Pub Date : 2024-09-02DOI: 10.1016/j.arabjc.2024.105984
The pervasive presence of mercury in water and cosmetics poses significant health risks, necessitating the development of a method for the in-situ monitoring and extraction of mercury ions. This study introduces a novel approach utilizing Mesoporous Silica Nanotubes (MSNTs) with a unique worm-like structure, providing an expansive surface area ideal for the adsorption of a Hg2+ ion chromophore, N,N,N,N′-Tetramethyl-4,4′-diaminobenzophenone. This configuration enables rapid and visible detection of toxic mercury, with a color transition from yellow to green that is easily discernible by the naked eye. The sensitivity of the Mercury nano-sensor (MNS) is remarkably high, with a detection limit of 1.9 × 10-8 M as determined by digital image analysis, and 4.9 × 10-8 M via spectrophotometric methods—both well below the WHO guidelines for drinking water. The MNS’s low detection threshold, coupled with its reusability after simple regeneration, positions it as an effective tool for preliminary water testing. The findings suggest that the MNS, requiring only 10 mg for measurements, offers a promising solution for the real-time visualization of mercury ions, enhancing safety measures in water and cosmetic products.
{"title":"Smartphone-enabled mesoporous silica nanotube chemosensors for quick and selective mercury detection in water and cosmetics","authors":"","doi":"10.1016/j.arabjc.2024.105984","DOIUrl":"10.1016/j.arabjc.2024.105984","url":null,"abstract":"<div><p>The pervasive presence of mercury in water and cosmetics poses significant health risks, necessitating the development of a method for the in-situ monitoring and extraction of mercury ions. This study introduces a novel approach utilizing Mesoporous Silica Nanotubes (MSNTs) with a unique worm-like structure, providing an expansive surface area ideal for the adsorption of a Hg<sup>2+</sup> ion chromophore, N,N,N,N′-Tetramethyl-4,4′-diaminobenzophenone. This configuration enables rapid and visible detection of toxic mercury, with a color transition from yellow to green that is easily discernible by the naked eye. The sensitivity of the Mercury nano-sensor (MNS) is remarkably high, with a detection limit of 1.9 × 10<sup>-8</sup> M as determined by digital image analysis, and 4.9 × 10<sup>-8</sup> M via spectrophotometric methods—both well below the WHO guidelines for drinking water. The MNS’s low detection threshold, coupled with its reusability after simple regeneration, positions it as an effective tool for preliminary water testing. The findings suggest that the MNS, requiring only 10 mg for measurements, offers a promising solution for the real-time visualization of mercury ions, enhancing safety measures in water and cosmetic products.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003861/pdfft?md5=1e88a3faefb0fde669c554a7ef41b0f6&pid=1-s2.0-S1878535224003861-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-30DOI: 10.1016/j.arabjc.2024.105977
To prevent and control the methane/coal dust compound explosion disaster, the APP-diatomite composite powder inhibition of methane/coal dust compound explosion experiments were carried out in the self-constructed pipe network. The composite powder was characterized by scanning electron microscopy and X-ray photoelectron spectroscopy. The change rules of methane/coal dust composite explosion pressure and flame propagation velocity were analyzed using different compounding ratios of powders in several monitoring points. The results show that the composite powder exhibited irregular morphology and the APP powder is uniformly distributed on the diatomite porous mesh structure. When the APP loading on the surface of diatomite is 40 wt%, composite powder has the best effect on explosion suppression, with the peak maximum explosion overpressure and the peak maximum flame propagation velocity reduced by 71.5 % and 92.2 %, respectively. The explosion suppression mechanism is revealed through pyrolysis properties, explosion products, and chain reaction.
为预防和控制甲烷/煤尘复合爆炸灾害,在自建管网中进行了APP-硅藻土复合粉末抑制甲烷/煤尘复合爆炸实验。通过扫描电镜和 X 射线光电子能谱对复合粉体进行了表征。在多个监测点采用不同的粉末复合比例分析了甲烷/煤尘复合爆炸压力和火焰传播速度的变化规律。结果表明,复合粉末呈现不规则形貌,APP粉末均匀分布在硅藻土多孔网状结构上。当硅藻土表面的APP负载量为40 wt%时,复合粉末的抑爆效果最好,最大爆炸超压峰值和最大火焰传播速度峰值分别降低了71.5%和92.2%。通过热解特性、爆炸产物和连锁反应揭示了抑爆机理。
{"title":"Experimental study on inhibiting methane-coal dust explosion by APP-diatomite composite explosion suppressant in the pipe network","authors":"","doi":"10.1016/j.arabjc.2024.105977","DOIUrl":"10.1016/j.arabjc.2024.105977","url":null,"abstract":"<div><p>To prevent and control the methane/coal dust compound explosion disaster, the APP-diatomite composite powder inhibition of methane/coal dust compound explosion experiments were carried out in the self-constructed pipe network. The composite powder was characterized by scanning electron microscopy and X-ray photoelectron spectroscopy. The change rules of methane/coal dust composite explosion pressure and flame propagation velocity were analyzed using different compounding ratios of powders in several monitoring points. The results show that the composite powder exhibited irregular morphology and the APP powder is uniformly distributed on the diatomite porous mesh structure. When the APP loading on the surface of diatomite is 40 wt%, composite powder has the best effect on explosion suppression, with the peak maximum explosion overpressure and the peak maximum flame propagation velocity reduced by 71.5 % and 92.2 %, respectively. The explosion suppression mechanism is revealed through pyrolysis properties, explosion products, and chain reaction.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003794/pdfft?md5=9870437fdb741f8f2351b09745852722&pid=1-s2.0-S1878535224003794-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-29DOI: 10.1016/j.arabjc.2024.105978
This study evaluates the application of supercritical carbon dioxide chelation extraction technology for treating heavy metal ions (Zn2+ and Cr3+) in drilling fluid waste. Through a combination of experimental and molecular dynamics simulation methods, the influence of extraction parameters (temperature, pressure, duration, and chelating agents) on the extraction efficiency are investigated. Findings show that increased duration and pressure significantly improve extraction efficiency, while temperature has a complex effect, initially increasing efficiency but plateauing and slightly decreasing at higher temperatures. The optimum extraction condition with pressure of 220 bar, temperature 348.15 K and an extraction duration of 70 min using ethylene diamine tetraacetic acid (EDTA) as the chelating agent has been determined. Importantly, molecular simulation analysis revealed that citric acid outperforms EDTA in terms of Zn2+ and Cr3+ aggregation by forming larger aggregates with greater numbers of molecules while reducing overall aggregate count. Furthermore, optimization of extraction pressure in the EDTA system shows potential benefits. These results suggest that supercritical carbon dioxide chelation extraction technology has strong potential for environmentally friendly and reliable waste management in the drilling industry. This study represents a significant step forward in developing sustainable solutions for heavy metal removal from drilling fluid waste.
{"title":"Supercritical carbon dioxide chelation extraction of heavy metal ions from drilling fluid waste: Experiment and simulation","authors":"","doi":"10.1016/j.arabjc.2024.105978","DOIUrl":"10.1016/j.arabjc.2024.105978","url":null,"abstract":"<div><p>This study evaluates the application of supercritical carbon dioxide chelation extraction technology for treating heavy metal ions (Zn<sup>2+</sup> and Cr<sup>3+</sup>) in drilling fluid waste. Through a combination of experimental and molecular dynamics simulation methods, the influence of extraction parameters (temperature, pressure, duration, and chelating agents) on the extraction efficiency are investigated. Findings show that increased duration and pressure significantly improve extraction efficiency, while temperature has a complex effect, initially increasing efficiency but plateauing and slightly decreasing at higher temperatures. The optimum extraction condition with pressure of 220 bar, temperature 348.15 K and an extraction duration of 70 min using ethylene diamine tetraacetic acid (EDTA) as the chelating agent has been determined. Importantly, molecular simulation analysis revealed that citric acid outperforms EDTA in terms of Zn<sup>2+</sup> and Cr<sup>3+</sup> aggregation by forming larger aggregates with greater numbers of molecules while reducing overall aggregate count. Furthermore, optimization of extraction pressure in the EDTA system shows potential benefits. These results suggest that supercritical carbon dioxide chelation extraction technology has strong potential for environmentally friendly and reliable waste management in the drilling industry. This study represents a significant step forward in developing sustainable solutions for heavy metal removal from drilling fluid waste.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003800/pdfft?md5=16a0cd52fde64c0ae24d8ff239a359d2&pid=1-s2.0-S1878535224003800-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-29DOI: 10.1016/j.arabjc.2024.105982
Protein fibrillation is a crucial process in the onset of several neurodegenerative and retinal disorders due to the formation of cytotoxic species. Because of their capacity to prevent protein aggregation, small molecules have the potential to be appointed as therapeutic agents. Here, we examined the inhibitory impacts of the piperonal as a carbaldehyde-derived compound on the fibrillation process of α-synuclein and underlying cytotoxicity against neuron-like (PC12) and human retinal pigment epithelial (RPE) (ARPE-19) cells. The results showed that the values of kapp and lag time of α-synuclein were modulated with piperonal. Moreover, ANS fluorescence intensity analysis indicated that piperonal can inhibit the formation of a molten global (misfolded) state of α-synuclein, which is a necessary step in the formation of protein amyloid fibrils. Congo red absorption and circular dichroism spectroscopy also verified the inhibition of β-sheet structure formation after treatment of α-synuclein with piperonal. Furthermore, theoretical studies displayed that piperonal interacts with VAL40:HN, GLU35:O, VAL40, and LYS43 amino acid residues and forms a complex. In addition, cytotoxicity assays demonstrated that piperonal as a safe small molecule could mitigate the induced cytotoxicity by α-synuclein amyloids in PC12 and ARPE-19 cells through reduction of ROS and Bax/Bcl2 mRNA overexpression. Taken together, these outcomes showed that piperonal as a natural aldehyde compound can inhibit α-synuclein fibrillation and underlying cytotoxicity which may be developed for potential therapeutic applications in vivo.
{"title":"Piperonal protects neuron-like and retinalpigment epithelial (RPE) cells from oxidative stress and apoptosis through inhibition of α-synuclein aggregation","authors":"","doi":"10.1016/j.arabjc.2024.105982","DOIUrl":"10.1016/j.arabjc.2024.105982","url":null,"abstract":"<div><p>Protein fibrillation is a crucial process in the onset of several neurodegenerative and retinal disorders due to the formation of cytotoxic species. Because of their capacity to prevent protein aggregation, small molecules have the potential to be appointed as therapeutic agents. Here, we examined the inhibitory impacts of the piperonal as a carbaldehyde-derived compound on the fibrillation process of α-synuclein and underlying cytotoxicity against neuron-like (PC12) and human retinal pigment epithelial (RPE) (ARPE-19) cells. The results showed that the values of k<sub>app</sub> and lag time of α-synuclein were modulated with piperonal. Moreover, ANS fluorescence intensity analysis indicated that piperonal can inhibit the formation of a molten global (misfolded) state of α-synuclein, which is a necessary step in the formation of protein amyloid fibrils. Congo red absorption and circular dichroism spectroscopy also verified the inhibition of β-sheet structure formation after treatment of α-synuclein with piperonal. Furthermore, theoretical studies displayed that piperonal interacts with VAL40:HN, GLU35:O, VAL40, and LYS43 amino acid residues and forms a complex. In addition, cytotoxicity assays demonstrated that piperonal as a safe small molecule could mitigate the induced cytotoxicity by α-synuclein amyloids in PC12 and ARPE-19 cells through reduction of ROS and Bax/Bcl2 mRNA overexpression. Taken together, these outcomes showed that piperonal as a natural aldehyde compound can inhibit α-synuclein fibrillation and underlying cytotoxicity which may be developed for potential therapeutic applications <em>in vivo.</em></p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003848/pdfft?md5=dcaefb1459eb9c8a74d3b7d8d23410b0&pid=1-s2.0-S1878535224003848-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-28DOI: 10.1016/j.arabjc.2024.105976
This work presents an advanced automated monolithic C18 pipette-tip solid-phase extraction (PT-SPE) method seamlessly integrated with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for precise therapeutic drug monitoring of eleven tyrosine kinase inhibitors (TKIs) in biological samples. Commercially available MonoTip C18 columns facilitate superior extraction efficiency and selectivity from complex biological matrices owing to their large surface areas and enhanced mass transfer capabilities. The sample preparation process, conducted by aspirating and dispensing solutions using a pipettor, completes the overall extraction process within 3 min. The method validation demonstrated excellent linearity within the range of 0.2/0.5/0.8 to 200 ng/mL, with detection limits ranging from 0.049 to 0.206 ng/mL. The method exhibited outstanding accuracy and precision, with intraday relative recovery rates ranging from 96.3 % to 115.0 % and interday recovery rates ranging from 95.0 % to 115.7 %, with coefficient of variation values consistently below 13.8 %. The proposed method is distinguished by its exceptional efficiency, reduced solvent use, enhanced environmental sustainability, and streamlined automation—key advantages in the realm of clinical therapeutic drug monitoring of TKIs. Overall, the MonoTip C18 PT-SPE technique, coupled with LC-MS/MS, offers a formidable, eco-friendly, and effective strategy for the TDM of TKIs, marking a significant advancement in the field.
{"title":"MonoTip C18 pipette tip solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry enables rapid and automated therapeutic drug monitoring of tyrosine kinase inhibitors","authors":"","doi":"10.1016/j.arabjc.2024.105976","DOIUrl":"10.1016/j.arabjc.2024.105976","url":null,"abstract":"<div><p>This work presents an advanced automated monolithic C18 pipette-tip solid-phase extraction (PT-SPE) method seamlessly integrated with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for precise therapeutic drug monitoring of eleven tyrosine kinase inhibitors (TKIs) in biological samples. Commercially available MonoTip C18 columns facilitate superior extraction efficiency and selectivity from complex biological matrices owing to their large surface areas and enhanced mass transfer capabilities. The sample preparation process, conducted by aspirating and dispensing solutions using a pipettor, completes the overall extraction process within 3 min. The method validation demonstrated excellent linearity within the range of 0.2/0.5/0.8 to 200 ng/mL, with detection limits ranging from 0.049 to 0.206 ng/mL. The method exhibited outstanding accuracy and precision, with intraday relative recovery rates ranging from 96.3 % to 115.0 % and interday recovery rates ranging from 95.0 % to 115.7 %, with coefficient of variation values consistently below 13.8 %. The proposed method is distinguished by its exceptional efficiency, reduced solvent use, enhanced environmental sustainability, and streamlined automation—key advantages in the realm of clinical therapeutic drug monitoring of TKIs. Overall, the MonoTip C18 PT-SPE technique, coupled with LC-MS/MS, offers a formidable, eco-friendly, and effective strategy for the TDM of TKIs, marking a significant advancement in the field.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003782/pdfft?md5=1e26df093a1ed853b309bb55290063d9&pid=1-s2.0-S1878535224003782-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1016/j.arabjc.2024.105975
The utilization of renewable solar energy for the photocatalytic transformation of carbon dioxide (CO2) into valuable chemical substances is considered an optimal strategy to simultaneously address climate challenges and tackle energy scarcity. Herein, we prepared heterojunction photocatalysts UiO-66-NH2/ZnIn2S4, which were successfully applied in the photocatalytic reduction of CO2. The yield of the main product CO, for the optimal UiO-66-NH2/ZnIn2S4-2 sample could reach up to 57 μmol g−1h−1 when converting CO2 under the visible light irradiation, which was approximately 3.35 and 2.71 times higher than that achieved by the individual UiO-66-NH2 and ZnIn2S4 samples, respectively. The better photocatalytic performance of the UiO-66-NH2/ZnIn2S4-2 composites can be attributed to its synergistic effect resulting from tight interfacial contacts, special charge transfer pathways and excellent CO2 adsorption capacity. Furthermore, the intimate contact between UiO-66-NH2 and flower-like ZnIn2S4 accelerates electron transmission while effectively suppressing the quenching of photogenerated carriers. This research provides vital knowledge for the rational design of heterostructures aimed at enhancing the efficiency of CO2 photocatalysis for solar fuel production.
{"title":"Remarkable CO2 photocatalytic reduction enabled by UiO-66-NH2 anchored on flower-like ZnIn2S4","authors":"","doi":"10.1016/j.arabjc.2024.105975","DOIUrl":"10.1016/j.arabjc.2024.105975","url":null,"abstract":"<div><p>The utilization of renewable solar energy for the photocatalytic transformation of carbon dioxide (CO<sub>2</sub>) into valuable chemical substances is considered an optimal strategy to simultaneously address climate challenges and tackle energy scarcity. Herein, we prepared heterojunction photocatalysts UiO-66-NH<sub>2</sub>/ZnIn<sub>2</sub>S<sub>4</sub>, which were successfully applied in the photocatalytic reduction of CO<sub>2</sub>. The yield of the main product CO, for the optimal UiO-66-NH<sub>2</sub>/ZnIn<sub>2</sub>S<sub>4</sub>-2 sample could reach up to 57 μmol g<sup>−1</sup>h<sup>−1</sup> when converting CO<sub>2</sub> under the visible light irradiation, which was approximately 3.35 and 2.71 times higher than that achieved by the individual UiO-66-NH<sub>2</sub> and ZnIn<sub>2</sub>S<sub>4</sub> samples, respectively. The better photocatalytic performance of the UiO-66-NH<sub>2</sub>/ZnIn<sub>2</sub>S<sub>4</sub>-2 composites can be attributed to its synergistic effect resulting from tight interfacial contacts, special charge transfer pathways and excellent CO<sub>2</sub> adsorption capacity. Furthermore, the intimate contact between UiO-66-NH<sub>2</sub> and flower-like ZnIn<sub>2</sub>S<sub>4</sub> accelerates electron transmission while effectively suppressing the quenching of photogenerated carriers. This research provides vital knowledge for the rational design of heterostructures aimed at enhancing the efficiency of CO<sub>2</sub> photocatalysis for solar fuel production.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003770/pdfft?md5=cd92ea46c1af772da4fc09231a3a70b9&pid=1-s2.0-S1878535224003770-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-23DOI: 10.1016/j.arabjc.2024.105980
A novel bio-covalent organic framework (COF: TpPa-SO3H/Lignin) based on TpPa-SO3H and lignin from lignocellulose was synthesized for chromium (Cr(VI)) remediation in this study. Results showed that TpPa-SO3H/Lignin had a highest adsorption capacity at the range of 5 ∼ 75 mg/L Cr(VI) under 10 mg/L dosage, in which 100 % Cr(VI) could be removal within 120 min. Likewise, the introduction of lignin improved the visible light response range, charge separation and photogenerated carriers, thereby improving the photocatalytic efficiency of Cr(VI) by TpPa-SO3H/Lignin. The highest photocatalytic efficiency of TpPa-SO3H/Lignin (98.56 %) was observed at the acidic conditions. ESR result shows that e- and ·O2– are generated and played an important role during the photocatalytic reaction, while the contribution of ·OH to Cr(VI) photoreduction is negligible. This study presents a sustainable and efficient approach to mitigating Cr(VI) pollution. It opens up avenues for further exploration of lignocellulose-derived materials in environmental applications and highlights the potential of COFs in addressing heavy metal contaminants.
{"title":"Synthesis of lignin-based covalent organic frameworks bio-composites: Quantitative evaluation of adsorption-photoreduction of hexavalent chromium","authors":"","doi":"10.1016/j.arabjc.2024.105980","DOIUrl":"10.1016/j.arabjc.2024.105980","url":null,"abstract":"<div><p>A novel bio-covalent organic framework (COF: TpPa-SO<sub>3</sub>H/Lignin) based on TpPa-SO<sub>3</sub>H and lignin from lignocellulose was synthesized for chromium (Cr(VI)) remediation in this study. Results showed that TpPa-SO<sub>3</sub>H/Lignin had a highest adsorption capacity at the range of 5 ∼ 75 mg/L Cr(VI) under 10 mg/L dosage, in which 100 % Cr(VI) could be removal within 120 min. Likewise, the introduction of lignin improved the visible light response range, charge separation and photogenerated carriers, thereby improving the photocatalytic efficiency of Cr(VI) by TpPa-SO<sub>3</sub>H/Lignin. The highest photocatalytic efficiency of TpPa-SO<sub>3</sub>H/Lignin (98.56 %) was observed at the acidic conditions. ESR result shows that e- and ·O<sub>2</sub><sup>–</sup> are generated and played an important role during the photocatalytic reaction, while the contribution of ·OH to Cr(VI) photoreduction is negligible. This study presents a sustainable and efficient approach to mitigating Cr(VI) pollution. It opens up avenues for further exploration of lignocellulose-derived materials in environmental applications and highlights the potential of COFs in addressing heavy metal contaminants.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003824/pdfft?md5=573fff0294d4bf3ae05aab28e2d0e24c&pid=1-s2.0-S1878535224003824-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-23DOI: 10.1016/j.arabjc.2024.105979
Uncontrolled activation of c-Kit is closely related to the pathogenesis and progression of leukemia, gastrointestinal cancer, and other malignant diseases. Although there are several inhibitors available, due to the limitation of selectivity and the unfavorable side effects, designing and discovering highly selective inhibitors targeting c-Kit kinase, especially the gain of function mutation (for example c-Kit D816V), is still necessary. To identify novel c-Kit inhibitors, a metastable state-based virtual screening approach, which was successfully implemented in other kinase inhibitors, was employed in the current study. The results from our current study demonstrated the residues adjacent to the DFG motif within the activation loop could fold into short α-helices aside from the random coil, which was commonly found in the crystal structure. By expanding the conformation pool of the activation loop via PyRosetta-based ab initio folding protocol, we constructed a series of structural models of the c-Kit kinase intermediate between the inactive and active states. After evaluation of the thermal stability of the metastable state with molecular dynamics simulation, one structural model showed higher stability of α-helix, and the activation loop was retained. Considering the wild-type and D816V mutated KIT kinase shared similar metastable states during the kinase activation process, we developed a hypothesis that the identified intermediate might hold the potential to identify inhibitors targeting D816V mutations from the compound database. As expected, the intermediate structure showed higher selectivity to KIT D816V selective inhibitors, such as bezuclastinib, avapritinib, BLU-263, and elenestinib, than imatinib or masitinib. The virtual screening of the available KIT kinase inhibitor database further identified vorolanib, semaxanib, henatinib, and pexmetinib may possess potential inhibitory effects against wild type, as well as the mutated c-Kit kinase. The results from our current study not only proposed a novel structural model that could be used for the identification of selective c-Kit D816V inhibitors but also identified several potential inhibitors from available kinase inhibitors, which might shed new light on the design of new therapeutic approaches for c-Kit mutation-driven malignant diseases.
{"title":"Intermediate-based virtual screening of c-Kit kinase inhibitors as potential anti-tumor agents via ab inito folding, molecular dynamics simulation, and molecular docking","authors":"","doi":"10.1016/j.arabjc.2024.105979","DOIUrl":"10.1016/j.arabjc.2024.105979","url":null,"abstract":"<div><p>Uncontrolled activation of c-Kit is closely related to the pathogenesis and progression of leukemia, gastrointestinal cancer, and other malignant diseases. Although there are several inhibitors available, due to the limitation of selectivity and the unfavorable side effects, designing and discovering highly selective inhibitors targeting c-Kit kinase, especially the gain of function mutation (for example c-Kit D816V), is still necessary. To identify novel c-Kit inhibitors, a metastable state-based virtual screening approach, which was successfully implemented in other kinase inhibitors, was employed in the current study. The results from our current study demonstrated the residues adjacent to the DFG motif within the activation loop could fold into short α-helices aside from the random coil, which was commonly found in the crystal structure. By expanding the conformation pool of the activation loop via PyRosetta-based <em>ab initio</em> folding protocol, we constructed a series of structural models of the c-Kit kinase intermediate between the inactive and active states. After evaluation of the thermal stability of the metastable state with molecular dynamics simulation, one structural model showed higher stability of α-helix, and the activation loop was retained. Considering the wild-type and D816V mutated KIT kinase shared similar metastable states during the kinase activation process, we developed a hypothesis that the identified intermediate might hold the potential to identify inhibitors targeting D816V mutations from the compound database. As expected, the intermediate structure showed higher selectivity to KIT D816V selective inhibitors, such as bezuclastinib, avapritinib, BLU-263, and elenestinib, than imatinib or masitinib. The virtual screening of the available KIT kinase inhibitor database further identified vorolanib, semaxanib, henatinib, and pexmetinib may possess potential inhibitory effects against wild type, as well as the mutated c-Kit kinase. The results from our current study not only proposed a novel structural model that could be used for the identification of selective c-Kit D816V inhibitors but also identified several potential inhibitors from available kinase inhibitors, which might shed new light on the design of new therapeutic approaches for c-Kit mutation-driven malignant diseases.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003812/pdfft?md5=fe84b882ec38dcc1ddd9e4208ab18f27&pid=1-s2.0-S1878535224003812-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-21DOI: 10.1016/j.arabjc.2024.105974
Utilizing synthetic insecticides to control mosquito populations has many adverse side effects as they can cause environmental pollution and insecticide resistance. Therefore, the search for eco-friendly and effective mosquito control agents has led to the exploration of plant extracts with larvicidal efficacy. In this study, we aimed to explore the larvicidal activity of four Egyptian plant extracts: Rosmarinus officinalis, Melissa officinalis, Cichorium intybus, and Beta vulgaris var. cicla against Culex pipiens and to identify the chemical constituents present in the active extracts. The methanolic extracts of the four plants were prepared and tested against the third instar larvae of C. pipiens using a standard method. The lethal concentrations (LC50 and LC90) were calculated using probit analysis. The active extracts were subjected to ultra-performance liquid chromatography-mass spectroscopy (UPLC-MS/MS) analysis and the data were processed using the global natural products social molecular networking (GNPS) platform to generate molecular networks and identify the compounds based on spectral similarity and database matching. The methanolic extracts of R. officinalis L. and M. officinalis L. had the highest larvicidal activity, where LC50 values were 9.795 and 26.505 μg/mL, respectively. Their exposure caused a high mortality rate and disrupted the biochemical and physiological parameters (total carbohydrates, total lipids, total protein, acetylcholinesterase (AChE), and glutathione S-transferase (GST) in the body of C. pipiens when compared with Cichorium intybus (Chicory) and Beta vulgaris var. cicla (Chard). The UPLC-MS/MS analysis with the aid of the GNPS platform, revealed the presence of 23 and 41 metabolites from R. officinalis L. and M. officinalis L., respectively. The identified metabolites may act as larvicidal agents by interfering with the physiological or biochemical processes of the mosquito larvae. Overall, the findings suggest that the methanolic extracts of R. officinalis and M. officinalis are potential sources of natural larvicides for mosquito control.
使用合成杀虫剂控制蚊虫数量有许多不利的副作用,因为它们会造成环境污染和杀虫剂抗药性。因此,为了寻找环保、有效的灭蚊剂,人们开始探索具有杀幼虫剂功效的植物提取物。在这项研究中,我们旨在探索四种埃及植物提取物的杀幼虫剂活性:Rosmarinus officinalis、Melissa officinalis、Cichorium intybus 和 Beta vulgaris var. cicla 对库蚊的杀幼虫活性,并确定活性提取物中的化学成分。制备了四种植物的甲醇提取物,并采用标准方法对琵鹭的三龄幼虫进行了测试。采用 probit 分析法计算致死浓度(LC50 和 LC90)。对活性提取物进行了超高效液相色谱-质谱(UPLC-MS/MS)分析,并使用全球天然产品社会分子网络(GNPS)平台对数据进行处理,以生成分子网络,并根据光谱相似性和数据库匹配鉴定化合物。R. officinalis L.和 M. officinalis L.的甲醇提取物具有最高的杀幼虫剂活性,LC50值分别为9.795和26.505 μg/mL。与菊苣(Cichorium intybus)和甜菜(Beta vulgaris var.借助 GNPS 平台进行的 UPLC-MS/MS 分析显示,R. officinalis L. 和 M. officinalis L. 分别含有 23 和 41 种代谢物。鉴定出的代谢物可能通过干扰蚊子幼虫的生理或生化过程而起到杀幼虫剂的作用。总之,研究结果表明,R. officinalis 和 M. officinalis 的甲醇提取物是用于控制蚊虫的天然杀幼虫剂的潜在来源。
{"title":"Larvicidal potency of four Egyptian herbs on Culex pipiens larvae: Phytochemical composition and molecular networking for most potent extracts","authors":"","doi":"10.1016/j.arabjc.2024.105974","DOIUrl":"10.1016/j.arabjc.2024.105974","url":null,"abstract":"<div><p>Utilizing synthetic insecticides to control mosquito populations has many adverse side effects as they can cause environmental pollution and insecticide resistance. Therefore, the search for eco-friendly and effective mosquito control agents has led to the exploration of plant extracts with larvicidal efficacy. In this study, we aimed to explore the larvicidal activity of four Egyptian plant extracts: <em>Rosmarinus officinalis</em>, <em>Melissa officinalis</em>, <em>Cichorium intybus</em>, and <em>Beta vulgaris</em> var. <em>cicla</em> against <em>Culex pipiens</em> and to identify the chemical constituents present in the active extracts. The methanolic extracts of the four plants were prepared and tested against the third instar larvae of <em>C. pipiens</em> using a standard method. The lethal concentrations (LC<sub>50</sub> and LC<sub>90</sub>) were calculated using probit analysis. The active extracts were subjected to ultra-performance liquid chromatography-mass spectroscopy (UPLC-MS/MS) analysis and the data were processed using the global natural products social molecular networking (GNPS) platform to generate molecular networks and identify the compounds based on spectral similarity and database matching. The methanolic extracts of <em>R. officinalis</em> L. and <em>M. officinalis</em> L. had the highest larvicidal activity, where LC<sub>50</sub> values were 9.795 and 26.505 μg/mL, respectively. Their exposure caused a high mortality rate and disrupted the biochemical and physiological parameters (total carbohydrates, total lipids, total protein, acetylcholinesterase (AChE), and glutathione <em>S</em>-transferase (GST) in the body of <em>C. pipiens</em> when compared with <em>Cichorium intybus</em> (Chicory) and <em>Beta vulgaris</em> var. <em>cicla</em> (Chard). The UPLC-MS/MS analysis with the aid of the GNPS platform, revealed the presence of 23 and 41 metabolites from <em>R. officinalis</em> L. and <em>M. officinalis</em> L., respectively. The identified metabolites may act as larvicidal agents by interfering with the physiological or biochemical processes of the mosquito larvae. Overall, the findings suggest that the methanolic extracts of <em>R. officinalis</em> and <em>M. officinalis</em> are potential sources of natural larvicides for mosquito control.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003769/pdfft?md5=f1a7c0627604e6dbf2746da1738d9089&pid=1-s2.0-S1878535224003769-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-20DOI: 10.1016/j.arabjc.2024.105958
In this research work, we designed a smart biodegradable PEG-coated MnO2 nanoparticles conjugated with doxorubicin (PMnO2-Dox NPs) for dual chemo-photodynamic therapy and magnetic resonance imaging (MRI) application. This highly sensitive pH-responsive PMnO2-Dox NPs causes effective drug release under acidic pH environment. PMnO2-Dox NPs not only improves the efficacy of chemo-photodynamic therapy due to synergistic response as well as improved MRI imaging via boosting T1 MRI contrast. Manifold characterization techniques have been employed for materials investigation. Crystallography of PMnO2-Dox NPs were performed by using XRD analysis, which confirmed tetragonal crystal structure with an approximate crystallite size of 20–30 nm. Surface morphology was confirmed via SEM analysis, results indicated the spherical and asymmetric agglomerated nanocluster of PMnO2-Dox NPs. In in vitro bioassay, the anticancer activity of PMnO2-Dox NPs were tested against breast cancer (MCF-7) cell line using MTT test. Moreover, it can also inhibit the growth of primary and secondary cancers without light exposure. Results suggested that PMnO2-Dox NPs not only convenient for cancer treatment via combined chemo-photodynamic therapy but also address the way towards a comprehensive strategy for MRI application via bright contrast agent T1 after overcoming the problem of multidrug resistance (MDR) and synergistic response of therapeutic analysis.
{"title":"Synergistic response of PEG coated manganese dioxide nanoparticles conjugated with doxorubicin for breast cancer treatment and MRI application","authors":"","doi":"10.1016/j.arabjc.2024.105958","DOIUrl":"10.1016/j.arabjc.2024.105958","url":null,"abstract":"<div><p>In this research work, we designed a smart biodegradable PEG-coated MnO<sub>2</sub> nanoparticles conjugated with doxorubicin (PMnO<sub>2</sub>-Dox NPs) for dual chemo-photodynamic therapy and magnetic resonance imaging (MRI) application. This highly sensitive pH-responsive PMnO<sub>2</sub>-Dox NPs causes effective drug release under acidic pH environment. PMnO<sub>2</sub>-Dox NPs not only improves the efficacy of chemo-photodynamic therapy due to synergistic response as well as improved MRI imaging via boosting T<sub>1</sub> MRI contrast. Manifold characterization techniques have been employed for materials investigation. Crystallography of PMnO<sub>2</sub>-Dox NPs were performed by using XRD analysis, which confirmed tetragonal crystal structure with an approximate crystallite size of 20–30 nm. Surface morphology was confirmed via SEM analysis, results indicated the spherical and asymmetric agglomerated nanocluster of PMnO<sub>2</sub>-Dox NPs. In <em>in vitro</em> bioassay, the anticancer activity of PMnO<sub>2</sub>-Dox NPs were tested against breast cancer (MCF-7) cell line using MTT test. Moreover, it can also inhibit the growth of primary and secondary cancers without light exposure. Results suggested that PMnO<sub>2</sub>-Dox NPs not only convenient for cancer treatment via combined chemo-photodynamic therapy but also address the way towards a comprehensive strategy for MRI application via bright contrast agent T1 after overcoming the problem of multidrug resistance (MDR) and synergistic response of therapeutic analysis.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003605/pdfft?md5=ac8abebfac84cae6090d53e319f165f5&pid=1-s2.0-S1878535224003605-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}