Introduction: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with variable treatment responses. Identification of molecular biomarkers could personalize treatment and improve outcomes. Methods: A retrospective cohort study was conducted at a tertiary hospital in Singapore. Patients with HNSCC treated between 2018-2023 were included. Pretreatment tumor biopsies were analyzed for biomarker expression (PD-L1, EGFR, TP53, HPV status) using immunohistochemistry and PCR. Clinical data were collected from medical records. Treatment response, survival, and associations with biomarkers were analyzed. Results: 250 patients were included. PD-L1 expression was associated with improved response to immunotherapy (p = 0.02). EGFR overexpression correlated with worse overall survival (p = 0.01). TP53 mutations were linked to increased locoregional recurrence (p = 0.03). HPV-positive tumors had a better prognosis (p < 0.001). Conclusion: Molecular biomarkers show promise in predicting treatment response and survival in HNSCC. Integration of these markers into clinical practice could facilitate personalized treatment strategies.
{"title":"Molecular Biomarkers as Predictors of Treatment Response and Survival Outcomes in Head and Neck Squamous Cell Carcinoma: A Retrospective Cohort Study at a Singapore Tertiary Hospital","authors":"Martin Curtis Lee, Nazilah Amir","doi":"10.59345/sjorl.v2i1.151","DOIUrl":"https://doi.org/10.59345/sjorl.v2i1.151","url":null,"abstract":"Introduction: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with variable treatment responses. Identification of molecular biomarkers could personalize treatment and improve outcomes. \u0000Methods: A retrospective cohort study was conducted at a tertiary hospital in Singapore. Patients with HNSCC treated between 2018-2023 were included. Pretreatment tumor biopsies were analyzed for biomarker expression (PD-L1, EGFR, TP53, HPV status) using immunohistochemistry and PCR. Clinical data were collected from medical records. Treatment response, survival, and associations with biomarkers were analyzed. \u0000Results: 250 patients were included. PD-L1 expression was associated with improved response to immunotherapy (p = 0.02). EGFR overexpression correlated with worse overall survival (p = 0.01). TP53 mutations were linked to increased locoregional recurrence (p = 0.03). HPV-positive tumors had a better prognosis (p < 0.001). \u0000Conclusion: Molecular biomarkers show promise in predicting treatment response and survival in HNSCC. Integration of these markers into clinical practice could facilitate personalized treatment strategies.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"77 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Age-related hearing loss (ARHL), commonly referred to as presbycusis, ranks as the third most prevalent health issue among older individuals, following heart disease and arthritis. This is a progressive, symmetrical, age-related sensorineural hearing impairment that primarily affects higher frequencies. This review was aimed to describe age related hearing loss and depression in elder people. Individuals who suffer from tinnitus and experience difficulty discerning speech in noisy environments are at a higher risk of developing paradoxical hypersensitivity to loud sounds. Consequently, individuals with age-related hearing loss (ARHL) experience increased challenges in perceiving consonant sounds inside words. These sounds play a crucial role in conveying the main message of a word, aiding in syllable separation, and indicating word boundaries. Healthcare providers must prioritize the screening and detection of HL (hearing loss) and depression. Initially, primary care providers may be most adept at identifying both hearing loss (HL) and depression.
{"title":"Age-related Hearing Loss and Its Correlation with Depression","authors":"Rohayu Rohayu","doi":"10.59345/sjorl.v1i2.80","DOIUrl":"https://doi.org/10.59345/sjorl.v1i2.80","url":null,"abstract":"Age-related hearing loss (ARHL), commonly referred to as presbycusis, ranks as the third most prevalent health issue among older individuals, following heart disease and arthritis. This is a progressive, symmetrical, age-related sensorineural hearing impairment that primarily affects higher frequencies. This review was aimed to describe age related hearing loss and depression in elder people. Individuals who suffer from tinnitus and experience difficulty discerning speech in noisy environments are at a higher risk of developing paradoxical hypersensitivity to loud sounds. Consequently, individuals with age-related hearing loss (ARHL) experience increased challenges in perceiving consonant sounds inside words. These sounds play a crucial role in conveying the main message of a word, aiding in syllable separation, and indicating word boundaries. Healthcare providers must prioritize the screening and detection of HL (hearing loss) and depression. Initially, primary care providers may be most adept at identifying both hearing loss (HL) and depression.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"89 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138945355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Chronic suppurative otitis media (CSOM) is marked by ear discharge (otorrhea) that lasts for more than six to eight weeks, middle ear inflammation that doesn't go away, and a ruptured eardrum. The purpose of this study is to describe examples of CSOM with facial nerve paresis and how such cases are managed. Case presentation: A thirty-year-old man complained to the Mataram Community Health Center two days before admission that his mouth was turning to the left, despite the fact that he was still able to speak well. Additionally, for four months, the patient complained of a constant discharge from the right ear. The fluid that emerges from the ear is sticky, yellow, and odorous; blood is not mixed with it. Upon inspection, a cholesteatoma and a flat-edge attic perforation on the tympanic membrane were discovered, together with a purulent and odorous discharge in the ear canal of the right ear. After a facial nerve examination, it was discovered that the forehead wrinkles were uneven and that the face was asymmetrical, with the right eyebrow unable to be raised. The patient was identified as having peripheral facial nerve paresis and persistent suppurative malignant otitis media of the auricula dextra. The patient is being treated with irrigation of the ear canal with 0.9% NaCl, cleaning of the cholesteatoma, and antibiotic administration: two drops of ofloxacin ear drops given twice a day, three times a day ciprofloxacin tablets 500 mg, three times a day methylprednisolone 16 mg, and advice to undergo a mastoidectomy. Conclusion: Complications including hearing loss, facial nerve palsy, subperiosteal abscess, petrositis, meningitis, cerebral abscess, and labyrinthine fistula are indicated for mastectomy surgical therapy.
{"title":"Chronic Suppurative Otitis Media Accompanied by Facial Nerve Paresis: A Case Report","authors":"Alia Oktarisa, Danisa Siregar","doi":"10.59345/sjorl.v1i2.79","DOIUrl":"https://doi.org/10.59345/sjorl.v1i2.79","url":null,"abstract":"Introduction: Chronic suppurative otitis media (CSOM) is marked by ear discharge (otorrhea) that lasts for more than six to eight weeks, middle ear inflammation that doesn't go away, and a ruptured eardrum. The purpose of this study is to describe examples of CSOM with facial nerve paresis and how such cases are managed. \u0000Case presentation: A thirty-year-old man complained to the Mataram Community Health Center two days before admission that his mouth was turning to the left, despite the fact that he was still able to speak well. Additionally, for four months, the patient complained of a constant discharge from the right ear. The fluid that emerges from the ear is sticky, yellow, and odorous; blood is not mixed with it. Upon inspection, a cholesteatoma and a flat-edge attic perforation on the tympanic membrane were discovered, together with a purulent and odorous discharge in the ear canal of the right ear. After a facial nerve examination, it was discovered that the forehead wrinkles were uneven and that the face was asymmetrical, with the right eyebrow unable to be raised. The patient was identified as having peripheral facial nerve paresis and persistent suppurative malignant otitis media of the auricula dextra. The patient is being treated with irrigation of the ear canal with 0.9% NaCl, cleaning of the cholesteatoma, and antibiotic administration: two drops of ofloxacin ear drops given twice a day, three times a day ciprofloxacin tablets 500 mg, three times a day methylprednisolone 16 mg, and advice to undergo a mastoidectomy. \u0000Conclusion: Complications including hearing loss, facial nerve palsy, subperiosteal abscess, petrositis, meningitis, cerebral abscess, and labyrinthine fistula are indicated for mastectomy surgical therapy.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The olfactory system is involved in detecting potential threats in the environment, generating sensations of enjoyment, facilitating proper nourishment, impacting sexual behavior, and regulating mood. Concurrently, the human taste system identifies hydrophilic molecules dissolved in saliva. The purpose of this review was to offer a thorough depiction of the human gustatory and olfactory systems. The various regions of the brain and the taste pathways transmit and receive information through distinct mechanisms. The taste circuits and various regions of the brain interconnect bidirectionally. The peripheral subdivision of the olfactory system consists of the olfactory epithelium and nerve fascicles. On the other hand, the central subdivision includes the olfactory bulb and its links to the central nervous system. Olfactory dysfunction (smell) and gustatory dysfunction (taste) can manifest independently or together. The robust correlation between olfaction and gustation engenders a gustatory feeling. Disruption of a feeling can alter the sense of flavor. Human olfactory and taste senses become less sensitive as they age.
{"title":"Overview of Anatomy and Physiology of Gustatory and Olfactory System","authors":"Tania Arifani","doi":"10.59345/sjorl.v1i2.93","DOIUrl":"https://doi.org/10.59345/sjorl.v1i2.93","url":null,"abstract":"The olfactory system is involved in detecting potential threats in the environment, generating sensations of enjoyment, facilitating proper nourishment, impacting sexual behavior, and regulating mood. Concurrently, the human taste system identifies hydrophilic molecules dissolved in saliva. The purpose of this review was to offer a thorough depiction of the human gustatory and olfactory systems. The various regions of the brain and the taste pathways transmit and receive information through distinct mechanisms. The taste circuits and various regions of the brain interconnect bidirectionally. The peripheral subdivision of the olfactory system consists of the olfactory epithelium and nerve fascicles. On the other hand, the central subdivision includes the olfactory bulb and its links to the central nervous system. Olfactory dysfunction (smell) and gustatory dysfunction (taste) can manifest independently or together. The robust correlation between olfaction and gustation engenders a gustatory feeling. Disruption of a feeling can alter the sense of flavor. Human olfactory and taste senses become less sensitive as they age.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"19 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138947562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stem cells play a crucial role in the advancement of restorative hearing therapy, marking the beginning of a new era in the treatment of hearing loss. Researchers are currently focusing on studying many types of stem cells, including mesenchymal stem cells (MSC), embryonic stem cells (ESC), induced pluripotent stem cells (iPSC), neural stem cells (NSC), and otic progenitor cells, in order to restore or enhance hearing function. Stem cells possess the capacity to undergo differentiation into auditory cells, namely hair cells within the cochlea, which serves as the foundation for the restoration of auditory functionality. Stem cells promote the regeneration of nearby tissue, facilitate the development of new auditory cells, and enhance the quality of the ear's mucous membrane, thus establishing a conducive environment for healing. It is the stem cells that make growth factors, which help repair, regeneration, and differentiation of new auditory cells. This creates an ideal environment for cells to multiply. By enabling the creation of customized therapies that can specifically match the unique characteristics of each patient, induced pluripotent stem cells (iPSC) introduce a personalized approach to treating hearing loss.
{"title":"The Role of Stem Cells in Hearing Restorative Therapy","authors":"Rachmat Hidayat","doi":"10.59345/sjorl.v1i2.94","DOIUrl":"https://doi.org/10.59345/sjorl.v1i2.94","url":null,"abstract":"Stem cells play a crucial role in the advancement of restorative hearing therapy, marking the beginning of a new era in the treatment of hearing loss. Researchers are currently focusing on studying many types of stem cells, including mesenchymal stem cells (MSC), embryonic stem cells (ESC), induced pluripotent stem cells (iPSC), neural stem cells (NSC), and otic progenitor cells, in order to restore or enhance hearing function. Stem cells possess the capacity to undergo differentiation into auditory cells, namely hair cells within the cochlea, which serves as the foundation for the restoration of auditory functionality. Stem cells promote the regeneration of nearby tissue, facilitate the development of new auditory cells, and enhance the quality of the ear's mucous membrane, thus establishing a conducive environment for healing. It is the stem cells that make growth factors, which help repair, regeneration, and differentiation of new auditory cells. This creates an ideal environment for cells to multiply. By enabling the creation of customized therapies that can specifically match the unique characteristics of each patient, induced pluripotent stem cells (iPSC) introduce a personalized approach to treating hearing loss.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"10 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138943896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The condition of allergic rhinitis involves a complex interaction between the immune system and certain allergens. The main process begins with sensitization, in which susceptible individuals develop an immune response to an allergen, often involving the production of IgE specific to that allergen. Mast cells and Th2 cells play a central role in the allergic response, with the release of inflammatory mediators such as histamine, interleukin-4 (IL-4), IL-5, and IL-13. Histamine, produced mainly by mast cells, causes typical symptoms of allergic rhinitis such as a runny nose, itching, sneezing, and nasal congestion. In addition, eosinophils, a specific type of white blood cell, gather in nasal tissues and contribute to chronic inflammation. Activation of eosinophils by cytokines such as IL-5 can cause tissue damage and prolong inflammation. This process creates a cycle of allergic responses that can be amplified with each subsequent exposure to the allergen. Sensitization, IgE production, release of inflammatory mediators, and tissue damage all together form the immunobiology basis of allergic rhinitis.
{"title":"Study of Immunobiological Aspects of Allergic Rhinitis","authors":"Rachmat Hidayat","doi":"10.59345/sjorl.v1i2.92","DOIUrl":"https://doi.org/10.59345/sjorl.v1i2.92","url":null,"abstract":"The condition of allergic rhinitis involves a complex interaction between the immune system and certain allergens. The main process begins with sensitization, in which susceptible individuals develop an immune response to an allergen, often involving the production of IgE specific to that allergen. Mast cells and Th2 cells play a central role in the allergic response, with the release of inflammatory mediators such as histamine, interleukin-4 (IL-4), IL-5, and IL-13. Histamine, produced mainly by mast cells, causes typical symptoms of allergic rhinitis such as a runny nose, itching, sneezing, and nasal congestion. In addition, eosinophils, a specific type of white blood cell, gather in nasal tissues and contribute to chronic inflammation. Activation of eosinophils by cytokines such as IL-5 can cause tissue damage and prolong inflammation. This process creates a cycle of allergic responses that can be amplified with each subsequent exposure to the allergen. Sensitization, IgE production, release of inflammatory mediators, and tissue damage all together form the immunobiology basis of allergic rhinitis.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"174 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139172527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This literature review aimed to describe the anatomical and histological aspects of the trachea, pharynx, larynx, and esophagus. The trachea is a tube-shaped respiratory tract consisting of cartilage and muscle and lined by a pseudostratified columnar ciliated epithelium. The pharynx is a funnel-shaped fibromuscular pouch that is large at the top and narrow at the bottom. This pouch starts at the base of the skull and continues through the esophagus to the level of the sixth cervical vertebra. The laryngopharynx is bordered superiorly by the upper edge of the epiglottis, anteriorly by the larynx, inferiorly by the esophagus, and posteriorly by the cervical vertebrae. The esophagus is a hollow cylindrical organ about 25 cm long and 2 cm in diameter, which extends from the hypopharynx to the cardia of the stomach. The esophagus lies posterior to the heart and trachea, anterior to the vertebrae, and pierces the diaphragmatic hiatus just anterior to the aorta. In conclusion, a thorough understanding of neck anatomy helps establish the diagnosis and management of patients in clinical situations.
{"title":"Overview Aspects of Anatomy and Histology of the Trachea, Pharynx, Larynx, and Esophagus: A Narrative Literature Review","authors":"Mariance, Yoan Levia Magdi","doi":"10.59345/sjorl.v1i1.35","DOIUrl":"https://doi.org/10.59345/sjorl.v1i1.35","url":null,"abstract":"This literature review aimed to describe the anatomical and histological aspects of the trachea, pharynx, larynx, and esophagus. The trachea is a tube-shaped respiratory tract consisting of cartilage and muscle and lined by a pseudostratified columnar ciliated epithelium. The pharynx is a funnel-shaped fibromuscular pouch that is large at the top and narrow at the bottom. This pouch starts at the base of the skull and continues through the esophagus to the level of the sixth cervical vertebra. The laryngopharynx is bordered superiorly by the upper edge of the epiglottis, anteriorly by the larynx, inferiorly by the esophagus, and posteriorly by the cervical vertebrae. The esophagus is a hollow cylindrical organ about 25 cm long and 2 cm in diameter, which extends from the hypopharynx to the cardia of the stomach. The esophagus lies posterior to the heart and trachea, anterior to the vertebrae, and pierces the diaphragmatic hiatus just anterior to the aorta. In conclusion, a thorough understanding of neck anatomy helps establish the diagnosis and management of patients in clinical situations.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133827896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Chronic suppurative otitis media (CSOM) is a chronic inflammation of the middle ear mucosa and mastoid space. Cholesteatoma is an ectopic keratinized epithelial tissue that develops through the mucosa of the middle ear cavity and desquamates, resulting in the accumulation of keratin and epithelial debris. This study aimed to determine the relationship between the stage of cholesteatoma and the degree of erosion of the ossicles in patients CSOM with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study was an observational case series study. A total of 70 research subjects were included in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients with a diagnosis of CSOM with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia and have complete medical record data. Data analysis was carried out using SPSS software version 25. Correlation analysis between cholesteatoma stage and degree of osseous erosion was performed using the Spearman correlation test, p<0.05. Results: The majority of research subjects were aged 21-30 years (28.6%) and were male (51.4%). Based on clinical symptoms, the majority of patients experience otorrhoea for 5 to 10 years (47.1%), perforated type membrane total tympani (54.3%), degree of erosion of the ossicles type D (48.6%), stage 4 cholesteatoma (61.4%) and granulation tissue (81.4%). Conclusion: There is a relationship between the stage of cholesteatoma and the degree of erosion of the ossicles in patients with CSOM (chronic suppurative otitis media) with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia.
慢性化脓性中耳炎(CSOM)是一种中耳粘膜和乳突间隙的慢性炎症。胆脂瘤是一种异位角化上皮组织，通过中耳腔粘膜发育并脱落，导致角蛋白和上皮碎片积聚。在印度尼西亚巴东的Dr. M. Djamil总医院，本研究旨在确定胆脂瘤合并CSOM患者的胆脂瘤阶段与听骨侵蚀程度之间的关系。方法:本研究为观察性病例系列研究。本研究共纳入70名研究对象，研究对象均符合纳入标准。本研究的入选标准是在印度尼西亚巴东Dr. M. Djamil总医院诊断为CSOM合并胆脂瘤的患者，并有完整的医疗记录资料。数据分析采用SPSS软件25版。采用Spearman相关检验分析胆脂瘤分期与骨侵蚀程度的相关性，p<0.05。结果:研究对象以21 ~ 30岁为主(28.6%)，男性占51.4%。从临床症状来看，大多数患者经历5 ~ 10年耳漏(47.1%)，穿孔型膜型全鼓室(54.3%)，听骨糜烂程度D型(48.6%)，4期胆脂瘤(61.4%)和肉芽组织(81.4%)。结论:在印度尼西亚巴东的Dr. M. Djamil总医院，慢性化脓性中耳炎合并胆脂瘤患者的胆脂瘤分期与听骨糜烂程度有关。
{"title":"The Relationship between Cholesteatoma Stage and Hearing Bone Erosion Degree in Chronic Suppurative Otitis Media Patients with Cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia","authors":"Bima Riantardo Hafni, Nirza Warto","doi":"10.59345/sjorl.v1i1.31","DOIUrl":"https://doi.org/10.59345/sjorl.v1i1.31","url":null,"abstract":"Introduction: Chronic suppurative otitis media (CSOM) is a chronic inflammation of the middle ear mucosa and mastoid space. Cholesteatoma is an ectopic keratinized epithelial tissue that develops through the mucosa of the middle ear cavity and desquamates, resulting in the accumulation of keratin and epithelial debris. This study aimed to determine the relationship between the stage of cholesteatoma and the degree of erosion of the ossicles in patients CSOM with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia. \u0000Methods: This study was an observational case series study. A total of 70 research subjects were included in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients with a diagnosis of CSOM with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia and have complete medical record data. Data analysis was carried out using SPSS software version 25. Correlation analysis between cholesteatoma stage and degree of osseous erosion was performed using the Spearman correlation test, p<0.05. \u0000Results: The majority of research subjects were aged 21-30 years (28.6%) and were male (51.4%). Based on clinical symptoms, the majority of patients experience otorrhoea for 5 to 10 years (47.1%), perforated type membrane total tympani (54.3%), degree of erosion of the ossicles type D (48.6%), stage 4 cholesteatoma (61.4%) and granulation tissue (81.4%). \u0000Conclusion: There is a relationship between the stage of cholesteatoma and the degree of erosion of the ossicles in patients with CSOM (chronic suppurative otitis media) with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123509369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Sensorineural deafness is deafness that occurs due to disturbances in the inner ear or in the nerve pathways from the inner ear to the brain. This study aimed to provide an overview of sensorineural deaf patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study was a descriptive observational study and used secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 50 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients aged > 18 years who were diagnosed with sensorineural hearing loss at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, for the January-December 2022 period and had complete medical record data. Results: The majority of research subjects have an age range of > 50 years. Subject the majority of studies have male gender. The majority of research subjects complained of deafness in both ears. The majority of research subjects have a profound hearing threshold. Conclusion: Characteristics of sensorineural deafness at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, generally occur at the age of > 50 years, male gender, occurs bilaterally, and has a very poor hearing threshold.
简介:感觉神经性耳聋是由于内耳或从内耳到大脑的神经通路受到干扰而发生的耳聋。本研究旨在提供在印度尼西亚巨港的Dr. Mohammad Hoesin总医院的感觉神经性耳聋患者的概况。方法:本研究是一项描述性观察性研究，使用的二手数据来自印度尼西亚巨港Dr. Mohammad Hoesin总医院医疗档案装置的病历数据。本研究共有50名研究对象参与，研究对象均符合纳入标准。本研究的纳入标准是年龄> 18岁，于2022年1月至12月期间在印度尼西亚巨港Dr. Mohammad Hoesin总医院诊断为感音神经性听力损失的患者，并具有完整的医疗记录数据。结果:大多数研究对象的年龄范围> 50岁。研究对象多数为男性。大多数研究对象都抱怨双耳耳聋。大多数研究对象都有较深的听力阈值。结论:印度尼西亚巨港市Dr. Mohammad Hoesin总医院感音神经性耳聋的特点，一般发生在年龄> 50岁，男性，双侧发生，听力阈值很低。
{"title":"Overview of Sensorineural Deafness Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia","authors":"Ahmad Hifni, Abla Ghanie, Lisa Apriyanti","doi":"10.59345/sjorl.v1i1.34","DOIUrl":"https://doi.org/10.59345/sjorl.v1i1.34","url":null,"abstract":"Introduction: Sensorineural deafness is deafness that occurs due to disturbances in the inner ear or in the nerve pathways from the inner ear to the brain. This study aimed to provide an overview of sensorineural deaf patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. \u0000Methods: This study was a descriptive observational study and used secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 50 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients aged > 18 years who were diagnosed with sensorineural hearing loss at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, for the January-December 2022 period and had complete medical record data. \u0000Results: The majority of research subjects have an age range of > 50 years. Subject the majority of studies have male gender. The majority of research subjects complained of deafness in both ears. The majority of research subjects have a profound hearing threshold. \u0000Conclusion: Characteristics of sensorineural deafness at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, generally occur at the age of > 50 years, male gender, occurs bilaterally, and has a very poor hearing threshold.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130681630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Pharyngitis presents with a variety of symptoms, including sudden sore throat, fever, headache, lymphadenitis, and sometimes abdominal pain, nausea, fatigue, and/or rash. This study aimed to provide data on the basic characteristics of acute pharyngitis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study was a descriptive observational study. This study uses secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 100 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients diagnosed with acute pharyngitis at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, for the period January – December 2022 and who have complete medical record data. Observations on sociodemographic data as well as observations on clinical data, were carried out in this study. Univariate data analysis was performed to present the distribution of frequencies and percentages of each variable. Data analysis was carried out using SPSS version 25. Results: The majority of research subjects are in the age range of 0-14 years. The majority of research subjects are female. The majority of research subjects had clinical symptoms of sore throat and difficulty swallowing. The symptoms that arise in acute pharyngitis depend on the microorganisms that accompany it. Acute pharyngitis caused by bacteria is characterized by severe headache, fever or chills, malaise, painful swallowing, vomiting, and possibly coughing but rarely. Conclusion: The characteristics of pharyngitis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, are aged 0-14 years with prominent clinical symptoms of sore throat and difficulty swallowing.
简介:咽炎表现为多种症状，包括突然喉咙痛、发烧、头痛、淋巴结炎，有时还会出现腹痛、恶心、疲劳和/或皮疹。本研究旨在提供关于印度尼西亚巨港市穆罕默德·胡森总医院急性咽炎患者基本特征的数据。方法:本研究为描述性观察性研究。本研究使用的二手数据来自印度尼西亚巨港Dr. Mohammad Hoesin总医院医疗档案装置的病历数据。本研究共有100名研究对象参与，研究对象均符合纳入标准。本研究的纳入标准是2022年1月至12月期间在印度尼西亚巨港的Dr. Mohammad Hoesin总医院诊断为急性咽炎的患者，并且具有完整的医疗记录数据。本研究对社会人口统计数据和临床数据进行了观察。进行单变量数据分析，以呈现每个变量的频率和百分比分布。数据分析采用SPSS 25版本。结果:研究对象以0 ~ 14岁为主。大多数研究对象是女性。大多数研究对象有喉咙痛和吞咽困难的临床症状。急性咽炎的症状取决于伴随咽炎的微生物。由细菌引起的急性咽炎的特点是严重头痛、发烧或发冷、不适、吞咽疼痛、呕吐，并可能咳嗽，但很少。结论:印度尼西亚巨港市Dr. Mohammad Hoesin总医院的咽炎患者年龄为0 ~ 14岁，临床表现以喉咙痛、吞咽困难为主。
{"title":"Characteristics of Acute Pharyngitis at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia","authors":"Puspa Zuleika, Adelien","doi":"10.59345/sjorl.v1i1.33","DOIUrl":"https://doi.org/10.59345/sjorl.v1i1.33","url":null,"abstract":"Introduction: Pharyngitis presents with a variety of symptoms, including sudden sore throat, fever, headache, lymphadenitis, and sometimes abdominal pain, nausea, fatigue, and/or rash. This study aimed to provide data on the basic characteristics of acute pharyngitis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. \u0000Methods: This study was a descriptive observational study. This study uses secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 100 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients diagnosed with acute pharyngitis at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, for the period January – December 2022 and who have complete medical record data. Observations on sociodemographic data as well as observations on clinical data, were carried out in this study. Univariate data analysis was performed to present the distribution of frequencies and percentages of each variable. Data analysis was carried out using SPSS version 25. \u0000Results: The majority of research subjects are in the age range of 0-14 years. The majority of research subjects are female. The majority of research subjects had clinical symptoms of sore throat and difficulty swallowing. The symptoms that arise in acute pharyngitis depend on the microorganisms that accompany it. Acute pharyngitis caused by bacteria is characterized by severe headache, fever or chills, malaise, painful swallowing, vomiting, and possibly coughing but rarely. \u0000Conclusion: The characteristics of pharyngitis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, are aged 0-14 years with prominent clinical symptoms of sore throat and difficulty swallowing.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124355502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：