首页 > 最新文献

World journal of radiology最新文献

英文 中文
Chronic pancreatitis: Pain and computed tomography/magnetic resonance imaging findings. 慢性胰腺炎:疼痛与计算机断层扫描/磁共振成像结果。
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-03-28 DOI: 10.4329/wjr.v16.i3.40
Yue Feng, Ling-Ji Song, Bo Xiao

Chronic pancreatitis (CP) is a fibroinflammatory disease characterized by irreversible destruction of pancreatic tissue. With the development of the disease, it may lead to exocrine and/or endocrine insufficiency. CP is one of the common diseases that cause abdominal pain, which will not get permanent spontaneous relief as the disease evolves. The American College of Gastroenterology clinical guidelines recommend computed tomography or magnetic resonance imaging as the first-line examination for the diagnosis of CP. CP common imaging findings include pancreatic atrophy, irregular dilatation of the pancreatic duct, calcification of pancreatic parenchyma, pancreatic duct stones, etc. In clinical practice, whether any correlations between CP-induced abdominal pain patterns (no pain/constant/intermittent pain) and corresponding imaging findings present are not well known. Therefore, this review aims to comprehensively sort out and analyze the relevant information by collecting lots of literature on this field, so as to construct a cross-bridge between the clinical manifestations and imaging manifestations of CP patients. Also, it provides an imaging basis and foundation for the classification and diagnosis of abdominal pain types in clinical CP patients.

慢性胰腺炎(CP)是一种以胰腺组织不可逆转的破坏为特征的纤维炎性疾病。随着病情的发展,可能会导致外分泌和/或内分泌功能不全。CP 是导致腹痛的常见疾病之一,随着病情的发展,腹痛不会永久性自发缓解。美国胃肠病学会临床指南建议将计算机断层扫描或磁共振成像作为诊断 CP 的一线检查方法。CP 常见的影像学表现包括胰腺萎缩、胰管不规则扩张、胰腺实质钙化、胰管结石等。在临床实践中,CP 引起的腹痛模式(无痛/剧烈/间歇性疼痛)与相应的影像学检查结果之间是否存在相关性尚不清楚。因此,本综述旨在通过收集该领域的大量文献,全面梳理和分析相关信息,从而在 CP 患者的临床表现和影像学表现之间架起一座桥梁。同时,也为临床 CP 患者腹痛类型的分类和诊断提供影像学依据和基础。
{"title":"Chronic pancreatitis: Pain and computed tomography/magnetic resonance imaging findings.","authors":"Yue Feng, Ling-Ji Song, Bo Xiao","doi":"10.4329/wjr.v16.i3.40","DOIUrl":"https://doi.org/10.4329/wjr.v16.i3.40","url":null,"abstract":"<p><p>Chronic pancreatitis (CP) is a fibroinflammatory disease characterized by irreversible destruction of pancreatic tissue. With the development of the disease, it may lead to exocrine and/or endocrine insufficiency. CP is one of the common diseases that cause abdominal pain, which will not get permanent spontaneous relief as the disease evolves. The American College of Gastroenterology clinical guidelines recommend computed tomography or magnetic resonance imaging as the first-line examination for the diagnosis of CP. CP common imaging findings include pancreatic atrophy, irregular dilatation of the pancreatic duct, calcification of pancreatic parenchyma, pancreatic duct stones, <i>etc.</i> In clinical practice, whether any correlations between CP-induced abdominal pain patterns (no pain/constant/intermittent pain) and corresponding imaging findings present are not well known. Therefore, this review aims to comprehensively sort out and analyze the relevant information by collecting lots of literature on this field, so as to construct a cross-bridge between the clinical manifestations and imaging manifestations of CP patients. Also, it provides an imaging basis and foundation for the classification and diagnosis of abdominal pain types in clinical CP patients.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 3","pages":"40-48"},"PeriodicalIF":2.5,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10999955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes and efficacy of magnetic resonance imaging-compatible sacral nerve stimulator for management of fecal incontinence: A multi-institutional study. 磁共振成像兼容骶神经刺激器治疗大便失禁的结果和疗效:一项多机构研究。
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-28 DOI: 10.4329/wjr.v16.i2.32
Binit Katuwal, Amy Thorsen, Kunal Kochar, Ryba Bhullar, Ray King, Ernesto Raul Drelichman, Vijay K Mittal, Jasneet Singh Bhullar

Background: Fecal incontinence (FI) is an involuntary passage of fecal matter which can have a significant impact on a patient's quality of life. Many modalities of treatment exist for FI. Sacral nerve stimulation is a well-established treatment for FI. Given the increased need of magnetic resonance imaging (MRI) for diagnostics, the InterStim which was previously used in sacral nerve stimulation was limited by MRI incompatibility. Medtronic MRI-compatible InterStim was approved by the United States Food and Drug Administration in August 2020 and has been widely used.

Aim: To evaluate the efficacy, outcomes and complications of the MRI-compatible InterStim.

Methods: Data of patients who underwent MRI-compatible Medtronic InterStim placement at UPMC Williamsport, University of Minnesota, Advocate Lutheran General Hospital, and University of Wisconsin-Madison was pooled and analyzed. Patient demographics, clinical features, surgical techniques, complications, and outcomes were analyzed. Strengthening the Reporting of Observational studies in Epidemiology(STROBE) cross-sectional reporting guidelines were used.

Results: Seventy-three patients had the InterStim implanted. The mean age was 63.29 ± 12.2 years. Fifty-seven (78.1%) patients were females and forty-two (57.5%) patients had diabetes. In addition to incontinence, overlapping symptoms included diarrhea (23.3%), fecal urgency (58.9%), and urinary incontinence (28.8%). Fifteen (20.5%) patients underwent Peripheral Nerve Evaluation before proceeding to definite implant placement. Thirty-two (43.8%) patients underwent rechargeable InterStim placement. Three (4.1%) patients needed removal of the implant. Migration of the external lead connection was observed in 7 (9.6%) patients after the stage I procedure. The explanation for one patient was due to infection. Seven (9.6%) patients had other complications like nerve pain, hematoma, infection, lead fracture, and bleeding. The mean follow-up was 6.62 ± 3.5 mo. Sixty-eight (93.2%) patients reported significant improvement of symptoms on follow-up evaluation.

Conclusion: This study shows promising results with significant symptom improvement, good efficacy and good patient outcomes with low complication rates while using MRI compatible InterStim for FI. Further long-term follow-up and future studies with a larger patient population is recommended.

背景:大便失禁(FI)是指粪便不自主地排出,对患者的生活质量有很大影响。治疗大便失禁的方法有很多。骶神经刺激是治疗 FI 的一种行之有效的方法。鉴于磁共振成像(MRI)在诊断方面的需求日益增加,以前用于骶神经刺激的 InterStim 因与 MRI 不兼容而受到限制。美敦力公司与核磁共振成像兼容的 InterStim 于 2020 年 8 月获得美国食品和药物管理局批准,并得到广泛应用。目的:评估与核磁共振成像兼容的 InterStim 的疗效、结果和并发症:汇集并分析了在UPMC Williamsport、明尼苏达大学、Advocate Lutheran综合医院和威斯康星大学麦迪逊分校接受MRI兼容美敦力InterStim置入术的患者数据。分析了患者的人口统计学特征、临床特征、手术技术、并发症和结果。研究采用了加强流行病学观察性研究报告(STROBE)横断面报告指南:73名患者植入了InterStim。平均年龄为 63.29 ± 12.2 岁。57名(78.1%)患者为女性,42名(57.5%)患者患有糖尿病。除尿失禁外,重叠症状还包括腹泻(23.3%)、便急(58.9%)和尿失禁(28.8%)。15名患者(20.5%)在确定植入前接受了周围神经评估。32名(43.8%)患者接受了可充电 InterStim 植入术。三名(4.1%)患者需要移除植入物。在第一阶段手术后,有 7 名患者(9.6%)的外部导线连接出现移位。其中一名患者的原因是感染。7例(9.6%)患者出现了其他并发症,如神经痛、血肿、感染、导联骨折和出血。平均随访时间为 6.62±3.5 个月,68 名(93.2%)患者在随访评估中报告症状明显改善:这项研究表明,在使用磁共振成像兼容 InterStim 治疗脑梗死的过程中,患者症状明显改善,疗效良好,并发症发生率低,患者预后良好。建议进一步进行长期随访,并在未来对更多患者进行研究。
{"title":"Outcomes and efficacy of magnetic resonance imaging-compatible sacral nerve stimulator for management of fecal incontinence: A multi-institutional study.","authors":"Binit Katuwal, Amy Thorsen, Kunal Kochar, Ryba Bhullar, Ray King, Ernesto Raul Drelichman, Vijay K Mittal, Jasneet Singh Bhullar","doi":"10.4329/wjr.v16.i2.32","DOIUrl":"10.4329/wjr.v16.i2.32","url":null,"abstract":"<p><strong>Background: </strong>Fecal incontinence (FI) is an involuntary passage of fecal matter which can have a significant impact on a patient's quality of life. Many modalities of treatment exist for FI. Sacral nerve stimulation is a well-established treatment for FI. Given the increased need of magnetic resonance imaging (MRI) for diagnostics, the InterStim which was previously used in sacral nerve stimulation was limited by MRI incompatibility. Medtronic MRI-compatible InterStim was approved by the United States Food and Drug Administration in August 2020 and has been widely used.</p><p><strong>Aim: </strong>To evaluate the efficacy, outcomes and complications of the MRI-compatible InterStim.</p><p><strong>Methods: </strong>Data of patients who underwent MRI-compatible Medtronic InterStim placement at UPMC Williamsport, University of Minnesota, Advocate Lutheran General Hospital, and University of Wisconsin-Madison was pooled and analyzed. Patient demographics, clinical features, surgical techniques, complications, and outcomes were analyzed. Strengthening the Reporting of Observational studies in Epidemiology(STROBE) cross-sectional reporting guidelines were used.</p><p><strong>Results: </strong>Seventy-three patients had the InterStim implanted. The mean age was 63.29 ± 12.2 years. Fifty-seven (78.1%) patients were females and forty-two (57.5%) patients had diabetes. In addition to incontinence, overlapping symptoms included diarrhea (23.3%), fecal urgency (58.9%), and urinary incontinence (28.8%). Fifteen (20.5%) patients underwent Peripheral Nerve Evaluation before proceeding to definite implant placement. Thirty-two (43.8%) patients underwent rechargeable InterStim placement. Three (4.1%) patients needed removal of the implant. Migration of the external lead connection was observed in 7 (9.6%) patients after the stage I procedure. The explanation for one patient was due to infection. Seven (9.6%) patients had other complications like nerve pain, hematoma, infection, lead fracture, and bleeding. The mean follow-up was 6.62 ± 3.5 mo. Sixty-eight (93.2%) patients reported significant improvement of symptoms on follow-up evaluation.</p><p><strong>Conclusion: </strong>This study shows promising results with significant symptom improvement, good efficacy and good patient outcomes with low complication rates while using MRI compatible InterStim for FI. Further long-term follow-up and future studies with a larger patient population is recommended.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"16 2","pages":"32-39"},"PeriodicalIF":2.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methods for improving colorectal cancer annotation efficiency for artificial intelligence-observer training. 提高人工智能观察者训练结直肠癌注释效率的方法。
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-28 DOI: 10.4329/wjr.v15.i12.359
Matthew Grudza, Brandon Salinel, Sarah Zeien, Matthew Murphy, Jake Adkins, Corey T Jensen, Curtis Bay, Vikram Kodibagkar, Phillip Koo, Tomislav Dragovich, Michael A Choti, Madappa Kundranda, Tanveer Syeda-Mahmood, Hong-Zhi Wang, John Chang

Background: Missing occult cancer lesions accounts for the most diagnostic errors in retrospective radiology reviews as early cancer can be small or subtle, making the lesions difficult to detect. Second-observer is the most effective technique for reducing these events and can be economically implemented with the advent of artificial intelligence (AI).

Aim: To achieve appropriate AI model training, a large annotated dataset is necessary to train the AI models. Our goal in this research is to compare two methods for decreasing the annotation time to establish ground truth: Skip-slice annotation and AI-initiated annotation.

Methods: We developed a 2D U-Net as an AI second observer for detecting colorectal cancer (CRC) and an ensemble of 5 differently initiated 2D U-Net for ensemble technique. Each model was trained with 51 cases of annotated CRC computed tomography of the abdomen and pelvis, tested with 7 cases, and validated with 20 cases from The Cancer Imaging Archive cases. The sensitivity, false positives per case, and estimated Dice coefficient were obtained for each method of training. We compared the two methods of annotations and the time reduction associated with the technique. The time differences were tested using Friedman's two-way analysis of variance.

Results: Sparse annotation significantly reduces the time for annotation particularly skipping 2 slices at a time (P < 0.001). Reduction of up to 2/3 of the annotation does not reduce AI model sensitivity or false positives per case. Although initializing human annotation with AI reduces the annotation time, the reduction is minimal, even when using an ensemble AI to decrease false positives.

Conclusion: Our data support the sparse annotation technique as an efficient technique for reducing the time needed to establish the ground truth.

背景:在回顾性放射学审查中,遗漏隐匿性癌症病灶是最常见的诊断错误,因为早期癌症可能很小或很隐蔽,使病灶难以发现。第二观察者是减少这些事件的最有效技术,而且随着人工智能(AI)的出现,可以经济地实现第二观察者。我们的研究目标是比较两种缩短标注时间以建立地面实况的方法:跳过切片标注和人工智能启动标注:我们开发了一个二维 U-Net 作为检测结直肠癌(CRC)的人工智能第二观察者,并开发了一个由 5 个不同启动方式的二维 U-Net 组成的集合,用于集合技术。每个模型都用 51 例注释过的腹部和盆腔 CRC 计算机断层扫描图像进行了训练,用 7 例进行了测试,并用癌症成像档案中的 20 例进行了验证。得出了每种训练方法的灵敏度、每个病例的误报率和估计的 Dice 系数。我们比较了两种注释方法以及与该技术相关的时间缩减。我们使用弗里德曼双向方差分析对时间差异进行了检验:结果:稀疏标注大大缩短了标注时间,尤其是每次跳过 2 个切片(P < 0.001)。减少多达 2/3 的注释并不会降低人工智能模型的灵敏度或每个病例的误报率。虽然用人工智能初始化人类注释可以减少注释时间,但减少的时间极少,即使使用集合人工智能来减少误报也是如此:我们的数据支持稀疏注释技术,认为它是减少建立基本事实所需时间的有效技术。
{"title":"Methods for improving colorectal cancer annotation efficiency for artificial intelligence-observer training.","authors":"Matthew Grudza, Brandon Salinel, Sarah Zeien, Matthew Murphy, Jake Adkins, Corey T Jensen, Curtis Bay, Vikram Kodibagkar, Phillip Koo, Tomislav Dragovich, Michael A Choti, Madappa Kundranda, Tanveer Syeda-Mahmood, Hong-Zhi Wang, John Chang","doi":"10.4329/wjr.v15.i12.359","DOIUrl":"10.4329/wjr.v15.i12.359","url":null,"abstract":"<p><strong>Background: </strong>Missing occult cancer lesions accounts for the most diagnostic errors in retrospective radiology reviews as early cancer can be small or subtle, making the lesions difficult to detect. Second-observer is the most effective technique for reducing these events and can be economically implemented with the advent of artificial intelligence (AI).</p><p><strong>Aim: </strong>To achieve appropriate AI model training, a large annotated dataset is necessary to train the AI models. Our goal in this research is to compare two methods for decreasing the annotation time to establish ground truth: Skip-slice annotation and AI-initiated annotation.</p><p><strong>Methods: </strong>We developed a 2D U-Net as an AI second observer for detecting colorectal cancer (CRC) and an ensemble of 5 differently initiated 2D U-Net for ensemble technique. Each model was trained with 51 cases of annotated CRC computed tomography of the abdomen and pelvis, tested with 7 cases, and validated with 20 cases from The Cancer Imaging Archive cases. The sensitivity, false positives per case, and estimated Dice coefficient were obtained for each method of training. We compared the two methods of annotations and the time reduction associated with the technique. The time differences were tested using Friedman's two-way analysis of variance.</p><p><strong>Results: </strong>Sparse annotation significantly reduces the time for annotation particularly skipping 2 slices at a time (<i>P</i> < 0.001). Reduction of up to 2/3 of the annotation does not reduce AI model sensitivity or false positives per case. Although initializing human annotation with AI reduces the annotation time, the reduction is minimal, even when using an ensemble AI to decrease false positives.</p><p><strong>Conclusion: </strong>Our data support the sparse annotation technique as an efficient technique for reducing the time needed to establish the ground truth.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 12","pages":"359-369"},"PeriodicalIF":2.5,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10762523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep learning-based magnetic resonance imaging reconstruction for improving the image quality of reduced-field-of-view diffusion-weighted imaging of the pancreas. 基于深度学习的磁共振成像重建技术,用于改善胰腺减视野弥散加权成像的图像质量。
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-28 DOI: 10.4329/wjr.v15.i12.338
Yukihisa Takayama, Keisuke Sato, Shinji Tanaka, Ryo Murayama, Nahoko Goto, Kengo Yoshimitsu

Background: It has been reported that deep learning-based reconstruction (DLR) can reduce image noise and artifacts, thereby improving the signal-to-noise ratio and image sharpness. However, no previous studies have evaluated the efficacy of DLR in improving image quality in reduced-field-of-view (reduced-FOV) diffusion-weighted imaging (DWI) [field-of-view optimized and constrained undistorted single-shot (FOCUS)] of the pancreas. We hypothesized that a combination of these techniques would improve DWI image quality without prolonging the scan time but would influence the apparent diffusion coefficient calculation.

Aim: To evaluate the efficacy of DLR for image quality improvement of FOCUS of the pancreas.

Methods: This was a retrospective study evaluated 37 patients with pancreatic cystic lesions who underwent magnetic resonance imaging between August 2021 and October 2021. We evaluated three types of FOCUS examinations: FOCUS with DLR (FOCUS-DLR+), FOCUS without DLR (FOCUS-DLR-), and conventional FOCUS (FOCUS-conv). The three types of FOCUS and their apparent diffusion coefficient (ADC) maps were compared qualitatively and quantitatively.

Results: FOCUS-DLR+ (3.62, average score of two radiologists) showed significantly better qualitative scores for image noise than FOCUS-DLR- (2.62) and FOCUS-conv (2.88) (P < 0.05). Furthermore, FOCUS-DLR+ showed the highest contrast ratio (CR) between the pancreatic parenchyma and adjacent fat tissue for b-values of 0 and 600 s/mm2 (0.72 ± 0.08 and 0.68 ± 0.08) and FOCUS-DLR- showed the highest CR between cystic lesions and the pancreatic parenchyma for the b-values of 0 and 600 s/mm2 (0.62 ± 0.21 and 0.62 ± 0.21) (P < 0.05), respectively. FOCUS-DLR+ provided significantly higher ADCs of the pancreas and lesion (1.44 ± 0.24 and 3.00 ± 0.66) compared to FOCUS-DLR- (1.39 ± 0.22 and 2.86 ± 0.61) and significantly lower ADCs compared to FOCUS-conv (1.84 ± 0.45 and 3.32 ± 0.70) (P < 0.05), respectively.

Conclusion: This study evaluated the efficacy of DLR for image quality improvement in reduced-FOV DWI of the pancreas. DLR can significantly denoise images without prolonging the scan time or decreasing the spatial resolution. The denoising level of DWI can be controlled to make the images appear more natural to the human eye. However, this study revealed that DLR did not ameliorate pancreatic distortion. Additionally, physicians should pay attention to the interpretation of ADCs after DLR application because ADCs are significantly changed by DLR.

背景:据报道,基于深度学习的重建(DLR)可以减少图像噪声和伪影,从而提高信噪比和图像清晰度。然而,之前没有研究评估过 DLR 在改善胰腺缩小视场(reduced-FOV)弥散加权成像(DWI)[视场优化和受限不失真单次成像(FOCUS)]图像质量方面的功效。目的:评估 DLR 对改善胰腺 FOCUS 图像质量的效果:这是一项回顾性研究,对 2021 年 8 月至 2021 年 10 月间接受磁共振成像的 37 例胰腺囊性病变患者进行了评估。我们评估了三种类型的 FOCUS 检查:带 DLR 的 FOCUS(FOCUS-DLR+)、不带 DLR 的 FOCUS(FOCUS-DLR-)和传统 FOCUS(FOCUS-conv)。对三种 FOCUS 及其表观弥散系数(ADC)图进行了定性和定量比较:结果:FOCUS-DLR+(3.62,两名放射科医生的平均分)的图像噪音定性评分明显优于 FOCUS-DLR-(2.62)和 FOCUS-conv(2.88)(P < 0.05)。此外,在 b 值为 0 和 600 s/mm2 时,FOCUS-DLR+ 显示胰腺实质与邻近脂肪组织之间的对比度 (CR) 最高(0.72 ± 0.08 和 0.68 ± 0.08),而在 b 值为 0 和 600 s/mm2 时,FOCUS-DLR- 显示囊性病变与胰腺实质之间的对比度 (CR) 最高(0.62 ± 0.21 和 0.62 ± 0.21)(P < 0.05)。与FOCUS-DLR-(1.39±0.22和2.86±0.61)相比,FOCUS-DLR+提供的胰腺和病灶的ADCs(1.44±0.24和3.00±0.66)明显更高,而与FOCUS-conv(1.84±0.45和3.32±0.70)相比,ADCs(1.84±0.45和3.32±0.70)明显更低(P<0.05):本研究评估了 DLR 对改善胰腺减小 FOV DWI 图像质量的效果。DLR 能在不延长扫描时间或降低空间分辨率的情况下对图像进行显著去噪。可以控制 DWI 的去噪水平,使图像在人眼看来更自然。但本研究显示,DLR 并未改善胰腺失真。此外,医生应注意应用 DLR 后 ADC 的解释,因为 DLR 会显著改变 ADC。
{"title":"Deep learning-based magnetic resonance imaging reconstruction for improving the image quality of reduced-field-of-view diffusion-weighted imaging of the pancreas.","authors":"Yukihisa Takayama, Keisuke Sato, Shinji Tanaka, Ryo Murayama, Nahoko Goto, Kengo Yoshimitsu","doi":"10.4329/wjr.v15.i12.338","DOIUrl":"10.4329/wjr.v15.i12.338","url":null,"abstract":"<p><strong>Background: </strong>It has been reported that deep learning-based reconstruction (DLR) can reduce image noise and artifacts, thereby improving the signal-to-noise ratio and image sharpness. However, no previous studies have evaluated the efficacy of DLR in improving image quality in reduced-field-of-view (reduced-FOV) diffusion-weighted imaging (DWI) [field-of-view optimized and constrained undistorted single-shot (FOCUS)] of the pancreas. We hypothesized that a combination of these techniques would improve DWI image quality without prolonging the scan time but would influence the apparent diffusion coefficient calculation.</p><p><strong>Aim: </strong>To evaluate the efficacy of DLR for image quality improvement of FOCUS of the pancreas.</p><p><strong>Methods: </strong>This was a retrospective study evaluated 37 patients with pancreatic cystic lesions who underwent magnetic resonance imaging between August 2021 and October 2021. We evaluated three types of FOCUS examinations: FOCUS with DLR (FOCUS-DLR+), FOCUS without DLR (FOCUS-DLR-), and conventional FOCUS (FOCUS-conv). The three types of FOCUS and their apparent diffusion coefficient (ADC) maps were compared qualitatively and quantitatively.</p><p><strong>Results: </strong>FOCUS-DLR+ (3.62, average score of two radiologists) showed significantly better qualitative scores for image noise than FOCUS-DLR- (2.62) and FOCUS-conv (2.88) (<i>P</i> < 0.05). Furthermore, FOCUS-DLR+ showed the highest contrast ratio (CR) between the pancreatic parenchyma and adjacent fat tissue for b-values of 0 and 600 s/mm<sup>2</sup> (0.72 ± 0.08 and 0.68 ± 0.08) and FOCUS-DLR- showed the highest CR between cystic lesions and the pancreatic parenchyma for the b-values of 0 and 600 s/mm<sup>2</sup> (0.62 ± 0.21 and 0.62 ± 0.21) (<i>P</i> < 0.05), respectively. FOCUS-DLR+ provided significantly higher ADCs of the pancreas and lesion (1.44 ± 0.24 and 3.00 ± 0.66) compared to FOCUS-DLR- (1.39 ± 0.22 and 2.86 ± 0.61) and significantly lower ADCs compared to FOCUS-conv (1.84 ± 0.45 and 3.32 ± 0.70) (<i>P</i> < 0.05), respectively.</p><p><strong>Conclusion: </strong>This study evaluated the efficacy of DLR for image quality improvement in reduced-FOV DWI of the pancreas. DLR can significantly denoise images without prolonging the scan time or decreasing the spatial resolution. The denoising level of DWI can be controlled to make the images appear more natural to the human eye. However, this study revealed that DLR did not ameliorate pancreatic distortion. Additionally, physicians should pay attention to the interpretation of ADCs after DLR application because ADCs are significantly changed by DLR.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 12","pages":"338-349"},"PeriodicalIF":2.5,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10762521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with gastrointestinal stromal tumor rupture and pathological risk: A single-center retrospective study. 与胃肠道间质瘤破裂和病理风险相关的因素:单中心回顾性研究
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-28 DOI: 10.4329/wjr.v15.i12.350
Jia-Zheng Liu, Zhong-Wen Jia, Ling-Ling Sun

Background: Gastrointestinal stromal tumor (GIST) is a rare gastrointestinal mesenchymal tumor with potential malignancy. Once the tumor ruptures, regardless of tumor size and mitotic number, it can be identified into a high-risk group. It is of great significance for the diagnosis, treatment, and prognosis of GIST if non-invasive examination can be performed before surgery to accurately assess the risk of tumor.

Aim: To identify the factors associated with GIST rupture and pathological risk.

Methods: A cohort of 50 patients with GISTs, as confirmed by postoperative pathology, was selected from our hospital. Clinicopathological and computed tomography data of the patients were collected. Logistic regression analysis was used to evaluate factors associated with GIST rupture and pathological risk grade.

Results: Pathological risk grade, tumor diameter, tumor morphology, internal necrosis, gas-liquid interface, and Ki-67 index exhibited significant associations with GIST rupture (P < 0.05). Gender, tumor diameter, tumor rupture, and Ki-67 index were found to be correlated with pathological risk grade of GIST (P < 0.05). Multifactorial logistic regression analysis revealed that male gender and tumor diameter ≥ 10 cm were independent predictors of a high pathological risk grade of GIST [odds ratio (OR) = 11.12, 95% confidence interval (95%CI): 1.81-68.52, P = 0.01; OR = 22.96, 95%CI: 2.19-240.93, P = 0.01]. Tumor diameter ≥ 10 cm, irregular shape, internal necrosis, gas-liquid interface, and Ki-67 index ≥ 10 were identified as independent predictors of a high risk of GIST rupture (OR = 9.67, 95%CI: 2.15-43.56, P = 0.01; OR = 35.44, 95%CI: 4.01-313.38, P < 0.01; OR = 18.75, 95%CI: 3.40-103.34, P < 0.01; OR = 27.00, 95%CI: 3.10-235.02, P < 0.01; OR = 4.43, 95%CI: 1.10-17.92, P = 0.04).

Conclusion: Tumor diameter, tumor morphology, internal necrosis, gas-liquid, and Ki-67 index are associated with GIST rupture, while gender and tumor diameter are linked to the pathological risk of GIST. These findings contribute to our understanding of GIST and may inform non-invasive examination strategies and risk assessment for this condition.

背景:胃肠间质瘤(GIST)是一种罕见的胃肠间质瘤,具有潜在的恶性。一旦肿瘤破裂,无论肿瘤大小和有丝分裂数多少,都可被确定为高危人群。目的:确定与 GIST 破裂和病理风险相关的因素:方法:从本院选取了50名经术后病理证实的GIST患者。收集了患者的临床病理和计算机断层扫描数据。采用逻辑回归分析评估与 GIST 破裂和病理风险等级相关的因素:结果:病理风险等级、肿瘤直径、肿瘤形态、内部坏死、气液界面和 Ki-67 指数与 GIST 破裂有显著相关性(P < 0.05)。性别、肿瘤直径、肿瘤破裂和Ki-67指数与GIST的病理风险分级相关(P < 0.05)。多因素逻辑回归分析显示,男性性别和肿瘤直径≥10厘米是GIST高病理风险等级的独立预测因素[比值比(OR)=11.12,95%置信区间(95%CI):1.81-68.52,P=0.01;OR=22.96,95%CI:2.19-240.93,P=0.01]。肿瘤直径≥10 cm、形状不规则、内部坏死、气液界面和 Ki-67 指数≥10 被确定为 GIST 破裂高风险的独立预测因子(OR = 9.67,95%CI:2.15-43.56, P = 0.01; OR = 35.44, 95%CI: 4.01-313.38, P < 0.01; OR = 18.75, 95%CI: 3.40-103.34, P < 0.01; OR = 27.00, 95%CI: 3.10-235.02, P < 0.01; OR = 4.43, 95%CI: 1.10-17.92, P = 0.04):肿瘤直径、肿瘤形态、内部坏死、气液和Ki-67指数与GIST破裂相关,而性别和肿瘤直径与GIST的病理风险相关。这些发现有助于加深我们对 GIST 的了解,并可为无创检查策略和风险评估提供依据。
{"title":"Factors associated with gastrointestinal stromal tumor rupture and pathological risk: A single-center retrospective study.","authors":"Jia-Zheng Liu, Zhong-Wen Jia, Ling-Ling Sun","doi":"10.4329/wjr.v15.i12.350","DOIUrl":"10.4329/wjr.v15.i12.350","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal stromal tumor (GIST) is a rare gastrointestinal mesenchymal tumor with potential malignancy. Once the tumor ruptures, regardless of tumor size and mitotic number, it can be identified into a high-risk group. It is of great significance for the diagnosis, treatment, and prognosis of GIST if non-invasive examination can be performed before surgery to accurately assess the risk of tumor.</p><p><strong>Aim: </strong>To identify the factors associated with GIST rupture and pathological risk.</p><p><strong>Methods: </strong>A cohort of 50 patients with GISTs, as confirmed by postoperative pathology, was selected from our hospital. Clinicopathological and computed tomography data of the patients were collected. Logistic regression analysis was used to evaluate factors associated with GIST rupture and pathological risk grade.</p><p><strong>Results: </strong>Pathological risk grade, tumor diameter, tumor morphology, internal necrosis, gas-liquid interface, and Ki-67 index exhibited significant associations with GIST rupture (<i>P</i> < 0.05). Gender, tumor diameter, tumor rupture, and Ki-67 index were found to be correlated with pathological risk grade of GIST (<i>P</i> < 0.05). Multifactorial logistic regression analysis revealed that male gender and tumor diameter ≥ 10 cm were independent predictors of a high pathological risk grade of GIST [odds ratio (OR) = 11.12, 95% confidence interval (95%CI): 1.81-68.52, <i>P</i> = 0.01; OR = 22.96, 95%CI: 2.19-240.93, <i>P</i> = 0.01]. Tumor diameter ≥ 10 cm, irregular shape, internal necrosis, gas-liquid interface, and Ki-67 index ≥ 10 were identified as independent predictors of a high risk of GIST rupture (OR = 9.67, 95%CI: 2.15-43.56, <i>P</i> = 0.01; OR = 35.44, 95%CI: 4.01-313.38, <i>P</i> < 0.01; OR = 18.75, 95%CI: 3.40-103.34, <i>P</i> < 0.01; OR = 27.00, 95%CI: 3.10-235.02, <i>P</i> < 0.01; OR = 4.43, 95%CI: 1.10-17.92, <i>P</i> = 0.04).</p><p><strong>Conclusion: </strong>Tumor diameter, tumor morphology, internal necrosis, gas-liquid, and Ki-67 index are associated with GIST rupture, while gender and tumor diameter are linked to the pathological risk of GIST. These findings contribute to our understanding of GIST and may inform non-invasive examination strategies and risk assessment for this condition.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 12","pages":"350-358"},"PeriodicalIF":2.5,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10762522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between late gadolinium enhancement and outcome in dilated cardiomyopathy: A meta-analysis. 扩张型心肌病晚期钆增强与预后的关系:一项荟萃分析。
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-11-28 DOI: 10.4329/wjr.v15.i11.324
Xin-Yi Feng, Wen-Feng He, Tian-Yue Zhang, Ling-Li Wang, Fan Yang, Yu-Ling Feng, Chun-Ping Li, Rui Li

Background: The prognostic value of late gadolinium enhancement (LGE) derived from cardiovascular magnetic resonance (CMR) is well studied, and several new metrics of LGE have emerged. However, some controversies remain; therefore, further discussion is needed, and more precise risk stratification should be explored.

Aim: To investigate the associations between the positivity, extent, location, and pattern of LGE and multiple outcomes in dilated cardiomyopathy (DCM).

Methods: PubMed, Ovid MEDLINE, and Cochrane Library were searched for studies that investigated the prognostic value of LGE in patients with DCM. Pooled hazard ratios (HRs) and 95% confidence intervals were calculated to assess the role of LGE in the risk stratification of DCM.

Results: Nineteen studies involving 7330 patients with DCM were included in this meta-analysis and covered a wide spectrum of DCM, with a mean left ventricular ejection fraction between 21% and 50%. The meta-analysis revealed that the presence of LGE was associated with an increased risk of multiple adverse outcomes (all-cause mortality, HR: 2.14; arrhythmic events, HR: 5.12; and composite endpoints, HR: 2.38; all P < 0.001). Furthermore, every 1% increment in the extent of LGE was associated with an increased risk of all-cause mortality. Analysis of a subgroup revealed that the prognostic value varied based on different location and pattern of LGE. Additionally, we found that LGE was a stronger predictor of arrhythmic events in patients with greater left ventricular ejection fraction.

Conclusion: LGE by CMR in patients with DCM exhibited a substantial value in predicting adverse outcomes, and the extent, location, and pattern of LGE could provide additional information for risk stratification.

背景:心血管磁共振(CMR)晚期钆增强(LGE)的预后价值已经得到了很好的研究,并且出现了一些新的LGE指标。然而,仍然存在一些争议;因此,需要进一步讨论,探索更精确的风险分层。目的:探讨扩张型心肌病(DCM)患者LGE阳性、程度、部位、形态与多种预后的关系。方法:检索PubMed、Ovid MEDLINE和Cochrane图书馆,寻找LGE对DCM患者预后价值的研究。计算合并风险比(hr)和95%置信区间,以评估LGE在DCM风险分层中的作用。结果:本荟萃分析纳入了19项研究,涉及7330例DCM患者,涵盖了DCM的广泛范围,平均左室射血分数在21%至50%之间。荟萃分析显示,LGE的存在与多种不良结局的风险增加相关(全因死亡率,HR: 2.14;心律失常事件,HR: 5.12;复合终点,HR: 2.38;P < 0.001)。此外,LGE范围每增加1%,全因死亡风险就会增加。亚组分析显示,LGE的位置和类型不同,其预后价值也不同。此外,我们发现LGE是左室射血分数较高的患者心律失常事件的一个更强的预测因子。结论:CMR LGE对DCM患者不良结局的预测具有重要价值,LGE的范围、位置和模式可为风险分层提供额外信息。
{"title":"Association between late gadolinium enhancement and outcome in dilated cardiomyopathy: A meta-analysis.","authors":"Xin-Yi Feng, Wen-Feng He, Tian-Yue Zhang, Ling-Li Wang, Fan Yang, Yu-Ling Feng, Chun-Ping Li, Rui Li","doi":"10.4329/wjr.v15.i11.324","DOIUrl":"10.4329/wjr.v15.i11.324","url":null,"abstract":"<p><strong>Background: </strong>The prognostic value of late gadolinium enhancement (LGE) derived from cardiovascular magnetic resonance (CMR) is well studied, and several new metrics of LGE have emerged. However, some controversies remain; therefore, further discussion is needed, and more precise risk stratification should be explored.</p><p><strong>Aim: </strong>To investigate the associations between the positivity, extent, location, and pattern of LGE and multiple outcomes in dilated cardiomyopathy (DCM).</p><p><strong>Methods: </strong>PubMed, Ovid MEDLINE, and Cochrane Library were searched for studies that investigated the prognostic value of LGE in patients with DCM. Pooled hazard ratios (HRs) and 95% confidence intervals were calculated to assess the role of LGE in the risk stratification of DCM.</p><p><strong>Results: </strong>Nineteen studies involving 7330 patients with DCM were included in this meta-analysis and covered a wide spectrum of DCM, with a mean left ventricular ejection fraction between 21% and 50%. The meta-analysis revealed that the presence of LGE was associated with an increased risk of multiple adverse outcomes (all-cause mortality, HR: 2.14; arrhythmic events, HR: 5.12; and composite endpoints, HR: 2.38; all <i>P</i> < 0.001). Furthermore, every 1% increment in the extent of LGE was associated with an increased risk of all-cause mortality. Analysis of a subgroup revealed that the prognostic value varied based on different location and pattern of LGE. Additionally, we found that LGE was a stronger predictor of arrhythmic events in patients with greater left ventricular ejection fraction.</p><p><strong>Conclusion: </strong>LGE by CMR in patients with DCM exhibited a substantial value in predicting adverse outcomes, and the extent, location, and pattern of LGE could provide additional information for risk stratification.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 11","pages":"324-337"},"PeriodicalIF":2.5,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiomics analysis with three-dimensional and two-dimensional segmentation to predict survival outcomes in pancreatic cancer. 三维和二维分割放射组学分析预测胰腺癌的生存结果。
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-11-28 DOI: 10.4329/wjr.v15.i11.304
Mohammed Saleh, Mayur Virarkar, Hagar S Mahmoud, Vincenzo K Wong, Carlos Ignacio Gonzalez Baerga, Miti Parikh, Sherif B Elsherif, Priya R Bhosale

Background: Radiomics can assess prognostic factors in several types of tumors, but considering its prognostic ability in pancreatic cancer has been lacking.

Aim: To evaluate the performance of two different radiomics software in assessing survival outcomes in pancreatic cancer patients.

Methods: We retrospectively reviewed pretreatment contrast-enhanced dual-energy computed tomography images from 48 patients with biopsy-confirmed pancreatic ductal adenocarcinoma who later underwent neoadjuvant chemoradiation and surgery. Tumors were segmented using TexRad software for 2-dimensional (2D) analysis and MIM software for 3D analysis, followed by radiomic feature extraction. Cox proportional hazard modeling correlated texture features with overall survival (OS) and progression-free survival (PFS). Cox regression was used to detect differences in OS related to pretreatment tumor size and residual tumor following treatment. The Wilcoxon test was used to show the relationship between tumor volume and the percent of residual tumor. Kaplan-Meier analysis was used to compare survival in patients with different tumor densities in Hounsfield units for both 2D and 3D analysis.

Results: 3D analysis showed that higher mean tumor density [hazard ratio (HR) = 0.971, P = 0.041)] and higher median tumor density (HR = 0.970, P = 0.037) correlated with better OS. 2D analysis showed that higher mean tumor density (HR = 0.963, P = 0.014) and higher mean positive pixels (HR = 0.962, P = 0.014) correlated with better OS; higher skewness (HR = 3.067, P = 0.008) and higher kurtosis (HR = 1.176, P = 0.029) correlated with worse OS. Higher entropy correlated with better PFS (HR = 0.056, P = 0.036). Models determined that patients with increased tumor size greater than 1.35 cm were likely to have a higher percentage of residual tumors of over 10%.

Conclusion: Several radiomics features can be used as prognostic tools for pancreatic cancer. However, results vary between 2D and 3D analyses. Mean tumor density was the only variable that could reliably predict OS, irrespective of the analysis used.

背景:放射组学可以评估多种类型肿瘤的预后因素,但尚未考虑其在胰腺癌中的预后能力。目的:评价两种不同的放射组学软件在评估胰腺癌患者生存预后方面的性能。方法:我们回顾性分析了48例活检证实的胰腺导管腺癌患者的预处理对比增强双能计算机断层扫描图像,这些患者后来接受了新辅助放化疗和手术。使用TexRad软件进行二维(2D)分析,使用MIM软件进行三维分析,然后进行放射学特征提取。Cox比例风险模型将纹理特征与总生存期(OS)和无进展生存期(PFS)相关联。采用Cox回归检测肿瘤大小与治疗后残余肿瘤相关的OS差异。采用Wilcoxon检验显示肿瘤体积与残余肿瘤百分比之间的关系。采用Kaplan-Meier分析比较Hounsfield单元中不同肿瘤密度患者的生存率,并进行二维和三维分析。结果:三维分析显示,较高的平均肿瘤密度[风险比(HR) = 0.971, P = 0.041)]和较高的中位肿瘤密度(HR = 0.970, P = 0.037)与较好的OS相关。二维分析显示,高平均肿瘤密度(HR = 0.963, P = 0.014)和高平均阳性像元(HR = 0.962, P = 0.014)与较好的OS相关;偏度越高(HR = 3.067, P = 0.008),峰度越高(HR = 1.176, P = 0.029), OS越差。熵越大,PFS越好(HR = 0.056, P = 0.036)。模型确定,肿瘤大小大于1.35 cm的患者可能有更高的残余肿瘤百分比,超过10%。结论:几种放射组学特征可作为胰腺癌的预后工具。然而,二维和三维分析的结果有所不同。无论采用何种分析,平均肿瘤密度是唯一能够可靠预测OS的变量。
{"title":"Radiomics analysis with three-dimensional and two-dimensional segmentation to predict survival outcomes in pancreatic cancer.","authors":"Mohammed Saleh, Mayur Virarkar, Hagar S Mahmoud, Vincenzo K Wong, Carlos Ignacio Gonzalez Baerga, Miti Parikh, Sherif B Elsherif, Priya R Bhosale","doi":"10.4329/wjr.v15.i11.304","DOIUrl":"10.4329/wjr.v15.i11.304","url":null,"abstract":"<p><strong>Background: </strong>Radiomics can assess prognostic factors in several types of tumors, but considering its prognostic ability in pancreatic cancer has been lacking.</p><p><strong>Aim: </strong>To evaluate the performance of two different radiomics software in assessing survival outcomes in pancreatic cancer patients.</p><p><strong>Methods: </strong>We retrospectively reviewed pretreatment contrast-enhanced dual-energy computed tomography images from 48 patients with biopsy-confirmed pancreatic ductal adenocarcinoma who later underwent neoadjuvant chemoradiation and surgery. Tumors were segmented using TexRad software for 2-dimensional (2D) analysis and MIM software for 3D analysis, followed by radiomic feature extraction. Cox proportional hazard modeling correlated texture features with overall survival (OS) and progression-free survival (PFS). Cox regression was used to detect differences in OS related to pretreatment tumor size and residual tumor following treatment. The Wilcoxon test was used to show the relationship between tumor volume and the percent of residual tumor. Kaplan-Meier analysis was used to compare survival in patients with different tumor densities in Hounsfield units for both 2D and 3D analysis.</p><p><strong>Results: </strong>3D analysis showed that higher mean tumor density [hazard ratio (HR) = 0.971, <i>P</i> = 0.041)] and higher median tumor density (HR = 0.970, <i>P</i> = 0.037) correlated with better OS. 2D analysis showed that higher mean tumor density (HR = 0.963, <i>P</i> = 0.014) and higher mean positive pixels (HR = 0.962, <i>P</i> = 0.014) correlated with better OS; higher skewness (HR = 3.067, <i>P</i> = 0.008) and higher kurtosis (HR = 1.176, <i>P</i> = 0.029) correlated with worse OS. Higher entropy correlated with better PFS (HR = 0.056, <i>P</i> = 0.036). Models determined that patients with increased tumor size greater than 1.35 cm were likely to have a higher percentage of residual tumors of over 10%.</p><p><strong>Conclusion: </strong>Several radiomics features can be used as prognostic tools for pancreatic cancer. However, results vary between 2D and 3D analyses. Mean tumor density was the only variable that could reliably predict OS, irrespective of the analysis used.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 11","pages":"304-314"},"PeriodicalIF":2.5,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters. 利用电荷耦合器件光学成像和长通滤光片对放射性核素衍生切伦科夫辐射引起的光敏剂发射进行成像评估。
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-11-28 DOI: 10.4329/wjr.v15.i11.315
Winn Aung, Atsushi B Tsuji, Kazuaki Rikiyama, Fumihiko Nishikido, Satoshi Obara, Tatsuya Higashi

Background: Radionuclides produce Cherenkov radiation (CR), which can potentially activate photosensitizers (PSs) in phototherapy. Several groups have studied Cherenkov energy transfer to PSs using optical imaging; however, cost-effectively identifying whether PSs are excited by radionuclide-derived CR and detecting fluorescence emission from excited PSs remain a challenge. Many laboratories face the need for expensive dedicated equipment.

Aim: To cost-effectively confirm whether PSs are excited by radionuclide-derived CR and distinguish fluorescence emission from excited PSs.

Methods: The absorbance and fluorescence spectra of PSs were measured using a microplate reader and fluorescence spectrometer to examine the photo-physical properties of PSs. To mitigate the need for expensive dedicated equipment and achieve the aim of the study, we developed a method that utilizes a charge-coupled device optical imaging system and appropriate long-pass filters of different wavelengths (manual sequential application of long-pass filters of 515, 580, 645, 700, 750, and 800 nm). Tetrakis (4-carboxyphenyl) porphyrin (TCPP) was utilized as a model PS. Different doses of copper-64 (64CuCl2) (4, 2, and 1 mCi) were used as CR-producing radionuclides. Imaging and data acquisition were performed 0.5 h after sample preparation. Differential image analysis was conducted by using ImageJ software (National Institutes of Health) to visually evaluate TCPP fluorescence.

Results: The maximum absorbance of TCPP was at 390-430 nm, and the emission peak was at 670 nm. The CR and CR-induced TCPP emissions were observed using the optical imaging system and the high-transmittance long-pass filters described above. The emission spectra of TCPP with a peak in the 645-700 nm window were obtained by calculation and subtraction based on the serial signal intensity (total flux) difference between 64CuCl2 + TCPP and 64CuCl2. Moreover, the differential fluorescence images of TCPP were obtained by subtracting the 64CuCl2 image from the 64CuCl2 + TCPP image. The experimental results considering different 64CuCl2 doses showed a dose-dependent trend. These results demonstrate that a bioluminescence imaging device coupled with different long-pass filters and subtraction image processing can confirm the emission spectra and differential fluorescence images of CR-induced TCPP.

Conclusion: This simple method identifies the PS fluorescence emission generated by radionuclide-derived CR and can contribute to accelerating the development of Cherenkov energy transfer imaging and the discovery of new PSs.

背景:放射性核素产生切伦科夫辐射(Cherenkov radiation, CR),在光疗中可能激活光敏剂(PSs)。几个研究小组利用光学成像研究了切伦科夫能量转移到ps;然而,经济有效地确定放射性核素衍生的CR是否激发ps并检测激发ps的荧光发射仍然是一个挑战。许多实验室都需要昂贵的专用设备。目的:经济有效地确认核素衍生的CR是否激发了ps,并区分激发后的ps的荧光发射。方法:采用微孔板阅读器和荧光光谱仪对ps的吸光度和荧光光谱进行测定,检测ps的光物理性质。为了减少对昂贵的专用设备的需求并实现研究的目的,我们开发了一种利用电荷耦合器件光学成像系统和适当的不同波长的长通滤波器的方法(手动顺序应用515、580、645、700、750和800 nm的长通滤波器)。以四(4-羧基苯基)卟啉(TCPP)作为模型PS,以不同剂量的铜-64 (64CuCl2)(4,2和1 mCi)作为产cr的放射性核素。样品制备后0.5 h进行成像和数据采集。采用ImageJ软件(美国国立卫生研究院)进行差分图像分析,直观评价TCPP荧光。结果:TCPP的最大吸光度在390 ~ 430 nm处,发射峰在670 nm处。利用光学成像系统和上述高透射率长通滤光片观察了CR和CR诱导的TCPP发射。根据64CuCl2 + TCPP与64CuCl2的串行信号强度(总通量)差值进行计算和相减,得到645 ~ 700 nm窗口内峰值的TCPP发射光谱。此外,在64CuCl2 + TCPP图像中减去64CuCl2图像,得到TCPP的差异荧光图像。考虑不同64CuCl2剂量的实验结果呈现剂量依赖趋势。这些结果表明,结合不同长通滤波器和减法图像处理的生物发光成像装置可以确定cr诱导的TCPP的发射光谱和差分荧光图像。结论:该方法可识别放射性核素衍生CR产生的PS荧光发射,有助于加速Cherenkov能量转移成像技术的发展和新PS的发现。
{"title":"Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters.","authors":"Winn Aung, Atsushi B Tsuji, Kazuaki Rikiyama, Fumihiko Nishikido, Satoshi Obara, Tatsuya Higashi","doi":"10.4329/wjr.v15.i11.315","DOIUrl":"10.4329/wjr.v15.i11.315","url":null,"abstract":"<p><strong>Background: </strong>Radionuclides produce Cherenkov radiation (CR), which can potentially activate photosensitizers (PSs) in phototherapy. Several groups have studied Cherenkov energy transfer to PSs using optical imaging; however, cost-effectively identifying whether PSs are excited by radionuclide-derived CR and detecting fluorescence emission from excited PSs remain a challenge. Many laboratories face the need for expensive dedicated equipment.</p><p><strong>Aim: </strong>To cost-effectively confirm whether PSs are excited by radionuclide-derived CR and distinguish fluorescence emission from excited PSs.</p><p><strong>Methods: </strong>The absorbance and fluorescence spectra of PSs were measured using a microplate reader and fluorescence spectrometer to examine the photo-physical properties of PSs. To mitigate the need for expensive dedicated equipment and achieve the aim of the study, we developed a method that utilizes a charge-coupled device optical imaging system and appropriate long-pass filters of different wavelengths (manual sequential application of long-pass filters of 515, 580, 645, 700, 750, and 800 nm). Tetrakis (4-carboxyphenyl) porphyrin (TCPP) was utilized as a model PS. Different doses of copper-64 (<sup>64</sup>CuCl<sub>2</sub>) (4, 2, and 1 mCi) were used as CR-producing radionuclides. Imaging and data acquisition were performed 0.5 h after sample preparation. Differential image analysis was conducted by using ImageJ software (National Institutes of Health) to visually evaluate TCPP fluorescence.</p><p><strong>Results: </strong>The maximum absorbance of TCPP was at 390-430 nm, and the emission peak was at 670 nm. The CR and CR-induced TCPP emissions were observed using the optical imaging system and the high-transmittance long-pass filters described above. The emission spectra of TCPP with a peak in the 645-700 nm window were obtained by calculation and subtraction based on the serial signal intensity (total flux) difference between <sup>64</sup>CuCl<sub>2</sub> + TCPP and <sup>64</sup>CuCl<sub>2</sub>. Moreover, the differential fluorescence images of TCPP were obtained by subtracting the <sup>64</sup>CuCl<sub>2</sub> image from the <sup>64</sup>CuCl<sub>2</sub> + TCPP image. The experimental results considering different <sup>64</sup>CuCl<sub>2</sub> doses showed a dose-dependent trend. These results demonstrate that a bioluminescence imaging device coupled with different long-pass filters and subtraction image processing can confirm the emission spectra and differential fluorescence images of CR-induced TCPP.</p><p><strong>Conclusion: </strong>This simple method identifies the PS fluorescence emission generated by radionuclide-derived CR and can contribute to accelerating the development of Cherenkov energy transfer imaging and the discovery of new PSs.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 11","pages":"315-323"},"PeriodicalIF":2.5,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does the use of computed tomography scenogram alone enable diagnosis in cases of bowel obstruction? 单独使用计算机断层扫描能诊断肠梗阻吗?
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-10-28 DOI: 10.4329/wjr.v15.i10.281
Ozlem Kadirhan, Volkan Kızılgoz, Sonay Aydin, Esra Bilici, Ekrem Bayat, Mecit Kantarci
<p><strong>Background: </strong>Ileus is a pathological condition of the abdomen that presents as a medical emergency. It is characterized by potential complications such as perforation and ischemia, which can lead to significant morbidity and mortality if not promptly addressed. The successful management of ileus relies heavily on the timely and precise identification of the condition. While conventional radiography (CR) is commonly used as the primary diagnostic tool, its accuracy in identifying obstructions ranges from 46% to 80%. Furthermore, the diagnostic accuracy of identifying the location and etiology of intestinal obstruction by CR is limited, therefore making computed tomography (CT) the ideal imaging modality in this regard.</p><p><strong>Aim: </strong>To determine the presence of acute bowel obstruction (BO) on abdominal CT scenogram images and the accuracy of determining its possible location, taking into account the experience of the observers.</p><p><strong>Methods: </strong>A retrospective screening was conducted on an ensemble of 46 individuals who presented to the emergency department between January 2021 and January 2022 with severe abdominal pain and were subsequently monitored for suspected ileus. The abdominal CT scans of these patients were assessed by three radiologists with varying levels of experience (1, 3, and 10 years) at different intervals (1 mo apart). The evaluation focused on determining the presence or absence of BO, as well as identifying the potential location of the obstruction (small bowel or large bowel). The study employed Kappa statistics to assess inter-observer variances, while the McNamer test was used to evaluate obstruction and segmentation discrepancies between observations. A significance level of <i>P</i> < 0.05 was determined to indicate statistical significance.</p><p><strong>Results: </strong>Out of the total sample size of 46 patients, 15 individuals (32.6%) were identified as female, while the remaining 31 individuals (67.4%) were identified as male. The ultimate diagnosis of 42 instances (91.3%) indicated ileus resulting from mechanical obstruction (MO). Among these patients, 14 (33%) experienced obstruction in the large bowel (LB), while 28 (66%) experienced obstruction in the small bowel (SB). The initial evaluation yielded sensitivity rates of 76.19%, 83.31%, and 83.33%, and diagnostic accuracy rates of 69.56%, 76.08%, and 80.43% for the detection of BO among the three observers. The initial study revealed that the average sensitivity of three observers in detecting the presence of ileus caused by MO was 80.94%, while the diagnostic accuracy was 75.35%. Based on the first evaluation, the senior observer demonstrated the highest sensitivity (85.71%), negative predictive value (92.60%), and diagnostic accuracy (80.43%) when accurately estimating the thick and thin segmentation, as per the final diagnosis. There was no statistically significant disparity observed in the sensitivities pertai
背景:肠梗阻是一种腹部病理状况,表现为医学紧急情况。它的特点是潜在的并发症,如穿孔和缺血,如果不及时处理,可导致显著的发病率和死亡率。肠梗阻的成功治疗在很大程度上依赖于病情的及时和准确的识别。虽然常规x线摄影(CR)通常被用作主要诊断工具,但其识别阻塞的准确率在46%至80%之间。此外,通过CR识别肠梗阻的位置和病因的诊断准确性有限,因此计算机断层扫描(CT)是这方面的理想成像方式。目的:结合观察者的经验,探讨急性肠梗阻(BO)在腹部CT场景图上是否存在,以及判断其可能位置的准确性。方法:对2021年1月至2022年1月期间因严重腹痛就诊于急诊科并随后监测疑似肠梗阻的46例患者进行回顾性筛查。这些患者的腹部CT扫描由三名具有不同经验水平(1年、3年和10年)的放射科医生在不同的时间间隔(间隔1个月)进行评估。评估的重点是确定BO的存在与否,以及确定梗阻的潜在位置(小肠或大肠)。本研究采用Kappa统计评估观察者间方差,采用McNamer检验评估观察间的阻塞和分割差异。以P < 0.05为差异有统计学意义。结果:在46例患者的总样本量中,女性15例(32.6%),男性31例(67.4%)。42例(91.3%)最终诊断为机械性梗阻(MO)引起的肠梗阻。其中14例(33%)发生大肠梗阻,28例(66%)发生小肠梗阻。初步评估结果显示,三名观察者对BO的敏感度分别为76.19%、83.31%和83.33%,诊断准确率分别为69.56%、76.08%和80.43%。初步研究发现,三名观察者对MO致肠梗阻的平均敏感度为80.94%,诊断准确率为75.35%。在第一次评价的基础上,根据最终诊断,高级观察员在准确估计厚分割和薄分割时灵敏度最高(85.71%),阴性预测值最高(92.60%),诊断准确率最高(80.43%)。在第二次评估中,在识别肠梗阻的敏感性上,以及在LB或SB内节段水平的精确测定上,比较第二和第三个观察者时,没有观察到统计学上的显著差异。然而,虽然第一观察者对肠梗阻的检出率没有统计学意义上的变化,但段估计的准确率明显上升(73.91%)。与其他评估者相比,高级评估者在评估肠梗阻和分割是否存在方面具有更高的准确性。结论:我们的研究结果表明,腹部CT扫描在诊断急性MO的敏感性和准确率与CR相似或更高。此外,研究表明,经验丰富的放射科医生比经验不足的放射科医生更有可能准确预测MO的存在和潜在定位。
{"title":"Does the use of computed tomography scenogram alone enable diagnosis in cases of bowel obstruction?","authors":"Ozlem Kadirhan, Volkan Kızılgoz, Sonay Aydin, Esra Bilici, Ekrem Bayat, Mecit Kantarci","doi":"10.4329/wjr.v15.i10.281","DOIUrl":"10.4329/wjr.v15.i10.281","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ileus is a pathological condition of the abdomen that presents as a medical emergency. It is characterized by potential complications such as perforation and ischemia, which can lead to significant morbidity and mortality if not promptly addressed. The successful management of ileus relies heavily on the timely and precise identification of the condition. While conventional radiography (CR) is commonly used as the primary diagnostic tool, its accuracy in identifying obstructions ranges from 46% to 80%. Furthermore, the diagnostic accuracy of identifying the location and etiology of intestinal obstruction by CR is limited, therefore making computed tomography (CT) the ideal imaging modality in this regard.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To determine the presence of acute bowel obstruction (BO) on abdominal CT scenogram images and the accuracy of determining its possible location, taking into account the experience of the observers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective screening was conducted on an ensemble of 46 individuals who presented to the emergency department between January 2021 and January 2022 with severe abdominal pain and were subsequently monitored for suspected ileus. The abdominal CT scans of these patients were assessed by three radiologists with varying levels of experience (1, 3, and 10 years) at different intervals (1 mo apart). The evaluation focused on determining the presence or absence of BO, as well as identifying the potential location of the obstruction (small bowel or large bowel). The study employed Kappa statistics to assess inter-observer variances, while the McNamer test was used to evaluate obstruction and segmentation discrepancies between observations. A significance level of &lt;i&gt;P&lt;/i&gt; &lt; 0.05 was determined to indicate statistical significance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Out of the total sample size of 46 patients, 15 individuals (32.6%) were identified as female, while the remaining 31 individuals (67.4%) were identified as male. The ultimate diagnosis of 42 instances (91.3%) indicated ileus resulting from mechanical obstruction (MO). Among these patients, 14 (33%) experienced obstruction in the large bowel (LB), while 28 (66%) experienced obstruction in the small bowel (SB). The initial evaluation yielded sensitivity rates of 76.19%, 83.31%, and 83.33%, and diagnostic accuracy rates of 69.56%, 76.08%, and 80.43% for the detection of BO among the three observers. The initial study revealed that the average sensitivity of three observers in detecting the presence of ileus caused by MO was 80.94%, while the diagnostic accuracy was 75.35%. Based on the first evaluation, the senior observer demonstrated the highest sensitivity (85.71%), negative predictive value (92.60%), and diagnostic accuracy (80.43%) when accurately estimating the thick and thin segmentation, as per the final diagnosis. There was no statistically significant disparity observed in the sensitivities pertai","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 10","pages":"281-292"},"PeriodicalIF":2.5,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-point Dixon and six-point Dixon magnetic resonance techniques in the detection, quantification and grading of hepatic steatosis. 两点Dixon和六点Dixon磁共振技术在肝脂肪变性的检测、定量和分级中的应用。
IF 2.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-10-28 DOI: 10.4329/wjr.v15.i10.293
Mohamed Elfaal, Alanna Supersad, Craig Ferguson, Stephanie Locas, Florin Manolea, Mitchell P Wilson, Medica Sam, Wendy Tu, Gavin Low

Background: Hepatic steatosis is a very common problem worldwide.

Aim: To assess the performance of two- and six-point Dixon magnetic resonance (MR) techniques in the detection, quantification and grading of hepatic steatosis.

Methods: A single-center retrospective study was performed in 62 patients with suspected parenchymal liver disease. MR sequences included two-point Dixon, six-point Dixon, MR spectroscopy (MRS) and MR elastography. Fat fraction (FF) estimates on the Dixon techniques were compared to the MRS-proton density FF (PDFF). Statistical tests used included Pearson's correlation and receiver operating characteristic.

Results: FF estimates on the Dixon techniques showed excellent correlation (≥ 0.95) with MRS-PDFF, and excellent accuracy [area under the receiver operating characteristic (AUROC) ≥ 0.95] in: (1) Detecting steatosis; and (2) Grading severe steatosis, (P < 0.001). In iron overload, two-point Dixon was not evaluable due to confounding T2* effects. FF estimates on six-point Dixon vs MRS-PDFF showed a moderate correlation (0.82) in iron overload vs an excellent correlation (0.97) without iron overload, (P < 0.03). The accuracy of six-point Dixon in grading mild steatosis improved (AUROC: 0.59 to 0.99) when iron overload cases were excluded. The excellent correlation (> 0.9) between the Dixon techniques vs MRS-PDFF did not change in the presence of liver fibrosis (P < 0.01).

Conclusion: Dixon techniques performed satisfactorily for the evaluation of hepatic steatosis but with exceptions.

背景:肝脂肪变性是世界范围内非常普遍的问题。目的:评价二点和六点迪克森磁共振(MR)技术在肝脂肪变性的检测、定量和分级中的应用价值。方法:对62例疑似实质性肝病患者进行单中心回顾性研究。MR序列包括两点Dixon、六点Dixon、MR光谱(MRS)和MR弹性成像。将Dixon技术估计的脂肪分数(FF)与mrs质子密度FF (PDFF)进行比较。使用的统计检验包括皮尔逊相关和接受者工作特征。结果:Dixon技术的FF估计值与MRS-PDFF具有良好的相关性(≥0.95),并且在以下方面具有良好的准确性[受试者工作特征下面积(AUROC)≥0.95]:(1)检测脂肪变性;(2)重度脂肪变性分级(P < 0.001)。在铁超载时,由于混淆T2*效应,两点Dixon不能评估。6点Dixon与MRS-PDFF的FF估计显示,铁超载的中度相关性(0.82)与无铁超载的极好相关性(0.97)(P < 0.03)。当排除铁超载病例时,6点Dixon分级轻度脂肪变性的准确性提高(AUROC: 0.59至0.99)。Dixon技术与MRS-PDFF之间的极好相关性(> 0.9)在肝纤维化存在时没有改变(P < 0.01)。结论:Dixon技术对肝脂肪变性的评价令人满意,但也有例外。
{"title":"Two-point Dixon and six-point Dixon magnetic resonance techniques in the detection, quantification and grading of hepatic steatosis.","authors":"Mohamed Elfaal, Alanna Supersad, Craig Ferguson, Stephanie Locas, Florin Manolea, Mitchell P Wilson, Medica Sam, Wendy Tu, Gavin Low","doi":"10.4329/wjr.v15.i10.293","DOIUrl":"https://doi.org/10.4329/wjr.v15.i10.293","url":null,"abstract":"<p><strong>Background: </strong>Hepatic steatosis is a very common problem worldwide.</p><p><strong>Aim: </strong>To assess the performance of two- and six-point Dixon magnetic resonance (MR) techniques in the detection, quantification and grading of hepatic steatosis.</p><p><strong>Methods: </strong>A single-center retrospective study was performed in 62 patients with suspected parenchymal liver disease. MR sequences included two-point Dixon, six-point Dixon, MR spectroscopy (MRS) and MR elastography. Fat fraction (FF) estimates on the Dixon techniques were compared to the MRS-proton density FF (PDFF). Statistical tests used included Pearson's correlation and receiver operating characteristic.</p><p><strong>Results: </strong>FF estimates on the Dixon techniques showed excellent correlation (≥ 0.95) with MRS-PDFF, and excellent accuracy [area under the receiver operating characteristic (AUROC) ≥ 0.95] in: (1) Detecting steatosis; and (2) Grading severe steatosis, (<i>P</i> < 0.001). In iron overload, two-point Dixon was not evaluable due to confounding T2* effects. FF estimates on six-point Dixon <i>vs</i> MRS-PDFF showed a moderate correlation (0.82) in iron overload <i>vs</i> an excellent correlation (0.97) without iron overload, (<i>P</i> < 0.03). The accuracy of six-point Dixon in grading mild steatosis improved (AUROC: 0.59 to 0.99) when iron overload cases were excluded. The excellent correlation (> 0.9) between the Dixon techniques <i>vs</i> MRS-PDFF did not change in the presence of liver fibrosis (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Dixon techniques performed satisfactorily for the evaluation of hepatic steatosis but with exceptions.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 10","pages":"293-303"},"PeriodicalIF":2.5,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
World journal of radiology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1