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Informing Policy from Prices: An Overview of California Nursing Homes 从价格向政策提供信息:加州养老院概述
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36806
Karen El Hajj
Introduction: The rising cost of healthcare along with the aging demographic requires the attention of policy makers. The United States’ nursing home industry is costly to older adults, requiring many to resort to government funded Medicare to offset these costs. This study aims to understand determinants of nursing home prices in the state of California. Variables included in the analysis are selected based on previous literature on the costs of nursing homes in the US. Methods: The data were analyzed using a multi-variable regression analysis. The analysis sample included 1,121 nursing homes across California, using facility level and governmental data that is publically available for the years of 2016-2017. Data collected included financial indicators (net income), ownership (for-profit, non-profit) represented as a dummy variable, occupancy rates, reimbursement rates (Medicare & Medicaid), staffing, quality and competition variables such as nursing homes per county. Results: The regression analysis indicated that ownership type (for-profit), competition and occupancy rates have a negative significant effect on nursing home prices. Whereas, reimbursement rates of both Medicare and Medicaid, home income and staffing levels have a positive significant effect, driving further nursing home prices. Conclusion: The study aimed to understand the relevant variables that influence nursing home prices in the state of Califronia. The regression analysis yielded significant results for various factors including reimbursement rates, occupancy rates and the number of nursing homes per county. However, a notable limitation to the study is the inability to generalize these factors to the rest of the US due to state specific health policies. Determinants such as reimbursement rates and nursing homes per county vary by governmental decisions, therefore, a comprehensive policy tool could be designed to alter nursing home costs through state health policies.
引言:随着人口老龄化,医疗保健成本的上升需要政策制定者的关注。美国的养老院行业对老年人来说是昂贵的,要求许多人求助于政府资助的医疗保险来抵消这些成本。本研究旨在了解加州养老院价格的决定因素。分析中包含的变量是根据以前关于美国养老院成本的文献选择的。方法:采用多变量回归分析。分析样本包括加利福尼亚州的1121家养老院,使用了2016-2017年公开提供的设施级别和政府数据。收集到的数据包括财务指标(净收入)、所有权(营利和非营利)(以虚拟变量表示)、入住率、报销率(医疗保险和医疗补助)、人员配备、质量和竞争变量(如每个县的养老院)。结果:回归分析表明,所有权类型(营利性)、竞争和入住率对养老院价格有显著的负向影响。然而,医疗保险和医疗补助的报销率、家庭收入和人员配备水平对养老院价格有显著的正向影响。结论:本研究旨在了解影响加州养老院价格的相关变量。回归分析结果表明,各因素包括报销率、入住率和每个县的养老院数量。然而,该研究的一个显著局限性是,由于各州具体的卫生政策,无法将这些因素推广到美国其他地区。每个县的报销率和养老院等决定因素因政府的决定而异,因此,可以设计一种综合政策工具,通过国家卫生政策来改变养老院的成本。
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引用次数: 0
A spatio-temporal modelling of Covid-19 infections in Toronto’s neighbourhoods 多伦多社区Covid-19感染的时空模型
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36812
S. H. Fu
Introduction & Objective: Besides age and sex as established risk factors of COVID-19 infection, social factor is found to be a determinant, with people of lower socioeconomic status suffer disproportionately from the disease. The city of Toronto has one of the highest COVID-19 infection rates in Canada. This analysis aims to explore the socioeconomic correlates associated with COVID-19 infection and the temporal trends among different age groups in Toronto using geospatial modeling. Methods: A Bayesian spatio-temporal analysis was conducted using public COVID-19 cases data for Toronto. The case data were modeled using the Besag-York-Mollie (BYM) model, implemented in R-INLA. The model adjusted for age, sex, neighbourhood-level socioeconomic factors, crime rates, and population density. Random effects were included to account for neighbourhood-level variation and for spatial autocorrelation. Temporal trends of COVID-19 cases were modelled using second-order random walks to allow non-parametric estimations. Results: The model estimates showed that men are at higher risk of COVID-19 infection. Among neighbourhood factors, higher home prices, education level, and population density are at lower risks, while belonging to an improvement area showed elevated risks. The temporal trends differed by age, with ages 20-59 showed increased risks over time, compared to the youngest and older age groups. Model predictions showed that northwest Toronto has higher risk compared to the rest of Toronto. Conclusion: The higher COVID-19 infection risks in the Northwest will require increase public health effort to control disease spread in this area. The ecological correlates identified in this analysis will also help to guide the ongoing vaccination plans.
引言与目的:除了年龄和性别是COVID-19感染的既定危险因素外,社会因素也是一个决定因素,社会经济地位较低的人患该病的比例更高。多伦多市是加拿大COVID-19感染率最高的城市之一。本分析旨在利用地理空间模型探讨与COVID-19感染相关的社会经济相关性以及多伦多不同年龄组的时间趋势。方法:利用多伦多公开的COVID-19病例数据进行贝叶斯时空分析。病例数据采用在R-INLA中实现的Besag-York-Mollie (BYM)模型建模。该模型根据年龄、性别、社区社会经济因素、犯罪率和人口密度进行了调整。随机效应被包括在内,以解释邻近水平的变化和空间自相关性。使用二阶随机漫步对COVID-19病例的时间趋势进行建模,以允许非参数估计。结果:模型估计显示,男性感染COVID-19的风险更高。在邻里因素中,较高的房价、教育水平和人口密度的风险较低,而属于改善区域的风险较高。时间趋势因年龄而异,与最年轻和年龄较大的人群相比,20-59岁的人群随着时间的推移风险增加。模型预测显示,与多伦多其他地区相比,多伦多西北部的风险更高。结论:西北地区新型冠状病毒感染风险较高,需要加大公共卫生工作力度,控制疫情传播。在这一分析中确定的生态相关因素也将有助于指导正在进行的疫苗接种计划。
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引用次数: 0
The Use of Email and Secure Messaging between Residents and Patients at St. Michael’s Family Medicine Residency Program 在圣迈克尔家庭医学住院医师项目中,住院医师和患者之间使用电子邮件和安全信息
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36994
Saba Javaid, M. Derocher
Background: The use of email and secure messaging between physicians and patients is increasing in frequency. P PHowever, residents lack formal training in e-communication, patient privacy and other confidentiality issues associated with it. There is also a paucity of assessment tools and faculty feedback regarding this practice.Objective: The objective is to investigate use of email and secure messaging between patients and residents at St. Michael’s family medicine residency program and analyze educational constructs, facilitators, and barriers relevant to this practice.Methods: Three cross-sectional surveys were conducted at St. Michael’s family medicine residency program in 2018-2020. Each resident in postgraduate year 1 & 2 received an email inviting them to respond. Results: The prevalence of residents using email or secure messaging is increasing (47% in 2018 vs 81% in 2020). Over 86% of FM residents used hospital/clinic computers in 2020 but the proportion of residents using personal computers rose to 60% that year. A prominent barrier appears to be the ‘potential for inappropriate use by patients’, which was cited as ‘fairly’ or ‘very’ important at rates of 85.3%, 86.9%, and 73.68% in 2018, 2019 and 2020, respectively. 76.4% and 56.52% of residents cited lack of consistent advice/guidelines as a barrier in the years 2018 and 2019, respectively. The perception of support has risen (33.3% residents reporting supervisors as ‘very’ or ‘somewhat’ supportive versus 57.8% in 2020). The majority reported ‘rarely’ or ‘never’ getting feedback/guidance from their supervisors.Conclusions: Our study found an increase in the use of email and secure messaging. Residents are increasingly using their personal computers which likely reflects the increase in virtual models of care. Residents have concerns regarding the appropriate use of such messaging by patients. Lack of supervision may pose a risk of patient confidentiality/privacy breach. There is a need for curricular re-design and faculty development around this practice.
背景:医生和病人之间使用电子邮件和安全信息的频率正在增加。然而,住院医生在电子通信、患者隐私和其他与之相关的保密问题上缺乏正式的培训。关于这种做法的评估工具和教师反馈也很缺乏。目的:目的是调查圣迈克尔家庭医学住院医师项目中患者和住院医师之间使用电子邮件和安全信息的情况,并分析与此实践相关的教育结构、促进因素和障碍。方法:对2018-2020年圣迈克尔家庭医学住院医师项目进行三次横断面调查。研究生一年级和二年级的每位学生都收到了一封邀请他们回复的电子邮件。结果:居民使用电子邮件或安全信息的普及率正在上升(2018年为47%,2020年为81%)。2020年,超过86%的FM居民使用医院/诊所电脑,但当年使用个人电脑的居民比例上升至60%。一个突出的障碍似乎是“患者使用不当的可能性”,在2018年、2019年和2020年,被认为“相当”或“非常”重要的比例分别为85.3%、86.9%和73.68%。2018年和2019年,分别有76.4%和56.52%的居民认为缺乏一致的建议/指南是障碍。对支持的看法有所上升(33.3%的居民表示主管“非常”或“有些”支持,而2020年这一比例为57.8%)。大多数人表示“很少”或“从未”从他们的主管那里得到反馈/指导。结论:我们的研究发现,电子邮件和安全信息的使用有所增加。居民越来越多地使用他们的个人电脑,这可能反映了虚拟护理模式的增加。住院医生对病人适当使用这种信息表示担忧。缺乏监督可能会造成患者保密/隐私泄露的风险。围绕这一实践,有必要重新设计课程和发展教师队伍。
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引用次数: 1
The Canadian Community’s Knowledge on the History and Matters of Indigenous Peoples of Canada 加拿大社区关于加拿大土著人民历史和问题的知识
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36894
Ronaz Remtulla, A. Mohamed, Jason Liu, A. Thayaparan, Areez Remtulla, Cora Clearwater, Mim Harder, Jeya Thayaparan
Objective: To gather informal evidence on the Canadian community’s knowledge of the history and matters of Indigenous Peoples of Canada and identify gaps in education and awareness. Methods: A cross-sectional study was performed through a structured and anonymous questionnaire that was completed on a voluntary basis. Knowledge gained from partnering with Indigenous members of the community and participating in a blanket exercise was used to produce questions surrounding current and historical matters of Indigenous peoples of Canada. The blanket exercise is an Indigenous-led educational program that tells the story of Canadian history from an Indigenous lens. The inclusion criteria for the study was individuals enrolled in a primary and/or secondary Canadian educational institution and non-Indigenous self-identification. The survey sample most closely represents individuals between 18 to 24 years old in the population. Results: The target demographic scored an average of 54.4% on knowledge-based survey questions. Most individuals answered questions more accurately on topics relating to historical facts, such as the content of the Indian Act, than they did on topics relating to current Indigenous issues, like percent of land mass occupied by Indigenous peoples. Despite indicating primary and secondary schooling as the main source of education on Indigenous history, 86% of participants found their education “limited” and “inadequate”. Results of the survey do not definitively represent the Canadian population, as this was an informal study completed on a voluntary basis. Conclusion: Survey results highlighted gaps in the Canadian population’s knowledge on challenges faced by Indigenous members of Canada. Many respondents recognized an inadequate primary and/or secondary education on Indigenous issues, suggesting a need for educational reform. Increasing awareness on Indigenous matters can potentially reduce discrimination and systemic racism, which can improve social determinants of health. This data can serve as an informal basis of knowledge until further research is conducted.
目的:收集关于加拿大社区对加拿大土著人民历史和问题的知识的非正式证据,并确定教育和认识方面的差距。方法:横断面研究是通过一个结构化的匿名问卷,在自愿的基础上完成。从与社区土著成员合作和参加一揽子演习中获得的知识被用来提出有关加拿大土著人民当前和历史问题的问题。这是一项由原住民主导的教育计划,从原住民的角度讲述加拿大的历史故事。该研究的纳入标准是在加拿大小学和/或中学教育机构注册的个人和非土著自我认同。调查样本最能代表人口中18至24岁的个体。结果:目标人群在知识调查问题上的平均得分为54.4%。大多数人回答与历史事实有关的问题,如《印第安人法案》的内容,比他们回答与当前土著问题有关的问题,如土著人民占据的土地面积的百分比更准确。尽管表明中小学教育是土著历史教育的主要来源,但86%的参与者认为他们的教育“有限”和“不足”。调查的结果并不一定代表加拿大人口,因为这是一项在自愿基础上完成的非正式研究。结论:调查结果突出表明,加拿大人口对加拿大土著成员所面临的挑战的认识存在差距。许多答复者承认关于土著问题的小学和(或)中学教育不足,这表明需要进行教育改革。提高对土著问题的认识有可能减少歧视和系统性种族主义,从而改善健康的社会决定因素。在进行进一步的研究之前,这些数据可以作为非正式的知识基础。
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引用次数: 0
Constructing Long Short-Term Memory Networks to Predict Ulcerative Colitis Progression from Longitudinal Gut Microbiome Profiles 构建长短期记忆网络预测溃疡性结肠炎进展从纵向肠道微生物组谱
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36763
Xu Li, P. Hu
Introduction & Objective: Ulcerative colitis is an intestinal disorder with an erratic progression in which the patients suffer from capricious remissions and changeful severities. Lacking prognosis to the UC progression can lead to irrational treatments that adversely affect the patients’ quality of life. Existing studies have stated a connection between gut microbiomes and UC progression. We aim to construct Long Short-Term Memory (LSTM) networks to predict UC progression (remission & severity) from longitudinal gut microbiome data. Methods: Using one-step and two-step modelling strategies, we develop a standard LSTM network, an encoder-decoder LSTM network, a convolutional LSTM network, and several benchmarking classifiers such as random forests. For high-dimensional data, we also implement auto-encoder to select variables in addition to baseline procedures like principal component analysis. We train each model using a longitudinal microbiome data, and validate them via a 10-round set splitting approach. Results: Each proposed model shows the potential to predict UC progression, but they do not reach an optimal level for medical utilizations. The encoder-decoder LSTM demonstrates superiority over the other classifiers while the auto-encoder outperformed the baseline variable selectors. Conclusion: We support the capacity of Long Short-Term Memory (LSTM) networks to predict UC progression from longitudinal microbiome data, and verify the strength of autoencoder networks in selecting features from high dimensional data.
简介与目的:溃疡性结肠炎是一种进展不稳定的肠道疾病,患者病情的缓解和严重程度变化无常。缺乏对UC进展的预后可导致不合理的治疗,从而对患者的生活质量产生不利影响。现有研究表明肠道微生物群与UC进展之间存在联系。我们的目标是构建长短期记忆(LSTM)网络来预测UC的进展(缓解和严重程度),从纵向肠道微生物数据。方法:使用一步和两步建模策略,我们开发了一个标准LSTM网络,一个编码器-解码器LSTM网络,一个卷积LSTM网络和几个基准分类器,如随机森林。对于高维数据,除了主成分分析等基线程序外,我们还实现了自动编码器来选择变量。我们使用纵向微生物组数据训练每个模型,并通过10轮集分割方法验证它们。结果:每个提出的模型都显示出预测UC进展的潜力,但它们没有达到医疗利用的最佳水平。编码器-解码器LSTM优于其他分类器,而自编码器优于基线变量选择器。结论:我们支持长短期记忆(LSTM)网络从纵向微生物组数据中预测UC进展的能力,并验证了自编码器网络从高维数据中选择特征的能力。
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引用次数: 1
Exploring the intersection of traumatic brain injury and mental health in survivors of intimate partner violence 探索创伤性脑损伤和亲密伴侣暴力幸存者心理健康的交集
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.37002
D. Toccalino, Amy Moore, Sophia Chuon Gutierrez, A. Colantonio, Christine M. Wickens, H. Haag
Introduction: One in four Canadian women experience intimate partner violence (IPV) in their lifetime. The COVID-19 pandemic has significantly increased rates of IPV globally and the level of violence encountered, exposing IPV survivors to greater risk of physical injury, including traumatic brain injury (TBI). Up to 75% of survivors are suspected of sustaining a TBI and 50-75% experience mental health or substance use challenges (MHSU) as a result of IPV, resulting in extensive personal, social, and economic implications. Objective: The objective of this scoping review was to synthesize what is currently known in the literature about MHSU and TBI among survivors of IPV and identify gaps. Methods: MEDLINE, EMBASE, PsycINFO, CINAHL, Cochrane, Scopus, and Web of Science were searched for relevant articles using a search strategy including text words and subject headings related to TBI, IPV, and MHSU. Two reviewers independently assessed articles for inclusion. Results: The search identified 399 unique articles, 34 of which were included in this study. Of these, 11 articles reported on MHSU in IPV-related TBI and 9 articles reported on both TBI and MHSU in IPV but did not discuss the groups together. The remainder were reviews or theses that noted MHSU in IPV-related TBI. Included articles predominantly focused on cis-gendered women in heterosexual relationships and were conducted in the United States. Only three articles focused on the experiences of Black or Indigenous women and none of the included studies discussed implications of co-occurring TBI and MHSU on survivor’s healthcare-related needs or access to care. Conclusions: Despite the high rates of co-occurring TBI and MHSU among survivors of IPV, there is little research on this intersection and no investigation of the impacts on the health system. Future research should focus on identifying the healthcare-related needs of survivors and identifying and mitigating barriers to access.
四分之一的加拿大妇女在其一生中经历过亲密伴侣暴力(IPV)。2019冠状病毒病大流行大大增加了全球IPV发病率和暴力程度,使IPV幸存者面临更大的身体伤害风险,包括创伤性脑损伤(TBI)。多达75%的幸存者被怀疑患有创伤性脑损伤,50-75%的幸存者因IPV经历精神健康或物质使用挑战(MHSU),造成广泛的个人、社会和经济影响。目的:本综述的目的是综合目前已知的关于IPV幸存者中MHSU和TBI的文献,并确定差距。方法:使用包含TBI、IPV和MHSU相关文本词和主题标题的搜索策略,对MEDLINE、EMBASE、PsycINFO、CINAHL、Cochrane、Scopus和Web of Science等相关文章进行检索。两名审稿人独立评估文章是否纳入。结果:检索到399篇独特的文章,其中34篇被纳入本研究。其中,11篇文章报道了ipvv相关TBI中的MHSU, 9篇文章同时报道了ipvv中的TBI和MHSU,但没有一起讨论这两组。其余的是在ipvv相关的TBI中注意到MHSU的综述或论文。纳入的文章主要集中在异性恋关系中的顺性女性,并在美国进行。只有三篇文章关注黑人或土著妇女的经历,而且纳入的研究中没有一篇讨论同时发生的创伤性脑损伤和MHSU对幸存者医疗保健相关需求或获得医疗保健的影响。结论:尽管IPV幸存者中同时发生TBI和MHSU的比例很高,但关于这一交叉点的研究很少,也没有对卫生系统影响的调查。未来的研究应侧重于确定幸存者的卫生保健相关需求,并确定和减轻获得卫生保健的障碍。
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引用次数: 0
Predictors of Greater Vaping Dependence and Higher Vaping Frequencies among Canadian Youth and Young Adults over 12-Month 在12个月以上的加拿大青年和年轻人中,更大的电子烟依赖和更高的电子烟频率的预测因素
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36997
Tianru Wang, Safa Ahmad, R. Schwartz, M. Chaiton, S. Bondy
Background: The prevalence of electronic cigarette use has doubled among Canadian youth and young adults in recent years. However, little is known about the predictors of greater vaping nicotine dependence. This study identifies variables associated with greater Penn-State Electronic Cigarette Dependence Index (PS-ECDI) scores and higher vaping sessions per month (SPM) among this population. Methods: Data were drawn from a longitudinal study that recruited 1048 Canadian participants aged 16-26 in 2018. Quota sampling was used to ensure enough regular e-cigarette users were recruited. The current study restricted analyses to the 459 participants who were baseline vapers and have completed both the baseline and 12-month follow-up surveys. Linear regression analyses were employed, with the use of the best subset modelling strategy to obtain reduced models. Results: Baseline vapers who were ≥ 18 and married or cohabiting, had used other tobacco products, had 30 or more puffs per vaping session, started vaping at an earlier age, vaped to quit/reduce smoking, and had used a disposable cigarette-like vaping device and/or an advanced box or tubular device and/or a pod vape in the last 6-month were associated with greater PS-ECDI scores compared to their respective counterparts. Additionally, baseline vapers who were ≥18 and married or cohabiting, had used cannabis, had 30 or more puffs per vaping session; vaped to reduce/quit smoking and/or because friends vape; had used a pod vape in the last 6-month were more likely to have higher SPM at the 12-month follow-up compared to their respective counterparts. Conclusion: 11% of the participants were classified as high vaping nicotine dependence and 42% of the participants had increased their SPM over 1 year. The findings provide targets for vaping reduce or cessation programs and potential policy change in the regulation and sales of pod vape.
背景:近年来,加拿大青少年和年轻人中电子烟的使用率翻了一番。然而,人们对电子烟尼古丁依赖程度的预测因素知之甚少。这项研究确定了与宾州电子烟依赖指数(PS-ECDI)得分较高和每月吸电子烟次数(SPM)较高相关的变量。方法:数据来自一项纵向研究,该研究于2018年招募了1048名年龄在16-26岁之间的加拿大参与者。配额抽样是为了确保招募到足够多的普通电子烟用户。目前的研究仅限于459名参与者,他们是基线吸烟者,并完成了基线和12个月的随访调查。采用线性回归分析,利用最佳子集建模策略获得约简模型。结果:年龄≥18岁、已婚或同居、使用过其他烟草产品、每次吸30次或更多、较早开始吸电子烟、通过电子烟戒烟/减少吸烟、在过去6个月内使用过一次性香烟状电子烟装置和/或先进的盒式或管状电子烟装置和/或豆荚电子烟的基线电子烟吸烟者,与各自的同行相比,PS-ECDI得分更高。此外,年龄≥18岁、已婚或同居、使用过大麻、每次吸30支或更多的基线吸烟者;抽电子烟是为了减少/戒烟和/或因为朋友抽电子烟;在过去的6个月里使用过电子烟的人,在12个月的随访中,与他们各自的同行相比,更有可能有更高的SPM。结论:11%的参与者被归类为高度尼古丁依赖,42%的参与者在一年内增加了他们的SPM。这些发现为减少或戒烟计划以及监管和销售电子烟的潜在政策变化提供了目标。
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引用次数: 0
Employing Media Messaging Strategies to Respond to COVID-19 Misinformation 利用媒体消息策略应对COVID-19错误信息
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.37001
R. Field, Gul-e-Naghma Saeed, Mariana Villada Rivera, S. Campanella, Lauren S Tailor
Introduction: The COVID-19 pandemic has revealed critical gaps in the public’s knowledge of infectious diseases. Experts, including the World Health Organization, acknowledge that an “infodemic” of misinformation is spreading at the same time as the pandemic. Furthermore, 13% of Canadians age 50 and younger reported using social media as their primary source of information about COVID-19. Thus, in January 2020, the Infectious Disease Working Group (IDWG) was formed by a group of students at the Dalla Lana School of Public Health, University of Toronto. The IDWG’s Media Messaging Team (MMT) uses Knowledge Translation (KT) strategies to increase access to evidence-based information related to public health and COVID-19. Specifically, MMT uses virtual platforms, including Twitter and Instagram (@infectious_info), to disseminate information to a wide audience. Objectives: The MMT aims to produce content to dispel pervasive and harmful myths about COVID-19, raise public awareness, and advocate for health equity. Methods: The team creates 2-4 pieces of original content per week on topics such as Ontario Government legislation updates, myth-busting series, and “Wednesday Series” (summaries of novel research findings). The IDWG employs an equity lens to ensure that the content takes into account the experiences and needs of diverse groups, and that graphics are representative of a diverse audience. Health communication strategies are used to promote audience engagement through compelling and bold content design. Results: The Instagram account has over 4,400 followers, with some posts surpassing 50,000 views. Qualitative feedback from social media followers indicates that this project is addressing an emerging gap in knowledge resulting from unclear messaging from official bodies, the spread of mis/disinformation, and disparities in health literacy levels. Conclusions: The findings can inform the development and implementation of KT strategies to reach a wide audience and increase the uptake of public health information.
导言:2019冠状病毒病大流行暴露了公众对传染病知识的严重空白。包括世界卫生组织(World Health Organization)在内的专家承认,在疫情蔓延的同时,一场错误信息的“信息大流行”正在蔓延。此外,13%的50岁及以下的加拿大人报告使用社交媒体作为他们关于COVID-19的主要信息来源。因此,2020年1月,传染病工作组(IDWG)由多伦多大学达拉拉纳公共卫生学院的一群学生组成。IDWG的媒体消息小组(MMT)使用知识翻译(KT)战略来增加获得与公共卫生和COVID-19相关的循证信息的机会。具体来说,MMT使用虚拟平台,包括Twitter和Instagram(@传染性ous_info),向广泛的受众传播信息。目标:MMT旨在制作内容,消除关于COVID-19的普遍和有害的神话,提高公众意识,倡导卫生公平。方法:团队每周创建2-4篇原创内容,主题包括安大略省政府立法更新,神话打破系列和“周三系列”(新颖研究成果摘要)。IDWG采用公平视角来确保内容考虑到不同群体的经验和需求,并且图像能够代表不同的受众。健康传播策略通过引人注目和大胆的内容设计来促进受众的参与。结果:这个Instagram账号有超过4400名粉丝,一些帖子的浏览量超过了5万。来自社交媒体关注者的定性反馈表明,该项目正在解决由于官方机构的信息不明确、错误信息/虚假信息的传播以及卫生知识普及水平的差异而导致的新出现的知识差距。结论:研究结果可以为KT战略的制定和实施提供信息,以达到广泛的受众并增加对公共卫生信息的吸收。
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引用次数: 0
Toward Health Equity Guide Interview Project: 迈向健康公平指南访谈项目:
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36748
Rachel Fields
For my practicum, I worked with the Health Equity Integration Team (HEIT) to improve the application of Sex- and Gender-Based Analysis + (SGBA+) at The Public Health Agency of Canada (PHAC). SGBA+ is an analytical tool used in the federal government to ensure the consideration of diversity and intersectionality in programs and policies. One of the training resources on SGBA+ at PHAC is called Toward Health Equity: The SGBA+ Guide. This guide provides an overview of SGBA+, associated concepts, and a case study. I was part of a team tasked with updating this document to make the guide more applicable to current agency priorities. However, in revising the guide it became clear that there was a significant gap in understanding what document users needed. To make this guide as user-friendly and relevant as possible, I suggested that we conduct interviews with key informants throughout the agency to gather feedback and identify barriers to SGBA+ application. This project was part of a Knowledge Translation (KT) process that involved employees from many different roles and divisions at PHAC. The interviews allowed readers to identify the guide’s strengths, weaknesses, and gaps in clarity and content. Improving SGBA+ application at the federal public health level is important, because it is the agency’s way of applying a health equity lens to the work that they do. This project was also significant because it interrupted the standard process of KT, which follows a linear path and only integrates user feedback at the end. Instead, this project promoted an iterative process, involving document users throughout the development and revision of the guide to create a final product that is more tailored to their needs. Clear and effective communication is crucial to public health practice; this project is an example of how to achieve that by incorporating constructive feedback.
在我的实习中,我与健康公平整合团队(HEIT)合作,在加拿大公共卫生署(PHAC)改进性别和基于性别的分析+ (SGBA+)的应用。SGBA+是联邦政府使用的一种分析工具,以确保在计划和政策中考虑到多样性和交叉性。PHAC的SGBA+培训资源之一是“迈向健康公平:SGBA+指南”。本指南概述了SGBA+、相关概念和案例研究。我是一个小组的成员,负责更新该文件,使该指南更适用于当前机构的优先事项。然而,在修订指南时,很明显,在了解文件用户需要什么方面存在重大差距。为了使本指南尽可能方便用户并具有相关性,我建议我们与整个机构的关键线人进行面谈,以收集反馈并确定SGBA+应用的障碍。该项目是知识翻译(KT)过程的一部分,涉及PHAC许多不同角色和部门的员工。通过访谈,读者可以确定指南的优点、缺点以及清晰度和内容上的差距。改善SGBA+在联邦公共卫生层面的应用非常重要,因为这是该机构在其工作中应用卫生公平视角的方式。这个项目也很重要,因为它打断了KT的标准流程,该流程遵循线性路径,最后只集成用户反馈。相反,这个项目促进了一个迭代过程,在整个指南的开发和修订过程中涉及文档用户,以创建更适合他们需要的最终产品。明确和有效的沟通对公共卫生实践至关重要;这个项目是如何通过整合建设性反馈来实现这一目标的一个例子。
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引用次数: 0
Statistical Modelling of Population-Level Exonic Variant Frequency Data with an Emphasis on Rare Variants 种群水平外显子变异频率数据的统计建模,重点是罕见变异
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36809
Yining Shi, S. Bull
Introduction & Objective: Rare variants with allele frequency smaller than 1% are postulated to be associated with disease susceptibility. Since allele frequencies vary globally, the use of population control data that does not match the study population can produce bias. The research question is to identify factors that explain variation in allele frequency across populations. The secondary question is to evaluate the potential bias in using population as control data when studying variants. We use data from gnomAD (Genome Aggregation Database) to answer these questions. Methods: We apply each of three model formulations: Linear, Logistic, and Poisson to explain how the frequency or count of variants depends on population subgroup/ancestry, functional annotation, sex, and disease status. We also evaluate interactions between population subgroups and functional annotation. Results: For very rare variants (allele frequency < 0.1%), likelihood ratio testing (LRT) provides evidence that allele frequencies vary with functional annotation and population in all three model formulations. By LRT, interactions of population and functional annotation are significant in the Logistic model and the Poisson model. The goodness-of-fit statistics show a better fit in the linear model compared to low frequency variants. Conclusion: We observe that population & functional annotation affect variant frequencies, and conclude that detection of differences across populations and annotations is model scale-dependent, especially for different degrees of rareness. Therefore, statisticians need to carefully consider the potential for bias when using gnomAD as control data. Moreover, gnomAD is a great resource for studies dealing with rare variants.
引言与目的:等位基因频率小于1%的罕见变异被认为与疾病易感性相关。由于等位基因频率在全球范围内存在差异,因此使用与研究人群不匹配的人口控制数据可能会产生偏差。研究的问题是找出解释人群中等位基因频率变化的因素。第二个问题是评估在研究变异时使用群体作为控制数据的潜在偏差。我们使用来自gnomAD (Genome Aggregation Database)的数据来回答这些问题。方法:我们应用三种模型公式中的每一种:线性、Logistic和泊松来解释变异的频率或计数如何取决于种群亚群/祖先、功能注释、性别和疾病状态。我们还评估了人口子群和功能注释之间的相互作用。结果:对于非常罕见的变异(等位基因频率< 0.1%),似然比检验(LRT)提供了证据,证明等位基因频率在所有三种模型公式中随功能注释和群体而变化。通过LRT,在Logistic模型和泊松模型中,种群和功能注释的相互作用是显著的。拟合优度统计表明,与低频变量相比,线性模型的拟合效果更好。结论:我们观察到种群和功能注释影响变异频率,并得出结论,种群和注释之间的差异检测依赖于模型尺度,特别是对于不同程度的稀缺性。因此,统计学家在使用gnomAD作为对照数据时需要仔细考虑潜在的偏差。此外,gnomAD是研究罕见变异的重要资源。
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引用次数: 0
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University of Toronto Journal of Public Health
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