ACS Synthetic Biology最新文献

{"title":"Dysglycemia and liver lipid content influence the link between insulin resistance and liver mitochondrial function in obesity – Author’s reply","authors":"Sabine Kahl, Michael Roden","doi":"10.1016/j.jhep.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.11.003","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial suppport</h2>The research of the authors is supported in part by grants from the German Federal Ministry of Health (BMG), the Ministry of Culture and Science of the State North Rhine Westphalia (MKW NRW) to DDZ, and the German Federal Ministry of Education and Research (BMBF) and the MKW NRW to German Center for Diabetes Research (DZD e. V.). The research of M.R. is supported by grants from the European Community (HORIZON-HLTH-2022-STAYHLTH-02-01: Panel A) to the INTERCEPT-T2D consortium, the German Science</section></section><section><section><h2>Author contributions</h2>S.K. drafted the manuscript. S.K. and M.R. revised and approve the final version of the manuscript. M.R. is the guarantor of this work, with full access to all data and analyses related to the content of this article.</section></section><section><section><h2>ClinTrials.gov identifier</h2>NCT01477957We thank Xiyin Yang and Qiang Hu for their interest in our article [1], which investigated the association of whole-body insulin sensitivity and hepatic OXPHOS capacity in people with obesity grade 3. We would like to take the opportunity to address their comments on our study.First, the prospective BARIA-DDZ study was designed to assess metabolic changes with one focus on different features of hepatic mitochondrial function in people with obesity. For this purpose, we developed a</section></section><section><section><h2>Declaration of Competing Interest</h2>M.R. received lecture fees or served on advisory boards for AstraZeneca, Echosens, Eli Lilly, Madrigal, Merck-MSD, Novo Nordisk and Target RWE and performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk and Nutricia/Danone to the German Diabetes Center (DDZ). No conflicts of interest, financial or otherwise, are declared by the other authors.</section></section>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"18 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic plasma exchange in acute liver failure: Challenges in patient selection and optimal timing of intervention","authors":"Bikrant Bihari Lal, Seema Alam","doi":"10.1016/j.jhep.2024.10.036","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.036","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Author’s contribution</h2>BBL prepared the first draft. SA critically reviewed and approved the final manuscript.</section></section><section><section><h2>Financial disclosure</h2>None</section></section><section><section><h2>Declaration of Competing Interest</h2>Bikrant Bihari Lal and Seema Alam declare no financial or non-financial conflict of interest.</section></section>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"16 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142597854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stealthy neural recorder for the study of behaviour in primates","authors":"Saehyuck Oh, Janghwan Jekal, Jinyoung Won, Kyung Seob Lim, Chang-Yeop Jeon, Junghyung Park, Hyeon-Gu Yeo, Yu Gyeong Kim, Young Hee Lee, Leslie Jaesun Ha, Han Hee Jung, Junwoo Yea, Hyeokjun Lee, Jeongdae Ha, Jinmo Kim, Doyoung Lee, Soojeong Song, Jieun Son, Tae Sang Yu, Jungmin Lee, Sanghoon Lee, Jaehong Lee, Bong Hoon Kim, Ji-Woong Choi, Jong-Cheol Rah, Young Min Song, Jae-Woong Jeong, Hyung Jin Choi, Sheng Xu, Youngjeon Lee, Kyung-In Jang","doi":"10.1038/s41551-024-01280-w","DOIUrl":"https://doi.org/10.1038/s41551-024-01280-w","url":null,"abstract":"<p>By monitoring brain neural signals, neural recorders allow for the study of neurological mechanisms underlying specific behavioural and cognitive states. However, the large brain volumes of non-human primates and their extensive range of uncontrolled movements and inherent wildness make it difficult to carry out covert and long-term recording and analysis of deep-brain neural signals. Here we report the development and performance of a stealthy neural recorder for the study of naturalistic behaviours in non-human primates. The neural recorder includes a fully implantable wireless and battery-free module for the recording of local field potentials and accelerometry data in real time, a flexible 32-electrode neural probe with a resorbable insertion shuttle, and a repeater coil-based wireless-power-transfer system operating at the body scale. We used the device to record neurobehavioural data for over 1 month in a freely moving monkey and leveraged the recorded data to train an artificial intelligence model for the classification of the animals’ eating behaviours.</p>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"95 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142597609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Immune checkpoint inhibitor therapy for functional cure of hepatitis B in cancer patients: a promising strategy?” and “Hepatocellular Carcinoma Patients as an Ideal Study Population for Immune Checkpoint Inhibitors in Hepatitis B”","authors":"Hsien-Chen Mon, Yi-Hsiang Huang","doi":"10.1016/j.jhep.2024.10.045","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.045","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial disclosure funding</h2>No financial support was received for this letter.</section></section><section><section><h2>Funding funding</h2>None</section></section><section><section><h2>Conflict-of-interest statement COI</h2>The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</section></section><section><section><h2>Author contributions author-disclosure</h2>HCM: manuscript drafting; YHH: critical expert review and revision of the manuscript.</section></section><section><section><h2>Acknowledgements</h2>There are no additional acknowledgements.</section></section>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"29 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Reassessing the causal association between frailty and chronic liver disease: Evidence from genetic analyses”","authors":"Qi Zhong, Hao-Wen Chen, Shun Zhang, Ji-Yuan Zhou, Xian-Bo Wu","doi":"10.1016/j.jhep.2024.10.034","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.034","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Data availability statement</h2>GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (<span><span>https://gwas.mrcieu.ac.uk/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (<span><span>https://r11.finngen.fi/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>).</section></section><section><section><h2>Authors’ contributions</h2>QZ, H-WC, and SZ drafted the manuscript and performed the main MR analyses. X-BW and J-YZ revised the manuscript. All authors reviewed and approved the final manuscript.</section></section><section><section><h2>Financial support</h2>This study was supported by the National Natural Science Foundation of China [grant numbers 82173607, 82173619], and the Guangdong Basic and Applied Basic Research Foundation [grant numbers 2021A1515011684, 2024A1515011969]. The funders had no role in study design, data collection or analysis, data interpretation, manuscript writing, or decision to submit the paper for publication.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors of this study declare that they do not have any conflict of interest.</section></section><section><section><h2>Acknowledgements</h2>GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (<span><span>https://gwas.mrcieu.ac.uk/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (<span><span>https://r11.finngen.fi/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>).</section></section>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"61 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: “From mice to humans: Unravelling the genetic levers of NASH” [J Hepatol (2020) 749-751]","authors":"Wajahat Zafar Mehal","doi":"10.1016/j.jhep.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.002","url":null,"abstract":"It has come to our attention that the following text should have been included in the ‘Financial support’ section of this article: “Dr. Mehal has an appointment at the West Haven VA Medical Center and this work was supported by a US Department of Veterans Office of Research &amp; Development with grant BX003259-05A1”. We apologise for any inconvenience caused.","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"37 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Assessment of Protein Engineering (CAPE): A Student Challenge on the Cloud","authors":"Lihao Fu,&nbsp;Yuan Gao,&nbsp;Yongcan Chen,&nbsp;Yanjing Wang,&nbsp;Xiaoting Fang,&nbsp;Shujun Tian,&nbsp;Hao Dong,&nbsp;Yijian Zhang,&nbsp;Zichuan Chen,&nbsp;Zechen Wang,&nbsp;Shantong Hu,&nbsp;Xiao Yi* and Tong Si*,&nbsp;","doi":"10.1021/acssynbio.4c0058810.1021/acssynbio.4c00588","DOIUrl":"https://doi.org/10.1021/acssynbio.4c00588https://doi.org/10.1021/acssynbio.4c00588","url":null,"abstract":"<p >The success of AlphaFold in protein structure prediction highlights the power of data-driven approaches in scientific research. However, developing machine learning models to design and engineer proteins with desirable functions is hampered by limited access to high-quality data sets and experimental feedback. The Critical Assessment of Protein Engineering (CAPE) challenge addresses these issues through a student-focused competition, utilizing cloud computing and biofoundries to lower barriers to entry. CAPE serves as an open platform for community learning, where mutant data sets and design algorithms from past contestants help improve overall performance in subsequent rounds. Through two competition rounds, student participants collectively designed &gt;1500 new mutant sequences, with the best-performing variants exhibiting catalytic activity up to 5-fold higher than the wild-type parent. We envision CAPE as a collaborative platform to engage young researchers and promote computational protein engineering.</p>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"13 11","pages":"3782–3787 3782–3787"},"PeriodicalIF":3.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acssynbio.4c00588","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Methodology and Data Integrity in Mendelian Randomization: Insights from Air Pollution and MASLD Research","authors":"Junhao Chen, Haifeng Wang, Shi Fu","doi":"10.1016/j.jhep.2024.10.040","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.040","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors’ contributions</h2>Junhao Chen: conceptualization and manuscript draft. Haifeng Wang: supporting role in revision for important intellectual content. Shi Fu: critical revision for important intellectual content, final approval.</section></section><section><section><h2>Financial support</h2>None</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors of this study declare that they do not have any conflict of interest.</section></section>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"304 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Prediction of HBsAg loss after cessation of entecavir therapy”","authors":"Rex Wan-Hin Hui, Lung-Yi Mak, Man-Fung Yuen","doi":"10.1016/j.jhep.2024.10.041","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.041","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>AUTHOR CONTRIBUTIONS</h2>RWH Hui was involved in manuscript design and drafting of manuscript. LY Mak was involved in critical revision of manuscript. MF Yuen was involved in critical revision of manuscript and overall study supervision. The authors declare that they have participated in the preparation of the manuscript and have seen and approved the final version.</section></section><section><section><h2>DISCLOSURES/ CONFLICT OF INTEREST STATEMENT</h2>MF Yuen is an advisory board member and/or received research funding from AbbVie, Arbutus Biopharma, Assembly Biosciences, Bristol Myer Squibb, Dicerna Pharmaceuticals, GlaxoSmithKline, Gilead Sciences, Janssen, Merck Sharp and Dohme, Clear B Therapeutics, Springbank Pharmaceuticals; and received research funding from Arrowhead Pharmaceuticals, Fujirebio Incorporation and Sysmex Corporation. The remaining authors have no conflict of interests.</section></section><section><section><h2>DATA AVAILABILITY STATEMENT</h2>The data from this study is available from the corresponding author upon reasonable request.</section></section><section><section><h2>Funding</h2>Innovative Research Fund of the State Key Laboratory of Liver Research, The University of Hong Kong (ref. no.: SKLLR/IRF/2018/07) and the S. K. Yee Medical Foundation Grant (ref. no.: 2141213). The funders had no involvement in study design, data collection/ analysis/ interpretation, writing of the manuscript or decision to submit the article for publication.</section></section>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"61 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma exchange in Acute liver failure: The jury is still out!","authors":"Sagnik Biswas, Shekhar Swaroop","doi":"10.1016/j.jhep.2024.10.037","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.037","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial disclosures funding</h2>None</section></section><section><section><h2>Conflicts of interest COI</h2>The authors declare no conflicts of interest</section></section><section><section><h2>Authors contributions author-disclosure</h2>SB and SS wrote the initial draft. S revised the paper. All authors approved the final manuscript.</section></section>","PeriodicalId":26,"journal":{"name":"ACS Synthetic Biology","volume":"45 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}