{"title":"Artificial intelligence and network pharmacology reveal the medication rules of Professor Wang Yu-Ying in the treatment of climacteric syndrome","authors":"Yu-Ying Wang, Yi Lu, Mengqui Hu, Tian-Xing Yi, Qi-Rui Liu, Xin-Yu Zhang, Ai-ping Chen","doi":"10.4103/2311-8571.382287","DOIUrl":"https://doi.org/10.4103/2311-8571.382287","url":null,"abstract":"","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70433100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/2311-8571.355010
Hongxuan Wu, Weichang Dai, Libo Wang, Jie Zhang, Chenglong Wang
Objective: To explore the regulatory mechanism of competitive endogenous RNAs (ceRNA) in gastric cancer (GC) and to predict the prognosis of GC. Materials and Methods: Expression profiles of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs were obtained from The Cancer Genome Atlas platform. Differentially expressed RNAs (DERNAs) were screened to construct a lncRNA-miRNA-mRNA ceRNA network. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed on the ceRNA network-related differentially expressed mRNAs (DEmRNAs). Next, the DERNAs were subjected to Cox regression and survival analyses to identify crucial prognostic factors for patients with GC. Results: We detected 1029 differentially expressed lncRNAs, 104 differentially expressed miRNAs, and 1659 DEmRNAs in patients with GC. Next, we performed bioinformatic analysis to construct the lncRNA-miRNA-mRNA ceRNA network, which included 10 miRNAs, 65 lncRNAs, and 10 mRNAs. Subsequently, KaplanMeier (K-M) analysis showed that the survival rate of the high-risk group was significantly lower than that of the low-risk group, and the area under the curve value of the receiver operating characteristic curve revealed that the polygenic model had good predictive ability. The results indicated that ADAMTS9-AS1, ATAD2, and CADM2 might be potential therapeutic targets and prognostic biomarkers for GC. Conclusions: Our study has implications for predicting prognosis and monitoring surveillance of GC and provides a new theoretical and experimental basis for the clinical prognosis of GC.
{"title":"Comprehensive analysis of the molecular mechanism for gastric cancer based on competitive endogenous RNA network","authors":"Hongxuan Wu, Weichang Dai, Libo Wang, Jie Zhang, Chenglong Wang","doi":"10.4103/2311-8571.355010","DOIUrl":"https://doi.org/10.4103/2311-8571.355010","url":null,"abstract":"Objective: To explore the regulatory mechanism of competitive endogenous RNAs (ceRNA) in gastric cancer (GC) and to predict the prognosis of GC. Materials and Methods: Expression profiles of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs were obtained from The Cancer Genome Atlas platform. Differentially expressed RNAs (DERNAs) were screened to construct a lncRNA-miRNA-mRNA ceRNA network. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed on the ceRNA network-related differentially expressed mRNAs (DEmRNAs). Next, the DERNAs were subjected to Cox regression and survival analyses to identify crucial prognostic factors for patients with GC. Results: We detected 1029 differentially expressed lncRNAs, 104 differentially expressed miRNAs, and 1659 DEmRNAs in patients with GC. Next, we performed bioinformatic analysis to construct the lncRNA-miRNA-mRNA ceRNA network, which included 10 miRNAs, 65 lncRNAs, and 10 mRNAs. Subsequently, KaplanMeier (K-M) analysis showed that the survival rate of the high-risk group was significantly lower than that of the low-risk group, and the area under the curve value of the receiver operating characteristic curve revealed that the polygenic model had good predictive ability. The results indicated that ADAMTS9-AS1, ATAD2, and CADM2 might be potential therapeutic targets and prognostic biomarkers for GC. Conclusions: Our study has implications for predicting prognosis and monitoring surveillance of GC and provides a new theoretical and experimental basis for the clinical prognosis of GC.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46663305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/2311-8571.382074
Yang Sun, Hai-Bo Cheng, W-F Lv, Mingfen Zhao, C. Song, Qin-Chang Zhang, Hao-Jie Du, Shu-Qiong Zhang, Yu Shen
{"title":"Network pharmacology of xian-lian-jie-du decoction in ameliorating colorectal cancer","authors":"Yang Sun, Hai-Bo Cheng, W-F Lv, Mingfen Zhao, C. Song, Qin-Chang Zhang, Hao-Jie Du, Shu-Qiong Zhang, Yu Shen","doi":"10.4103/2311-8571.382074","DOIUrl":"https://doi.org/10.4103/2311-8571.382074","url":null,"abstract":"","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70433059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/2311-8571.372731
Hua Zhou, Yi-Ran Hu, Hui-Yan Qu, Jia-Ying Guo, Tao Yang
Objective: This study explored the myocardial protection role of Jujuboside A through an ischemia–hypoxia–reperfusion (IHR) model. Materials and Methods: H9c2 cells were induced by D-galactose (D-gal) and IHR to establish an aging and IHR model. There are four groups of experiments: Control, IHR, D-gal + IHR, and D-gal + IHR + Jujuboside A. Cells viability, Adenosine triphosphate (ATP), reactive oxygen species (ROS), nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide hydride (NADH) content, and NAD+/NADH ratio were detected using biochemical methods. Inflammatory cytokines level was detected by enzyme-linked immunosorbent assay. The expression of CD38, Recombinant NLR Family, pyrin domain-containing protein 3 (NLRP3), and silent mating type information regulation 2 homolog 3 (SIRT3) protein was detected by Western blotting. Results: Compared to the IHR group, cell viability, ATP content, NAD + content, NAD+/NADH ratio, and SIRT3 protein expression decreased, ROS level and inflammatory cytokines increased, and CD38 and NLRP3 proteins raised in the D-gal + IHR group. Compared to the D-gal + IHR group, cell viability, ATP content, NAD + content, NAD+/NADH ratio, and expression of SIRT3 protein increased, ROS level and inflammatory cytokines level decreased, and expression of the CD38 and NLRP3 proteins decreased in the D-gal + IHR + Jujuboside A group. Conclusions: Jujuboside A inhibited the expression of CD38, improved energy metabolism disorder, and mitochondrial function, and decreased inflammation in D-gal-induced H9c2 cells.
{"title":"Jujuboside a improved energy metabolism in senescent H9c2 cells injured by ischemia, hypoxia, and reperfusion through the CD38/Silent mating type information regulation 2 homolog 3 signaling pathway","authors":"Hua Zhou, Yi-Ran Hu, Hui-Yan Qu, Jia-Ying Guo, Tao Yang","doi":"10.4103/2311-8571.372731","DOIUrl":"https://doi.org/10.4103/2311-8571.372731","url":null,"abstract":"Objective: This study explored the myocardial protection role of Jujuboside A through an ischemia–hypoxia–reperfusion (IHR) model. Materials and Methods: H9c2 cells were induced by D-galactose (D-gal) and IHR to establish an aging and IHR model. There are four groups of experiments: Control, IHR, D-gal + IHR, and D-gal + IHR + Jujuboside A. Cells viability, Adenosine triphosphate (ATP), reactive oxygen species (ROS), nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide hydride (NADH) content, and NAD+/NADH ratio were detected using biochemical methods. Inflammatory cytokines level was detected by enzyme-linked immunosorbent assay. The expression of CD38, Recombinant NLR Family, pyrin domain-containing protein 3 (NLRP3), and silent mating type information regulation 2 homolog 3 (SIRT3) protein was detected by Western blotting. Results: Compared to the IHR group, cell viability, ATP content, NAD + content, NAD+/NADH ratio, and SIRT3 protein expression decreased, ROS level and inflammatory cytokines increased, and CD38 and NLRP3 proteins raised in the D-gal + IHR group. Compared to the D-gal + IHR group, cell viability, ATP content, NAD + content, NAD+/NADH ratio, and expression of SIRT3 protein increased, ROS level and inflammatory cytokines level decreased, and expression of the CD38 and NLRP3 proteins decreased in the D-gal + IHR + Jujuboside A group. Conclusions: Jujuboside A inhibited the expression of CD38, improved energy metabolism disorder, and mitochondrial function, and decreased inflammation in D-gal-induced H9c2 cells.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/2311-8571.364413
Abhishek Kumar, A. Vimal, Awanish Kumar
Background: Traditional plants, their parts, and phytochemicals obtained from them are beneficial for human beings. They are used as potent antimicrobials, but very little research is conducted on the use of traditional medicine against food-borne infection. Different berry plants are rich in phenolic compounds and conventionally known to have many properties such as antioxidants, anti-carcinogenic, anti-inflammatory, anti-bacterial, and anti-diabetics. However, only limited polyphenols are known for their antilisterial effect. The present study aimed to explore the antimicrobial efficacy of phenolic compounds of berries for the treatment of food-borne infection caused by the bacteria Listeria monocytogenes. Materials and Methods: Molecular docking studies employing the SwissDOCK server were performed to evaluate the antimicrobial activity of phenolic compounds obtained from different varieties of berries. Internalin B (InlB), a virulence protein of L. monocytogenes was selected as a target. The absorption, distribution, metabolism, excretion, and toxicity profiling of each test ligand was done through the SwissADME tool. Results: Among all the test ligands, p-coumaric acid, epicatechins, chlorogenic acid, and quercetin showed better binding efficiency with the target protein InlB. The binding energy obtained for quercetin, p-coumaric acid, chlorogenic acid, and epicatechins was-8.93,-8.23,-8.18,-7.58, kcal/mol, respectively. Quercetin and p-coumaric acid were forming 4 H-bonds, whereas chlorogenic acid and epicatechins were forming 3-H bonds inside the binding pocket. Conclusion: In a nutshell, analyses indicated that identified ligands have the potential to block the virulent protein InlB of L. monocytogenes and help combat Listeria infection. These phenolic compounds could be a substitute for synthetic antimicrobials and can be used in food preservation and combat food-borne diseases. However, future in-depth in vitro and in vivo analysis is needed to get more information on these four phenolic ligands of berries.
{"title":"Inhibitory interaction and pharmacological analyses of berries phenolics against Listeria monocytogenes virulent protein internalin B","authors":"Abhishek Kumar, A. Vimal, Awanish Kumar","doi":"10.4103/2311-8571.364413","DOIUrl":"https://doi.org/10.4103/2311-8571.364413","url":null,"abstract":"Background: Traditional plants, their parts, and phytochemicals obtained from them are beneficial for human beings. They are used as potent antimicrobials, but very little research is conducted on the use of traditional medicine against food-borne infection. Different berry plants are rich in phenolic compounds and conventionally known to have many properties such as antioxidants, anti-carcinogenic, anti-inflammatory, anti-bacterial, and anti-diabetics. However, only limited polyphenols are known for their antilisterial effect. The present study aimed to explore the antimicrobial efficacy of phenolic compounds of berries for the treatment of food-borne infection caused by the bacteria Listeria monocytogenes. Materials and Methods: Molecular docking studies employing the SwissDOCK server were performed to evaluate the antimicrobial activity of phenolic compounds obtained from different varieties of berries. Internalin B (InlB), a virulence protein of L. monocytogenes was selected as a target. The absorption, distribution, metabolism, excretion, and toxicity profiling of each test ligand was done through the SwissADME tool. Results: Among all the test ligands, p-coumaric acid, epicatechins, chlorogenic acid, and quercetin showed better binding efficiency with the target protein InlB. The binding energy obtained for quercetin, p-coumaric acid, chlorogenic acid, and epicatechins was-8.93,-8.23,-8.18,-7.58, kcal/mol, respectively. Quercetin and p-coumaric acid were forming 4 H-bonds, whereas chlorogenic acid and epicatechins were forming 3-H bonds inside the binding pocket. Conclusion: In a nutshell, analyses indicated that identified ligands have the potential to block the virulent protein InlB of L. monocytogenes and help combat Listeria infection. These phenolic compounds could be a substitute for synthetic antimicrobials and can be used in food preservation and combat food-borne diseases. However, future in-depth in vitro and in vivo analysis is needed to get more information on these four phenolic ligands of berries.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42902108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/wjtcm.wjtcm_12_22
Dong Wu, Yan-Ling Zhao, Ru-Jun Dai, P. Rong, Yu Wang
Photobiomodulation (PBM) therapy is a therapeutic method that can produce a range of physiological effects in cells and tissues using certain wavelengths. The reparative benefits of PBM therapy include wound healing, bone regeneration, pain reduction, and the mitigation of inflammation. Advances in the development of laser instruments, including the use of high-intensity lasers in physiotherapy, have recently led to controllable photothermal and photomechanical treatments that enable therapeutic effects to be obtained without damaging tissue. The combination of PBM therapy with acupuncture may provide new perspectives for investigating the underlying therapeutic mechanisms of acupuncture and promote its widespread application.
{"title":"Application of photobiomodulation therapy in acupuncture","authors":"Dong Wu, Yan-Ling Zhao, Ru-Jun Dai, P. Rong, Yu Wang","doi":"10.4103/wjtcm.wjtcm_12_22","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_12_22","url":null,"abstract":"Photobiomodulation (PBM) therapy is a therapeutic method that can produce a range of physiological effects in cells and tissues using certain wavelengths. The reparative benefits of PBM therapy include wound healing, bone regeneration, pain reduction, and the mitigation of inflammation. Advances in the development of laser instruments, including the use of high-intensity lasers in physiotherapy, have recently led to controllable photothermal and photomechanical treatments that enable therapeutic effects to be obtained without damaging tissue. The combination of PBM therapy with acupuncture may provide new perspectives for investigating the underlying therapeutic mechanisms of acupuncture and promote its widespread application.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42791814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/2311-8571.326075
Lei Peng, Lin-Kun Ma, Qianqian Jiang, Xue Tian, Mingyan Shao, Changxiang Li, Xiaoqian Sun, Xiao Ma, Xu Chen, Chun Xing Li
Objective: This study aimed to explore the mechanism of Panax notoginseng (PNS) in the treatment of heart failure (HF) based on network pharmacology analysis combined with experimental verification. Materials and Methods: The potential targets and key pathways of effective components of PNS in the treatment of HF were revealed using network pharmacology. The postacute myocardial infarction (MI) HF rat model was established by ligating the left anterior descending branch of the coronary artery. The rats were divided into three groups: model, PNS, and fenofibrate groups. PNS (0.75 g/kg) and fenofibrate (10 mg/kg) were administered for 28 days. The efficacy and target mechanism of PNS in the treatment of HF were verified by cardiac ultrasound, Masson staining, and western blotting (WB) techniques. Results: The results of network pharmacology showed that seven potentially active compounds, such as quercetin, were obtained, involving 105 targets of HF; GO function was enriched to 1240 items; and KEGG enrichment covered 1240 signal pathways. The results of echocardiography showed that EF and FS of HF rats after MI were significantly increased, while Left ventricular internal dimension diastole (LVIDd) and Left ventricular internal dimension systole (LVIDs) were significantly decreased (P < 0.001, P < 0.05). Masson staining showed that PNS could reduce the degree of myocardial fibrosis (MF) in HF. The results of WB showed that PNS could reduce the expression of the p-p38-MAPK, transforming growth factor-beta (TGF-β), and Smad3 in HF rats. Conclusion: PNS inhibited MF and treated HF by regulating p-p38 MAPK-TGF-β pathway, which lays a theoretical foundation for further study of its pharmacological mechanism and key target.
{"title":"The mechanism of Panax Notoginseng in the treatment of heart failure based on biological analysis","authors":"Lei Peng, Lin-Kun Ma, Qianqian Jiang, Xue Tian, Mingyan Shao, Changxiang Li, Xiaoqian Sun, Xiao Ma, Xu Chen, Chun Xing Li","doi":"10.4103/2311-8571.326075","DOIUrl":"https://doi.org/10.4103/2311-8571.326075","url":null,"abstract":"Objective: This study aimed to explore the mechanism of Panax notoginseng (PNS) in the treatment of heart failure (HF) based on network pharmacology analysis combined with experimental verification. Materials and Methods: The potential targets and key pathways of effective components of PNS in the treatment of HF were revealed using network pharmacology. The postacute myocardial infarction (MI) HF rat model was established by ligating the left anterior descending branch of the coronary artery. The rats were divided into three groups: model, PNS, and fenofibrate groups. PNS (0.75 g/kg) and fenofibrate (10 mg/kg) were administered for 28 days. The efficacy and target mechanism of PNS in the treatment of HF were verified by cardiac ultrasound, Masson staining, and western blotting (WB) techniques. Results: The results of network pharmacology showed that seven potentially active compounds, such as quercetin, were obtained, involving 105 targets of HF; GO function was enriched to 1240 items; and KEGG enrichment covered 1240 signal pathways. The results of echocardiography showed that EF and FS of HF rats after MI were significantly increased, while Left ventricular internal dimension diastole (LVIDd) and Left ventricular internal dimension systole (LVIDs) were significantly decreased (P < 0.001, P < 0.05). Masson staining showed that PNS could reduce the degree of myocardial fibrosis (MF) in HF. The results of WB showed that PNS could reduce the expression of the p-p38-MAPK, transforming growth factor-beta (TGF-β), and Smad3 in HF rats. Conclusion: PNS inhibited MF and treated HF by regulating p-p38 MAPK-TGF-β pathway, which lays a theoretical foundation for further study of its pharmacological mechanism and key target.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46741402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/2311-8571.355593
Yinglin Zhong
Background: Ginkgo biloba L. is listed in the Red List of Endangered Species by the International Union for Conservation of Nature. G. biloba is an important medicinal plant in China and can be widely used in materials, gardens, and as a source of nutrients. With the large-scale planting of ginkgo plants, China, accounts for more than 70% of the world's total gingko output. Currently, G. biloba P. E. is the main extract under product development and application. However, G. biloba has been discarded as waste for a long time and has not been well developed and utilized. According to incomplete statistics, nearly 40,000 tons are discarded in China every year, which not only wastes resources but also pollutes the environment. Objective: This is an issue of great significance and adds value to scientific research. We aim to develop a key technology for resource recycling by combining G. biloba waste resources and waste treatment. Methods: Data were obtained by searching databases such as CNKI, and analyzing the herb application, modern application, main chemical components, utilization of waste parts, ways and modes combined with waste treatment, and safety of G. biloba. This systematic analysis can serve as a reference for the recycling of waste resources in other fields. Conclusion: The chemical constituents of the outer seed coat of G. biloba mainly include hydrophenols, phenolic acids, and biflavones, among which the phenolic acid of G. biloba can be used to extract glycolic acid, which can inhibit Mycobacterium tuberculosis. The domestic waste produced by tuberculosis (TB) patients contains a large number of bacilli, and the incidence of transmission can be reduced by using glycolic acid to inhibit the growth of TB bacilli in the waste.
{"title":"Ginkgo biloba waste resources and waste treatment combined with modern progress and development model","authors":"Yinglin Zhong","doi":"10.4103/2311-8571.355593","DOIUrl":"https://doi.org/10.4103/2311-8571.355593","url":null,"abstract":"Background: Ginkgo biloba L. is listed in the Red List of Endangered Species by the International Union for Conservation of Nature. G. biloba is an important medicinal plant in China and can be widely used in materials, gardens, and as a source of nutrients. With the large-scale planting of ginkgo plants, China, accounts for more than 70% of the world's total gingko output. Currently, G. biloba P. E. is the main extract under product development and application. However, G. biloba has been discarded as waste for a long time and has not been well developed and utilized. According to incomplete statistics, nearly 40,000 tons are discarded in China every year, which not only wastes resources but also pollutes the environment. Objective: This is an issue of great significance and adds value to scientific research. We aim to develop a key technology for resource recycling by combining G. biloba waste resources and waste treatment. Methods: Data were obtained by searching databases such as CNKI, and analyzing the herb application, modern application, main chemical components, utilization of waste parts, ways and modes combined with waste treatment, and safety of G. biloba. This systematic analysis can serve as a reference for the recycling of waste resources in other fields. Conclusion: The chemical constituents of the outer seed coat of G. biloba mainly include hydrophenols, phenolic acids, and biflavones, among which the phenolic acid of G. biloba can be used to extract glycolic acid, which can inhibit Mycobacterium tuberculosis. The domestic waste produced by tuberculosis (TB) patients contains a large number of bacilli, and the incidence of transmission can be reduced by using glycolic acid to inhibit the growth of TB bacilli in the waste.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43546408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/2311-8571.351511
Xin-Yuan Liu, Jinghua Li, Ying-Hui Wang, Lim Weihan, Yi-Meng Wang, Ye Tian, Yan Huang, Shaolei Tian, Qi Yu
Objective: This study analyzed the data of the medical cases in the book, “Clinical Guide Medical records” using a data mining method, to provide a reference for Ye Tianshi's academic thoughts. Methods: We used the web version of the ancient and modern medical records cloud platform to complete distribution statistics, association rules, cluster analysis, and complex network analysis of all the medical records in the “Clinical Guide Medical records.” These methods were used to summarize the baseline data and to identify the core relationship between Chinese medicine diseases and Chinese medicine, as well as the Chinese medicine Classification. Results: A total of 2572 medical records, 3136 visits, and 2879 prescriptions of 1127 traditional Chinese medicines were included in this study. The most common diseases (such as hematemesis), syndromes (such as liver–stomach disharmony), symptoms (such as rapid pulse), disease sites (such as gastric cavity), disease properties (such as Yang deficiency), treatment methods (such as activating Yang), and traditional Chinese medicines (such as Poria cocos) were identified. Furthermore, medicines with a warm, flat, cold, sweet, or bitter taste with its effects on the lungs, spleen, and heart were the most common. The observed effects of the drugs included clearing dampness, promoting diuresis, and strengthening the spleen. The association analysis showed that the associations between TCM diseases and traditional Chinese medicines that had a high confidence were “phlegm and fluid retention–Poria cocos,” “diarrhea–Poria cocos,” etc. The cluster analysis showed that traditional Chinese medicines were classified into five categories. The complex network showed the core relationship between nine high-frequency diseases and nine high-frequency traditional Chinese medicine. Conclusion: This study revealed the most important relationships between traditional Chinese medicines diseases and traditional Chinese medicines and classified the most used traditional Chinese medicines. These findings may help the coming generations of doctors to make accurate diagnoses and treat patients effectively and to improve the clinicians' efficacy in clinical diagnosis and treatment.
{"title":"Application of the data mining algorithm in the clinical guide medical records","authors":"Xin-Yuan Liu, Jinghua Li, Ying-Hui Wang, Lim Weihan, Yi-Meng Wang, Ye Tian, Yan Huang, Shaolei Tian, Qi Yu","doi":"10.4103/2311-8571.351511","DOIUrl":"https://doi.org/10.4103/2311-8571.351511","url":null,"abstract":"Objective: This study analyzed the data of the medical cases in the book, “Clinical Guide Medical records” using a data mining method, to provide a reference for Ye Tianshi's academic thoughts. Methods: We used the web version of the ancient and modern medical records cloud platform to complete distribution statistics, association rules, cluster analysis, and complex network analysis of all the medical records in the “Clinical Guide Medical records.” These methods were used to summarize the baseline data and to identify the core relationship between Chinese medicine diseases and Chinese medicine, as well as the Chinese medicine Classification. Results: A total of 2572 medical records, 3136 visits, and 2879 prescriptions of 1127 traditional Chinese medicines were included in this study. The most common diseases (such as hematemesis), syndromes (such as liver–stomach disharmony), symptoms (such as rapid pulse), disease sites (such as gastric cavity), disease properties (such as Yang deficiency), treatment methods (such as activating Yang), and traditional Chinese medicines (such as Poria cocos) were identified. Furthermore, medicines with a warm, flat, cold, sweet, or bitter taste with its effects on the lungs, spleen, and heart were the most common. The observed effects of the drugs included clearing dampness, promoting diuresis, and strengthening the spleen. The association analysis showed that the associations between TCM diseases and traditional Chinese medicines that had a high confidence were “phlegm and fluid retention–Poria cocos,” “diarrhea–Poria cocos,” etc. The cluster analysis showed that traditional Chinese medicines were classified into five categories. The complex network showed the core relationship between nine high-frequency diseases and nine high-frequency traditional Chinese medicine. Conclusion: This study revealed the most important relationships between traditional Chinese medicines diseases and traditional Chinese medicines and classified the most used traditional Chinese medicines. These findings may help the coming generations of doctors to make accurate diagnoses and treat patients effectively and to improve the clinicians' efficacy in clinical diagnosis and treatment.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47176340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/2311-8571.355594
Yong Jiang, Yaodan Chang, M. Wang, Yan-ping Sun, Yuelin Bi, Zhibin Wang, H. Kuang
Objective: The objective of this study was to study the mechanism of Radix Astragali on colon cancer by integrated pharmacology and molecular docking technique. Methods: Integrative pharmacology-based research platform of traditional Chinese medicine (TCMIP) V2.0 was used to obtain the chemical components and corresponding targets of Radix Astragali and the target information of colon cancer to create the main target network of drugs and diseases. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was carried out using Hiplot website, and the interaction network of “Traditional Chinese Medicine-component-target-pathway” was established, and molecular docking with main targets was carried out for the key components. Results: Twenty-seven chemical constituents of Radix Astragali, their 254 corresponding targets, and 44 colon cancer-related targets were obtained. Through proteins interacting, 70 nodes were obtained as core targets. GO analysis showed that it mainly acts on lipid metabolism, nuclear receptor activity, phagocytic cup, etc. KEGG pathway analysis showed that it was mainly enriched in the estrogen signaling pathway, C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway, etc. The multidimensional network, quantitative estimate of the drug, and molecular docking showed that the main targets are AKT1, BCL2, and CDK6, and the key components involved are kumatakenin, astragaloside VIII, and choline. Conclusion: Kumatakenin, Astragaloside VIII, Choline and other compounds of Radix Astragali may affect colon cancer by acting on AKT1, BCL2 and other targets, thereby regulating estrogen signaling pathway, C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway and so on. Those will provide theoretical reference for future research on the material basis and mechanism of its pharmacodynamics.
{"title":"Exploring the molecular mechanism of Radix Astragali on colon cancer based on integrated pharmacology and molecular docking technique","authors":"Yong Jiang, Yaodan Chang, M. Wang, Yan-ping Sun, Yuelin Bi, Zhibin Wang, H. Kuang","doi":"10.4103/2311-8571.355594","DOIUrl":"https://doi.org/10.4103/2311-8571.355594","url":null,"abstract":"Objective: The objective of this study was to study the mechanism of Radix Astragali on colon cancer by integrated pharmacology and molecular docking technique. Methods: Integrative pharmacology-based research platform of traditional Chinese medicine (TCMIP) V2.0 was used to obtain the chemical components and corresponding targets of Radix Astragali and the target information of colon cancer to create the main target network of drugs and diseases. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was carried out using Hiplot website, and the interaction network of “Traditional Chinese Medicine-component-target-pathway” was established, and molecular docking with main targets was carried out for the key components. Results: Twenty-seven chemical constituents of Radix Astragali, their 254 corresponding targets, and 44 colon cancer-related targets were obtained. Through proteins interacting, 70 nodes were obtained as core targets. GO analysis showed that it mainly acts on lipid metabolism, nuclear receptor activity, phagocytic cup, etc. KEGG pathway analysis showed that it was mainly enriched in the estrogen signaling pathway, C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway, etc. The multidimensional network, quantitative estimate of the drug, and molecular docking showed that the main targets are AKT1, BCL2, and CDK6, and the key components involved are kumatakenin, astragaloside VIII, and choline. Conclusion: Kumatakenin, Astragaloside VIII, Choline and other compounds of Radix Astragali may affect colon cancer by acting on AKT1, BCL2 and other targets, thereby regulating estrogen signaling pathway, C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway and so on. Those will provide theoretical reference for future research on the material basis and mechanism of its pharmacodynamics.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45083487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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