Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102757
Yuan Liang , Shuang-Feng Song , Siyu Liu , Zhi-Liang Shen , Xiao-Feng Wu
In the July 17 issue of Science, Lu et al. disclose a strategy for converting abundant pyrrolidines into tetrahydropyridazines via a nitrogen-atom insertion process with O-diphenylphosphinyl hydroxylamine as the nitrogen source, providing a powerful platform for the rapid construction of a variety of nitrogen-containing diazacycles and the late-stage derivatization of drug-like molecules.
{"title":"Nitrogen-atom insertion enables skeletal editing of pyrrolidines for tetrahydropyridazine synthesis","authors":"Yuan Liang , Shuang-Feng Song , Siyu Liu , Zhi-Liang Shen , Xiao-Feng Wu","doi":"10.1016/j.chempr.2025.102757","DOIUrl":"10.1016/j.chempr.2025.102757","url":null,"abstract":"<div><div>In the July 17 issue of <em>Science</em>, Lu et al. disclose a strategy for converting abundant pyrrolidines into tetrahydropyridazines via a nitrogen-atom insertion process with <em>O</em>-diphenylphosphinyl hydroxylamine as the nitrogen source, providing a powerful platform for the rapid construction of a variety of nitrogen-containing diazacycles and the late-stage derivatization of drug-like molecules.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102757"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102783
Merve Temel , Stefano Crespi
In this issue of Chem, Wu and Greenfield demonstrate how a light-fueled information ratchet in a photoswitchable imine pair shifts the composition of free amines to drive a non-photoresponsive transimination out of equilibrium. The ratchet thus establishes a nonequilibrium steady state in homogeneous solution and provides a blueprint for light-controlled reaction cascades.
{"title":"Lighting up dark reactions: An imine network ratchets a coupled equilibrium","authors":"Merve Temel , Stefano Crespi","doi":"10.1016/j.chempr.2025.102783","DOIUrl":"10.1016/j.chempr.2025.102783","url":null,"abstract":"<div><div>In this issue of <em>Chem</em>, Wu and Greenfield demonstrate how a light-fueled information ratchet in a photoswitchable imine pair shifts the composition of free amines to drive a non-photoresponsive transimination out of equilibrium. The ratchet thus establishes a nonequilibrium steady state in homogeneous solution and provides a blueprint for light-controlled reaction cascades.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102783"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145141060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102586
Yanyan Wang , Kuohong Chen , Fengrui Che , Sha Zhao , Pinpin Feng , Qiang Zhao , Donghui Wei , Xingxing Wu , Yonggui Robin Chi
Despite various impressive advancements in the construction of chiral phosphorus centers, enantioselective control of P(V)-stereogenicity with covalent nucleophilic catalysts for direct preparation of chiral phosphorus compounds remains relatively underdeveloped. Here, we disclose a new mode of covalent organocatalysis for enantioselective construction of chiral phosphorus scaffolds via new P–O bond formations. Key steps in our approach involve the addition of an N-heterocyclic carbene (NHC) catalyst to a phosphonate, leading to the formation of a pivotal phosphonyl azolium reactive intermediate that effectively forges the asymmetric P–O bond formation in high selectivity. The resulting phosphonate products bearing a leaving group allow further stereospecific P–O/N coupling, facilitating the phosphonylated functionalization of diverse natural products and bioactive molecules. Unlike classical NHC organocatalysis that focuses on “C”-stereocenters, this study realizes efficient catalyst control over P(V)-stereogenicity through phosphorus-based azolium intermediates for the first time, offering a new platform for covalent bond activation in the synthesis of stereogenic phosphorus compounds.
{"title":"NHC-catalyzed covalent activation and control of P(V)-stereogenic phosphorus centers via phosphonyl azolium intermediates","authors":"Yanyan Wang , Kuohong Chen , Fengrui Che , Sha Zhao , Pinpin Feng , Qiang Zhao , Donghui Wei , Xingxing Wu , Yonggui Robin Chi","doi":"10.1016/j.chempr.2025.102586","DOIUrl":"10.1016/j.chempr.2025.102586","url":null,"abstract":"<div><div><span>Despite various impressive advancements in the construction of chiral phosphorus centers, enantioselective control of P(V)-stereogenicity with covalent nucleophilic catalysts for direct preparation of chiral phosphorus compounds remains relatively underdeveloped. Here, we disclose a new mode of covalent organocatalysis for enantioselective construction of chiral phosphorus scaffolds via new P–O bond formations. Key steps in our approach involve the addition of an </span><em>N</em><span><span>-heterocyclic carbene (NHC) catalyst to a phosphonate, leading to the formation of a pivotal phosphonyl azolium reactive intermediate that effectively forges the asymmetric P–O bond formation in high selectivity. The resulting phosphonate products bearing a leaving group allow further stereospecific P–O/N coupling, facilitating the phosphonylated functionalization of diverse </span>natural products<span> and bioactive molecules. Unlike classical NHC organocatalysis that focuses on “C”-stereocenters, this study realizes efficient catalyst control over P(V)-stereogenicity through phosphorus-based azolium intermediates for the first time, offering a new platform for covalent bond activation in the synthesis of stereogenic phosphorus compounds.</span></span></div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102586"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102779
Zheng Zhu , Yangjian Quan
Although the asymmetric synthesis of enantioenriched carborane derivatives has been disclosed, the homochiral carborane-fused polyarene remains synthetically elusive. In the September issue of Cell Reports Physical Science, Mu and co-workers report the modular synthesis of various boraphenanthrenes containing carborane blocks. Mechanistic studies show that the key steps are the transfer of axial chirality and an unusual 1,2-boron migration.
{"title":"Unlocking the synthesis of homochiral carborane-fused boraphenanthrenes","authors":"Zheng Zhu , Yangjian Quan","doi":"10.1016/j.chempr.2025.102779","DOIUrl":"10.1016/j.chempr.2025.102779","url":null,"abstract":"<div><div>Although the asymmetric synthesis of enantioenriched carborane derivatives has been disclosed, the homochiral carborane-fused polyarene remains synthetically elusive. In the September issue of <em>Cell Reports Physical Science</em>, Mu and co-workers report the modular synthesis of various boraphenanthrenes containing carborane blocks. Mechanistic studies show that the key steps are the transfer of axial chirality and an unusual 1,2-boron migration.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102779"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102579
Jiarong Wu (邬佳蓉) , Jake L. Greenfield
Driving non-photoresponsive transformations out of equilibrium with light requires transducing light energy into a different stimulus. Here, we demonstrate this using a dynamic-covalent network of four interconverting imines. In this system, photoirradiation drives a transimination reaction involving photoswitchable imines into a non-equilibrium steady state, altering the composition of both the photochromic imines and free amines. This shift in amine composition subsequently perturbs a coupled transimination reaction that does not directly absorb this wavelength of light. Notably, coupling these two reactions enhances the system’s response; the amines generated in each transimination facilitate the other, amplifying the overall departure from equilibrium beyond what is observed for the reactions in isolation. Operating entirely in solution, this light-fueled cascade provides a blueprint for designing dynamic-covalent systems that harness light energy to control non-photoresponsive transformations, expanding the scope and complexity of light-driven processes in systems chemistry.
{"title":"Harnessing light to drive a non-photoresponsive reaction out of equilibrium","authors":"Jiarong Wu (邬佳蓉) , Jake L. Greenfield","doi":"10.1016/j.chempr.2025.102579","DOIUrl":"10.1016/j.chempr.2025.102579","url":null,"abstract":"<div><div>Driving non-photoresponsive transformations out of equilibrium with light requires transducing light energy into a different stimulus. Here, we demonstrate this using a dynamic-covalent network of four interconverting imines. In this system, photoirradiation drives a transimination reaction involving photoswitchable imines into a non-equilibrium steady state, altering the composition of both the photochromic imines and free amines. This shift in amine composition subsequently perturbs a coupled transimination reaction that does not directly absorb this wavelength of light. Notably, coupling these two reactions enhances the system’s response; the amines generated in each transimination facilitate the other, amplifying the overall departure from equilibrium beyond what is observed for the reactions in isolation. Operating entirely in solution, this light-fueled cascade provides a blueprint for designing dynamic-covalent systems that harness light energy to control non-photoresponsive transformations, expanding the scope and complexity of light-driven processes in systems chemistry.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102579"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102582
Sebastian Brosch , Eike Häger , Ole Frank , Patrick Scholz , Wenzel Plischka , Matthias Wessling
Electrochemical CO2 reduction represents a promising technology for mitigating the impact of greenhouse gas emissions, particularly CO2. Gas diffusion electrodes (GDEs) are widely utilized in this process. Although CO2 reduction has been successfully demonstrated on small scales with various catalysts, the role of the wetting state of the catalyst layer in GDEs remains poorly understood. This factor significantly influences current density and faradaic efficiency. However, two fundamental questions persist: where within the electrode does the desired reaction occur, and what operating state should be targeted for optimizing performance? In this study, we employ a microfluidic electrolyzer to visualize and selectively identify reaction zones producing CO, the desired product. This approach enables the characterization of reactivity across different states of the electrode, revealing the impact of catalyst-layer wetting on product selectivity. Together with our previous research on GDEs, these findings provide a comprehensive understanding of electrochemical CO2 reduction.
{"title":"Visualization of CO formation at the triple-phase boundary in gas diffusion electrodes for ecCO2RR","authors":"Sebastian Brosch , Eike Häger , Ole Frank , Patrick Scholz , Wenzel Plischka , Matthias Wessling","doi":"10.1016/j.chempr.2025.102582","DOIUrl":"10.1016/j.chempr.2025.102582","url":null,"abstract":"<div><div>Electrochemical CO<sub>2</sub> reduction represents a promising technology for mitigating the impact of greenhouse gas emissions, particularly CO<sub>2</sub>. Gas diffusion electrodes (GDEs) are widely utilized in this process. Although CO<sub>2</sub> reduction has been successfully demonstrated on small scales with various catalysts, the role of the wetting state of the catalyst layer in GDEs remains poorly understood. This factor significantly influences current density and faradaic efficiency. However, two fundamental questions persist: where within the electrode does the desired reaction occur, and what operating state should be targeted for optimizing performance? In this study, we employ a microfluidic electrolyzer to visualize and selectively identify reaction zones producing CO, the desired product. This approach enables the characterization of reactivity across different states of the electrode, revealing the impact of catalyst-layer wetting on product selectivity. Together with our previous research on GDEs, these findings provide a comprehensive understanding of electrochemical CO<sub>2</sub> reduction.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102582"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102654
Chensen Li , Minghui Wu , Zheng Zhao , Jacky W.Y. Lam , Bo Xu , Ben Zhong Tang
Organic room-temperature phosphorescence (RTP) emitters have emerged as a compelling research field with broad applications in optoelectronics, anti-counterfeiting, and biomedical imaging. This interest stems from the efficient utilization of the radiative relaxation of the triplet excited state. An efficient intersystem crossing (ISC) process alone is not sufficient for efficient and long-lived RTP emission. It is also crucial to suppress molecular motion, including rotation, vibration, and translation. By rigidifying molecular structures to suppress these motions, triplet excitons are effectively stabilized, and non-radiative transitions are reduced, presenting a viable strategy for developing a variety of efficient and long-lived RTP materials. This review focuses on the current rational engineering efforts to suppress molecular motion for efficient and long-lived RTP generation, enhancing understanding of the interplay between molecular motion and RTP emission, and emphasizing the critical role of restricting molecular motion in the development of efficient and long-lived RTP materials.
{"title":"Suppressing molecular motions: A pathway to enhanced organic room-temperature phosphorescence","authors":"Chensen Li , Minghui Wu , Zheng Zhao , Jacky W.Y. Lam , Bo Xu , Ben Zhong Tang","doi":"10.1016/j.chempr.2025.102654","DOIUrl":"10.1016/j.chempr.2025.102654","url":null,"abstract":"<div><div><span>Organic room-temperature phosphorescence (RTP) emitters have emerged as a compelling research field with broad applications in optoelectronics, anti-counterfeiting, and biomedical imaging. This interest stems from the efficient utilization of the radiative relaxation of the </span>triplet excited state<span>. An efficient intersystem crossing (ISC) process alone is not sufficient for efficient and long-lived RTP emission. It is also crucial to suppress molecular motion, including rotation, vibration, and translation. By rigidifying molecular structures to suppress these motions, triplet excitons are effectively stabilized, and non-radiative transitions are reduced, presenting a viable strategy for developing a variety of efficient and long-lived RTP materials. This review focuses on the current rational engineering efforts to suppress molecular motion for efficient and long-lived RTP generation, enhancing understanding of the interplay between molecular motion and RTP emission, and emphasizing the critical role of restricting molecular motion in the development of efficient and long-lived RTP materials.</span></div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102654"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since the bioactivity of nanomedicines is intrinsically governed by their structural configuration, selenium nanoparticles (SeNPs) exhibit structure-dependent therapeutic efficacy in diverse biomedical domains spanning oncology, redox homeostasis regulation, immunomodulation, antimicrobial therapy, and regenerative therapy. However, their inherent dynamic instability and unclear chemical structure pose significant challenges in elucidating their action mechanisms, consequently impeding clinical translation, with current therapeutic applications remaining in their nascent stages. This perspective will delve into the synthetic strategies, structure-activity relationships, and biomedical applications of SeNPs while providing insights into the underlying connection between structure-driven therapeutic optimization and clinical translation.
{"title":"Structure-driven medicinal applications of selenium nanoparticles: Challenges and opportunities in clinical translation","authors":"Zushuang Xiong , Yanzi Yu , Lizhen He , Tianfeng Chen","doi":"10.1016/j.chempr.2025.102684","DOIUrl":"10.1016/j.chempr.2025.102684","url":null,"abstract":"<div><div>Since the bioactivity of nanomedicines is intrinsically governed by their structural configuration, selenium nanoparticles (SeNPs) exhibit structure-dependent therapeutic efficacy in diverse biomedical domains spanning oncology, redox homeostasis regulation, immunomodulation, antimicrobial therapy, and regenerative therapy. However, their inherent dynamic instability and unclear chemical structure pose significant challenges in elucidating their action mechanisms, consequently impeding clinical translation, with current therapeutic applications remaining in their nascent stages. This perspective will delve into the synthetic strategies, structure-activity relationships, and biomedical applications of SeNPs while providing insights into the underlying connection between structure-driven therapeutic optimization and clinical translation.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102684"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102786
Binbin Xu , Dafa Chen , Haiping Xia
Metallaaromatics represent a distinct class of aromatic systems wherein at least one metal atom is structurally integrated into the conjugated π-framework of the aromatic ring structure. Carbolong complexes, one of the primary types, feature one metal center occupying the bridgehead position of at least two fused five-membered rings. This Backstory outlines the development process from carbolong complexes to in-plane metallo-annulenes, metallaaromatics in which the metal occupies the planar annulene cavity, and highlights the interplay between serendipitous discovery and rational design.
{"title":"A journey from carbolong complexes to in-plane metallo-annulenes","authors":"Binbin Xu , Dafa Chen , Haiping Xia","doi":"10.1016/j.chempr.2025.102786","DOIUrl":"10.1016/j.chempr.2025.102786","url":null,"abstract":"<div><div>Metallaaromatics represent a distinct class of aromatic systems wherein at least one metal atom is structurally integrated into the conjugated π-framework of the aromatic ring structure. Carbolong complexes, one of the primary types, feature one metal center occupying the bridgehead position of at least two fused five-membered rings. This Backstory outlines the development process from carbolong complexes to in-plane metallo-annulenes, metallaaromatics in which the metal occupies the planar annulene cavity, and highlights the interplay between serendipitous discovery and rational design.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102786"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.chempr.2025.102571
Bipin Pandey , Bharadwaj Muralidharan , Tianmu Ma , Akshi Pant , Matthew Onorato , Kenneth A. Johnson , Ananth Dodabalapur , Praveen Pasupathy , Eric V. Anslyn
The growing demand for data storage has driven research into alternative storage media. Although DNA has proven effective, synthetic sequence-defined polymers (SDPs) offer tailored information-encoding potential. Despite advances in SDP chemodiversity, sequencing methods remain limited, primarily relying on tandem mass spectrometry. To address this, we developed an electrochemical sequencing technique for sequence-defined oligourethanes (SDOs), incorporating four ferrocene-based monomers. Our method combines controlled chain-end degradation with differential pulse voltammetry (DPV) to yield unique voltammograms specific to each sequence. Coupled with kinetic modeling and principal component analysis (PCA), this approach enables accurate sequence identification. We automated this process with a Python program that decodes sequences by comparing experimental DPV data to predicted profiles and thereby successfully demonstrated the encoding and decoding of an 11-character password. The technique expands the toolbox for sequencing SDPs and opens new possibilities for molecular data storage.
{"title":"Electrochemical sequencing of sequence-defined ferrocene-containing oligourethanes","authors":"Bipin Pandey , Bharadwaj Muralidharan , Tianmu Ma , Akshi Pant , Matthew Onorato , Kenneth A. Johnson , Ananth Dodabalapur , Praveen Pasupathy , Eric V. Anslyn","doi":"10.1016/j.chempr.2025.102571","DOIUrl":"10.1016/j.chempr.2025.102571","url":null,"abstract":"<div><div>The growing demand for data storage has driven research into alternative storage media. Although DNA has proven effective, synthetic sequence-defined polymers (SDPs) offer tailored information-encoding potential. Despite advances in SDP chemodiversity, sequencing methods remain limited, primarily relying on tandem mass spectrometry. To address this, we developed an electrochemical sequencing technique for sequence-defined oligourethanes (SDOs), incorporating four ferrocene-based monomers. Our method combines controlled chain-end degradation with differential pulse voltammetry (DPV) to yield unique voltammograms specific to each sequence. Coupled with kinetic modeling and principal component analysis (PCA), this approach enables accurate sequence identification. We automated this process with a Python program that decodes sequences by comparing experimental DPV data to predicted profiles and thereby successfully demonstrated the encoding and decoding of an 11-character password. The technique expands the toolbox for sequencing SDPs and opens new possibilities for molecular data storage.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 10","pages":"Article 102571"},"PeriodicalIF":19.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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