Pub Date : 2024-09-18DOI: 10.1101/2023.01.26.525731
Théo Crosson, Shreyas Bhat, Jo-Chiao Wang, Clara Salaun, Eleanne Fontaine, Katiane Roversi, Herbert Herzog, Moutih Rafei, Rikard Blunck, Sebastien Talbot
Nociceptor neurons play a crucial role in maintaining the body's homeostasis by detecting and responding to potential dangers in the environment. However, this function can be detrimental during allergic reactions, since vagal nociceptors can contribute to immune cell infiltration, bronchial hypersensitivity, and mucus imbalance, in addition to causing pain and coughing. Despite this, the specific mechanisms by which nociceptors acquire pro-inflammatory characteristics during allergic reactions are not yet fully understood. In this study, we aimed to investigate the molecular profile of airway nociceptor neurons during allergic airway inflammation and identify the signals driving such reprogramming. Using retrograde tracing and lineage reporting, we identified a unique class of inflammatory vagal nociceptor neurons that exclusively innervate the airways. In the ovalbumin mouse model of airway inflammation, these neurons undergo significant reprogramming characterized by the upregulation of the NPY receptor Npy1r. A screening of cytokines and neurotrophins revealed that IL-1β, IL-13 and BDNF drive part of this reprogramming. IL-13 triggered Npy1r overexpression in nociceptors via the JAK/STAT6 pathway. In parallel, sympathetic neurons and macrophages release NPY in the bronchoalveolar fluid of asthmatic mice, which limits the excitability of nociceptor neurons. Single-cell RNA sequencing of lung immune cells has revealed that a cell-specific knockout of Npy1r in nociceptor neurons in asthmatic mice leads to an increase in airway inflammation mediated by T cells. Opposite findings were observed in asthmatic mice in which nociceptor neurons were chemically ablated. In summary, allergic airway inflammation reprograms airway nociceptor neurons to acquire a pro-inflammatory phenotype, while a compensatory mechanism involving NPY1R limits nociceptor neurons' activity.
{"title":"Cytokines reprogram airway sensory neurons in asthma.","authors":"Théo Crosson, Shreyas Bhat, Jo-Chiao Wang, Clara Salaun, Eleanne Fontaine, Katiane Roversi, Herbert Herzog, Moutih Rafei, Rikard Blunck, Sebastien Talbot","doi":"10.1101/2023.01.26.525731","DOIUrl":"10.1101/2023.01.26.525731","url":null,"abstract":"<p><p>Nociceptor neurons play a crucial role in maintaining the body's homeostasis by detecting and responding to potential dangers in the environment. However, this function can be detrimental during allergic reactions, since vagal nociceptors can contribute to immune cell infiltration, bronchial hypersensitivity, and mucus imbalance, in addition to causing pain and coughing. Despite this, the specific mechanisms by which nociceptors acquire pro-inflammatory characteristics during allergic reactions are not yet fully understood. In this study, we aimed to investigate the molecular profile of airway nociceptor neurons during allergic airway inflammation and identify the signals driving such reprogramming. Using retrograde tracing and lineage reporting, we identified a unique class of inflammatory vagal nociceptor neurons that exclusively innervate the airways. In the ovalbumin mouse model of airway inflammation, these neurons undergo significant reprogramming characterized by the upregulation of the NPY receptor <i>Npy1r</i>. A screening of cytokines and neurotrophins revealed that IL-1β, IL-13 and BDNF drive part of this reprogramming. IL-13 triggered <i>Npy1r</i> overexpression in nociceptors via the JAK/STAT6 pathway. In parallel, sympathetic neurons and macrophages release NPY in the bronchoalveolar fluid of asthmatic mice, which limits the excitability of nociceptor neurons. Single-cell RNA sequencing of lung immune cells has revealed that a cell-specific knockout of Npy1r in nociceptor neurons in asthmatic mice leads to an increase in airway inflammation mediated by T cells. Opposite findings were observed in asthmatic mice in which nociceptor neurons were chemically ablated. In summary, allergic airway inflammation reprograms airway nociceptor neurons to acquire a pro-inflammatory phenotype, while a compensatory mechanism involving NPY1R limits nociceptor neurons' activity.</p>","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81638241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.1080/09507116.2024.2376187
S. Kannaiyan, S. Murugesan, Dhamotharakannan Thirumalaikannan, Balasubramanian Visvalingam, B. P. Nagasai
{"title":"Characteristics analysis and monitoring of friction stir welded dissimilar AA5083/AA6061-T6 using acoustic emission technique","authors":"S. Kannaiyan, S. Murugesan, Dhamotharakannan Thirumalaikannan, Balasubramanian Visvalingam, B. P. Nagasai","doi":"10.1080/09507116.2024.2376187","DOIUrl":"https://doi.org/10.1080/09507116.2024.2376187","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"23 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-17DOI: 10.1080/09507116.2024.2378818
Wenjun Qian
{"title":"Edge detection in x-ray images of drill mast welds based on an improved Scharr operator","authors":"Wenjun Qian","doi":"10.1080/09507116.2024.2378818","DOIUrl":"https://doi.org/10.1080/09507116.2024.2378818","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.1080/09507116.2024.2354262
Hongxiao Wang, Chunsheng Wang, Jiancai Di, Zhangqi Yan, Liguo Liu
{"title":"Experimentally validated numerical prediction of laser welding induced distortions of Al alloy parts for railcar body by inherent strain method combined with thermo-elastic-plastic FE model","authors":"Hongxiao Wang, Chunsheng Wang, Jiancai Di, Zhangqi Yan, Liguo Liu","doi":"10.1080/09507116.2024.2354262","DOIUrl":"https://doi.org/10.1080/09507116.2024.2354262","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-14DOI: 10.1080/09507116.2024.2349917
Kumud Ranjan, Sushovan Basak, Manoj Kr. Gopaliya
{"title":"Understanding of thermal behaviour in keyhole plasma arc welding process through numerical modelling–an overview","authors":"Kumud Ranjan, Sushovan Basak, Manoj Kr. Gopaliya","doi":"10.1080/09507116.2024.2349917","DOIUrl":"https://doi.org/10.1080/09507116.2024.2349917","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"89 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.1080/09507116.2024.2348008
Ebrahim Harati, Ehsan Harati, Uchenna Onochie
{"title":"Effect of post-weld heat treatment on mechanical and microstructural properties of high strength steel weld metal","authors":"Ebrahim Harati, Ehsan Harati, Uchenna Onochie","doi":"10.1080/09507116.2024.2348008","DOIUrl":"https://doi.org/10.1080/09507116.2024.2348008","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"106 s414","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.1080/09507116.2024.2342342
Payam Farhadipour, S. Dehghan, N. Barka, Asim Iltaf, Pedram Farhadipour
{"title":"A study on effect of laser overlay welding parameters of stainless steel 301 LN: tensile test, microstructure analysis and microhardness evaluation","authors":"Payam Farhadipour, S. Dehghan, N. Barka, Asim Iltaf, Pedram Farhadipour","doi":"10.1080/09507116.2024.2342342","DOIUrl":"https://doi.org/10.1080/09507116.2024.2342342","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140683850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.1080/09507116.2024.2342340
Pradip K. Gajjar, Bharat C. Khatri, Rajesh Jha
{"title":"Investigation of effect of post weld heat treatment on microhardness and microstructure of auto TIG welded stabilized SA213 TP347H weldments","authors":"Pradip K. Gajjar, Bharat C. Khatri, Rajesh Jha","doi":"10.1080/09507116.2024.2342340","DOIUrl":"https://doi.org/10.1080/09507116.2024.2342340","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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