Pub Date : 2022-10-01DOI: 10.4103/2311-8571.355594
Yong Jiang, Yaodan Chang, M. Wang, Yan-ping Sun, Yuelin Bi, Zhibin Wang, H. Kuang
Objective: The objective of this study was to study the mechanism of Radix Astragali on colon cancer by integrated pharmacology and molecular docking technique. Methods: Integrative pharmacology-based research platform of traditional Chinese medicine (TCMIP) V2.0 was used to obtain the chemical components and corresponding targets of Radix Astragali and the target information of colon cancer to create the main target network of drugs and diseases. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was carried out using Hiplot website, and the interaction network of “Traditional Chinese Medicine-component-target-pathway” was established, and molecular docking with main targets was carried out for the key components. Results: Twenty-seven chemical constituents of Radix Astragali, their 254 corresponding targets, and 44 colon cancer-related targets were obtained. Through proteins interacting, 70 nodes were obtained as core targets. GO analysis showed that it mainly acts on lipid metabolism, nuclear receptor activity, phagocytic cup, etc. KEGG pathway analysis showed that it was mainly enriched in the estrogen signaling pathway, C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway, etc. The multidimensional network, quantitative estimate of the drug, and molecular docking showed that the main targets are AKT1, BCL2, and CDK6, and the key components involved are kumatakenin, astragaloside VIII, and choline. Conclusion: Kumatakenin, Astragaloside VIII, Choline and other compounds of Radix Astragali may affect colon cancer by acting on AKT1, BCL2 and other targets, thereby regulating estrogen signaling pathway, C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway and so on. Those will provide theoretical reference for future research on the material basis and mechanism of its pharmacodynamics.
{"title":"Exploring the molecular mechanism of Radix Astragali on colon cancer based on integrated pharmacology and molecular docking technique","authors":"Yong Jiang, Yaodan Chang, M. Wang, Yan-ping Sun, Yuelin Bi, Zhibin Wang, H. Kuang","doi":"10.4103/2311-8571.355594","DOIUrl":"https://doi.org/10.4103/2311-8571.355594","url":null,"abstract":"Objective: The objective of this study was to study the mechanism of Radix Astragali on colon cancer by integrated pharmacology and molecular docking technique. Methods: Integrative pharmacology-based research platform of traditional Chinese medicine (TCMIP) V2.0 was used to obtain the chemical components and corresponding targets of Radix Astragali and the target information of colon cancer to create the main target network of drugs and diseases. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was carried out using Hiplot website, and the interaction network of “Traditional Chinese Medicine-component-target-pathway” was established, and molecular docking with main targets was carried out for the key components. Results: Twenty-seven chemical constituents of Radix Astragali, their 254 corresponding targets, and 44 colon cancer-related targets were obtained. Through proteins interacting, 70 nodes were obtained as core targets. GO analysis showed that it mainly acts on lipid metabolism, nuclear receptor activity, phagocytic cup, etc. KEGG pathway analysis showed that it was mainly enriched in the estrogen signaling pathway, C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway, etc. The multidimensional network, quantitative estimate of the drug, and molecular docking showed that the main targets are AKT1, BCL2, and CDK6, and the key components involved are kumatakenin, astragaloside VIII, and choline. Conclusion: Kumatakenin, Astragaloside VIII, Choline and other compounds of Radix Astragali may affect colon cancer by acting on AKT1, BCL2 and other targets, thereby regulating estrogen signaling pathway, C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway and so on. Those will provide theoretical reference for future research on the material basis and mechanism of its pharmacodynamics.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"502 - 508"},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45083487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/wjtcm.wjtcm_73_21
Humeyra Aslaner, H. Çalış, Çağlar Karabaşc, A. Benli
Objective: Wet cupping therapy (WCT) is one of the complementary and traditional therapies that are still must be scientifically interpreted. This study aimed to assess hemogram parameters that are subclinical inflammatory markers in patients with fibromyalgia syndrome (FMS) and observe how they were affected with WCT. Methods: The present study consisted of two groups; patient group included participants who were diagnosed with FMS and who received WCT and control group included healthy participants who received WCT within the concept of preventive medicine. Results: Neutrophil-to-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values were higher in the patient group (P = 0.029 and P = 0.003, respectively). Considering that the participants had FMS, the optimal cutoff value for PLR was ≥1.62, sensitivity was 70%, specificity was 56%, positive predictive value was 61.7%, and negative predictive value was 65.3%. Receiver operating characteristic (ROC) curve revealed a significant sensitivity and specificity (ROC area = 0.664), (confidence interval [CI]: 0.530–0.781) (P < 0.023). The optimal cutoff value for PLR was ≥146, sensitivity was 60%, specificity was 83%, positive predictive value was 78%, and negative predictive value was 67%. ROC curve revealed a statistically significant sensitivity and specificity (ROC area = 0.726), (CI: 0.59–0.83) (P < 0.001). The optimal cutoff value for platelet was ≥284,000, sensitivity was 83%, specificity was 40%, positive predictive value was 58%, and negative predictive value was 70%. ROC curve revealed a significant sensitivity and specificity (ROC area = 0.65), (CI: 0.51–0.76) (P = 0.036). Conclusion: NLR, PLR, and thrombocyte count parameters can be useful in the process of diagnosing FMS. In addition, NLR, PLR, and MPV decreased in patients who received WCT.
{"title":"Hemogram parameters in fibromyalgia and effects of wet cupping therapy on hemogram parameters","authors":"Humeyra Aslaner, H. Çalış, Çağlar Karabaşc, A. Benli","doi":"10.4103/wjtcm.wjtcm_73_21","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_73_21","url":null,"abstract":"Objective: Wet cupping therapy (WCT) is one of the complementary and traditional therapies that are still must be scientifically interpreted. This study aimed to assess hemogram parameters that are subclinical inflammatory markers in patients with fibromyalgia syndrome (FMS) and observe how they were affected with WCT. Methods: The present study consisted of two groups; patient group included participants who were diagnosed with FMS and who received WCT and control group included healthy participants who received WCT within the concept of preventive medicine. Results: Neutrophil-to-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values were higher in the patient group (P = 0.029 and P = 0.003, respectively). Considering that the participants had FMS, the optimal cutoff value for PLR was ≥1.62, sensitivity was 70%, specificity was 56%, positive predictive value was 61.7%, and negative predictive value was 65.3%. Receiver operating characteristic (ROC) curve revealed a significant sensitivity and specificity (ROC area = 0.664), (confidence interval [CI]: 0.530–0.781) (P < 0.023). The optimal cutoff value for PLR was ≥146, sensitivity was 60%, specificity was 83%, positive predictive value was 78%, and negative predictive value was 67%. ROC curve revealed a statistically significant sensitivity and specificity (ROC area = 0.726), (CI: 0.59–0.83) (P < 0.001). The optimal cutoff value for platelet was ≥284,000, sensitivity was 83%, specificity was 40%, positive predictive value was 58%, and negative predictive value was 70%. ROC curve revealed a significant sensitivity and specificity (ROC area = 0.65), (CI: 0.51–0.76) (P = 0.036). Conclusion: NLR, PLR, and thrombocyte count parameters can be useful in the process of diagnosing FMS. In addition, NLR, PLR, and MPV decreased in patients who received WCT.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"497 - 501"},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49490691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/2311-8571.351523
Songtao Liu, Senwang Zheng, Ajiao Hou, Jiaxu Zhang, Song Wang, Xuejiao Wang, Huan Yu, Liu Yang
Curcumae Longae Rhizoma (CLR) is the rhizome of Curcuma longa L. Pharmacological studies show that CLR can be used to treat cervical cancer, lung cancer, lupus nephritis, and other conditions. In this paper, we review botany, traditional application, phytochemistry, pharmacological activity, and pharmacokinetics of CLR. The literature from 1981 to date was entirely collected from online databases, such as Web of Science, Google Scholar, China Academic Journals full-text database (CNKI), Wiley, Springer, PubMed, and ScienceDirect. The data were also obtained from ancient books, theses and dissertations, and Flora Reipublicae Popularis Sinicae. There are a total of 275 compounds that have been isolated from CLR, including phenolic compounds, volatile oils, and others. The therapeutic effect of turmeric has been expanded from breaking blood and activating qi in the traditional sense to antitumor, anti-inflammatory, antioxidation, neuroprotection, antibacterial, hypolipidemic effects, and other benefits. However, the active ingredients and mechanisms of action related to relieving disease remain ill defined, which requires more in-depth research and verification at a clinical level.
姜黄（CLR）是姜黄的根状茎。药理研究表明，CLR可用于治疗宫颈癌症、癌症、狼疮性肾炎等疾病。本文综述了CLR的植物学、传统应用、植物化学、药理活性和药代动力学。从1981年至今的文献完全收集自在线数据库，如Web of Science、Google Scholar、中国学术期刊全文数据库（CNKI）、Wiley、Springer、PubMed和ScienceDirect。这些数据也来自古籍、论文和学位论文以及《大众植物志》。共有275种化合物从CLR中分离出来，包括酚类化合物、挥发油和其他化合物。姜黄的治疗作用已从传统意义上的活血益气扩展到抗肿瘤、抗炎、抗氧化、神经保护、抗菌、降血脂等功效。然而，与缓解疾病相关的活性成分和作用机制仍不明确，需要在临床层面进行更深入的研究和验证。
{"title":"A review: The phytochemistry, pharmacology, and pharmacokinetics of Curcumae Longae Rhizoma (Turmeric)","authors":"Songtao Liu, Senwang Zheng, Ajiao Hou, Jiaxu Zhang, Song Wang, Xuejiao Wang, Huan Yu, Liu Yang","doi":"10.4103/2311-8571.351523","DOIUrl":"https://doi.org/10.4103/2311-8571.351523","url":null,"abstract":"Curcumae Longae Rhizoma (CLR) is the rhizome of Curcuma longa L. Pharmacological studies show that CLR can be used to treat cervical cancer, lung cancer, lupus nephritis, and other conditions. In this paper, we review botany, traditional application, phytochemistry, pharmacological activity, and pharmacokinetics of CLR. The literature from 1981 to date was entirely collected from online databases, such as Web of Science, Google Scholar, China Academic Journals full-text database (CNKI), Wiley, Springer, PubMed, and ScienceDirect. The data were also obtained from ancient books, theses and dissertations, and Flora Reipublicae Popularis Sinicae. There are a total of 275 compounds that have been isolated from CLR, including phenolic compounds, volatile oils, and others. The therapeutic effect of turmeric has been expanded from breaking blood and activating qi in the traditional sense to antitumor, anti-inflammatory, antioxidation, neuroprotection, antibacterial, hypolipidemic effects, and other benefits. However, the active ingredients and mechanisms of action related to relieving disease remain ill defined, which requires more in-depth research and verification at a clinical level.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"463 - 490"},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43774751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/2311-8571.351509
Siqi Zhang, Dong Lin, Lili Lin, Shi Qi, Meng Gong, Shi Li, Jie Zhang
Objective: The therapeutic effect of acupuncture is often evaluated based on the experience and judgment of acupuncturists and the subjective feelings of patients. Thus, we investigated the suitability of goal attainment scaling (GAS), an objective outcome measurements, to evaluate the responsiveness of children with intellectual disability to acupuncture therapy. Methods: This is an assessor-blinded, single-group cohort study that included 17 children with intellectual disabilities. The therapeutic effect of acupuncture was assessed by the T scores of GAS at four time points during the 3-month treatment. The responsiveness of GAS to acupuncture therapy was measured using the standardized response mean (SRM). Results: Compared with control, the 4-, 8-, and 12-week scores improved significantly after treatment (P < 0.01, P ≤ 0.001, P ≤ 0.001), with significant differences between each month (P < 0.01, P ≤ 0.001, P ≤ 0.001). Furthermore, all periods assessed GAS (to measure the therapeutic effect of acupuncture) showed marked responsiveness (SRMs >0.8). Conclusion: GAS is responsive in evaluating individual changes in the acupuncture treatment of children with intellectual disabilities. It is a feasible tool to match both the needs of children with intellectual disabilities and the clinical characteristics of acupuncture.
{"title":"The use of goal attainment scaling in the acupuncture of children with intellectual disability","authors":"Siqi Zhang, Dong Lin, Lili Lin, Shi Qi, Meng Gong, Shi Li, Jie Zhang","doi":"10.4103/2311-8571.351509","DOIUrl":"https://doi.org/10.4103/2311-8571.351509","url":null,"abstract":"Objective: The therapeutic effect of acupuncture is often evaluated based on the experience and judgment of acupuncturists and the subjective feelings of patients. Thus, we investigated the suitability of goal attainment scaling (GAS), an objective outcome measurements, to evaluate the responsiveness of children with intellectual disability to acupuncture therapy. Methods: This is an assessor-blinded, single-group cohort study that included 17 children with intellectual disabilities. The therapeutic effect of acupuncture was assessed by the T scores of GAS at four time points during the 3-month treatment. The responsiveness of GAS to acupuncture therapy was measured using the standardized response mean (SRM). Results: Compared with control, the 4-, 8-, and 12-week scores improved significantly after treatment (P < 0.01, P ≤ 0.001, P ≤ 0.001), with significant differences between each month (P < 0.01, P ≤ 0.001, P ≤ 0.001). Furthermore, all periods assessed GAS (to measure the therapeutic effect of acupuncture) showed marked responsiveness (SRMs >0.8). Conclusion: GAS is responsive in evaluating individual changes in the acupuncture treatment of children with intellectual disabilities. It is a feasible tool to match both the needs of children with intellectual disabilities and the clinical characteristics of acupuncture.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"522 - 529"},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48025957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The objective of this study is to explore the treatment and compatibility principles of Traditional Chinese Medicine. Materials and Methods: Syndrome differentiation is used to identify the etiology, nature, and location of a disease and the relationship between the healthy Qi and pathogenic factors by analyzing and synthesizing the four diagnostics data. The theory of treatment is to determine the principle and methods of treatment according to the results of syndrome differentiation and implement them as a specific prescription. This paper bears witness to the principle universality by analysis of the articles of the Banxia Xiexin Decoction, and it equally has analogical prescriptions in Treatise on Febrile Diseases. Results: The treatment and compatibility principles of Traditional Chinese Medicine are the same, that is, rectifying the deviation on three dimensions, strengthening the healthy Qi, and eliminating pathogenic factors in the light of its general trend. Conclusion: The treatment and compatibility principles of Traditional Chinese Medicine are the same, The treatment and compatibility principles provide a new thinking for clinical treatment.
{"title":"New analysis of banxia xiexin decoction and its similar prescriptions in Treatise on Febrile Diseases to explore the universality of the treatment and compatibility principle","authors":"Ren Wei, Zhengrong Li, Ruidi Cao, Jian-Bin Zeng, Jianxiong Shen, Qiulan Pei, Qilin Liang","doi":"10.4103/2311-8571.343651","DOIUrl":"https://doi.org/10.4103/2311-8571.343651","url":null,"abstract":"Objective: The objective of this study is to explore the treatment and compatibility principles of Traditional Chinese Medicine. Materials and Methods: Syndrome differentiation is used to identify the etiology, nature, and location of a disease and the relationship between the healthy Qi and pathogenic factors by analyzing and synthesizing the four diagnostics data. The theory of treatment is to determine the principle and methods of treatment according to the results of syndrome differentiation and implement them as a specific prescription. This paper bears witness to the principle universality by analysis of the articles of the Banxia Xiexin Decoction, and it equally has analogical prescriptions in Treatise on Febrile Diseases. Results: The treatment and compatibility principles of Traditional Chinese Medicine are the same, that is, rectifying the deviation on three dimensions, strengthening the healthy Qi, and eliminating pathogenic factors in the light of its general trend. Conclusion: The treatment and compatibility principles of Traditional Chinese Medicine are the same, The treatment and compatibility principles provide a new thinking for clinical treatment.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"509 - 513"},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44025531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/2311-8571.353119
Xingzhi Wu, Lixin Xie, Lina Liang
{"title":"International Clinical Practice Guideline of Chinese Medicine-Age-related Macular Degeneration","authors":"Xingzhi Wu, Lixin Xie, Lina Liang","doi":"10.4103/2311-8571.353119","DOIUrl":"https://doi.org/10.4103/2311-8571.353119","url":null,"abstract":"","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"556 - 564"},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43378635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to identify the potential metabolic biomarkers of the Badagan constitution (BC) in Mongolian medicine. Serum samples from the participants with BCs (n = 32) and aggregative constitutions (n = 30) were analyzed by using ultrahigh-performance liquid chromatography/mass spectrometry. Meanwhile, principal component analysis and orthogonal partial least squares discriminant analysis were used to characterize the endogenous metabolites and potential biomarkers, respectively. Fifteen of the 18 biomarkers in six metabolic pathways were significantly upregulated, including phosphatidylserine, sphingolipids, tryptophan, riboflavin and glutathione, and three biomarkers were significantly downregulated, including lysophosphatidylcholine (LysoPC) (18:1), LysoPC (16:1), and lysophosphatidylethanolamine (LysoPE) (22:2). This study also implied that sphingolipid metabolism, glycerophospholipid metabolism, and tryptophan metabolism played important roles in the BC. Therefore, metabolomics may improve the diagnostic efficacy of the BC in terms of the accuracy and comprehensiveness of a diagnosis based on this constitution. This result further reveals the mechanism of the constitution type in Mongolian medicine and provides a reference for the treatment of related diseases.
{"title":"Metabolic characterization of the Badagan constitution in mongolian medicine by ultrahigh-performance liquid chromatography/quadrupole time-of-flight mass spectrometry/MS","authors":"Xiao-hua Bao, Lina Bao, Chun Xiang, Siqin Gerile, Saihan Qiqige, Yuheng Xie","doi":"10.4103/2311-8571.351507","DOIUrl":"https://doi.org/10.4103/2311-8571.351507","url":null,"abstract":"This study aimed to identify the potential metabolic biomarkers of the Badagan constitution (BC) in Mongolian medicine. Serum samples from the participants with BCs (n = 32) and aggregative constitutions (n = 30) were analyzed by using ultrahigh-performance liquid chromatography/mass spectrometry. Meanwhile, principal component analysis and orthogonal partial least squares discriminant analysis were used to characterize the endogenous metabolites and potential biomarkers, respectively. Fifteen of the 18 biomarkers in six metabolic pathways were significantly upregulated, including phosphatidylserine, sphingolipids, tryptophan, riboflavin and glutathione, and three biomarkers were significantly downregulated, including lysophosphatidylcholine (LysoPC) (18:1), LysoPC (16:1), and lysophosphatidylethanolamine (LysoPE) (22:2). This study also implied that sphingolipid metabolism, glycerophospholipid metabolism, and tryptophan metabolism played important roles in the BC. Therefore, metabolomics may improve the diagnostic efficacy of the BC in terms of the accuracy and comprehensiveness of a diagnosis based on this constitution. This result further reveals the mechanism of the constitution type in Mongolian medicine and provides a reference for the treatment of related diseases.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"539 - 547"},"PeriodicalIF":4.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43980622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/2311-8571.352471
Thi Tam Pham, Thi Cuc Le, V. Tran, Van Thanh Nguyen
Traditional Vietnamese Medicine has its own development based on the local endemic herbs, but it also inherits from Traditional Chinese Medicine using Chinese herbal medicines. Throughout the history of cultural exchange between two countries, the adoption of Chinese Danggui, Angelica sinensis (Oliv.) Diels., has been made by Vietnamese traditional medicine practitioners for a long time. However, the acclimatization has never been successful. Japanese Danggui, or Angelica acutiloba Kitagawa, is recently being acclimatized and cultivated in several Vietnamese regions. Despite the huge climate change between the two countries, the herb adapted exquisitely well to the humid tropical climate. However, so far, there are no studies that have evaluated the effect of acclimatization on the overall quality of this medicinal herb. The aim of our study is screening secondary metabolites of this acclimatized herb for new natural compound(s), if any. The analysis of flavonoid fraction from this herb led to the identification of two known compounds which previously have not been isolated from this species elsewhere. This detection showed that the herb has reacted to the new environment.
{"title":"Isolation and identification of two flavonoid compounds from acclimatized Angelica acutiloba kitagawa growing in Vietnam","authors":"Thi Tam Pham, Thi Cuc Le, V. Tran, Van Thanh Nguyen","doi":"10.4103/2311-8571.352471","DOIUrl":"https://doi.org/10.4103/2311-8571.352471","url":null,"abstract":"Traditional Vietnamese Medicine has its own development based on the local endemic herbs, but it also inherits from Traditional Chinese Medicine using Chinese herbal medicines. Throughout the history of cultural exchange between two countries, the adoption of Chinese Danggui, Angelica sinensis (Oliv.) Diels., has been made by Vietnamese traditional medicine practitioners for a long time. However, the acclimatization has never been successful. Japanese Danggui, or Angelica acutiloba Kitagawa, is recently being acclimatized and cultivated in several Vietnamese regions. Despite the huge climate change between the two countries, the herb adapted exquisitely well to the humid tropical climate. However, so far, there are no studies that have evaluated the effect of acclimatization on the overall quality of this medicinal herb. The aim of our study is screening secondary metabolites of this acclimatized herb for new natural compound(s), if any. The analysis of flavonoid fraction from this herb led to the identification of two known compounds which previously have not been isolated from this species elsewhere. This detection showed that the herb has reacted to the new environment.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"413 - 416"},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44408577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/wjtcm.wjtcm_16_22
Yi-wen Zhang, Feng Nie, Xiao-yu Zheng, Shu-juan Zhao
L-tyrosine, an aromatic amino acid, is an important upstream precursor for the synthesis of a series of valuable natural products such as flavonoids and phenolic acids. In recent years, regulation of the L-tyrosine metabolic pathway has been devoted to enhancing the production of L-tyrosine and the derived bioactive compounds in microorganisms, usually by increasing the supply of precursors, blocking competitive routes, and modulating the transport system. Here, we reviewed the strategies to promote L-tyrosine production in microbial hosts and the common strategies to produce bioactive compounds in engineered Escherichia coli and Saccharomyces cerevisiae to better understand and utilize the L-tyrosine metabolic pathway for microbial overproduction of diverse valuable aromatic compounds in the future.
l -酪氨酸是一种芳香氨基酸，是合成黄酮和酚酸等一系列有价值的天然产物的重要上游前体。近年来，对l -酪氨酸代谢途径的调控致力于提高微生物中l -酪氨酸及其衍生生物活性化合物的生产，通常通过增加前体的供应，阻断竞争途径和调节运输系统。本文综述了微生物宿主体内促进l -酪氨酸生成的策略，以及在工程大肠杆菌和酿酒酵母中产生生物活性化合物的常见策略，以期更好地了解和利用l -酪氨酸代谢途径，促进微生物过量生产多种有价值的芳香族化合物。
{"title":"L-tyrosine metabolic pathway in microorganisms and its application in the biosynthesis of plant-derived natural products","authors":"Yi-wen Zhang, Feng Nie, Xiao-yu Zheng, Shu-juan Zhao","doi":"10.4103/wjtcm.wjtcm_16_22","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_16_22","url":null,"abstract":"L-tyrosine, an aromatic amino acid, is an important upstream precursor for the synthesis of a series of valuable natural products such as flavonoids and phenolic acids. In recent years, regulation of the L-tyrosine metabolic pathway has been devoted to enhancing the production of L-tyrosine and the derived bioactive compounds in microorganisms, usually by increasing the supply of precursors, blocking competitive routes, and modulating the transport system. Here, we reviewed the strategies to promote L-tyrosine production in microbial hosts and the common strategies to produce bioactive compounds in engineered Escherichia coli and Saccharomyces cerevisiae to better understand and utilize the L-tyrosine metabolic pathway for microbial overproduction of diverse valuable aromatic compounds in the future.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"8 1","pages":"386 - 394"},"PeriodicalIF":4.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46526206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/2311-8571.333712
Velika Yovitania, Qin-hui Fu, J. Pei, Hua Zhou
Acupuncture has been used to treat ischemic stroke, and mounting evidence demonstrates the neuroprotective and autophagy-mediated actions of electroacupuncture (EA). This review summarizes the evidence that EA affects different stages of autophagy, its neuroprotective action, and effects of different acupoints in treating ischemic stroke. Systematic searches were conducted on English and Chinese databases (MEDLINE, Elsevier, ScienceDirect, Cochrane Library, and China National Knowledge Infrastructure). Studies published up until February 2021 were considered for inclusion, and a final of fifty articles were included in this review. There is evidence that acupuncture promotes neuroprotection by modulating autophagy, and the treatment effectiveness is related to the acupoint selection and timing of treatment administration.
针刺已被用于治疗缺血性脑卒中，越来越多的证据表明电针(EA)具有神经保护和自噬介导的作用。本文综述了脑电对脑自噬不同阶段的影响、其神经保护作用以及不同穴位治疗缺血性脑卒中的作用。系统检索了中英文数据库(MEDLINE, Elsevier, ScienceDirect, Cochrane Library, China National Knowledge Infrastructure)。在2021年2月之前发表的研究被纳入考虑，最终50篇文章被纳入本综述。有证据表明，针灸通过调节自噬来促进神经保护，其治疗效果与穴位选择和给药时间有关。
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