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Concerns and Challenges of Cloud Platforms for Bioinformatics 生物信息学云平台的关注与挑战
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2255-3.CH040
N. Dessì, B. Pes
Bioinformatics traditionally concerns applying computational approaches for the management and the exploitation of large volumes of biomedical data that continues to expand in size and in distribution. Although the application of cloud computing in biomedical areas is still preliminary, an increasing number of biomedical applications rely on the Cloud for processing large datasets. This chapter investigates the extent to which cloud technology offers a viable platform for developing and deploying applications that support users in searching and integrating information offered by bioinformatics resources. The chapter outlines the basic features that such computing applications should exhibit and the challenging issues they deal with. The architecture and the functionality of the cloud-based environments are presented to stress how cloud platforms could offer added-value service components and flexibility that make their adoption attractive for bioinformatics.
生物信息学传统上关注应用计算方法来管理和开发大量的生物医学数据,这些数据在规模和分布上都在不断扩大。尽管云计算在生物医学领域的应用仍处于初级阶段,但越来越多的生物医学应用依赖于云来处理大型数据集。本章调查了云技术在多大程度上为开发和部署支持用户搜索和整合生物信息学资源提供的信息的应用程序提供了一个可行的平台。本章概述了这些计算应用程序应该展示的基本特征以及它们处理的具有挑战性的问题。本文介绍了基于云的环境的架构和功能,以强调云平台如何提供增值服务组件和灵活性,从而使其对生物信息学的采用具有吸引力。
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引用次数: 0
Building Gene Networks by Analyzing Gene Expression Profiles 通过分析基因表达谱构建基因网络
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2255-3.CH039
C. Gallo
The possible applications of modeling and simulation in the field of bioinformatics are very extensive, ranging from understanding basic metabolic paths to exploring genetic variability. Experimental results carried out with DNA microarrays allow researchers to measure expression levels for thousands of genes simultaneously, across different conditions and over time. A key step in the analysis of gene expression data is the detection of groups of genes that manifest similar expression patterns. In this chapter, the authors examine various methods for analyzing gene expression data, addressing the important topics of (1) selecting the most differentially expressed genes, (2) grouping them by means of their relationships, and (3) classifying samples based on gene expressions.
建模和模拟在生物信息学领域的可能应用非常广泛,从了解基本的代谢途径到探索遗传变异。用DNA微阵列进行的实验结果使研究人员能够在不同的条件和时间内同时测量数千个基因的表达水平。基因表达数据分析的关键步骤是检测具有相似表达模式的基因组。在本章中,作者研究了分析基因表达数据的各种方法,解决了(1)选择差异表达最多的基因,(2)通过它们的关系对它们进行分组,以及(3)基于基因表达对样本进行分类的重要主题。
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引用次数: 2
Integrating Evidence-Based Practice in Athletic Training Though Online Learning 通过在线学习整合运动训练的循证实践
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2255-3.CH505
B. Vorndran, M. D'Abundo
Evidence-based practice (EBP) involves a healthcare professional using his or her own knowledge, the current research published, and the needs of the patient to make the best clinical decision. This has been a hot topic in many different branches of healthcare and recently athletic trainers have begun to embrace its importance. In December of 2015, athletic trainers (ATs) will need to have completed 10 of their 50 continuing education units (CEUs) in EBP to maintain certification. While ATs recognize the significance of implementing EBP into clinical decision making, there are many barriers slowing the change. This chapter includes information about how EBP is currently being used by athletic training clinicians and educators, the barriers ATs perceive to using EBP, the importance of using EBP, and managing the transition needed to successfully adopt the use of EBP. Online learning will be reviewed as the primary method of diffusing EBP into the profession of athletic training.
基于证据的实践(EBP)涉及医疗保健专业人员使用他或她自己的知识、当前发表的研究和患者的需求来做出最佳的临床决策。这在医疗保健的许多不同分支中一直是一个热门话题,最近运动教练已经开始接受它的重要性。2015年12月,运动教练(at)需要完成EBP的50个继续教育单元(ceu)中的10个才能保持认证。虽然ATs认识到在临床决策中实施EBP的重要性,但仍有许多障碍减缓了这一变化。这一章包括关于目前运动训练临床医生和教育工作者如何使用EBP的信息,运动员认为使用EBP的障碍,使用EBP的重要性,以及成功采用EBP所需的过渡管理。在线学习将被视为将EBP传播到运动训练专业的主要方法。
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引用次数: 3
A Validation Study of Rehabilitation Exercise Monitoring Using Kinect 使用Kinect进行康复运动监测的验证研究
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2255-3.CH517
Wenbing Zhao, D. Espy, Ann Reinthal
In this chapter, the authors present their work on a validation study of using Microsoft Kinect to monitor rehabilitation exercises. Differing from other validation efforts, the authors focus on a system-level assessment instead of the joint-level comparison with reference motion capture systems. They assess the feasibility of using Kinect by examining the enforceability of a set of correctness rules defined for each exercise, which are invariances of each exercise and hence independent from the coordinate system used. This method is more advantageous in that (1) it does not require coordinate system transformation between those of the reference motion capture system and of the Kinect-based system, (2) it does not require an exact match of the Kinect joints and the corresponding external marker placements or derived joint centers often used in reference motion capture systems, and (3) the correctness rules and their mapping for Kinect motion data analysis developed in this study are readily implementable for a real motion monitoring system for physical therapy.
在本章中,作者介绍了他们在使用微软Kinect监测康复练习的验证研究上的工作。与其他验证工作不同,作者专注于系统级评估,而不是与参考运动捕捉系统的联合级比较。他们通过检查为每个练习定义的一组正确性规则的可执行性来评估使用Kinect的可行性,这些规则是每个练习的不变性,因此独立于所使用的坐标系。该方法的优势在于:(1)它不需要参考动作捕捉系统和基于Kinect的系统之间的坐标系转换;(2)它不需要Kinect关节与参考动作捕捉系统中经常使用的相应的外部标记位置或派生关节中心精确匹配。(3)本研究开发的Kinect运动数据分析的正确性规则及其映射很容易用于物理治疗的真实运动监测系统。
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引用次数: 3
Information Systems and Technology Projects in Healthcare Organizations 医疗机构中的信息系统和技术项目
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-7489-7.ch017
J. Gomes, M. Romão
Healthcare organizations must improve their business practices and internal procedures in order to meet the increasing demands of health professionals and the public in general for better information. Hospitals have adopted a patient-centered care approach and have invested massively in information systems and technology (IS/IT), in the hope that these investments will improve medical care and that they will meet patient demands. From the point of view of public service, the focus of healthcare system is the patient, and therefore any intervention should be based on their needs and expectations. It has become more and more important that investments in information systems and technology (IS/IT) support not only short-term objectives, but also long-term benefits, in order to provide a sustainable service for organizations, professionals, and users. The main objective of this research is to study how organizational maturity, enhanced by IS/IT investments and project management best practices, leads to successful projects in healthcare organizations.
医疗保健组织必须改进其业务实践和内部程序,以满足医疗保健专业人员和公众对更好的信息日益增长的需求。医院采取了以患者为中心的护理方法,并在信息系统和技术(IS/IT)方面进行了大量投资,希望这些投资将改善医疗保健,并满足患者的需求。从公共服务的角度来看,医疗系统的焦点是病人,因此任何干预都应该基于病人的需求和期望。信息系统和技术(IS/ It)的投资不仅支持短期目标,而且支持长期利益,以便为组织、专业人员和用户提供可持续的服务,这一点变得越来越重要。本研究的主要目标是研究通过is /IT投资和项目管理最佳实践增强的组织成熟度如何在医疗保健组织中导致成功的项目。
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引用次数: 0
Using Technology to Reduce a Healthcare Disparity 利用技术减少医疗保健差距
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2255-3.CH323
N. Wickramasinghe
Superior healthcare delivery requires good communication. For people who have English as a second language, this is particularly challenging. Given the advances in technology, most especially with Web 2.0 and cloud computing, the following proffers a technology-mediated solution to address communication barriers that result when delivering healthcare to non-English speakers or limited-proficiency English-speaking patients. This solution serves to reduce healthcare disparities, satisfy meaningful use requirements, and provide superior healthcare delivery that is efficient, effective, and efficacious.
优质的医疗服务需要良好的沟通。对于以英语为第二语言的人来说,这尤其具有挑战性。考虑到技术的进步,尤其是Web 2.0和云计算的发展,下面提供了一种技术中介解决方案,用于解决在向非英语使用者或英语水平有限的患者提供医疗保健服务时出现的沟通障碍。此解决方案用于减少医疗保健差异,满足有意义的使用需求,并提供高效、有效和高效的卓越医疗保健交付。
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引用次数: 0
Bioinspired Solutions for MEMS Tribology MEMS摩擦学的仿生解决方案
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2255-3.CH038
R. A. Singh, S. Jayalakshmi
Micro-electro mechanical systems (MEMS) are miniaturized devices that operate at a small scale. Actuators-based MEMS have not been commercially realized yet, owing to the manifestation of high surface forces such as adhesion and friction between their moving elements. In recent years, inspiration from “Lotus Effect” has opened a new direction in the field of micro/nano-tribology to manipulate/control surface forces at small scale. The underlying principle discovered from the super-hydrophobic nature of the leaves of water-repellent plants has led to the design and development of various biomimetic tribological surfaces that exhibit remarkable reduction in surface forces under tribological contact. This chapter presents the tribological issues in MEMS devices, examples of conventional solutions for the tribological issues, and unique bioinspired solutions that have great capability to mitigate surface forces at micro/nano-scales.
微机电系统(MEMS)是一种在小范围内运行的小型化设备。基于致动器的MEMS尚未商业化实现,由于其运动元件之间的粘附和摩擦等高表面力的表现。近年来,受到“莲花效应”的启发,在微/纳米摩擦学领域开辟了一个新的方向,即在小尺度上操纵/控制表面力。从疏水植物叶片的超疏水性中发现的基本原理导致了各种仿生摩擦学表面的设计和开发,这些表面在摩擦学接触下表现出显着的表面力减少。本章介绍了MEMS器件中的摩擦学问题,摩擦学问题的传统解决方案的示例,以及独特的生物启发解决方案,这些解决方案具有在微/纳米尺度上减轻表面力的强大能力。
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引用次数: 0
User Resistance to Health Information Technology 用户对健康信息技术的抵制
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2255-3.CH331
Madison N. Ngafeeson
The use of information technology (IT) in healthcare to improve outcomes is now a global phenomenon. If effectively implemented and efficiently leveraged, these technologies will greatly lower healthcare costs, improve safety, and elevate the quality of health. Nevertheless, health IT implementation and adoption continues to meet challenges. Reports show that physicians, nurses, and other healthcare professionals continue to resist health IT. Researchers have proposed models to explain this notion, and till date, there still is a lack of an overarching paradigm to view the concept. Resistance is a complex phenomenon that defies simple explanation and analysis. It requires well-accepted theories or paradigms encompassing the full range of variables associated with it. Understanding and mitigating user resistance is a great step toward improving sector-wide adoption. In this chapter, the authors survey extant theories of resistance and provide a paradigmatic lens for leveraging this knowledge to practical solutions in health IT adoption.
在医疗保健中使用信息技术(IT)来改善结果现在是一种全球现象。如果得到有效实施和有效利用,这些技术将大大降低医疗保健成本,改善安全性并提高健康质量。然而,卫生信息技术的实施和采用继续面临挑战。报告显示,医生、护士和其他医疗保健专业人员继续抵制医疗IT。研究人员提出了一些模型来解释这一概念,但到目前为止,仍然缺乏一个总体的范式来看待这一概念。抵抗是一种复杂的现象,无法简单地解释和分析。它需要广泛接受的理论或范式,包括与之相关的所有变量。理解和减轻用户的阻力是朝着提高整个行业的采用迈出的重要一步。在本章中,作者调查了现有的抵抗理论,并提供了一个范例镜头,以利用这些知识在卫生IT采用的实际解决方案。
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引用次数: 1
Electronic Health Record (EHR) Diffusion and an Examination of Physician Resistance 电子健康记录(EHR)的传播和医师阻力的检查
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-2255-3.CH319
Kristen MacIver, Madison N. Ngafeeson
Since the enactment of the United States Health Information Technology for Economic and Clinical Health (HITECH) Act in 2009, there has been substantial progress in the diffusion of electronic health record (EHR) systems in medical clinics throughout the United States. Many physicians, however, continue to resist adopting EHR technology despite several accepted, long-term benefits and available government-sponsored financial incentives. The objective of this chapter is to provide insight into the question as to why physicians are resistant to adopting EHR technology. This chapter details several of the benefits of EHR systems and uses a systematic review of literature to critically analyze and detail the most common perceived physician barriers to the adoption of EHRs. With the awareness of the major physician barriers to the adoption of EHR technology, stakeholders and policymakers can address barriers and pursue actions to mitigate or reduce physician resistance to achieve nationwide diffusion targets and pursue initiatives to digitize all patient records.
自2009年颁布《美国卫生信息技术促进经济和临床健康(HITECH)法案》以来,电子健康记录(EHR)系统在美国各地医疗诊所的推广取得了实质性进展。然而,尽管有一些公认的、长期的好处和政府资助的财政激励措施,许多医生仍然抵制采用电子病历技术。本章的目的是提供深入了解的问题,为什么医生是抵制采用电子病历技术。本章详细介绍了电子病历系统的几个好处,并对文献进行了系统的回顾,以批判性地分析和详细介绍了采用电子病历的最常见的医生障碍。随着医生对采用电子病历技术的主要障碍的认识,利益相关者和政策制定者可以解决障碍,采取行动减轻或减少医生的阻力,以实现全国推广目标,并采取行动将所有患者记录数字化。
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引用次数: 4
Pervasive Mobile Health 普及流动医疗
Pub Date : 1900-01-01 DOI: 10.4018/978-1-5225-7489-7.CH034
M. Anshari, M. Almunawar
Pervasive mobile health is mobile health that provides healthcare services that are accessible regardless of time and place where patients can continuously be connected through their smart mobile devices. It offers healthcare providers a more comprehensive perspective of patients' conditions and thus aids in achieving complex healthcare goal(s) such as building lasting relationships with patients. The service can be further extended to accommodate customers' participation in health and healthcare processes to improve healthcare services by extending roles of patients. The advancement of the web technologies, especially social networks, push e-health to embrace mobile devices (m-health) and personalize customer-centric services with a possibility to extend and improve services by enabling active participation of patients, patients' families, and the community at large in healthcare processes and personal health decision making. This chapter addresses some important concepts of m-health, challenges, future trends, and some related terminologies to provide a holistic view of m-health.
普适移动医疗是一种移动医疗,它提供的医疗服务无论何时何地都可以访问,患者可以通过其智能移动设备持续连接。它为医疗保健提供者提供了更全面的患者状况视角,从而有助于实现复杂的医疗保健目标,例如与患者建立持久的关系。该服务可以进一步扩展,以适应客户参与健康和医疗保健流程,从而通过扩展患者的角色来改善医疗保健服务。网络技术(尤其是社交网络)的进步,推动电子医疗采用移动设备(移动医疗)和个性化以客户为中心的服务,使患者、患者家属和整个社区能够积极参与医疗保健流程和个人健康决策,从而有可能扩展和改进服务。本章阐述了移动健康的一些重要概念、挑战、未来趋势和一些相关术语,以提供移动健康的整体观点。
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引用次数: 1
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Advanced Methodologies and Technologies in Medicine and Healthcare
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