Pub Date : 2021-06-30DOI: 10.52540/2074-9457.2021.2.12
V. Kuhach, E. S. Shabunin
The article is devoted to the study of factors influencing the number of calls for emergency teams (Emergency Teams - hereinafter ETs) to pharmacies in Minsk and regional centers of the Republic of Belarus. The data about the number of calls to ETs are provided by the city or regional emergency medical settings (hereinafter referred as EMS). A retrospective analysis of ETs calls to pharmacies was carried out during 01.01.2013-31.12.2018. The study covered 2,214 ETs calls and 1,386 pharmacies were included. The factors studied were considered: the number of population living in Minsk and regional centers, the form of pharmacies ownership, their category and location, the distance from health care institutions, the presence of traffiс bus stops (including underground railway stations) and shopping facilities near pharmacies. We used the correlation analysis and 2 x 2 contingency tables to study the relationship between the number of ETs calls to pharmacies. As a result of the study, it was found out that with an increase in the population and the number of pharmacies of the 1st, 2nd and 5th categories the number of calls to pharmacies increased; more calls were from pharmacies of the 1st and 2nd categories compared to pharmacies of the 5th category in Minsk and regional centers. There is a tendency to the decrease of ETs calls to pharmacies as to their distance from healthcare institutions. The other factors (pharmacy location, traffic bus stops and trade organizations locations near it) influence the number of ETs calls to pharmacies in different ways depending on the region. It is concluded that at any pharmacy a customer may have a health problem requiring medical care.
{"title":"ANALYSIS OF FACTORS INFLUENCING THE NUMBER OF CALLS FOR EMERGENCY TEAMS TO PHARMACIES OF THE REPUBLIC OF BELARUS","authors":"V. Kuhach, E. S. Shabunin","doi":"10.52540/2074-9457.2021.2.12","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.12","url":null,"abstract":"The article is devoted to the study of factors influencing the number of calls for emergency teams (Emergency Teams - hereinafter ETs) to pharmacies in Minsk and regional centers of the Republic of Belarus. The data about the number of calls to ETs are provided by the city or regional emergency medical settings (hereinafter referred as EMS). A retrospective analysis of ETs calls to pharmacies was carried out during 01.01.2013-31.12.2018. The study covered 2,214 ETs calls and 1,386 pharmacies were included. The factors studied were considered: the number of population living in Minsk and regional centers, the form of pharmacies ownership, their category and location, the distance from health care institutions, the presence of traffiс bus stops (including underground railway stations) and shopping facilities near pharmacies. We used the correlation analysis and 2 x 2 contingency tables to study the relationship between the number of ETs calls to pharmacies. As a result of the study, it was found out that with an increase in the population and the number of pharmacies of the 1st, 2nd and 5th categories the number of calls to pharmacies increased; more calls were from pharmacies of the 1st and 2nd categories compared to pharmacies of the 5th category in Minsk and regional centers. There is a tendency to the decrease of ETs calls to pharmacies as to their distance from healthcare institutions. The other factors (pharmacy location, traffic bus stops and trade organizations locations near it) influence the number of ETs calls to pharmacies in different ways depending on the region. It is concluded that at any pharmacy a customer may have a health problem requiring medical care.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73704638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.52540/2074-9457.2021.2.80
V. B. Klimashevich, E. V. Kokusev, V. V. Gudovich, O. A. Kazyuchits, A. Zhebentyaev
The article presents the results of the research on the development of the procedure for determining related impurities by high-performance reversed-phase chromatography in the tablets “Ranolazin-NAN”. The conditions for samples preparation of ranolazine tablets, optimal conditions for the gradient mode of chromatography were selected using Zorbax Eclipse Plus C18 column: eluent A - 0,1% triethylamine buffer with pH 6,0 ± 0,1 (diluted with orthophosphoric acid) and acetonitrile in a ratio 70:30 v / v and eluent B - acetonitrile. The effect of pH medium (2,0, 6,0 and 9,0) on the efficiency of the column while studying the solutions of ranolazine and identified impurities was established. The suitability of the chromatographic system was proven and the specificity of the method for determining unidentified and identified impurities was proven. Linearity in the entire range of the procedure usage (from the quantitation limit to 125% (of the content of a single impurity)), correctness as well as precision at the level of reproductivity and intermediate precision, and the stability (robustness) of the method with small changes in the flow rate and column temperature were proven for the procedure of related impurities determination in Ranolazin-NAN tablets.
本文介绍了高效反相色谱法测定Ranolazin-NAN片剂中相关杂质的研究结果。采用Zorbax Eclipse Plus C18色谱柱，确定了样品制备条件和梯度层析的最佳条件:洗脱液A - 0.1%三乙胺缓冲液(pH值为6,0±0,1)(用正磷酸稀释)与乙腈的比例为70:30 v / v，洗脱液B -乙腈。建立了pH(2、0、6、0和9、0)对色谱柱效率的影响，同时研究了雷诺嗪溶液和鉴定的杂质。证明了色谱系统的适用性，证明了该方法测定未鉴别和已鉴别杂质的特异性。结果表明，该方法在整个方法使用范围内(从定量限到125%(单一杂质含量))具有良好的线性关系，在重现性和中间精密度水平上具有良好的准确性和精密度，在流速和柱温变化很小的情况下具有良好的稳定性(鲁棒性)。
{"title":"DEVELOPMENT AND VALIDATION OF THE PROCEDURE FOR QUANTITATIVE DETERMINATION OF IMPURITIES IN TABLETS “RANOLAZIN-NAN”","authors":"V. B. Klimashevich, E. V. Kokusev, V. V. Gudovich, O. A. Kazyuchits, A. Zhebentyaev","doi":"10.52540/2074-9457.2021.2.80","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.80","url":null,"abstract":"The article presents the results of the research on the development of the procedure for determining related impurities by high-performance reversed-phase chromatography in the tablets “Ranolazin-NAN”. The conditions for samples preparation of ranolazine tablets, optimal conditions for the gradient mode of chromatography were selected using Zorbax Eclipse Plus C18 column: eluent A - 0,1% triethylamine buffer with pH 6,0 ± 0,1 (diluted with orthophosphoric acid) and acetonitrile in a ratio 70:30 v / v and eluent B - acetonitrile. The effect of pH medium (2,0, 6,0 and 9,0) on the efficiency of the column while studying the solutions of ranolazine and identified impurities was established. The suitability of the chromatographic system was proven and the specificity of the method for determining unidentified and identified impurities was proven. Linearity in the entire range of the procedure usage (from the quantitation limit to 125% (of the content of a single impurity)), correctness as well as precision at the level of reproductivity and intermediate precision, and the stability (robustness) of the method with small changes in the flow rate and column temperature were proven for the procedure of related impurities determination in Ranolazin-NAN tablets.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89476848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.52540/2074-9457.2021.2.59
O. M. Khishova, V. D. Avdachenok
The paper presents studying sedative activity of the combined tincture of motherwort and St. John's wort. The combined tincture of motherwort and St. John's wort was obtained by percolation method in a ratio 1:10. Standardization of the obtained tincture was carried out with quality indicators: description, content of active ingredients and ethanol, relative density, dry residue. According to all quality indicators, the tincture obtained met the requirements of the State Pharmacopoeia of the Republic of Belarus. Specific sedative activity of the combined tincture of motherwort and St. John's wort was assessed by barbiturates hypnotic effect prolongation (sodium thiopental), by the rate of falling asleep in animals and by animals staying in lateral position in relation to the control group to which sodium thiopental was injected. In the studies carried out it was found that injection of the combined tincture of motherwort and St. John's wort at a dose of 0,1 ml / kg increases sleep by 125,63% and also accelerates the process of falling asleep by 327,75% compared with the separate injection of motherwort and St. John's wort tincture at doses of 0,1 ml/kg. It was shown that the injection of the combined tincture of motherwort and St. John's wort at a dose of 0,1 ml/kg exhibits a potentiated effect and enhances the hypnotic effect of sodium thiopental administered at a dose of 10 mg/kg.
{"title":"STUDYING SEDATIVE ACTIVITY OF COMBINED TINCTURE OF MOTHERWORT AND ST JOHN'S-WORT","authors":"O. M. Khishova, V. D. Avdachenok","doi":"10.52540/2074-9457.2021.2.59","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.59","url":null,"abstract":"The paper presents studying sedative activity of the combined tincture of motherwort and St. John's wort. The combined tincture of motherwort and St. John's wort was obtained by percolation method in a ratio 1:10. Standardization of the obtained tincture was carried out with quality indicators: description, content of active ingredients and ethanol, relative density, dry residue. According to all quality indicators, the tincture obtained met the requirements of the State Pharmacopoeia of the Republic of Belarus. Specific sedative activity of the combined tincture of motherwort and St. John's wort was assessed by barbiturates hypnotic effect prolongation (sodium thiopental), by the rate of falling asleep in animals and by animals staying in lateral position in relation to the control group to which sodium thiopental was injected. In the studies carried out it was found that injection of the combined tincture of motherwort and St. John's wort at a dose of 0,1 ml / kg increases sleep by 125,63% and also accelerates the process of falling asleep by 327,75% compared with the separate injection of motherwort and St. John's wort tincture at doses of 0,1 ml/kg. It was shown that the injection of the combined tincture of motherwort and St. John's wort at a dose of 0,1 ml/kg exhibits a potentiated effect and enhances the hypnotic effect of sodium thiopental administered at a dose of 10 mg/kg.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86270694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.52540/2074-9457.2021.2.33
S. E. Rzheussky, P. S. Varabei
The article studies the domestic market of vasodilators for cardiac diseases in Belarus by analyzing and comparing secondary marketing information. The structure of the market depending on the manufacturing country was studied. It was established that medicines containing isosorbide mononitrate/dinitrate have the greatest number of indications to use and the least number of side effects. The dynamics of changing the sales of medicines in the vasodilators group for cardiac diseases for the period 2010-2018 is presented. The market attractiveness of medicines of the vasodilators group for cardiac diseases was studied using the matrix of the Boston Consulting Group (BCG matrix).
{"title":"VASODILATORS FOR THE TREATMENT OF CARDIAC DISEASES (С01D) ON THE PHARMACEUTICAL MARKET OF THE REPUBLIC OF BELARUS","authors":"S. E. Rzheussky, P. S. Varabei","doi":"10.52540/2074-9457.2021.2.33","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.33","url":null,"abstract":"The article studies the domestic market of vasodilators for cardiac diseases in Belarus by analyzing and comparing secondary marketing information. The structure of the market depending on the manufacturing country was studied. It was established that medicines containing isosorbide mononitrate/dinitrate have the greatest number of indications to use and the least number of side effects. The dynamics of changing the sales of medicines in the vasodilators group for cardiac diseases for the period 2010-2018 is presented. The market attractiveness of medicines of the vasodilators group for cardiac diseases was studied using the matrix of the Boston Consulting Group (BCG matrix).","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87357705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.52540/2074-9457.2021.2.101
A. L. Tserkovskiy, O. I. Gapova, E. A. Skorikova, S. A. Petrovich, O. A. Kasyan, V. Muzhichenko
The purpose of this research is to study the need for the students' communication activity component at the Pharmaceutical faculty of VSMU. Dual feature of the levels indicators dynamics in the need for communication is revealed. On the one hand, there is a tendency to reduce the average level in the need for communication and to increase its high level at the expense of girls. On the other hand, there is a fairly significant increase in the average level in the need for communication among young men against the background of an obvious predominance of the average level in the need for communication among the students of the entire sampling. The study allows us to state obvious influence of the informational educational environment at VSMU on the personal growth of students at the Pharmaceutical faculty, on the formation of their communicative competence as the most important component of the professional competence of future pharmacists. The results of the study can be used in the educational process of VSMU, in the activities of the social and pedagogical and psychological service, in the work of educators in academic groups and for tutors.
{"title":"TO THE DYNAMICS OF THE NEED FOR STUDENTS' COMMUNICATION ACTIVITY COMPONENT AT THE PHARMACEUTICAL FACULTY OF VSMU","authors":"A. L. Tserkovskiy, O. I. Gapova, E. A. Skorikova, S. A. Petrovich, O. A. Kasyan, V. Muzhichenko","doi":"10.52540/2074-9457.2021.2.101","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.101","url":null,"abstract":"The purpose of this research is to study the need for the students' communication activity component at the Pharmaceutical faculty of VSMU. Dual feature of the levels indicators dynamics in the need for communication is revealed. On the one hand, there is a tendency to reduce the average level in the need for communication and to increase its high level at the expense of girls. On the other hand, there is a fairly significant increase in the average level in the need for communication among young men against the background of an obvious predominance of the average level in the need for communication among the students of the entire sampling. The study allows us to state obvious influence of the informational educational environment at VSMU on the personal growth of students at the Pharmaceutical faculty, on the formation of their communicative competence as the most important component of the professional competence of future pharmacists. The results of the study can be used in the educational process of VSMU, in the activities of the social and pedagogical and psychological service, in the work of educators in academic groups and for tutors.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"147 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87127830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.52540/2074-9457.2021.2.93
O. G. Sechko, N. Gurina, V. M. Tsarenkov, I. Slabko, F. Macaev, A. Uncu, V. Valica
The compounds studied are propylthiadiazoloquinazoline derivatives, tryptanthrin analogs. Tryptantrin and its derivatives were found to have different antimycobacterial activity in vitro and in vivo. This series of experiments is devoted to the study of antimycobacterial activity of three propylthiadiazoloquinazoline derivatives obtained in the laboratory of organic synthesis and Biopharmaceutics of the Institute of Chemistry of the Academy of Sciences in Moldova using a non-tuberculous strain of Mycobacterium intracellulare, which is a part of the Mycobacterium avium complex (MAC). Species of the MAC are one of the main pathogen types causing mycobacteriosis. In this regard, propylthiadiazoloquinazoline derivatives are of interest for a comprehensive study as a potential antimycobacterial drug. To study antimycobacterial activity the method of dilutions in a dense nutrient medium of Middlebrook 7H9 broth with glycerol in Petri dishes was used. To assess antimycobacterial activity visual assessment of M. intracellulare growth in a solid nutrient medium was used. It is shown that the compounds studied inhibit M. Intracellulare growth. The most active compound was compound № 1 - 2-mercapto-5H-[1,3,4]-thiadiazolo-[2,3-b]-quinazoline-5-one.
{"title":"ASSESSMENT OF ANTIMYCOBACTERIAL ACTIVITY OF PROPYLTHIADIAZOLOQUINAZOLINE DERIVATIVES AGAINST MYCOBACTERIUM INTRACELLULARE","authors":"O. G. Sechko, N. Gurina, V. M. Tsarenkov, I. Slabko, F. Macaev, A. Uncu, V. Valica","doi":"10.52540/2074-9457.2021.2.93","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.93","url":null,"abstract":"The compounds studied are propylthiadiazoloquinazoline derivatives, tryptanthrin analogs. Tryptantrin and its derivatives were found to have different antimycobacterial activity in vitro and in vivo. This series of experiments is devoted to the study of antimycobacterial activity of three propylthiadiazoloquinazoline derivatives obtained in the laboratory of organic synthesis and Biopharmaceutics of the Institute of Chemistry of the Academy of Sciences in Moldova using a non-tuberculous strain of Mycobacterium intracellulare, which is a part of the Mycobacterium avium complex (MAC). Species of the MAC are one of the main pathogen types causing mycobacteriosis. In this regard, propylthiadiazoloquinazoline derivatives are of interest for a comprehensive study as a potential antimycobacterial drug. To study antimycobacterial activity the method of dilutions in a dense nutrient medium of Middlebrook 7H9 broth with glycerol in Petri dishes was used. To assess antimycobacterial activity visual assessment of M. intracellulare growth in a solid nutrient medium was used. It is shown that the compounds studied inhibit M. Intracellulare growth. The most active compound was compound № 1 - 2-mercapto-5H-[1,3,4]-thiadiazolo-[2,3-b]-quinazoline-5-one.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83039574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.52540/2074-9457.2021.2.48
G. Buzuk
Despite intensive development of instrumental methods of environmental factors analysis for plant communities their assessment with ecological scales still remains important. The main advantage of ecological scales is their ability to reflect generalized and average characteristics of ecological regimes due to significant inertia in response of plant communities composition to the change of certain characteristics of the environment. The main ways of calculation while using ecological scales are the medium-sized method and the ideal indicator method (of linear regression) including modified algorithm of calculating the level of edaphic and climatic factors of the environment with amplitude ecological scales. The aim of this work was to improve further the method for assessing the level of ecological factors (ecological space) in plant communities. For calculations and visualization of the results obtained we used Excel and our own programs written in the Matlab media. The basis of the method is finding the factor averagely weighed for the level calculated by the traditional way and by the method of the ideal indicator. It is proposed to set the weight of factors in both methods of calculation both explicitly and depending on the ecological index reflecting correspondence (adequacy) of the plant community composition to the level of ecological factors prevailing in the habitat. They can also be calculated by linear or non-linear dependencies relative to the middle of amplitude ecological scale. The conclusion is that it is possible to predict the content of secondary metabolites in plants based on assessing the level of ecological factors for plant communities.
{"title":"COMPREHENSIVE WAY OF CALCULATING ECOLOGICAL (ENVIRONMENTAL SPACE) FACTORS OF PLANT COMMUNITIES ENVIRONMENT FOR AMPLITUDE ECOLOGICAL SCALES","authors":"G. Buzuk","doi":"10.52540/2074-9457.2021.2.48","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.48","url":null,"abstract":"Despite intensive development of instrumental methods of environmental factors analysis for plant communities their assessment with ecological scales still remains important. The main advantage of ecological scales is their ability to reflect generalized and average characteristics of ecological regimes due to significant inertia in response of plant communities composition to the change of certain characteristics of the environment. The main ways of calculation while using ecological scales are the medium-sized method and the ideal indicator method (of linear regression) including modified algorithm of calculating the level of edaphic and climatic factors of the environment with amplitude ecological scales. The aim of this work was to improve further the method for assessing the level of ecological factors (ecological space) in plant communities. For calculations and visualization of the results obtained we used Excel and our own programs written in the Matlab media. The basis of the method is finding the factor averagely weighed for the level calculated by the traditional way and by the method of the ideal indicator. It is proposed to set the weight of factors in both methods of calculation both explicitly and depending on the ecological index reflecting correspondence (adequacy) of the plant community composition to the level of ecological factors prevailing in the habitat. They can also be calculated by linear or non-linear dependencies relative to the middle of amplitude ecological scale. The conclusion is that it is possible to predict the content of secondary metabolites in plants based on assessing the level of ecological factors for plant communities.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78756026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.52540/2074-9457.2021.2.24
S. G. Troina, V. Kuhach
The article presents the results of a sociological study conducted with the questionnaire of 385 pharmacy customers from different regions of the Republic of Belarus aged over 60 using Kano model. The respondents consistently expressed their attitude to the presence and absence of 13 characteristics (parameters) effecting the performance of pharmacies. The purpose of this study is to assess the loyalty of elderly customers to the pharmacy using Kano model. The potentials of elderly customers’ satisfaction and dissatisfaction with the work of pharmacies are calculated. The same parameter was revealed to have a different effect on the potential of satisfaction and dissatisfaction of pharmacy elderly customers. The distribution of the parameters studied into 4 quadrants allowed to determine mandatory characteristics of the pharmacy (availability of a wide range of products, competence of pharmaceutical workers; provision of the customers with detailed information about the purchased product), linear (location of the pharmacy, convenient schedule of its work, rational pricing policy, discount availability, informative and esthetic design of shop windows, benevolence of pharmaceutical workers) and indifferent ones (availability of car parking near the pharmacy, advertising items in the pharmacy, ability to get additional services in the pharmacy, modern technologies for population service). Attractive parameters were not set. The design of shop windows is at the border edge of mandatory and one-dimensional characteristics intersection. To attract customers and increase their loyalty to the pharmacy it is necessary to ensure availability of mandatory and to develop the category of linear characteristics.
{"title":"LOYALTY ASSESSMENT OF ELDERLY CUSTOMERS TO THE PHARMACY USING KANO MODEL","authors":"S. G. Troina, V. Kuhach","doi":"10.52540/2074-9457.2021.2.24","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.24","url":null,"abstract":"The article presents the results of a sociological study conducted with the questionnaire of 385 pharmacy customers from different regions of the Republic of Belarus aged over 60 using Kano model. The respondents consistently expressed their attitude to the presence and absence of 13 characteristics (parameters) effecting the performance of pharmacies. The purpose of this study is to assess the loyalty of elderly customers to the pharmacy using Kano model. The potentials of elderly customers’ satisfaction and dissatisfaction with the work of pharmacies are calculated. The same parameter was revealed to have a different effect on the potential of satisfaction and dissatisfaction of pharmacy elderly customers. The distribution of the parameters studied into 4 quadrants allowed to determine mandatory characteristics of the pharmacy (availability of a wide range of products, competence of pharmaceutical workers; provision of the customers with detailed information about the purchased product), linear (location of the pharmacy, convenient schedule of its work, rational pricing policy, discount availability, informative and esthetic design of shop windows, benevolence of pharmaceutical workers) and indifferent ones (availability of car parking near the pharmacy, advertising items in the pharmacy, ability to get additional services in the pharmacy, modern technologies for population service). Attractive parameters were not set. The design of shop windows is at the border edge of mandatory and one-dimensional characteristics intersection. To attract customers and increase their loyalty to the pharmacy it is necessary to ensure availability of mandatory and to develop the category of linear characteristics.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83673783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.52540/2074-9457.2021.1.36
E. Kerimli, S. V. Serkerov
The component composition of nobleyarrow L. essential oil growing in Azerbaijan was studied for the first time by gas chromatography-mass spectrometry method. 35 components, mainly terpenoid compounds, are identified in the essential oil of which the main ones are 15 components: artemisia ketone (23,7%), α-thujone (22,4%), 2-bornanone (6,4%), eudesma-7(11)-en-4-ol (6,3%), eucalyptol (4,5%), cubenol (3,3%), lavandulol (3,0%), β-thujone (2,9%), β-eudesmol (2,7%), methyl hinokiate (2,1%), terpinene-4-ol (1,7%), 1,2-longidione (1,3%), limonen-6-ol, pivalate (1,2%), neryl (S)-2-methylbutanoate (1,1%), сaryophyllene oxide (1,0%). As a result of noble yarrow essential oil research it was determined that, essential oil has high antimicrobial activity relative to Staphylacoccus aureus.
{"title":"STUDY OF COMPONENT COMPOSITION AND ANTIMICROBIAL ACTIVITY OF ACHILLEA NOBILIS L. ESSENTIAL OIL","authors":"E. Kerimli, S. V. Serkerov","doi":"10.52540/2074-9457.2021.1.36","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.1.36","url":null,"abstract":"The component composition of nobleyarrow L. essential oil growing in Azerbaijan was studied for the first time by gas chromatography-mass spectrometry method. 35 components, mainly terpenoid compounds, are identified in the essential oil of which the main ones are 15 components: artemisia ketone (23,7%), α-thujone (22,4%), 2-bornanone (6,4%), eudesma-7(11)-en-4-ol (6,3%), eucalyptol (4,5%), cubenol (3,3%), lavandulol (3,0%), β-thujone (2,9%), β-eudesmol (2,7%), methyl hinokiate (2,1%), terpinene-4-ol (1,7%), 1,2-longidione (1,3%), limonen-6-ol, pivalate (1,2%), neryl (S)-2-methylbutanoate (1,1%), сaryophyllene oxide (1,0%). As a result of noble yarrow essential oil research it was determined that, essential oil has high antimicrobial activity relative to Staphylacoccus aureus.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76870746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.52540/2074-9457.2021.1.86
S. S. Malchenkova, N. S. Golyak, V. M. Tsarenkov
The article presents the main types of laboratory animals that are used to study the transdermal permeability of chemical compounds. We described the structural features of epidermis, derma and skin appendages in humans and laboratory animals (small rodents, pigs, monkeys). We also emphasized advantages and disadvantages of various laboratory animals as objects for in vivo transdermal modeling. A method of extrapolation called “The parallelogram method” or «Triple Pack» has been singled out to predict the permeability of the human skin in the presence of experimental data on the permeability of the skin of animals in vivo and humans in vitro. The article describes the experimental design (including preparation of animals, premises and the substance applied) to determine transdermal permeability of substances in vivo under the guidelines of the World Health Organization and the Organization for Economic Cooperation and Development. Tissue microdialysis in volunteers has been identified as the most perfect and safest ways to promptly detect substances in the derma and tape stripping has been made in the cells of the stratum corneum.
{"title":"THE ROLE OF IN VIVO MODELS IN PREDICTING TRANSDERMAL PERMEABILITY","authors":"S. S. Malchenkova, N. S. Golyak, V. M. Tsarenkov","doi":"10.52540/2074-9457.2021.1.86","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.1.86","url":null,"abstract":"The article presents the main types of laboratory animals that are used to study the transdermal permeability of chemical compounds. We described the structural features of epidermis, derma and skin appendages in humans and laboratory animals (small rodents, pigs, monkeys). We also emphasized advantages and disadvantages of various laboratory animals as objects for in vivo transdermal modeling. A method of extrapolation called “The parallelogram method” or «Triple Pack» has been singled out to predict the permeability of the human skin in the presence of experimental data on the permeability of the skin of animals in vivo and humans in vitro. The article describes the experimental design (including preparation of animals, premises and the substance applied) to determine transdermal permeability of substances in vivo under the guidelines of the World Health Organization and the Organization for Economic Cooperation and Development. Tissue microdialysis in volunteers has been identified as the most perfect and safest ways to promptly detect substances in the derma and tape stripping has been made in the cells of the stratum corneum.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90703280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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