Snezana Djukic, Aleksandar Pavlovic, Aleksandra Ilic, Aleksandar Bozovic, Gojko Igrutinovic, Miljana Nikolic, Mirjana Vujacic, Ivan Stanojevic
Background/Aim. The role of the complex sepsis-related immune response has not been fully clarified, and still remains a subject matter of investigations. Nowadays, sepsis is considered a dynamic syndrome characterised by many, often antagonistic, phenomena from hyperinflammation to anergy, or immunoparalysis. On the basis of pro- and anti-inflammatory mediators in the critically ill with sepsis, the aim of the study was to determine whether the cytokine profile differs according to the type of bacterial causative agent, as well as to assess the prognostic value regarding the outcome. The outcome measure has been hospital mortality. Methods. Blood serum samples have been taken from 125 critically ill patients with severe secondary sepsis as a consequence of peritonitis, pancreatitis, or trauma, who had been admitted to the surgical intensive care unit (SICU). The average age of the patients was 57.7?17.3. Of the total number of patients, 84 (67,2%) were males, and 41 (32,8%) were females. The levels of pro-inflammatory ? interleukin 1-alpha (IL-1?), IL-1?, IL-6, IL-8, IL-12?70, IL-17?, tumor necrosis factor alpha (TNF?), interferon-gamma (IFN-?), interferon-gamma-inducible protein-10 (IP 10), monocyte chemoattractant protein-1(MCP-1), macrophage inflammatory protein alpha and beta (MIP-1? and MIP-1?), as well as anti-inflammatory mediators IL-4, IL-10, IL-13, IL-27, IL-31 and IL-33 were determined at three time intervals - on the day of admission (the first day), and then on the third and fifth day. Through standard microbiological analyses, the type of the bacterial causative agent has been determined. Results. On the third day of measurement, significant differences in the cytokine levels with regard to the nature of bacteremia were determined in all pro- and anti-inflammatory cytokines, except for IL-8. Generally, the lowest levels were observed in patients with polymicrobial blood culture. On the first and fifth days of measurement, no significant differences in the cytokine levels with regard to the nature of bacteriemia was found. The only significant predictor of the lethal outcome on the first measurement day was IL-17?, AUR ROC of 0,665 (95% confidence interval of 0,519-0,791, ?=0.034) with secondary sepsis as a complication of peritonitis. Conclusion. According to the type of the bacterial causative agent, the lowest levels of cytokines have been observed in patients with the polymicrobial blood culture. IL- 17? is a good predictor of the outcome in patients with peritonitis as an underlying condition of secondary sepsis. The low level of IL-17? in these patients predicted a lethal outcome on the first day of measurement. On the other hand, the levels of other cytokines correlated with the outcome only on the fifth day of measurement, and they were higher in survivors than in non-survivors.
{"title":"Cytokine profile in critically ill and/or injured patients with secondary sepsis - influence of different pathogens","authors":"Snezana Djukic, Aleksandar Pavlovic, Aleksandra Ilic, Aleksandar Bozovic, Gojko Igrutinovic, Miljana Nikolic, Mirjana Vujacic, Ivan Stanojevic","doi":"10.2298/vsp230105054d","DOIUrl":"https://doi.org/10.2298/vsp230105054d","url":null,"abstract":"Background/Aim. The role of the complex sepsis-related immune response has not been fully clarified, and still remains a subject matter of investigations. Nowadays, sepsis is considered a dynamic syndrome characterised by many, often antagonistic, phenomena from hyperinflammation to anergy, or immunoparalysis. On the basis of pro- and anti-inflammatory mediators in the critically ill with sepsis, the aim of the study was to determine whether the cytokine profile differs according to the type of bacterial causative agent, as well as to assess the prognostic value regarding the outcome. The outcome measure has been hospital mortality. Methods. Blood serum samples have been taken from 125 critically ill patients with severe secondary sepsis as a consequence of peritonitis, pancreatitis, or trauma, who had been admitted to the surgical intensive care unit (SICU). The average age of the patients was 57.7?17.3. Of the total number of patients, 84 (67,2%) were males, and 41 (32,8%) were females. The levels of pro-inflammatory ? interleukin 1-alpha (IL-1?), IL-1?, IL-6, IL-8, IL-12?70, IL-17?, tumor necrosis factor alpha (TNF?), interferon-gamma (IFN-?), interferon-gamma-inducible protein-10 (IP 10), monocyte chemoattractant protein-1(MCP-1), macrophage inflammatory protein alpha and beta (MIP-1? and MIP-1?), as well as anti-inflammatory mediators IL-4, IL-10, IL-13, IL-27, IL-31 and IL-33 were determined at three time intervals - on the day of admission (the first day), and then on the third and fifth day. Through standard microbiological analyses, the type of the bacterial causative agent has been determined. Results. On the third day of measurement, significant differences in the cytokine levels with regard to the nature of bacteremia were determined in all pro- and anti-inflammatory cytokines, except for IL-8. Generally, the lowest levels were observed in patients with polymicrobial blood culture. On the first and fifth days of measurement, no significant differences in the cytokine levels with regard to the nature of bacteriemia was found. The only significant predictor of the lethal outcome on the first measurement day was IL-17?, AUR ROC of 0,665 (95% confidence interval of 0,519-0,791, ?=0.034) with secondary sepsis as a complication of peritonitis. Conclusion. According to the type of the bacterial causative agent, the lowest levels of cytokines have been observed in patients with the polymicrobial blood culture. IL- 17? is a good predictor of the outcome in patients with peritonitis as an underlying condition of secondary sepsis. The low level of IL-17? in these patients predicted a lethal outcome on the first day of measurement. On the other hand, the levels of other cytokines correlated with the outcome only on the fifth day of measurement, and they were higher in survivors than in non-survivors.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136006021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marija Trenkic, Tatjana Jevtovic-Stoimenov, Jelena Basic, Jelena Vasilijevic, Dragana Ristic, Milan Trenkic, Aleksandar Veselinovic, Marija Cvetanovic
Background/Aim. Changes in the concentration of various mediators of inflammation and immune response in blood, aqueous humor, or eye tissues support the theory of inflammation and immune system activity in the pathogenesis of openangle glaucoma. Inflammatory biomarkers have a great potential for application in clinical practice. We investigated the plasma concentrations of tumor necrosis factor alpha (TNF-?) in patients with open-angle glaucoma and controls without glaucoma, and examined a correlation between plasma TNF-? levels in glaucoma patients and their clinical parameters. Methods. The present study included 87 participants (87 eyes) divided into three groups: 35 subjects (35 eyes) with primary open-angle glaucoma with elevated intraocular pressure - hypertension glaucoma (POAG-HTG), 23 subjects (23 eyes) with pseudoexfoliative open-angle glaucoma (XFG), and 29 subjects in the control group matched with the patient groups in terms of age and sex. We performed a complete clinical examination including standard automated perimetry and determination of changes in the participant's repeated visual field, and optical coherence tomography and determination of retinal peripapillary nerve fiber thickness (RNFL). The concentration of circulating TNF-? in participants? plasma was measured using commercial immunoadsorption enzyme tests (ELISA). Results. The concentrations of TNF-? in the plasma of glaucoma patients (POAG-HTG 2.04?1.98 pg/mL and XFG 2.05?1.48 pg/mL) were significantly higher than in healthy subjects (1.43?2.00 pg/mL, p<0.05). No statistically significant correlations of TNF-? concentration with any of the clinical parameters including IOP, C/D, MD, RNFL Avg, RNFL Sup and RNFL Inf were found in any of the groups of patients with glaucoma. Conclusion. The concentration of the pro-inflammatory cytokine, TNF-?, in the plasma is significantly higher in glaucoma patients compared to nonglaucomatous subjects, and confirms the role of the inflammation in the pathogenesis of glaucoma, as one of noninflammatory ocular diseases. The plasma concentration of TNF-? does not correlate with any of the examined clinical parameters; hence, it cannot be considered a measure of progression and damage in glaucoma.
{"title":"Increased concentration of tumour necrosis factor alpha in the plasma of glaucoma patients","authors":"Marija Trenkic, Tatjana Jevtovic-Stoimenov, Jelena Basic, Jelena Vasilijevic, Dragana Ristic, Milan Trenkic, Aleksandar Veselinovic, Marija Cvetanovic","doi":"10.2298/vsp230725062t","DOIUrl":"https://doi.org/10.2298/vsp230725062t","url":null,"abstract":"Background/Aim. Changes in the concentration of various mediators of inflammation and immune response in blood, aqueous humor, or eye tissues support the theory of inflammation and immune system activity in the pathogenesis of openangle glaucoma. Inflammatory biomarkers have a great potential for application in clinical practice. We investigated the plasma concentrations of tumor necrosis factor alpha (TNF-?) in patients with open-angle glaucoma and controls without glaucoma, and examined a correlation between plasma TNF-? levels in glaucoma patients and their clinical parameters. Methods. The present study included 87 participants (87 eyes) divided into three groups: 35 subjects (35 eyes) with primary open-angle glaucoma with elevated intraocular pressure - hypertension glaucoma (POAG-HTG), 23 subjects (23 eyes) with pseudoexfoliative open-angle glaucoma (XFG), and 29 subjects in the control group matched with the patient groups in terms of age and sex. We performed a complete clinical examination including standard automated perimetry and determination of changes in the participant's repeated visual field, and optical coherence tomography and determination of retinal peripapillary nerve fiber thickness (RNFL). The concentration of circulating TNF-? in participants? plasma was measured using commercial immunoadsorption enzyme tests (ELISA). Results. The concentrations of TNF-? in the plasma of glaucoma patients (POAG-HTG 2.04?1.98 pg/mL and XFG 2.05?1.48 pg/mL) were significantly higher than in healthy subjects (1.43?2.00 pg/mL, p<0.05). No statistically significant correlations of TNF-? concentration with any of the clinical parameters including IOP, C/D, MD, RNFL Avg, RNFL Sup and RNFL Inf were found in any of the groups of patients with glaucoma. Conclusion. The concentration of the pro-inflammatory cytokine, TNF-?, in the plasma is significantly higher in glaucoma patients compared to nonglaucomatous subjects, and confirms the role of the inflammation in the pathogenesis of glaucoma, as one of noninflammatory ocular diseases. The plasma concentration of TNF-? does not correlate with any of the examined clinical parameters; hence, it cannot be considered a measure of progression and damage in glaucoma.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"149 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135213346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vanja Dimitrijević, Ivana Todorovic, Biljana Viduka, Igor Lavrnić, D. Viduka
Background/Aim. The visual and health problems associated with the use of computers and other digital devices are known as Computer Vision Syndrome (CVS). Advances in technology has led to increased use of computers so the prevalence of these symptoms is increasing. The aim of this study was to calculate the overall prevalence of CVS and CVS symptoms using meta-analysis. Methods. This study has been developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. Four databases were searched for articles collection: PubMed, Cochrane Library, Web of Science, and Google Scholar were searched. The key search terms were: Computer vision syndrome, computer users, digital eyestrain, headache, dry eyes, red eyes, eyestrain, neck pain, back pain, and shoulder pain. The articles included in our study were limited to original articles written only in English that met the following inclusion criteria: 1) the research had to include computer users; 2) as a result, the prevalence of CVS or the prevalence of any of the symptoms of CVS had to be measured. Results. A systematic search of four electronic databases was conducted on July 2021. 43 articles were fully reviewed and 20 of them were included in the meta-analysis. The total overall prevalence for all studies was calculated to be 74.4%, while the prevalence for individual symptoms was: headache at 43%, dry eyes at 24.4%, eyestrain at 29%, red eyes at 20.7%, and neck, back, or shoulder pain at 46.3%. Conclusion. The results obtained are worrying and point to a necessity of multidisciplinary approach to solving CVS-related problems.
背景/目的。与使用计算机和其他数字设备相关的视觉和健康问题被称为计算机视觉综合征(CVS)。科技的进步导致电脑使用的增加，因此这些症状的患病率也在增加。本研究的目的是使用荟萃分析计算CVS的总体患病率和CVS症状。方法。本研究是根据系统评价和荟萃分析的首选报告项目(PRISMA)声明进行的。检索了四个数据库:PubMed、Cochrane Library、Web of Science和谷歌Scholar。关键搜索词是:电脑视觉综合症，电脑使用者，数码眼疲劳，头痛，眼睛干涩，眼睛发红，眼疲劳，颈部疼痛，背部疼痛和肩部疼痛。本研究纳入的文章仅限于满足以下纳入标准的纯英文原创文章:1)研究必须包括计算机用户;2)因此，必须测量CVS的患病率或任何CVS症状的患病率。结果。2021年7月对四个电子数据库进行了系统检索。43篇文章被全面审查，其中20篇被纳入meta分析。所有研究的总总患病率计算为74.4%，而个别症状的患病率为:头痛占43%，眼睛干涩占24.4%，眼疲劳占29%，眼睛发红占20.7%，颈、背或肩痛占46.3%。结论。获得的结果令人担忧，并指出解决cvs相关问题的多学科方法的必要性。
{"title":"Prevalence of computer vision syndrome in computer users: A systematic review and meta-analysis","authors":"Vanja Dimitrijević, Ivana Todorovic, Biljana Viduka, Igor Lavrnić, D. Viduka","doi":"10.2298/vsp220301024d","DOIUrl":"https://doi.org/10.2298/vsp220301024d","url":null,"abstract":"Background/Aim. The visual and health problems associated with the use of computers and other digital devices are known as Computer Vision Syndrome (CVS). Advances in technology has led to increased use of computers so the prevalence of these symptoms is increasing. The aim of this study was to calculate the overall prevalence of CVS and CVS symptoms using meta-analysis. Methods. This study has been developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. Four databases were searched for articles collection: PubMed, Cochrane Library, Web of Science, and Google Scholar were searched. The key search terms were: Computer vision syndrome, computer users, digital eyestrain, headache, dry eyes, red eyes, eyestrain, neck pain, back pain, and shoulder pain. The articles included in our study were limited to original articles written only in English that met the following inclusion criteria: 1) the research had to include computer users; 2) as a result, the prevalence of CVS or the prevalence of any of the symptoms of CVS had to be measured. Results. A systematic search of four electronic databases was conducted on July 2021. 43 articles were fully reviewed and 20 of them were included in the meta-analysis. The total overall prevalence for all studies was calculated to be 74.4%, while the prevalence for individual symptoms was: headache at 43%, dry eyes at 24.4%, eyestrain at 29%, red eyes at 20.7%, and neck, back, or shoulder pain at 46.3%. Conclusion. The results obtained are worrying and point to a necessity of multidisciplinary approach to solving CVS-related problems.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68337985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tina Pajević, Dina Vasović, J. Juloski, L. Vucić, B. Glišić
Background/Aim. An impacted tooth is a tooth that could not erupt and take its place in the dental row. Impacted maxillary canines are a very frequent problem in the orthodontic practices. They are the second most impacted teeth, right after the third molars. The aim of this cross-sectional study was to evaluate the two-dimensional and three-dimensional position of the impacted maxillary canines as well as to make a descriptive study analysis of possible indicators of the impaction difficulty and risk factors for adjacent tooth root resorption. Methods. 94 subjects with 116 diagnosed maxillary canines impaction (CI) were included in the investigation. The two-dimensional position of the impacted canines (IC) was evaluated on the panoramic projection of the cone beam computed tomography (CBCT) images. Canine position (CP) to the X, Y and Z-axis was measured and scored using the novel classification system that incorporates three-dimensional information of CBCT imaging, the KPG index. Based on the KPG index value, impaction was defined as easy, moderate, difficult, and extremely difficult. Descriptive variables (gender, side of impaction, etc.) and numeric variables [age, canine distance to the occlusal plane (OccP), etc.] were tested with multiple logistic regression as potential predictors of the impaction difficulty and possible risk factors. Results. The mean age of the subjects was 19.8?5.2 years. The impactions were twice as more prevalent in females, compared to males. Most impactions were unilateral (71.4%) in palatal position. Adjacent root resorption was present in 27.3% cases of impaction, and the central incisor was mostly affected. More than half of impactions were of moderate level. In univariable analysis, canine distance to sagittal medial line (SML), canine angulation (CA) to SML and OccP and CA to first premolar were significant in impaction difficulty prediction. Multivariable analysis showed that CA to the first premolar could be a risk factor for adjacent root resorption. Conclusion. Most of the impacted maxillary canines were in palatal position, with KPG index value of moderate difficulty. Beside the position to the OccP and SML, CA to the first premolar should be estimated, as a part of diagnostic procedures, to evaluate the risk of adjacent root resorption, to prevent resorption and to decide on the treatment plan.
{"title":"Evaluation of the impacted maxillary canines position, determination of the possible indicators of the impaction difficulty and the risk factors for adjacent teeth root resorption","authors":"Tina Pajević, Dina Vasović, J. Juloski, L. Vucić, B. Glišić","doi":"10.2298/vsp220329010p","DOIUrl":"https://doi.org/10.2298/vsp220329010p","url":null,"abstract":"Background/Aim. An impacted tooth is a tooth that could not erupt and take its place in the dental row. Impacted maxillary canines are a very frequent problem in the orthodontic practices. They are the second most impacted teeth, right after the third molars. The aim of this cross-sectional study was to evaluate the two-dimensional and three-dimensional position of the impacted maxillary canines as well as to make a descriptive study analysis of possible indicators of the impaction difficulty and risk factors for adjacent tooth root resorption. Methods. 94 subjects with 116 diagnosed maxillary canines impaction (CI) were included in the investigation. The two-dimensional position of the impacted canines (IC) was evaluated on the panoramic projection of the cone beam computed tomography (CBCT) images. Canine position (CP) to the X, Y and Z-axis was measured and scored using the novel classification system that incorporates three-dimensional information of CBCT imaging, the KPG index. Based on the KPG index value, impaction was defined as easy, moderate, difficult, and extremely difficult. Descriptive variables (gender, side of impaction, etc.) and numeric variables [age, canine distance to the occlusal plane (OccP), etc.] were tested with multiple logistic regression as potential predictors of the impaction difficulty and possible risk factors. Results. The mean age of the subjects was 19.8?5.2 years. The impactions were twice as more prevalent in females, compared to males. Most impactions were unilateral (71.4%) in palatal position. Adjacent root resorption was present in 27.3% cases of impaction, and the central incisor was mostly affected. More than half of impactions were of moderate level. In univariable analysis, canine distance to sagittal medial line (SML), canine angulation (CA) to SML and OccP and CA to first premolar were significant in impaction difficulty prediction. Multivariable analysis showed that CA to the first premolar could be a risk factor for adjacent root resorption. Conclusion. Most of the impacted maxillary canines were in palatal position, with KPG index value of moderate difficulty. Beside the position to the OccP and SML, CA to the first premolar should be estimated, as a part of diagnostic procedures, to evaluate the risk of adjacent root resorption, to prevent resorption and to decide on the treatment plan.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68338317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Vlahović, Mila Živković, Velibor Majic, Zorka Badnjar-Ilic, N. Begović, I. Dizdarević
Introduction. Ectopic cervical thymus tissue results from incomplete migration of the thymic primordia during embryogenesis. It is asymptomatic in most of the cases, however, in 10% of patients there are different kind of symptoms. Case report. A 4-month-old boy was referred to our clinic, for the evaluation of a growing large neck mass on the right side that has been present since birth. Physical examination revealed a painless, soft, moderately mobile, and irregular round solid neck mass localized on the right side, in front of the sternocleidomastoid muscle, below the parotid gland, and above the carotid lodge. The mass was 40 x 32 x15 mm in diameter. Following the clinical, ultrasonographic and magnetic resonance imaging findings, we suspected that it was an ectopic cervical thymus. Surgical excision was done. The pathology report confirmed the presence of the ectopic cervical thymic tissue with Hassall?s corpuscles. The postoperative course was unremarkable and the wound healed well. Furthermore, clinical, immunological, and echography 6-month follow-up was unremarkable. Conclusion. The congenital cervical ectopic thymus is a rare congenital anomaly, however it should be considered in the differential diagnosis of neck masses.
{"title":"Solid ectopic cervical thymus in an infant: A case report","authors":"A. Vlahović, Mila Živković, Velibor Majic, Zorka Badnjar-Ilic, N. Begović, I. Dizdarević","doi":"10.2298/vsp221205020v","DOIUrl":"https://doi.org/10.2298/vsp221205020v","url":null,"abstract":"Introduction. Ectopic cervical thymus tissue results from incomplete migration of the thymic primordia during embryogenesis. It is asymptomatic in most of the cases, however, in 10% of patients there are different kind of symptoms. Case report. A 4-month-old boy was referred to our clinic, for the evaluation of a growing large neck mass on the right side that has been present since birth. Physical examination revealed a painless, soft, moderately mobile, and irregular round solid neck mass localized on the right side, in front of the sternocleidomastoid muscle, below the parotid gland, and above the carotid lodge. The mass was 40 x 32 x15 mm in diameter. Following the clinical, ultrasonographic and magnetic resonance imaging findings, we suspected that it was an ectopic cervical thymus. Surgical excision was done. The pathology report confirmed the presence of the ectopic cervical thymic tissue with Hassall?s corpuscles. The postoperative course was unremarkable and the wound healed well. Furthermore, clinical, immunological, and echography 6-month follow-up was unremarkable. Conclusion. The congenital cervical ectopic thymus is a rare congenital anomaly, however it should be considered in the differential diagnosis of neck masses.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Veličković, Stevo Matijević, Bojan Jovičić, M. Bubalo, Momir Stevanović, M. Vasovic
Background/Aim. A lingual foramen (LF) is a small opening on the lingual surface of the mandible, which is most frequently located in the middle of the anterior part of the mandible and which shows significant variations in its location, size and number. The aim of this study was to assess the location and anatomical characteristics of LF using cone beam computed tomography (CBCT). Methods. The research was designed as a retrospective study in which 99 CBCT scans were analysed. The analysis covered the number of LF, their location in relation to the teeth and the mandibular region itself, diameter, distance from the alveolar ridge crest, distance from the inferior border of the mandible, distance from the tooth apex and position in relation to the tooth apex. Results. The average frequency of LF per patient was 2.4 1.2. The largest number of LF were localised in the region of lower central incisors. Out of the total number of LF, 82.5% of LF belonged to median lingual foramen (MLF), while 17.5% belonged to lateral lingual foramen (LLF). In 63.2% cases, LF had a diameter of ?1mm, whereas in 98.3% cases it was localised below the tooth apex. There is a statistically significant difference in the distance of LF from the alveolar ridge crest and the LF diameter in relation to gender (p = 0.019; p = 0.008). Conclusion. LF can be reliably localised and visualised by means of CBCT. It is recommended that CBCT scanning of the mandible should be used while planning an oral surgical procedure and implant placement in order to prevent injuries of the neurovascular bundle which passes through LF.
{"title":"Assessment of location and anatomical characteristics of lingual foramen using cone beam computed tomography","authors":"S. Veličković, Stevo Matijević, Bojan Jovičić, M. Bubalo, Momir Stevanović, M. Vasovic","doi":"10.2298/vsp221208009v","DOIUrl":"https://doi.org/10.2298/vsp221208009v","url":null,"abstract":"Background/Aim. A lingual foramen (LF) is a small opening on the lingual surface of the mandible, which is most frequently located in the middle of the anterior part of the mandible and which shows significant variations in its location, size and number. The aim of this study was to assess the location and anatomical characteristics of LF using cone beam computed tomography (CBCT). Methods. The research was designed as a retrospective study in which 99 CBCT scans were analysed. The analysis covered the number of LF, their location in relation to the teeth and the mandibular region itself, diameter, distance from the alveolar ridge crest, distance from the inferior border of the mandible, distance from the tooth apex and position in relation to the tooth apex. Results. The average frequency of LF per patient was 2.4 1.2. The largest number of LF were localised in the region of lower central incisors. Out of the total number of LF, 82.5% of LF belonged to median lingual foramen (MLF), while 17.5% belonged to lateral lingual foramen (LLF). In 63.2% cases, LF had a diameter of ?1mm, whereas in 98.3% cases it was localised below the tooth apex. There is a statistically significant difference in the distance of LF from the alveolar ridge crest and the LF diameter in relation to gender (p = 0.019; p = 0.008). Conclusion. LF can be reliably localised and visualised by means of CBCT. It is recommended that CBCT scanning of the mandible should be used while planning an oral surgical procedure and implant placement in order to prevent injuries of the neurovascular bundle which passes through LF.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanja Tirnanić, T. Radevic, Andrea Djordjevic, N. Petrov, Z. Mijuskovic
Introduction. Pancreatic panniculitis is a rare type of lobular panniculitis that manifests as painful erythematous nodules on the skin of the lower extremities. Subcutaneous fat necrosis caused by the release of pancreatic enzymes is the underlying cause of the disease, affecting around 2 to 3% of patients with pancreatic diseases. Case report. We present a case of a 58-year-old male patient who exhibited painful erythematous nodules on the lower extremities and trunk. Laboratory results revealed increased levels of pancreatic enzymes, amylase, and lipase, as well as heightened levels of glucose and inflammation markers. The histological analysis of the skin lesion biopsy revealed the presence of predominantly lobular panniculitis in the hypodermis, areas of fatty tissue necrosis/saponification, and remnants of adipocytes (??ghost cells??). Abdominal CT scan demonstrated periampullary diverticulum of the duodenum, with no signs of pancreatitis or other pancreatic abnormalities. Esophagogastroduodenoscopy showed a wide opening of the periampullary diverticulum in the D2 segment of the duodenum. The patient was successfully treated with pancreatin therapy, resulting in a significant reduction of skin lesions and decreased levels of pancreatic enzymes. Conclusion. Pancreatic panniculitis can be caused by periampullary duodenal diverticula that exert pressure on the pancreatic duct, leading to elevated levels of pancreatic enzymes. Symptomatic duodenal diverticula may be treated with operative or non-operative measures, depending on the individual characteristics of the patient. Treatment of pancreatic panniculitis primarily involves addressing any underlying medical condition.
{"title":"Pancreatic panniculitis associated with periampullary duodenal diverticulum: A case report","authors":"Tanja Tirnanić, T. Radevic, Andrea Djordjevic, N. Petrov, Z. Mijuskovic","doi":"10.2298/vsp230626043t","DOIUrl":"https://doi.org/10.2298/vsp230626043t","url":null,"abstract":"Introduction. Pancreatic panniculitis is a rare type of lobular panniculitis that manifests as painful erythematous nodules on the skin of the lower extremities. Subcutaneous fat necrosis caused by the release of pancreatic enzymes is the underlying cause of the disease, affecting around 2 to 3% of patients with pancreatic diseases. Case report. We present a case of a 58-year-old male patient who exhibited painful erythematous nodules on the lower extremities and trunk. Laboratory results revealed increased levels of pancreatic enzymes, amylase, and lipase, as well as heightened levels of glucose and inflammation markers. The histological analysis of the skin lesion biopsy revealed the presence of predominantly lobular panniculitis in the hypodermis, areas of fatty tissue necrosis/saponification, and remnants of adipocytes (??ghost cells??). Abdominal CT scan demonstrated periampullary diverticulum of the duodenum, with no signs of pancreatitis or other pancreatic abnormalities. Esophagogastroduodenoscopy showed a wide opening of the periampullary diverticulum in the D2 segment of the duodenum. The patient was successfully treated with pancreatin therapy, resulting in a significant reduction of skin lesions and decreased levels of pancreatic enzymes. Conclusion. Pancreatic panniculitis can be caused by periampullary duodenal diverticula that exert pressure on the pancreatic duct, leading to elevated levels of pancreatic enzymes. Symptomatic duodenal diverticula may be treated with operative or non-operative measures, depending on the individual characteristics of the patient. Treatment of pancreatic panniculitis primarily involves addressing any underlying medical condition.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Balint, M. Pavlovic, D. Abazovic, Sanja Toroman, Radica Grubovic-Rastvorceva, Marija Dinic, M. Todorovic-Balint
nema
nema
{"title":"Cellular cryobiology - a review of basic concepts and \"operating-design\" of cryopreserved cells","authors":"B. Balint, M. Pavlovic, D. Abazovic, Sanja Toroman, Radica Grubovic-Rastvorceva, Marija Dinic, M. Todorovic-Balint","doi":"10.2298/vsp230711044b","DOIUrl":"https://doi.org/10.2298/vsp230711044b","url":null,"abstract":"<jats:p>nema</jats:p>","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhijit Deshpande, Anita Pesic, Ole Boe, Andrzej Piotrowski, Samir Rawat
nema
尼玛
{"title":"Psychologists as emergency first responders during pandemic","authors":"Abhijit Deshpande, Anita Pesic, Ole Boe, Andrzej Piotrowski, Samir Rawat","doi":"10.2298/vsp230202055d","DOIUrl":"https://doi.org/10.2298/vsp230202055d","url":null,"abstract":"nema","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136005541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandar Kamenov, Vladimir Stojiljkovic, Aleksandar Petrovic, Milan Lazarevic, Mladjan Golubovic, Velimir Peric, Marija Stosic, Goran Radenkovic, Ivan Nikolic, Vladimir Petrovic, Sasa Zivic, Dragan Milic
Background/Aim. Taking in consideration the justified popularity of total arterial revascularization (TAR), the saphenous vein graft (SVG) is still one of the most utilized conduits in coronary artery bypass grafting (CABG). One of the determining factors of this conduit`s durability is its endothelial integrity at the time of surgery. The aim of the study was to investigate the effect of different storage solutions on SVG endothelial integrity in patients with diabetes mellitus (DM) type 2 and non-DM patients undergoing CABG. The solutions under evaluation were heparinized saline solution (0.9% NaCl), heparinized autologous whole blood, Bretschneider solution (HTK) and fresh frozen plasma solution (FFP). Methods. Forty patients were included in this study and were divided into two groups. Group A with 23 DM patients and group B with 17 non DM patients. The effects of these solutions were examined by immunohistochemical dyeing of CD34 antibodies and morphometric comparison in histologic samples of DM patients undergoing CABG between the 07.2021. and 09.2022. with samples provided by non-DM patients. Research was conducted in the facilities of the Cardiac Surgery Clinic, UCC Nis and the Department of Histology and Embryology Laboratory. Results. In this study the FFP solution showed the most prominent positive effect on preservation of Saphenous Venous Graft (SVG) endothelial integrity with the average cell integrity preservation of 92.20%. Bretschneider's solution was found to be the least effective with an endothelial cell preservation integrity of 26.77%. There was no marked no statistically significant difference in results from group A and B. Conclusion. There was a noticeable contrast in preserving SVG endothelial integrity between the two patient groups, type 2 DM and non-DM patients, although it was not statistically significant. The storage solution with the most beneficial effect on SVG endothelial integrity preservation was the FFP solution when harvested via conventional open method in CABG.
{"title":"The effect of different types of storage solutions on saphenous vein endothelial integrity in diabetic patients undergoing CABG","authors":"Aleksandar Kamenov, Vladimir Stojiljkovic, Aleksandar Petrovic, Milan Lazarevic, Mladjan Golubovic, Velimir Peric, Marija Stosic, Goran Radenkovic, Ivan Nikolic, Vladimir Petrovic, Sasa Zivic, Dragan Milic","doi":"10.2298/vsp230312051k","DOIUrl":"https://doi.org/10.2298/vsp230312051k","url":null,"abstract":"Background/Aim. Taking in consideration the justified popularity of total arterial revascularization (TAR), the saphenous vein graft (SVG) is still one of the most utilized conduits in coronary artery bypass grafting (CABG). One of the determining factors of this conduit`s durability is its endothelial integrity at the time of surgery. The aim of the study was to investigate the effect of different storage solutions on SVG endothelial integrity in patients with diabetes mellitus (DM) type 2 and non-DM patients undergoing CABG. The solutions under evaluation were heparinized saline solution (0.9% NaCl), heparinized autologous whole blood, Bretschneider solution (HTK) and fresh frozen plasma solution (FFP). Methods. Forty patients were included in this study and were divided into two groups. Group A with 23 DM patients and group B with 17 non DM patients. The effects of these solutions were examined by immunohistochemical dyeing of CD34 antibodies and morphometric comparison in histologic samples of DM patients undergoing CABG between the 07.2021. and 09.2022. with samples provided by non-DM patients. Research was conducted in the facilities of the Cardiac Surgery Clinic, UCC Nis and the Department of Histology and Embryology Laboratory. Results. In this study the FFP solution showed the most prominent positive effect on preservation of Saphenous Venous Graft (SVG) endothelial integrity with the average cell integrity preservation of 92.20%. Bretschneider's solution was found to be the least effective with an endothelial cell preservation integrity of 26.77%. There was no marked no statistically significant difference in results from group A and B. Conclusion. There was a noticeable contrast in preserving SVG endothelial integrity between the two patient groups, type 2 DM and non-DM patients, although it was not statistically significant. The storage solution with the most beneficial effect on SVG endothelial integrity preservation was the FFP solution when harvested via conventional open method in CABG.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135649938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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