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The Outcome of Biofeedback Muscle Re-Education after Brachial Plexus Reconstruction: a Case Series 臂丛神经重建术后生物反馈肌肉再教育的效果:一个病例系列
Pub Date : 2020-02-28 DOI: 10.20473/SPMRJ.V2I1.2020.35-41
Lydia Arfianti, R. D. Haryadi
The purpose of this report was to evaluate the outcome of biofeedback muscle re-education after brachial plexus reconstruction. A case series was conducted based on registry data of Rehabilitation Outpatient Clinic. A total of 20 subjects underwent surgical reconstruction to restore elbow flexion in the period of 2012-2014 were included in the study. All 20 subjects received biofeedback muscle re-education until end June 2015 (data extraction). Oucome measures were time to recovery (months) after surgical reconstruction and patients’ compliance. Recovery is considered when muscle contraction of biceps (nerve transfer) and gracilis (free functional muscle transfer/ FFMT) are ≥ 100μV, recorded using EMG-surface electrode. Of 4 subjects underwent nerve transfer, all showed recovery with median time of 9 months. Of 16 subjects underwent FFMT, 5 showed recovery with median time of 9 months. The majority of subjects in both groups could comply with once in 2 weeks rehabilitation program.
本报告的目的是评估臂丛重建后生物反馈肌肉再教育的效果。采用康复门诊登记资料进行病例系列分析。2012-2014年共纳入20例接受手术重建恢复肘关节屈曲的患者。20例受试者均接受生物反馈肌肉再教育,至2015年6月底(数据提取)。结果测量手术重建后的恢复时间(月)和患者的依从性。肌电表面电极记录肱二头肌(神经转移)和股薄肌(自由功能肌转移/ FFMT)肌肉收缩≥100μV时考虑恢复。4例患者行神经移植,均恢复,中位时间9个月。16例患者行FFMT, 5例恢复,中位时间为9个月。两组大多数受试者均能遵守2周1次的康复计划。
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引用次数: 2
Association between Muscle Mass and Muscle Strength with Physical Performance in Elderly in Surabaya 泗水老年人肌肉质量和肌肉力量与体能表现的关系
Pub Date : 2020-02-28 DOI: 10.20473/SPMRJ.V2I1.2020.24-34
Titin Kristiana, Novira Widajanti, Rwahita Satyawati
ABSTRACTBackground: Sarcopenia is a decrease in muscle mass and strength that mostly happens in the elderly. Sarcopenia is a problem that is often found in the elderly who are at risk of disability, hospitalization and death. This data on muscle mass and strength with physical performance is expected to support the theory of sarcopenia and as a reference in promoting and preventing sarcopenia in elderly.Aims: To analyze the association between muscle mass and strength (handgrip strength) with physical performance assessed using Short Physical Performance Battery (SPPB) in an elderly community.Methods: This study was a cross-sectional observational analytic study involving 203 sample of elderly (age >60 years old). The subjects were categorized as the strong and weak muscle mass and muscle strength, also the high, moderate and low physical performance. We used Bioimpedance Analysis (BIA) and hand dynamometer to measure muscle mass and muscle strength (handgrip strength). SPPB was used to assess physical performance.The association between muscle mass and strength with physical performance was displayed in bivariate analysis with chi square.Result: Of all 203 subjects, 57 were males and 146 were females. Chi square test showed association between muscle strength (handgrip strength) with physical performance (SPPB) (p=0.001), with a weak correlation (r=0.26) and no association between muscle mass and physical performance (SPPB) (p=0.517).Conclusion: There is a positive association between muscle strength with physical performance, with a weak correlation and no association between muscle mass and physical performance in the elderly community in Surabaya.
摘要背景:肌肉减少症是一种肌肉质量和力量的减少,主要发生在老年人身上。骨骼肌减少症是一个常见于有残疾、住院和死亡风险的老年人的问题。这些肌肉质量和力量与体能表现的数据有望支持肌肉减少症理论,并为促进和预防老年人肌肉减少症提供参考。目的:分析肌肉质量、力量(握力)与运动表现(SPPB)之间的关系。方法:本研究采用横断面观察性分析研究,共纳入203例年龄>60岁的老年人。研究对象的肌肉质量和肌肉力量分为强、弱两类,体能表现分为高、中、低三类。我们使用生物阻抗分析(BIA)和手部测力仪测量肌肉质量和肌肉力量(握力)。SPPB用于评估身体机能。肌肉质量和力量与体能表现之间的关联用卡方双变量分析显示。结果:203例患者中,男性57例,女性146例。卡方检验显示,肌肉力量(握力)与体能表现(SPPB)呈正相关(p=0.001),呈弱相关(r=0.26),肌肉质量与体能表现(SPPB)无相关性(p=0.517)。结论:泗水老年人肌肉力量与体能表现呈正相关,肌肉质量与体能表现呈弱相关,不存在相关性。
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引用次数: 6
Effect of High Frequency Transcranial Magnetic Stimulation (TMS) on Extensor Digitorum Communis Muscle Strength in Ischemic Stroke Patients 高频经颅磁刺激对缺血性脑卒中患者指共伸肌肌力的影响
Pub Date : 2020-02-28 DOI: 10.20473/SPMRJ.V2I1.17014
Bastianus Alfian Juatmadja, Meisy Andriana, Rwahita Satyawati
Abstract Background: Stroke may disrupt a patient’s motor function, consequently affecting the quality of life. A stroke surviving brain has the ability to repair itself through neuroplasticity mechanism. Transcranial Magnetic Stimulation (TMS) is a non-invasive device which can be used to stimulate the lesioned part of the brain in hope of triggering neuroplasticity.Aims: To find prove of the repetitive Transcranial Magnetic Stimulation (rTMS) effect on extensor digitorum communis muscle strength improvement in ischemic stroke patients.Methods: Subjects suitable with the inclusion criteria (N=18) were divided into two groups,  control group and intervention group. The control group underwent conventional therapy exclusively every day for 5 days in a row, while the intervention group underwent rTMS therapy and conventional therapy every day for 5 days in a row. Extensor digitorum communis muscle strength was measured using surface electromyography (sEMG) before and after treatment.Result: Significant increase of sEMG numbers were found on control group (p=0,003) and intervention group (p=0,001). The increase from the intervention group was not different when compared to the control group (p=0,067).Conclusion: TMS can increase extensor digitorum communis muscle strength but with no difference with a conventional therapy.
背景:中风可能会破坏患者的运动功能,从而影响生活质量。中风后存活的大脑具有通过神经可塑性机制自我修复的能力。经颅磁刺激(Transcranial Magnetic Stimulation, TMS)是一种非侵入性的装置,可以通过刺激脑损伤部位来触发神经可塑性。目的:探讨反复经颅磁刺激(rTMS)对缺血性脑卒中患者指掌伸肌肌力的改善作用。方法:将符合纳入标准的受试者18例分为对照组和干预组。对照组每天只进行常规治疗,连续5天;干预组每天进行rTMS治疗和常规治疗,连续5天。治疗前后采用表面肌电图(sEMG)测量指共伸肌肌力。结果:对照组(p= 0.003)和干预组(p= 0.001)肌电图数量明显增加。与对照组相比,干预组的增加没有差异(p=0,067)。结论:经颅磁刺激可增加指掌伸肌肌力,但与常规疗法无显著差异。
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引用次数: 1
A Single Bout of Moderate Intensity Exercise Improves Concentration Level on Teenagers 单次中等强度运动提高青少年注意力水平
Pub Date : 2020-02-28 DOI: 10.20473/SPMRJ.V2I1.2020.1-6
Maharani Ayuputeri Wijaya, Nuniek Nugraheni Sulistiawaty, Kristanti Wanito Wigati, L. Herawati
ABSTRACTBackground: Physical exercise has a lot of benefit for health. However, the effect of cognitive function such as concentration in teenagers has yet been known.Aims: The objective of this study was to analyze the effect of a single bout or acute moderate intensity physical exercise on the level of concentration in teenagers.Methods: The subjects of this study were 32 16-18 years old teenagers, divided into two groups, control (C) and exercise (E) groups. Each group consisted of 8 boys and 8 girls. The E group did a single bout of moderate exercise using ergocycle. Physical exercise duration was 15 minutes, preceded by 5 minutes of warming up and then followed by 5 minutes of cooling down exercise. The concentration level was measured using the response period to sound stimulation (in second), measured with reaction time machine pre- and post-treatment. Faster response showed better concentration level and vice versa. Data were analyzed using paired T test, Wilcoxon Signed Ranks Test, independent T test, and Mann-Whitney test. The significance level was 5%.Result: There were significant differences of concentration level between pre- and post-exercise in E group (p= 0.004) and post-exercise concentration level between groups (p = 0.01). Exercise group had faster reaction time than C group (0.555±0.2 vs. 0.793±0.3, respectively).Conclusion: A single bout of moderate intensity exercise can improve the cognitive function showed by increased concentration level in teenagers. 
摘要背景:体育锻炼对健康有很多好处。然而,对青少年的注意力等认知功能的影响尚不清楚。目的:本研究的目的是分析单次或急性中等强度体育锻炼对青少年注意力水平的影响。方法:选取32名16 ~ 18岁的青少年为研究对象,分为对照组(C组)和运动组(E组)。每组8名男生和8名女生。E组使用ergocycle单车进行了一次中等强度的运动。体育锻炼时间为15分钟,前5分钟热身,后5分钟降温。浓度水平采用声刺激反应时间(秒)测量,反应时间机处理前后测量。反应越快,注意力越集中,反之亦然。数据分析采用配对T检验、Wilcoxon sign rank检验、独立T检验和Mann-Whitney检验。显著性水平为5%。结果:E组运动前后浓度差异有统计学意义(p= 0.004),组间运动后浓度差异有统计学意义(p= 0.01)。运动组反应时间较C组快(0.555±0.2∶0.793±0.3)。结论:单次中等强度运动可改善青少年的认知功能,表现为注意力水平的提高。
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引用次数: 2
Correlation Between Quadriceps, Hamstring, Tibialis Anterior, and Gastrocnemius Muscle Activation, With Knee Flexion Angle In Basketball Athlete While Performing Double-Leg Landing Task 篮球运动员双腿着地时,股四头肌、腘绳肌、胫骨前肌和腓肠肌活动与膝关节屈曲角度的关系
Pub Date : 2020-02-28 DOI: 10.20473/SPMRJ.V2I1.17051
D. A. Utami
ABSTRACTBackground: Anterior cruciate ligament (ACL) injury cause great disability for athlete. Recent focus of ACL injury management is on prevention by identifying the risk factors. Most of basketball injury mechanism is non-contact, related to landing process with small knee flexion angle. Muscle activation and its ratio, which control movement pattern in sagittal plane, are said to play a role in dynamic movement such as landing.Aims: The purpose of this study is to analyze the correlation between muscles activation and their activation ratio of quadriceps, hamstring, tibialis anterior and gastrocnemius with knee flexion angle of basketball athlete while performing double-leg landing task.Material and methods: This study was an observational analytic, cross sectional study. Study subjects was basketball athletes age 16 – 25 years in Surabaya. Measurements of knee flexion angle done with digital measurements of reflective marker, and muscle activation was measured with sEMG while performing double-leg landing task.Result: There was no significant correlation between maximum knee flexion angle and muscle activation of quadriceps (p=0,562), hamstring (p=0,918), tibialis anterior (p=0,394) and gastrocnemius (p=0,419). There was also no significant correlation between maximum knee flexion angle and the muscle activation ratio of quadriceps-hamstring (p=0,347), quadriceps-tibialis (p=0,139), quadriceps-gastrocnemius (p=0,626), hamstring-tibialis anterior (p=0,365), hamstring-gastrocnemius (p=0,867), and tibialis anterior-gastrocnemius (p=0,109).Conclusions: There was no correlation between muscle activation and muscle activation ratio of quadriceps, hamstring, tibialis anterior and gastrocnemius with maximum knee flexion angle in basketball athlete while performing double-leg landing task.
摘要背景:前交叉韧带(ACL)损伤对运动员造成很大的残疾。最近ACL损伤管理的重点是通过识别危险因素来预防。篮球损伤机制多为非接触性,与膝关节屈曲角度小的落地过程有关。肌肉激活及其比值控制着矢状面运动模式,据说在诸如着陆等动态运动中起着重要作用。目的:分析篮球运动员在进行双腿着地任务时,股四头肌、腘绳肌、胫前肌和腓肠肌的肌肉激活及其激活比与膝关节屈曲角度的关系。材料与方法:本研究为观察性分析、横断面研究。研究对象为泗水市16 - 25岁的篮球运动员。膝关节屈曲角度的测量采用反射标记的数字测量,肌肉活动的测量采用肌电图。结果:膝关节最大屈曲角度与股四头肌(p= 0.562)、腘绳肌(p= 0.918)、胫前肌(p= 0.394)、腓肠肌(p= 0.419)的肌肉活动无显著相关性。最大膝关节屈曲角度与股四头肌-腘绳肌(p=0,347)、股四头肌-胫肌(p=0,139)、股四头肌-腓肠肌(p=0,626)、腿筋-胫前肌(p=0,365)、腿筋-腓肠肌(p=0,867)、胫前肌-腓肠肌(p=0,109)的肌肉激活比也无显著相关性。结论:篮球运动员在进行双腿着地任务时,股四头肌、腘绳肌、胫前肌和腓肠肌的肌肉激活率与膝关节最大屈曲角度无相关性。
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引用次数: 0
Drop foot Post Mitral Valve Replacement and Total correction of Tetralogy of Fallot: A Two Case Report 跌落足后二尖瓣置换术及法洛四联症的完全矫正2例报告
Pub Date : 2019-12-24 DOI: 10.20473/spmrj.v1i2.2019.65-67
D. Poerwandari, Daisy F Lapasi, M. BayuAji
Background: Peripheral nerve lesion after heart surgery was reported on brachial plexus, phrenic nerve, laryngeal recurrent nerve facial nerve, lumbosacral root and spinal cord. Incidence of peroneal communis nerve lesion after heart surgery was not much reported (0,19%). Diagnostic procedure of peripheral nerve lesion are including clinical sign and symptom,  electrophysiology studies and MRI. Rehabilitation management of peripheral nerve lesion are not only management of pain and nerve stimulation, but also walking aid beside cardiac rehabilitation due to cardiac problem.Methods: Reporting two case of peripheral nerve lesion after heart surgery. First case is a female, 37 years old suffered from drop foot two days after mitral valve replacement with mechanic valve. She got pain management, electrical nerve stimulation and therapeutic exercise beside cardiac rehabilitation program. Second case is a female, 9 years old, after total correction of Tetralogy of Fallot, got drop foot at day two. She also got pain management, electrical nerve stimulation and therapeutic exercise beside cardiac rehabilitation.Results: First case result was the drop foot getting better after she entered phase two of cardiac rehabilitation. In the second case, the drop foot was relieved at phase two cardiac rehabilitation and back to normal condition after one year after surgery.Conclusion: In these two case of drop foot after heart surgery, the drop foot was relieved after pain and rehabilitation management beside cardiac rehabilitation.
背景:报道了心脏手术后周围神经病变,包括臂丛神经、膈神经、喉返神经、面神经、腰骶神经根和脊髓。心脏手术后腓共神经损伤的发生率报道不多(0.19%)。周围神经病变的诊断程序包括临床体征和症状、电生理检查和MRI检查。周围神经病变的康复管理不仅包括疼痛和神经刺激的管理,还包括心脏问题引起的心脏康复之外的助行管理。方法:报告2例心脏手术后周围神经损伤。首例患者为女性,37岁,机械二尖瓣置换术后2天出现坠足。除心脏康复外,她还接受了疼痛管理、神经电刺激和治疗性运动。第二例为女性,9岁,法洛四联症完全矫正后,于第2天落下足。除了心脏康复外,她还接受了疼痛管理、神经电刺激和治疗性运动。结果:1例患者进入心脏康复二期后,下垂足逐渐好转。第二例患者在心脏康复二期解除下垂足,术后一年后恢复正常。结论:2例心脏手术后下垂足均经疼痛及心脏康复治疗后下垂足得到缓解。
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引用次数: 0
The Relationship Between Quadriceps Muscle Atrophy and Proprioception Function in Knee Osteoarthritis Patients 膝关节骨性关节炎患者股四头肌萎缩与本体感觉功能的关系
Pub Date : 2019-12-24 DOI: 10.20473/spmrj.v1i2.2019.59-64
Ayuni Susanti, Rr. Indrayuni Lukitra Wardhani, I. P. A. Pawana
Background: Osteoarthritis of the knee (OA) patients can experience impaired proprioceptive function which causes instability, balance disorder and limited activity. Further analysis is needed to detect changes that occur. There are two methods to evaluate the speed and angle of a particular motion as an analysis of the function of proprioception, Time to Detect Passive Movements (TTDPM) and Joint Position Sense (JPS).Aim: To analyze the relationship between quadriceps muscle atrophy with proprioception in knee osteoarthritis patients.Methods: The design of this research is cross sectional analysis done in Dr. Soetomo General Hospital Surabaya, Indonesia. There were 25 knee OA patients (2 men and 23 women) with each subject had proprioception (JPS and TTDPM) function measured using isokinetics dynamometer on both sides of the knee.Results: This study shows the atrophic side had greater pain intensity and greater disturbance of proprioception. In addition, there were significant differences in JPS measurements at  angle of 30⁰, and 60⁰ and TTDPM (p <0.05). No difference obtained at 45⁰ measurements angle.Conclusion: In this study, there was no association between quadriceps atrophy and function of proprioception in knee osteoarthritis patients. This was due to a number of confounding factors that cannot be controlled such as duration, difference in pain intensity, OA severity, physical activity before measurement, and fatigue which can affect proprioception function and bring misinterpretation on measurements.
背景:膝关节骨关节炎(OA)患者可经历本体感觉功能受损,导致不稳定、平衡障碍和活动受限。需要进一步的分析来检测发生的变化。有两种方法可以评估特定运动的速度和角度,作为本体感觉功能的分析,即被动运动检测时间(TTDPM)和关节位置感(JPS)。目的:分析膝关节骨性关节炎患者股四头肌萎缩与本体感觉的关系。方法:本研究的设计是在印度尼西亚泗水Soetomo博士综合医院进行的横断面分析。25例膝关节OA患者(男2例,女23例)均采用双侧膝关节等速测力仪测量本体感觉(JPS和TTDPM)功能。结果:萎缩侧疼痛强度大,本体感觉障碍大。此外,JPS测量在30⁰、60⁰和TTDPM处存在显著差异(p <0.05)。在45⁰测量角度没有得到差异。结论:在本研究中,膝关节骨性关节炎患者的股四头肌萎缩与本体感觉功能无相关性。这是由于一些无法控制的混杂因素,如持续时间、疼痛强度差异、OA严重程度、测量前的身体活动和疲劳,这些因素会影响本体感觉功能并对测量结果产生误解。
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引用次数: 2
Comparison of Acute Level of CK After Five Weeks Eccentric vs Concentric High Intensity Strength Exercise in Healthy Subject 健康受试者离心与同心高强度力量运动后5周急性期CK水平的比较
Pub Date : 2019-12-24 DOI: 10.20473/spmrj.v1i2.2019.38-43
Hasni Hasni, Hening Laswati Putra, Nuniek Nugraheni
Background: Musculoskeletal injuries both in sport and recreational activities, at each age level, can lead to immobilization. Injury and immobilization can lead to muscle strength decrease and deconditioning. These conditions can be addressed by provision of strength training therapy especially for people with low exercise tolerance such as the elderly and patients with chronic disease. Existing studies stated eccentric exercise can increase muscle strength with less energy expenditure compared to concentric exercise. However eccentric exercise can lead to muscle damage indicated with an acute CK level increase, and eccentric exercise has not been carried out regularly for post muscle injuries and deconditioned patients. The American College of Sport Medicine (ACSM) stated strength increase and muscle hypertrophy require high intensity load strengthening exercise with a minimum load of 70% 1 Maximum Repetition. The recommended load was given to the subjects in this research. Our pleriminary study intervention was well tolerated by healthy subjects.Aim: Comparing acute CK level alteration in high intensity eccentric and concentric muscle strengthening exercise on untrained healthy subjects.Methods: Randomized pre test and post test group design. Subjects of the study (n = 16) were untrained healthy males. CK level was evaluated by laboratory test.Results: Our study showed decline of acute CK level in both groups with p value 0.65 and 0.76, respectively. No significant differences found on both groups.Conclusion: The increase of acute CK level after five weeks of eccentric strengthening exercise is not higher than that in concentric strengthening exercise.
背景:运动和娱乐活动中的肌肉骨骼损伤,在每个年龄段都可能导致固定。损伤和固定可导致肌肉力量下降和去适应。这些情况可以通过提供力量训练疗法来解决,特别是对于运动耐受性低的人,如老年人和慢性病患者。现有的研究表明,与同心运动相比,离心运动可以在消耗较少能量的情况下增加肌肉力量。然而,偏心运动可导致肌肉损伤,表现为急性CK水平升高,而在肌肉损伤后和失能患者中,偏心运动并未定期进行。美国运动医学学院(ACSM)指出,力量增加和肌肉肥大需要高强度负荷强化运动,最小负荷为70% 1最大重复。本研究给予受试者推荐负荷。我们的初步研究干预在健康受试者中耐受良好。目的:比较未经训练的健康人在高强度偏心肌和同心肌强化运动中CK水平的变化。方法:随机分组设计。研究对象(n = 16)为未经训练的健康男性。通过室内试验评价CK水平。结果:我们的研究显示两组急性CK水平下降,p值分别为0.65和0.76。两组间无显著差异。结论:离心强化运动5周后急性CK水平的升高不高于同心强化运动。
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引用次数: 2
Does Treadmill Training Improve Balance Function of Healthy Untrained Young Adult Male? 跑步机训练能改善未训练的健康成年男性的平衡功能吗?
Pub Date : 2019-12-24 DOI: 10.20473/spmrj.v1i2.2019.44-51
S. Theodora, D. Tinduh, Rr. Indrayuni Lukitra Wardhani
Background: Number of falls increase among elders and young adults prior to any cause. Occult balance disorder may become one of the morbidity factors that causes fall in young adults and eventually elders. One leg stance test reflects static balance function that might show occult balance disorder in healthy population. Closed eyes crossed arms one leg stance (CECAOLS) used to eliminate balance factors such as visual and arms sways that can elevate limit of stability (LOS). Treadmill used as a dynamic balance exercise with inclination and speed level as its’ component to challenge the balance function.Aim: to compare CECAOLS value in subjects with gradual increase of speed versus inclination in moderate intensity treadmill exercise.Methods: Nineteen healthy young adults male with sedentary lifestyle aged from 26 to 37 years old were recruited. Nine people in inclination group, ten people in speed group. Treadmill exercise with moderate intensity (70% maximal heart rate), exercise duration was 30 minutes (5 minutes warming up, 20 minutes core exercise, 5 minutes cooling down), 3 times/week, for 4 weeks. Measurement of CECAOLS value were done prior to first exercise and after completion of exercise in 4th week.Results: Significant increase of CECAOLS value at right leg inclination group with p=0.038. No significant increase of CECAOLS value in speed group (p>0.05).Conclusion: Moderate intensity treadmill exercise with gradual inclination increase 30 minutes duration, 3 times/week, for 4 week was proven to increase CECAOLS value in young adult healthy untrained male.
背景:在任何原因之前,老年人和年轻人的跌倒数量增加。隐蔽性平衡障碍可能成为导致年轻人甚至老年人跌倒的发病因素之一。单腿站立测试反映静态平衡功能,可能显示健康人群的隐性平衡障碍。闭眼双臂交叉一腿站立(CECAOLS)用于消除视觉和手臂摆动等平衡因素,这些因素会提高稳定极限(LOS)。跑步机作为一种动态平衡运动,以倾斜和速度水平为其组成部分,挑战平衡功能。目的:比较中等强度跑步机运动中速度和倾斜度逐渐增加的受试者的CECAOLS值。方法:招募了19名年龄在26 ~ 37岁、有久坐生活方式的健康年轻男性。倾斜组九个人,速度组十个人。中等强度(70%最大心率)的跑步机运动,运动时间为30分钟(5分钟热身,20分钟核心运动,5分钟冷却),每周3次,连续4周。在第一次运动前和第4周运动结束后分别测量CECAOLS值。结果:右腿倾斜组CECAOLS值显著升高,p=0.038。速度组CECAOLS值无显著升高(p>0.05)。结论:中等强度、坡度逐渐增加的跑步机运动30分钟,3次/周,连续4周,可提高青年健康未训练男性的CECAOLS值。
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引用次数: 2
Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats 中等强度体育锻炼增加链脲佐菌素诱导糖尿病大鼠朗格汉斯胰岛Β (Β)细胞和大小
Pub Date : 2019-12-24 DOI: 10.20473/SPMRJ.V1I2.2019.52-58
Sarah M Nurdin, Nuniek Nugraheni, Mei Wulan
Background: The death of β cells Langerhans islets in Diabetes Mellitus (DM) can cause  loss of Langerhans islet function and worsen the progression of DM. Physical exercise plays a major part in DM treatment.Aim: to observe the effect of moderate intensity exercise to β (beta) cell numbers and Langerhans islets area size in Streptozotocin (STZ) induced diabetes in rats.Methods: Thirty adult male Wistar rats (Rattusnorvegicus) divided into 3, Group 1 as the control, Group 2 received 35 mg/kg streptozotocin induction treatment, Group 3 received 35 mg/kg streptozotocin induction and physical exercise, swimming, with moderate intensity 70% from the swimming maximal ability, 9% of body weight load, 4 times a week for 4 weeks. Datas collected were in the form of histopathology slide of pancreatic tissue after receiving treatment for 28 days.Results: There are significant differences of β-cell pancreas number between group K1 and K2 (p<0,001), group K2 and to K3 (p<0,001). No significant difference between group K1 and K3 (p=0,102). The Langerhans islets area sizes of pancreas tissue between group K1, K2, and K3 are significantly different (p<0,001).Conclusion: This study shows moderate-intensity physical exercise can increase the number of β cell and average area size of Langerhans islets. The effect of physical exercise depends on the intensity of exercise and the capacity of pancreatic function left of the diabetic.
背景:糖尿病(DM)患者朗格汉斯胰岛β细胞死亡可导致朗格汉斯胰岛功能丧失,加重糖尿病的进展,体育锻炼在糖尿病治疗中起重要作用。目的:观察中等强度运动对链脲佐菌素(STZ)诱导的糖尿病大鼠β (β)细胞数量和朗格汉斯岛面积大小的影响。方法:30只成年雄性Wistar大鼠(褐家鼠)分为3只,第1组为对照,第2组给予35 mg/kg链脲佐菌素诱导治疗,第3组给予35 mg/kg链脲佐菌素诱导并进行体育锻炼、游泳,强度为游泳最大能力的70%,体重负荷的9%,每周4次,连续4周。治疗28天后,以胰腺组织病理切片的形式收集数据。结果:K1组与K2组胰腺β细胞数量差异有统计学意义(p< 0.001), K2组与K3组胰腺β细胞数量差异有统计学意义(p< 0.001)。K1组与K3组间差异无统计学意义(p=0,102)。K1、K2、K3组胰腺组织朗格汉斯胰岛面积差异有统计学意义(p< 0.001)。结论:中等强度体育锻炼可增加朗格汉斯胰岛β细胞数量和平均面积大小。体育锻炼的效果取决于运动强度和糖尿病患者的胰腺功能剩余能力。
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引用次数: 1
期刊
Surabaya Physical Medicine and Rehabilitation Journal
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