Hetakshi V. Patil, Mansi A. Dhankani, Amitkumar R. Dhankani
: The purpose of this review is to delve into the essence of Annona muricata Linn. A. muricata , also known as soursop, guanabana, and graviola, is a member of the Annonaceae family and has a long history of traditional uses. This is an evergreen plant that grows in the tropical and subtropical regions of the world, primarily in Africa, South America, and Southeast Asia. The medicinal properties of the A. muricata plant are a blessing for humanity, and it has been widely used in folk medicine. A. muricata preparations on the market include candies, syrups, beverages, ice creams, and shakes. Several studies have concluded that the plant contains over 212 chemical constituents such as acetogenins, alkaloids, and phenols. The plant has antibacterial, antiviral, antifungal, antitumor, anthelminthic, analgesic, antiarthritic, hypotensive, anti-inflammatory, and immune-enhancing effects, as well as anti-diabetic activity. Although some toxicities have been reported, the extract of A. muricata has been found to be effective and safe. This review attempts to bring together the majority of the available information on A. muricata ’s phytochemistry, traditional uses, biological activities, and toxicity.
{"title":"A Review on Marvel Fruit: Annona muricata","authors":"Hetakshi V. Patil, Mansi A. Dhankani, Amitkumar R. Dhankani","doi":"10.3390/ecb2023-14355","DOIUrl":"https://doi.org/10.3390/ecb2023-14355","url":null,"abstract":": The purpose of this review is to delve into the essence of Annona muricata Linn. A. muricata , also known as soursop, guanabana, and graviola, is a member of the Annonaceae family and has a long history of traditional uses. This is an evergreen plant that grows in the tropical and subtropical regions of the world, primarily in Africa, South America, and Southeast Asia. The medicinal properties of the A. muricata plant are a blessing for humanity, and it has been widely used in folk medicine. A. muricata preparations on the market include candies, syrups, beverages, ice creams, and shakes. Several studies have concluded that the plant contains over 212 chemical constituents such as acetogenins, alkaloids, and phenols. The plant has antibacterial, antiviral, antifungal, antitumor, anthelminthic, analgesic, antiarthritic, hypotensive, anti-inflammatory, and immune-enhancing effects, as well as anti-diabetic activity. Although some toxicities have been reported, the extract of A. muricata has been found to be effective and safe. This review attempts to bring together the majority of the available information on A. muricata ’s phytochemistry, traditional uses, biological activities, and toxicity.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116462345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahesh R. Doifode, Ashitosh S. Hosamani, D. Dasgupta, Prerona Boruah, M. Parab, Pramodkumar P. Gupta
: Mangrove is an opulent and untapped ecosystem with great phytochemical diversity, making it suitable for the discovery of novel antimicrobial compounds. The goal of the study was to explore the pharmaceutical antibacterial and antioxidant resources from Bruguiera gymnorrhiza , Ceriops tagal , Rhizophora mucronata and Aegiceras corniculatum and gain insight into the diversity and novelty of compounds such as alkaloids, flavanol, polyphenols etc. A liquid extract was obtained by subjecting fresh mangrove leaves to maceration and Soxhlet extraction. Plant DNA barcoding was utilized to authenticate the identity of the samples under study. A few of the obtained sequences have been communicated to GenBank (OQ696049.1, OQ696050.1, OQ692575.1, OQ679419.1). The phytochemical profiling revealed the presence of polyphenols (TPC = 8.71, 8.51, 8.77 and 5.52 mg/gm of plant tissue, respectively); flavonoids (TFC = 12.42, 8.48, 5.26 and 13.903 mg/gm of plant tissue, respectively); and alkaloids (2.5, 3.81, 4.98 and 5.21 mg/gm of plant tissue, respectively). The antioxidant potential (radical scavenging activity) was scored to be 87.8%, 89.5%, 92.07% and 45.8% (DPPH assay was conducted), respectively. The antimicrobial analysis was performed on Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae and Bacillus subtilis . The MIC revealed maximum activity in Klebsiella pneumonia , while negligible activity was scored for Staphylococcus aureus and Escherichia coli . The analysis thus reveals that the plants under study may have better medicinal activity against respiratory tract organisms. In vitro biochemical analysis of different molecules present in the plants was performed using the Swiss ADME database. The present study thus reveals the preliminary compounds from selected mangrove plants that can be promising future anti-microbial therapeutics.
{"title":"Profiling of Antibacterial Compounds from Selective Medicinal Mangrove Species","authors":"Mahesh R. Doifode, Ashitosh S. Hosamani, D. Dasgupta, Prerona Boruah, M. Parab, Pramodkumar P. Gupta","doi":"10.3390/ecb2023-14357","DOIUrl":"https://doi.org/10.3390/ecb2023-14357","url":null,"abstract":": Mangrove is an opulent and untapped ecosystem with great phytochemical diversity, making it suitable for the discovery of novel antimicrobial compounds. The goal of the study was to explore the pharmaceutical antibacterial and antioxidant resources from Bruguiera gymnorrhiza , Ceriops tagal , Rhizophora mucronata and Aegiceras corniculatum and gain insight into the diversity and novelty of compounds such as alkaloids, flavanol, polyphenols etc. A liquid extract was obtained by subjecting fresh mangrove leaves to maceration and Soxhlet extraction. Plant DNA barcoding was utilized to authenticate the identity of the samples under study. A few of the obtained sequences have been communicated to GenBank (OQ696049.1, OQ696050.1, OQ692575.1, OQ679419.1). The phytochemical profiling revealed the presence of polyphenols (TPC = 8.71, 8.51, 8.77 and 5.52 mg/gm of plant tissue, respectively); flavonoids (TFC = 12.42, 8.48, 5.26 and 13.903 mg/gm of plant tissue, respectively); and alkaloids (2.5, 3.81, 4.98 and 5.21 mg/gm of plant tissue, respectively). The antioxidant potential (radical scavenging activity) was scored to be 87.8%, 89.5%, 92.07% and 45.8% (DPPH assay was conducted), respectively. The antimicrobial analysis was performed on Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae and Bacillus subtilis . The MIC revealed maximum activity in Klebsiella pneumonia , while negligible activity was scored for Staphylococcus aureus and Escherichia coli . The analysis thus reveals that the plants under study may have better medicinal activity against respiratory tract organisms. In vitro biochemical analysis of different molecules present in the plants was performed using the Swiss ADME database. The present study thus reveals the preliminary compounds from selected mangrove plants that can be promising future anti-microbial therapeutics.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124022100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: In the world of data, there is an urgent need to find ways to extract knowledge and information for improving patient care. Artificial intelligence (AI) is an emerging tool that has the potential to provide cardiologists with new insights and knowledge. The healthcare industry has already begun the digital transformation of vast reams of data (Big Data) that are generated in routine clinical practice. AI has the potential to make a significant impact on healthcare by improving the efficiency of clinical care, providing personalized treatment, and identifying new disease biomarkers. Machine learning (ML) and deep learning (DL) are AI techniques that utilize large datasets and computational power for analysis and decision making. There are three main ML techniques: supervised learning, unsupervised learning, and reinforcement learning. Another functional AI service that has been presented is natural language processing (NLP), and it is applicable for analyzing patient documentation. In this paper, the scope of AI workflow, the most often used algorithms, and their performance metrics are explained. Explainable artificial intelligence (XAI) has a prominent potential to be a useful tool for clinicians as it provides full transparency into an AI model’s decision-making process, but few applications have been reviewed. In this paper, the challenges and limitations of AI in cardiology are discussed in terms of ethical, methodological, and legal issues. Furthermore, the successful establishment of good practices toward the right development and deployment of automated ML-based systems will ensure a regulatory framework that can strengthen patients’ trust in AI/ML-based clinical decision support systems.
{"title":"Artificial Intelligence as an Emerging Tool for Cardiologists","authors":"Łukasz Ledziński, G. Grześk","doi":"10.3390/ecb2023-14339","DOIUrl":"https://doi.org/10.3390/ecb2023-14339","url":null,"abstract":": In the world of data, there is an urgent need to find ways to extract knowledge and information for improving patient care. Artificial intelligence (AI) is an emerging tool that has the potential to provide cardiologists with new insights and knowledge. The healthcare industry has already begun the digital transformation of vast reams of data (Big Data) that are generated in routine clinical practice. AI has the potential to make a significant impact on healthcare by improving the efficiency of clinical care, providing personalized treatment, and identifying new disease biomarkers. Machine learning (ML) and deep learning (DL) are AI techniques that utilize large datasets and computational power for analysis and decision making. There are three main ML techniques: supervised learning, unsupervised learning, and reinforcement learning. Another functional AI service that has been presented is natural language processing (NLP), and it is applicable for analyzing patient documentation. In this paper, the scope of AI workflow, the most often used algorithms, and their performance metrics are explained. Explainable artificial intelligence (XAI) has a prominent potential to be a useful tool for clinicians as it provides full transparency into an AI model’s decision-making process, but few applications have been reviewed. In this paper, the challenges and limitations of AI in cardiology are discussed in terms of ethical, methodological, and legal issues. Furthermore, the successful establishment of good practices toward the right development and deployment of automated ML-based systems will ensure a regulatory framework that can strengthen patients’ trust in AI/ML-based clinical decision support systems.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116013778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Childhood (pediatric) obesity is becoming increasingly common at an alarming rate. Obese children are more likely to develop insulin resistance, relative insulin insufficiency, and type 2 diabetes. Recent research suggests that mitochondrial dysfunction is related to, and may be predictive of, insulin resistance among adult relatives of type 2 diabetes patients. Mitochondria produce ATP, which is used to create energy, especially in muscle tissue, and they play a role in glucose and fat metabolism. Mitochondrial dysfunction plays a role in the development of metabolic diseases. Affected tissues include adipose, liver, and skeletal muscle, which all contribute to food metabolism. Since cells require a balance between mitochondrial ATP generation through oxidative phosphorylation (OXPHOS) and proton gradient dissipation to avoid damage caused by reactive oxygen species (ROS), abnormal mitochondrial function leads to fat buildup and insulin resistance. Obesity, insulin resistance, and type 2 diabetes (T2D) are all caused by growth and transcription factors that influence mitochondrial gene expression. On the other hand, obesity and hypertension both impair heart mitochondrial biogenesis and function. By promoting the expression of chaperones, SIRT1, and antioxidants, moderate weight reduction reduces systemic inflammation and improves mitochondrial dysfunction. In this review, the variables that relate mitochondrial dysfunction to pediatric obesity are discussed.
{"title":"Inter-Relationships of Pediatric Obesity and Mitochondrial Dysfunction","authors":"R. Saad, H. Qutob","doi":"10.3390/ecb2023-14336","DOIUrl":"https://doi.org/10.3390/ecb2023-14336","url":null,"abstract":": Childhood (pediatric) obesity is becoming increasingly common at an alarming rate. Obese children are more likely to develop insulin resistance, relative insulin insufficiency, and type 2 diabetes. Recent research suggests that mitochondrial dysfunction is related to, and may be predictive of, insulin resistance among adult relatives of type 2 diabetes patients. Mitochondria produce ATP, which is used to create energy, especially in muscle tissue, and they play a role in glucose and fat metabolism. Mitochondrial dysfunction plays a role in the development of metabolic diseases. Affected tissues include adipose, liver, and skeletal muscle, which all contribute to food metabolism. Since cells require a balance between mitochondrial ATP generation through oxidative phosphorylation (OXPHOS) and proton gradient dissipation to avoid damage caused by reactive oxygen species (ROS), abnormal mitochondrial function leads to fat buildup and insulin resistance. Obesity, insulin resistance, and type 2 diabetes (T2D) are all caused by growth and transcription factors that influence mitochondrial gene expression. On the other hand, obesity and hypertension both impair heart mitochondrial biogenesis and function. By promoting the expression of chaperones, SIRT1, and antioxidants, moderate weight reduction reduces systemic inflammation and improves mitochondrial dysfunction. In this review, the variables that relate mitochondrial dysfunction to pediatric obesity are discussed.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133507222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. U. Khan, Momin Khan, Q. Ullah, M. Z. Khan, A. Sohail, Rehmat Islam, H. Bilal, S. Ullah, A. Iqbal
{"title":"In Vitro and In Vivo Effects of Conventional and Chitosan Nanoparticle-Encapsulated Miltefosine Drug for Treatment of Cutaneous Leishmaniasis","authors":"R. U. Khan, Momin Khan, Q. Ullah, M. Z. Khan, A. Sohail, Rehmat Islam, H. Bilal, S. Ullah, A. Iqbal","doi":"10.3390/ecb2023-14334","DOIUrl":"https://doi.org/10.3390/ecb2023-14334","url":null,"abstract":"","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127257270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Diabetes mellitus (DM) is a widespread, long-term illness recognised as elevated blood sugar. Infection, inadequate blood flow, neuropathy and insufficient proliferative and cytokine signalling slow down wound healing in diabetics. Recent research has shown that the majority of wound treatments that are currently on the market are not sufficient to meet patients’ needs. Advancements in nanotechnology can help researchers to establish new therapeutic methods or improve existing ones. Nanodrug delivery systems, in particular, have emerged as a major player in the area of dermal restoration due to their slow drug release and abilities to tether bioactive components to the targeted area and dramatically improve the effectiveness of medication. Manufactured agents in the field of nanotherapy, such as nanoparticles and nanoscafolds, have recently shown promise for use in the management of diabetic wounds. Nanoparticles used in medicine have a large surface area relative to their size. Because of this, they have a better chance of interacting with living things and entering wounds. They work effectively in the slow, localised delivery of drugs that stimulate cell-to-cell communication, proliferation, blood vessel formation, signalling, and biomolecule production during wound healing. One or more therapeutic molecules can be released into the intended site slowly over time using nanoparticles. The promising results seen with nanoparticulate systems indicate that research into this technology’s capabilities will expand in the near future, expanding nanotechnology’s substantial medical benefits. Focusing on diabetic wounds, we evaluated the viability and efficacy of the most recently developed nanotechnology-based medications. In this article, we scrutinise the unmet needs of the wound-healing field, as well as the future directions of the currently available technologies, while also discussing novel approaches that can advance the field.
{"title":"Burgeoning Nanotechnology for Diabetic Wound Healing: A Novel Approach to the Future","authors":"Debojyoti Mandal, J. Gupta","doi":"10.3390/ecb2023-14291","DOIUrl":"https://doi.org/10.3390/ecb2023-14291","url":null,"abstract":": Diabetes mellitus (DM) is a widespread, long-term illness recognised as elevated blood sugar. Infection, inadequate blood flow, neuropathy and insufficient proliferative and cytokine signalling slow down wound healing in diabetics. Recent research has shown that the majority of wound treatments that are currently on the market are not sufficient to meet patients’ needs. Advancements in nanotechnology can help researchers to establish new therapeutic methods or improve existing ones. Nanodrug delivery systems, in particular, have emerged as a major player in the area of dermal restoration due to their slow drug release and abilities to tether bioactive components to the targeted area and dramatically improve the effectiveness of medication. Manufactured agents in the field of nanotherapy, such as nanoparticles and nanoscafolds, have recently shown promise for use in the management of diabetic wounds. Nanoparticles used in medicine have a large surface area relative to their size. Because of this, they have a better chance of interacting with living things and entering wounds. They work effectively in the slow, localised delivery of drugs that stimulate cell-to-cell communication, proliferation, blood vessel formation, signalling, and biomolecule production during wound healing. One or more therapeutic molecules can be released into the intended site slowly over time using nanoparticles. The promising results seen with nanoparticulate systems indicate that research into this technology’s capabilities will expand in the near future, expanding nanotechnology’s substantial medical benefits. Focusing on diabetic wounds, we evaluated the viability and efficacy of the most recently developed nanotechnology-based medications. In this article, we scrutinise the unmet needs of the wound-healing field, as well as the future directions of the currently available technologies, while also discussing novel approaches that can advance the field.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114105242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Skurikhin, M. Zhukova, N. Ermakova, L. Kogai, A. Dygai
The survival and cytotoxicity of reprogrammed human CD8+ T-cells (hrT-cells) were evaluated in a culture of cancer stem cells (CSCs) isolated from a patient with small-cell lung cancer (SCLC). T-cells were isolated from the blood of healthy volunteers and patients with lung diseases. Reprogramming with MEK and PD-1 inhibitors increased the survival and cytotoxicity of allogeneic T-cells in vitro. The positive effect of reprogramming is more pronounced in patients with lung diseases than in healthy donors. Autologous hrT-cells showed high effectiveness in eliminating CSCs. Thus, in vitro studies are significant in the selection of potential cell donors and evaluating the effectiveness of their reprogramming.
{"title":"In Vitro Studies May Be Useful in Donor Selection and Evaluating the Effectiveness of CD8+ T-Cell Reprogramming: Experience of a Pilot Study","authors":"E. Skurikhin, M. Zhukova, N. Ermakova, L. Kogai, A. Dygai","doi":"10.3390/ecb2023-14289","DOIUrl":"https://doi.org/10.3390/ecb2023-14289","url":null,"abstract":"The survival and cytotoxicity of reprogrammed human CD8+ T-cells (hrT-cells) were evaluated in a culture of cancer stem cells (CSCs) isolated from a patient with small-cell lung cancer (SCLC). T-cells were isolated from the blood of healthy volunteers and patients with lung diseases. Reprogramming with MEK and PD-1 inhibitors increased the survival and cytotoxicity of allogeneic T-cells in vitro. The positive effect of reprogramming is more pronounced in patients with lung diseases than in healthy donors. Autologous hrT-cells showed high effectiveness in eliminating CSCs. Thus, in vitro studies are significant in the selection of potential cell donors and evaluating the effectiveness of their reprogramming.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126086605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic Tool for Non-Small Cell Lung Cancer (NSCLC) Lyophilized Serum","authors":"M. S. Mohammed, A. Mohammed","doi":"10.3390/ecb2023-14293","DOIUrl":"https://doi.org/10.3390/ecb2023-14293","url":null,"abstract":"","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125582024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ostróżka-Cieślik, M. Przybyła, Weronika Wójcik, Klaudia Birówka, Marta Majczyna, B. Dolińska
: Insulin affects wound healing by reducing inflammation, regulating oxidative reactions, and increasing collagen deposition. Despite the many benefits of insulin, there is still no topical product for insulin delivery through the skin on the market. The aim of this study was to review the literature on the development of a hydrogel formulation of insulin to promote wound healing. An analysis of papers published between 2000 and 2022 was carried out. Embase, Medline, PubMed, and Cochrane Library databases were used. Hydrogels may provide a starting point for developing new products or improving the efficacy of designed epidermal forms of insulin. The hydrogels used allow efficient delivery of the peptide into the wound environment.
{"title":"Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing","authors":"A. Ostróżka-Cieślik, M. Przybyła, Weronika Wójcik, Klaudia Birówka, Marta Majczyna, B. Dolińska","doi":"10.3390/ecb2023-14290","DOIUrl":"https://doi.org/10.3390/ecb2023-14290","url":null,"abstract":": Insulin affects wound healing by reducing inflammation, regulating oxidative reactions, and increasing collagen deposition. Despite the many benefits of insulin, there is still no topical product for insulin delivery through the skin on the market. The aim of this study was to review the literature on the development of a hydrogel formulation of insulin to promote wound healing. An analysis of papers published between 2000 and 2022 was carried out. Embase, Medline, PubMed, and Cochrane Library databases were used. Hydrogels may provide a starting point for developing new products or improving the efficacy of designed epidermal forms of insulin. The hydrogels used allow efficient delivery of the peptide into the wound environment.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123913299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giada Magni, F. Tatini, M. Rossi, G. de Siena, R. Cicchi, F. Pavone, S. Bacci, F. Rossi
: The following study investigated the effects of blue LED light (410–430 nm) on wound healing in mice with superficial and full-thickness skin wounds. The wounds were treated with blue LED light (20.6 J/cm 2 , 30 s), and biopsies were collected over 6 days. Results showed modulation of cytokine release, increased number of granulocytes and mast cells, increased density of vessels with mast cells expressing platelet-derived growth factor, and improved collagen deposition compared to untreated wounds. The study concluded that blue light leads to faster and more effective wound healing and improved skin morphology.
{"title":"In Vivo Evidence of Blue LED Light Photobiomodulation","authors":"Giada Magni, F. Tatini, M. Rossi, G. de Siena, R. Cicchi, F. Pavone, S. Bacci, F. Rossi","doi":"10.3390/ecb2023-14287","DOIUrl":"https://doi.org/10.3390/ecb2023-14287","url":null,"abstract":": The following study investigated the effects of blue LED light (410–430 nm) on wound healing in mice with superficial and full-thickness skin wounds. The wounds were treated with blue LED light (20.6 J/cm 2 , 30 s), and biopsies were collected over 6 days. Results showed modulation of cytokine release, increased number of granulocytes and mast cells, increased density of vessels with mast cells expressing platelet-derived growth factor, and improved collagen deposition compared to untreated wounds. The study concluded that blue light leads to faster and more effective wound healing and improved skin morphology.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125347081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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