Tiago Azevedo, A. Faustino-Rocha, L. Barros, T. Finimundy, Manuela Matos, Paula A. Oliveira
: Santolina chamaecyparissus , commonly known as cotton lavender, is a plant with recognized medicinal properties that has been traditionally used for several conditions, including providing relief in premenstrual syndrome and the treatment of infections and digestive disorders. Its extracts have been found to have a range of therapeutic effects and can be used in modern medicine due to their analgesic, anticancer, anti-inflammatory, antimicrobial, antioxidant and antispasmodic properties, or as central nervous system depressants. This work provides the readers with a review of the current research on Santolina chamaecyparissus , emphasizing its potential as a novel therapeutic approach in modern medicine, making it a functional food and nutraceutical.
{"title":"Santolina chamaecyparissus L.: A Brief Overview of Its Medicinal Properties","authors":"Tiago Azevedo, A. Faustino-Rocha, L. Barros, T. Finimundy, Manuela Matos, Paula A. Oliveira","doi":"10.3390/ecb2023-14281","DOIUrl":"https://doi.org/10.3390/ecb2023-14281","url":null,"abstract":": Santolina chamaecyparissus , commonly known as cotton lavender, is a plant with recognized medicinal properties that has been traditionally used for several conditions, including providing relief in premenstrual syndrome and the treatment of infections and digestive disorders. Its extracts have been found to have a range of therapeutic effects and can be used in modern medicine due to their analgesic, anticancer, anti-inflammatory, antimicrobial, antioxidant and antispasmodic properties, or as central nervous system depressants. This work provides the readers with a review of the current research on Santolina chamaecyparissus , emphasizing its potential as a novel therapeutic approach in modern medicine, making it a functional food and nutraceutical.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125294160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Jullien, E. R. Graziosi, Michel Gauthier, M. Drouet, S. Francois, D. Riccobono
: Acute localized irradiation accidents may evolve into a musculocutaneous radiation-induced syndrome that leaves a significant underlying muscle defect despite standard treatment. The identification of new therapeutic targets is therefore necessary to improve post-irradiation muscle repair. Thus, the validation of an in vivo model of radiation-induced muscle injury has been initiated in C57Bl/6J mice. In the model presented in this study, the high dose ionizing radiation exposure is focused on gastrocnemius and soleus muscles and does not affect bones and a part of hind limb vascularization. It aims at identifying original metabolic pathways specifically involved in muscle damage and evaluating innovative therapeutic strategies.
{"title":"A New Murine Highly Localized High-Dose Muscle Radiation Model as a Tool to Develop Innovative Countermeasures to Treat Radio-Induced Muscular Lesions","authors":"N. Jullien, E. R. Graziosi, Michel Gauthier, M. Drouet, S. Francois, D. Riccobono","doi":"10.3390/ecb2023-14280","DOIUrl":"https://doi.org/10.3390/ecb2023-14280","url":null,"abstract":": Acute localized irradiation accidents may evolve into a musculocutaneous radiation-induced syndrome that leaves a significant underlying muscle defect despite standard treatment. The identification of new therapeutic targets is therefore necessary to improve post-irradiation muscle repair. Thus, the validation of an in vivo model of radiation-induced muscle injury has been initiated in C57Bl/6J mice. In the model presented in this study, the high dose ionizing radiation exposure is focused on gastrocnemius and soleus muscles and does not affect bones and a part of hind limb vascularization. It aims at identifying original metabolic pathways specifically involved in muscle damage and evaluating innovative therapeutic strategies.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114883797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giada Magni, F. Cherchi, M. Banchelli, F. Tatini, P. Nardini, D. Guasti, E. Coppi, A. Pugliese, M. Fraccalvieri, S. Bacci, F. Rossi
: Fibroblasts play a crucial role in wound healing and skin fibrosis. It is also probably the cell model used to study in vitro photobiomodulation. Our previous in vivo results evidenced a faster recovery in blue-light-treated wounds (410–430 nm). In vitro experiments demonstrated that the lower dose increases cell metabolism, while higher doses (30.9 and 41.2 J/cm 2 ) reduce it. Furthermore, 20.6 J/cm 2 affects outward currents and Cytochrome C. Here, we described our preliminary results on the effects of blue LED light on mitochondria and reactive oxygen species production. Globally, our results demonstrated that short-wavelength blue LED light has PBM properties.
{"title":"Effects of Short-Wavelength Blue Light on Fibroblasts, Experimental Evidence in Wound Healing and Cutaneous Fibrosis","authors":"Giada Magni, F. Cherchi, M. Banchelli, F. Tatini, P. Nardini, D. Guasti, E. Coppi, A. Pugliese, M. Fraccalvieri, S. Bacci, F. Rossi","doi":"10.3390/ecb2023-14268","DOIUrl":"https://doi.org/10.3390/ecb2023-14268","url":null,"abstract":": Fibroblasts play a crucial role in wound healing and skin fibrosis. It is also probably the cell model used to study in vitro photobiomodulation. Our previous in vivo results evidenced a faster recovery in blue-light-treated wounds (410–430 nm). In vitro experiments demonstrated that the lower dose increases cell metabolism, while higher doses (30.9 and 41.2 J/cm 2 ) reduce it. Furthermore, 20.6 J/cm 2 affects outward currents and Cytochrome C. Here, we described our preliminary results on the effects of blue LED light on mitochondria and reactive oxygen species production. Globally, our results demonstrated that short-wavelength blue LED light has PBM properties.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127105239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Varsha Unni, P. Abishad, Pokkittath Radhakrishnan Arya, Bibin Mohan, S. Juliet, Lijo John, P. Nambiar, V. K. Vinod, A. Karthikeyan, N. Kurkure, S. Barbuddhe, D. Rawool, J. Vergis
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{"title":"Eco-Friendly One Pot Synthesis of Zinc Oxide Nanoparticles Using Catkin Extract of Piper longum: In Vitro Antibacterial, Antioxidant and Antibiofilm Potential against Multi Drug Resistant Enteroaggregative E. coli ","authors":"Varsha Unni, P. Abishad, Pokkittath Radhakrishnan Arya, Bibin Mohan, S. Juliet, Lijo John, P. Nambiar, V. K. Vinod, A. Karthikeyan, N. Kurkure, S. Barbuddhe, D. Rawool, J. Vergis","doi":"10.3390/ecb2023-14269","DOIUrl":"https://doi.org/10.3390/ecb2023-14269","url":null,"abstract":".","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123699048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Inflammatory bowel disease is a term used for chronic inflammatory condition that includes two diseases, i
炎症性肠病是一种慢性炎症性疾病，包括两种疾病
{"title":"In Silico Approach to Assessing the Polyphenols from Krishna Tulsi (Ocimum tenuiflorum L.) as a Keap1/Nrf2 Receptor for the Treatment of Inflammatory Bowel Disease","authors":"Satish Kumar, B. Sarkar","doi":"10.3390/ecb2023-14207","DOIUrl":"https://doi.org/10.3390/ecb2023-14207","url":null,"abstract":": Inflammatory bowel disease is a term used for chronic inflammatory condition that includes two diseases, i","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116942848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Skurikhin, O. Pershina, M. Zhukova, A. Pakhomova, N. Ermakova, D. Widera, E. Pan, L. Sandrikina, L. Kogai, Nikolai Kushlinskii, Sergey Morozov, A. Kubatiev, A. Dygai
{"title":"Reprogrammed CD8+ T-Cells Isolated from the Mouse Spleen Increase the Number of Immune Cells with Antitumor Activity and Decrease the Amount of Cancer Stem Cells","authors":"E. Skurikhin, O. Pershina, M. Zhukova, A. Pakhomova, N. Ermakova, D. Widera, E. Pan, L. Sandrikina, L. Kogai, Nikolai Kushlinskii, Sergey Morozov, A. Kubatiev, A. Dygai","doi":"10.3390/ecb2023-14132","DOIUrl":"https://doi.org/10.3390/ecb2023-14132","url":null,"abstract":"","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122501695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Lung cancer is one of the deadliest cancers, responsible for more than 1.80 million deaths annually worldwide, and it is on the priority list of the WHO. In the current scenario, when cancer cells become resistant to drugs, making them less effective and leaving the patient in vulnerable conditions. To overcome this situation, researchers are constantly working on new drugs and medications that can help fight drug resistance and improve patients’ outcomes. In this study, we have taken five main proteins of lung cancer, namely RSK4 N-terminal kinase, guanylate kinase, cyclin-dependent kinase 2, kinase CK2 holoenzyme, and tumour necrosis factor-alpha, and screened the prepared Drug Bank library with 155,888 compounds against all using three Glide-based docking algorithms, namely HTVS, standard precision and extra precise, with a docking score ranging from − 5.422 to − 8.432 Kcal/mol. The poses were filtered with the MM GBSA calculations, which helped to identify Imidazolidinyl urea C11H16N8O8 (DB14075) as a multitargeted inhibitor for lung cancer, validated with advanced computations such as ADMET and interaction pattern fingerprints. Further, it is proposed to optimise the compound with Jaguar and MD Simulation for at least 100 ns with NPT ensemble class to analyse the deviation and fluctuations and possible interactions for stability and experimental validation on the A549 cell line.
{"title":"Multialgorithm-Based Docking Reveals Imidazolidinyl Urea as a Multitargeted Inhibitor for Lung Cancer","authors":"Shaban Ahmad, K. Raza","doi":"10.3390/ecb2023-14138","DOIUrl":"https://doi.org/10.3390/ecb2023-14138","url":null,"abstract":": Lung cancer is one of the deadliest cancers, responsible for more than 1.80 million deaths annually worldwide, and it is on the priority list of the WHO. In the current scenario, when cancer cells become resistant to drugs, making them less effective and leaving the patient in vulnerable conditions. To overcome this situation, researchers are constantly working on new drugs and medications that can help fight drug resistance and improve patients’ outcomes. In this study, we have taken five main proteins of lung cancer, namely RSK4 N-terminal kinase, guanylate kinase, cyclin-dependent kinase 2, kinase CK2 holoenzyme, and tumour necrosis factor-alpha, and screened the prepared Drug Bank library with 155,888 compounds against all using three Glide-based docking algorithms, namely HTVS, standard precision and extra precise, with a docking score ranging from − 5.422 to − 8.432 Kcal/mol. The poses were filtered with the MM GBSA calculations, which helped to identify Imidazolidinyl urea C11H16N8O8 (DB14075) as a multitargeted inhibitor for lung cancer, validated with advanced computations such as ADMET and interaction pattern fingerprints. Further, it is proposed to optimise the compound with Jaguar and MD Simulation for at least 100 ns with NPT ensemble class to analyse the deviation and fluctuations and possible interactions for stability and experimental validation on the A549 cell line.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133438451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scheme 8-Isoprostane and Interleukin-8 Levels in Patients with Primary Biliary Cholangitis","authors":"A. Bauer, A. Habior","doi":"10.3390/ecb2023-14139","DOIUrl":"https://doi.org/10.3390/ecb2023-14139","url":null,"abstract":"","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129556537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesca Bruno, V. Sturiale, Desiree Brancato, Laura Gil, I. Olazabal, F. Pinedo, Ana B Rebolledo, S. Saccone, Concetta Federico
{"title":"Nuclear Tau as an Early Molecular Marker of Alzheimer’s Disease","authors":"Francesca Bruno, V. Sturiale, Desiree Brancato, Laura Gil, I. Olazabal, F. Pinedo, Ana B Rebolledo, S. Saccone, Concetta Federico","doi":"10.3390/ecb2023-14131","DOIUrl":"https://doi.org/10.3390/ecb2023-14131","url":null,"abstract":"","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127586352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Khalaf, Yuanyuan Wei, Samiah Yasmin Abdul Kadir, J. Zainol, Zahraa Oglah
Integral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, resulting in this superfamily’s tremendous physiological functional diversity. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer. Moreover, the development of effective treatment methods for pancreatic cancer has been hindered by the lack of understanding of the pathogenesis, partly due to the difficulty in studying human tissue samples. However, scientific research on this topic has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions.
{"title":"TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target","authors":"A. Khalaf, Yuanyuan Wei, Samiah Yasmin Abdul Kadir, J. Zainol, Zahraa Oglah","doi":"10.3390/ecb2023-14133","DOIUrl":"https://doi.org/10.3390/ecb2023-14133","url":null,"abstract":"Integral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, resulting in this superfamily’s tremendous physiological functional diversity. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer. Moreover, the development of effective treatment methods for pancreatic cancer has been hindered by the lack of understanding of the pathogenesis, partly due to the difficulty in studying human tissue samples. However, scientific research on this topic has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions.","PeriodicalId":265361,"journal":{"name":"The 2nd International Electronic Conference on Biomedicines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117143531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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