The pharmacodynamics of adrenaline were investigated with respect to the adrenergic regulation of the contractility, of the pumping function and of the systolic function of the heart, aiming at the examination of age particularities. The results show that the positively effect of adrenaline becomes less with increasing age. The arrhythmogenic effect of the preparation is described, just as its effect on blood pressure regulation. The results are discussed in detail.
This report is based on a 9-year thorough epidemiological study of the lethality of atherosclerosis among people older than 45 years in Bulgaria.
Iopanoic acid, an iodine containing contrast medium was administered orally to healthy subjects aged 20-40 years (n = 9) and 70-90 years (n = 10) and also to sick aged persons (aged 70-90 years, n = 10). Thyroid hormones: T4, T3, rT3, T3-uptake and thyrotropin (TSH) serum levels were estimated before and three and seven days after iopanoic acid. No significant TSH increase could be seen in the old-age groups: the T4 increases were similar in all three groups as well as the slight T3 decreases; the serum rT3 increase was significantly greater in the aged healthy and the sick subjects. The data suggests that in aged humans serum T4 elevation after iopanoic acid is a result of delayed thyroxine metabolism and not secondary to TSH release. Iopanoic acid administration is, aside from the TRH test, another model to demonstrate in geriatric patients thyrotroph hypofunction via the altered effect of inhibition of T4 deiodination on TSH release.
The hemodynamic response to postural stress (75 degrees foot-down tilt) was observed in 14 elderly normotensives (age range 61-92 years) and 15 younger controls (20-30 years). Both the immediate heart-rate response and the increase of the diastolic blood pressure was reduced in elderly individuals, although they didn't suffer from postural hypotension. The suppression of heart-rate oscillation after tilting could be a possible sign of aging alterations. It is concluded, that drug-dependent "normal" blood pressure levels in elderly patient decrease the orthostatic tolerance if the baroreflex is impaired.
Pneumonia in old age often leads to death even under hospital conditions. This results in the necessity of an early and effective therapy. In a retrospective analysis differential-therapeutic aspects showed that the disease can be influenced by means of pharmacotherapy in different ways. The results indicate that penicillin and semi-synthetic derivatives are more efficacious than chloramphenicol and sulphonamides. Further specific studies of the efficacy of the drugs to be applied for older patients should be intended.
Using an one-year-analysis depressive people beyond the age of 60 are analysed during a catamnesis-project considering clinical dates (under psychopathological, psychosocial and therapeutical emphasis) in which have directions for a change of the proportion of sick people to healthy people and the change of the shape of age-depressive syndromes deduced.
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：