed with a mental illness. Case report. We present four cases of visual hallucinations in elderly patients with impaired vision who had retained insight and referred for psychiatric consultation. All four patients had complex, vivid and colorful hallucinations consisted of realistic objects, people, animals or scenery that tend to recur. Their emotional response and impact on quality of life differed, and psychopharmacotherapy was recommended depending on their psychological symptoms. Empathic explanation of the symptoms origin and reassurance of absence of mental illness for patients and caregivers are of vital importance in all cases. Conclusion. The aging of the population increase the consequence in the number of patients with impaired vision emphasize a multidisciplinary approach in Charles Bonnet syndrome diagnostic procedures and treatment. Increased awareness of clinical characteristic and therapeutic approaches is required among all physicians in contact with elderly and/or impaired vision patients.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isidora Arsenović, A. Bogdanović, D. Šefer, Miroslav Pavlovic, Jelena Ivanović, M. Smiljanić, D. Leković
Introduction. Thymic hyperplasia is a rare condition caused by increase in cellular thymic mass, and in some cases is associated with pure red cell aplasia (PRCA). Case report. The patient, an 18-year-old female, was referred to hematologist due to severe transfusion dependent anemia. After full hematological work up included bone marrow biopsy a diagnosis of PRCA was made. Immunological and virological analyses were unremarkable. With history of myasthenia gravis in family and known association between this condition and thymoma, a chest magnet resonance imaging was performed revealing thymic hyperplasia, with successful clinical outcome after total thymectomy using video-assisted thoracic surgery approach. Pathohistological examination confirmed thymus hyperplasia with a simple intrathymic cyst. Following thymectomy, after 3 months the patient's hemoglobin values normalized which still persist. Conclusion. Acquired thymic hyperplasia is associated with the occurrence of autoimmune disorders. Our findings support the role of thymectomy in PRCA associated with thymic hyperplasia, but further research is needed to optimize management strategies for this rarity.
{"title":"Thymic hyperplasia as a rare etiology of pure red cell aplasia: A case report","authors":"Isidora Arsenović, A. Bogdanović, D. Šefer, Miroslav Pavlovic, Jelena Ivanović, M. Smiljanić, D. Leković","doi":"10.2298/vsp230803045a","DOIUrl":"https://doi.org/10.2298/vsp230803045a","url":null,"abstract":"Introduction. Thymic hyperplasia is a rare condition caused by increase in cellular thymic mass, and in some cases is associated with pure red cell aplasia (PRCA). Case report. The patient, an 18-year-old female, was referred to hematologist due to severe transfusion dependent anemia. After full hematological work up included bone marrow biopsy a diagnosis of PRCA was made. Immunological and virological analyses were unremarkable. With history of myasthenia gravis in family and known association between this condition and thymoma, a chest magnet resonance imaging was performed revealing thymic hyperplasia, with successful clinical outcome after total thymectomy using video-assisted thoracic surgery approach. Pathohistological examination confirmed thymus hyperplasia with a simple intrathymic cyst. Following thymectomy, after 3 months the patient's hemoglobin values normalized which still persist. Conclusion. Acquired thymic hyperplasia is associated with the occurrence of autoimmune disorders. Our findings support the role of thymectomy in PRCA associated with thymic hyperplasia, but further research is needed to optimize management strategies for this rarity.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dragan Djurdjevic, Aleksandra Nikolic, Sanja Mazic, Sandra Sipetic-Grujicic
Background/Aim. Insufficient levels of physical activity and poor nutrition, have led to an increase in the number of obese adolescents and cardiometabolic problems. The aim of this study was to analyze association between eating habits and low physical activity level among adolescents. Methods. The cross-sectional study was conducted during May 2017. The study included a total of 389 participants, aged 15-19 years. The study instrument was a questionnaire regarding demographic characteristics, physical activity (International Physical Activity Questionnaire-Short Form), as well as eating habits. The data were analyzed using univariate and multivariate logistic regression analysis. Results. A total of 131 participants (33.7%) had low level of physical activity, 258 (66.3%) had moderate/high level of physical activity. Adolescents with moderate/high physical activity were significantly more likely to be male and medical school students. Also, they had breakfast significantly more often, consumed fish more than twice a week, or at least twice a week, and ate fruit once or more a day and generally ate healthy, compared to high school students with low physical activity. Among the factors that were associated with low physical activity were the following: the female gender, eating breakfast never/sometimes, consuming fish less than twice a week, fruit less than once a day, maintaining a healthy diet, and adolescents aged 17-19 years. Conclusion. This study identified several statistically significant independent factors associated with low physical activity in adolescents. Based on the obtained results, it is necessary to undertake certain interventions, promote physical activity, correct eating habits, and the overall lifestyle, with a special emphasis on the female population and children aged 18-19. The education of both adolescents and parents is very important.
{"title":"Association between eating habits and low physical activity in adolescents","authors":"Dragan Djurdjevic, Aleksandra Nikolic, Sanja Mazic, Sandra Sipetic-Grujicic","doi":"10.2298/vsp230131058d","DOIUrl":"https://doi.org/10.2298/vsp230131058d","url":null,"abstract":"Background/Aim. Insufficient levels of physical activity and poor nutrition, have led to an increase in the number of obese adolescents and cardiometabolic problems. The aim of this study was to analyze association between eating habits and low physical activity level among adolescents. Methods. The cross-sectional study was conducted during May 2017. The study included a total of 389 participants, aged 15-19 years. The study instrument was a questionnaire regarding demographic characteristics, physical activity (International Physical Activity Questionnaire-Short Form), as well as eating habits. The data were analyzed using univariate and multivariate logistic regression analysis. Results. A total of 131 participants (33.7%) had low level of physical activity, 258 (66.3%) had moderate/high level of physical activity. Adolescents with moderate/high physical activity were significantly more likely to be male and medical school students. Also, they had breakfast significantly more often, consumed fish more than twice a week, or at least twice a week, and ate fruit once or more a day and generally ate healthy, compared to high school students with low physical activity. Among the factors that were associated with low physical activity were the following: the female gender, eating breakfast never/sometimes, consuming fish less than twice a week, fruit less than once a day, maintaining a healthy diet, and adolescents aged 17-19 years. Conclusion. This study identified several statistically significant independent factors associated with low physical activity in adolescents. Based on the obtained results, it is necessary to undertake certain interventions, promote physical activity, correct eating habits, and the overall lifestyle, with a special emphasis on the female population and children aged 18-19. The education of both adolescents and parents is very important.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135010274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tatjana Radevic, Zeljko Mijuskovic, Lidija Kandolf
Background/Aim. Subcorneal pustular dermatosis (SPD) is a rare, relapsing vesiculopustular disease, predominantly presenting on the flexor surfaces. In this study, clinical features and long-term follow-up data on patients with SPD were analyzed, since data about the course and duration of the disease is limited. Methods. A hospital database was searched for medical records of patients with SPD evaluated at the institution between 1985 and 2014. The focus was on clinical characteristics, associated diseases, the disease courses and outcomes. Results. Seventeen patients with clinical features of SPD were analyzed: nine females and eight males with a median age at presentation of 45 years (18-90). Follow-up data were available for 12 patients; the median time of follow-up was 9.5 years (1-28 years). Repeated biopsies (mean 1.7 biopsies per patient) were needed to establish histological diagnosis. In one male patient, IgA pemphigus was diagnosed by direct immunofluorescence. In most patients, skin eruption was widespread; in the minority, it was present only on flexor surfaces. Dysproteinemia was evident in three patients with SPD. The disease was self-limiting in three patients; five patients had mild flare-ups occurring 1-3 times a year without the need for treatment; four patients had continuous flare-ups requiring treatment. SPD responded favorably to dapsone in the majority of our patients. Conclusion. SPD is rare disease that usually occur in a person?s fifth decade. While it is self-limiting in some patients, approximately one-third of patients require continuous therapy for continuous flareups.
{"title":"Subcorneal pustular dermatosis: Clinical characteristics and long-term follow-up of seventeen patients","authors":"Tatjana Radevic, Zeljko Mijuskovic, Lidija Kandolf","doi":"10.2298/vsp230830064r","DOIUrl":"https://doi.org/10.2298/vsp230830064r","url":null,"abstract":"Background/Aim. Subcorneal pustular dermatosis (SPD) is a rare, relapsing vesiculopustular disease, predominantly presenting on the flexor surfaces. In this study, clinical features and long-term follow-up data on patients with SPD were analyzed, since data about the course and duration of the disease is limited. Methods. A hospital database was searched for medical records of patients with SPD evaluated at the institution between 1985 and 2014. The focus was on clinical characteristics, associated diseases, the disease courses and outcomes. Results. Seventeen patients with clinical features of SPD were analyzed: nine females and eight males with a median age at presentation of 45 years (18-90). Follow-up data were available for 12 patients; the median time of follow-up was 9.5 years (1-28 years). Repeated biopsies (mean 1.7 biopsies per patient) were needed to establish histological diagnosis. In one male patient, IgA pemphigus was diagnosed by direct immunofluorescence. In most patients, skin eruption was widespread; in the minority, it was present only on flexor surfaces. Dysproteinemia was evident in three patients with SPD. The disease was self-limiting in three patients; five patients had mild flare-ups occurring 1-3 times a year without the need for treatment; four patients had continuous flare-ups requiring treatment. SPD responded favorably to dapsone in the majority of our patients. Conclusion. SPD is rare disease that usually occur in a person?s fifth decade. While it is self-limiting in some patients, approximately one-third of patients require continuous therapy for continuous flareups.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135316838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nemanja Stevanovic, Aljosa Mandic, Slobodan Maricic, Gabriel Nadj, Tamara Maksimovic, Nevena Stanulovic, Vladimir Cancar, Milan Rodic
Background/Aim. Carcinosarcoma of the uterus, formerly known as malignant mixed M?llerian tumor, is a rare, aggressive malignancy of the female genital tract. The aim of this study was to analyse most important clinical and pathohistological characteristics of carcinosarcomas on operated patients, as well as to determine which of those factors are affecting disease free survival and overall survival of patients. Methods. The study was conducted as a retrospective analysis of medical data documentation of patients with a diagnosis of carcinosarcoma of the uterus who were surgically treated at Department of Gynecology, Clinic for Operative Oncology, Oncology Institute of Vojvodina, Sremska Kamenica, Serbia, in a period of 10 years, from the beginning of 2009 to the end of 2018. Results. The analysis included data for a total of 31 patients. Of all the examined parameters (age of the patient, clinical stage of the disease, histological grade, depth of myometrial invasion and lymphovascular invasion) the greatest influence on the choice of therapeutic procedure had a histological tumor grade. Conclusion. Our research showed the joint influence of the examined clinical and pathohistological factors parameters on progressionfree survival (PFS) and overall survival (OS) of patients with carcinosarcoma of the uterus. The only independent parameter that showed statistically significant impact on survival is lymphovascular invasion.
{"title":"Survival analysis of patients with rare tumors of the uterine corpus – carcinosarcoma","authors":"Nemanja Stevanovic, Aljosa Mandic, Slobodan Maricic, Gabriel Nadj, Tamara Maksimovic, Nevena Stanulovic, Vladimir Cancar, Milan Rodic","doi":"10.2298/vsp230901063s","DOIUrl":"https://doi.org/10.2298/vsp230901063s","url":null,"abstract":"Background/Aim. Carcinosarcoma of the uterus, formerly known as malignant mixed M?llerian tumor, is a rare, aggressive malignancy of the female genital tract. The aim of this study was to analyse most important clinical and pathohistological characteristics of carcinosarcomas on operated patients, as well as to determine which of those factors are affecting disease free survival and overall survival of patients. Methods. The study was conducted as a retrospective analysis of medical data documentation of patients with a diagnosis of carcinosarcoma of the uterus who were surgically treated at Department of Gynecology, Clinic for Operative Oncology, Oncology Institute of Vojvodina, Sremska Kamenica, Serbia, in a period of 10 years, from the beginning of 2009 to the end of 2018. Results. The analysis included data for a total of 31 patients. Of all the examined parameters (age of the patient, clinical stage of the disease, histological grade, depth of myometrial invasion and lymphovascular invasion) the greatest influence on the choice of therapeutic procedure had a histological tumor grade. Conclusion. Our research showed the joint influence of the examined clinical and pathohistological factors parameters on progressionfree survival (PFS) and overall survival (OS) of patients with carcinosarcoma of the uterus. The only independent parameter that showed statistically significant impact on survival is lymphovascular invasion.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135213092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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