Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20251017-00413
Y Wei, Y J Wu, J J Deng, W Y Yu, Z T Chen, Y Fan, M M Xu, Q Yuan, C C Zhou, Z J Shang, L L Chen, X D Zhou, X L Deng
In recent years, artificial intelligence (AI) has rapidly advanced in the field of oral medicine, with applications extending across disease screening, diagnosis assistance, treatment planning, prognosis prediction, and dental education. Powered by deep learning and multimodal analytics, AI can efficiently integrate data from cone beam CT, intraoral scans, and electronic health records, enhancing precision and efficiency in managing dental caries, endodontic and periodontal diseases, oral mucosal lesions, and maxillofacial trauma. AI also contributes to omics research, biomaterial development, and laboratory automation, accelerating translational progress from basic science to clinical practice. Despite these advances, challenges such as lack of standardized data governance, limited model interpretability, privacy and security risks, and insufficient clinical validation and regulatory frameworks still remain. This expert consensus provides a comprehensive overview of AI applications in dentistry, outlines core technical pathways, and proposes recommendations related to data governance, platform development, ethics, and regulatory requirements. It aims to provide practical and unified guidance for dental practitioners, healthcare institutions, researchers, and industry stakeholders, promoting safe, standardized, and sustainable development of AI in oral healthcare.
{"title":"[Expert consensus on the application of artificial intelligence in stomatology].","authors":"Y Wei, Y J Wu, J J Deng, W Y Yu, Z T Chen, Y Fan, M M Xu, Q Yuan, C C Zhou, Z J Shang, L L Chen, X D Zhou, X L Deng","doi":"10.3760/cma.j.cn112144-20251017-00413","DOIUrl":"10.3760/cma.j.cn112144-20251017-00413","url":null,"abstract":"<p><p>In recent years, artificial intelligence (AI) has rapidly advanced in the field of oral medicine, with applications extending across disease screening, diagnosis assistance, treatment planning, prognosis prediction, and dental education. Powered by deep learning and multimodal analytics, AI can efficiently integrate data from cone beam CT, intraoral scans, and electronic health records, enhancing precision and efficiency in managing dental caries, endodontic and periodontal diseases, oral mucosal lesions, and maxillofacial trauma. AI also contributes to omics research, biomaterial development, and laboratory automation, accelerating translational progress from basic science to clinical practice. Despite these advances, challenges such as lack of standardized data governance, limited model interpretability, privacy and security risks, and insufficient clinical validation and regulatory frameworks still remain. This expert consensus provides a comprehensive overview of AI applications in dentistry, outlines core technical pathways, and proposes recommendations related to data governance, platform development, ethics, and regulatory requirements. It aims to provide practical and unified guidance for dental practitioners, healthcare institutions, researchers, and industry stakeholders, promoting safe, standardized, and sustainable development of AI in oral healthcare.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"151-161"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20260105-00005
J Zhou, X Y Gu, S L Wang
To explore how specialized medical museums can break through homogenization on exhibition and construct Chinese narratives within the modern medical system, this study takes the International Museum of Stomatology, the West China Museum of Stomatology (formerly the Museum of Chinese Stomatology), and the Museum of the History of Chinese Stomatology as research objects to examine their exhibition construction and narrative practices based on field investigations, interviews, and document analysis. The study finds that, relying on disciplinary traditions and accumulated research resources, the three museums have formed three distinctive development models: internationalized collections focusing on contemporary disciplinary history, generative collections originating from teaching and clinical practices, and interpretive collections driven by interdisciplinary researches. At the narrative level, by embedding Chinese stomatological practice within global disciplinary lineages, national historical processes, and dialogues between ancient and modern medical knowledge, these museums avoid an interpretive framework based on a binary opposition between China and the West, and effectively present the contributions of Chinese stomatology within the global system of modern medicine. The construction of stomatology museums reflects the disciplinary self-awareness of the stomatological community in deeply integrating medical humanities and disciplinary history education into professional training, and has also become an important driving force for the development of related museums and the innovation of their narratives.
{"title":"[Construction of distinctive exhibitions and narrative innovation in specialized medical museums: an analysis based on the construction practices of three dental museums].","authors":"J Zhou, X Y Gu, S L Wang","doi":"10.3760/cma.j.cn112144-20260105-00005","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20260105-00005","url":null,"abstract":"<p><p>To explore how specialized medical museums can break through homogenization on exhibition and construct Chinese narratives within the modern medical system, this study takes the International Museum of Stomatology, the West China Museum of Stomatology (formerly the Museum of Chinese Stomatology), and the Museum of the History of Chinese Stomatology as research objects to examine their exhibition construction and narrative practices based on field investigations, interviews, and document analysis. The study finds that, relying on disciplinary traditions and accumulated research resources, the three museums have formed three distinctive development models: internationalized collections focusing on contemporary disciplinary history, generative collections originating from teaching and clinical practices, and interpretive collections driven by interdisciplinary researches. At the narrative level, by embedding Chinese stomatological practice within global disciplinary lineages, national historical processes, and dialogues between ancient and modern medical knowledge, these museums avoid an interpretive framework based on a binary opposition between China and the West, and effectively present the contributions of Chinese stomatology within the global system of modern medicine. The construction of stomatology museums reflects the disciplinary self-awareness of the stomatological community in deeply integrating medical humanities and disciplinary history education into professional training, and has also become an important driving force for the development of related museums and the innovation of their narratives.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"172-178"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20251201-00478
Y H Shan, Y S Zhou, Q Chen, D Q Zhang, C B Guo
Since the introduction of modern Western medicine to China, Chinese medical education, including dental education, had undergone profound changes, gradually shifting from the traditional family inheritance or apprenticeship model to the modern medical school education system. Chinese dentists actively engaged in educational practice, and successively established 8 dental schools during modern times (1909-1949). Among them, Shanghai Dental College, as the only institution successfully registered with the education department and continued to operate after the founding of People's Republic of China, held a special historical position. Currently, systematic research on the background and process of its establishment is still insufficient. This article reviews the background of the establishment and development process of Shanghai Dental College, focusing on the school construction process, facilities, course system, teachers and student training, to better understand the efforts of modern Chinese dentists in promoting dental education, and enrich the historical research of stomatology.
{"title":"[A historical review of Shanghai Dental College].","authors":"Y H Shan, Y S Zhou, Q Chen, D Q Zhang, C B Guo","doi":"10.3760/cma.j.cn112144-20251201-00478","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20251201-00478","url":null,"abstract":"<p><p>Since the introduction of modern Western medicine to China, Chinese medical education, including dental education, had undergone profound changes, gradually shifting from the traditional family inheritance or apprenticeship model to the modern medical school education system. Chinese dentists actively engaged in educational practice, and successively established 8 dental schools during modern times (1909-1949). Among them, Shanghai Dental College, as the only institution successfully registered with the education department and continued to operate after the founding of People's Republic of China, held a special historical position. Currently, systematic research on the background and process of its establishment is still insufficient. This article reviews the background of the establishment and development process of Shanghai Dental College, focusing on the school construction process, facilities, course system, teachers and student training, to better understand the efforts of modern Chinese dentists in promoting dental education, and enrich the historical research of stomatology.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"209-213"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20250624-00233
X H Wang, Z Wang, N Zhao, L N Wei, K Q Yang
Oral cancer is a highly prevalent malignant tumor of the head and neck region worldwide. Patients often experience body image distress due to visible facial scarring and oral dysfunction. The advancement of smart healthcare technologies has provided innovative intervention strategies for body image rehabilitation in oral cancer patients. This study reviews and synthesizes global literature to systematically analyze the types, applications, and recommendations of body image intervention strategies for oral cancer patients in the context of smart healthcare. Current limitations and future directions are discussed.with the aim of supporting smart rehabilitation for patients and offering insights for the digital transformation of oral health care.
{"title":"[Advances in the application of body image intervention strategies for oral cancer patients under smart healthcare].","authors":"X H Wang, Z Wang, N Zhao, L N Wei, K Q Yang","doi":"10.3760/cma.j.cn112144-20250624-00233","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250624-00233","url":null,"abstract":"<p><p>Oral cancer is a highly prevalent malignant tumor of the head and neck region worldwide. Patients often experience body image distress due to visible facial scarring and oral dysfunction. The advancement of smart healthcare technologies has provided innovative intervention strategies for body image rehabilitation in oral cancer patients. This study reviews and synthesizes global literature to systematically analyze the types, applications, and recommendations of body image intervention strategies for oral cancer patients in the context of smart healthcare. Current limitations and future directions are discussed.with the aim of supporting smart rehabilitation for patients and offering insights for the digital transformation of oral health care.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"281-285"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20250609-00213
C B Li, S Q Bao, R Zhang, H K Luo, M S Si
Objective: To analyze the current status, trends and research hotspots of clinical research on oral implantology published in international journals by scholars from China(excluding Hong Kong, Macao, and Taiwan), and to provide insights into research dynamics for scholars and institutions in related fields. Methods: Based on Web of Science Core Collection, 460 documents were screened. Bibliometric analysis was performed using CiteSpace, and institutional collaboration network, keyword co-occurrence mapping and time zone view of burst words were drawn to explore the characteristics of publications, research hotspots and frontiers. Results: The number of Chinese oral implantology clinical research publications increased year by year, and institutions such as Peking University and Shanghai Jiao Tong University were the core contributors. Research hotspots focus on bone augmentation techniques (e.g., bone regeneration, maxillary sinus lift) and immediate implantation, and the frontier direction is dynamic navigation and robot-assisted surgery. The research areas are mainly in dentistry and oral surgery, with notable interdisciplinary integration. The percentage of high-impact journals was significant. Conclusions: The bibliometric study visualized the hotspots of clinical research in the field of oral implantation published by Chinese scholars in international journals. Future efforts should focus on improving the evidence system by large-sample multicenter studies and strengthen the collaboration between teams to promote the development of the discipline.
目的:分析中国(不含港澳台地区)学者在国际期刊上发表的口腔种植临床研究现状、趋势及研究热点,为相关领域的学者和机构了解研究动态提供参考。方法:基于Web of Science核心馆藏,筛选460篇文献。利用CiteSpace进行文献计量分析,绘制机构协作网络、关键词共现图和突发词时区视图,探索出版物特征、研究热点和前沿。结果:我国口腔种植临床研究论文数量逐年增加,以北京大学、上海交通大学等院校为主。研究热点集中在骨增强技术(如骨再生、上颌窦提升)和即刻种植,前沿方向是动态导航和机器人辅助手术。研究领域以牙科和口腔外科为主,跨学科融合显著。高影响力期刊的比例非常显著。结论:文献计量学研究可视化了我国学者在国际期刊上发表的口腔种植领域临床研究热点。今后应注重通过大样本多中心研究完善证据体系,加强团队合作,促进学科发展。
{"title":"[International publication trends and hotspots of clinical oral implantology research in China].","authors":"C B Li, S Q Bao, R Zhang, H K Luo, M S Si","doi":"10.3760/cma.j.cn112144-20250609-00213","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250609-00213","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the current status, trends and research hotspots of clinical research on oral implantology published in international journals by scholars from China(excluding Hong Kong, Macao, and Taiwan), and to provide insights into research dynamics for scholars and institutions in related fields. <b>Methods:</b> Based on Web of Science Core Collection, 460 documents were screened. Bibliometric analysis was performed using CiteSpace, and institutional collaboration network, keyword co-occurrence mapping and time zone view of burst words were drawn to explore the characteristics of publications, research hotspots and frontiers. <b>Results:</b> The number of Chinese oral implantology clinical research publications increased year by year, and institutions such as Peking University and Shanghai Jiao Tong University were the core contributors. Research hotspots focus on bone augmentation techniques (e.g., bone regeneration, maxillary sinus lift) and immediate implantation, and the frontier direction is dynamic navigation and robot-assisted surgery. The research areas are mainly in dentistry and oral surgery, with notable interdisciplinary integration. The percentage of high-impact journals was significant. <b>Conclusions:</b> The bibliometric study visualized the hotspots of clinical research in the field of oral implantation published by Chinese scholars in international journals. Future efforts should focus on improving the evidence system by large-sample multicenter studies and strengthen the collaboration between teams to promote the development of the discipline.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"220-228"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20250930-00387
T R Tian, X X Cai, Y Man
Augmented reality (AR) technology has the potential to fundamentally address the hand-eye coordination challenges inherent in dental navigation systems, and further, to revolutionize the way surgeons perceive and process clinical information during surgical procedures. However, current AR applications remain largely confined to simple interactions with imaging data, with little evidence of domain-specific hardware or generalized AR paradigms. More importantly, there is still a lack of discussion on how surgeons cognitively interpret AR-based virtual information. This gap has hindered efforts to design AR applications that are aligned with surgical cognitive processes, thereby limiting the full clinical value of AR in oral implant surgery. This paper reviews recent developments in AR across relevant disciplines, attempts to classify the underlying logic of AR interaction, and drawing on our team's research and development over the past several years, proposes a technical paradigm for AR applications with the potential for large-scale clinical adoption. The paradigm is based on a 'spatially anchored virtual indicators' that binds purely virtual guidance cues directly to the surgical field, enabling an intuitive, low-cognitive-load, and clinically scalable form of intraoperative navigation beyond conventional model-based AR approaches.
{"title":"[Principles and paradigms of augmented reality in oral implant surgery].","authors":"T R Tian, X X Cai, Y Man","doi":"10.3760/cma.j.cn112144-20250930-00387","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250930-00387","url":null,"abstract":"<p><p>Augmented reality (AR) technology has the potential to fundamentally address the hand-eye coordination challenges inherent in dental navigation systems, and further, to revolutionize the way surgeons perceive and process clinical information during surgical procedures. However, current AR applications remain largely confined to simple interactions with imaging data, with little evidence of domain-specific hardware or generalized AR paradigms. More importantly, there is still a lack of discussion on how surgeons cognitively interpret AR-based virtual information. This gap has hindered efforts to design AR applications that are aligned with surgical cognitive processes, thereby limiting the full clinical value of AR in oral implant surgery. This paper reviews recent developments in AR across relevant disciplines, attempts to classify the underlying logic of AR interaction, and drawing on our team's research and development over the past several years, proposes a technical paradigm for AR applications with the potential for large-scale clinical adoption. The paradigm is based on a 'spatially anchored virtual indicators' that binds purely virtual guidance cues directly to the surgical field, enabling an intuitive, low-cognitive-load, and clinically scalable form of intraoperative navigation beyond conventional model-based AR approaches.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"162-171"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20250807-00306
J L Chen, Y Yan, J R Li, T T Lan, W W Ma
Orthodontically induced inflammatory root resorption (OIIRR) is one of the most common and troublesome complications in orthodontic treatment, which not only affects the long-term stability of teeth, but also can cause irreversible damage to the patient's oral health. In light of the rising demand for orthodontic treatment, the prevention and treatment of OIIRR has become a primary focus for clinicians and researchers. Recent multidisciplinary studies have revealed the complex regulatory network of OIIRR, including mechanical signal transduction, immune microenvironment remodelling, cell differentiation pattern transformation and hard tissue matrix-specific regulation. Concurrently, targeted intervention strategies that have been developed based on these mechanisms have demonstrated favourable clinical application prospects. The present article systematically reviewed the clinical characteristics, influencing factors, molecular mechanisms and the latest clinical intervention strategies of OIIRR.
{"title":"[Research status and prospect of orthodontically induced inflammatory root resorption].","authors":"J L Chen, Y Yan, J R Li, T T Lan, W W Ma","doi":"10.3760/cma.j.cn112144-20250807-00306","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250807-00306","url":null,"abstract":"<p><p>Orthodontically induced inflammatory root resorption (OIIRR) is one of the most common and troublesome complications in orthodontic treatment, which not only affects the long-term stability of teeth, but also can cause irreversible damage to the patient's oral health. In light of the rising demand for orthodontic treatment, the prevention and treatment of OIIRR has become a primary focus for clinicians and researchers. Recent multidisciplinary studies have revealed the complex regulatory network of OIIRR, including mechanical signal transduction, immune microenvironment remodelling, cell differentiation pattern transformation and hard tissue matrix-specific regulation. Concurrently, targeted intervention strategies that have been developed based on these mechanisms have demonstrated favourable clinical application prospects. The present article systematically reviewed the clinical characteristics, influencing factors, molecular mechanisms and the latest clinical intervention strategies of OIIRR.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"273-280"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20251205-00489
G Li, Z Y Yang, L Tian, G W Li, Q Zhou, Y J Xu, J Zhou, F L Chen, X D Zhou
This article reviews the history of the treatment of oral and maxillofacial injuries during the War to Resist US Aggression and Aid Korea from three aspects: dental medical services in the Korean battlefield, oral and maxillofacial plastic surgery in the rear treatment bases in Northeast China, and oral medical services in rear bases across the country. It shows that Chinese dentists were not afraid of sacrifice or difficulties, and had contributed their lives and wisdom to the oral health of Chinese and Korean military and civilians during the War to Resist US Aggression and Aid Korea, as well as to the cause of world peace. Their spirit is the traditions of revolution of the development of China's dental medicine industry.
{"title":"[Chinese dentists in the War to Resist US Aggression and Aid Korea].","authors":"G Li, Z Y Yang, L Tian, G W Li, Q Zhou, Y J Xu, J Zhou, F L Chen, X D Zhou","doi":"10.3760/cma.j.cn112144-20251205-00489","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20251205-00489","url":null,"abstract":"<p><p>This article reviews the history of the treatment of oral and maxillofacial injuries during the War to Resist US Aggression and Aid Korea from three aspects: dental medical services in the Korean battlefield, oral and maxillofacial plastic surgery in the rear treatment bases in Northeast China, and oral medical services in rear bases across the country. It shows that Chinese dentists were not afraid of sacrifice or difficulties, and had contributed their lives and wisdom to the oral health of Chinese and Korean military and civilians during the War to Resist US Aggression and Aid Korea, as well as to the cause of world peace. Their spirit is the traditions of revolution of the development of China's dental medicine industry.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"214-219"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20250923-00375
Y X Lin, S Q Wang, Y Z Lai, J J Su
<p><p><b>Objective:</b> To determine an optimal surface modification protocol for carbon fiber-reinforced polyether ether ketone (CFR-PEEK), this study investigated the enhancement of material bioactivity and osteogenic properties. This was achieved by constructing a porous structure via sulfonation and polydopamine (PDA) modification and subsequently grafting osteogenic growth peptides (OGP) onto the surface. <b>Methods:</b> Using CFR-PEEK as the control group, CFR-PEEK specimens were sequentially subjected to 6 minute of sulfonation, hydrothermal treatment (SPK group), and PDA modification (SPD group), followed by grafting with 25, 50, or 100 μg/ml OGP (SPO25, SPO50, SPO100 groups). Surface morphology, functional groups, elemental composition, and hydrophilicity of each test specimen group were analyzed using scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and contact angle testing. Mouse osteoprogenitor cells (MC3T3-E1) were cultured on the surfaces of each group. Cell adhesion, proliferation, and osteogenic differentiation capabilities were evaluated through cell proliferation assays, immunofluorescence staining, alkaline phosphatase (ALP) and alizarin red staining, quantitative analysis, and real-time fluorescence quantitative PCR (RT-qPCR). <b>Results:</b> SEM revealed that the surface of the specimens formed a uniform three-dimensional porous structure after sulfonation treatment. ATR-FTIR and XPS revealed distinct characteristic peaks in the SPD and SPO groups; contact angle measurements demonstrated significantly superior hydrophilicity in all SPO groups compared to CFR-PEEK and SPK, with SPO50 group exhibiting optimal hydrophilicity (surface contact angle: 35.3°±2.5°), showing statistically significant differences from other groups (all <i>P</i><0.05). Cell proliferation assays demonstrated no cytotoxicity in the SPK, SPD, and SPO groups, with all significantly promoting cell proliferation (compared to CFR-PEEK). Among these, the SPO50 group exhibited significantly higher cell proliferation (1.365±0.049) on day 5 than other groups (<i>P</i><0.05), showing the best efficacy. SPK and SPD groups exhibited good cell spreading, while SPO groups (especially SPO50 and SPO100) demonstrated optimal cell adhesion properties. ALP staining and alizarin red staining results, along with their quantitative analysis, revealed that the SPO50 group exhibited the deepest ALP staining at both 7 and 14 d of osteogenic induction, and also demonstrated the deepest alizarin red staining at 14 days. Correspondingly, its 14-day ALP activity (0.057±0.001) and alizarin red quantitative value (0.246±0.006) were significantly higher than those of other groups (all <i>P</i><0.05), indicating that the SPO50 group exhibited the optimal <i>in vitro</i> osteogenic differentiation-promoting performance. RT-qPCR revealed that all SPO groups exhibited significantly hi
{"title":"[<i>In vitro</i> study on the osteogenic potential of sulfonated and osteogenic growth peptide co-modified carbon fiber-reinforced polyetheretherketone].","authors":"Y X Lin, S Q Wang, Y Z Lai, J J Su","doi":"10.3760/cma.j.cn112144-20250923-00375","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250923-00375","url":null,"abstract":"<p><p><b>Objective:</b> To determine an optimal surface modification protocol for carbon fiber-reinforced polyether ether ketone (CFR-PEEK), this study investigated the enhancement of material bioactivity and osteogenic properties. This was achieved by constructing a porous structure via sulfonation and polydopamine (PDA) modification and subsequently grafting osteogenic growth peptides (OGP) onto the surface. <b>Methods:</b> Using CFR-PEEK as the control group, CFR-PEEK specimens were sequentially subjected to 6 minute of sulfonation, hydrothermal treatment (SPK group), and PDA modification (SPD group), followed by grafting with 25, 50, or 100 μg/ml OGP (SPO25, SPO50, SPO100 groups). Surface morphology, functional groups, elemental composition, and hydrophilicity of each test specimen group were analyzed using scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and contact angle testing. Mouse osteoprogenitor cells (MC3T3-E1) were cultured on the surfaces of each group. Cell adhesion, proliferation, and osteogenic differentiation capabilities were evaluated through cell proliferation assays, immunofluorescence staining, alkaline phosphatase (ALP) and alizarin red staining, quantitative analysis, and real-time fluorescence quantitative PCR (RT-qPCR). <b>Results:</b> SEM revealed that the surface of the specimens formed a uniform three-dimensional porous structure after sulfonation treatment. ATR-FTIR and XPS revealed distinct characteristic peaks in the SPD and SPO groups; contact angle measurements demonstrated significantly superior hydrophilicity in all SPO groups compared to CFR-PEEK and SPK, with SPO50 group exhibiting optimal hydrophilicity (surface contact angle: 35.3°±2.5°), showing statistically significant differences from other groups (all <i>P</i><0.05). Cell proliferation assays demonstrated no cytotoxicity in the SPK, SPD, and SPO groups, with all significantly promoting cell proliferation (compared to CFR-PEEK). Among these, the SPO50 group exhibited significantly higher cell proliferation (1.365±0.049) on day 5 than other groups (<i>P</i><0.05), showing the best efficacy. SPK and SPD groups exhibited good cell spreading, while SPO groups (especially SPO50 and SPO100) demonstrated optimal cell adhesion properties. ALP staining and alizarin red staining results, along with their quantitative analysis, revealed that the SPO50 group exhibited the deepest ALP staining at both 7 and 14 d of osteogenic induction, and also demonstrated the deepest alizarin red staining at 14 days. Correspondingly, its 14-day ALP activity (0.057±0.001) and alizarin red quantitative value (0.246±0.006) were significantly higher than those of other groups (all <i>P</i><0.05), indicating that the SPO50 group exhibited the optimal <i>in vitro</i> osteogenic differentiation-promoting performance. RT-qPCR revealed that all SPO groups exhibited significantly hi","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"239-250"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.3760/cma.j.cn112144-20250914-00362
X Y Gu, Y F Zhu, J Zhou
Pierre Fauchard is frequently cited in textbooks and monographs on the history of dentistry and is widely recognized for his significant role in the development of early modern dental practice. However, existing studies tend to focus on his personal anecdotes or specific technical innovations, and have yet to address the fundamental question on why Fauchard has received such scholarly appraisal from the broader perspective of dental history. Drawing on Fauchard's biography, his seminal work The Surgeon Dentist, or Treatise on the Teeth, and interactions with the scholarly community of his time, this study systematically analyzes his key contributions to dental theory, clinical practice, and the formation of professional dental identity. This research helps fill a gap in Chinese-language scholarship and provides useful insights for the study of dental history and medical humanities education.
{"title":"[Pierre Fauchard's life and his contributions to the professionalization of dentistry].","authors":"X Y Gu, Y F Zhu, J Zhou","doi":"10.3760/cma.j.cn112144-20250914-00362","DOIUrl":"https://doi.org/10.3760/cma.j.cn112144-20250914-00362","url":null,"abstract":"<p><p>Pierre Fauchard is frequently cited in textbooks and monographs on the history of dentistry and is widely recognized for his significant role in the development of early modern dental practice. However, existing studies tend to focus on his personal anecdotes or specific technical innovations, and have yet to address the fundamental question on why Fauchard has received such scholarly appraisal from the broader perspective of dental history. Drawing on Fauchard's biography, his seminal work <i>The Surgeon Dentist, or Treatise on the Teeth</i>, and interactions with the scholarly community of his time, this study systematically analyzes his key contributions to dental theory, clinical practice, and the formation of professional dental identity. This research helps fill a gap in Chinese-language scholarship and provides useful insights for the study of dental history and medical humanities education.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 2","pages":"186-191"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}