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Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer 前列腺癌 12 次碳离子放疗后剂量-体积参数与直肠出血之间的相关性
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-28 DOI: 10.4329/wjr.v16.i7.256
Takashi Ono, Hiraku Sato, Y. Miyasaka, Y. Hagiwara, N. Yano, H. Akamatsu, Mayumi Harada, Mayumi Ichikawa
BACKGROUND Carbon ion radiotherapy (CIRT) is currently used to treat prostate cancer. Rectal bleeding is a major cause of toxicity even with CIRT. However, to date, a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been shown. Similarly, the clinical risk factors for rectal bleeding were absent after 12 fractions of CIRT. AIM To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate cancer. METHODS Among 259 patients who received 51.6 Gy [relative biological effectiveness (RBE)], in 12 fractions of CIRT, 15 had grade 1 (5.8%) and nine had grade 2 rectal bleeding (3.5%). The dose-volume parameters included the volume (cc) of the rectum irradiated with at least x Gy (RBE) (Vx) and the minimum dose in the most irradiated x cc normal rectal volume (Dx). RESULTS The mean values of D6cc, D2cc, V10 Gy (RBE), V20 Gy (RBE), V30 Gy (RBE), and V40 Gy (RBE) were significantly higher in the patients with rectal bleeding than in those without. The cutoff values were D6cc = 34.34 Gy (RBE), D2cc = 46.46 Gy (RBE), V10 Gy (RBE) = 9.85 cc, V20 Gy (RBE) = 7.00 cc, V30 Gy (RBE) = 6.91 cc, and V40 Gy (RBE) = 4.26 cc. The D2cc, V10 Gy (RBE), and V20 Gy (RBE) cutoff values were significant predictors of grade 2 rectal bleeding. CONCLUSION The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.
背景 碳离子放射疗法(CIRT)目前用于治疗前列腺癌。即使是 CIRT,直肠出血也是造成毒性的一个主要原因。然而,迄今为止,尚未发现前列腺癌 12 次 CIRT 的剂量和体积参数与直肠出血之间存在相关性。同样,在 12 次 CIRT 治疗后,也没有发现直肠出血的临床风险因素。目的 确定前列腺癌 12 次 CIRT 治疗中直肠出血的风险因素。方法 在 259 例接受了 51.6 Gy [相对生物效应 (RBE)] 12 次 CIRT 的患者中,15 例出现 1 级直肠出血(5.8%),9 例出现 2 级直肠出血(3.5%)。剂量-体积参数包括至少照射 x Gy 的直肠体积(cc)(RBE)(Vx)和照射量最大的 x cc 正常直肠体积的最小剂量(Dx)。结果 直肠出血患者的 D6cc、D2cc、V10 Gy(RBE)、V20 Gy(RBE)、V30 Gy(RBE)和 V40 Gy(RBE)的平均值明显高于未出血患者。临界值为 D6cc = 34.34 Gy(RBE)、D2cc = 46.46 Gy(RBE)、V10 Gy(RBE)= 9.85 cc、V20 Gy(RBE)= 7.00 cc、V30 Gy(RBE)= 6.91 cc 和 V40 Gy(RBE)= 4.26 cc。D2cc、V10 Gy (RBE) 和 V20 Gy (RBE) 临界值可显著预测 2 级直肠出血。结论 上述剂量-体积参数可作为前列腺癌 12 次 CIRT 治疗后预防直肠出血的指南。
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引用次数: 0
Ultrasomics in liver cancer: Developing a radiomics model for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma using contrast-enhanced ultrasound 肝癌超声组学:利用造影剂增强超声建立放射组学模型,以区分肝内胆管癌和肝细胞癌
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-28 DOI: 10.4329/wjr.v16.i7.247
Li-Ya Su, Ming Xu, Yanlin Chen, Man-Xia Lin, Xiaoyan Xie
BACKGROUND Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) represent the predominant histological types of primary liver cancer, comprising over 99% of cases. Given their differing biological behaviors, prognoses, and treatment strategies, accurately differentiating between HCC and ICC is crucial for effective clinical management. Radiomics, an emerging image processing technology, can automatically extract various quantitative image features that may elude the human eye. Reports on the application of ultrasound (US)-based radiomics methods in distinguishing HCC from ICC are limited. AIM To develop and validate an ultrasomics model to accurately differentiate between HCC and ICC. METHODS In our retrospective study, we included a total of 280 patients who were diagnosed with ICC (n = 140) and HCC (n = 140) between 1999 and 2019. These patients were divided into training (n = 224) and testing (n = 56) groups for analysis. US images and relevant clinical characteristics were collected. We utilized the XGBoost method to extract and select radiomics features and further employed a random forest algorithm to establish ultrasomics models. We compared the diagnostic performances of these ultrasomics models with that of radiologists. RESULTS Four distinct ultrasomics models were constructed, with the number of selected features varying between models: 13 features for the US model; 15 for the contrast-enhanced ultrasound (CEUS) model; 13 for the combined US + CEUS model; and 21 for the US + CEUS + clinical data model. The US + CEUS + clinical data model yielded the highest area under the receiver operating characteristic curve (AUC) among all models, achieving an AUC of 0.973 in the validation cohort and 0.971 in the test cohort. This performance exceeded even the most experienced radiologist (AUC = 0.964). The AUC for the US + CEUS model (training cohort AUC = 0.964, test cohort AUC = 0.955) was significantly higher than that of the US model alone (training cohort AUC = 0.822, test cohort AUC = 0.816). This finding underscored the significant benefit of incorporating CEUS information in accurately distinguishing ICC from HCC. CONCLUSION We developed a radiomics diagnostic model based on CEUS images capable of quickly distinguishing HCC from ICC, which outperformed experienced radiologists.
背景 肝细胞癌(HCC)和肝内胆管癌(ICC)是原发性肝癌的主要组织学类型,占 99% 以上的病例。鉴于它们不同的生物学行为、预后和治疗策略,准确区分 HCC 和 ICC 对于有效的临床管理至关重要。放射组学是一种新兴的图像处理技术,可自动提取人眼无法识别的各种定量图像特征。基于超声波(US)的放射组学方法在区分 HCC 和 ICC 方面的应用报道还很有限。目的 开发并验证一种超声组学模型,以准确区分 HCC 和 ICC。方法 在我们的回顾性研究中,我们纳入了 1999 年至 2019 年期间确诊为 ICC(n = 140)和 HCC(n = 140)的 280 例患者。这些患者被分为训练组(n = 224)和测试组(n = 56)进行分析。我们收集了 US 图像和相关临床特征。我们利用 XGBoost 方法提取和选择放射组学特征,并进一步采用随机森林算法建立超声组学模型。我们将这些超声组学模型的诊断性能与放射科医生的诊断性能进行了比较。结果 构建了四个不同的超声组学模型,不同模型所选特征的数量各不相同:US 模型有 13 个特征;对比增强超声 (CEUS) 模型有 15 个特征;US + CEUS 组合模型有 13 个特征;US + CEUS + 临床数据模型有 21 个特征。在所有模型中,US+CEUS+临床数据模型的接收者操作特征曲线下面积(AUC)最高,在验证队列中的AUC为0.973,在测试队列中的AUC为0.971。这一成绩甚至超过了最有经验的放射科医生(AUC = 0.964)。US + CEUS 模型的 AUC(培训队列 AUC = 0.964,测试队列 AUC = 0.955)明显高于单独的 US 模型(培训队列 AUC = 0.822,测试队列 AUC = 0.816)。这一发现强调了结合 CEUS 信息在准确区分 ICC 和 HCC 方面的重大优势。结论 我们开发了一种基于 CEUS 图像的放射组学诊断模型,能够快速区分 HCC 和 ICC,其效果优于经验丰富的放射科医生。
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引用次数: 0
Incidence of exclusive extrapelvic skeletal metastasis in prostate carcinoma on bone scintigraphy 骨闪烁扫描显示前列腺癌骨盆外骨骼转移的发生率
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-28 DOI: 10.4329/wjr.v16.i7.265
Parneet Singh, K. Agrawal, Ashique Rahman, T. Singhal, G. K. Parida, G. Gnanasegaran
BACKGROUND Bone is one of the common sites of metastasis from prostate carcinoma. Bone scintigraphy (BS) is one of the most sensitive imaging modalities currently used for bone metastatic work-up. Skeletal metastasis in prostate carcinoma commonly involves pelvic bones but rarely involves extrapelvic-extraspinal sites. AIM To retrospectively analyze the BS data to determine the pattern of skeletal metastases in the prostate carcinoma. METHODS This retrospective observational study involves patients with biopsy-proven prostate carcinoma referred for BS for staging assessment. Patients with abnormal BS were evaluated for the pattern of skeletal involvement and data were presented in descriptive format in the form of percentages. RESULTS A total of 150 patients with biopsy-proven prostate cancer who were referred for staging were included in the study. Thirteen of 150 patients (8.67%) had no abnormal uptake on planar images, ruling out metastatic disease. Twenty-four patients (16%) had heterogeneous uptake in the spine with distribution characteristic of degenerative disease and no scan pattern of metastatic disease. Thirty patients (20%) had multifocal uptake involving both pelvic and extra pelvic bones on planar images typical for skeletal metastasis and were considered metastatic. Eighty-three out of 150 patients (55.3%) had increased tracer uptake, which was indeterminate, thus, single photon emission computed tomography-computed tomography (SPECT-CT) was acquired, which showed 51 with metastatic disease, 31 benign lesions, and one indeterminate finding. Seven of 150 patients had exclusive pelvic bone uptake, which was found to be metastatic in 4/7 patients in SPECT-CT. Fifty six out of 150 patients showed exclusive extrapelvic tracer uptake, of which only 3 had vertebral metastatic disease. None of the patients with increased uptake exclusively in the extrapelvic-extraspinal location was metastatic. CONCLUSION The incidence of exclusive extrapelvic skeletal metastatic disease in prostate carcinoma is 2% (excluding one patient with indeterminate findings). Further, none of the patients in the current study had exclusive extrapelvic-extraspinal metastasis. Thus, exclusive extrapelvic-extraspinal focal abnormality on planar BS carries a very low probability of metastatic disease and hence, further imaging or SPECT-CT can be safely avoided in such cases.
背景 骨是前列腺癌转移的常见部位之一。骨闪烁成像(BS)是目前用于骨转移检查的最灵敏的成像方式之一。前列腺癌的骨骼转移通常涉及盆骨,但很少涉及骨盆外部位。目的 回顾性分析 BS 数据,确定前列腺癌骨骼转移的模式。方法 此项回顾性观察研究涉及经活检证实的前列腺癌患者,他们被转诊至 BS 进行分期评估。对 BS 异常的患者进行骨骼受累模式评估,并以描述性的百分比形式提供数据。结果 本研究共纳入 150 名经活检证实的前列腺癌患者,这些患者被转诊进行分期。150 名患者中有 13 名(8.67%)在平面图像上没有异常摄取,排除了转移性疾病。24名患者(16%)的脊柱出现异常摄取,其分布具有退行性疾病的特征,但没有转移性疾病的扫描模式。30名患者(20%)在平面图像上有多灶摄取,涉及骨盆和骨盆外骨骼,是典型的骨骼转移,被认为是转移性疾病。150 例患者中有 83 例(55.3%)示踪剂摄取增加,无法确定,因此进行了单光子发射计算机断层扫描(SPECT-CT),结果显示 51 例有转移性疾病,31 例为良性病变,1 例为不确定结果。150 例患者中有 7 例骨盆骨吸收,SPECT-CT 发现其中 4/7 例为转移性骨吸收。150 名患者中有 56 人出现骨盆外示踪剂摄取,其中只有 3 人患有椎体转移性疾病。在骨盆外-椎体外位置摄取增加的患者中,没有一人发生转移。结论 前列腺癌骨盆外骨骼转移性疾病的发生率为 2%(不包括一名结果不确定的患者)。此外,本研究中没有一名患者出现骨盆外-椎体外转移。因此,在平面 BS 上出现骨盆外-骶骨外局灶异常的转移性疾病的概率非常低,因此在这种情况下可以安全地避免进一步的成像或 SPECT-CT。
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引用次数: 0
Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography. 使用计算机断层扫描比较胰腺实性假乳头状瘤和伴有囊性改变的胰腺导管腺癌。
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-28 DOI: 10.4329/wjr.v16.i6.211
Shuai Ren, Li-Chao Qian, Xiao-Jing Lv, Ying-Ying Cao, Marcus J Daniels, Zhong-Qiu Wang, Li-Na Song, Ying Tian

Background: Solid pseudopapillary neoplasms of the pancreas (SPN) share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes (PDAC with cystic changes), which may result in unnecessary surgery.

Aim: To investigate the value of computed tomography (CT) in differentiation of SPN from PDAC with cystic changes.

Methods: This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes, confirmed through pathological diagnosis. Quantitative and qualitative analysis was performed, including assessment of age, sex, tumor size, shape, margin, density, enhancement pattern, CT values of tumors, CT contrast enhancement ratios, "floating cloud sign," calcification, main pancreatic duct dilatation, pancreatic atrophy, and peripancreatic invasion or distal metastasis. Multivariate logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes, and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their combination.

Results: When compared to PDAC with cystic changes, SPN had a lower age (32 years vs 64 years, P < 0.05) and a slightly larger size (5.41 cm vs 3.90 cm, P < 0.05). SPN had a higher frequency of "floating cloud sign" and peripancreatic invasion or distal metastasis than PDAC with cystic changes (both P < 0.05). No significant difference was found with respect to sex, tumor location, shape, margin, density, main pancreatic duct dilatation, calcification, pancreatic atrophy, enhancement pattern, CT values of tumors, or CT contrast enhancement ratios between the two groups (all P > 0.05). The area under the receiver operating characteristic curve of the combination was 0.833 (95% confidence interval: 0.708-0.957) with 78.6% sensitivity, 81.3% specificity, and 80.4% accuracy in differentiation of SPN from PDAC with cystic changes.

Conclusion: A larger tumor size, "floating cloud sign," and peripancreatic invasion or distal metastasis are useful CT imaging features that are more common in SPN and may help discriminate SPN from PDAC with cystic changes.

背景:胰腺实性假乳头状瘤(SPN目的:探讨计算机断层扫描(CT)在鉴别胰腺实性假乳头状瘤(SPN)和伴囊性改变的胰腺导管腺癌(PDAC)方面的价值:本研究回顾性分析了32例经病理诊断确诊为SPN的患者和14例经病理诊断确诊为有囊性变的PDAC患者的临床和影像学结果。研究进行了定量和定性分析,包括评估年龄、性别、肿瘤大小、形状、边缘、密度、增强模式、肿瘤的CT值、CT对比增强比、"浮云征"、钙化、主胰管扩张、胰腺萎缩、胰周侵犯或远端转移。采用多变量逻辑回归分析确定了区分SPN和伴囊性变的PDAC的相关特征,并绘制了接收器操作特征曲线,以评估各变量及其组合的诊断性能:与伴囊性变的PDAC相比,SPN的年龄较小(32岁对64岁,P<0.05),体积稍大(5.41厘米对3.90厘米,P<0.05)。与出现囊性改变的PDAC相比,SPN出现 "浮云征 "和胰周侵犯或远端转移的频率更高(均为P < 0.05)。两组患者在性别、肿瘤位置、形状、边缘、密度、主胰管扩张、钙化、胰腺萎缩、增强模式、肿瘤 CT 值或 CT 对比增强比等方面均无明显差异(均 P > 0.05)。该组合的接收器操作特征曲线下面积为 0.833(95% 置信区间:0.708-0.957),在鉴别 SPN 和 PDAC 伴囊性变方面的敏感性为 78.6%,特异性为 81.3%,准确性为 80.4%:结论:肿瘤体积较大、"浮云征"、胰周侵犯或远端转移是有用的CT成像特征,这些特征在SPN中更为常见,可能有助于鉴别SPN和伴囊性变的PDAC。
{"title":"Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography.","authors":"Shuai Ren, Li-Chao Qian, Xiao-Jing Lv, Ying-Ying Cao, Marcus J Daniels, Zhong-Qiu Wang, Li-Na Song, Ying Tian","doi":"10.4329/wjr.v16.i6.211","DOIUrl":"10.4329/wjr.v16.i6.211","url":null,"abstract":"<p><strong>Background: </strong>Solid pseudopapillary neoplasms of the pancreas (SPN) share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes (PDAC with cystic changes), which may result in unnecessary surgery.</p><p><strong>Aim: </strong>To investigate the value of computed tomography (CT) in differentiation of SPN from PDAC with cystic changes.</p><p><strong>Methods: </strong>This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes, confirmed through pathological diagnosis. Quantitative and qualitative analysis was performed, including assessment of age, sex, tumor size, shape, margin, density, enhancement pattern, CT values of tumors, CT contrast enhancement ratios, \"floating cloud sign,\" calcification, main pancreatic duct dilatation, pancreatic atrophy, and peripancreatic invasion or distal metastasis. Multivariate logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes, and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their combination.</p><p><strong>Results: </strong>When compared to PDAC with cystic changes, SPN had a lower age (32 years <i>vs</i> 64 years, <i>P</i> < 0.05) and a slightly larger size (5.41 cm <i>vs</i> 3.90 cm, <i>P</i> < 0.05). SPN had a higher frequency of \"floating cloud sign\" and peripancreatic invasion or distal metastasis than PDAC with cystic changes (both <i>P</i> < 0.05). No significant difference was found with respect to sex, tumor location, shape, margin, density, main pancreatic duct dilatation, calcification, pancreatic atrophy, enhancement pattern, CT values of tumors, or CT contrast enhancement ratios between the two groups (all <i>P ></i> 0.05). The area under the receiver operating characteristic curve of the combination was 0.833 (95% confidence interval: 0.708-0.957) with 78.6% sensitivity, 81.3% specificity, and 80.4% accuracy in differentiation of SPN from PDAC with cystic changes.</p><p><strong>Conclusion: </strong>A larger tumor size, \"floating cloud sign,\" and peripancreatic invasion or distal metastasis are useful CT imaging features that are more common in SPN and may help discriminate SPN from PDAC with cystic changes.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal resistive index measurements by ultrasound in patients with liver cirrhosis: Magnitude and associations with renal dysfunction. 通过超声波测量肝硬化患者的肾阻力指数:肝硬化患者的肾阻力指数测量:幅度及与肾功能障碍的关系。
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-28 DOI: 10.4329/wjr.v16.i6.221
Himanshu Surya, Ramesh Kumar, Rajeev Nayan Priyadarshi, Sabbu Surya Prakash, Sudhir Kumar

Background: The hemodynamic alterations seen in liver cirrhosis lead to renal vasoconstriction, ultimately causing acute kidney injury (AKI). The renal resistive index (RRI) is the most common Doppler ultrasound variable for measuring intrarenal vascular resistance.

Aim: To evaluate the association of the RRI with AKI in patients with liver cirrhosis and to identify risk factors for high RRI.

Methods: This was a prospective observational study, where RRI was measured using Doppler ultrasound in 200 consecutive hospitalized patients with cirrhosis. The association of RRI with AKI was studied. The receiver operating characteristic (ROC) curve analysis was utilized to determine discriminatory cut-offs of RRI for various AKI phenotypes. Multivariate analysis was conducted to determine the predictors of high RRI.

Results: The mean patient age was 49.08 ± 11.68 years, with the majority (79.5%) being male; the predominant etiology of cirrhosis was alcohol (39%). The mean RRI for the study cohort was 0.68 ± 0.09, showing a progressive increase with higher Child-Pugh class of cirrhosis. Overall, AKI was present in 129 (64.5%) patients. The mean RRI was significantly higher in patients with AKI compared to those without it (0.72 ± 0.06 vs 0.60 ± 0.08; P < 0.001). A total of 82 patients (41%) had hepatorenal syndrome (HRS)-AKI, 29 (22.4%) had prerenal AKI (PRA), and 18 (13.9%) had acute tubular necrosis (ATN)-AKI. The mean RRI was significantly higher in the ATN-AKI (0.80 ± 0.02) and HRS-AKI (0.73 ± 0.03) groups than in the PRA (0.63 ± 0.07) and non-AKI (0.60 ± 0.07) groups. RRI demonstrated excellent discriminatory ability in distinguishing ATN-AKI from non-ATN-AKI (area under ROC curve: 93.9%). AKI emerged as an independent predictor of high RRI (adjusted odds ratio [OR]: 11.52), and high RRI independently predicted mortality among AKI patients (adjusted OR: 3.18).

Conclusion: In cirrhosis patients, RRI exhibited a significant association with AKI, effectively differentiated between AKI phenotypes, and predicted AKI mortality.

背景:肝硬化患者的血流动力学改变会导致肾血管收缩,最终引起急性肾损伤(AKI)。肾脏阻力指数(RRI)是测量肾内血管阻力最常用的多普勒超声变量。目的:评估肝硬化患者的肾脏阻力指数与 AKI 的关系,并确定高肾脏阻力指数的风险因素:这是一项前瞻性观察研究,使用多普勒超声测量了连续住院的 200 名肝硬化患者的 RRI。研究了 RRI 与 AKI 的关系。利用接收者操作特征(ROC)曲线分析确定了各种 AKI 表型的 RRI 鉴别临界值。进行了多变量分析以确定高 RRI 的预测因素:患者平均年龄为(49.08 ± 11.68)岁,大多数(79.5%)为男性;肝硬化的主要病因是酒精(39%)。研究队列的平均 RRI 为 0.68 ± 0.09,显示随着肝硬化 Child-Pugh 分级的升高而逐渐升高。总体而言,129 例(64.5%)患者出现了 AKI。与无 AKI 患者相比,有 AKI 患者的平均 RRI 明显更高(0.72 ± 0.06 vs 0.60 ± 0.08;P < 0.001)。共有 82 名患者(41%)患有肝肾综合征(HRS)-AKI,29 名患者(22.4%)患有肾前性 AKI(PRA),18 名患者(13.9%)患有急性肾小管坏死(ATN)-AKI。ATN-AKI 组(0.80 ± 0.02)和 HRS-AKI 组(0.73 ± 0.03)的平均 RRI 明显高于 PRA 组(0.63 ± 0.07)和非 AKI 组(0.60 ± 0.07)。RRI 在区分 ATN-AKI 和非 ATN-AKI 方面表现出卓越的鉴别能力(ROC 曲线下面积:93.9%)。AKI是高RRI的独立预测因素(调整后比值比[OR]:11.52),高RRI可独立预测AKI患者的死亡率(调整后比值比:3.18):肝硬化患者的 RRI 与 AKI 有显著关联,能有效区分 AKI 表型并预测 AKI 死亡率。
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引用次数: 0
Practical approach to linear endoscopic ultrasound examination of the gallbladder. 胆囊线性内窥镜超声波检查实用方法。
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-28 DOI: 10.4329/wjr.v16.i6.184
Hussein Hassan Okasha, Eyad Gadour, Hassan Atalla, Omar AbdAllah AbdEl-Hameed, Reem Ezzat, Ahmed Elsayed Alzamzamy, Elsayed Ghoneem, Rasha Ahmad Matar, Zeinab Hassan, Bogdan Miutescu, Ayman Qawasmi, Katarzyna M Pawlak, Ahmed Elmeligui

The gallbladder (GB) is a susceptible organ, prone to various pathologies that can be identified using different imaging techniques. Transabdominal ultrasound (TUS) is typically the initial diagnostic method due to its numerous well-established advantages. However, in cases of uncertainty or when a definitive diagnosis cannot be established, computed tomography (CT) or magnetic resonance imaging may be employed to provide more detailed information. Nevertheless, CT scans may sometimes offer inadequate spatial resolution, which can limit the differentiation of GB lesions, particularly when smaller yet clinically relevant abnormalities are involved. Conversely, endoscopic ultrasound (EUS) provides higher frequency compared to TUS, superior spatial resolution, and the option for contrast-enhanced harmonic imaging, enabling a more comprehensive examination. Thus, EUS can serve as a supplementary tool when conventional imaging methods are insufficient. This review will describe the standard EUS examination of the GB, focusing on its endosonographic characteristics in various GB pathologies.

胆囊(GB)是一个易感器官,容易发生各种病变,可通过不同的成像技术进行识别。经腹超声(TUS)因其众多公认的优点,通常是最初的诊断方法。不过,在不确定或无法确定诊断的情况下,可采用计算机断层扫描(CT)或磁共振成像来提供更详细的信息。不过,CT 扫描有时可能无法提供足够的空间分辨率,从而限制了对 GB 病变的区分,尤其是涉及较小但与临床相关的异常时。相反,与 TUS 相比,内窥镜超声(EUS)的频率更高,空间分辨率更高,并可进行对比度增强谐波成像,从而实现更全面的检查。因此,EUS 可作为常规成像方法不足时的辅助工具。本综述将介绍标准的胃肠道超声检查,重点是各种胃肠道病变的内镜特征。
{"title":"Practical approach to linear endoscopic ultrasound examination of the gallbladder.","authors":"Hussein Hassan Okasha, Eyad Gadour, Hassan Atalla, Omar AbdAllah AbdEl-Hameed, Reem Ezzat, Ahmed Elsayed Alzamzamy, Elsayed Ghoneem, Rasha Ahmad Matar, Zeinab Hassan, Bogdan Miutescu, Ayman Qawasmi, Katarzyna M Pawlak, Ahmed Elmeligui","doi":"10.4329/wjr.v16.i6.184","DOIUrl":"10.4329/wjr.v16.i6.184","url":null,"abstract":"<p><p>The gallbladder (GB) is a susceptible organ, prone to various pathologies that can be identified using different imaging techniques. Transabdominal ultrasound (TUS) is typically the initial diagnostic method due to its numerous well-established advantages. However, in cases of uncertainty or when a definitive diagnosis cannot be established, computed tomography (CT) or magnetic resonance imaging may be employed to provide more detailed information. Nevertheless, CT scans may sometimes offer inadequate spatial resolution, which can limit the differentiation of GB lesions, particularly when smaller yet clinically relevant abnormalities are involved. Conversely, endoscopic ultrasound (EUS) provides higher frequency compared to TUS, superior spatial resolution, and the option for contrast-enhanced harmonic imaging, enabling a more comprehensive examination. Thus, EUS can serve as a supplementary tool when conventional imaging methods are insufficient. This review will describe the standard EUS examination of the GB, focusing on its endosonographic characteristics in various GB pathologies.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating nephrotoxic waters: A comprehensive overview of contrast-induced acute kidney injury prevention. 在肾毒性水域中航行:造影剂诱发急性肾损伤预防综合概述。
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-28 DOI: 10.4329/wjr.v16.i6.168
Panagiotis Theofilis, Rigas Kalaitzidis

Contrast-induced acute kidney injury (CI-AKI) is the third leading cause of acute kidney injury deriving from the intravascular administration of contrast media in diagnostic and therapeutic procedures and leading to longer in-hospital stay and increased short and long-term mortality. Its pathophysiology, although not well-established, revolves around medullary hypoxia paired with the direct toxicity of the substance to the kidney. Critically ill patients, as well as those with pre-existing renal disease and cardiovascular comorbidities, are more susceptible to CI-AKI. Despite the continuous research in the field of CI-AKI prevention, clinical practice is based mostly on periprocedural hydration. In this review, all the investigated methods of prevention are presented, with an emphasis on the latest evidence regarding the potential of RenalGuard and contrast removal systems for CI-AKI prevention in high-risk individuals.

造影剂诱发的急性肾损伤(CI-AKI)是诊断和治疗过程中血管内使用造影剂导致急性肾损伤的第三大主要原因,会导致住院时间延长、短期和长期死亡率上升。尽管其病理生理学尚未得到很好的证实,但它是围绕髓质缺氧和物质对肾脏的直接毒性而产生的。重症患者以及原有肾脏疾病和心血管并发症的患者更容易发生 CI-AKI。尽管在 CI-AKI 预防领域的研究仍在继续,但临床实践主要基于围手术期水化。本综述介绍了所有研究过的预防方法,重点是有关 RenalGuard 和造影剂清除系统在预防高危人群 CI-AKI 方面潜力的最新证据。
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引用次数: 0
Imaging features and management of focal liver lesions. 肝脏局灶性病变的成像特征和处理方法。
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-28 DOI: 10.4329/wjr.v16.i6.139
Gökhan Kahraman, Kemal Murat Haberal, Osman Nuri Dilek

Notably, the number of incidentally detected focal liver lesions (FLLs) has increased dramatically in recent years due to the increased use of radiological imaging. The diagnosis of FLLs can be made through a well-documented medical history, physical examination, laboratory tests, and appropriate imaging methods. Although benign FLLs are more common than malignant ones in adults, even in patients with primary malignancy, accurate diagnosis of incidental FLLs is of utmost clinical significance. In clinical practice, FLLs are frequently evaluated non-invasively using ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Although US is a cost-effective and widely used imaging method, its diagnostic specificity and sensitivity for FLL characterization are limited. FLLs are primarily characterized by obtaining enhancement patterns through dynamic contrast-enhanced CT and MRI. MRI is a problem-solving method with high specificity and sensitivity, commonly used for the evaluation of FLLs that cannot be characterized by US or CT. Recent technical advancements in MRI, along with the use of hepatobiliary-specific MRI contrast agents, have significantly improved the success of FLL characterization and reduced unnecessary biopsies. The American College of Radiology (ACR) appropriateness criteria are evidence-based recommendations intended to assist clinicians in selecting the optimal imaging or treatment option for their patients. ACR Appropriateness Criteria Liver Lesion-Initial Characterization guideline provides recommendations for the imaging methods that should be used for the characterization of incidentally detected FLLs in various clinical scenarios. The American College of Gastroenterology (ACG) Clinical Guideline offers evidence-based recommendations for both the diagnosis and management of FLL. American Association for the Study of Liver Diseases (AASLD) Practice Guidance provides an approach to the diagnosis and management of patients with hepatocellular carcinoma. In this article, FLLs are reviewed with a comprehensive analysis of ACR Appropriateness Criteria, ACG Clinical Guideline, AASLD Practice Guidance, and current medical literature from peer-reviewed journals. The article includes a discussion of imaging methods used for the assessment of FLL, current recommended imaging techniques, innovations in liver imaging, contrast agents, imaging features of common nonmetastatic benign and malignant FLL, as well as current management recommendations.

值得注意的是,近年来,由于放射成像技术的应用日益广泛,偶然发现的局灶性肝损伤(FLLs)数量急剧增加。FLL的诊断可通过翔实的病史、体格检查、实验室检查和适当的影像学方法来完成。虽然在成人中良性 FLL 比恶性 FLL 更为常见,但即使在原发性恶性肿瘤患者中,准确诊断偶然出现的 FLL 也具有极其重要的临床意义。在临床实践中,经常使用超声波(US)、计算机断层扫描(CT)和磁共振成像(MRI)对 FLL 进行无创评估。尽管 US 是一种成本效益高且应用广泛的成像方法,但其对 FLL 特征描述的诊断特异性和灵敏度却很有限。FLL 的特征主要是通过动态对比增强 CT 和 MRI 获得增强模式。核磁共振成像是一种解决问题的方法,具有高特异性和高灵敏度,常用于评估 US 或 CT 无法定性的 FLL。核磁共振成像的最新技术进步以及肝胆特异性核磁共振成像造影剂的使用,大大提高了FLL特征描述的成功率,并减少了不必要的活检。美国放射学会(ACR)适宜性标准是以证据为基础的建议,旨在帮助临床医生为患者选择最佳的成像或治疗方案。ACR 适当性标准肝脏病变-初始特征描述指南为在各种临床情况下偶然发现的 FLL 特征描述所应使用的成像方法提供了建议。美国胃肠病学院 (ACG) 临床指南为 FLL 的诊断和管理提供了循证建议。美国肝病研究协会(AASLD)实践指南提供了肝细胞癌患者的诊断和管理方法。本文通过全面分析 ACR 适宜性标准、ACG 临床指南、AASLD 实践指南以及同行评审期刊中的最新医学文献,对 FLL 进行了综述。文章讨论了用于评估FLL的成像方法、当前推荐的成像技术、肝脏成像的创新、造影剂、常见非转移性良性和恶性FLL的成像特征以及当前的管理建议。
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引用次数: 0
Predicting distant metastasis in nasopharyngeal carcinoma using gradient boosting tree model based on detailed magnetic resonance imaging reports. 利用基于详细磁共振成像报告的梯度增强树模型预测鼻咽癌的远处转移
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-28 DOI: 10.4329/wjr.v16.i6.203
Yu-Liang Zhu, Xin-Lei Deng, Xu-Cheng Zhang, Li Tian, Chun-Yan Cui, Feng Lei, Gui-Qiong Xu, Hao-Jiang Li, Li-Zhi Liu, Hua-Li Ma

Background: Development of distant metastasis (DM) is a major concern during treatment of nasopharyngeal carcinoma (NPC). However, studies have demonstrated improved distant control and survival in patients with advanced NPC with the addition of chemotherapy to concomitant chemoradiotherapy. Therefore, precise prediction of metastasis in patients with NPC is crucial.

Aim: To develop a predictive model for metastasis in NPC using detailed magnetic resonance imaging (MRI) reports.

Methods: This retrospective study included 792 patients with non-distant metastatic NPC. A total of 469 imaging variables were obtained from detailed MRI reports. Data were stratified and randomly split into training (50%) and testing sets. Gradient boosting tree (GBT) models were built and used to select variables for predicting DM. A full model comprising all variables and a reduced model with the top-five variables were built. Model performance was assessed by area under the curve (AUC).

Results: Among the 792 patients, 94 developed DM during follow-up. The number of metastatic cervical nodes (30.9%), tumor invasion in the posterior half of the nasal cavity (9.7%), two sides of the pharyngeal recess (6.2%), tubal torus (3.3%), and single side of the parapharyngeal space (2.7%) were the top-five contributors for predicting DM, based on their relative importance in GBT models. The testing AUC of the full model was 0.75 (95% confidence interval [CI]: 0.69-0.82). The testing AUC of the reduced model was 0.75 (95%CI: 0.68-0.82). For the whole dataset, the full (AUC = 0.76, 95%CI: 0.72-0.82) and reduced models (AUC = 0.76, 95%CI: 0.71-0.81) outperformed the tumor node-staging system (AUC = 0.67, 95%CI: 0.61-0.73).

Conclusion: The GBT model outperformed the tumor node-staging system in predicting metastasis in NPC. The number of metastatic cervical nodes was identified as the principal contributing variable.

背景:远处转移(DM)的发生是鼻咽癌(NPC)治疗过程中的一个主要问题。然而,有研究表明,在化疗的同时加用化疗放疗可改善晚期鼻咽癌患者的远处转移控制和生存率。因此,准确预测鼻咽癌患者的转移至关重要。目的:利用详细的磁共振成像(MRI)报告建立鼻咽癌转移预测模型:这项回顾性研究纳入了792例非远处转移性鼻咽癌患者。从详细的磁共振成像报告中获得了总共 469 个成像变量。数据被分层并随机分成训练集(50%)和测试集。建立梯度提升树(GBT)模型,用于选择预测 DM 的变量。建立了一个包含所有变量的完整模型和一个包含前五个变量的简化模型。通过曲线下面积(AUC)评估模型性能:结果:在792名患者中,有94人在随访期间发生了DM。根据其在GBT模型中的相对重要性,转移性颈结节数量(30.9%)、鼻腔后半部肿瘤侵犯(9.7%)、两侧咽凹(6.2%)、输卵管环(3.3%)和单侧咽旁间隙(2.7%)是预测DM的前五大因素。完整模型的测试AUC为0.75(95%置信区间[CI]:0.69-0.82)。简化模型的测试 AUC 为 0.75(95% 置信区间:0.68-0.82)。就整个数据集而言,完整模型(AUC = 0.76,95%CI:0.72-0.82)和简化模型(AUC = 0.76,95%CI:0.71-0.81)的表现优于肿瘤结节分期系统(AUC = 0.67,95%CI:0.61-0.73):结论:在预测鼻咽癌转移方面,GBT模型优于肿瘤结节分期系统。结论:在预测鼻咽癌转移方面,GBT 模型优于肿瘤结节分期系统。
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引用次数: 0
Multisystemic recurrent Langerhans cell histiocytosis misdiagnosed with chronic inflammation at the first diagnosis: A case report. 初诊时被误诊为慢性炎症的多系统复发性朗格汉斯细胞组织细胞增生症:病例报告。
IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-28 DOI: 10.4329/wjr.v16.i6.232
Zhan-Rong Zhang, Feng Chen, Hui-Juan Chen

Background: Langerhans cell histiocytosis (LCH) is characterized by diabetes insipidus and is an uncommon occurrence. Pathological biopsies still have a certain degree of diagnostic probability. We present a case in which LCH initially affected the pituitary gland. This resulted in a misdiagnosis of chronic inflammation upon pathological examination.

Case summary: A 25-year-old female exhibited symptoms of diabetes insipidus. Magnetic resonance imaging revealed an enhanced foci in the pituitary gland. After surgical resection of the pituitary lesion, the pathological diagnosis was chronic inflammation. However, the patient later experienced bone destruction in the skull and lower limb bones. After the lower limb bone lesion was compared with the initial pituitary lesion, the final diagnosis was modified to LCH. The patient was treated with multiple chemotherapy courses. However, the patient's condition gradually worsened, and she eventually passed away at home.

Conclusion: LCH should be considered when patients exhibit diabetes insipidus and absence of high signal intensity in the pituitary gland on sagittal T1-weighted image and abnormal enhancement in the pituitary region.

背景:朗格汉斯细胞组织细胞增生症(Langerhans cell histiocytosis,LCH)以糖尿病性尿崩症为特征,并不常见。病理活检仍有一定的诊断可能性。我们介绍了一例 LCH 最初累及垂体的病例。病例摘要:一名 25 岁女性表现出糖尿病症状。磁共振成像显示垂体有强化灶。手术切除垂体病灶后,病理诊断为慢性炎症。然而,患者的颅骨和下肢骨后来出现了骨质破坏。将下肢骨病变与最初的垂体病变进行比较后,最终诊断改为 LCH。患者接受了多个疗程的化疗。然而,患者的病情逐渐恶化,最终在家中去世:结论:当患者出现糖尿病性尿崩症,矢状面T1加权图像上垂体无高信号强度,垂体区域异常强化时,应考虑LCH。
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引用次数: 0
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World journal of radiology
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