Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.270
Anton Mohylnyk, Serhii Suprunenko
The overloading of emergency services is an urgent public health problem that affects all countries of the world, and despite numerous efforts in this field, significant progress has not yet been achieved. Against the background of the military invasion of muscovites to the territory of Ukraine with constant air attacks on cities with a high population density, the load on the emergency medical service has increased many times, which requires the fastest possible improvement of its structure and work organization. The one of the important factors driving the increase patient admissions to emergency departments is often non-urgent calls or visits, that is, visits by patients with conditions that do not require urgent attention or complex medical interventions and can be safely treated by primary medical aid. The consequences of overloading the emergency medical service negatively affect patients and medical personnel. So, low medical care quality leads to mortality among the patients, the numerous of medical errors and financial costs, and there is "burnout" of medical staff. The key to success is the correct organization of medical triage. Some countries have their own system of medical triage, although it is not different fundamentally. In the triage process, there are three options for evaluating the decision on the urgency category of assistance: expected result, excessive level or undersorting. Resource overspending occurs when the assigned triage category has a higher level of urgency than necessary. This so-called medical re-sorting is a reassessment of the severity of an illness or injury. Despite the progressively increasing load on the emergency medical service in Ukraine against the background of the moscow invasion and the increase in its funding in recent years, only a quantitative indicators of its work have significantly increased without much improvement in the quality of care due to absent of the any changes in the organization of the work of the emergency service which is based on outdated Soviet management principles.
{"title":"PRINCIPLES OF MEDICAL TRIAGE FOR PATIENTS IN UKRAINE AND ABROAD","authors":"Anton Mohylnyk, Serhii Suprunenko","doi":"10.31718/2077-1096.24.1.270","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.270","url":null,"abstract":"The overloading of emergency services is an urgent public health problem that affects all countries of the world, and despite numerous efforts in this field, significant progress has not yet been achieved. Against the background of the military invasion of muscovites to the territory of Ukraine with constant air attacks on cities with a high population density, the load on the emergency medical service has increased many times, which requires the fastest possible improvement of its structure and work organization. The one of the important factors driving the increase patient admissions to emergency departments is often non-urgent calls or visits, that is, visits by patients with conditions that do not require urgent attention or complex medical interventions and can be safely treated by primary medical aid. The consequences of overloading the emergency medical service negatively affect patients and medical personnel. So, low medical care quality leads to mortality among the patients, the numerous of medical errors and financial costs, and there is \"burnout\" of medical staff. The key to success is the correct organization of medical triage. Some countries have their own system of medical triage, although it is not different fundamentally. In the triage process, there are three options for evaluating the decision on the urgency category of assistance: expected result, excessive level or undersorting. Resource overspending occurs when the assigned triage category has a higher level of urgency than necessary. This so-called medical re-sorting is a reassessment of the severity of an illness or injury. Despite the progressively increasing load on the emergency medical service in Ukraine against the background of the moscow invasion and the increase in its funding in recent years, only a quantitative indicators of its work have significantly increased without much improvement in the quality of care due to absent of the any changes in the organization of the work of the emergency service which is based on outdated Soviet management principles.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.78
Yu. A. Bezhuk, O. Martovlos (Hodovana)
The study of pharmacotherapeutic (immunomodulating) action in conditions of in vitro cell cultures is currently considered appropriate and justified for determining the action of drugs at the preclinical level. It is also important to address the pathogenetic nature in using such agents, especially fro local application. This study investigated the efficacy of a multicomponent gel containing decamethoxine and hyaluronic acid in treating chronic catarrhal gingivitis among patients with chronic tonsillitis. The purpose of the work is to assess the efficacy of a gel containing decamethoxine and hyaluronic acid on the tissue of the palatine tonsils in the therapy of chronic catarrhal gingivitis in patients with chronic tonsillitis. Materials and methods. To investigate the effects of the main active components in the gel, we followed the recommendations of I.P. Kaidashev et al. for testing pharmacological preparations in in vitro cultures. Tissue samples from the palatine tonsils were obtained from 20 patients with chronic tonsillitis and chronic catarrhal gingivitis undergoing tonsillectomy. All procedures adhered to the guidelines set by the Laboratory of Pathophysiology and Immunology at Prof. O.S. Kolomiichenko Institute of Otolaryngology, National Academy of Sciences of Ukraine. Palatine tonsil tissue was incubated in 199 medium (Serva, Germany) containing gentamicin sulfate (Darnytsa, Ukraine) at a concentration of 120 μg/ml for 20 minutes at 4-8°C. After that, the hemorrhagic parts were removed from the whole tonsil and placed into Eagle's medium (Sigma, USA) and rinsed three to four times. Subsequently, the prepared tissue was placed in sterile vials containing enriched Eagle's medium supplemented with L-glutamine, sodium bicarbonate, 100x vitamin concentrate, 5% fetal calf serum, and 60 μg/mL gentamicin. Tonsil tissue was dissected using scissors and then washed repeatedly (5-7 times) with fresh medium to remove loosely attached cells, then, the resulting cell suspension was filtered. All procedures were conducted within a sterile laminar flow cabinet. Cell viability was assessed using light microscopy (Olympus-23, Japan) and a hemocytometer. A final cell suspension containing 2.5 million lymphocytes per milliliter of medium was prepared. Suspensions with a viability of less than 90% (blue, "dead" cells) were excluded from further experiments. Results. Treatment of in vitro palatine tonsil cells from patients with chronic catarrhal gingivitis and recurrent tonsillitis with the main components of the developed gel (decamethoxine and hyaluronic acid) did not induce significant changes in the concentration of α and γ-interferons. Our findings suggest that the gel composition reduces the levels of pro-inflammatory factors: interleukin-1β and immune complexes. Additionally, it appears to stimulate the production of the antimicrobial factor antistreptolysin-O by tonsil cells, potentially leading to increased antibody production against hemolytic
{"title":"IMPACT OF A GEL COMPOSITION CONTAINING VARIOUS SUBSTANCES ON INDICES OF IMMUNITY AND TISSUE INFLAMMATION IN PALATINE TONSILS OF PATIENTS WITH CATARRHAL GINGIVITIS DURING CHRONIC TONSILLITIS","authors":"Yu. A. Bezhuk, O. Martovlos (Hodovana)","doi":"10.31718/2077-1096.24.1.78","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.78","url":null,"abstract":"The study of pharmacotherapeutic (immunomodulating) action in conditions of in vitro cell cultures is currently considered appropriate and justified for determining the action of drugs at the preclinical level. It is also important to address the pathogenetic nature in using such agents, especially fro local application. This study investigated the efficacy of a multicomponent gel containing decamethoxine and hyaluronic acid in treating chronic catarrhal gingivitis among patients with chronic tonsillitis. The purpose of the work is to assess the efficacy of a gel containing decamethoxine and hyaluronic acid on the tissue of the palatine tonsils in the therapy of chronic catarrhal gingivitis in patients with chronic tonsillitis. \u0000Materials and methods. To investigate the effects of the main active components in the gel, we followed the recommendations of I.P. Kaidashev et al. for testing pharmacological preparations in in vitro cultures. Tissue samples from the palatine tonsils were obtained from 20 patients with chronic tonsillitis and chronic catarrhal gingivitis undergoing tonsillectomy. All procedures adhered to the guidelines set by the Laboratory of Pathophysiology and Immunology at Prof. O.S. Kolomiichenko Institute of Otolaryngology, National Academy of Sciences of Ukraine. Palatine tonsil tissue was incubated in 199 medium (Serva, Germany) containing gentamicin sulfate (Darnytsa, Ukraine) at a concentration of 120 μg/ml for 20 minutes at 4-8°C. After that, the hemorrhagic parts were removed from the whole tonsil and placed into Eagle's medium (Sigma, USA) and rinsed three to four times. Subsequently, the prepared tissue was placed in sterile vials containing enriched Eagle's medium supplemented with L-glutamine, sodium bicarbonate, 100x vitamin concentrate, 5% fetal calf serum, and 60 μg/mL gentamicin. Tonsil tissue was dissected using scissors and then washed repeatedly (5-7 times) with fresh medium to remove loosely attached cells, then, the resulting cell suspension was filtered. All procedures were conducted within a sterile laminar flow cabinet. Cell viability was assessed using light microscopy (Olympus-23, Japan) and a hemocytometer. A final cell suspension containing 2.5 million lymphocytes per milliliter of medium was prepared. Suspensions with a viability of less than 90% (blue, \"dead\" cells) were excluded from further experiments. \u0000Results. Treatment of in vitro palatine tonsil cells from patients with chronic catarrhal gingivitis and recurrent tonsillitis with the main components of the developed gel (decamethoxine and hyaluronic acid) did not induce significant changes in the concentration of α and γ-interferons. Our findings suggest that the gel composition reduces the levels of pro-inflammatory factors: interleukin-1β and immune complexes. Additionally, it appears to stimulate the production of the antimicrobial factor antistreptolysin-O by tonsil cells, potentially leading to increased antibody production against hemolytic","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.168
O. Akimov, A.V. Mishchenko, N. Solovyova, S.M. Nazarenko, O. E. Zakolodna, V.O. Kostenko
Among the tasks of the "Concept of Sustainable Development", it is worth highlighting tasks 3 and 4: "Good health and well-being" and "Quality education". In this way, the training of students under the educational and professional program "Medicine" at the Poltava State Medical University meets two tasks from the "Concept of Sustainable Development". Modern specialists of the medical profile are in the conditions of the need to use a scientific approach and elements of critical thinking in their professional activities. At this stage, the educational and professional program "Medicine", which provides for the training of students at the Poltava State Medical University, does not include educational components that provide students with competencies related to scientific activity (scientific writing, critical analysis of literary sources, methods of scientific research). The purpose of this work is to justify the feasibility of including the mandatory component "Scientific training" developed on the basis of the mandatory component "Pathophysiology" in the educational and professional program "Medicine" at the Poltava State Medical University. The article uses general scientific theoretical research methods such as: analysis, synthesis, comparison of concepts, abstraction and generalization. We offer the following structure of the compulsory component "Scientific training", which consists of the following modules: Module 1 "Modeling of typical pathological processes in various organs and systems", Module 2 "Methods for the study of pathological changes in organs and systems", Module 3 "Principles of pathogenetic correction of typical pathological processes" and Module 4 "Methodical approach to the analysis of obtained experimental results". The total number of credits provided for studying the compulsory component "Scientific training" is 16 credits in accordance with the European credit transfer system. Approximately 2/3 of the hours provided for the study of the mandatory component "Scientific training" are planned to be used for independent work by students of higher education. Such a number of hours for independent work is argued by the need to write an individual research paper, which is an analogue of a master's thesis in other specialties. Modernization of the educational and professional program "Medicine" by including the mandatory component "Scientific training" is a promising way of improving the quality of education for students of the II (master's) level studying in the specialty 222 "Medicine".
{"title":"THE EXPEDIENCY OF INCLUDING AN INDIVIDUAL SCIENTIFIC WORK AS A MANDATORY COMPONENT IN THE EDUCATIONAL AND PROFESSIONAL PROGRAM OF MEDICINE","authors":"O. Akimov, A.V. Mishchenko, N. Solovyova, S.M. Nazarenko, O. E. Zakolodna, V.O. Kostenko","doi":"10.31718/2077-1096.24.1.168","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.168","url":null,"abstract":"Among the tasks of the \"Concept of Sustainable Development\", it is worth highlighting tasks 3 and 4: \"Good health and well-being\" and \"Quality education\". In this way, the training of students under the educational and professional program \"Medicine\" at the Poltava State Medical University meets two tasks from the \"Concept of Sustainable Development\". \u0000Modern specialists of the medical profile are in the conditions of the need to use a scientific approach and elements of critical thinking in their professional activities. At this stage, the educational and professional program \"Medicine\", which provides for the training of students at the Poltava State Medical University, does not include educational components that provide students with competencies related to scientific activity (scientific writing, critical analysis of literary sources, methods of scientific research). \u0000The purpose of this work is to justify the feasibility of including the mandatory component \"Scientific training\" developed on the basis of the mandatory component \"Pathophysiology\" in the educational and professional program \"Medicine\" at the Poltava State Medical University. \u0000The article uses general scientific theoretical research methods such as: analysis, synthesis, comparison of concepts, abstraction and generalization. \u0000We offer the following structure of the compulsory component \"Scientific training\", which consists of the following modules: Module 1 \"Modeling of typical pathological processes in various organs and systems\", Module 2 \"Methods for the study of pathological changes in organs and systems\", Module 3 \"Principles of pathogenetic correction of typical pathological processes\" and Module 4 \"Methodical approach to the analysis of obtained experimental results\". The total number of credits provided for studying the compulsory component \"Scientific training\" is 16 credits in accordance with the European credit transfer system. Approximately 2/3 of the hours provided for the study of the mandatory component \"Scientific training\" are planned to be used for independent work by students of higher education. Such a number of hours for independent work is argued by the need to write an individual research paper, which is an analogue of a master's thesis in other specialties. \u0000Modernization of the educational and professional program \"Medicine\" by including the mandatory component \"Scientific training\" is a promising way of improving the quality of education for students of the II (master's) level studying in the specialty 222 \"Medicine\".","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.13
S. O. Guriev, P. V. Tanasienko, E. O. Skobenko
Introduction: The immune system swiftly responds to the onslaught of trauma and the infectious agents it triggers. However, the mechanisms of action of the COVID-19 virus remain unidentified to date. Distinctive alterations that occur in the immune system of trauma victims with COVID-19, setting them apart from changes observed in other diseases. This underscores the specificity of traumatic disease within this patient with COVID-19. The study aims to assess the response of humoral immunity markers in patients with fractures of long bones and COVID-19 and to explore their role in early diagnosing infectious complications in this particular group of patients. Materials and methods: To accomplish the study objectives, we assembled a retrospective dataset comprising 289 cases of skeletal bone fractures treated at the Kyiv City Clinical Hospital of Emergency Medical Care from March, 2020 to February, 2021, meeting the inclusion criteria for the study. The entire dataset consisted of 289 cases of skeletal bone fractures, categorized into two groups: the main group and the control group. Results: On the first day of treatment, an increase in some pro-inflammatory cytokines (IL-6, IL-1β and IL-4) with a normal level of TNF-α, normal values of IFN-γ, IFN-α and a sharp decrease in the anti-inflammatory cytokine IL was observed among the patients of the main group -10. On the third day of the treatment, there was a significant increase in all pro-inflammatory cytokines (IL-6, IL-1β, IL-4 and TNF-α), both types of interferons, and an even sharper decrease in the anti-inflammatory cytokine IL-10. On the tenth day, the growth in the level of pro-inflammatory cytokines was noted, among which the level of TNF-α was the leader, a subnormal level of interferons and anti-inflammatory interleukin 10 was observed. Conclusions: The dynamics of pro-inflammatory cytokines in patients with long bone fractures against the background of COVID-19 tended to increase and had a maximum level on the third day of treatment. Anti-inflammatory cytokines demonstrate a tendency to depression and reache the reference value only on the 10th day of the study.
{"title":"CYTOKINE PROFILE RESPONSE IN PATIENTS WITH FRACTURES OF LONG BONES DURING COVID-19","authors":"S. O. Guriev, P. V. Tanasienko, E. O. Skobenko","doi":"10.31718/2077-1096.24.1.13","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.13","url":null,"abstract":"Introduction: The immune system swiftly responds to the onslaught of trauma and the infectious agents it triggers. However, the mechanisms of action of the COVID-19 virus remain unidentified to date. Distinctive alterations that occur in the immune system of trauma victims with COVID-19, setting them apart from changes observed in other diseases. This underscores the specificity of traumatic disease within this patient with COVID-19. \u0000The study aims to assess the response of humoral immunity markers in patients with fractures of long bones and COVID-19 and to explore their role in early diagnosing infectious complications in this particular group of patients. \u0000Materials and methods: To accomplish the study objectives, we assembled a retrospective dataset comprising 289 cases of skeletal bone fractures treated at the Kyiv City Clinical Hospital of Emergency Medical Care from March, 2020 to February, 2021, meeting the inclusion criteria for the study. The entire dataset consisted of 289 cases of skeletal bone fractures, categorized into two groups: the main group and the control group. \u0000 Results: On the first day of treatment, an increase in some pro-inflammatory cytokines (IL-6, IL-1β and IL-4) with a normal level of TNF-α, normal values of IFN-γ, IFN-α and a sharp decrease in the anti-inflammatory cytokine IL was observed among the patients of the main group -10. On the third day of the treatment, there was a significant increase in all pro-inflammatory cytokines (IL-6, IL-1β, IL-4 and TNF-α), both types of interferons, and an even sharper decrease in the anti-inflammatory cytokine IL-10. On the tenth day, the growth in the level of pro-inflammatory cytokines was noted, among which the level of TNF-α was the leader, a subnormal level of interferons and anti-inflammatory interleukin 10 was observed. Conclusions: The dynamics of pro-inflammatory cytokines in patients with long bone fractures against the background of COVID-19 tended to increase and had a maximum level on the third day of treatment. Anti-inflammatory cytokines demonstrate a tendency to depression and reache the reference value only on the 10th day of the study.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.99
A.V. Kudriavtsev, S. I. Savosko, V.P. Kryshen, N.M. Nor
Introduction. The study of tissue reactions to the placement of polymeric materials (polypropylene mesh), used for the treatment of hernias, remains relevant. The paper examines the hypothesis regarding the existence of certain differences in tissue reactions to polypropylene implants without and with treatment of the latter with an antimicrobial agent. Objective of this study is to investigate the reaction of the tissues of the peritoneum and the muscle-aponeurotic layer of the abdominal wall to a polypropylene implant treated with thyrothricin, used for the treatment of complicated variants of inguinal hernias. Materials and methods. Experimental studies were conducted on laboratory sexually mature male Wistar rats. Experimental animals made up 4 groups of 5 animals each. The 1st group included control animals (intact). In the rats of the 2nd group, a defect of the abdominal wall of the hypogastric region was surgically modeled. In the animals of the 3rd experimental group, after modeling the defect of the abdominal wall, a polypropylene mesh implant was placed between the peritoneum and the inner leaf of the aponeurosis of the rectus abdominis muscles. The 4th experimental group consisted of animals in which the polypropylene implant was additionally treated with a thyrothricin solution. Results. During the experimental study, the integration of tissue elements of the peritoneal walls and the muscle-aponeurotic layer of the abdominal wall with the material of polypropylene meshes was revealed. Active processes of collagenogenesis were observed in the boundary zones and the area of integration with the implant, as well as pronounced manifestations of vascularization of the newly formed connective tissue. The morphological features of the connective tissue formed in the area and around intact implants and meshes treated with thyrothricin did not significantly differ from each other, but significantly prevailed over the condition of the tissues in intact animals. No particular difference between the above-mentioned changes in the tissues of animals of the 3rd and 4th groups was found. Conclusion. The obtained results indicate positive biocompatibility of body tissues and polypropylene implants. There is no negative effect of polypropylene nets treated with thyrothricin on body tissues and their regenerative potential.
{"title":"THE EFFECT OF A POLYPROPYLENE IMPLANT TREATED WITH THYROTHRICIN ON THE HYPOGASTRIC TISSUES OF THE ABDOMINAL WALL IN RATS","authors":"A.V. Kudriavtsev, S. I. Savosko, V.P. Kryshen, N.M. Nor","doi":"10.31718/2077-1096.24.1.99","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.99","url":null,"abstract":"Introduction. The study of tissue reactions to the placement of polymeric materials (polypropylene mesh), used for the treatment of hernias, remains relevant. The paper examines the hypothesis regarding the existence of certain differences in tissue reactions to polypropylene implants without and with treatment of the latter with an antimicrobial agent. Objective of this study is to investigate the reaction of the tissues of the peritoneum and the muscle-aponeurotic layer of the abdominal wall to a polypropylene implant treated with thyrothricin, used for the treatment of complicated variants of inguinal hernias. \u0000Materials and methods. Experimental studies were conducted on laboratory sexually mature male Wistar rats. Experimental animals made up 4 groups of 5 animals each. The 1st group included control animals (intact). In the rats of the 2nd group, a defect of the abdominal wall of the hypogastric region was surgically modeled. In the animals of the 3rd experimental group, after modeling the defect of the abdominal wall, a polypropylene mesh implant was placed between the peritoneum and the inner leaf of the aponeurosis of the rectus abdominis muscles. The 4th experimental group consisted of animals in which the polypropylene implant was additionally treated with a thyrothricin solution. \u0000Results. During the experimental study, the integration of tissue elements of the peritoneal walls and the muscle-aponeurotic layer of the abdominal wall with the material of polypropylene meshes was revealed. Active processes of collagenogenesis were observed in the boundary zones and the area of integration with the implant, as well as pronounced manifestations of vascularization of the newly formed connective tissue. The morphological features of the connective tissue formed in the area and around intact implants and meshes treated with thyrothricin did not significantly differ from each other, but significantly prevailed over the condition of the tissues in intact animals. No particular difference between the above-mentioned changes in the tissues of animals of the 3rd and 4th groups was found. \u0000Conclusion. The obtained results indicate positive biocompatibility of body tissues and polypropylene implants. There is no negative effect of polypropylene nets treated with thyrothricin on body tissues and their regenerative potential.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.185
G. Loban', M. Faustova, Y. Chumak
In Ukraine, student involvement in scientific research primarily occurs through participation in student scientific groups or societies. However, many teachers face challenges when supervising student research projects. This study aims at identifying challenges in supervising student scientific research in higher education, drawing on experiences of both foreign and domestic university faculties. Literature from PubMed and Google Scholar databases was reviewed, focusing on articles related to the topic. Researchers suggest early engagement of students in scientific research within laboratories and participation in inquiry-based programs such as "discovery-based," "project-based," and "inquiry-based," mirroring real-world scientific practices. These approaches offer valuable insights into science, providing structured support and laboratory experience for students. However, challenges such as material and technical limitations and teachers' lack of motivation to dedicate sufficient time to students hinder the widespread implementation of research programs in universities. To foster successful student scientific research, students must be motivated to take ownership of their work, and department laboratories require adequate material and technical support to facilitate student research groups. Additionally, scientific mentors should receive adequate pedagogical training to effectively guide research groups. Mentor efforts should focus on encouraging student participation in research activities by enhancing their awareness and creating opportunities for engagement.
在乌克兰，学生主要通过参加学生科学小组或社团来参与科学研究。然而，许多教师在指导学生科研项目时面临挑战。本研究旨在借鉴国外和国内大学院系的经验，确定在高等教育中指导学生科学研究所面临的挑战。研究人员查阅了 PubMed 和 Google Scholar 数据库中的文献，重点关注与该主题相关的文章。研究人员建议尽早让学生参与实验室内的科学研究，并参与 "基于发现"、"基于项目 "和 "基于探究 "等探究式项目，以反映真实世界的科学实践。这些方法为科学提供了宝贵的见解，为学生提供了结构化的支持和实验室经验。然而，材料和技术方面的限制以及教师缺乏为学生投入足够时间的动力等挑战，阻碍了研究计划在大学中的广泛实施。要培养学生成功地开展科学研究，就必须激励学生主动承担自己的工作，而系实验室则需要足够的物质和技术支持，以促进学生研究小组的发展。此外，科学导师应接受充分的教学培训，以有效指导研究小组。导师的工作重点应是通过提高学生的认识和创造参与机会，鼓励他们参与研究活动。
{"title":"ADDRESSING CHALLENGES IN SUPERVISING STUDENT RESEARCH","authors":"G. Loban', M. Faustova, Y. Chumak","doi":"10.31718/2077-1096.24.1.185","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.185","url":null,"abstract":"In Ukraine, student involvement in scientific research primarily occurs through participation in student scientific groups or societies. However, many teachers face challenges when supervising student research projects. This study aims at identifying challenges in supervising student scientific research in higher education, drawing on experiences of both foreign and domestic university faculties. Literature from PubMed and Google Scholar databases was reviewed, focusing on articles related to the topic. Researchers suggest early engagement of students in scientific research within laboratories and participation in inquiry-based programs such as \"discovery-based,\" \"project-based,\" and \"inquiry-based,\" mirroring real-world scientific practices. These approaches offer valuable insights into science, providing structured support and laboratory experience for students. However, challenges such as material and technical limitations and teachers' lack of motivation to dedicate sufficient time to students hinder the widespread implementation of research programs in universities. To foster successful student scientific research, students must be motivated to take ownership of their work, and department laboratories require adequate material and technical support to facilitate student research groups. Additionally, scientific mentors should receive adequate pedagogical training to effectively guide research groups. Mentor efforts should focus on encouraging student participation in research activities by enhancing their awareness and creating opportunities for engagement.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.163
I. V. Yanishen, O.V. Sidorova, R.V. Kuznetsov, N. Krychka, I. Diudina
The purpose of this study was to determine the biochemical parameters of blood of laboratory animals in prolonged contact with the experimental material Materials and methods. An experimental study was conducted in the laboratories and vivarium of the State Institution "Institute of Spine and Joint Pathology named after Prof. M.I. Sitenko" on 28 white laboratory rats aged 6 months with a body weight of 200 to 250 grams. The animals were randomly divided into two groups: a control group (14 rats) and an experimental group (14 rats), which were exposed to dental glass ionomer cement at a dose of 1.0 mg/kg. Toxic effects were evaluated for 1 month. The blood sampling procedure included tail vein dilation, disinfection, tail fixation, and blood collection. The study was conducted in special conditions with full feeding. Results. The study found no significant negative effects of prolonged use of dental glass ionomer cement (GIC) on kidney function. Analysis of diuresis, urea and creatinine levels in urine and blood serum showed no statistically significant differences between males and females. No sugar, ketones, or protein were detected in the animals' urine. Serum creatinine levels were (65.47±4.6) μmol/l in males and (63.38±7.1) μmol/l in females, while serum urea levels were (4.84±0.47) μmol/l in males and (4.67±0.42) μmol/l in females. Urinary urea levels were (374.35±20.7) mmol/l in males and (371.15±22.3) mmol/l in females. Conclusions. The obtained results of the study indicate statistically significant deviations in the studied indicators of the functional state of the kidneys both in males and females after prolonged use of dental glass-inomer cement based on polyacrylate carboxylate. The presence of sugar, ketones and protein was not detected in the urine of the animals. The analysis of serum creatinine levels showed no statistically significant differences between the conditions, and serum urea levels did not differ between them either. Thus, it can be concluded that the use of glass-inomer cement has no negative effect on the functional state of the kidneys in the studied animals.
{"title":"BIOCHEMICAL PARAMETERS OF BLOOD OF LABORATORY ANIMALS IN CASE OF PROLONGED CONTACT WITH THE RESEARCH MATERIAL","authors":"I. V. Yanishen, O.V. Sidorova, R.V. Kuznetsov, N. Krychka, I. Diudina","doi":"10.31718/2077-1096.24.1.163","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.163","url":null,"abstract":"The purpose of this study was to determine the biochemical parameters of blood of laboratory animals in prolonged contact with the experimental material \u0000Materials and methods. An experimental study was conducted in the laboratories and vivarium of the State Institution \"Institute of Spine and Joint Pathology named after Prof. M.I. Sitenko\" on 28 white laboratory rats aged 6 months with a body weight of 200 to 250 grams. The animals were randomly divided into two groups: a control group (14 rats) and an experimental group (14 rats), which were exposed to dental glass ionomer cement at a dose of 1.0 mg/kg. Toxic effects were evaluated for 1 month. The blood sampling procedure included tail vein dilation, disinfection, tail fixation, and blood collection. The study was conducted in special conditions with full feeding. \u0000Results. The study found no significant negative effects of prolonged use of dental glass ionomer cement (GIC) on kidney function. Analysis of diuresis, urea and creatinine levels in urine and blood serum showed no statistically significant differences between males and females. No sugar, ketones, or protein were detected in the animals' urine. Serum creatinine levels were (65.47±4.6) μmol/l in males and (63.38±7.1) μmol/l in females, while serum urea levels were (4.84±0.47) μmol/l in males and (4.67±0.42) μmol/l in females. Urinary urea levels were (374.35±20.7) mmol/l in males and (371.15±22.3) mmol/l in females. \u0000Conclusions. The obtained results of the study indicate statistically significant deviations in the studied indicators of the functional state of the kidneys both in males and females after prolonged use of dental glass-inomer cement based on polyacrylate carboxylate. The presence of sugar, ketones and protein was not detected in the urine of the animals. The analysis of serum creatinine levels showed no statistically significant differences between the conditions, and serum urea levels did not differ between them either. Thus, it can be concluded that the use of glass-inomer cement has no negative effect on the functional state of the kidneys in the studied animals.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140228088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.94
О.Y. Kordiyak, K.A. Moroz, Z. Honta, O. Nemesh, I. Shylivskyi
Destructive changes in the mandibular cancellous bone tissue determine the severity of periodontal diseases and affect their treatment outcomes. The imbalance between macro- and microelements leads to structural and functional changes in the spongy bone tissue of the lower jaw, and when being combined with the inflammatory process in the soft tissues of the periodontium leads to the tooth loss. Mineral elements deposited in the bones are included in the body buffer systems and are able to influence the metabolic processes of the macroorganism by mobilizing them into the bloodstream. The aim of the study is to carry out a comparative analysis of mineral element concentrations in the bone tissue of the alveolar process of the lower jaw in rats with experimentally induced periodontitis under conditions of simulated metabolic disorders and following pharmacotherapeutic correction. Materials and methods. The reseach was conducted on 80 white outbred sexually mature male rats aged 2-4 months and weighing 120-200 g. The animals were divided into 5 groups (16 in each): two control groups representing NC (negative control) and PC (conditionally positive control) and three experimental groups: I Group, II Group, III Group. The NC group consisted of animals kept on a standard vivarium diet throughout the experiment. The animals of PC, I – III Groups were exposed to peridontitis simulation: the rats received 0.04% solution of ammonium chloride (NH4Cl) per os within 30 days. Animals in group III (experimental periodontitis) received intramuscular injections of 5% meldonium dihydrate solution in a dose of 0.2 mg/kg of body weight. The rats in group IV (periodontitis treatment) received "Calcium glycerophosphate" (a first-generation calcium supplement) in a dose of 133 mg/kg. Group V (combination treatment) received both the meldonium dihydrate solution and calcium glycerophosphate in the same respective doses. Tissue levels of zinc, magnesium, strontium, calcium, sodium, potassium, phosphorus, and iron were measured using atomic absorption (zinc, magnesium), atomic emission (strontium, calcium, sodium, potassium), and photometric (phosphorus, iron) methods. Results. The change in the amount of elements in the mandibular cancellous bone tissue reveals irregularity and different mechanisms over the course of the mineralization process, depending on the chosen means of correction. The findings obtained suggest that the corrective treatments (meldonium dihydrate, calcium glycerophosphate, or their combination) promoted gradual bone density improvement through the accumulation of studied elements in the rat mandible. This indicates potential reversibility of pathological changes at this experimental stage. Conclusions. The cancellous part of the mandible in rats appears to be a dynamic system, responding actively to both detrimental factors and corrective interventions by altering the content and proportions of macro- and microelements.
{"title":"MINERAL COMPOSITION OF MANDIBULAR BONE TISSUE IN SIMULATED PERIODONTITIS DURING METABOLIC ACIDOSIS","authors":"О.Y. Kordiyak, K.A. Moroz, Z. Honta, O. Nemesh, I. Shylivskyi","doi":"10.31718/2077-1096.24.1.94","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.94","url":null,"abstract":"Destructive changes in the mandibular cancellous bone tissue determine the severity of periodontal diseases and affect their treatment outcomes. The imbalance between macro- and microelements leads to structural and functional changes in the spongy bone tissue of the lower jaw, and when being combined with the inflammatory process in the soft tissues of the periodontium leads to the tooth loss. Mineral elements deposited in the bones are included in the body buffer systems and are able to influence the metabolic processes of the macroorganism by mobilizing them into the bloodstream. \u0000The aim of the study is to carry out a comparative analysis of mineral element concentrations in the bone tissue of the alveolar process of the lower jaw in rats with experimentally induced periodontitis under conditions of simulated metabolic disorders and following pharmacotherapeutic correction. \u0000Materials and methods. The reseach was conducted on 80 white outbred sexually mature male rats aged 2-4 months and weighing 120-200 g. The animals were divided into 5 groups (16 in each): two control groups representing NC (negative control) and PC (conditionally positive control) and three experimental groups: I Group, II Group, III Group. The NC group consisted of animals kept on a standard vivarium diet throughout the experiment. The animals of PC, I – III Groups were exposed to peridontitis simulation: the rats received 0.04% solution of ammonium chloride (NH4Cl) per os within 30 days. Animals in group III (experimental periodontitis) received intramuscular injections of 5% meldonium dihydrate solution in a dose of 0.2 mg/kg of body weight. The rats in group IV (periodontitis treatment) received \"Calcium glycerophosphate\" (a first-generation calcium supplement) in a dose of 133 mg/kg. Group V (combination treatment) received both the meldonium dihydrate solution and calcium glycerophosphate in the same respective doses. Tissue levels of zinc, magnesium, strontium, calcium, sodium, potassium, phosphorus, and iron were measured using atomic absorption (zinc, magnesium), atomic emission (strontium, calcium, sodium, potassium), and photometric (phosphorus, iron) methods. \u0000Results. The change in the amount of elements in the mandibular cancellous bone tissue reveals irregularity and different mechanisms over the course of the mineralization process, depending on the chosen means of correction. The findings obtained suggest that the corrective treatments (meldonium dihydrate, calcium glycerophosphate, or their combination) promoted gradual bone density improvement through the accumulation of studied elements in the rat mandible. This indicates potential reversibility of pathological changes at this experimental stage. \u0000Conclusions. The cancellous part of the mandible in rats appears to be a dynamic system, responding actively to both detrimental factors and corrective interventions by altering the content and proportions of macro- and microelements.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.200
Полтавський державний медичний університет, Полтава, Україна, Сумський державний університет, Україна Суми
The aim of this study is to analyze the significance of such competence as "emotional intelligence" in training medical students at higher (master) medical education level, particularly thought the delievery certain disciplines. Emotional intelligence refers to the ability to recognize and manage one's own and others' emotions. Analytical studies have shown that emotional intelligence ranks as the third most important personality trait, following intelligence and conscientiousness, in determining human activity. Acquiring modern knowledge about emotional intelligence is crucial for individuals engaged in activities involving interpersonal interaction, especially for professions where individuals influence others, such as teachers-students behavior in higher education settings. The influence of a teacher on the emotional well-being of students is paramount. Communicating in the medical profession is essential, and guiding students' emotions positively is vital for enhancing their motivation to learn. Positive emotions conveyed through facial expressions, body language, and tone of voice can steer the educational process toward constructive outcomes. It is well-known that a good doctor possesses the ability to make patients feel better simply through conversation. These exceptional doctors often possess or consciously develop emotional intelligence as a character trait. Educational efforts aimed at fostering and developing emotional intelligence in future specialists are therefore crucial. Thus, modern higher education teachers must comprehend and deeply grasp the concept of emotional intelligence, being prepared to engage with students on an emotional level. Conclusion. Societal awareness of the current state of scientific understanding regarding emotional intelligence can significantly impact various aspects of society, from individual collectives to interstate relations. Faculty across disciplines should acquire knowledge about emotional intelligence to effectively carry out their teaching responsibilities. Medical students should acquire knowledge, skills, and abilities related to emotional intelligence to fulfill their professional duties successfully in the future.
{"title":"EMOTIONAL INTELLIGENCE IN THE PRACTICE OF UNIVERSITY INSTRUCTORS, MEDICAL STUDENTS, AND MEDICAL DOCTORS","authors":"Полтавський державний медичний університет, Полтава, Україна, Сумський державний університет, Україна Суми","doi":"10.31718/2077-1096.24.1.200","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.200","url":null,"abstract":"The aim of this study is to analyze the significance of such competence as \"emotional intelligence\" in training medical students at higher (master) medical education level, particularly thought the delievery certain disciplines. Emotional intelligence refers to the ability to recognize and manage one's own and others' emotions. Analytical studies have shown that emotional intelligence ranks as the third most important personality trait, following intelligence and conscientiousness, in determining human activity. Acquiring modern knowledge about emotional intelligence is crucial for individuals engaged in activities involving interpersonal interaction, especially for professions where individuals influence others, such as teachers-students behavior in higher education settings. The influence of a teacher on the emotional well-being of students is paramount. Communicating in the medical profession is essential, and guiding students' emotions positively is vital for enhancing their motivation to learn. Positive emotions conveyed through facial expressions, body language, and tone of voice can steer the educational process toward constructive outcomes. It is well-known that a good doctor possesses the ability to make patients feel better simply through conversation. These exceptional doctors often possess or consciously develop emotional intelligence as a character trait. Educational efforts aimed at fostering and developing emotional intelligence in future specialists are therefore crucial. Thus, modern higher education teachers must comprehend and deeply grasp the concept of emotional intelligence, being prepared to engage with students on an emotional level. Conclusion. Societal awareness of the current state of scientific understanding regarding emotional intelligence can significantly impact various aspects of society, from individual collectives to interstate relations. Faculty across disciplines should acquire knowledge about emotional intelligence to effectively carry out their teaching responsibilities. Medical students should acquire knowledge, skills, and abilities related to emotional intelligence to fulfill their professional duties successfully in the future.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.31718/2077-1096.24.1.234
S. Latoguz, M. Kovalev
The goal is to develop and substantiate a physical therapy program for correcting flat feet in young athletes of various sports specializations. Material and methods. The research was carried out at the City Specialized Children and Youth Sports School, Olympic Reserve, Kharkiv, focusing on the Figure Skating Department. A total of 10 participants were involved in the study. A hypothesis was formulated and subsequently validated regarding the adverse effects of specific loads in figure skating on athletes' feet. Following the acquisition of results, an affirming experiment was undertaken, involving young athletes from diverse specializations. Results. Engaging in sports carries inherent risks of diverse injuries. The prevalence of flat feet among athletes is extensively discussed in the literature, with statistics indicating that 50 to 92% of athletes across various specializations exhibit alterations in their foot arches. Addressing this issue becomes imperative, specifically through the development of an optimal rehabilitation program for children-athletes with flat feet in different specializations. An effective rehabilitation program for flat feet among young athletes of various specializations was formulated and experimentally evaluated. All athletes included in the study exhibited flat feet of the 1st or 2nd degree in their medical history. In a majority of cases, this condition was coupled with a valgus deformity. Notably, the degree of foot deformity varied between the right and left lower limbs in some instances. The rehabilitation program was seamlessly integrated into the warm-up phase of the training routine and implemented three times a week over a period of six weeks. Conclusions. The study findings conclusively highlight the efficacy of the program, as evidenced by the parameters derived from the experiment. There was a notable increase in the height of both the longitudinal and transverse arches, a reduction in the abduction angle of the 1st toe, and enhanced strength in the foot muscles. Rigorous statistical analysis of the collected data further substantiated their reliability, firmly establishing the effectiveness of the proposed rehabilitation program for athletes with flat feet. Additionally, it is noteworthy that this program can serve as a preventive measure against the development of flat feet.
{"title":"FEATURES OF PHYSICAL THERAPY FOR FLAT FEET IN YOUNG ATHLETES TREATING FLAT FEET IN YOUNG ATHLETES: A PHYSICAL THERAPY APPROACH","authors":"S. Latoguz, M. Kovalev","doi":"10.31718/2077-1096.24.1.234","DOIUrl":"https://doi.org/10.31718/2077-1096.24.1.234","url":null,"abstract":"The goal is to develop and substantiate a physical therapy program for correcting flat feet in young athletes of various sports specializations. \u0000Material and methods. The research was carried out at the City Specialized Children and Youth Sports School, Olympic Reserve, Kharkiv, focusing on the Figure Skating Department. A total of 10 participants were involved in the study. \u0000A hypothesis was formulated and subsequently validated regarding the adverse effects of specific loads in figure skating on athletes' feet. Following the acquisition of results, an affirming experiment was undertaken, involving young athletes from diverse specializations. \u0000Results. Engaging in sports carries inherent risks of diverse injuries. The prevalence of flat feet among athletes is extensively discussed in the literature, with statistics indicating that 50 to 92% of athletes across various specializations exhibit alterations in their foot arches. Addressing this issue becomes imperative, specifically through the development of an optimal rehabilitation program for children-athletes with flat feet in different specializations. An effective rehabilitation program for flat feet among young athletes of various specializations was formulated and experimentally evaluated. All athletes included in the study exhibited flat feet of the 1st or 2nd degree in their medical history. In a majority of cases, this condition was coupled with a valgus deformity. Notably, the degree of foot deformity varied between the right and left lower limbs in some instances. The rehabilitation program was seamlessly integrated into the warm-up phase of the training routine and implemented three times a week over a period of six weeks. \u0000Conclusions. The study findings conclusively highlight the efficacy of the program, as evidenced by the parameters derived from the experiment. There was a notable increase in the height of both the longitudinal and transverse arches, a reduction in the abduction angle of the 1st toe, and enhanced strength in the foot muscles. Rigorous statistical analysis of the collected data further substantiated their reliability, firmly establishing the effectiveness of the proposed rehabilitation program for athletes with flat feet. Additionally, it is noteworthy that this program can serve as a preventive measure against the development of flat feet.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140225574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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