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Improving end-of-life conversations in the post-MAiD era 在后maid时代改善临终对话
Pub Date : 2021-09-15 DOI: 10.33137/utjph.v2i2.36749
K. Serota, A. Ho
Legalizing medical assistance in dying (MAiD) has transformed how palliative and hospice care providers (PHCPs) engage in end of life conversations with patients and their loved ones. We do not currently know how PHCPs in the Toronto area have experienced this tremendous shift, and what challenges they have faced in transforming their practice to accommodate MAiD conversations. We must understand the unique challenges faced by PHCPs so that we can improve the education, resources, and supports available to these essential healthcare providers. We also must ensure that Canadians receive the highest quality care at the end of life, whether or not they choose to pursue a medically assisted death. To examine these unique challenges, I interviewed 22 PHCPs to document their experiences of engaging in end-of-life conversations in the post-MAiD era. Participants included physicians, nurses, social workers, and other allied health professionals employed in faith-based and secular institutions. Their personal beliefs about MAiD varied widely; some identified as conscientious objectors, while others actively engaged in MAiD assessment and provision. Initial thematic analysis revealed that challenges include translating the federal legislation into medical practice; navigating inefficient institutional policies and role ambiguity; developing conversation techniques to share MAiD information with patients and families in a balanced way that is informative yet uncoercive; and, navigating the ethical and organizational issues that arise when patients with declining capacity pursue MAiD. Finally, PHCPs shared personal experiences of burnout, emotional weight, and stigma. Understanding how these factors impact the work and lives of PHCPs allows us to develop targeted strategies to improve the institutional policies surrounding MAiD conversations, referrals, and procedures, as well as decrease the negative personal and emotional consequences of engaging in end-of-life conversations in the post-MAiD era.
临终医疗援助(MAiD)的合法化改变了姑息治疗和临终关怀提供者(phcp)与患者及其亲人进行临终对话的方式。我们目前还不知道多伦多地区的phcp是如何经历这种巨大的转变的,以及他们在转变实践以适应MAiD会话时面临的挑战。我们必须了解初级保健提供者面临的独特挑战,以便我们能够改善这些基本保健提供者的教育、资源和支持。我们还必须确保加拿大人在生命结束时得到最高质量的护理,无论他们是否选择医疗辅助死亡。为了研究这些独特的挑战,我采访了22位初级医师,记录了他们在后maid时代参与临终对话的经历。参与者包括医生、护士、社会工作者和其他受雇于宗教机构和世俗机构的专职卫生专业人员。他们对MAiD的个人看法差异很大;一些人被认定为出于良心拒服兵役者,而另一些人则积极参与评估和提供MAiD。初步专题分析显示,挑战包括将联邦立法转化为医疗实践;应对低效的制度政策和角色模糊;发展对话技巧,以平衡的方式与患者和家属分享MAiD信息,既提供信息,又不强制;并且,在能力下降的患者寻求MAiD时出现的道德和组织问题。最后,初级保健医师分享了个人倦怠、情绪负担和耻辱的经历。了解这些因素如何影响初级保健医生的工作和生活,使我们能够制定有针对性的策略,以改善围绕MAiD谈话、转诊和程序的制度政策,并减少在后MAiD时代参与临终谈话的负面个人和情感后果。
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引用次数: 0
Combat Food Insecurity amid the COVID-19 Pandemic 在2019冠状病毒病大流行期间抗击粮食不安全
Pub Date : 2021-09-15 DOI: 10.33137/utjph.v2i2.36839
Yiran Wang
Food insecurity has long been a public health issue in Northwestern Ontario, which adds a substantial burden on social costs and health care. Food insecurity is further exacerbated during the COVID-19 pandemic, due to the closure or limited hours of emergency food and transportation services. Low-income seniors (age>65 years old) face additional risks of food insecurity due to their vulnerability to the coronavirus. To help reduce food insecurity in this specific population, an emergency food program named “Senior Food Bags” was established by Roots to Harvest at the City of Thunder Bay, which provides insights on incorporating skill-building into food distribution activities.     As a dietetic intern, I participated in the planning and implementation of the project. Considering that a lack of fresh produce, limited cooking skills, and comorbidities are major barriers for local low-income seniors, we aim to impart seniors with basic cooking skills and create recipes to consider health concerns. Hence, a weekly recipe was developed to encourage seniors to use healthy ingredients (e.g. fresh and preserved produces of proteins, grains, fruits, and vegetables) included in the bag for meal preparation. No ID was required, and seniors were respectfully approached for communication during the distribution. The mid-term survey suggested that all senior participants (n=40) thought the project helped reduce food insecurity during COVID-19. 1/3 of participants mentioned being more confident and capable of preparing healthier meals.  The project illustrated that skill-building and dignified services in emergency food programs can do more than provide food. To enhance the capacity of food security, the first step is to equip individuals with intentions and skills to combat food challenges. Therefore, in addition to food distribution, food donor projects should also focus on fostering individuals’ food literacy development to empower them and aid public health.
长期以来,食品不安全一直是安大略省西北部的一个公共卫生问题,这给社会成本和医疗保健增加了沉重的负担。在2019冠状病毒病大流行期间,由于紧急粮食和运输服务关闭或时间有限,粮食不安全状况进一步加剧。低收入老年人(65岁至65岁)因易受冠状病毒感染而面临粮食不安全的额外风险。为了帮助减少这一特定人群的粮食不安全状况,“根到收获”组织在桑德贝市建立了一个名为“老年人食品袋”的紧急食品项目,该项目提供了将技能培养纳入食品分发活动的见解。作为一名营养学实习生,我参与了项目的策划和实施。考虑到缺乏新鲜农产品、烹饪技能有限以及合并症是当地低收入老年人的主要障碍,我们的目标是向老年人传授基本的烹饪技能,并创建考虑健康问题的食谱。因此,制定了每周食谱,鼓励老年人使用包内的健康食材(例如新鲜和腌制的蛋白质、谷物、水果和蔬菜)准备膳食。分发过程中,不需要身份证,并有礼貌地走近老年人进行沟通。中期调查显示,所有高级参与者(40人)都认为该项目有助于减少COVID-19期间的粮食不安全状况。三分之一的参与者提到他们更自信,更有能力准备更健康的食物。该项目表明,紧急粮食方案中的技能培养和有尊严的服务可以做的不仅仅是提供粮食。要提高粮食安全能力,第一步是使个人具备应对粮食挑战的意愿和技能。因此,除了粮食分配外,粮食捐助项目还应侧重于培养个人的粮食素养发展,以增强他们的权能并帮助公共卫生。
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引用次数: 0
Performance of statistical methods to address treatment non-adherence in pragmatic clinical trials with point-treatment settings: a simulation study 在点治疗设置的实用临床试验中处理治疗不依从的统计方法的表现:一项模拟研究
Pub Date : 2021-09-15 DOI: 10.33137/utjph.v2i2.36762
M. B. Hossain, L. Mosquera, Mohammad Karim
Introduction: The instrumental variable (IV)-based methods (e.g., two-stage least square [2SLS], two-stage residual inclusion [2SRI], and nonparametric causal bound [NPCB]) can be used to address non-adherence in pragmatic trials. These methods require assumptions, e.g., exclusion restriction, although they are known to handle unmeasured confounding. The inverse probability-weighted per-protocol [IPW-PP] method is useful in the same setting but requires different assumptions (no unmeasured confounding). Although all these methods aim to address the same problem, comprehensive simulations to compare their performance are absent in the literature. We performed extensive simulations when (1) confounding is present, (2) confounder is unmeasured but exclusion restriction is met, (3) exclusion restriction is violated, and (4) non-adherence is one-sided and differential. Method: We compared the performance in terms of bias, standard error (SE), mean squared error (MSE), and 95% confidence interval coverage probability. Results: For setting-1, IPW-PP outperforms IV-methods in terms of bias, SE, MSE, and coverage for <80% non-adherence but produces high bias beyond that point. IPW-PP also has high biases, but 2SLS and 2SRI work well for setting-2. For setting-3, 2SLS and 2SRI perform the worst in all scenarios; IPW-PP produces unbiased estimates when necessary confounders are measured and adjusted. For setting-4, IPW-PP has less bias, but 2SLS and 2SRI have higher SE and MSE. NPCB has wider bounds in all scenarios. We also analyze a two-arm trial to estimate the effect of vitamin A supplementation on childhood mortality after addressing non-adherence. Conclusion: We need to be cautious using the IPW-PP when non-adherence is very high or strong unmeasured confounding and should avoid using the IV methods when the exclusion restriction assumption is violated or high differential non-adherence. Since assumptions are different and often untestable for IPW-PP and IV methods, we suggest analyzing data using both methods for a robust conclusion.
基于工具变量(IV)的方法(例如,两阶段最小二乘法[2SLS],两阶段残差纳入[2SRI]和非参数因果界[NPCB])可用于解决实用试验中的不依从性。这些方法需要假设,例如排除限制,尽管已知它们可以处理无法测量的混杂。逆概率加权协议[IPW-PP]方法在相同的设置中是有用的,但需要不同的假设(没有未测量的混淆)。尽管所有这些方法都旨在解决相同的问题,但文献中缺乏比较其性能的综合模拟。我们在以下情况下进行了广泛的模拟:(1)存在混杂因素,(2)混杂因素未测量但满足排除限制,(3)违反排除限制,以及(4)非依从性是单侧和差异的。方法:我们从偏倚、标准误差(SE)、均方误差(MSE)和95%置信区间覆盖概率方面比较了性能。结果:对于设置-1,IPW-PP在偏倚、SE、MSE和<80%非依从性覆盖率方面优于iv -方法,但超过该点会产生高偏倚。IPW-PP也有很高的偏差,但2SLS和2SRI在set -2中工作得很好。对于set -3, 2SLS和2SRI在所有场景中表现最差;当测量和调整必要的混杂因素时,IPW-PP产生无偏估计。对于set -4, IPW-PP的偏倚较小,而2SLS和2SRI的SE和MSE较高。NPCB在所有情况下都有更宽的边界。我们还分析了一项两组试验,以估计在解决不依从性后补充维生素a对儿童死亡率的影响。结论:IPW-PP在非依从性非常高或未测量混杂因素较强时应谨慎使用,在违反排除限制假设或高差异非依从性时应避免使用IV方法。由于IPW-PP和IV方法的假设是不同的,而且往往是不可检验的,我们建议使用这两种方法来分析数据,以获得一个可靠的结论。
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引用次数: 0
Nurses Perceptions of the Utilization of the Violence Assessment Tool (VAT) in Northeastern Ontario 安大略省东北部护士对暴力评估工具(VAT)使用的看法
Pub Date : 2021-09-13 DOI: 10.33137/utjph.v2i2.37004
Oghenefego (Fego) Akpomi-Eferakeya, J. Horrigan, R. Heale, E. Donato
Workplace violence (WPV) is an ongoing problem in health care. Most of the cases of WPV are caused by the patients, patients’ families, and friends. Violence in hospitals among registered nurses has led to 56% of lost time injuries, and in 2018, Ontario’s Workplace Safety and Insurance Board (WSIB) reported 13% of lost time injuries due to WPV. The Public Services Health and Safety Association (PSHSA) created the Violence Assessment Tool [VAT] to predict the possible risk of violence from patients in acute care settings. Health care workers can use the VAT to assess risk, apply possible control measures and improve their safety. As part of a larger study, the aim of this research is to explore nurses’ perceptions of the utilization of the VAT in assessing the potential risk of violence, and to identify any gaps, challenges, or improvements needed in the VAT. An Interpretive Description research design by Sally Thorne in (2016) will be used. The model that will guide this study is the Haddon Matrix framework of workplace violence prevention. The study will involve three focus groups via zoom virtual meetings with 6 to 8 participants per session, and an expected total of 18-24 participants. Focus group interviews will use semi-structured questions to guide the discussion among nurses working in a Northeastern Ontario hospital. Interpretive description data analysis will be guided by Thorne’s processes of data analysis. This will be the first study to examine nurses’ perceptions of the VAT in Ontario. The findings of this study will help to determine the predictive validity of the VAT and any potential changes that may be needed. The findings of this study could lead to reduced violence and associated costs within the healthcare sector.
工作场所暴力是卫生保健领域一个持续存在的问题。大多数病例是由患者、患者家属和朋友引起的。注册护士在医院的暴力行为导致56%的误工伤害,2018年,安大略省工作场所安全和保险委员会(WSIB)报告称,13%的误工伤害是由暴力造成的。公共服务健康和安全协会(PSHSA)创建了暴力评估工具(VAT),以预测急症护理机构中患者可能的暴力风险。卫生保健工作者可以使用增值税来评估风险,采取可能的控制措施并提高其安全性。作为一项更大规模研究的一部分,本研究的目的是探讨护士在评估潜在暴力风险时对增值税使用情况的看法,并确定增值税中存在的差距、挑战或需要改进的地方。将使用Sally Thorne在(2016)中设计的解释性描述研究。指导本研究的模型是工作场所暴力预防的Haddon矩阵框架。该研究将涉及三个焦点小组,通过缩放虚拟会议,每次会议有6至8名参与者,预计总共有18-24名参与者。焦点小组访谈将使用半结构化问题来指导安大略省东北部医院护士之间的讨论。解释性描述数据分析将以索恩的数据分析过程为指导。这将是第一项研究,以检查护士的增值税在安大略省的看法。本研究的结果将有助于确定增值税的预测有效性和任何可能需要的潜在变化。这项研究的结果可能导致减少医疗保健部门内的暴力和相关费用。
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引用次数: 0
High dimensional Selection with Interactions for Binary Outcome (HDSI-BO) Algorithm in Classifying Height Indicators Through Social-life and Well-being Factors 基于社会生活和幸福因素对身高指标进行分类的高维选择二元结果交互(HDSI-BO)算法
Pub Date : 2021-09-13 DOI: 10.33137/utjph.v2i2.36764
Ziqian Zhuang, Wei Xu, Rahi Jain
Introduction: High dimensional Selection with Interactions for Binary Outcome (HDSI-BO) algorithm can incorporate interaction terms and combine with existing techniques for feature selection. Simulation studies have validated the ability of HDSI-BO to select true features and consequently, improve prediction accuracy compared to standard algorithms. Our goal is to assess the applicability of HDSI-BO in combining different techniques and measure its predictive performance in a real data study of predicting height indicators by social-life and well-being factors. Methods: HDSI-BO was combined with logistic regression, ridge regression, LASSO, adaptive LASSO, and elastic net. Two-way interaction terms were considered. Hyperparameters used in HDSI-BO were optimized through genetic algorithms with five-fold cross-validation. To measure the performance of feature selection, we fitted final models by logistic regression based on the sets of selected features and used the model’s AUC as a measure. 30 trials were repeated to generate a range of the number of selected features and a 95% confidence interval for AUC. Results: When combined with all of the above methods, HDSI-BO methods achieved higher final AUC values both in terms of mean and confidence interval. In addition, HDSI-BO methods effectively narrowed down the sets of selected features and interaction terms compared with standard methods. Conclusion: The HDSI-BO algorithm combines well with multiple standard methods and has comparable or better predictive performance compared with the standard methods. The computational and time complexity of HDSI-BO is higher but still acceptable. Considering AUC as the single metric cannot comprehensively measure the feature selection performance. More effective metrics of performance should be explored for future work.
介绍:HDSI-BO (High dimensional Selection with Interactions for Binary Outcome)算法可以将交互项与现有的特征选择技术相结合。仿真研究已经验证了HDSI-BO选择真实特征的能力,因此,与标准算法相比,提高了预测精度。我们的目标是评估HDSI-BO在结合不同技术时的适用性,并在通过社会生活和幸福因素预测身高指标的实际数据研究中测量其预测性能。方法:采用logistic回归、脊回归、LASSO、自适应LASSO、弹性网等方法对HDSI-BO进行综合评价。考虑了双向相互作用条件。通过遗传算法优化HDSI-BO中使用的超参数,并进行五次交叉验证。为了衡量特征选择的性能,我们基于选择的特征集通过逻辑回归拟合最终模型,并使用模型的AUC作为度量。重复进行30次试验,以产生所选特征的数量范围和AUC的95%置信区间。结果:HDSI-BO方法与上述所有方法联合使用时,在平均值和置信区间上均获得更高的最终AUC值。此外,与标准方法相比,HDSI-BO方法有效地缩小了所选特征和交互项的集合。结论:HDSI-BO算法与多种标准方法结合良好,预测性能与标准方法相当或更好。HDSI-BO的计算复杂度和时间复杂度较高,但仍然可以接受。将AUC作为单一指标不能全面衡量特征选择性能。应该为今后的工作探索更有效的绩效指标。
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引用次数: 0
The World Health Organization’s approach to equity 世界卫生组织对公平的态度
Pub Date : 2021-09-13 DOI: 10.33137/utjph.v2i2.36895
M. Amri
The World Health Organization (WHO), as the most prominent global health institution as a specialized agency of the United Nations, has expressed concern for health equity as part of its mandate, “the attainment by all peoples of the highest possible level of health”. However, there is a lack of clarity around the WHO’s fundamental definition and conceptualization of equity. Through drawing on the WHO’s Urban Health Equity Assessment and Response Tool (Urban HEART) as an illustrative case, the aim is to determine how the WHO operationalizes equity in practice. Preliminary findings suggest there is no consistent understanding of what the goal of Urban HEART is. This research has direct implications for practice: not only can the findings be applied to other global health work that seeks to improve equity, but the WHO is planning to reinstate Urban HEART. As such, this research may be beneficial in guiding these plans. Further, the findings yield an important consideration for global and public health policy and practice more broadly: the need to clarify objectives around equity (e.g. because how equity is defined determines the work undertaken and the populations served).
世界卫生组织(世卫组织)作为联合国的一个专门机构,是全球最著名的卫生机构,它对保健公平问题表示关切,认为这是其任务的一部分,即"使所有人民都能达到尽可能高的健康水平"。然而,世卫组织对公平的基本定义和概念并不明确。通过将世卫组织的城市卫生公平评估和应对工具(Urban HEART)作为一个说明性案例,目的是确定世卫组织如何在实践中实现公平。初步研究结果表明,对城市心脏计划的目标没有一致的理解。这项研究对实践具有直接意义:研究结果不仅可以应用于寻求改善公平的其他全球卫生工作,而且世界卫生组织正在计划恢复Urban HEART。因此,这项研究可能有助于指导这些计划。此外,调查结果对全球和公共卫生政策以及更广泛的做法提出了重要考虑:需要澄清围绕公平的目标(例如,因为如何界定公平决定了所开展的工作和所服务的人群)。
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引用次数: 0
Resuming In-person Psychological Treatment in the Era of COVID-19 新冠肺炎时代恢复面对面心理治疗
Pub Date : 2021-09-13 DOI: 10.33137/utjph.v2i2.36996
Gul-e-Naghma Saeed, Sabrin Hossain, N. Schoueri-Mychasiw, Daisy Radha Singla
Background: Patient-centered research has emerged as a promising model to adequately address the needs and preferences of patient populations with mental disorders. The Scaling Up Maternal Mental healthcare by Increasing access to Treatment (SUMMIT) Trial aims to increase access to psychological treatment and implements a multi-stakeholder perspective to understand the needs/preferences of perinatal populations with symptoms of depression and anxiety. Specifically, this pragmatic, non-inferiority randomized effectiveness trial examines whether Behavioral Activation (BA) delivered via telemedicine is as effective as in-person treatment. However, due to COVID-19, the study suspended in-person BA sessions and completely shifted to telemedicine. To ensure BA remains widely accessible, the SUMMIT team strives to resume in-person treatment in the near future. Objective: To gain perspectives of key stakeholders on the potential barriers and facilitators for SUMMIT participants to resume in-person BA sessions in a COVID-19 context.   Methods: A focus group discussion (1 hour) was conducted via Zoom with N=9 stakeholders, including patient advocates, nurses, clinicians, and researchers. Qualitative data was coded using NVivo and content analysis was performed to quantify frequently endorsed themes. Results: The majority of stakeholders considered resuming in-person BA sessions to be a challenge amidst COVID-19, with more barriers than facilitators mentioned overall. Most commonly endorsed barriers that participants may face when attending in-person treatment included arranging childcare (n=8; 89%) and discomfort/fear of coming to the hospital (n=6; 67%). The most widely endorsed facilitators for resuming in-person treatment during COVID-19 were clearly communicating hospital and transportation safety precautions to participants (n=7; 78%) and conducting in-person sessions at an off-site location (n=6; 67%). Conclusion: This study identified critical facilitators of resuming in-person BA sessions that can inform: (1) how to resume in-person BA sessions and (2) the development and implementation of strategies to make BA more patient-centered for perinatal populations during COVID-19. Objective: To gain perspectives of key stakeholders on the potential barriers and facilitators for SUMMIT participants to resume in-person BA sessions in a COVID-19 context.    Methods: A focus group discussion (1 hour) was conducted via Zoom with N=9 stakeholders, including patient advocates, nurses, clinicians, and researchers. Qualitative data was coded using NVivo and a content analysis was performed to quantify frequently endorsed themes. Results: The majority of stakeholders considered resuming in-person BA sessions to be a challenge amidst COVID-19, with more barriers than facilitators mentioned overall. Most commonly endorsed barriers that participants may face when attending in-person treatment included arranging childcare (n=8; 89%) and discomfort/fear of comin
背景:以患者为中心的研究已经成为一种有希望的模式,以充分解决精神障碍患者群体的需求和偏好。通过增加获得治疗的机会来扩大孕产妇精神保健(SUMMIT)试验旨在增加获得心理治疗的机会,并实施多方利益相关者的观点,以了解有抑郁和焦虑症状的围产期人群的需求/偏好。具体来说,这项实用的、非劣效性的随机有效性试验检验了通过远程医疗提供的行为激活(BA)是否与现场治疗一样有效。然而,由于新冠肺炎,该研究暂停了面对面的BA会议,并完全转向远程医疗。为了确保广泛使用BA, SUMMIT团队努力在不久的将来恢复亲自治疗。目的:了解主要利益攸关方对峰会参与者在2019冠状病毒病背景下恢复面对面BA会议的潜在障碍和促进因素的看法。方法:通过Zoom与N=9名利益相关者进行焦点小组讨论(1小时),包括患者维权人士、护士、临床医生和研究人员。使用NVivo对定性数据进行编码,并进行内容分析以量化经常认可的主题。结果:大多数利益相关者认为,在2019冠状病毒病期间,恢复面对面的BA会议是一项挑战,总的来说,障碍比推动者更多。参与者在接受面对面治疗时可能面临的最常见的障碍包括安排儿童保育(n=8;89%)和不适/害怕来医院(n=6;67%)。在COVID-19期间恢复面对面治疗方面,最受广泛认可的促进因素是向参与者明确传达医院和交通安全预防措施(n=7;78%)和在非现场地点进行面对面会议(n=6;67%)。结论:本研究确定了恢复面对面BA会议的关键促进因素,可以提供以下信息:(1)如何恢复面对面BA会议;(2)制定和实施策略,使BA在COVID-19期间更加以患者为中心。目的:了解主要利益攸关方对峰会参与者在2019冠状病毒病背景下恢复面对面BA会议的潜在障碍和促进因素的看法。方法:通过Zoom与N=9名利益相关者进行焦点小组讨论(1小时),包括患者维权人士、护士、临床医生和研究人员。使用NVivo对定性数据进行编码,并进行内容分析以量化经常认可的主题。结果:大多数利益相关者认为,在2019冠状病毒病期间,恢复面对面的BA会议是一项挑战,总的来说,障碍比推动者更多。参与者在接受面对面治疗时可能面临的最常见的障碍包括安排儿童保育(n=8;89%)和不适/害怕来医院(n=6;67%)。在COVID-19期间恢复面对面治疗方面,最受广泛认可的促进因素是向参与者明确传达医院和交通安全预防措施(n=7;78%)和在非现场地点进行面对面会议(n=6;67%)。结论:本研究确定了恢复面对面BA会议的关键促进因素,可以提供以下信息:(1)如何恢复面对面BA会议;(2)制定和实施策略,使BA在COVID-19期间更加以患者为中心。
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引用次数: 0
Gender and Gender-Based Violence 性别与性别暴力
Pub Date : 2021-09-13 DOI: 10.33137/utjph.v2i2.36836
Megan Brown Wollenberg
Action Against Hunger is an international non-governmental organization with six headquarters located around the world that focus on ending hunger in low and middle-income countries. The Canadian office uniquely provides evidenced-based technical support and evaluation for headquarters focused on implementing interventions and programming to mitigate hunger. For my practicum I worked in the International Gender Unit to support ongoing policy development and updating of the organization’s cross-network gender policy. Gender inequalities have direct causal links with malnutrition; yet, in March 2020 the Global Nutrition Report showed that global efforts to mitigate hunger by addressing gender inequalities are behind on most targets. To better capture and learn how to address underlying inequalities and drivers of malnutrition, my practicum research focused on the associations and non-associations between gender, gender-based violence, and malnutrition. This practicum placement had three objectives: 1) to provide a literature review 2) to provide a database comprised of peer-reviewed and grey literature; and, 3) to support new policy development during cross-headquarters discussions, research, and reporting. During this placement I had the opportunity to work online with individuals across five continents and twenty-one countries. This included facilitating break-out policy discussions during policy meetings, as well as semi-structured interviews that were conducted prior to providing a literature review and socio-ecological discussion on gender, gender-based violence and malnutrition. The opportunity to engage in international and cross-cultural collaborative work has been the highlight of my practicum. It has provided the opportunity to not only sharpen my reflexive praxis as a student of public health, but to sharpen my understanding of the policy process at the organizational level. It has additionally illuminated the importance of structural and social contexts in public health research and programming, especially within efforts to address gender inequalities and gender-based violence associated with malnutrition.
“反饥饿行动”是一个国际非政府组织,在世界各地设有六个总部,致力于消除低收入和中等收入国家的饥饿。加拿大办事处独特地为总部提供以证据为基础的技术支持和评价,重点是实施缓解饥饿的干预措施和规划。在我的实习中,我在国际性别股工作,支持正在进行的政策制定和更新该组织的跨网络性别政策。性别不平等与营养不良有直接的因果关系;然而,2020年3月的《全球营养报告》显示,通过解决性别不平等来减轻饥饿的全球努力在实现大多数目标方面落后。为了更好地捕捉和了解如何解决潜在的不平等和营养不良的驱动因素,我的实习研究侧重于性别、基于性别的暴力与营养不良之间的联系和不联系。这个实习安排有三个目标:1)提供文献综述;2)提供一个由同行评议文献和灰色文献组成的数据库;3)在跨总部讨论、研究和报告过程中支持新政策的制定。在此期间,我有机会与来自五大洲和21个国家的个人在线工作。这包括在政策会议期间促进政策讨论,以及在提供关于性别、基于性别的暴力和营养不良的文献综述和社会生态讨论之前进行的半结构化访谈。有机会参与国际和跨文化的合作工作是我实习的亮点。它提供了一个机会,不仅提高了我作为公共卫生学生的反思性实践,而且提高了我对组织层面政策过程的理解。它还阐明了结构和社会背景在公共卫生研究和方案拟订中的重要性,特别是在解决与营养不良有关的两性不平等和基于性别的暴力的努力中。
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引用次数: 0
Challenging the HIV Epidemic in Ontario Through PrEP and HIV Testing 通过预防和艾滋病毒检测挑战安大略省的艾滋病毒流行
Pub Date : 2021-09-13 DOI: 10.33137/utjph.v2i2.36834
S. Winkelman
The Ontario HIV Treatment Network (OHTN) is a non-profit network which collaborates with health clinics, AIDS service and community organizations, and policy leaders in order to improve the health and wellbeing of people living with and at risk of HIV. I joined the OHTN as a member of the Collective Impact team, with a focus on examining the barriers and facilitators to Pre-Exposure Prophylaxis (PrEP) uptake in Ontario. PrEP is a once-daily pill which is highly effective in preventing HIV infections for HIV-negative people, however usage remains relatively low in Ontario. In this role, I liaised with the Knowledge Synthesis team at OHTN to collect, analyse, and synthesize recent scientific literature on Pre and Post-exposure prophylaxis (PEP) in order to create a comprehensive annotated bibliography on PrEP research. Key findings were drawn from the research to identify potential next steps to increase PrEP use for priority populations in Ontario. Findings from the annotated bibliography were presented to OHTN staff, and have been used to assist in the development of two PrEP study proposals; 1) a cisgender and transgender women-focused PrEP education package and HIV risk screening tool, and 2) a pharmacist-led PrEP delivery pilot. I also worked with the Testing and Clinical Initiatives team at the OHTN, to aid in the implementation and evaluation of two HIV-testing projects: the GetaTest pharmacy-based HIV-testing study, and the GetaKit HIV self-testing pilot program. In this role I drafted health communication materials; analysed survey data and drafted project reports for stakeholders; and provided perspectives on the HIV-care continuum, particularly on PrEP initiation, adherence, and efficacy. My work with the OHTN was important to public health because it sought to expand access to HIV testing and prevention services for priority populations in Ontario, including men who have sex with men, and cis and trans women.
安大略艾滋病毒治疗网络(OHTN)是一个非营利性网络,它与保健诊所、艾滋病服务机构和社区组织以及政策领导人合作,以改善艾滋病毒感染者和面临艾滋病毒感染风险者的健康和福祉。我作为集体影响小组的一员加入了OHTN,重点是检查安大略省接触前预防(PrEP)采用的障碍和促进因素。PrEP是一种每天一次的药丸,对HIV阴性的人预防HIV感染非常有效,但在安大略省的使用率仍然相对较低。在此职位上,我与OHTN的知识综合团队联系,收集、分析和综合有关暴露前和暴露后预防(PEP)的最新科学文献,以创建有关暴露前和暴露后预防研究的综合注释书目。从研究中得出了主要发现,以确定在安大略省优先人群中增加PrEP使用的潜在后续步骤。从带注释的参考书目中得出的结论已提交给ohhtn工作人员,并已用于协助拟订两项预防PrEP研究建议;1)以顺性别和跨性别妇女为重点的PrEP教育包和艾滋病毒风险筛查工具,以及2)以药剂师为主导的PrEP交付试点。我还与OHTN的检测和临床倡议小组合作,协助实施和评估两个艾滋病毒检测项目:geatest基于药物的艾滋病毒检测研究和GetaKit艾滋病毒自我检测试点项目。在这个职位上,我起草了卫生宣传材料;分析调查数据,为利益相关者起草项目报告;并提供了关于艾滋病毒护理连续性的观点,特别是关于PrEP的开始,坚持和疗效。我在OHTN的工作对公共卫生很重要,因为它试图扩大安大略省重点人群获得艾滋病毒检测和预防服务的机会,包括男男性行为者以及顺性和变性妇女。
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引用次数: 0
Reliability of Donor Lung Sampling in Lung Transplantation 肺移植中供肺取样的可靠性
Pub Date : 2021-09-05 DOI: 10.33137/utjph.v2i2.36828
B. T. Chao, A. Sage, M. Cypel, Mingyao Liu, J. Yeung, X. Bai, D. Van raemdonck, L. Ceulemans, A. Neyrinck, S. Verleden, S. Keshavjee
Introduction: Ex vivo lung perfusion (EVLP) is a normothermic platform used to assess donor lungs. Many have studied biomarkers in lung injury, but it is unclear whether samples taken from one location are representative of the organ. Our objective was to investigate the uniformity of cytokine expression in tissue biopsies and in EVLP perfusates from various locations. Methods: In the tissue study, eight donor lungs were partitioned from apex to base. In each lung, three biopsies were taken from the third, sixth, and ninth slices, while two were taken from the lingula and an injury site. In the perfusate study, four samples were taken from four lobes in eight donors during EVLP. Expressions of IL-6, IL-8, IL-10, and IL-1β were measured using qPCR and ELISA. Results: In the tissue study, the mean intra-biopsy equal-variance F-value was 0.53. The median intra-biopsy coefficient of variation (CV) was 18%. In donors without gross focal injury, the mean comparisons of biopsies in each donor showed that the three consistent slices showed no differences and had a CV of 20%, which was similar to the intra-biopsy CV (p=0.80). Both the lingula and injury biopsies demonstrated larger differences from the rest. The median intra-lung CV of perfusates from different lobes was 4.9%. Conclusion: Intra-biopsy variances were consistent across biopsies. Lungs without gross focal injury demonstrated more consistent gene expression. The lingula is not a representative site due to high signal variability. The consistent measurements in EVLP perfusates provided a uniform picture of the inflammation.
体外肺灌注(EVLP)是一种用于评估供体肺的常温平台。许多人研究了肺损伤的生物标志物,但尚不清楚从一个地方采集的样本是否代表该器官。我们的目的是研究组织活检和不同部位EVLP灌注物中细胞因子表达的均匀性。方法:在组织研究中,8个供肺由尖向底分割。在每个肺中,分别从第三、第六和第九片取3个活检组织,同时从舌部和损伤部位取2个活检组织。在灌注研究中,在EVLP期间从8名供者的4个肺叶中采集了4个样本。采用qPCR和ELISA检测IL-6、IL-8、IL-10和IL-1β的表达。结果:在组织研究中,平均活检内等方差f值为0.53。活检内变异系数(CV)中位数为18%。在没有明显局灶性损伤的供者中,每个供者活检的平均比较显示,三个一致切片没有差异,CV为20%,与活检内CV相似(p=0.80)。舌部和损伤活检显示与其他部位有较大差异。不同肺叶灌注液的中位肺内CV为4.9%。结论:活检内的差异在活检中是一致的。没有明显局灶性损伤的肺表现出更一致的基因表达。由于高信号变异性,舌部并不是一个具有代表性的部位。EVLP灌注液的一致测量提供了炎症的统一图像。
{"title":"Reliability of Donor Lung Sampling in Lung Transplantation","authors":"B. T. Chao, A. Sage, M. Cypel, Mingyao Liu, J. Yeung, X. Bai, D. Van raemdonck, L. Ceulemans, A. Neyrinck, S. Verleden, S. Keshavjee","doi":"10.33137/utjph.v2i2.36828","DOIUrl":"https://doi.org/10.33137/utjph.v2i2.36828","url":null,"abstract":"Introduction: Ex vivo lung perfusion (EVLP) is a normothermic platform used to assess donor lungs. Many have studied biomarkers in lung injury, but it is unclear whether samples taken from one location are representative of the organ. Our objective was to investigate the uniformity of cytokine expression in tissue biopsies and in EVLP perfusates from various locations. \u0000Methods: In the tissue study, eight donor lungs were partitioned from apex to base. In each lung, three biopsies were taken from the third, sixth, and ninth slices, while two were taken from the lingula and an injury site. In the perfusate study, four samples were taken from four lobes in eight donors during EVLP. Expressions of IL-6, IL-8, IL-10, and IL-1β were measured using qPCR and ELISA. \u0000Results: In the tissue study, the mean intra-biopsy equal-variance F-value was 0.53. The median intra-biopsy coefficient of variation (CV) was 18%. In donors without gross focal injury, the mean comparisons of biopsies in each donor showed that the three consistent slices showed no differences and had a CV of 20%, which was similar to the intra-biopsy CV (p=0.80). Both the lingula and injury biopsies demonstrated larger differences from the rest. The median intra-lung CV of perfusates from different lobes was 4.9%. \u0000Conclusion: Intra-biopsy variances were consistent across biopsies. Lungs without gross focal injury demonstrated more consistent gene expression. The lingula is not a representative site due to high signal variability. The consistent measurements in EVLP perfusates provided a uniform picture of the inflammation.","PeriodicalId":265882,"journal":{"name":"University of Toronto Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123616579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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University of Toronto Journal of Public Health
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