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2019 IEEE Healthcare Innovations and Point of Care Technologies, (HI-POCT)最新文献

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Integrated Point-of-Care Device for Anemia Detection and Hemoglobin Variant Identification 用于贫血检测和血红蛋白变异识别的综合护理点设备
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962876
R. An, M. N. Hasan, Yuncheng Man, U. Gurkan
Anemia affects more than 2 billion people worldwide, which is about 25% of the world’s population. Anemia has numerous causes ranging from nutritional deficiencies, drugs, chronic conditions that indirectly cause anemia as well as primary hematologic diseases. Among the various causes of anemia world-wide, hemoglobinopathies, including Sickle Cell Disease (SCD) and Thalassemia, are the 3rd most prevalent after iron-deficiency anemia and hookworm disease. Anemia and SCD diagnosis/monitoring are challenging in low and middle income countries due to lack of laboratory infrastructure and skilled personnel as well as insufficient financial resources. We extended our previously established HemeChip system to add total hemoglobin quantification and anemia testing capability. HemeChip+ is mass-producible at low cost and offers the first and only single test point-of-care (POC) platform for portable, affordable, and accurate, hemoglobin quantification, anemia detection, and hemoglobin variant identification.
全世界有超过20亿人患有贫血,约占世界人口的25%。贫血有多种原因,包括营养缺乏、药物、间接导致贫血的慢性疾病以及原发性血液病。在全世界引起贫血的各种原因中,血红蛋白病,包括镰状细胞病(SCD)和地中海贫血,是继缺铁性贫血和钩虫病之后的第三大流行疾病。由于缺乏实验室基础设施和熟练人员以及财政资源不足,贫血和SCD诊断/监测在低收入和中等收入国家具有挑战性。我们扩展了之前建立的HemeChip系统,增加了总血红蛋白定量和贫血测试能力。HemeChip+可以低成本批量生产,并提供第一个也是唯一一个便携式、经济实惠、准确的血红蛋白定量、贫血检测和血红蛋白变异鉴定的单点检测平台。
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引用次数: 3
Smartphone Based Microfluidic Biosensor for Leukocyte Quantification at the Point-of-Care 基于智能手机的白细胞定量微流控生物传感器
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962697
M. Sami, Kurt Wagner, P. Parikh, U. Hassan
The architecture and working of a smartphone-based biosensor for the quantification of leukocytes at point of care is presented in this paper. The biosensor consists of a microscopic smartphone attachment with a resolution of 6.2 μm and a disposable microfluidic biochip for capturing leukocytes. Polymorphonuclear leukocytes (PMNL) were isolated from whole blood before being seeded into PBS solution to mimic the biological samples from patients suffering from various diseases. To capture all the leukocytes, antihuman CD45 antibody was immobilized in the capture chamber of microfluidic biochip for one hour for adsorption. Leukocyte spiked PBS sample was then flowed through the microfluidic biochip at 10 μl/min for capturing leukocytes. 50 μl of a green nuclear stain was then flowed through the biochip for fluorescent imaging. Leukocyte capture was verified by imaging the biochip in the smartphone setup. ImageJ was then used for detection and quantification of leukocytes from the captured images. The obtained results showcase the feasibility of this setup for detection of multiple biomarkers from different body fluids at point of care.
本文介绍了基于智能手机的生物传感器的结构和工作,用于在护理点量化白细胞。该生物传感器由分辨率为6.2 μm的微型智能手机附件和用于捕获白细胞的一次性微流控生物芯片组成。从全血中分离出多形核白细胞(PMNL),然后将其植入PBS溶液中模拟各种疾病患者的生物样本。为了捕获所有的白细胞,将抗人CD45抗体固定在微流控生物芯片的捕获室中1小时进行吸附。将加入白细胞的PBS样品以10 μl/min的速度流过微流控生物芯片,捕获白细胞。然后用50 μl的绿色核染色液流过生物芯片进行荧光成像。通过在智能手机设置中成像生物芯片来验证白细胞捕获。然后使用ImageJ从捕获的图像中检测和定量白细胞。所获得的结果表明,在护理点检测来自不同体液的多种生物标志物的这种设置的可行性。
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引用次数: 5
HI-POCT 2019 Keynote Speakers HI-POCT 2019主题演讲嘉宾
Pub Date : 2019-11-01 DOI: 10.1109/hi-poct45284.2019.8962893
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引用次数: 0
Deep Learning of Biomechanical Dynamics in Mobile Daily Activity and Fall Risk Monitoring* 移动日常活动和跌倒风险监测中的生物力学动力学深度学习*
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962763
Qingxue Zhang
Smart health is paving a promising way for modern health management. Daily activity and fall risk monitoring is one important application that urges smart technologies, resulting from the fact that there are 29 million falls and 7 million fall injuries per year, and also the fact that appropriate exercise can lower the risk of death by up to 20 to 70%. However, it is very challenging to accurately identify an activity due to the diversity of the human biomechanical dynamics. Main reasons include: even a same person usually has different motion characteristics when performing a same activity; there are many different activities in our daily lives; and the sensor wearing habit may be different. In this paper, focusing on these challenges, a new intelligent computational approach is proposed for robust activity detection, leveraging biomechanical dynamics enhancement and deep learning technologies. It can unveil deep hidden biomechanical patterns from the mobile phone-sensed motion data, and robustly detect 17 types of daily and fall activities performed by 30 people. The detection accuracy of 11,770 activities is as high as 93.9%, indicating the effectiveness of the proposed approach. This research is expected to greatly advance mobile daily activity and fall risk monitoring in smart health era.
智能健康为现代健康管理开辟了广阔的道路。日常活动和跌倒风险监测是推动智能技术的一个重要应用,因为每年有2900万次跌倒和700万次跌倒受伤,而且适当的运动可以将死亡风险降低20%至70%。然而,由于人体生物力学动力学的多样性,准确识别一种活动是非常具有挑战性的。主要原因包括:即使是同一个人,在进行相同的活动时,通常也会有不同的运动特征;在我们的日常生活中有许多不同的活动;而传感器的佩戴习惯可能会有所不同。在本文中,针对这些挑战,提出了一种新的智能计算方法,用于鲁棒活动检测,利用生物力学动力学增强和深度学习技术。它可以从手机感知的运动数据中揭示隐藏的深层生物力学模式,并对30人进行的17种日常和跌倒活动进行强大的检测。11770个活动的检测准确率高达93.9%,表明该方法的有效性。这项研究有望极大地推动智能健康时代的移动日常活动和跌倒风险监测。
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引用次数: 4
All-ECG: A Least-number of Leads ECG Monitor for Standard 12-lead ECG Tracking during Motion* 全心电图:最少数量的导联心电图监护仪标准12导联心电图跟踪运动期间*
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962742
Qingxue Zhang, Kyle Frick
As a leading cause of death, cardiac diseases are taking away lives from over a half million US people each year. Standard 12-lead electrocardiogram (ECG) signals are gold-standard cardiac vital signs, and have been widely used in clinics and hospitals. However, it is still not readily available in our daily lives, due to its inconvenient and uncomfortable setting, as well as large signal quality degradation during our daily motions. In this research, a novel ECG monitor called, All-ECG, is proposed, which is expected to, at the same time, provide a convenient setting and enable motion-tolerant 12-lead ECG tracking. To achieve the first goal – convenience, a least-number of leads are selected to reconstruct the remaining leads. To achieve the second goal – robustness, a deep learning framework based on the long short-term memory is developed to reconstruct high quality ECG leads from noisy ECG leads. Evaluated on patient ECG data, the proposed deep learning framework can effectively reconstruct standard 12-lead ECG only from noisy 3-lead ECG during daily motions, with a correlation coefficient of as high as 0.82 and a root mean square error of 0.073 mV. To the best of our knowledge, this is the first study on 12-lead ECG reconstruction from a least-number of noisy leads, and is expected to greatly advance long-term daily heart health management.
作为死亡的主要原因,心脏病每年夺走50多万美国人的生命。标准12导联心电图(ECG)信号是心脏生命体征的金标准,已广泛应用于诊所和医院。然而,由于它的不方便和不舒服的设置,以及在我们的日常运动中信号质量的大下降,它仍然不容易在我们的日常生活中使用。本研究提出了一种新型心电监护仪——All-ECG,该监护仪在提供方便设置的同时,有望实现运动耐受的12导联心电跟踪。为了实现第一个目标——方便,选择最少数量的引线来重建剩余的引线。为了实现第二个目标——鲁棒性,开发了一种基于长短期记忆的深度学习框架,从有噪声的心电导联中重建高质量的心电导联。通过对患者心电数据的评估,所提出的深度学习框架仅能有效地从日常运动时的噪声3导联心电重构标准12导联心电,相关系数高达0.82,均方根误差为0.073 mV。据我们所知,这是第一个用最少数量的噪声导联重建12导联心电图的研究,有望极大地推进长期的日常心脏健康管理。
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引用次数: 13
Daily Locomotor Movement Recognition with a Smart Insole and a Pre-defined Route Map: Towards Early Motor Dysfunction Detection* 每日运动识别与智能鞋垫和预先定义的路线图:迈向早期运动功能障碍检测*
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962654
Rui Hua, Ya Wang
Motor dysfunction, a well-known early sign of neurodegenerative diseases, is occurring to seniors at a growing rate and affects their physical capability of independent living if not treated effectively. The symptoms of motor dysfunction are hard to notice at early stages and can deteriorate in the long term. Thus, it is desirable to detect motor function changes in daily life in a noninvasive manner. This paper aims to accomplish this goal by proposing a method to auto-recognize nine types of daily activities from continuous movements with the use of a smart insole and a pre-designed route map. The route map creates a semi-controlled environment to help the subjects take actions comfortably and behave in experiments as they do in real life. The nine types of highly similar activities are selected from the motor examination and the balance evaluation system test. Preliminary experiments were done with four subjects with controlled and uncontrolled data collection. Four supervised machine learning classifiers are evaluated and compared for classification performance with a 2s window and different overlaps. With regards to the performance and robustness of classifiers, the Random Forest classifier trained with Mix Dataset shows the best results with an averaged classification accuracy of 98.19% in model training, 92.67% in cross-validation and 83.87% in prediction. The results show that it is feasible to recognize these nine activities from daily locomotor movement and further extract parameters of interest from activity periods for early motor dysfunction detection.
运动功能障碍是众所周知的神经退行性疾病的早期症状,老年人的发病率越来越高,如果不加以有效治疗,将影响他们独立生活的身体能力。运动功能障碍的症状在早期很难注意到,并可能在长期恶化。因此,以无创方式检测日常生活中的运动功能变化是可取的。为了实现这一目标,本文提出了一种方法,通过使用智能鞋垫和预先设计的路线图,从连续的运动中自动识别九种类型的日常活动。路线图创造了一个半受控的环境,以帮助受试者在实验中舒适地采取行动,并表现得像他们在现实生活中一样。从运动检查和平衡评价系统测试中选择9种高度相似的活动。初步实验有4名受试者,数据收集有控制和无控制。评估和比较了四个监督机器学习分类器的分类性能,其中有一个2s窗口和不同的重叠。在分类器的性能和鲁棒性方面,使用Mix Dataset训练的Random Forest分类器效果最好,模型训练的平均分类准确率为98.19%,交叉验证的平均分类准确率为92.67%,预测的平均分类准确率为83.87%。结果表明,从日常运动运动中识别出这9种活动,并进一步从活动周期中提取出感兴趣的参数,用于早期运动功能障碍检测是可行的。
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引用次数: 2
Performance Assessment of Machine Learning Based Models for Diabetes Prediction 基于机器学习的糖尿病预测模型的性能评估
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962811
R. Deo, S. Panigrahi
Diabetes is a major chronic disease which impacts all age groups. It has increasing prevalence worldwide. Certain factors increase the chances of diabetes occurrence in individuals. Prediction-based modeling has been used previously to provide a prevention based approach to diabetes. Prediction models have predominantly been based on regression and feature elimination. In this paper, a machine learning-based approach is presented to predict the individual diabetes occurrence based on specific lifestyle, and demographic factors. A publicly available dataset - continuous NHANES, was used. To account for small data size due to missing data and class imbalanced data, certain statistical techniques were applied. Synthetic minority over sampling technique was used via Gower’s distance calculation to avoid class imbalanced data. Additionally, principal component analysis was used as a feature extraction technique. Predictive models were developed using MATLAB. A dataset with 140 data samples and 11 predictor variables (converted to eight principal components) was used. The output variable had two classes - diabetic and not diabetic. A training data set of 98 and 42 samples for training and testing respectively. Two machine learning models - bagged trees and linear SVM were developed. Two validation techniques - 5- fold cross validation and holdout validation were assessed. The highest accuracy of 91% (90.82%, on test data) was obtained by the linear SVM model using both 5-fold cross validation and hold out validation approaches (AUC of 0.908 in both cases).
糖尿病是一种影响所有年龄组的主要慢性疾病。它在世界范围内越来越流行。某些因素会增加个体患糖尿病的几率。基于预测的建模以前已用于提供基于预防的糖尿病方法。预测模型主要是基于回归和特征消除。本文提出了一种基于机器学习的方法,基于特定的生活方式和人口因素来预测个体糖尿病的发生。使用了一个公开可用的数据集-连续NHANES。为了解释由于缺失数据和类别不平衡数据而导致的小数据量,应用了某些统计技术。通过Gower距离计算,采用合成少数过抽样技术,避免了数据的类不平衡。此外,采用主成分分析作为特征提取技术。利用MATLAB开发预测模型。使用了包含140个数据样本和11个预测变量(转换为8个主成分)的数据集。输出变量分为糖尿病和非糖尿病两类。训练数据集有98个样本和42个样本,分别用于训练和测试。提出了袋装树和线性支持向量机两种机器学习模型。评估了两种验证技术- 5倍交叉验证和保留验证。线性支持向量机模型使用5倍交叉验证和hold out验证方法(两种情况下的AUC均为0.908)获得了91%(90.82%,测试数据)的最高准确率。
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引用次数: 6
Motion and Noise Artifact Detection in Smartphone Photoplethysmograph Signals Using Personalized Classifier 基于个性化分类器的智能手机光容积脉搏波信号运动和噪声伪影检测
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962833
F. Tabei, B. Askarian, J. Chong
Health parameters such as heart rhythm, blood pressure, and the level of oxygen saturation in the blood could be measured with photoplethysmography (PPG) signal. The advent of smartphone camera sensors has enabled the extraction of PPG signals from smartphones. PPG signals are weak at motion and noise artifacts (MNA) which could generate unreliable heart rate measurement. Smartphone PPG signals are more prone to MNA since they are not designed for clinical applications. PPG signals are known as biometric signals since they have unique behaviors for each individual. However, in previous MNA detection studies this personalized characteristic has not been considered. In this paper, we propose a novel personalized MNA detection method by applying a probabilistic neural network as a classifier. The performance of our personalized method is evaluated with 25 volunteered subjects in terms of accuracy, specificity, and sensitivity and compared with the generalized method. The average accuracy of our personalized method is 97.96% while it is 92.94% in the generalized one. The average values of personalized specificity and sensitivity are 99.69% and 93.91% while the generalized classifier gives 95.38% and 87.4%.
健康参数,如心律,血压,血氧饱和度水平可以测量光容积脉搏波(PPG)信号。智能手机相机传感器的出现使得从智能手机中提取PPG信号成为可能。在运动和噪声伪影(MNA)下,PPG信号很弱,可能会产生不可靠的心率测量。智能手机PPG信号更容易发生MNA,因为它们不是为临床应用而设计的。PPG信号被称为生物特征信号,因为它们对每个个体都有独特的行为。然而,在以前的MNA检测研究中,没有考虑到这种个性化特征。本文提出了一种基于概率神经网络的个性化MNA检测方法。我们的个性化方法在准确性、特异性和敏感性方面对25名志愿者进行了评估,并与广义方法进行了比较。个性化方法的平均准确率为97.96%,广义方法的平均准确率为92.94%。个性化特异性和敏感性的平均值分别为99.69%和93.91%,广义分类器的平均值分别为95.38%和87.4%。
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引用次数: 1
Nighttime Sleep Duration Prediction for Inpatient Rehabilitation Using Similar Actigraphy Sequences 利用相似活动描记序列预测住院康复患者夜间睡眠时间
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962839
Allison Fellger, Gina Sprint, Alexa Andrews, D. Weeks, Elena Crooks
Actigraphs are wearable sensors used to collect activity and sleep time series data from healthy and unhealthy populations. Unhealthy populations, such as individuals undergoing inpatient rehabilitation, typically exhibit abnormal daytime physical activity and nighttime sleeping patterns due to their injury and drastic changes in their activities of daily living. Consequently, Actigraph data collected from patients attending inpatient rehabilitation are often noisy and can be difficult to reliably draw conclusions from. In this paper, we apply machine learning to analyze such highly variable Actigraph data. We collected 24-hour, minute-by-minute Actigraph data from 17 patients receiving inpatient therapy post-stroke or post-traumatic brain injury. Our approach utilizes similarities among historical sequences of data to train machine learning algorithms to predict nighttime sleep duration. By tuning parameters related to our regression algorithm, we obtained a normalized root mean square error of 14.40%. Our approach is suitable for point of care and remote monitoring to detect changes in sleep for individuals recovering from stroke and traumatic brain injuries.
活动记录仪是一种可穿戴传感器,用于收集健康和不健康人群的活动和睡眠时间序列数据。不健康人群,如接受住院康复治疗的个人,由于受伤和日常生活活动的剧烈变化,通常表现出不正常的白天身体活动和夜间睡眠模式。因此,从住院康复患者那里收集的活动记录仪数据通常是嘈杂的,很难可靠地得出结论。在本文中,我们应用机器学习来分析这种高度可变的Actigraph数据。我们收集了17例中风或创伤性脑损伤后接受住院治疗的患者24小时、每分钟的活动图数据。我们的方法利用历史数据序列之间的相似性来训练机器学习算法来预测夜间睡眠持续时间。通过对回归算法相关参数进行调优,得到归一化均方根误差为14.40%。我们的方法适用于点护理和远程监测,以检测从中风和创伤性脑损伤中恢复的个体的睡眠变化。
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引用次数: 1
Portable and Wearable Device for Microwave Head Diagnostic Systems 用于微波头诊断系统的便携式和可穿戴设备
Pub Date : 2019-11-01 DOI: 10.1109/HI-POCT45284.2019.8962890
Imran M. Saied, Syed Ali Akbar Hussainy
In recent years, there have been considerable developments in smart wearable devices and unobtrusive monitoring systems that can be used in detecting and monitoring a patient’s health. However, these technological advances have not been implemented for head diagnostics, where the majority of hospitals still relying on MRI or CT scans which are bulky and expensive. In this paper, a wearable and portable device is presented that can be used for microwave head diagnostic systems. The device contains 8 RF sensors that are placed in the inner lining of a hat. The sensors are then connected to a miniaturized vector network analyzer (VNA) that generates and receives signals from the sensors. The signals from the VNA can be captured and processed in a laptop, or it can transfer the data via a Bluetooth module to a mobile device that can process the data in an app. Experiments were performed on a brain phantom to verify the performance of the device. Objects of different sizes were placed in the phantom and measured to represent diseases such as stroke and tumour. Results from the experiments showed that the deice was capable of detecting different levels of diseases in the brain. As a result, the proposed device provides a promising technique for non-invasive head diagnostics that is wearable, portable, and inexpensive.
近年来,智能可穿戴设备和不显眼的监测系统有了长足的发展,可用于检测和监测患者的健康状况。然而,这些技术进步并没有应用于头部诊断,大多数医院仍然依赖于体积庞大且昂贵的MRI或CT扫描。本文提出了一种可用于微波头诊断系统的可穿戴便携式设备。该设备包含8个射频传感器,放置在帽子的内衬中。然后将传感器连接到一个小型矢量网络分析仪(VNA),该分析仪产生和接收来自传感器的信号。来自VNA的信号可以在笔记本电脑中捕获和处理,也可以通过蓝牙模块将数据传输到可以在应用程序中处理数据的移动设备上。为了验证设备的性能,在大脑幻影上进行了实验。不同大小的物体被放置在幻影中,并测量它们代表的疾病,如中风和肿瘤。实验结果表明,该设备能够检测出大脑中不同程度的疾病。因此,所提出的设备为非侵入性头部诊断提供了一种有前途的技术,该技术可穿戴、便携且价格低廉。
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引用次数: 1
期刊
2019 IEEE Healthcare Innovations and Point of Care Technologies, (HI-POCT)
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