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Science Communication: A basic skill that needs to be developed in undergraduate and graduate programs 科学传播:在本科和研究生课程中需要培养的基本技能
Pub Date : 2021-11-30 DOI: 10.15173/sciential.vi7.2922
David Rodrigues
Communication skills are one of the most widely recognized learning outcomes for numerous programs in higher education. However, proper training in science communication skills are consistently falling short of requirements. This highlights the need to examine the curriculum as a whole as opposed to a course level view. In this piece, I present arguments expressing the need for proper incorporation of formal communication training in undergraduate and graduate programs to enhance the quality of discourse between scientists and the lay public. Specifically, this opinion piece briefly describes the current state of SciComm training and the lack of core skills in existing courses, the essence of science communication and teaching, and its impact in the workplace.
沟通技巧是高等教育中众多课程中最广泛认可的学习成果之一。然而,科学传播技能的适当培训始终达不到要求。这强调了从整体上考察课程的必要性,而不是从课程层次上考察。在这篇文章中,我提出了一些观点,表达了在本科和研究生课程中适当纳入正式沟通培训的必要性,以提高科学家和普通公众之间的对话质量。具体来说,这篇评论文章简要描述了科学传播培训的现状和现有课程中缺乏的核心技能,科学传播和教学的本质,以及它在工作场所的影响。
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引用次数: 1
Origins of Life 生命的起源
Pub Date : 2020-03-31 DOI: 10.15173/sciential.v1i4.2241
Hannah Mahoney
When, where, and how did life on Earth originate? The origin of life problem involves multiple scientific disciplines and has spanned multiple decades. It can be summarized into three stages: (1) the origin of biological monomers, (2) the origin of biological polymers, and (3) the emergence and evolution of cells. While highly speculative, the connections between these stages are theorized by attempting to determine the geochemical situations which could have driven chemical evolution and allow for the emergence of specific chemical functions of biological systems. This review summarizes reported findings relevant to the early Earth environment and the main theories in the origin of life subject. Specific focus is placed on the metabolism first, RNA world, and compartmentalization first theories as they are involved in the origin of life paradox. The review then discusses submarine hydrothermal vents as a possible location for which life could have occurred. Understanding of information pertaining to the origin of life is important as it allows for advancement and discoveries in other fields of science and medicine. Overall, the aim of this review is to display the relevant information about the origin of life theory and highlight the importance of future research.
地球上的生命是何时、何地、如何起源的?生命的起源问题涉及多个科学学科,已经跨越了几十年。它可以概括为三个阶段:(1)生物单体的起源,(2)生物聚合物的起源,(3)细胞的出现和进化。虽然这些阶段之间的联系是高度推测性的,但通过试图确定可能推动化学进化并允许生物系统出现特定化学功能的地球化学情况,可以将这些阶段之间的联系理论化。本文综述了有关早期地球环境的研究成果和生命起源的主要理论。具体的重点放在新陈代谢第一,RNA世界,和划分第一理论,因为它们涉及到生命起源悖论。然后,这篇综述讨论了海底热液喷口作为生命可能发生的地点。了解有关生命起源的信息是很重要的,因为它允许在其他科学和医学领域的进步和发现。总的来说,这篇综述的目的是展示生命起源理论的相关信息,并强调未来研究的重要性。
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引用次数: 0
COVID-19
Pub Date : 2020-03-31 DOI: 10.15173/sciential.v1i4.2439
Youssef El-Sayes
A new strain of coronavirus termed 2019-nCoV or 2019 new coronavirus was discovered in December 2019 and initiated in Wuhan, Hubei province, China1. The virus has infected over 75,000 individuals as of February 20202.
2019年12月,在中国湖北省武汉市发现了一种名为2019- ncov或2019新型冠状病毒的新型冠状病毒株。截至2020年2月,该病毒已感染75000多人。
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引用次数: 0
Alternative Treatment for Alzheimer’s Disease: Porphyromonas gingivalis Inhibitors 阿尔茨海默病的替代治疗:牙龈卟啉单胞菌抑制剂
Pub Date : 2019-11-29 DOI: 10.15173/sciential.v1i3.2251
Pouriya Sadeghighazichaki
Porphyromonas gingivalis (P. gingivalis), has been identified as a primary pathogen in causing chronic periodontitis, or gum inflammation. P. gingivalis was also isolated in brain samples of patients suffering from Alzheimer’s disease. A virulence factor of P. gingivalis called gingipains, releases proteases responsible for neurodegeneration and has been identified in the brain of patients suffering from Alzheimer’s. Studies show that mice infected with P. gingivalis demonstrate an increase in amyloid plaque deposition in brain samples. Further investigation identified gingipains as a neurotoxic agent, both in vivo and in vitro, which impacts the structure of tau protein, responsible for the normal functioning of neurons. Small-molecule inhibitors targeting gingipains are utilized to prevent the neurotoxic effects of gingipains and facilitate neuronal regeneration. Inhibition of this virulence factor reduced the overall bacterial load, blocked amyloid-beta production, prevented neuroinflammation, and allowed for neuronal recovery. These findings provide a new outlook for the onset of Alzheimer’s disease and elucidate a much-needed potential treatment for the condition.
牙龈卟啉单胞菌(P. gingivalis)已被确定为引起慢性牙周炎或牙龈炎症的主要病原体。在阿尔茨海默病患者的脑样本中也分离到了牙龈卟啉卟啉菌。一种叫做gingipains的牙龈卟啉卟啉毒力因子,释放导致神经变性的蛋白酶,已经在患有阿尔茨海默氏症的患者的大脑中被发现。研究表明,感染牙龈卟啉卟啉菌的小鼠大脑样本中淀粉样斑块沉积增加。进一步的研究发现,无论是体内还是体外,牙龈痛都是一种神经毒性物质,它会影响tau蛋白的结构,而tau蛋白负责神经元的正常功能。针对牙龈痛的小分子抑制剂被用于预防牙龈痛的神经毒性作用和促进神经元再生。这种毒力因子的抑制降低了总体细菌负荷,阻断了淀粉样蛋白的产生,防止了神经炎症,并允许神经元恢复。这些发现为阿尔茨海默病的发病提供了新的前景,并阐明了急需的潜在治疗方法。
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引用次数: 1
Determining the Rate of Development of Antibiotic Resistance to Streptomycin and Doxycycline in Escherichia coli 大肠埃希菌对链霉素和强力霉素耐药率的测定
Pub Date : 2019-11-29 DOI: 10.15173/sciential.v1i3.2265
D. Tertigas, Gemma Barber
Antibiotic resistance is a pressing issue in the medical field today. It is important to understand the development of bacterial resistance to implement effective preventative measures against antibiotic resistant bacteria. This study investigated the rate at which Escherichia coli (E. coli), a common pathogen, developed resistance to streptomycin and doxycycline, as Oz et al. (2014) showed differing levels of resistance in E. coli to these two antibiotics. The development of antibiotic resistance was measured by adding E. coli to 96-well plates in the presence of increasing doses of doxycycline, streptomycin, or a combination treatment. Successive generations were added to the same treatments to see whether they would grow at higher concentrations of antibiotic. The change in minimum inhibitory concentration for streptomycin and doxycycline was determined as the bacteria became increasingly resistant to each antibiotic. The fastest rate of antibiotic resistance was observed for streptomycin, with doxycycline resistance exhibiting a slower rate of development. The rate of resistance development for the combination treatment was the slowest, potentially due to small differences in target domains. Some cross-resistance was also observed. This study provides a small-scale methodological basis and preliminary insight on antibiotic resistance trends for two antibiotic classes and a combination treatment.
抗生素耐药性是当今医学领域的一个紧迫问题。了解细菌耐药性的发展,对有效预防耐药菌具有重要意义。本研究调查了常见病原体大肠杆菌(大肠杆菌)对链霉素和强力霉素产生耐药性的速度,因为Oz等人(2014)显示大肠杆菌对这两种抗生素的耐药程度不同。通过将大肠杆菌添加到96孔板中,增加强力霉素、链霉素或联合治疗的剂量,来测量抗生素耐药性的发展。连续几代被添加到相同的处理中,以观察它们是否会在更高浓度的抗生素下生长。细菌对链霉素和强力霉素的最低抑制浓度的变化是确定的,因为细菌对每种抗生素的耐药性越来越强。链霉素的耐药速度最快,多西环素的耐药速度较慢。联合治疗的耐药发展速度是最慢的,可能是由于靶域的微小差异。还观察到一些交叉阻力。本研究提供了一个小规模的方法学基础,并初步了解了两类抗生素和联合治疗的抗生素耐药趋势。
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引用次数: 3
History, Present, and Future of Age-Related Cataracts Surgery 老年性白内障手术的历史、现在和未来
Pub Date : 2019-11-29 DOI: 10.15173/sciential.v1i3.2225
Suhaila Abdelhalim, Lyan Abdul Majeed Abdul Wadood
Twenty years ago, WHO and IAPB introduced an initiative called ‘The Right to Sight’, which set out to eliminate avoidable blindness universally by 2020. Age-related cataracts is a major contributor to treatable blindness worldwide and is increasing in global prevalence due to the growing proportion of individuals over 65 years of age. Cataracts refers to opacification of the lens inside the eye and clinically presents as a painless blurring and clouding of vision. From couching operations in 1200 B.C. to modern phacoemulsification, different approaches have been used to tackle this ancient disease over the centuries. Treatment today mainly involves surgery to replace the opaque lens with an artificial intraocular lens. Cutting-edge research into future therapies include investigating accommodating intraocular lenses, which hope to postoperatively restore accommodation. With the target year 2020 approaching, it is necessary to initiate discussion on age-related cataracts. This paper will provide a brief overview of this disease, discuss developments in treatment, and review innovations currently being pursued in the field.
20年前,世卫组织和IAPB提出了一项名为“视力权利”的倡议,旨在到2020年普遍消除可避免盲症。年龄相关性白内障是世界范围内可治疗失明的一个主要原因,由于65岁以上个体的比例不断增加,全球患病率正在上升。白内障是指眼内晶状体混浊,临床上表现为无痛性视力模糊和浑浊。从公元前1200年的手术到现代的超声乳化术,几个世纪以来,人们采用了不同的方法来治疗这种古老的疾病。目前的治疗主要包括手术用人工人工晶状体代替不透明晶状体。未来治疗的前沿研究包括研究可调节的人工晶状体,希望在术后恢复可调节性。随着2020年目标的临近,有必要对老年性白内障展开讨论。本文将简要概述这种疾病,讨论治疗的发展,并回顾目前在该领域正在进行的创新。
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引用次数: 0
Considerations for Chemotherapy Treatment in Platinum Resistant High-Grade Serous Ovarian Cancer 耐铂高级别浆液性卵巢癌化疗的考虑
Pub Date : 2019-11-29 DOI: 10.15173/sciential.v1i3.2244
C. Reintjes
Ovarian cancer is considered to be the most fatal type of any gynecological cancer. Prognosis for the disease is poor, with a median survival of only thirty-two months following diagnosis and a five-year survival rate of only 39%. Many of the most lethal ovarian cancer cases are classified as part of the high-grade serous ovarian cancer (HGSOC) subtype, which is the most aggressive form of the disease. The primary concern with regards to treatment is that nearly 30% of patients will develop a resistance to forms of platinum chemotherapy, which is the main method of treatment. This suggests that a one-size fits all approach cannot be taken to treat ovarian cancer, and that further research must be done to understand how to treat the patients who present with platinum resistance. This literature review examines the mutations within two susceptible loci, specifically, the p53 and BRCA1/2 genes, in order to understand how platinum resistance develops and why it is present in some patients. The objectives of this review are  to characterize the underlying genetic mechanisms affecting platinum resistance, specify the biomarkers associated with those mechanisms, and describe alternative methods for approaching the treatment of ovarian cancer on an individual scale.
卵巢癌被认为是妇科癌症中最致命的一种。该疾病的预后很差,诊断后中位生存期仅为32个月,5年生存率仅为39%。许多最致命的卵巢癌病例被归类为高级别浆液性卵巢癌(HGSOC)亚型的一部分,这是该疾病最具侵袭性的形式。治疗方面的主要问题是,近30%的患者将对主要治疗方法铂类化疗产生耐药性。这表明不能采取一刀切的方法来治疗卵巢癌,必须进行进一步的研究以了解如何治疗出现铂耐药的患者。本文献综述检查了两个易感基因位点的突变,特别是p53和BRCA1/2基因,以了解铂耐药是如何发展的以及为什么它存在于一些患者中。本综述的目的是描述影响铂耐药的潜在遗传机制,指定与这些机制相关的生物标志物,并描述在个体范围内接近卵巢癌治疗的替代方法。
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引用次数: 0
Diagnosing Disorders of Consciousness 诊断意识障碍
Pub Date : 2019-03-29 DOI: 10.15173/sciential.v1i2.2099
Netri Pajankar
The definition of consciousness has long been debated in a scientific and philosophical context due to its ambiguous nature. Recent developments in the concept of consciousness have contributed to a better understanding of associated Disorders of Consciousness (DOC). However, there has not been an equivalent rise in the accuracy of diagnostic measures for DOC. About half of the patients with DOC are incorrectly diagnosed due to significant reliance on subjective and inaccurate behavioural scales. Consequently, the misrepresentation of a patient’s present residual consciousness severely affects the treatment and rehabilitation measures that they receive. These inaccurate diagnoses ultimately influence the patient’s chance of survival. Thus, it is necessary to critique the current methods of evaluating consciousness. Neurophysiological scales are explored as a possible alternative method of evaluating consciousness, which is characterized by high sensitivity and objectivity. An understanding of the advantages and disadvantages of different consciousness-evaluating techniques can aid in the advocacy of their widespread use for DOC patients.
意识的定义由于其模棱两可的性质,在科学和哲学背景下一直存在争议。意识概念的最新发展有助于更好地理解相关的意识障碍(DOC)。然而,在DOC诊断措施的准确性方面并没有相应的提高。由于严重依赖主观和不准确的行为量表,大约一半的DOC患者被错误诊断。因此,病人目前残余意识的错误陈述严重影响了他们接受的治疗和康复措施。这些不准确的诊断最终会影响患者的生存机会。因此,有必要对目前评价意识的方法进行批判。神经生理量表具有高度的敏感性和客观性,是评估意识的一种可能的替代方法。了解不同意识评估技术的优缺点,有助于倡导在DOC患者中广泛使用这些技术。
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引用次数: 0
Immortal Hydra as a Model Organism for Metal Toxicity Studies 水螅作为金属毒性研究的模式生物
Pub Date : 2019-03-29 DOI: 10.15173/sciential.v1i2.2136
Alice Nykolay, Aiman Shahid
Toxicology is an interdisciplinary scientific field that explores the impact, epidemiology, and treatment regimens for exposure to various toxic compounds and elements. Many toxicants such as metals have not yet been comprehensively examined, and a plethora of metal-related conditions are currently untreatable. Hydra is an immortal freshwater organism that serves as an excellent model for toxicity studies due to its natural availability, anatomical simplicity, yet comparatively complex physiology. This review will examine the significance of hydra toxicity studies, outline current experimental designs, as well as summarize the most commonly tested metals. Altogether, comprehensive toxicity studies on Hydra might provide promising breakthroughs in the understanding of toxicity-related physiology, and can be applied to clinical research and practice to ultimately improve health and wellbeing of those affected by metal-related disorders.
毒理学是一个跨学科的科学领域,它探索暴露于各种有毒化合物和元素的影响、流行病学和治疗方案。许多有毒物质,如金属,尚未得到全面的检查,过多的金属相关的条件,目前是无法治疗的。九头蛇是一种不朽的淡水生物,由于其自然可用性,解剖简单,但生理相对复杂,因此可以作为毒性研究的绝佳模型。本综述将探讨水螅毒性研究的意义,概述当前的实验设计,以及总结最常用的测试金属。总之,对九头蛇的综合毒性研究可能为理解毒性相关生理学提供有希望的突破,并可应用于临床研究和实践,最终改善受金属相关疾病影响的人们的健康和福祉。
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引用次数: 0
Artificial Intelligence Can Improve the Healthcare System 人工智能可以改善医疗保健系统
Pub Date : 2019-03-29 DOI: 10.15173/sciential.v1i2.2097
A. Kuganesan
Artificial intelligence (AI) is a computer system used to model human cognitive functions, intelligence, and behaviour. Components include both, a virtual and a physical aspect. Virtual aspects of AI include algorithms and neural networks instilled within the system to execute its assignments. Physical components include the entity in conjunction with a code. 1 AI is currently being developed by Nvidia Corporation, Alphabet, Twilio, Amazon, Micron Technology, Microsoft Corp., Baidu, Intel Corp., Facebook, and Tencent. 2 Expanding AI into the health care system can be beneficial for preventative care, patient safety, and reducing treatment costs for families. AI has proven to be useful in machine learning, thus, it can be programmed to complete specific tasks. By performing tasks such as data interpretation, the amount of time that it takes for a physician to consult patients regarding their results will be reduced. In addition, AI is capable of analyzing medical images to identify tumours and it has previously been used in various other branches of medicine such as neurology and cardiology. Overall, AI has great potential to improve the health care industry in North America and worldwide. However, potential violations while utilizing personal patient data must be addressed whilst modifying this technology.
人工智能(AI)是一种用于模拟人类认知功能、智能和行为的计算机系统。组件包括虚拟方面和物理方面。人工智能的虚拟方面包括系统内灌输的算法和神经网络,以执行其任务。物理组件包括实体和代码。目前,英伟达公司、Alphabet、Twilio、亚马逊、美光科技、微软公司、百度、英特尔公司、Facebook和腾讯都在开发人工智能。2将人工智能扩展到医疗保健系统中,有助于预防保健、患者安全,并降低家庭的治疗成本。人工智能已经被证明在机器学习中很有用,因此,它可以被编程来完成特定的任务。通过执行数据解释等任务,医生就其结果咨询患者所需的时间将减少。此外,人工智能能够分析医学图像以识别肿瘤,并且以前已用于神经病学和心脏病学等其他医学分支。总的来说,人工智能在改善北美和全球的医疗保健行业方面具有巨大的潜力。然而,在使用患者个人数据时,必须在修改该技术时解决潜在的违规行为。
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引用次数: 0
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Sciential - McMaster Undergraduate Science Journal
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