首页 > 最新文献

Arabian Journal of Chemistry最新文献

英文 中文
A comprehensive review of in vitro precursor feeding strategies for the overproduction of high-value plant secondary metabolites 全面回顾用于超量生产高价值植物次生代谢物的体外前体喂养策略
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-12 DOI: 10.1016/j.arabjc.2024.106018
Muhammad Rifqi Nur Ramadani, Nurul Jadid
Plant tissue culture techniques have revolutionized various aspects of modern agriculture, horticulture, and pharmaceutical industries. This method contributes to enhancing the production of plant secondary metabolites, which have noteworthy applications in pharmaceuticals, agriculture, and industry. Presently, over 50,000 plant metabolites have been identified and categorized into three primary groups: terpenoids, flavonoids, and alkaloids. Numerous studies have elucidated the metabolic pathways involved in the biosynthesis of plant compounds to better understand the metabolic flux, with the aim of identifying and engineering the production of valuable constituents. In vitro precursor feeding is one phytochemical strategy that helps increase the accumulation of plant compounds. Therefore, this review focuses on investigating the application of in vitro precursor feedings to the overproduction of a high-value phytochemicals. Moreover, it evaluates the influence of type and concentration of precursors, plant species and culture conditions as well as the phytochemical products providing insights into optimization strategies. Additionally, the potential application of accumulated terpenoids, flavonoids, and alkaloid-derived compounds for agricultural, pharmaceutical, and industrial purposes are discussed. Finally, perspective challenges and limitations related to in vitro precursor feeding strategy are addressed, including production stability, cytotoxicity effect, and uptake efficiency. The overall data presented might serve as an up-to-date report on the application of in vitro precursor feedings for enhancing plant secondary metabolite production.
植物组织培养技术为现代农业、园艺和制药业的各个方面带来了革命性的变化。这种方法有助于提高植物次生代谢物的产量,而次生代谢物在制药、农业和工业领域都有显著的应用。目前,已鉴定出 50,000 多种植物代谢物,并将其分为三大类:萜类、黄酮类和生物碱类。大量研究已经阐明了植物化合物生物合成过程中的代谢途径,以便更好地了解代谢通量,从而识别和设计有价值成分的生产。体外喂养前体是一种植物化学策略,有助于增加植物化合物的积累。因此,本综述重点研究体外前体饲喂在高价值植物化学物质过度生产中的应用。此外,它还评估了前体的类型和浓度、植物种类和培养条件以及植物化学产品的影响,为优化策略提供了启示。此外,还讨论了积累的萜类化合物、黄酮类化合物和生物碱衍生化合物在农业、制药和工业方面的潜在应用。最后,还讨论了与体外前体喂养策略相关的挑战和限制,包括生产稳定性、细胞毒性效应和吸收效率。所提供的总体数据可作为应用体外前体喂养提高植物次生代谢物产量的最新报告。
{"title":"A comprehensive review of in vitro precursor feeding strategies for the overproduction of high-value plant secondary metabolites","authors":"Muhammad Rifqi Nur Ramadani,&nbsp;Nurul Jadid","doi":"10.1016/j.arabjc.2024.106018","DOIUrl":"10.1016/j.arabjc.2024.106018","url":null,"abstract":"<div><div>Plant tissue culture techniques have revolutionized various aspects of modern agriculture, horticulture, and pharmaceutical industries. This method contributes to enhancing the production of plant secondary metabolites, which have noteworthy applications in pharmaceuticals, agriculture, and industry. Presently, over 50,000 plant metabolites have been identified and categorized into three primary groups: terpenoids, flavonoids, and alkaloids. Numerous studies have elucidated the metabolic pathways involved in the biosynthesis of plant compounds to better understand the metabolic flux, with the aim of identifying and engineering the production of valuable constituents. <em>In vitro</em> precursor feeding is one phytochemical strategy that helps increase the accumulation of plant compounds. Therefore, this review focuses on investigating the application of <em>in vitro</em> precursor feedings to the overproduction of a high-value phytochemicals. Moreover, it evaluates the influence of type and concentration of precursors, plant species and culture conditions as well as the phytochemical products providing insights into optimization strategies. Additionally, the potential application of accumulated terpenoids, flavonoids, and alkaloid-derived compounds for agricultural, pharmaceutical, and industrial purposes are discussed. Finally, perspective challenges and limitations related to <em>in vitro</em> precursor feeding strategy are addressed, including production stability, cytotoxicity effect, and uptake efficiency. The overall data presented might serve as an up-to-date report on the application of <em>in vitro</em> precursor feedings for enhancing plant secondary metabolite production.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106018"},"PeriodicalIF":5.3,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid and non-invasive estimation of total phenol content and species identification in dried wild edible bolete using FT-NIR spectroscopy 利用傅立叶变换近红外光谱仪快速、非侵入式地估算干制野生食用牛肝菌中的总酚含量并鉴定其种类
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-11 DOI: 10.1016/j.arabjc.2024.106011
Chuanmao Zheng , Jieqing Li , Honggao Liu , Yuanzhong Wang
The market for dried wild edible mushrooms is characterized by quality discrepancies and species disorganization, which are a matter of concern. The feasibility of using fourier transform near-infrared (FT-NIR) spectroscopy with chemometrics to predict the total phenol content and identify species was investigated in dried bolete. For the determination of total phenolic content, FT-NIR spectral acquisition, and two-dimensional correlation spectroscopy (2DCOS) image acquisition, five common species of dried edible bolete (n = 144) were utilized. The results showed that partial least squares regression (PLSR) combined with Fourier transform near-infrared spectroscopy could predict the total phenol content of dried boletes, with the best prediction coefficient of determination (R2p) = 0.79. The partial least squares discriminant analysis (PLS-DA) model accurately identified Phlebopus portentosus, with Matthews correlation coefficient (MCC), Precision (PRC), Sensitivity (SEN), and Specificity (SPE) all being 1. The support vector machines (SVM) model is performed optimally to identify processing edible bolete (Lanmaoa asiatica) with an accuracy of 100 % in the test set. 2DCOS images combined with the residual convolutional neural networks (ResNet) model demonstrated the feasibility of FT-NIR full spectral bands (10,000–4,000 cm−1) and characteristic spectral bands (6,500–4,000 cm−1) for species identification of boletes. The method applies to the case of consistent or inconsistent sample sizes between groups, with an accuracy of 1.00 for both the training and test sets. The study serves as a rapid, non-invasive, and convenient method for real-time evaluation of the quality of dried edible bolete in the market.
干野生食用菌市场的特点是质量参差不齐和品种杂乱无章,这引起了人们的关注。研究人员调查了使用傅立叶变换近红外光谱(FT-NIR)和化学计量学方法预测干牛肝菌的总酚含量和识别物种的可行性。在测定总酚含量、获取傅立叶变换近红外光谱和二维相关光谱(2DCOS)图像时,利用了五种常见的干食用牛肝菌(n = 144)。结果表明,偏最小二乘回归(PLSR)结合傅立叶变换近红外光谱仪可预测牛肝菌干的总酚含量,最佳预测决定系数(R2p)= 0.79。偏最小二乘判别分析(PLS-DA)模型准确地识别出了孔雀草,马修斯相关系数(MCC)、精确度(PRC)、灵敏度(SEN)和特异度(SPE)均为1。在测试集中,支持向量机(SVM)模型在识别加工食用牛肝菌(Lanmaoa asiatica)方面表现最佳,准确率达到 100%。2DCOS 图像与残差卷积神经网络(ResNet)模型相结合,证明了傅立叶变换近红外全光谱带(10,000-4,000 cm-1)和特征光谱带(6,500-4,000 cm-1)用于牛肝菌物种鉴定的可行性。该方法适用于组间样本量一致或不一致的情况,训练集和测试集的准确度均为 1.00。这项研究是一种快速、非侵入性和方便的方法,可用于实时评估市场上食用牛肝菌干的质量。
{"title":"Rapid and non-invasive estimation of total phenol content and species identification in dried wild edible bolete using FT-NIR spectroscopy","authors":"Chuanmao Zheng ,&nbsp;Jieqing Li ,&nbsp;Honggao Liu ,&nbsp;Yuanzhong Wang","doi":"10.1016/j.arabjc.2024.106011","DOIUrl":"10.1016/j.arabjc.2024.106011","url":null,"abstract":"<div><div>The market for dried wild edible mushrooms is characterized by quality discrepancies and species disorganization, which are a matter of concern. The feasibility of using fourier transform near-infrared (FT-NIR) spectroscopy with chemometrics to predict the total phenol content and identify species was investigated in dried bolete. For the determination of total phenolic content, FT-NIR spectral acquisition, and two-dimensional correlation spectroscopy (2DCOS) image acquisition, five common species of dried edible bolete (n = 144) were utilized. The results showed that partial least squares regression (PLSR) combined with Fourier transform near-infrared spectroscopy could predict the total phenol content of dried boletes, with the best prediction coefficient of determination (R<sup>2</sup>p) = 0.79. The partial least squares discriminant analysis (PLS-DA) model accurately identified <em>Phlebopus portentosus</em>, with Matthews correlation coefficient (MCC), Precision (PRC), Sensitivity (SEN), and Specificity (SPE) all being 1. The support vector machines (SVM) model is performed optimally to identify processing edible bolete (<em>Lanmaoa asiatica</em>) with an accuracy of 100 % in the test set. 2DCOS images combined with the residual convolutional neural networks (ResNet) model demonstrated the feasibility of FT-NIR full spectral bands (10,000–4,000 cm<sup>−1</sup>) and characteristic spectral bands (6,500–4,000 cm<sup>−1</sup>) for species identification of boletes. The method applies to the case of consistent or inconsistent sample sizes between groups, with an accuracy of 1.00 for both the training and test sets. The study serves as a rapid, non-invasive, and convenient method for real-time evaluation of the quality of dried edible bolete in the market.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106011"},"PeriodicalIF":5.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of xanthoxyletin with protein, molecular docking and antitumor activity in human chronic myeloid leukemia K562 cells 黄腐素与蛋白质的相互作用、分子对接以及在人类慢性髓性白血病 K562 细胞中的抗肿瘤活性
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-10 DOI: 10.1016/j.arabjc.2024.106015
Chen Wang , Zhijie You , Yihui He , Siqi Chen , Xin Chen , Shuang Qu , Ning Zhao , Xin Chen
Xanthoxyletin (C15H14O4), a natural linear pyranocoumarin, is known to trigger anti-cancer activities, although its anticancer mechanisms are largely unknown. Human hemoglobin (HHb) as a major plasma protein could play a key role in the transportation and biodistribution of therapeutic molecules In this study, the interaction of xanthoxyletin with HHb was measured under physiological conditions using multi-spectroscopic techniques along with molecular docking simulation. Also, the interaction of xanthoxyletin with human chronic myeloid leukemia K562 cells was assessed by cellular assays. It was deduced that each xanthoxyletin molecule shows a thermodynamically favorable interaction with one molecule of HHb with a binding constant (Kb) in the orders of 103-4 M−1. These interactions did not significantly result in the loss of α-helical content of HHb. In silico studies supported the experimental findings and demonstrated that non-covalent forces including hydrogen bonds (Ala88 and Arg92), pi-pi stacking (Trp37), and hydrophobic interactions (and Pro95 and Pro36) are the main forces contributing to the xanthoxyletin-HHb complex formation. Cellular and molecular assays showed that xanthoxyletin mitigated the proliferation of K562 cells through apoptosis induction mediated by overexpression of p53, caspase-3, and PARP cleavage. This data may hold great promise for the development of anticancer compounds with potential blood protein binding stemming from xanthoxyletin derivatives/hybrids.
黄腐素(C15H14O4)是一种天然的线性吡喃香豆素,具有抗癌活性,但其抗癌机制尚不清楚。人类血红蛋白(HHb)作为一种主要的血浆蛋白,可能在治疗分子的运输和生物分布中发挥关键作用。本研究利用多光谱技术和分子对接模拟,测量了黄腐酸与HHb在生理条件下的相互作用。此外,还通过细胞试验评估了黄腐酸与人类慢性髓性白血病 K562 细胞的相互作用。结果表明,每个黄腐素分子都与一分子 HHb 发生了热力学上有利的相互作用,其结合常数(Kb)在 103-4 M-1 数量级。这些相互作用不会明显导致 HHb α-螺旋成分的损失。硅学研究支持了实验结果,并证明包括氢键(Ala88和Arg92)、π-π堆叠(Trp37)和疏水相互作用(Pro95和Pro36)在内的非共价作用力是黄独素-HHb复合物形成的主要原因。细胞和分子测定显示,黄腐素通过过表达 p53、caspase-3 和 PARP 分裂诱导细胞凋亡,从而减缓了 K562 细胞的增殖。这些数据为开发具有潜在血液蛋白结合能力的黄腐素衍生物/杂交化合物带来了巨大希望。
{"title":"Interaction of xanthoxyletin with protein, molecular docking and antitumor activity in human chronic myeloid leukemia K562 cells","authors":"Chen Wang ,&nbsp;Zhijie You ,&nbsp;Yihui He ,&nbsp;Siqi Chen ,&nbsp;Xin Chen ,&nbsp;Shuang Qu ,&nbsp;Ning Zhao ,&nbsp;Xin Chen","doi":"10.1016/j.arabjc.2024.106015","DOIUrl":"10.1016/j.arabjc.2024.106015","url":null,"abstract":"<div><div>Xanthoxyletin (C<sub>15</sub>H<sub>14</sub>O<sub>4</sub>), a natural linear pyranocoumarin, is known to trigger anti-cancer activities, although its anticancer mechanisms are largely unknown. Human hemoglobin (HHb) as a major plasma protein could play a key role in the transportation and biodistribution of therapeutic molecules In this study, the interaction of xanthoxyletin with HHb was measured under physiological conditions using multi-spectroscopic techniques along with molecular docking simulation. Also, the interaction of xanthoxyletin with human chronic myeloid leukemia K562 cells was assessed by cellular assays. It was deduced that each xanthoxyletin molecule shows a thermodynamically favorable interaction with one molecule of HHb with a binding constant (K<sub>b</sub>) in the orders of 10<sup>3-4</sup> M<sup>−1</sup>. These interactions did not significantly result in the loss of α-helical content of HHb. In silico studies supported the experimental findings and demonstrated that non-covalent forces including hydrogen bonds (Ala88 and Arg92), pi-pi stacking (Trp37), and hydrophobic interactions (and Pro95 and Pro36) are the main forces contributing to the xanthoxyletin-HHb complex formation. Cellular and molecular assays showed that xanthoxyletin mitigated the proliferation of K562 cells through apoptosis induction mediated by overexpression of p53, caspase-3, and PARP cleavage. This data may hold great promise for the development of anticancer compounds with potential blood protein binding stemming from xanthoxyletin derivatives/hybrids.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106015"},"PeriodicalIF":5.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green manure (Raphanus stativus L.) alters soil microbial structure and promotes acetochlor degradation 绿肥(Raphanus stativus L.)改变土壤微生物结构并促进乙酰氯降解
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-10 DOI: 10.1016/j.arabjc.2024.106017
Qian Liu , Wanqiu Jing , Wansheng Yang, Min Huang, Ping Lu, Deyu Hu
Microorganisms play important roles in the remediation of contaminated soil. However, the relationship between the soil microbial communities and herbicide degradation remains unclear after applying green manure. The aim of this study was to investigate the effect of green manure on soil physicochemical properties, between acetochlor degradation and microbial communities. Adoption of pot experiments, the effects and mechanism of four fertilization treatments (CK: without green manure; GMV: Vicia villosa Roth; GML: Lolium perenne L.; GMR: Raphanus stativus L.) on the degradation of acetochlor were evaluated. Appling to Raphanus stativus L., acetochlor degraded in 5.82 days, which was 74.81 % higher than that of CK. Community differences in soil microbes were analysed using high-throughput sequencing. The predominant phyla of fungi were Ascomyocta, Mortierellomycota, Basidiomycota, unclassified_k_Fungi, and Chytridiomycota, which accounted for 85.01 %–116.46 % of the fungal OTUs. The green manure treatment showed higher abundance of Mortierella (9.54 %–13.05 %), diversity of saprotrophic fungi and symbiotic fungi and faster rate of degradation of acetochlor as compared to CK. In addition, soil properties such as soil total phosphorus (TP) and pH have significant effects on microorganisms. Fungal functional analysis revealed that the microorganisms associated with acetochlor biodegradation mainly belonged to Ascomycota and Glomeromycota. This study offers new insights into the relationship between soil properties and the environmental risks associated with the presence of pesticides in soil and the related mechanisms.
微生物在污染土壤的修复中发挥着重要作用。然而,施用绿肥后,土壤微生物群落与除草剂降解之间的关系仍不清楚。本研究旨在探讨绿肥对土壤理化性质、乙草胺降解和微生物群落之间的影响。通过盆栽实验,研究了四种施肥处理(CK:无绿肥;GMV:Vicia villosa Roth;GML:GMR:Raphanus stativus L.)对乙草胺降解的影响和机理进行了评估。应用 Raphanus stativus L.,乙草胺在 5.82 天内降解,比 CK 高 74.81 %。利用高通量测序分析了土壤微生物的群落差异。主要的真菌门类为 Ascomyocta、Mortierellomycota、Basidiomycota、unclassified_k_Fungi 和 Chytridiomycota,占真菌 OTU 的 85.01 %-116.46 %。与 CK 相比,绿肥处理显示出更高的莫氏菌丰度(9.54 %-13.05 %)、嗜隙真菌和共生真菌的多样性以及更快的乙酰氯降解速度。此外,土壤全磷(TP)和 pH 值等土壤特性对微生物也有显著影响。真菌功能分析显示,与乙草胺生物降解相关的微生物主要属于子囊菌目(Ascomycota)和团伞菌目(Glomeromycota)。这项研究为了解土壤特性与土壤中农药存在的环境风险之间的关系及相关机制提供了新的视角。
{"title":"Green manure (Raphanus stativus L.) alters soil microbial structure and promotes acetochlor degradation","authors":"Qian Liu ,&nbsp;Wanqiu Jing ,&nbsp;Wansheng Yang,&nbsp;Min Huang,&nbsp;Ping Lu,&nbsp;Deyu Hu","doi":"10.1016/j.arabjc.2024.106017","DOIUrl":"10.1016/j.arabjc.2024.106017","url":null,"abstract":"<div><div>Microorganisms play important roles in the remediation of contaminated soil. However, the relationship between the soil microbial communities and herbicide degradation remains unclear after applying green manure. The aim of this study was to investigate the effect of green manure on soil physicochemical properties, between acetochlor degradation and microbial communities. Adoption of pot experiments, the effects and mechanism of four fertilization treatments (CK: without green manure; GMV: <em>Vicia villosa</em> Roth; GML: <em>Lolium perenne</em> L.; GMR: <em>Raphanus stativus</em> L.) on the degradation of acetochlor were evaluated. Appling to <em>Raphanus stativus</em> L., acetochlor degraded in 5.82 days, which was 74.81 % higher than that of CK. Community differences in soil microbes were analysed using high-throughput sequencing. The predominant phyla of fungi were <em>Ascomyocta</em>, <em>Mortierellomycota</em>, <em>Basidiomycota</em>, unclassified_k_Fungi, and <em>Chytridiomycota</em>, which accounted for 85.01 %–116.46 % of the fungal OTUs. The green manure treatment showed higher abundance of <em>Mortierella</em> (9.54 %–13.05 %), diversity of saprotrophic fungi and symbiotic fungi and faster rate of degradation of acetochlor as compared to CK. In addition, soil properties such as soil total phosphorus (TP) and pH have significant effects on microorganisms. Fungal functional analysis revealed that the microorganisms associated with acetochlor biodegradation mainly belonged to <em>Ascomycota</em> and <em>Glomeromycota</em>. This study offers new insights into the relationship between soil properties and the environmental risks associated with the presence of pesticides in soil and the related mechanisms.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106017"},"PeriodicalIF":5.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological evaluation of sophoridine by interaction with plasma transport protein and protective effects in cardiomyocytes 槐定碱与血浆转运蛋白的相互作用及对心肌细胞的保护作用的生物学评价
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-09 DOI: 10.1016/j.arabjc.2024.106014
Zheng Wu, Shujuan Cheng, Shaoping Wang, Wenzheng Li, Jinghua Liu
Numerous studies have demonstrated the protective benefits of sophoridine, a bioactive alkaloid, on cell damage. However, its primary biological properties such as interaction with plasma protein, which serves as the primary drug carrier, and its cardioprotective properties are still unknown. In the present study, we aimed to analyze the binding characteristics of sophoridine with alpha-2-macroglobulin (α2M) by spectroscopic and theoretical studies. Then, the cardioprotective effects of sophoridine on myocardial ischemia/reperfusion (MI/R) injury in vitro were investigated using H9c2 cardiomyocytes. The results reveal that one molecule of sophoridine favorably binds to one molecule of α2M dominantly through interaction with hydrophobic amino acid residues (VAL758, PHE735, PHE735, and TRP739). Also, sophoridine leads to partial changes in the structure of this carrier protein in the vicinity of TRP739 residue. Cellular assays exhibit that sophoridine recovered cell viability, membrane leakage, and apoptosis induced by MI/R injury. It was detected that sophoridine could mitigate the oxidative stress and intrinsic apoptosis pathway through regulation of Bax, Bcl-2, and caspase. ELISA analysis also exhibits that sophoridine upregulates phosphorylation of Akt and PI3K in H9c2 cells. Our findings suggest that sophoridine could show favorable plasma protein interaction and promising cardioprotection against MI/R injury mediated by the upregulation of PI3K/AKT signaling pathway.
大量研究表明,槐定碱是一种生物活性生物碱,对细胞损伤具有保护作用。然而,槐定碱的主要生物学特性,如与作为主要药物载体的血浆蛋白之间的相互作用,以及它的心脏保护特性仍然未知。在本研究中,我们旨在通过光谱和理论研究分析槐定碱与α-2-巨球蛋白(α2M)的结合特性。然后,利用 H9c2 心肌细胞研究了槐定碱对体外心肌缺血再灌注(MI/R)损伤的心脏保护作用。结果发现,一分子槐定苷主要通过与疏水氨基酸残基(VAL758、PHE735、PHE735 和 TRP739)的相互作用与一分子 α2M有利地结合。此外,槐苷还会导致 TRP739 残基附近的载体蛋白结构发生部分变化。细胞实验表明,槐定碱可恢复细胞活力、膜渗漏和 MI/R 损伤诱导的细胞凋亡。研究发现,槐定碱可通过调节 Bax、Bcl-2 和 caspase 来减轻氧化应激和细胞凋亡的内在途径。ELISA 分析还显示,槐定碱可上调 H9c2 细胞中 Akt 和 PI3K 的磷酸化。我们的研究结果表明,槐定碱可通过上调 PI3K/AKT 信号通路,与血浆蛋白发生良好的相互作用,并有望对 MI/R 损伤起到保护心脏的作用。
{"title":"Biological evaluation of sophoridine by interaction with plasma transport protein and protective effects in cardiomyocytes","authors":"Zheng Wu,&nbsp;Shujuan Cheng,&nbsp;Shaoping Wang,&nbsp;Wenzheng Li,&nbsp;Jinghua Liu","doi":"10.1016/j.arabjc.2024.106014","DOIUrl":"10.1016/j.arabjc.2024.106014","url":null,"abstract":"<div><div>Numerous studies have demonstrated the protective benefits of sophoridine, a bioactive alkaloid, on cell damage. However, its primary biological properties such as interaction with plasma protein, which serves as the primary drug carrier, and its cardioprotective properties are still unknown. In the present study, we aimed to analyze the binding characteristics of sophoridine with alpha-2-macroglobulin (α2M) by spectroscopic and theoretical studies. Then, the cardioprotective effects of sophoridine on myocardial ischemia/reperfusion (MI/R) injury <em>in vitro</em> were investigated using H9c2 cardiomyocytes. The results reveal that one molecule of sophoridine favorably binds to one molecule of α2M dominantly through interaction with hydrophobic amino acid residues (VAL758, PHE735, PHE735, and TRP739). Also, sophoridine leads to partial changes in the structure of this carrier protein in the vicinity of TRP739 residue. Cellular assays exhibit that sophoridine recovered cell viability, membrane leakage, and apoptosis induced by MI/R injury. It was detected that sophoridine could mitigate the oxidative stress and intrinsic apoptosis pathway through regulation of Bax, Bcl-2, and caspase. ELISA analysis also exhibits that sophoridine upregulates phosphorylation of Akt and PI3K in H9c2 cells. Our findings suggest that sophoridine could show favorable plasma protein interaction and promising cardioprotection against MI/R injury mediated by the upregulation of PI3K/AKT signaling pathway.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106014"},"PeriodicalIF":5.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic diterpenoids from the roots of Euphorbia jolkinii Boiss against human pancreatic cancer SW1990 cells by regulating the expressions of Bcl-2, Bax, and Caspase-3 proteins 通过调节 Bcl-2、Bax 和 Caspase-3 蛋白的表达从大戟科植物 Boiss 的根中提取的二萜类化合物对人胰腺癌 SW1990 细胞具有细胞毒性
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-06 DOI: 10.1016/j.arabjc.2024.106012
Xinglong Chen , Hongbo Zhu , Haiying Zhang , Tang Zhou , Xingxi Li , Bo Hou , Weiyan Hu , Rongping Zhang
Sixteen undescribed diterpenoids were identified from Euphorbia jolkinii Boiss, a widespread invasive plant in the grassland ecosystem of subalpine meadows in southwest China, through a combination of spectroscopic data analysis. These included two casbane diterpenoids (1 and 2), two ent-atisane diterpenoids (3 and 4), and twelve ent-isopimarane diterpenoids (516). All isolates were evaluated the cytotoxicity on pancreatic cancer SW1990 cells in which compounds 1 and 9 exhibited obvious bioactivities against the tumor cells with the IC50 values of 26.50 ± 6.36 and 21.09 ± 5.98 μM respectively. Moreover, compounds 1 and 9 were found to promote the pre-apoptosis of SW1990 cells and regulate the expressions of Bcl-2, Bax, and Caspase-3 proteins to display anti-tumor abilities. Compounds 1 and 9 were subjected to Bcl-2 protein via molecular ducking to reveal their anti-tumor mechanism further. The druggability prediction showed that they possessed good drug properties with development and utilization scenarios.
通过光谱数据分析,从中国西南地区亚高山草甸草原生态系统中广泛入侵的大戟科植物Euphorbia jolkinii Boiss中鉴定出了16种未曾描述过的二萜类化合物。这些分离物包括2种casbane二萜类化合物(1和2)、2种ent-atisane二萜类化合物(3和4)以及12种ent-isopimarane二萜类化合物(5-16)。评估了所有分离物对胰腺癌 SW1990 细胞的细胞毒性,其中化合物 1 和 9 对肿瘤细胞具有明显的生物活性,IC50 值分别为 26.50 ± 6.36 和 21.09 ± 5.98 μM。此外,化合物 1 和 9 还能促进 SW1990 细胞的凋亡前期,调节 Bcl-2、Bax 和 Caspase-3 蛋白的表达,从而显示出抗肿瘤能力。为了进一步揭示化合物 1 和 9 的抗肿瘤机理,研究人员对其进行了 Bcl-2 蛋白的分子填充。可药用性预测结果表明,这两种化合物具有良好的药物特性,可以开发利用。
{"title":"Cytotoxic diterpenoids from the roots of Euphorbia jolkinii Boiss against human pancreatic cancer SW1990 cells by regulating the expressions of Bcl-2, Bax, and Caspase-3 proteins","authors":"Xinglong Chen ,&nbsp;Hongbo Zhu ,&nbsp;Haiying Zhang ,&nbsp;Tang Zhou ,&nbsp;Xingxi Li ,&nbsp;Bo Hou ,&nbsp;Weiyan Hu ,&nbsp;Rongping Zhang","doi":"10.1016/j.arabjc.2024.106012","DOIUrl":"10.1016/j.arabjc.2024.106012","url":null,"abstract":"<div><div>Sixteen undescribed diterpenoids were identified from <em>Euphorbia jolkinii</em> Boiss, a widespread invasive plant in the grassland ecosystem of subalpine meadows in southwest China, through a combination of spectroscopic data analysis. These included two casbane diterpenoids (<strong>1</strong> and <strong>2</strong>), two <em>ent</em>-atisane diterpenoids (<strong>3</strong> and <strong>4</strong>), and twelve <em>ent</em>-isopimarane diterpenoids (<strong>5</strong>–<strong>16</strong>). All isolates were evaluated the cytotoxicity on pancreatic cancer SW1990 cells in which compounds <strong>1</strong> and <strong>9</strong> exhibited obvious bioactivities against the tumor cells with the IC<sub>50</sub> values of 26.50 ± 6.36 and 21.09 ± 5.98 μM respectively. Moreover, compounds <strong>1</strong> and <strong>9</strong> were found to promote the pre-apoptosis of SW1990 cells and regulate the expressions of Bcl-2, Bax, and Caspase-3 proteins to display anti-tumor abilities. Compounds <strong>1</strong> and <strong>9</strong> were subjected to Bcl-2 protein <em>via</em> molecular ducking to reveal their anti-tumor mechanism further. The druggability prediction showed that they possessed good drug properties with development and utilization scenarios.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106012"},"PeriodicalIF":5.3,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conessine alleviates PTZ-induced epilepsy in rat model via attenuating neuroinflammation and oxidative stress 柯奈新通过减轻神经炎症和氧化应激缓解 PTZ 诱发的大鼠癫痫模型
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-05 DOI: 10.1016/j.arabjc.2024.106009
Fang Chen, Tingting Peng, Mengjiao Gou
Epilepsy is a complex neurological disorder which affects the quality life of individual and also hinders the economic status of both the individuals and the country since it requires prolonged medications. The etiology of epilepsy is varied and the neuroinflammation has been considered to be the prime initiator and the stimulator of the disease progression. Therefore anti-inflammatory drugs are suggested to treat seizure and also to prevent epilepsy. The currently available antiepileptic drugs cause’s adverse effects which obstructs the usage of these drugs and also these drugs are not cost effective. Phytochemicals are effective alternative to these drugs and it is prescribed in the traditional medicine. Conessine, a steroidal alkaloid present in bark extracts of Holarrhena sps possess antibiotic, anti-diarrheal, antimalarial and anti-inflammatory properties. We evaluated the antiepileptic potency of conessine in PTZ challenged animal model treated with 10 and 20 mg/kg of conessine respectively. The seizure induction, severity and the behavioral changes were observed in the rats. The impact of conessine on neurochemical signaling in PTZ challenged rats were assessed via quantifying the neurotransmitter and ATPase levels in the brain tissue. Antioxidants and MDA levels were measured to evaluate the antioxidant potency of conessine in epilepsy induced rats. iNOS and nNOS which are inducers of NO during epileptic conditions were analyzed in the test rats. The stimulators and inflammatory cytokines levels were quantified in the brain to analyze the anti-neuroinflammatory efficacy of the conessine in PTZ challenged rats. AKT/mTOR prime signaling proteins in initiation and progression of epilepsy was quantified in the brain tissue of experimental animals. Neurodegeneration inducers cytochrome c, NF-κB, COX-2 and Caspase 3 were quantified to evaluate the ameliorative potency of conessine against PTZ induced neuronal damage. The neuroprotective and antiepileptic potency of conessine was confirmed with the histopathological scoring of brain tissue in PTZ challenged rats. Conessine treatment effectively inhibited the seizure induction and regulated the neurochemical signaling in epileptic induced rats. It also attenuated the neuroinflammation and oxidative stress induction induced by PTZ treatment. The prime signaling proteins nitric oxide synthatase and AKT/mTOR signaling proteins were effectively inhibited by the conessine treatment which eventually prevented the neurodegeneration inducers. Conessine treatment significantly enhanced the levels of Caspase 3. The histopathological analysis confirms the neuroprotective, anti-inflammatory and antiepileptic potency of conessine. Conessine treatment also doesn’t caused any behavioral alterations in the rats hence it is safe and potent alternative for currently available antiepileptic drugs.
癫痫是一种复杂的神经系统疾病,不仅影响个人的生活质量,而且由于需要长期服药,还阻碍了个人和国家的经济状况。癫痫的病因多种多样,神经炎症被认为是疾病进展的主要诱因和刺激因素。因此,建议使用抗炎药物来治疗癫痫发作和预防癫痫。目前可用的抗癫痫药物会产生不良反应,阻碍了这些药物的使用,而且这些药物的成本效益也不高。植物化学物质是这些药物的有效替代品,也是传统医学的处方药。科尼辛是一种甾体生物碱,存在于 Holarrhena sps 树皮提取物中,具有抗生素、止泻、抗疟和消炎特性。我们分别用 10 毫克/千克和 20 毫克/千克的海茴香碱对 PTZ 挑战动物模型进行了抗癫痫药效评估。我们观察了大鼠癫痫发作的诱导、严重程度和行为变化。通过量化脑组织中的神经递质和 ATP 酶水平,评估了鹅肌肽对 PTZ 挑战大鼠神经化学信号传导的影响。通过测量抗氧化剂和 MDA 水平,评估了鹅肌肽在癫痫诱导大鼠体内的抗氧化能力。对脑部的刺激因子和炎症细胞因子水平进行量化,以分析柯尼辛在 PTZ 挑战大鼠中的抗神经炎症功效。在实验动物的脑组织中定量检测了 AKT/mTOR 信号蛋白在癫痫发生和发展过程中的作用。对神经退行性诱导剂细胞色素 c、NF-κB、COX-2 和 Caspase 3 进行了定量分析,以评估柯尼辛对 PTZ 诱导的神经元损伤的改善作用。通过对 PTZ 挑战大鼠脑组织进行组织病理学评分,证实了科尼辛的神经保护和抗癫痫作用。科尼辛能有效抑制癫痫大鼠的癫痫发作,调节神经化学信号传导。它还能减轻 PTZ 治疗诱导的神经炎症和氧化应激。一氧化氮合酶和 AKT/mTOR 信号转导蛋白被柯尼辛有效抑制,最终防止了神经退行性变的诱导。海茴香碱能明显提高 Caspase 3 的水平。组织病理学分析证实了科尼辛的神经保护、抗炎和抗癫痫作用。科尼辛治疗也不会对大鼠造成任何行为改变,因此它是现有抗癫痫药物的安全而有效的替代品。
{"title":"Conessine alleviates PTZ-induced epilepsy in rat model via attenuating neuroinflammation and oxidative stress","authors":"Fang Chen,&nbsp;Tingting Peng,&nbsp;Mengjiao Gou","doi":"10.1016/j.arabjc.2024.106009","DOIUrl":"10.1016/j.arabjc.2024.106009","url":null,"abstract":"<div><div>Epilepsy is a complex neurological disorder which affects the quality life of individual and also hinders the economic status of both the individuals and the country since it requires prolonged medications. The etiology of epilepsy is varied and the neuroinflammation has been considered to be the prime initiator and the stimulator of the disease progression. Therefore anti-inflammatory drugs are suggested to treat seizure and also to prevent epilepsy. The currently available antiepileptic drugs cause’s adverse effects which obstructs the usage of these drugs and also these drugs are not cost effective. Phytochemicals are effective alternative to these drugs and it is prescribed in the traditional medicine. Conessine, a steroidal alkaloid present in bark extracts of Holarrhena sps possess antibiotic, anti-diarrheal, antimalarial and anti-inflammatory properties. We evaluated the antiepileptic potency of conessine in PTZ challenged animal model treated with 10 and 20 mg/kg of conessine respectively. The seizure induction, severity and the behavioral changes were observed in the rats. The impact of conessine on neurochemical signaling in PTZ challenged rats were assessed via quantifying the neurotransmitter and ATPase levels in the brain tissue. Antioxidants and MDA levels were measured to evaluate the antioxidant potency of conessine in epilepsy induced rats. iNOS and nNOS which are inducers of NO during epileptic conditions were analyzed in the test rats. The stimulators and inflammatory cytokines levels were quantified in the brain to analyze the anti-neuroinflammatory efficacy of the conessine in PTZ challenged rats. AKT/mTOR prime signaling proteins in initiation and progression of epilepsy was quantified in the brain tissue of experimental animals. Neurodegeneration inducers cytochrome <em>c</em>, NF-κB, COX-2 and Caspase 3 were quantified to evaluate the ameliorative potency of conessine against PTZ induced neuronal damage. The neuroprotective and antiepileptic potency of conessine was confirmed with the histopathological scoring of brain tissue in PTZ challenged rats. Conessine treatment effectively inhibited the seizure induction and regulated the neurochemical signaling in epileptic induced rats. It also attenuated the neuroinflammation and oxidative stress induction induced by PTZ treatment. The prime signaling proteins nitric oxide synthatase and AKT/mTOR signaling proteins were effectively inhibited by the conessine treatment which eventually prevented the neurodegeneration inducers. Conessine treatment significantly enhanced the levels of Caspase 3. The histopathological analysis confirms the neuroprotective, anti-inflammatory and antiepileptic potency of conessine. Conessine treatment also doesn’t caused any behavioral alterations in the rats hence it is safe and potent alternative for currently available antiepileptic drugs.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106009"},"PeriodicalIF":5.3,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of Viticis Fructus: botany, historical records, phytochemistry, pharmacology, toxicity, quality control, pharmacokinetics and comprehensive applications 枸橘综述:植物学、历史记录、植物化学、药理学、毒性、质量控制、药代动力学和综合应用
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-02 DOI: 10.1016/j.arabjc.2024.106008
Xue Meng , Yang Liu , Suyi Liu , Qianqian Zhang , Kunze Du , Omachi Daniel Ogaji , Lirong Wang , Xingyue Jin , Jin Li , Yanxu Chang

Background

Viticis Fructus (also known as Manjingzi) has been used in China for more than 2000 years. It is one of the most famous traditional Chinese medicines with the main effect of dispelling wind-heat. In Asian countries, it is used in the treatment of common cold with wind-heat syndrome, swollen gums, migraines, dizziness, etc.

The aim of the review

The paper emphasizes on the botany, historical records, phytochemistry, pharmacology, toxicity, quality control, pharmacokinetics and comprehensive applications of Viticis Fructus to furnish with a scientific theoretical reference for its exploration and applications.

Materials and methods

Correlative data on Viticis Fructus were obtained from PubMed, ScienceDirect, Web of science, Embase, Scopus, Google Scholar, CNKI, WeiPu, Chinese ancient books and DuXiu academic search. The data collection ended in May 2024.

Results

The results showed 324 compounds, including terpenoids, flavonoids, lignans and others, which were isolated and identified from Viticis Fructus. In addition to treating headaches and eye pain, Viticis Fructus also had anti-inflammatory, antiplatelet activation, analgesia, antitumor and antihypertensive effects. In addition, this review summarized the botany, toxicity, counterfeit identification, pharmacokinetics and patent information of Viticis Fructus in detail. The shortcomings and feasible suggestions are put forward, which provide a basis for further research and utilization of Viticis Fructus.

Conclusion

Viticis Fructus has been used to remedy common cold with wind-heat syndrome, cephalalgia, ophthalmodynia, dizziness, etc. The pharmacological activities of the main components have been clarified and backed up the traditional applications. However, the botany, processing, pharmacological mechanism, quality control and toxicological studies of Viticis Fructus need to be further improved.
背景蔓荆子在中国已有 2000 多年的历史。它是最著名的传统中药之一,主要功效是祛风热。综述目的 本文着重对蔓荆子的植物学、历史记载、植物化学、药理学、毒性、质量控制、药代动力学及综合应用进行了研究,为蔓荆子的开发和应用提供科学的理论参考。材料与方法有关蔓荆子的相关数据来自 PubMed、ScienceDirect、Web of science、Embase、Scopus、Google Scholar、CNKI、卫朴、中国古籍和独秀学术搜索。结果表明,从紫云英中分离并鉴定出 324 种化合物,包括萜类、黄酮类、木脂素等。除了治疗头痛和眼痛外,维蒂丝果实还具有抗炎、抗血小板激活、镇痛、抗肿瘤和降血压的作用。此外,本综述还详细总结了维药的植物学、毒性、假药识别、药代动力学和专利信息。结论蔓荆子用于治疗风热感冒、头痛、目赤、眩晕等症。其主要成分的药理活性已得到明确,并为传统应用提供了支持。然而,葡萄科植物的植物学、加工、药理机制、质量控制和毒理学研究还需要进一步完善。
{"title":"A review of Viticis Fructus: botany, historical records, phytochemistry, pharmacology, toxicity, quality control, pharmacokinetics and comprehensive applications","authors":"Xue Meng ,&nbsp;Yang Liu ,&nbsp;Suyi Liu ,&nbsp;Qianqian Zhang ,&nbsp;Kunze Du ,&nbsp;Omachi Daniel Ogaji ,&nbsp;Lirong Wang ,&nbsp;Xingyue Jin ,&nbsp;Jin Li ,&nbsp;Yanxu Chang","doi":"10.1016/j.arabjc.2024.106008","DOIUrl":"10.1016/j.arabjc.2024.106008","url":null,"abstract":"<div><h3>Background</h3><div>Viticis Fructus (also known as Manjingzi) has been used in China for more than 2000 years. It is one of the most famous traditional Chinese medicines with the main effect of dispelling wind-heat. In Asian countries, it is used in the treatment of common cold with wind-heat syndrome, swollen gums, migraines, dizziness, <em>etc</em>.</div></div><div><h3>The aim of the review</h3><div>The paper emphasizes on the botany, historical records, phytochemistry, pharmacology, toxicity, quality control, pharmacokinetics and comprehensive applications of Viticis Fructus to furnish with a scientific theoretical reference for its exploration and applications.</div></div><div><h3>Materials and methods</h3><div>Correlative data on Viticis Fructus were obtained from PubMed, ScienceDirect, Web of science, Embase, Scopus, Google Scholar, CNKI, WeiPu, Chinese ancient books and DuXiu academic search. The data collection ended in May 2024.</div></div><div><h3>Results</h3><div>The results showed 324 compounds, including terpenoids, flavonoids, lignans and others, which were isolated and identified from Viticis Fructus. In addition to treating headaches and eye pain, Viticis Fructus also had anti-inflammatory, antiplatelet activation, analgesia, antitumor and antihypertensive effects. In addition, this review summarized the botany, toxicity, counterfeit identification, pharmacokinetics and patent information of Viticis Fructus in detail. The shortcomings and feasible suggestions are put forward, which provide a basis for further research and utilization of Viticis Fructus.</div></div><div><h3>Conclusion</h3><div>Viticis Fructus has been used to remedy common cold with wind-heat syndrome, cephalalgia, ophthalmodynia, dizziness, <em>etc</em>. The pharmacological activities of the main components have been clarified and backed up the traditional applications. However, the botany, processing, pharmacological mechanism, quality control and toxicological studies of Viticis Fructus need to be further improved.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 12","pages":"Article 106008"},"PeriodicalIF":5.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
U(Ⅵ) sorption by porous sodium zirconium phosphate pellets from aqueous solution 多孔磷酸锆钠颗粒从水溶液中吸附铀(Ⅵ)的情况
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-10-01 DOI: 10.1016/j.arabjc.2024.106007
Cheng Wang , Bingtao Gui , Tianjie Li , Ruiyang Chang , Junxiang Shu , Xiaoqin Deng , Li Chen , Maodan Luo , Bing Jiang , Su Xu , Juan Zhai , Jun Liu , Changsong Zhao
Zirconium phosphate is the first artificially produced layered phosphate that can sorb a variety of nuclides from solutions. Sodium zirconium phosphate (NZP) was a type of α-zirconium phosphate (α-ZrP). The porous sodium zirconium phosphate pellets (p-NZP-P) with a diameter of more than ∼3 mm were prepared and used for uranium sorption. The p-NZP-P could be immersed in solutions for more than 5 days without dissolving and structurally collapsing. The sorption properties of U(Ⅵ) on p-NZP-P in solutions were investigated by both static and dynamic sorption tests. Synthetic p-NZP-P was analyzed in detail using various characterizations to investigate their character and structural changes. In the static sorption experiment, the equilibrium sorption capacity reached the 77.5 ± 1.5 mg·g−1 when the initial concentration of U(Ⅵ) was 100 mg/L, pHinitial = 4.5, T = 25 ℃. Uranium sorption increased by ∼69 % and ∼215 %, respectively, when the initial uranium concentration was increased from 100 to 300 mg·L−1 and the temperature was increased from 15 to 55 °C. Furthermore, uranium sorption increased by ∼541 % when the initial pH increased from 2.5 to 4.5, while it decreased by ∼39 % when the initial pH increased from 4.5 to 7.0. The sorption data corresponded to the pseudo-second-order kinetic model and the Langmuir isotherm model, as well as the theoretically predicted value of sorption capacity (∼199.9 mg·g−1). The results of the dynamic sorption experiment showed that decreasing the quality, increasing the flow rate and the initial U(Ⅵ) concentration would shorten the breakthrough time. The dynamic sorption data agreed well with the Thomas model. The characterization confirmed the porous properties, while the U(Ⅵ) sorption mechanisms relate to –OH coordination and ion exchange. A radioactive rare earth wastewater treatment test suggested that p-NZP-P could be the potential uranium sorbent due to its good stability and efficiency. This paper opened opportunities for the development of practical materials for treating radioactive wastewater in the application of actual scenarios.
磷酸锆是第一种人工生产的层状磷酸盐,可以从溶液中吸附各种核素。磷酸锆钠(NZP)是α-磷酸锆(α-ZrP)的一种。制备了直径大于 ∼3 mm 的多孔磷酸锆钠颗粒(p-NZP-P),并将其用于铀吸附。p-NZP-P 可在溶液中浸泡 5 天以上而不会溶解和结构坍塌。通过静态和动态吸附试验研究了溶液中 p-NZP-P 对铀(Ⅵ)的吸附特性。利用各种表征方法对合成的 p-NZP-P 进行了详细分析,以研究其特性和结构变化。在静态吸附实验中,当铀(Ⅵ)的初始浓度为 100 mg/L,pHinitial = 4.5,T = 25 ℃时,平衡吸附容量达到 77.5 ± 1.5 mg-g-1。当初始铀浓度从 100 mg-L-1 增加到 300 mg-L-1,温度从 15 ℃ 增加到 55 ℃ 时,铀吸附量分别增加了 ∼69 % 和 ∼215 %。此外,当初始 pH 值从 2.5 升至 4.5 时,铀吸附量增加了 ∼541 %,而当初始 pH 值从 4.5 升至 7.0 时,铀吸附量减少了 ∼39 %。吸附数据符合假二阶动力学模型和 Langmuir 等温线模型,也符合吸附容量的理论预测值(∼199.9 mg-g-1)。动态吸附实验结果表明,降低质量、增加流速和初始 U(Ⅵ)浓度都会缩短突破时间。动态吸附数据与托马斯模型十分吻合。表征证实了其多孔特性,而铀(Ⅵ)的吸附机理则与 -OH 配位和离子交换有关。放射性稀土废水处理试验表明,p-NZP-P 具有良好的稳定性和高效性,可能成为潜在的铀吸附剂。本文为在实际应用场景中开发处理放射性废水的实用材料提供了机会。
{"title":"U(Ⅵ) sorption by porous sodium zirconium phosphate pellets from aqueous solution","authors":"Cheng Wang ,&nbsp;Bingtao Gui ,&nbsp;Tianjie Li ,&nbsp;Ruiyang Chang ,&nbsp;Junxiang Shu ,&nbsp;Xiaoqin Deng ,&nbsp;Li Chen ,&nbsp;Maodan Luo ,&nbsp;Bing Jiang ,&nbsp;Su Xu ,&nbsp;Juan Zhai ,&nbsp;Jun Liu ,&nbsp;Changsong Zhao","doi":"10.1016/j.arabjc.2024.106007","DOIUrl":"10.1016/j.arabjc.2024.106007","url":null,"abstract":"<div><div>Zirconium phosphate is the first artificially produced layered phosphate that can sorb a variety of nuclides from solutions. Sodium zirconium phosphate (NZP) was a type of α-zirconium phosphate (α-ZrP). The porous sodium zirconium phosphate pellets (p-NZP-P) with a diameter of more than ∼3 mm were prepared and used for uranium sorption. The p-NZP-P could be immersed in solutions for more than 5 days without dissolving and structurally collapsing. The sorption properties of U(Ⅵ) on p-NZP-P in solutions were investigated by both static and dynamic sorption tests. Synthetic p-NZP-P was analyzed in detail using various characterizations to investigate their character and structural changes. In the static sorption experiment, the equilibrium sorption capacity reached the 77.5 ± 1.5 mg·g<sup>−1</sup> when the initial concentration of U(Ⅵ) was 100 mg/L, pH<sub>initial</sub> = 4.5, <em>T</em> = 25 ℃. Uranium sorption increased by ∼69 % and ∼215 %, respectively, when the initial uranium concentration was increased from 100 to 300 mg·L<sup>−1</sup> and the temperature was increased from 15 to 55 °C. Furthermore, uranium sorption increased by ∼541 % when the initial pH increased from 2.5 to 4.5, while it decreased by ∼39 % when the initial pH increased from 4.5 to 7.0. The sorption data corresponded to the pseudo-second-order kinetic model and the Langmuir isotherm model, as well as the theoretically predicted value of sorption capacity (∼199.9 mg·g<sup>−1</sup>). The results of the dynamic sorption experiment showed that decreasing the quality, increasing the flow rate and the initial U(Ⅵ) concentration would shorten the breakthrough time. The dynamic sorption data agreed well with the Thomas model. The characterization confirmed the porous properties, while the U(Ⅵ) sorption mechanisms relate to –OH coordination and ion exchange. A radioactive rare earth wastewater treatment test suggested that p-NZP-P could be the potential uranium sorbent due to its good stability and efficiency. This paper opened opportunities for the development of practical materials for treating radioactive wastewater in the application of actual scenarios.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 11","pages":"Article 106007"},"PeriodicalIF":5.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Fabrication of exchange coupled hard/soft magnetic nanocomposites: Correlation between composition, magnetic, optical and microwave properties” [Arab. J. Chem. 14(3) (2021) 102992] 对 "交换耦合硬/软磁纳米复合材料的制备:成分、磁性、光学和微波特性之间的相关性" [Arab.
IF 5.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-28 DOI: 10.1016/j.arabjc.2024.106006
Y. Slimani , N.A. Algarou , M.A. Almessiere , A. Sadaqat , M.G. Vakhitov , D.S. Klygach , D.I. Tishkevich , A.V. Trukhanov , S. Güner , A.S. Hakeem , I.A. Auwal , A. Baykal , A. Manikandan , I. Ercan
{"title":"Corrigendum to “Fabrication of exchange coupled hard/soft magnetic nanocomposites: Correlation between composition, magnetic, optical and microwave properties” [Arab. J. Chem. 14(3) (2021) 102992]","authors":"Y. Slimani ,&nbsp;N.A. Algarou ,&nbsp;M.A. Almessiere ,&nbsp;A. Sadaqat ,&nbsp;M.G. Vakhitov ,&nbsp;D.S. Klygach ,&nbsp;D.I. Tishkevich ,&nbsp;A.V. Trukhanov ,&nbsp;S. Güner ,&nbsp;A.S. Hakeem ,&nbsp;I.A. Auwal ,&nbsp;A. Baykal ,&nbsp;A. Manikandan ,&nbsp;I. Ercan","doi":"10.1016/j.arabjc.2024.106006","DOIUrl":"10.1016/j.arabjc.2024.106006","url":null,"abstract":"","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 11","pages":"Article 106006"},"PeriodicalIF":5.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142359678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Arabian Journal of Chemistry
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1