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2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)最新文献

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Two-Port Networks to Model Galvanic Coupling for Intrabody Communications and Power Transfer to Implants 双端口网络模型电耦合体内通信和电力传输到植入物
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584691
Laura Becerra-Fajardo, Marc Tudela-Pi, A. Ivorra
Galvanic coupling, or more precisely, volume conduction, can be used to communicate with and to transfer power to electronic implants. Since no bulky components for power, such as coils or batteries, are required within the implants, this strategy can yield very thin devices suitable for implantation by injection. To design the circuitry of both the implants and the external systems, it is desirable to possess a model that encompasses the behavior of these circuits and also the volume conduction phenomenon. Here we propose to model volume conduction with a two-port network so that the whole system can be studied in circuit simulators. The two-port network consists only of three impedances whose values can be obtained through simple measurements or through numerical methods. We report a validation of this modeling approach in a geometrically simple in vitro setup that allowed us to determine the impedances of the two-port network not only by performing measurements or through a finite element method study but also through an analytical solution.
电偶,或者更准确地说,体积传导,可用于与电子植入物通信并将电力传输到电子植入物。由于植入物中不需要线圈或电池等笨重的电源组件,因此该策略可以产生非常薄的设备,适合通过注射植入。为了设计植入体和外部系统的电路,需要拥有一个包含这些电路行为和体积传导现象的模型。在这里,我们建议用一个双端口网络来模拟体积传导,以便在电路模拟器中研究整个系统。双端口网络仅由三个阻抗组成,其值可以通过简单的测量或通过数值方法获得。我们报告了在几何上简单的体外设置中对这种建模方法的验证,该设置使我们不仅可以通过执行测量或通过有限元方法研究,还可以通过解析解来确定双端口网络的阻抗。
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引用次数: 7
Wireless Power and Data Link for Ensembles of Sub-mm scale Implantable Sensors near 1GHz 近1GHz亚毫米级可植入传感器集成的无线电源和数据链路
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584725
Jihun Lee, F. Laiwalla, J. Jeong, Chester Kilfoyle, L. Larson, A. Nurmikko, Siwei Li, Siyuan Yu, V. Leung
We describe a custom wireless power and data transmission (WPDT) link and analyze its performance in a prototype implantable sensor system of ensembles of CMOS sensor ASICs (“Neurograins”) embedding 0.5 mm × 0.5 mm planar microcoil antennas. We use near-field RF at ~1 GHz for wireless powering in a resonant 3-coil architecture including an implanted relay coil in a quadrant layout architecture to maximize coverage area and RF transfer efficiency. We demonstrate successful WPDT across antenna cross-section in benchtop proxy physiological tests. Demodulation and analysis of backscattered signals validate the data link fidelity. Our results suggest that this electromagnetic coupling scheme can robustly support a chip density of 250/ cm2(up to 1024 individual Neurograins in a 2 cm × 2 cm area) and parallel transmitters can be combined to multiply the channel capacity without destructive interference.
我们描述了一种定制的无线电源和数据传输(WPDT)链路,并分析了其在嵌入0.5 mm × 0.5 mm平面微线圈天线的CMOS传感器asic(“神经颗粒”)集成的原型植入式传感器系统中的性能。我们使用~1 GHz的近场RF在谐振3线圈架构中进行无线供电,包括在象限布局架构中植入中继线圈,以最大化覆盖面积和RF传输效率。我们在台式代理生理测试中成功地展示了跨天线截面的WPDT。对后向散射信号的解调和分析验证了数据链路的保真度。我们的研究结果表明,这种电磁耦合方案可以稳定地支持250/ cm2的芯片密度(在2cm × 2cm区域内多达1024个单独的神经粒),并且可以组合并行发射器以增加信道容量而不会产生破坏性干扰。
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引用次数: 25
Capacitive Wireless Power and Data Transfer for Implantable Medical Devices 植入式医疗设备的电容式无线电源和数据传输
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584824
Asish Koruprolu, S. Nag, R. Erfani, P. Mohseni
Reliable data transmission and sustainable wireless powering are key for a majority of implantable medical devices for performing a multitude of operations. This paper proposes and demonstrates an experimental working bench-top model for the first time of a wireless powering scheme for bio-medical implants through a 2-contact resonant capacitive link where data has been transmitted simultaneously in a hybrid amplitude-frequency shift keying (ASK-FSK) technique over the same channel. This technique is well suited for a high-density micro-stimulation implants and the data telemetry rate is independent of the power carrier frequency. A proof-of-concept table-top setup using 20 mm × 20 mm flexible and conformable capacitive patches with a beef slice of 3 mm thickness demonstrates this idea and helps us carry out preliminary experiments. Experimental results show that for an air-kapton gap between the capacitive patches, the power delivered to the load (PDL) is up to 90 mW with data transfer rate of 170 kbps and power transfer efficiency (PTE) of 70%, whereas for a 3 mm thick beef tissue sample separation with the same setup, the observed PDL was 12 mW with a PTE of 36%.
可靠的数据传输和可持续的无线供电是大多数植入式医疗设备执行多种操作的关键。本文首次提出并演示了一种生物医学植入物无线供电方案的实验工作台模型,该方案通过双触点谐振电容链路,在同一信道上以混合幅频移键控(ASK-FSK)技术同时传输数据。该技术非常适合于高密度微刺激植入物,且数据遥测速率与功率载波频率无关。一个概念验证桌面装置使用20mm × 20mm柔性和一致性电容贴片和3 mm厚度的牛肉片证明了这一想法,并帮助我们进行初步实验。实验结果表明,当电容贴片之间存在空气-卡普顿间隙时,传递给负载的功率(PDL)高达90 mW,数据传输速率为170 kbps,功率传输效率(PTE)为70%,而在相同设置下,对于3 mm厚的牛肉组织样品分离,所观察到的PDL为12 mW, PTE为36%。
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引用次数: 14
A Clockless Method of Flicker Noise Suppression in Continuous-Time Acquisition of Biosignals 生物信号连续时间采集中闪烁噪声抑制的无时钟方法
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584788
M. Maslik, T. Lande, T. Constandinou
This paper presents a novel chopping method allowing suppression of 1/f flicker noise in continuous-time acquisition systems without the need for a fixed-frequency clock, stochastically deriving the chopping signal from the input and hence achieving completely signal-dependent power consumption. The method is analysed, its basis of operation explained and a proof-of-concept implementation presented alongside simulated results demonstrating an increase in achieved SNR of more than 8 dB during acquisition of ECG, EAP and EEG signals.
本文提出了一种新的斩波方法,该方法可以在不需要固定频率时钟的情况下抑制连续时间采集系统中的1/f闪烁噪声,从输入随机地导出斩波信号,从而实现完全依赖于信号的功耗。分析了该方法,解释了其操作基础,并给出了概念验证实现,同时模拟结果表明,在采集ECG, EAP和EEG信号时,实现的信噪比增加超过8 dB。
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引用次数: 4
Extracting the Cole-Cole Model Parameters of Tissue-mimicking Materials 组织模拟材料的Cole-Cole模型参数提取
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584724
M. Fouda, Ahmed E. Khorshid, Ibrahim N. Alquaydheb, A. Eltawil, F. Kurdahi
Tissue mimicking materials are used as a safe alternative testing platform during the development of medical applications such as wearables devices and body area networks. Identifying the accurate electrical properties of the materials in use is important to guarantee accuracy and reproducibility of results. In this paper, we propose a novel extraction technique for the Cole-Cole model of tissue-mimicking materials. The proposed method is based on optimizing the relative error for both real and imaginary parts of the complex permittivity of the fabricated materials. Extracting the model is helpful to study the effect of changing materials percentages to fit the real human body tissues. The proposed technique, when applied to in-house developed tissue-mimicking materials, showed a good match with relative error less than 5% in both permittivity parts.
在可穿戴设备和身体区域网络等医疗应用的开发过程中,组织模拟材料被用作安全的替代测试平台。确定所用材料的准确电性能对于保证结果的准确性和可重复性非常重要。本文提出了一种新的模拟组织材料Cole-Cole模型提取技术。该方法是基于优化复合介电常数实部和虚部的相对误差。该模型的提取有助于研究改变材料百分比对拟合真实人体组织的影响。将该技术应用于自主开发的组织模拟材料中,结果表明,两者介电常数部分的相对误差均小于5%。
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引用次数: 3
Smart Prosthesis System: Continuous Automatic Prosthesis Fitting Adjustment and Real-time Stress Visualization 智能假体系统:连续自动假体装配调整和实时应力可视化
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584784
Y. Cai, Jia Chen, Diliang Chen, Guanzhou Qu, Hong-Ke Zhao, Rahila Ansari, Ming-chun Huang
Prosthetic devices have significantly improved mobility and quality of life for amputees. Significant engineering advancements have been made in artificial limb biomechanics, joint control systems, and light-weight materials. Amputees report that the primary problem they face with their artificial limbs is a poor fitting socket. In this paper, we propose a smart prosthesis system, in which we measure the real-time force distributions within a prothetic socket and dynamically visualize the results in a mobile application. A major part of the overall proposed system, a wireless pressure sensing system and a force visualization method, are evaluated at current stage. Finally, corresponding works for fully completing this smart prosthesis system are discussed as well.
假肢装置显著改善了截肢者的活动能力和生活质量。在假肢生物力学、关节控制系统和轻质材料方面取得了重大的工程进展。截肢者报告说,他们的假肢面临的主要问题是一个不合适的插座。在本文中,我们提出了一种智能假体系统,在该系统中,我们测量假体插槽内的实时力分布,并在移动应用程序中动态可视化结果。目前,对整个系统的主要部分无线压力传感系统和力可视化方法进行了评估。最后,对完整完成该智能假肢系统所需要做的工作进行了讨论。
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引用次数: 2
A Compact and Accelerated Spike-based Neuromorphic VLSI Chip for Pattern Recognition 一种用于模式识别的紧凑型加速尖峰神经形态VLSI芯片
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584765
Cheng Li, Y. Wang, Jin Zhang, Xiaoxin Cui, Ru Huang
In this paper, we present a compact and accelerated spike-based neuromorphic chip that support on-line pattern recognition. The chip integrates 100 input layer neurons and 7000 synaptic plasticity circuits to handle the pattern classification problem of a 10×10 input pixel array. With the mechanism of spike-timing dependent plasticity (STDP) circuits and teacher signals, the chip can support both supervised learning and unsupervised learning. Fabricated in a 55nm technology, the core circuits occupies the area of 623×540 μm2The simulation results show that the chip can handle the pattern recognition task such as MNIST data set classification, and the power consumption is about 5.5mW.
在本文中,我们提出了一个紧凑和加速的神经形态芯片,支持在线模式识别。该芯片集成了100个输入层神经元和7000个突触可塑性电路,用于处理10×10输入像素阵列的模式分类问题。该芯片利用脉冲时序依赖的可塑性(STDP)电路和教师信号的机制,同时支持监督学习和无监督学习。仿真结果表明,该芯片能够处理MNIST数据集分类等模式识别任务,功耗约为5.5mW。
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引用次数: 3
A Charge Balanced Neural Stimulator with 3.3 V to 49 V Supply Compliance and Arbitrary Programmable Current Pulse Shapes 3.3 V至49 V电源兼容和任意可编程电流脉冲形状的电荷平衡神经刺激器
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584755
Armin Taschwer, Natalie Butz, Manuel Kohler, D. Rossbach, Y. Manoli
A power-efficient six channel prototype of a neural stimulator, with arbitrary programmable current pulse shapes, and a high voltage compliance of up to 49 V is presented. Rectangular, sinusoidal and exponential shapes are possible, supporting e.g. selective stimulation via anodal and HF block. It features high flexibility in current amplitudes from 2 µA to 10 mA with 9-bit resolution per biphasic current DAC, current settling time constant of 0.8 µs, and low voltage headroom. Each channel is equipped with passive charge balancing by a high voltage switch with adequate on-resistance of 2 kΩ. Two channels are additionally equipped with active charge balancing by a PI-controlled offset compensation. The smallest achievable overall static power consumption is 20.8 µW per channel and 41 µW if active charge balancing (CB) is enabled.
提出了一种低功耗的六通道神经刺激器原型,具有任意可编程电流脉冲形状,并具有高达49 V的高电压顺应性。矩形,正弦和指数形状是可能的,例如通过阳极和高频块支持选择性刺激。它具有高灵活性,电流幅度从2µA到10 mA,每个双相电流DAC具有9位分辨率,电流稳定时间常数为0.8µs,电压余量低。每个通道都配备了一个高压开关,具有足够的导通电阻2 kΩ的被动电荷平衡。两个通道额外配备了一个pi控制的偏移补偿有源电荷平衡。最小可实现的整体静态功耗为20.8µW /通道,如果启用有源电荷平衡(CB)则为41µW。
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引用次数: 11
Trapped charge cancellation for CMOS ISFET sensors via Direct Tunnelling CMOS ISFET传感器的直接隧穿阱电荷抵消
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584686
Yuanqi Hu, P. Georgiou
In this paper Direct Tunnelling current has been used as a mechanism to cancel the Trapped Charge commonly found in unmodified CMOS ISFETs. Our analysis has shown that PMOS devices could be used, having minimum leakage current in normal operation whilst providing considerable large tunnelling current for compensation with gate biasing. We integrate a flip-flop into each sensing pixel to allow self-locking of the gate bias during the charge cancellation process. Our analysis shows that we can use the proposed approach to cancel the trapped charge within 10 minutes, introducing only lu V /s of drift at the output. We demonstrate this mechanism with a 4×4 sensor array operating with a 3-step cancellation process and include simulation results showing the charge cancellation mechanism.
在本文中,直接隧穿电流被用来作为一种机制来消除在未修改的CMOS isfet中常见的捕获电荷。我们的分析表明,PMOS器件可以在正常工作时具有最小的泄漏电流,同时提供相当大的隧穿电流来补偿栅极偏置。我们将一个触发器集成到每个传感像素中,以便在电荷消除过程中自锁定门偏置。我们的分析表明,我们可以使用所提出的方法在10分钟内取消捕获电荷,在输出端只引入6 V /s的漂移。我们通过4×4传感器阵列演示了这种机制,该传感器阵列具有3步取消过程,并包括显示电荷取消机制的仿真结果。
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引用次数: 3
Objective Human Gustatory Sensitivity Assessment Through a Portable Electronic Device 目的利用便携式电子仪器评价人体味觉敏感性
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584809
E. Sulas, Alice E. Martis, P. Cosseddu, A. Achilli, G. Sollai, I. Barbarossa, L. Raffo, A. Bonfiglio, D. Pani
Objective assessment of taste perception is a challenging problem. In general, psychophysical tests based on the administration of a prototypical bitter compound, 6-n-propyltiouracil (PROP), and on a subjective scoring, are exploited. Since the PROP tasting ability is correlated to food preference and also to several clinical and health-related conditions, the development of low-cost hardware/software tools for accurate testing (e.g., in pharmacies) is an important goal. Previous works revealed the possibility to perform an electrophysiological measurement on the tongue able to provide objectiveness and repeatability in this kind of study. The technique, called Electrotastegram (ETG), relies on a custom thin-film electrode and an off-the-shelf electrophysiological recording system. In this work, we present a prototypical low-cost pocket-sized wireless device for ETG, comparing the signal quality against a top-class electrophysiological recording system already used for the same measurements. A custom Matlab interface was developed to collect and process the signal. By acquiring the signals at the same time with both devices, it was possible to compare the quality in terms of noise, amplitude and waveform. The results reveal a substantial equivalence between the two devices, thus opening to the possibility of using the proposed system in real scenarios, possibly substituting the Matlab interface with a stand-alone software.
味觉的客观评价是一个具有挑战性的问题。在一般情况下,心理物理测试基于一个原型苦化合物,6-n-丙基尿嘧啶(PROP)的管理,并在主观评分,被利用。由于PROP的品尝能力与食物偏好有关,也与几种临床和健康相关状况有关,因此开发用于准确检测的低成本硬件/软件工具(例如,在药房)是一个重要目标。以前的工作揭示了在舌头上进行电生理测量的可能性,能够在这种研究中提供客观性和可重复性。这项技术被称为electrotastgram (ETG),它依赖于一个定制的薄膜电极和一个现成的电生理记录系统。在这项工作中,我们提出了一种用于ETG的低成本口袋大小的无线设备原型,并将信号质量与已经用于相同测量的顶级电生理记录系统进行了比较。开发了一个定制的Matlab接口来采集和处理信号。通过同时使用两种设备获取信号,可以比较噪声,幅度和波形方面的质量。结果揭示了两个设备之间的实质等同,从而打开了在实际场景中使用所提出系统的可能性,可能用独立软件取代Matlab接口。
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引用次数: 1
期刊
2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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