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2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)最新文献

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Circuit implementation of fluorescence lifetime measurement using direct exponential-to-linear conversion 电路实现荧光寿命测量使用直接指数到线性转换
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584734
M. Punjiya, S. Sonkusale
Measurement of fluorescent lifetime is key in many biological analyses. Recently, we proposed a new scheme for fluorescent lifetime measurement utilizing hardware level linearization of the fluorescent decay produced by an excited fluorphore. This method is less sensitive to equivalent voltage and time errors compared to commonly utilized charge modulation schemes and has no upper limit on lifetime measurement. Here we present results for a hardware level implementation of the proposed scheme for lifetime measurement. Preliminary results demonstrate extraction of lifetimes down to 5/µs.
荧光寿命的测量是许多生物分析的关键。最近,我们提出了一种新的荧光寿命测量方案,利用硬件级线性化的荧光衰减产生的激发荧光。与常用的电荷调制方法相比,该方法对等效电压和时间误差的敏感性较低,并且对寿命测量没有上限。在这里,我们给出了寿命测量方案的硬件级实现的结果。初步结果表明,提取寿命低至5/µs。
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引用次数: 0
A Nano-Filter-Integrated CMOS Image Sensor for Fluorescent Biomedical Imaging 用于荧光生物医学成像的纳米滤波器集成CMOS图像传感器
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584706
Yu Jiang, Hao Yu, Xiaojian Fu, Chathuranga Hettiarachchi, He Xu, Ye Li, T. Nguyen, Longtao Dong, Cuong Dang, Qing Zhang
This paper presents a fluorescent image sensor with the integrated plasmonic nano-filter using metal layers in CMOS. The readout circuit is fully integrated with a high-gain pixel-level capacitive trans-impedance amplifier (CTIA), column-level amplifier, and correlated double sampling (CDS). The nano-filter achieved 51-dB simulated rejection ratio for 467-nm excitation light and 820-nm emission light. Considering low photodiode quantum efficiency and interference, a 24.2-dB system rejection ratio was achieved in measurement. In addition, liquid samples with/without PbS quantum dots (QDs) can be identified with 22-dB transmittance difference.
本文提出了一种集成等离子体纳米滤波器的荧光图像传感器。读出电路完全集成了高增益像素级电容式反阻抗放大器(CTIA)、列级放大器和相关双采样(CDS)。该纳米滤波器对467 nm激发光和820 nm发射光的模拟抑制比为51 db。考虑到光电二极管量子效率低和干扰,在测量中获得了24.2 db的系统抑制比。此外,有/没有PbS量子点(QDs)的液体样品可以识别22 db的透射率差异。
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引用次数: 1
Embedded Phase-Amplitude Coupling Based Closed-loop Platform for Parkinson's Disease 基于相位振幅耦合的嵌入式帕金森病闭环平台
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584699
Molly Alexandre, Song Luan, Z. Mari, W. Anderson, Y. Salimpour, T. Constandinou, L. Grand
Deep Brain Stimulation (DBS) is a widely used clinical therapeutic modality to treat Parkinsons disease refractory symptoms and complications of levodopa therapy. Currently available DBSsystems use continuous, open-loop stimulation strategies. It might be redundant and we could extend the battery life otherwise. Recently, robust electrophysiological signatures of Parkinsons disease have been characterized in motor cortex of patients undergoing DBS surgery. Reductions in the beta-gamma Phase-Amplitude coupling (PAC) correlated with symptom improvement, and the therapeutic effects of DBS itself. We aim to develop a miniature, implantable and adaptive system, which only stimulates the neural target, when triggered by the output of the appropriate PAC algorithm. As a first step, in this paper we compare published PAC algorithms by using human data intra-operatively recorded from Parkinsonian patients. We then introduce IIR masking for later achieving fast and low-power FPGA implementation of PAC mapping for intra-operative studies. Our closed-loop application is expected to consume significantly less power than current DBS systems, therefore we can increase the battery life, without compromising clinical benefits.
脑深部电刺激(DBS)是临床上广泛应用的治疗帕金森病左旋多巴治疗的顽固性症状和并发症的治疗方式。目前可用的dbs系统采用连续开环增产策略。它可能是多余的,否则我们可以延长电池寿命。最近,在接受DBS手术的患者的运动皮层中发现了帕金森病的强大电生理特征。β - γ相幅耦合(PAC)的减少与症状改善和DBS本身的治疗效果相关。我们的目标是开发一种微型的、可植入的、自适应的系统,当适当的PAC算法输出触发时,它只刺激神经目标。作为第一步,在本文中,我们通过使用帕金森病患者术中记录的人类数据来比较已发表的PAC算法。然后,我们引入IIR掩蔽,以便稍后实现快速和低功耗的FPGA实现PAC映射,用于术中研究。我们的闭环应用预计比目前的DBS系统消耗更少的功率,因此我们可以在不影响临床效益的情况下延长电池寿命。
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引用次数: 1
Live Demonstration of Portable Systems based on Silicon Sensors for the monitoring of Physiological Parameters of Driver Drowsiness and Pulse Wave Velocity 基于硅传感器的便携式驾驶员困倦生理参数和脉搏波速度监测系统的现场演示
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584709
S. Conoci, F. Rundo, G. Fallica, Davide Lena, Irene Buraioli, D. Demarchi
In this paper we present a PHYSIO-Sensor based on STM proprietary technology able to accurately reconstruct in a portable format both the PPG (PhotoPlethysmoGraphy) signal and Pulse Wave Velocity (PWV).
在本文中,我们提出了一种基于STM专有技术的物理传感器,能够以便携式格式准确重建PPG(光电体积脉搏波)信号和脉冲波速度(PWV)。
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引用次数: 15
Lung Nodule Segmentation Using Pleural Wall Shape 利用胸膜壁形状分割肺结节
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584661
Yunfei Li, Xiang Xie, Guolin Li, Zhihua Wang
A lung nodule segmentation method is proposed to deal with juxta-pleural nodules in CT scans by smartly wrapping pleural wall shape into segmentation. The global pleural wall shape model is estimated by components analysis from adjacent CT slices to capture its invariant features of anatomical structure. In order to grasp more refined pleura features in each slice, the estimated global shape model is combined with local intensity and morphological features adaptively to produce final pleural wall segmentation through a level set based propagation algorithm. With the extracted pleural wall, the lung nodules can be segmented well by a level set method based on intensity contrast between nodule and background even when the nodules are attached to the pleural wall. The experimental results show that the proposed method can achieve DSC value of 0.70 on 175 juxta-pleural nodules from LIDC-IDRI database, outperforming the state of art method on this kind of nodules.
提出了一种肺结节分割方法,将胸膜形状巧妙地包裹到CT扫描中,以处理胸膜旁结节。通过对相邻CT切片的分量分析,估计出整体胸膜壁形状模型,以捕捉其解剖结构的不变特征。为了在每个切片中掌握更精细的胸膜特征,将估计的全局形状模型与局部强度和形态学特征自适应结合,通过基于水平集的传播算法产生最终的胸膜壁分割。利用提取的胸膜壁,即使结节附着在胸膜壁上,基于结节与背景强度对比的水平集方法也能很好地分割肺结节。实验结果表明,该方法对LIDC-IDRI数据库中175个胸膜旁结节的DSC值为0.70,优于现有方法。
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引用次数: 1
Live Demonstration: HemeChip - A Portable Microchip Electrophoresis Technology for Point-of-Care Sickle Cell Disease Screening 现场演示:HemeChip -一种便携式微芯片电泳技术,用于镰状细胞病的即时筛查
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584795
M. N. Hasan, A. Fraiwan, U. Gurkan, J. Little
HemeChip is the first miniaturized, single-use cartridge-based microchip electrophoresis system for identifying and quantifying hemoglobin (Hb) variants from a drop of blood at the point-of-care (POC). It is estimated that 7% of world's population lives with a hemoglobin variant, and one of the most common and severe one being the recessively transmitted sickle hemoglobin which results in Sickle Cell Disease (SCD). HemeChip (Fig. 1A,C) separates Hb variants on a strip of cellulose acetate (CA) paper that is housed in the HemeChip cartridge. This HemeChip cartridge is a mass-producible, single-use cartridge that maintains a controlled environment and a constant electric field (applied through the electrodes, Fig. 1B) for the Hb separation process. The cartridge also contains an in-chip blotting mechanism and an anti-fogging feature. The anti-fogging feature is essential for real-time imaging and tracking of Hb band(s) during the separation process. HemeChip is integrated with a portable reader (Fig. 1D) to detect the type(s) and fraction of hemoglobin types present in a blood sample. HemeChip technology has been designed and developed to offer a robust, user-friendly platform to detect, identify, and quantify Hb variants (responsible for SCD variants) even in a limited resource settings.
HemeChip是首个小型化、一次性使用的微晶片电泳系统,用于在护理点(POC)鉴定和定量一滴血中的血红蛋白(Hb)变异。据估计,世界上7%的人口患有一种血红蛋白变异,其中最常见和最严重的一种是隐性传播的镰状血红蛋白,可导致镰状细胞病(SCD)。HemeChip(图1A,C)在放置在HemeChip药盒中的醋酸纤维素(CA)纸条上分离Hb变体。HemeChip墨盒是一种可批量生产的一次性墨盒,可保持受控环境和恒定电场(通过电极施加,图1B),用于Hb分离过程。墨盒还包含一个芯片内印迹机制和防雾功能。在分离过程中,抗雾特性对于Hb波段的实时成像和跟踪至关重要。HemeChip集成了便携式读取器(图1D),用于检测血液样本中存在的血红蛋白类型和比例。HemeChip技术的设计和开发提供了一个强大的、用户友好的平台,即使在资源有限的情况下,也可以检测、识别和量化Hb变异(负责SCD变异)。
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引用次数: 2
Computational stereo-vision model of proto-object based saliency in three-dimensional space 三维空间中基于原目标显著性的计算立体视觉模型
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584679
Elena Mancinelli, E. Niebur, R. Etienne-Cummings
Our visual system deals with a three-dimensional space but most of the current saliency models do not include depth information. We extend a proto-object based model to show how stereoscopic depth perception changes the ability to predict saliency on natural scenes. Results show the ability to mark depth discontinuities and a promising statistical improvement.
我们的视觉系统处理三维空间,但目前大多数显著性模型不包括深度信息。我们扩展了基于原型对象的模型,以显示立体深度感知如何改变预测自然场景显著性的能力。结果表明,该方法能够标记深度不连续,并且在统计上有很大的改进。
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引用次数: 3
Multi-coil High Efficiency Wireless Charger System for Hermetically Sealed Biomedical Implants 密封生物医学植入物多线圈高效无线充电系统
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584726
Jihun Lee, A. Nurmikko
Biomedical inductively-coupled transcutaneous implants with internal batteries typically rely on a two-coil charging system which places fundamental and practical limits such as requiring short coil-to-coil distance for useful Wireless Power Transfer (WPT) efficiency. In case of hermetic metal enclosures equipped with finite size dielectric window for magnetic flux penetration, two-coil configurations can induce substantial additional loss due to eddy currents generated on e.g. Ti metal surface by fringing B-fields. Dissipative losses are unwelcome as they increase the temperature of the implant. We focus here on high-performance implants with internal electronic circuits and power source which require frequent, rapid battery recharging. The case example is a wireless broadband neural recording device capable of high data rate transmission (> 40 Mbps). We describe a compact planar four-coil configuration to achieve efficient Wireless Power Transfer (WPT) across tissue layers exceeding 1 cm. For the device geometry discussed here, our system transfers up to 73 % and 46 % of RF energy across 16 mm-separated source-to-load coil, in absence or presence of a Ti-enclosure which embeds the energy harvesting coil pair respectively. Thin sheets of ferrites are integrated to enhance local B-fields. We are able to charge a 200 mAh medical-grade battery to useful 84% of its full charge capacity (near current saturation) within 1 hour through a sapphire window integrated with the hermetic Ti- enclosure. The measured temperature increase is 2.1 °C with Ti-can immersed in still saline, slightly above FDA requirements or more recent ISO standards. From physiological models, we expect that active cooling by body tissue surrounding the implant (such as microvasculature perfusion) will provide for a safe and efficient WPT method.
带有内部电池的生物医学电感耦合经皮植入物通常依赖于双线圈充电系统,这在基础和实践上存在限制,例如需要较短的线圈到线圈距离来实现有用的无线电力传输(WPT)效率。对于配备有有限尺寸介电窗的密闭金属外壳,用于磁通穿透,双线圈配置可能会由于在钛金属表面上由边缘b场产生的涡流而导致大量额外损失。耗散损耗是不受欢迎的,因为它们会增加植入物的温度。我们专注于具有内部电子电路和电源的高性能植入物,需要频繁,快速的电池充电。本案例是一种具有高数据传输速率(> 40 Mbps)的无线宽带神经记录设备。我们描述了一个紧凑的平面四线圈配置,以实现有效的无线电力传输(WPT)跨越超过1厘米的组织层。对于这里讨论的器件几何形状,我们的系统在没有或存在ti外壳(分别嵌入能量收集线圈对)的情况下,通过16 mm间隔的源-负载线圈传输高达73%和46%的射频能量。薄铁氧体片被集成以增强局部b场。我们能够在1小时内通过集成了密封钛外壳的蓝宝石窗口将200毫安时的医疗级电池充电至84%的可用电量(接近电流饱和)。测量的温度升高为2.1°C, Ti-can浸入盐水中,略高于FDA要求或最近的ISO标准。从生理模型来看,我们期望植入物周围的身体组织主动冷却(如微血管灌注)将提供一种安全有效的WPT方法。
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引用次数: 2
Automatic Artifact Reduction Based on MEMD- for Seizure Prediction 基于MEMD-的癫痫发作预测自动伪影减少
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584675
Lihan Tang, Menglian Zhao, Yizhao Zhou, Xiaobo Wu
The performance of seizure prediction is usually affected by various kinds of artifacts, especially by physiological artifacts. To improve the performance of seizure prediction, this paper proposed an automatic artifact reduction method based on multivariate empirical mode decomposition and independent component analysis (MEMD-ICA). The proposed method could identify electrooculography (EOG) and electromyographic (EMG) artifacts precisely while keeping the useful neural signals as much as possible. The performance of seizure prediction has been significantly improved with an accuracy of 90.59% and a sensitivity of 91.09% based on CHB-MIT database.
癫痫发作预测的性能通常受到各种伪影的影响,尤其是生理伪影。为了提高癫痫发作预测的性能,提出了一种基于多元经验模态分解和独立分量分析(MEMD-ICA)的伪影自动降噪方法。该方法既能准确识别眼电信号和肌电信号伪影,又能尽可能保留有用的神经信号。基于CHB-MIT数据库的癫痫发作预测准确率为90.59%,灵敏度为91.09%。
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引用次数: 2
New system for nitrites and nitrates detection from natural water sources 天然水源中亚硝酸盐和硝酸盐检测新系统
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584698
C. Moldovan, M. Ion, S. Dinulescu, M. Savin, C. Brasoveanu, B. Firtat, M. Gartner, C. Lete, S. Mihaiu, M. Gheorghe, S. Gheorghe
The research paper will present a new energy autonomous system based on micro electrochemical sensors and ultra-thin solar cells, for concentration measurement of different ionic species in natural water sources. It focuses on the following directions: a) new microsensors for detection of nitrites and nitrates in natural water sources and b) low cost autonomous energy system integration and fabrication. The microsensors for nitrates/nitrites and heavy metals will be of electrochemical type, miniaturized, fully integrated, fabricated by micro - nano technology and connected to the electronic module that is providing detection, data acquisition and interpretation and data display. The chronoamperometry and voltammetry characterisation will be presented and the results in nitrites and nitrates detection will be provided. The energy harvester is including a UTSC, a dedicated storage and a power stabilizing device. SnO2, TiO2, ZnO, Pt-Au alloy, FTO materials have been optimised for sensors and solar cells.
本研究将提出一种基于微型电化学传感器和超薄太阳能电池的新型能源自主系统,用于天然水源中不同离子种类的浓度测量。重点研究以下方向:a)用于检测天然水源中亚硝酸盐和硝酸盐的新型微传感器;b)低成本自主能源系统集成和制造。用于硝酸盐/亚硝酸盐和重金属的微传感器将是电化学型的、小型化的、完全集成的、采用微纳米技术制造的,并与提供检测、数据采集和解释以及数据显示的电子模块相连。将介绍计时安法和伏安法表征,并提供亚硝酸盐和硝酸盐检测的结果。能量采集器包括一个UTSC,一个专用存储和一个功率稳定装置。SnO2, TiO2, ZnO, Pt-Au合金,FTO材料已被优化用于传感器和太阳能电池。
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引用次数: 1
期刊
2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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