Background: The root of Tripterygium wilfordii (Tripterygii radix), a natural powerful traditional Chinese medicine (TCM) for various diseases treatment, has been used for centuries in the Asian countries as anti-rheumatoid arthritis (RA) agent, antioxidant agent, and anti-inflammatory agent. Its combination with other herbs in treating RA has been explored. The anti-RA effect of T. wilfordii for cancer treatment has been supported by some evidence. Aims and Objectives: To investigate the anticancer mechanism of T. wilfordii, bioinformatics databases were used to identify its active ingredients. Materials and Methods: Target proteins associated with cancer were determined using a network pharmacology analysis platform, and 25 key active compounds and 55 key targets of T. wilfordii were identified in our study. A common potential mechanism of T. wilfordii involvement in cancer was disclosed by in-depth network analysis of diseases, functions, and pathways. Finally, the analysis results of the TCM-disease target protein interaction network revealed 5 potential targets; subsequently, a total of 30 targets (these 5 targets, as well as 25 previously identified compounds) were subjected to molecular docking. Results: Our results showed that the therapeutic effect of T. wilfordii in cancer is characterized by multiple components, targets, and pathways. The regulation of signaling pathways such as Kaposi sarcoma-associated herpes virus infection, colorectal cancer, small-cell lung cancer, and prostate cancer may be the important pharmacodynamic basis of anticancer therapy. Conclusion: Triptonoditerpenic acid inhibited proliferation and induced apoptosis in SW480 cells. The mechanism may be related to the downregulation of Bcl-2 expression, upregulation of Bax mRNA expression, and expression inhibition of PTGS2.
{"title":"Exploring the mechanism of Tripterygium wilfordii against cancer using network pharmacology and molecular docking","authors":"Shuixiu Xiao, Shao Li, Wan-Xian Fang, Jv Chen, Hai-jian Li, Yongli Situ","doi":"10.4103/2311-8571.344544","DOIUrl":"https://doi.org/10.4103/2311-8571.344544","url":null,"abstract":"Background: The root of Tripterygium wilfordii (Tripterygii radix), a natural powerful traditional Chinese medicine (TCM) for various diseases treatment, has been used for centuries in the Asian countries as anti-rheumatoid arthritis (RA) agent, antioxidant agent, and anti-inflammatory agent. Its combination with other herbs in treating RA has been explored. The anti-RA effect of T. wilfordii for cancer treatment has been supported by some evidence. Aims and Objectives: To investigate the anticancer mechanism of T. wilfordii, bioinformatics databases were used to identify its active ingredients. Materials and Methods: Target proteins associated with cancer were determined using a network pharmacology analysis platform, and 25 key active compounds and 55 key targets of T. wilfordii were identified in our study. A common potential mechanism of T. wilfordii involvement in cancer was disclosed by in-depth network analysis of diseases, functions, and pathways. Finally, the analysis results of the TCM-disease target protein interaction network revealed 5 potential targets; subsequently, a total of 30 targets (these 5 targets, as well as 25 previously identified compounds) were subjected to molecular docking. Results: Our results showed that the therapeutic effect of T. wilfordii in cancer is characterized by multiple components, targets, and pathways. The regulation of signaling pathways such as Kaposi sarcoma-associated herpes virus infection, colorectal cancer, small-cell lung cancer, and prostate cancer may be the important pharmacodynamic basis of anticancer therapy. Conclusion: Triptonoditerpenic acid inhibited proliferation and induced apoptosis in SW480 cells. The mechanism may be related to the downregulation of Bcl-2 expression, upregulation of Bax mRNA expression, and expression inhibition of PTGS2.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47919297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/wjtcm.wjtcm_71_21
Qing Zhao, Shuyi Song, Meng-Qi Zhang, Xin Li, Yang Liu, Chang-Yun Wang
Objective: Haliotidis, the dried muscle of abalone, has long been used as a marine traditional Chinese medicine (TCM) due to its high medicinal and nutritive values, whereas few reports contributed to its quality control. This study aimed to establish the high-performance liquid chromatography (HPLC) fingerprints of Haliotidis. Materials and Methods: The HPLC fingerprints of Haliotidis, the manufacturing products of dried muscle of abalone, were analyzed by reverse-phase HPLC, using a YMC HPLC C18 column (250 mm × 4.6 mm, 5 μm). The gradient elution mode was applied with mobile phase starting from 5% acetonitrile and 0.1% phosphoric acid aqueous solution to 100% acetonitrile in 70 min at a flow rate of 1.0 mL/min. The detection wavelength was set at 190 nm. Results: Through compared the HPLC fingerprint chromatograms of 14 batches of Haliotidis, 25 peaks were assigned as the characteristic common peaks, of which one index component L-phenylalanine was identified by comparison with its standard substance. The established HPLC fingerprint analysis method of Haliotidis was validated with good precision, repeatability, and stability. Based on the above study, a reference HPLC fingerprint chromatogram of Haliotidis was proposed. Conclusions: It is the first time to establish the HPLC fingerprint chromatogram of TCM Haliotidis, which could contribute to the establishment of its quality control system.
目的:鲍鱼干肌因其具有较高的药用价值和营养价值，长期以来一直被用作海洋中药，但对其质量控制的报道较少。本研究的目的是建立苍尾草的高效液相色谱指纹图谱。材料与方法:采用反相高效液相色谱法，采用YMC高效液相色谱C18柱(250 mm × 4.6 mm, 5 μm)，对鲍鱼干肌的生产产品halotidis进行指纹图谱分析。采用梯度洗脱方式，流动相为5%乙腈和0.1%磷酸水溶液，流速为1.0 mL/min, 70 min。检测波长为190 nm。结果:通过对14批苍耳草HPLC指纹图谱的比对，确定了25个峰为特征共有峰，其中1个指标成分l -苯丙氨酸通过与其标准品的比对鉴定出。该方法精密度高，重复性好，稳定性好。在此基础上，建立了苍尾草的参考HPLC指纹图谱。结论:首次建立了中药苍耳草的HPLC指纹图谱，为其质量控制体系的建立提供了依据。
{"title":"High-performance liquid chromatography fingerprint of marine traditional Chinese medicine haliotidis","authors":"Qing Zhao, Shuyi Song, Meng-Qi Zhang, Xin Li, Yang Liu, Chang-Yun Wang","doi":"10.4103/wjtcm.wjtcm_71_21","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_71_21","url":null,"abstract":"Objective: Haliotidis, the dried muscle of abalone, has long been used as a marine traditional Chinese medicine (TCM) due to its high medicinal and nutritive values, whereas few reports contributed to its quality control. This study aimed to establish the high-performance liquid chromatography (HPLC) fingerprints of Haliotidis. Materials and Methods: The HPLC fingerprints of Haliotidis, the manufacturing products of dried muscle of abalone, were analyzed by reverse-phase HPLC, using a YMC HPLC C18 column (250 mm × 4.6 mm, 5 μm). The gradient elution mode was applied with mobile phase starting from 5% acetonitrile and 0.1% phosphoric acid aqueous solution to 100% acetonitrile in 70 min at a flow rate of 1.0 mL/min. The detection wavelength was set at 190 nm. Results: Through compared the HPLC fingerprint chromatograms of 14 batches of Haliotidis, 25 peaks were assigned as the characteristic common peaks, of which one index component L-phenylalanine was identified by comparison with its standard substance. The established HPLC fingerprint analysis method of Haliotidis was validated with good precision, repeatability, and stability. Based on the above study, a reference HPLC fingerprint chromatogram of Haliotidis was proposed. Conclusions: It is the first time to establish the HPLC fingerprint chromatogram of TCM Haliotidis, which could contribute to the establishment of its quality control system.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44403099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/wjtcm.wjtcm_69_21
P. Gupta, Kishor Sonewane, ShardaSwaroop Chouhan, M. Rajan, Nagendra Singh Chauhan, O. Rout, Awanish Kumar, G. Baghel
Moringa oleifera Lam. (Shigru) (Moringaceae family) is a traditional medicine used for control of diabetes, obesity, asthma, and cardiac, liver, gastrointestinal, infective, and brain disorders, such as depression and Alzheimer's disease. In Ayurvedic literature, Shigru is among few drugs having Balya (nourishing) as well as Medohara (antiobesity) property. This review focuses on valid connections between the properties documented in ancient literature and current pharmacological knowledge of Moringa, including pharmacological actions, phytochemistry, botanical description, and how Moringa can tackle malnutrition in India, especially Chhattisgarh. All information about M. oleifera was obtained from electronic scientific databases such as PubMed, Web of Science, Scopus, ScienceDirect, Elsevier, Google Scholar, Traditional Knowledge Digital Library, and Indian Traditional Books (Ancient Ayurveda literatures, The Wealth of India, and The Ayurvedic Formulary of India), postgraduate/doctoral thesis, and googling the keyword M. oleifera. M. oleifera have anti-oxidant, antimicrobial, anti-diabetic, anti-obesity, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, gastroprotective, wound-healing properties and it can potentially tackle malnutrition. This review describes the key information related to botanical description of M. oleifera, phytochemistry, pharmacological actions, clinical studies, toxicological studies, better utilization as food therapeutics, and ethnobotanical and evidence-based comparative review of M. oleifera. M. oleifera can effectively tackle malnutrition in India, especially Chhattisgarh. The authors emphasize the need for future in-depth ethnopharmacological lead-based research and clinical studies to expand M. oleifera pharmacological activities, clinical efficacy, and safety.
辣木。(辣木科)是一种传统药物，用于控制糖尿病，肥胖，哮喘，心脏，肝脏，胃肠道，感染和大脑疾病，如抑郁症和阿尔茨海默病。在阿育吠陀文献中，Shigru是少数具有Balya(滋养)和Medohara(抗肥胖)特性的药物之一。这篇综述的重点是古代文献中记录的辣木的特性与当前的药理知识之间的有效联系，包括药理作用，植物化学，植物描述，以及辣木如何解决印度，特别是恰蒂斯加尔邦的营养不良问题。所有关于M. oleifera的信息均来自PubMed、Web of Science、Scopus、ScienceDirect、Elsevier、b谷歌Scholar、传统知识数字图书馆和印度传统图书(古代阿育吠陀文献、印度财富和印度阿育吠陀处方集)等电子科学数据库，研究生/博士论文，并在谷歌上搜索关键词M. oleifera。油葵具有抗氧化、抗菌、抗糖尿病、抗肥胖、抗炎、保护心脏、保护肝脏、保护神经、保护胃、伤口愈合的特性，并有可能解决营养不良问题。本文综述了油桐的植物学描述、植物化学、药理作用、临床研究、毒理学研究、食品治疗利用以及油桐的民族植物学和循证比较研究等方面的重要信息。M. oleifera可以有效解决印度，特别是恰蒂斯加尔邦的营养不良问题。作者强调未来需要深入开展基于铅的民族药理学研究和临床研究，以扩大油桐的药理活性、临床疗效和安全性。
{"title":"Pharmacological, ethnomedicinal, and evidence-based comparative review of Moringa oleifera Lam. (Shigru) and its potential role in the management of malnutrition in Tribal Regions of India, especially Chhattisgarh","authors":"P. Gupta, Kishor Sonewane, ShardaSwaroop Chouhan, M. Rajan, Nagendra Singh Chauhan, O. Rout, Awanish Kumar, G. Baghel","doi":"10.4103/wjtcm.wjtcm_69_21","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_69_21","url":null,"abstract":"Moringa oleifera Lam. (Shigru) (Moringaceae family) is a traditional medicine used for control of diabetes, obesity, asthma, and cardiac, liver, gastrointestinal, infective, and brain disorders, such as depression and Alzheimer's disease. In Ayurvedic literature, Shigru is among few drugs having Balya (nourishing) as well as Medohara (antiobesity) property. This review focuses on valid connections between the properties documented in ancient literature and current pharmacological knowledge of Moringa, including pharmacological actions, phytochemistry, botanical description, and how Moringa can tackle malnutrition in India, especially Chhattisgarh. All information about M. oleifera was obtained from electronic scientific databases such as PubMed, Web of Science, Scopus, ScienceDirect, Elsevier, Google Scholar, Traditional Knowledge Digital Library, and Indian Traditional Books (Ancient Ayurveda literatures, The Wealth of India, and The Ayurvedic Formulary of India), postgraduate/doctoral thesis, and googling the keyword M. oleifera. M. oleifera have anti-oxidant, antimicrobial, anti-diabetic, anti-obesity, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, gastroprotective, wound-healing properties and it can potentially tackle malnutrition. This review describes the key information related to botanical description of M. oleifera, phytochemistry, pharmacological actions, clinical studies, toxicological studies, better utilization as food therapeutics, and ethnobotanical and evidence-based comparative review of M. oleifera. M. oleifera can effectively tackle malnutrition in India, especially Chhattisgarh. The authors emphasize the need for future in-depth ethnopharmacological lead-based research and clinical studies to expand M. oleifera pharmacological activities, clinical efficacy, and safety.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44217512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/2311-8571.353502
Chang-liang Yao, Wen-long Wei, Jianqing Zhang, Qi-rui Bi, Jiayuan Li, I. Khan, R. Bauer, D. Guo
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, continues to be a global concern. Traditional Chinese medicines (TCMs) are an important element of the fight against COVID-19 in China. The combined application of TCMs and conventional medicines in the treatment of COVID-19 has achieved beneficial results, including the resolution of symptoms, prevention of disease progression, and reduced mortality. In this review, we summarize and discuss the current applications of TCMs with respect to COVID-19, as well as update the preclinical and clinical research, including chemical analysis, molecular mechanisms, quality control, drug development, and studies of clinical efficacy. The expectation is that a better understanding of the roles of TCMs against COVID-19 will improve the response to COVID-19, both in China and globally.
{"title":"Traditional Chinese medicines against COVID-19: A global overview","authors":"Chang-liang Yao, Wen-long Wei, Jianqing Zhang, Qi-rui Bi, Jiayuan Li, I. Khan, R. Bauer, D. Guo","doi":"10.4103/2311-8571.353502","DOIUrl":"https://doi.org/10.4103/2311-8571.353502","url":null,"abstract":"Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, continues to be a global concern. Traditional Chinese medicines (TCMs) are an important element of the fight against COVID-19 in China. The combined application of TCMs and conventional medicines in the treatment of COVID-19 has achieved beneficial results, including the resolution of symptoms, prevention of disease progression, and reduced mortality. In this review, we summarize and discuss the current applications of TCMs with respect to COVID-19, as well as update the preclinical and clinical research, including chemical analysis, molecular mechanisms, quality control, drug development, and studies of clinical efficacy. The expectation is that a better understanding of the roles of TCMs against COVID-19 will improve the response to COVID-19, both in China and globally.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48683378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/2311-8571.344543
Li-hong Chen, Yuanpeng Sun, H. Cai, Shuang Guo, Xiachang Wang, Wei-Dong Li, Chunqin Mao, Xun-hong Liu, Lin Yan, Heng-li Jiang, Tu-lin Lu
Objective: The aim of this study was to develop a reliable approach to simultaneously quantify 11 markers and explore the quality variation in honey-processed licorice. Materials and Methods: A high-performance liquid chromatography-diode array detector method was developed for the simultaneous determination of 11 markers (nine flavonoids and two triterpenoid saponins) in honey-processed licorice. The changes to the 11 markers in honey-processed licorice were investigated using an orthogonal design with three input factors. Results: The established method was precise, accurate, and sensitive enough for the simultaneous quantitative evaluation of 11 markers in honey-processed licorice. Intuitive analysis and variance analysis revealed that (1) the soaking time of crude licorice, stir-frying temperature, and stir-frying time remarkably influenced the content of liquiritin apioside, signifying the decomposition of liquiritin apioside to liquiritin or transformation of liquiritin apioside to isoliquiritin apioside, (2) stir-frying temperature significantly influenced licorice-saponin G2, (3) stir-frying temperature was the most important factor of the three input factors, (4) in terms of composition, honey fried licorice had significant effects on two components, namely liquiritin apioside and licorice-saponin G2. Conclusions: Honey processing influenced the content of the 11 licorice analytes differently. This paper highlights the first report on how the quality of honey-processed licorice varies under different processing conditions and suggests the optimal levels of the investigated three factors as A2B2C3 according to the degrees of influence of these factors on the 11 components. Specifically, the soaking time of crude licorice with honey solution, stir-frying temperature, and stir-frying time were 40 min, 100°C, and 20 min, respectively.
{"title":"Simultaneous determination of eleven bioactive constituents in honey-processed licorice by high-performance liquid chromatography-diode array detector and its application from the perspective of processing influence under orthogonal design","authors":"Li-hong Chen, Yuanpeng Sun, H. Cai, Shuang Guo, Xiachang Wang, Wei-Dong Li, Chunqin Mao, Xun-hong Liu, Lin Yan, Heng-li Jiang, Tu-lin Lu","doi":"10.4103/2311-8571.344543","DOIUrl":"https://doi.org/10.4103/2311-8571.344543","url":null,"abstract":"Objective: The aim of this study was to develop a reliable approach to simultaneously quantify 11 markers and explore the quality variation in honey-processed licorice. Materials and Methods: A high-performance liquid chromatography-diode array detector method was developed for the simultaneous determination of 11 markers (nine flavonoids and two triterpenoid saponins) in honey-processed licorice. The changes to the 11 markers in honey-processed licorice were investigated using an orthogonal design with three input factors. Results: The established method was precise, accurate, and sensitive enough for the simultaneous quantitative evaluation of 11 markers in honey-processed licorice. Intuitive analysis and variance analysis revealed that (1) the soaking time of crude licorice, stir-frying temperature, and stir-frying time remarkably influenced the content of liquiritin apioside, signifying the decomposition of liquiritin apioside to liquiritin or transformation of liquiritin apioside to isoliquiritin apioside, (2) stir-frying temperature significantly influenced licorice-saponin G2, (3) stir-frying temperature was the most important factor of the three input factors, (4) in terms of composition, honey fried licorice had significant effects on two components, namely liquiritin apioside and licorice-saponin G2. Conclusions: Honey processing influenced the content of the 11 licorice analytes differently. This paper highlights the first report on how the quality of honey-processed licorice varies under different processing conditions and suggests the optimal levels of the investigated three factors as A2B2C3 according to the degrees of influence of these factors on the 11 components. Specifically, the soaking time of crude licorice with honey solution, stir-frying temperature, and stir-frying time were 40 min, 100°C, and 20 min, respectively.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45956304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/2311-8571.351510
Xiao-wen Zhang, Yunpeng Gu, Huan-gan Wu, Kun Li, Rui Zhong, Qin Qi, Pin Wu, Jun-Hwan Ji, H. Liu, Yan Huang, Chang-Gue Son, Luyi Wu
Objective: The objective of this study is to systematically review and analyze the efficacy of acupuncture for pain caused by primary liver cancer (PLC). Materials and Methods: We searched databases, including PubMed, Medline, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Science and Technology Periodicals Database (VIP), Wanfang, and SinoMed/Chinese Biomedical Database (CBM), and retrieved randomized controlled trials (RCTs) that used acupuncture as the primary intervention to treat pain caused by PLC. Two investigators then screened the articles, extracted and pooled data, and evaluated the risk of bias of the included articles according to the Cochrane Handbook. RevMan5.3 was used for the meta-analysis of eligible RCTs. Results: A total of 145 articles were retrieved; after screening, 8 RCTs involving 496 patients were eventually included in this meta-analysis. The results showed that acupuncture effectively improved cancer pain and was superior to Western medicine. Moreover, acupuncture was fast-acting for pain relief, prolonged the relief, and prevented relapse. Its adverse reaction rate was also significantly lower than that of Western medicine. No significant difference was observed in Visual Analog Scale score between acupuncture and Western medicine. Conclusion: Acupuncture relieves pain caused by liver cancer and can be used as an adjunct and alternative therapy for drug treatment. The existing research evidence is not yet objective or comprehensive, and more rigorous clinical trials are needed to validate the results.
目的:系统回顾和分析针刺治疗原发性肝癌(PLC)疼痛的疗效。材料与方法:检索PubMed、Medline、Embase、Cochrane图书馆、Web of Science、中国国家知识基础设施、中国科技期刊数据库(VIP)、万方、中国生物医学数据库(CBM)等数据库，检索以针灸为主要干预手段治疗PLC引起疼痛的随机对照试验(RCTs)。两位研究者随后筛选文章，提取并汇总数据，并根据Cochrane手册评估纳入文章的偏倚风险。采用RevMan5.3对符合条件的随机对照试验进行meta分析。结果:共检索文献145篇;筛选后，8项随机对照试验共纳入496例患者。结果表明，针刺能有效改善癌痛，优于西医治疗。此外，针灸对疼痛的缓解作用迅速，缓解时间延长，防止复发。其不良反应发生率也明显低于西药。针刺与西药在视觉模拟量表评分上无显著差异。结论:针刺可减轻肝癌引起的疼痛，可作为药物治疗的辅助和替代疗法。现有的研究证据还不够客观和全面，需要更严格的临床试验来验证结果。
{"title":"Systematic review and meta-analysis of acupuncture for pain caused by liver cancer","authors":"Xiao-wen Zhang, Yunpeng Gu, Huan-gan Wu, Kun Li, Rui Zhong, Qin Qi, Pin Wu, Jun-Hwan Ji, H. Liu, Yan Huang, Chang-Gue Son, Luyi Wu","doi":"10.4103/2311-8571.351510","DOIUrl":"https://doi.org/10.4103/2311-8571.351510","url":null,"abstract":"Objective: The objective of this study is to systematically review and analyze the efficacy of acupuncture for pain caused by primary liver cancer (PLC). Materials and Methods: We searched databases, including PubMed, Medline, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Science and Technology Periodicals Database (VIP), Wanfang, and SinoMed/Chinese Biomedical Database (CBM), and retrieved randomized controlled trials (RCTs) that used acupuncture as the primary intervention to treat pain caused by PLC. Two investigators then screened the articles, extracted and pooled data, and evaluated the risk of bias of the included articles according to the Cochrane Handbook. RevMan5.3 was used for the meta-analysis of eligible RCTs. Results: A total of 145 articles were retrieved; after screening, 8 RCTs involving 496 patients were eventually included in this meta-analysis. The results showed that acupuncture effectively improved cancer pain and was superior to Western medicine. Moreover, acupuncture was fast-acting for pain relief, prolonged the relief, and prevented relapse. Its adverse reaction rate was also significantly lower than that of Western medicine. No significant difference was observed in Visual Analog Scale score between acupuncture and Western medicine. Conclusion: Acupuncture relieves pain caused by liver cancer and can be used as an adjunct and alternative therapy for drug treatment. The existing research evidence is not yet objective or comprehensive, and more rigorous clinical trials are needed to validate the results.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43117914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanghanlun is a classic work in traditional Chinese medicine (TCM), which systematically discusses diagnosis and treatment ideas based on syndrome differentiation and records a large number of highly practical prescriptions. When Shanghanlun was introduced into Japan along with the communication between China and Japan in the Sui and Tang Dynasties, it had a profound influence on the development of Kampo medicine in Japan. By sorting out the works related to Shanghanlun in the medical history literature of Kampo medicine before the Meiji Restoration, this paper discusses the relationship between Shanghanlun and the Koho school of Kampo medicine, as well as the influence of the thought “formula corresponding to pattern identification,” originating from the Koho school, on the development of modern Kampo medicine. The study of Shanghanlun by Kampo medicine nowadays not only attaches great importance to clinical practicality but also has theoretical discussions. It is expected that future medical exchanges between China and Japan will complement each other from the perspectives of both sides and promote the theoretical and clinical development of TCM.
{"title":"The influence of Shanghanlun on Japanese kampo medicine","authors":"Hiromichi Yasui, Liwu Zeng, Zhang Tao, Hui-Jun Wang, Kai Zhong, Lin-lin Shao, Guoqun Zhang","doi":"10.4103/2311-8571.344545","DOIUrl":"https://doi.org/10.4103/2311-8571.344545","url":null,"abstract":"Shanghanlun is a classic work in traditional Chinese medicine (TCM), which systematically discusses diagnosis and treatment ideas based on syndrome differentiation and records a large number of highly practical prescriptions. When Shanghanlun was introduced into Japan along with the communication between China and Japan in the Sui and Tang Dynasties, it had a profound influence on the development of Kampo medicine in Japan. By sorting out the works related to Shanghanlun in the medical history literature of Kampo medicine before the Meiji Restoration, this paper discusses the relationship between Shanghanlun and the Koho school of Kampo medicine, as well as the influence of the thought “formula corresponding to pattern identification,” originating from the Koho school, on the development of modern Kampo medicine. The study of Shanghanlun by Kampo medicine nowadays not only attaches great importance to clinical practicality but also has theoretical discussions. It is expected that future medical exchanges between China and Japan will complement each other from the perspectives of both sides and promote the theoretical and clinical development of TCM.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46734637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/2311-8571.353503
Nagendra Singh Chauhan, Sudha Porte, V. Joshi, K. Shah
The plant is a rich repository of useful secondary metabolites with profound medicinal potential. Saponins, one type of bioactive compound, are amphitheatric glycosides with one and more hydrophilic sugar and hydrophobic steroidal and terpenoid part. The former is known as steroidal saponin, and the latter is called terpenoid saponins. Steroidal saponin is mostly distributed among monocotyledon families such as Asparagaceae, Amaryllidaceae, Dioscoreaceae, Smilacaceae, and Liliaceae. Even though it is unusual, it could also be detected to some extent by dicotyledonous angiosperms, such as Plantaginaceae, Zygophyllaceae, Fabaceae, Asteraceae, and Solanaceae. It exhibits diverse pharmacological ability including antimicrobic, anti-inflammatory, cAMP phosphodiesterase inhibitory, antiadipogenic, bactericide, cardioprotective, antitumor, antidiabetic, cytotoxic activity, antifungal, antiviral, antioxidant, and hepatoprotective. Steroidal saponin timosaponin AIII from Anemarrhena asphodeloides has been found to possess antitumor activity. Diosgenin, another steroidal sapogenin, has the potential of preventing neurological diseases by affecting different signaling pathways, increasing bone formation, and increasing antithrombotic activity. Spicatoside A from Liriope platyphylla possesses anti-inflammatory, antiasthma, and antiosteoclastogenic activities. TTB2 from Trillium tschonoskii exhibits anticancer potential. The cell cycle arrest and ROS-dependent autophagy are induced by polyphyllin I. These diverse biological activities of steroidal saponins are attributed to the variability of their structural features. Analysis of steroidal saponins in plant materials mainly utilizes classically and advances thin layer chromatography (TLC) on normal and reverses-phase (high-performance thin-layer chromatography, densitometric TLC), gas chromatography, LC, UPLC, ultra-high-performance liquid chromatography (HPLC), supercritical fluid chromatography, and HPLC coupled to ultraviolet detector and diode array detector. HPLC coupled with MS and Nuclear magnetic resonance is used for online identification of separated saponins. The present review aims to furnish a comprehensive account of the recent advances in analytical methods of determination and medicinal applications of steroidal saponins.
{"title":"Plants' steroidal saponins - A review on its pharmacology properties and analytical techniques","authors":"Nagendra Singh Chauhan, Sudha Porte, V. Joshi, K. Shah","doi":"10.4103/2311-8571.353503","DOIUrl":"https://doi.org/10.4103/2311-8571.353503","url":null,"abstract":"The plant is a rich repository of useful secondary metabolites with profound medicinal potential. Saponins, one type of bioactive compound, are amphitheatric glycosides with one and more hydrophilic sugar and hydrophobic steroidal and terpenoid part. The former is known as steroidal saponin, and the latter is called terpenoid saponins. Steroidal saponin is mostly distributed among monocotyledon families such as Asparagaceae, Amaryllidaceae, Dioscoreaceae, Smilacaceae, and Liliaceae. Even though it is unusual, it could also be detected to some extent by dicotyledonous angiosperms, such as Plantaginaceae, Zygophyllaceae, Fabaceae, Asteraceae, and Solanaceae. It exhibits diverse pharmacological ability including antimicrobic, anti-inflammatory, cAMP phosphodiesterase inhibitory, antiadipogenic, bactericide, cardioprotective, antitumor, antidiabetic, cytotoxic activity, antifungal, antiviral, antioxidant, and hepatoprotective. Steroidal saponin timosaponin AIII from Anemarrhena asphodeloides has been found to possess antitumor activity. Diosgenin, another steroidal sapogenin, has the potential of preventing neurological diseases by affecting different signaling pathways, increasing bone formation, and increasing antithrombotic activity. Spicatoside A from Liriope platyphylla possesses anti-inflammatory, antiasthma, and antiosteoclastogenic activities. TTB2 from Trillium tschonoskii exhibits anticancer potential. The cell cycle arrest and ROS-dependent autophagy are induced by polyphyllin I. These diverse biological activities of steroidal saponins are attributed to the variability of their structural features. Analysis of steroidal saponins in plant materials mainly utilizes classically and advances thin layer chromatography (TLC) on normal and reverses-phase (high-performance thin-layer chromatography, densitometric TLC), gas chromatography, LC, UPLC, ultra-high-performance liquid chromatography (HPLC), supercritical fluid chromatography, and HPLC coupled to ultraviolet detector and diode array detector. HPLC coupled with MS and Nuclear magnetic resonance is used for online identification of separated saponins. The present review aims to furnish a comprehensive account of the recent advances in analytical methods of determination and medicinal applications of steroidal saponins.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45965678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/wjtcm.wjtcm_1_22
Li Lin, Lian-lin Su, Huan-huan Li, Chunqin Mao, De Ji, Hui Xie, Tu-lin Lu
Objective: The objective of the study is to combine network pharmacology with high-performance liquid chromatography (HPLC) to screen for quality markers (Q-markers) of Inulae Flos and predict mechanism on anti-hepatitis. Materials and Methods: Active ingredient library of Inulae Flos is structured using databases and the literature. “Compound-target-pathway” network on anti-hepatitis and protein–protein interaction (PPI) network are constructed using network pharmacology. Next, chromatographic fingerprints of Inulae Flos in 7 origins are obtained through HPLC, and chemometric analysis is implemented to identify chemical markers, which is combined with network pharmacology to identify Q-markers and detect content. Results: 1,6-O, O-Diacetylbritannilactone, Ivangustin, and Inulanolide A are key ingredients of Inulae Flos to interact with 82 potential targets related to anti-hepatitis. Furthermore, signal transducer and activator of transcription 3, tumor necrosis factor, interleukin-6, and transcription factor AP-1 are the core targets in the PPI network. Chromatographic fingerprints of the Inulae Flos define 20 common peaks and identify 8 peaks using reference substances. Through partial least square discriminant analysis, 7 compounds including caffeic acid, chlorogenic acid, and 1,6-O, O-Diacetylbritannilactone were main chemical markers for variability. 1,6-O, O-Diacetylbritannilactone is both a key ingredient and exclusive chemical marker. Therefore, 1,6-O, O-diacetylbritannilactone is a Q-marker of Inulae Flos, and the average content is 1.82 mg/g. Conclusion: 1,6-O, O-diacetylbritannilactone is determined to be a Q-marker of Inulae Flos.
{"title":"Study on quality markers and action mechanisms of inulae flos on anti-hepatitis through network pharmacology and high-performance liquid chromatography fingerprints","authors":"Li Lin, Lian-lin Su, Huan-huan Li, Chunqin Mao, De Ji, Hui Xie, Tu-lin Lu","doi":"10.4103/wjtcm.wjtcm_1_22","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_1_22","url":null,"abstract":"Objective: The objective of the study is to combine network pharmacology with high-performance liquid chromatography (HPLC) to screen for quality markers (Q-markers) of Inulae Flos and predict mechanism on anti-hepatitis. Materials and Methods: Active ingredient library of Inulae Flos is structured using databases and the literature. “Compound-target-pathway” network on anti-hepatitis and protein–protein interaction (PPI) network are constructed using network pharmacology. Next, chromatographic fingerprints of Inulae Flos in 7 origins are obtained through HPLC, and chemometric analysis is implemented to identify chemical markers, which is combined with network pharmacology to identify Q-markers and detect content. Results: 1,6-O, O-Diacetylbritannilactone, Ivangustin, and Inulanolide A are key ingredients of Inulae Flos to interact with 82 potential targets related to anti-hepatitis. Furthermore, signal transducer and activator of transcription 3, tumor necrosis factor, interleukin-6, and transcription factor AP-1 are the core targets in the PPI network. Chromatographic fingerprints of the Inulae Flos define 20 common peaks and identify 8 peaks using reference substances. Through partial least square discriminant analysis, 7 compounds including caffeic acid, chlorogenic acid, and 1,6-O, O-Diacetylbritannilactone were main chemical markers for variability. 1,6-O, O-Diacetylbritannilactone is both a key ingredient and exclusive chemical marker. Therefore, 1,6-O, O-diacetylbritannilactone is a Q-marker of Inulae Flos, and the average content is 1.82 mg/g. Conclusion: 1,6-O, O-diacetylbritannilactone is determined to be a Q-marker of Inulae Flos.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41911450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.4103/wjtcm.wjtcm_76_21
Xiang Wang, Xinran Liu, Ke-xin Li, Xiang-hui Fan, Yang Liu
Ferulic acid (FA) is a phenolic phytochemical with antioxidant and anti-inflammatory pharmacological effects. In recent years, the neuroprotective effects of FA have been studied extensively. Many researchers have attempted to use FA to prevent and treat neurological diseases and have made some progress. This paper mainly collated the study of the protective effect of FA on stroke and summarized the protective effect of FA on ischemic stroke and the potential protective effects of FA on neurovascular units.
{"title":"Effects of ferulic acid on regulating the neurovascular unit: Implications for ischemic stroke treatment","authors":"Xiang Wang, Xinran Liu, Ke-xin Li, Xiang-hui Fan, Yang Liu","doi":"10.4103/wjtcm.wjtcm_76_21","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_76_21","url":null,"abstract":"Ferulic acid (FA) is a phenolic phytochemical with antioxidant and anti-inflammatory pharmacological effects. In recent years, the neuroprotective effects of FA have been studied extensively. Many researchers have attempted to use FA to prevent and treat neurological diseases and have made some progress. This paper mainly collated the study of the protective effect of FA on stroke and summarized the protective effect of FA on ischemic stroke and the potential protective effects of FA on neurovascular units.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47231314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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