Background: The rate of treatment adherence in patients with schizophrenia is lower than average, and they have insufficient insight in this regard. Objectives: The present study was designed to assess the effectiveness of group cognitive behavioral therapy (GCBT) in the improvement of insight and treatment adherence in schizophrenic patients. Methods: In this randomized controlled trial, accomplished in Shiraz Psychiatric Hospital, Shiraz, Iran, from October 2021 to January 2022, 22 eligible participants were assigned to either intervention, therapist’s attention placebo, and control groups via simple randomization. In the intervention group, a treatment program was performed in seven 90-minute sessions based on a treatment protocol adapted from Robert Paul Lieberman’s 16-session community return program. The therapist’s placebo group also watched documentaries for seven sessions. The control group received only their usual treatments, which included a visit to a psychiatrist. The data were gathered using the Insight and Treatment Attitudes Questionnaire and the Medication Adherence Rating Scale at three different time points. Results: At baseline, the mean scores of insight and medication adherence were not significantly different between all the groups. After the intervention, the results showed significant differences in insight levels (P = 0.001) and medication adherence (P = 0.003). Three months after the intervention, the results showed significant differences in insight levels and medication adherence (P = 0.001). The differences in the mean scores of insight levels and medication adherence in post-intervention and 3-month follow-up were only significant in the intervention group (P = 0.001). Conclusions: Based on the evidence from this study, GCBT is an effective treatment for improving insight and medication adherence in schizophrenic patients. Therefore, it is necessary to pay attention to the use of GCBT to increase compliance with drug treatment.
{"title":"Effectiveness of Group Cognitive Behavioral Therapy in Insight and Treatment Adherence in Schizophrenic Patients: A Randomized Controlled Trial","authors":"Samad Fereidooni, Leila Razeghian, Nilofar Fateh","doi":"10.5812/jjcdc-135541","DOIUrl":"https://doi.org/10.5812/jjcdc-135541","url":null,"abstract":"Background: The rate of treatment adherence in patients with schizophrenia is lower than average, and they have insufficient insight in this regard. Objectives: The present study was designed to assess the effectiveness of group cognitive behavioral therapy (GCBT) in the improvement of insight and treatment adherence in schizophrenic patients. Methods: In this randomized controlled trial, accomplished in Shiraz Psychiatric Hospital, Shiraz, Iran, from October 2021 to January 2022, 22 eligible participants were assigned to either intervention, therapist’s attention placebo, and control groups via simple randomization. In the intervention group, a treatment program was performed in seven 90-minute sessions based on a treatment protocol adapted from Robert Paul Lieberman’s 16-session community return program. The therapist’s placebo group also watched documentaries for seven sessions. The control group received only their usual treatments, which included a visit to a psychiatrist. The data were gathered using the Insight and Treatment Attitudes Questionnaire and the Medication Adherence Rating Scale at three different time points. Results: At baseline, the mean scores of insight and medication adherence were not significantly different between all the groups. After the intervention, the results showed significant differences in insight levels (P = 0.001) and medication adherence (P = 0.003). Three months after the intervention, the results showed significant differences in insight levels and medication adherence (P = 0.001). The differences in the mean scores of insight levels and medication adherence in post-intervention and 3-month follow-up were only significant in the intervention group (P = 0.001). Conclusions: Based on the evidence from this study, GCBT is an effective treatment for improving insight and medication adherence in schizophrenic patients. Therefore, it is necessary to pay attention to the use of GCBT to increase compliance with drug treatment.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"23 23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128438299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farzad Shahini Shamsabadi, Ali Hassanpour Dehkordi, Shahriyar Salehi Tali, Hadi Raeisi Shahraki
Background: Useful communication between patients and nurses and improvement of the quality of care occur following partnership care, resulting in an improvement in the general condition of patients. Objectives: Regarding the cancer patients’ need for education and the important role of nurses in education and care, the present study aimed to investigate the effect of nursing interventions based on the partnership care model on the life expectancy of cancer patients in teaching hospitals of Shahrekord. Methods: The present quasi-experimental study was conducted on 60 cancer patients in Shahrekord educational hospitals in 2021. The subjects of this study were first selected according to inclusion criteria and then randomly divided into the intervention and control groups by random allocation software. The educational intervention based on the partnership care model was carried out in four individual stages, including the creation of motivation, preparation, involvement, and evaluation. The researcher used demographic information questionnaires and Schneider’s Life Expectancy Questionnaire as data collection instruments. Using SPSS 24 software and independent t-test, chi-square test, and analysis of variance, the mean scores before, 48 hours after intervention, and two months after intervention were compared. Results: There was no significant difference between the two groups in terms of mean life expectancy scores before the intervention (P > 0.82), but the scores immediately and two months after the intervention showed a statistically significant difference between the control and intervention groups (P < 0.001). Conclusions: Implementing the educational intervention based on the partnership care model can increase the life expectancy of cancer patients. Due to this program’s effectiveness, low cost, and safety, hospital managers are recommended to use this program to promote health and enhance the patient’s knowledge.
{"title":"Effect of Nursing Interventions Based on Partnership Care Model on Life Expectancy in Cancer Patients in Shahrekord Teaching Hospitals","authors":"Farzad Shahini Shamsabadi, Ali Hassanpour Dehkordi, Shahriyar Salehi Tali, Hadi Raeisi Shahraki","doi":"10.5812/jjcdc-132643","DOIUrl":"https://doi.org/10.5812/jjcdc-132643","url":null,"abstract":"Background: Useful communication between patients and nurses and improvement of the quality of care occur following partnership care, resulting in an improvement in the general condition of patients. Objectives: Regarding the cancer patients’ need for education and the important role of nurses in education and care, the present study aimed to investigate the effect of nursing interventions based on the partnership care model on the life expectancy of cancer patients in teaching hospitals of Shahrekord. Methods: The present quasi-experimental study was conducted on 60 cancer patients in Shahrekord educational hospitals in 2021. The subjects of this study were first selected according to inclusion criteria and then randomly divided into the intervention and control groups by random allocation software. The educational intervention based on the partnership care model was carried out in four individual stages, including the creation of motivation, preparation, involvement, and evaluation. The researcher used demographic information questionnaires and Schneider’s Life Expectancy Questionnaire as data collection instruments. Using SPSS 24 software and independent t-test, chi-square test, and analysis of variance, the mean scores before, 48 hours after intervention, and two months after intervention were compared. Results: There was no significant difference between the two groups in terms of mean life expectancy scores before the intervention (P > 0.82), but the scores immediately and two months after the intervention showed a statistically significant difference between the control and intervention groups (P < 0.001). Conclusions: Implementing the educational intervention based on the partnership care model can increase the life expectancy of cancer patients. Due to this program’s effectiveness, low cost, and safety, hospital managers are recommended to use this program to promote health and enhance the patient’s knowledge.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"237 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121036955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Students’ academic performance and university output can be affected by mental health. Objectives: The present study aimed to investigate the prevalence of depression, anxiety, stress, and worry and its relationship with the academic performance of medical students during the coronavirus disease 2019 (COVID-19) pandemic in Iran. Methods: In this descriptive-correlational research, 261 medical students participated in Iran. The standard Depression, Anxiety, and Stress Scale (DASS-21) and the Pennsylvania Standard Worry Questionnaire (PSWQ) were used to collect data. Similarly, students’ grade point averages (GPAs) were considered an indicator of their academic performance. The statistical analysis was carried out using IBM’s Statistical Package for Social Sciences (SPSS) software version 25.0. The level of statistical significance was reported at P
{"title":"Investigating the Prevalence of Depression, Anxiety, Stress, and Worry, and its Relationship with the Academic Performance of Medical Students During the Coronavirus Disease 2019 Pandemic in Iran","authors":"A. Gilavand, Behnoosh Khoshouie, S. Mohamadpour","doi":"10.5812/jjcdc-137714","DOIUrl":"https://doi.org/10.5812/jjcdc-137714","url":null,"abstract":"Background: Students’ academic performance and university output can be affected by mental health. Objectives: The present study aimed to investigate the prevalence of depression, anxiety, stress, and worry and its relationship with the academic performance of medical students during the coronavirus disease 2019 (COVID-19) pandemic in Iran. Methods: In this descriptive-correlational research, 261 medical students participated in Iran. The standard Depression, Anxiety, and Stress Scale (DASS-21) and the Pennsylvania Standard Worry Questionnaire (PSWQ) were used to collect data. Similarly, students’ grade point averages (GPAs) were considered an indicator of their academic performance. The statistical analysis was carried out using IBM’s Statistical Package for Social Sciences (SPSS) software version 25.0. The level of statistical significance was reported at P","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"218 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134545514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cognitive-behavioral therapy (CBT) has always been used as an effective method to improve emotion regulation and train patients to reduce mental disorders. Therefore, the current research has investigated the effectiveness of CBT on emotion self-regulation and its components in patients with schizophrenia. Methods: This research was a semi-experimental study with an experimental group and a control group. The statistical population of this study included all patients with schizophrenia in Hayat Rehabilitation and Treatment Center for Chronic Mental Patients in 2021 - 2022. Among the above study population, a total of 30 people (n = 15 per group) with confirmed schizophrenia were selected and studied using the convenience sampling method. The experimental group received CBT for eight 60-minute sessions, but the control group received no training. Both groups completed the Self-Regulation Inventory (SRI-25) at the pre-test and post-test stages. The data of this study were analyzed by multivariate analysis of variance (MANOVA) using SPSS software version 16. Results: Data analysis showed that after 8 sessions of CBT in the experimental group, the mean scores of emotion regulation and its sub-components significantly increased in the experimental group than in the control group (0.05). Conclusions: Therefore, considering the effectiveness of CBT in improving the emotion self-regulation dimensions, it is advisable to use this training to improve emotion self-regulation in patients with schizophrenia.
{"title":"The Effectiveness of Cognitive Behavioral Therapy on Emotion Self-Regulation and its Components in Patients with Schizophrenia: A Semi-Experimental Study","authors":"Hanieh Nobakht, Mehrdad Mazaheri Dasht Arjandi, Fatemeh Soghra Karbalaei Herafteh","doi":"10.5812/jjcdc-135134","DOIUrl":"https://doi.org/10.5812/jjcdc-135134","url":null,"abstract":"Background: Cognitive-behavioral therapy (CBT) has always been used as an effective method to improve emotion regulation and train patients to reduce mental disorders. Therefore, the current research has investigated the effectiveness of CBT on emotion self-regulation and its components in patients with schizophrenia. Methods: This research was a semi-experimental study with an experimental group and a control group. The statistical population of this study included all patients with schizophrenia in Hayat Rehabilitation and Treatment Center for Chronic Mental Patients in 2021 - 2022. Among the above study population, a total of 30 people (n = 15 per group) with confirmed schizophrenia were selected and studied using the convenience sampling method. The experimental group received CBT for eight 60-minute sessions, but the control group received no training. Both groups completed the Self-Regulation Inventory (SRI-25) at the pre-test and post-test stages. The data of this study were analyzed by multivariate analysis of variance (MANOVA) using SPSS software version 16. Results: Data analysis showed that after 8 sessions of CBT in the experimental group, the mean scores of emotion regulation and its sub-components significantly increased in the experimental group than in the control group (0.05). Conclusions: Therefore, considering the effectiveness of CBT in improving the emotion self-regulation dimensions, it is advisable to use this training to improve emotion self-regulation in patients with schizophrenia.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127604684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zeinab Darehshoori Mohammadi, Sassan Bavi, Farzaneh Human
Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders among school-age children. Objectives: This study aimed to evaluate the impact of transdiagnostic therapy on children with ADHD who also had behavioral-emotional disorders and experienced excessive mind wandering. Methods: This quasi-experimental study utilized a pretest-posttest design with a control group. The statistical population consisted of all college students referred to the West Health Center in 2019. A sample of 30 patients was selected, and they were randomly assigned to either the TDT intervention group (n = 15) or the control group (n = 15). The experimental group received TDT for eight sessions, with two 90-minute sessions per week, while the control group did not receive any treatment. The Rutter Children Behavior Questionnaire (RCBQ) and the Mind Excessively Wandering Scale (MEWS) were among the research tools used. A multivariate analysis of covariance was used to analyze the data. Results: The study included 30 participants who were children with an average age of 11.2 ± 1.2 years. In the experimental group, the average score for emotional and behavioral disorders decreased from 30.33 to 23.40, and the average score for mental wandering decreased from 18.93 to 15.26 after the intervention. In the control group, the average score for the RCBQ changed from 30.86 to 30.60, and the average score for the MEWQ changed from 19.06 to 18.86 after the intervention. The TDT is effective in reducing behavioral and emotional disorders, as well as excessive mind wandering, in children with ADHD (P < 0.05). Conclusions: Transdiagnostic therapy is effective in treating behavioral and emotional disorders, as well as excessive mind wandering in children with hyperactivity and attention deficit. Therefore, these individuals should incorporate transdiagnostic interventions alongside psychiatric therapies.
{"title":"Effectiveness of Transdiagnostic Therapy in Behavioral-Emotional Disorder and Excessive Mind Wandering in Children with Attention Deficit Hyperactivity Disorder: A Randomized Controlled Trial","authors":"Zeinab Darehshoori Mohammadi, Sassan Bavi, Farzaneh Human","doi":"10.5812/jjcdc-132186","DOIUrl":"https://doi.org/10.5812/jjcdc-132186","url":null,"abstract":"Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders among school-age children. Objectives: This study aimed to evaluate the impact of transdiagnostic therapy on children with ADHD who also had behavioral-emotional disorders and experienced excessive mind wandering. Methods: This quasi-experimental study utilized a pretest-posttest design with a control group. The statistical population consisted of all college students referred to the West Health Center in 2019. A sample of 30 patients was selected, and they were randomly assigned to either the TDT intervention group (n = 15) or the control group (n = 15). The experimental group received TDT for eight sessions, with two 90-minute sessions per week, while the control group did not receive any treatment. The Rutter Children Behavior Questionnaire (RCBQ) and the Mind Excessively Wandering Scale (MEWS) were among the research tools used. A multivariate analysis of covariance was used to analyze the data. Results: The study included 30 participants who were children with an average age of 11.2 ± 1.2 years. In the experimental group, the average score for emotional and behavioral disorders decreased from 30.33 to 23.40, and the average score for mental wandering decreased from 18.93 to 15.26 after the intervention. In the control group, the average score for the RCBQ changed from 30.86 to 30.60, and the average score for the MEWQ changed from 19.06 to 18.86 after the intervention. The TDT is effective in reducing behavioral and emotional disorders, as well as excessive mind wandering, in children with ADHD (P < 0.05). Conclusions: Transdiagnostic therapy is effective in treating behavioral and emotional disorders, as well as excessive mind wandering in children with hyperactivity and attention deficit. Therefore, these individuals should incorporate transdiagnostic interventions alongside psychiatric therapies.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115517096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rahim Peimane, N. Elahi, N. Sayadi, M. Haghighizadeh, M. Bigdeli
Background: The proper decision-making on weaning patients from the ventilator, removing the endotracheal tube, reducing complications, and the way of cooperating between doctor and nurse is always one of the concerns of intensive care unit (ICU) nurses. Objectives: This study aimed to determine the effect of clinical decision-making based on interactive education on the successful extubations of patients in the ICU. Methods: This quasi-experimental study was conducted on 50 nurses in the ICU of Ganjavian Hospital in Dezful, Iran, within August-December 2021. The nurses were selected based on inclusion criteria and randomly assigned into intervention and control groups. Clinical decision-making training regarding extubation was provided interactively for one month in five sessions in the experimental group. The data were obtained using a demographic information questionnaire, the Clinical Decision-Making Questionnaire by Lauri et al., and extubation checklist and analyzed using SPSS software (version 24) using descriptive and inferential statistics (i.e., chi-square test, covariance, independent t-test, and paired t-test). Results: No difference was observed between the two groups in terms of demographic information (P < 0.05). After the intervention, the mean score of nurses’ clinical decisions and the number of successful extubations in the experimental group were higher than in the control group, with a statistically significant difference (P = 0.014). Conclusions: Interactive training effectively improves decision-making skills concerning successful extubations. Therefore, it is suggested to use this method in educational programs to improve the clinical decision-making of nurses, students, and nursing managers.
{"title":"Effect of Clinical Decision-Making Based on Interactive Training on Successful Extubations in Intensive Care Unit Patients","authors":"Rahim Peimane, N. Elahi, N. Sayadi, M. Haghighizadeh, M. Bigdeli","doi":"10.5812/jjcdc-136158","DOIUrl":"https://doi.org/10.5812/jjcdc-136158","url":null,"abstract":"Background: The proper decision-making on weaning patients from the ventilator, removing the endotracheal tube, reducing complications, and the way of cooperating between doctor and nurse is always one of the concerns of intensive care unit (ICU) nurses. Objectives: This study aimed to determine the effect of clinical decision-making based on interactive education on the successful extubations of patients in the ICU. Methods: This quasi-experimental study was conducted on 50 nurses in the ICU of Ganjavian Hospital in Dezful, Iran, within August-December 2021. The nurses were selected based on inclusion criteria and randomly assigned into intervention and control groups. Clinical decision-making training regarding extubation was provided interactively for one month in five sessions in the experimental group. The data were obtained using a demographic information questionnaire, the Clinical Decision-Making Questionnaire by Lauri et al., and extubation checklist and analyzed using SPSS software (version 24) using descriptive and inferential statistics (i.e., chi-square test, covariance, independent t-test, and paired t-test). Results: No difference was observed between the two groups in terms of demographic information (P < 0.05). After the intervention, the mean score of nurses’ clinical decisions and the number of successful extubations in the experimental group were higher than in the control group, with a statistically significant difference (P = 0.014). Conclusions: Interactive training effectively improves decision-making skills concerning successful extubations. Therefore, it is suggested to use this method in educational programs to improve the clinical decision-making of nurses, students, and nursing managers.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132822747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haniye Salimi, A. Salah, Mozhde Heidari, M. Moghadami, M. Fallahi, F. Zand, Mohammadhossein Karimi
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has affected over 200 million individuals worldwide, and finding a treatment to control and eradicate the disease is considered a critical issue. Different drugs and therapies have been used since the beginning of the pandemic; however, effective infection control has not been achieved. Convalescent plasma (CP) that contains immune factors (neutralizing antibodies and inflammatory) can be an effective way to treat some infections, as it was previously used to control the pandemic. Objectives: the present study aimed to assess the effect of CP infusion on some clinical indicators of coronavirus disease 2019 (COVID-19). Methods: This study investigated the effects of CP treatment on some clinical factors, such as C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), and D-dimer among 125 patients in two groups, including a CP-treated group and a non-treated control group, in Ali-Asghar Hospital of Shiraz, Iran. Results: Mortality rate analysis between CP-treated and control groups showed a 31% reduction (53% and 84% mortality in CP-treated and non-treated control groups, respectively). In addition, the clinical factor analysis of CP-treated patients showed a significant change in D-dimer on the seventh day (P = 0.036) and oxygen saturation (SpO2) (P = 0.00), lymphocyte count (P = 0.00), platelet (P = 0.005), and ESR (P = 0.007) between the first and fourth days of treatment. Moreover, CP-treated patients were separated into two age groups. It was observed that on the fourth day, the rate of SpO2 and lymphocyte count were significantly different in patients under 50 years compared to patients ≥ 50 years (P = 0.004 and P = 0.011, respectively); a similar finding was shown for lymphocyte count on the seventh day after CP infusion (P = 0.012). The results also revealed a significant difference between males and females in lymphocyte count after CP treatment on the fourth and seventh days (P = 0.006 and P = 0.042, respectively). Conclusions: The results demonstrated the potential impact of CP infusion on the laboratory data of COVID-19-infected patients. Accordingly, this method could have a practical effect on reducing and even suppressing inflammation, infection, and mortality rate among these patients. However, further studies are needed to obtain more accurate results.
{"title":"Assessment of Laboratory and Clinical Data in COVID-19 Patients Treated by Convalescent Plasma","authors":"Haniye Salimi, A. Salah, Mozhde Heidari, M. Moghadami, M. Fallahi, F. Zand, Mohammadhossein Karimi","doi":"10.5812/jjcdc-132001","DOIUrl":"https://doi.org/10.5812/jjcdc-132001","url":null,"abstract":"Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has affected over 200 million individuals worldwide, and finding a treatment to control and eradicate the disease is considered a critical issue. Different drugs and therapies have been used since the beginning of the pandemic; however, effective infection control has not been achieved. Convalescent plasma (CP) that contains immune factors (neutralizing antibodies and inflammatory) can be an effective way to treat some infections, as it was previously used to control the pandemic. Objectives: the present study aimed to assess the effect of CP infusion on some clinical indicators of coronavirus disease 2019 (COVID-19). Methods: This study investigated the effects of CP treatment on some clinical factors, such as C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), and D-dimer among 125 patients in two groups, including a CP-treated group and a non-treated control group, in Ali-Asghar Hospital of Shiraz, Iran. Results: Mortality rate analysis between CP-treated and control groups showed a 31% reduction (53% and 84% mortality in CP-treated and non-treated control groups, respectively). In addition, the clinical factor analysis of CP-treated patients showed a significant change in D-dimer on the seventh day (P = 0.036) and oxygen saturation (SpO2) (P = 0.00), lymphocyte count (P = 0.00), platelet (P = 0.005), and ESR (P = 0.007) between the first and fourth days of treatment. Moreover, CP-treated patients were separated into two age groups. It was observed that on the fourth day, the rate of SpO2 and lymphocyte count were significantly different in patients under 50 years compared to patients ≥ 50 years (P = 0.004 and P = 0.011, respectively); a similar finding was shown for lymphocyte count on the seventh day after CP infusion (P = 0.012). The results also revealed a significant difference between males and females in lymphocyte count after CP treatment on the fourth and seventh days (P = 0.006 and P = 0.042, respectively). Conclusions: The results demonstrated the potential impact of CP infusion on the laboratory data of COVID-19-infected patients. Accordingly, this method could have a practical effect on reducing and even suppressing inflammation, infection, and mortality rate among these patients. However, further studies are needed to obtain more accurate results.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123420632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ghazaleh Fazli, Malieheh Arab, Samaneh Saraeian, B. Ghavami, B. Nouri, Tayebeh Jahede Bozorgan
Background: Osteoporosis might result in an increased risk of bone fracture. Diagnosis of osteoporosis results in proper treatment and reduction of fracture rate. Objectives: This study aimed to construct a predictive model of osteoporosis case finding in Iranian women. Methods: A prospective diagnostic value study was designed, enrolling 317 asymptomatic women 50 years old or more referred for screening, at the Imam Hossein Medical Center, Tehran, Iran, for two years. The data was collected with the census method. A questionnaire including risk factors was completed, and bone mass densitometry (BMD) was done by the dual-energy X-ray absorptiometry (DXA) method in all cases. According to standard curves, bone density of the femur and lumbar spine clarified osteoporosis status for each person. In the first step, univariate analysis with osteoporosis as the main outcome did use the chi-squared test, independent sample t-test. In the next step, factors with a P-value of less than 0.2 were included in the multivariate logistic model, and a predictive model was constructed. The goodness of fit test was applied to assess the model building. The area under the curve (AUC) calculated for the model and the best cut-point for risk of menopause according to the Youden index were determined. The significance level was set at 0.05 for statistical analysis. Statistical analyses did use the program SSPS version 17.0 (SPSS, Inc., Chicago, IL, USA). Results: In 317 cases of the present study, the mean age of the population was 52.46 years old. Ninety-nine (%31.2) of these asymptomatic women revealed osteoporosis on the BMD test. Age and family history of osteoporosis were risk factors, and BMI, parity, and menopause age were protective factors for osteoporosis. Constructed model of osteoporosis prediction was as follows: (age × 0.149) + (family history × 0.963) - (BMI × 0.088) - (menopause age × 0.097) - (parity × 0.80). Optimal cutoff = 0.336 based on Youden method was chosen to predict the risk of osteoporosis. Conclusions: BMD test in Iran in more than 50 years old might find positive osteoporotic cases in at least 23.8%. BMD test in Iran in more than 50 years old might find positive osteoporotic cases in at least 23.8%. A model of osteoporosis probability constructed based on age, family history, menopause age, and parity in the present study can predict women at risk of osteoporosis.
{"title":"Diagnostic Value of Clinical Parameters for the Prediction of Osteoporosis in Menopause Iranian Women","authors":"Ghazaleh Fazli, Malieheh Arab, Samaneh Saraeian, B. Ghavami, B. Nouri, Tayebeh Jahede Bozorgan","doi":"10.5812/jjcdc-112758","DOIUrl":"https://doi.org/10.5812/jjcdc-112758","url":null,"abstract":"Background: Osteoporosis might result in an increased risk of bone fracture. Diagnosis of osteoporosis results in proper treatment and reduction of fracture rate. Objectives: This study aimed to construct a predictive model of osteoporosis case finding in Iranian women. Methods: A prospective diagnostic value study was designed, enrolling 317 asymptomatic women 50 years old or more referred for screening, at the Imam Hossein Medical Center, Tehran, Iran, for two years. The data was collected with the census method. A questionnaire including risk factors was completed, and bone mass densitometry (BMD) was done by the dual-energy X-ray absorptiometry (DXA) method in all cases. According to standard curves, bone density of the femur and lumbar spine clarified osteoporosis status for each person. In the first step, univariate analysis with osteoporosis as the main outcome did use the chi-squared test, independent sample t-test. In the next step, factors with a P-value of less than 0.2 were included in the multivariate logistic model, and a predictive model was constructed. The goodness of fit test was applied to assess the model building. The area under the curve (AUC) calculated for the model and the best cut-point for risk of menopause according to the Youden index were determined. The significance level was set at 0.05 for statistical analysis. Statistical analyses did use the program SSPS version 17.0 (SPSS, Inc., Chicago, IL, USA). Results: In 317 cases of the present study, the mean age of the population was 52.46 years old. Ninety-nine (%31.2) of these asymptomatic women revealed osteoporosis on the BMD test. Age and family history of osteoporosis were risk factors, and BMI, parity, and menopause age were protective factors for osteoporosis. Constructed model of osteoporosis prediction was as follows: (age × 0.149) + (family history × 0.963) - (BMI × 0.088) - (menopause age × 0.097) - (parity × 0.80). Optimal cutoff = 0.336 based on Youden method was chosen to predict the risk of osteoporosis. Conclusions: BMD test in Iran in more than 50 years old might find positive osteoporotic cases in at least 23.8%. BMD test in Iran in more than 50 years old might find positive osteoporotic cases in at least 23.8%. A model of osteoporosis probability constructed based on age, family history, menopause age, and parity in the present study can predict women at risk of osteoporosis.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126296330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nilofar Salehi, S. Sohrevardi, Shahriyar Salehi Tali, G. Afzal
Background: The coronavirus pandemic (COVID-19) seriously threatens the health and life of people with underlying diseases, such as patients undergoing hemodialysis. Objectives: This study aimed to determine the clinical characteristics of COVID-19 patients with chronic kidney disease undergoing hemodialysis referring to hemodialysis centers affiliated with the Shahrekord University of Medical Sciences between 2019 and 2021. Methods: This was a retrospective descriptive-analytical study with a sample size of 144 hemodialysis patients with COVID-19. The data were collected by a demographic questionnaire, a checklist based on the presence of underlying diseases, the cause of the kidney failure, drugs received during hemodialysis, medications used for COVID, the result of COVID-19 treatment, and outpatient or inpatient treatment, and the checklist of laboratory indices extracted from the patient’s medical records. Data were analyzed by SPSS version 20 and descriptive and analytical statistical tests. Results: The average age was 57.2 ± 14.42 years, and 64.6% were men, 35.4% were women, 64.6% recovered, and 35.4% died, although 42.4% of patients were treated on an outpatient basis, and 57.6% needed hospitalization. Also, 93.7% of patients were vaccinated. The average duration of hemodialysis treatment was 6.44 years, and diabetes accounted for 31.1% of the causes of kidney failure, and these people had a higher chance of mortality. Positive c-reactive protein (CRP) results were found in 72.2% of patients, and 54.2% had a positive erythrocyte sedimentation rate (ESR). In addition, 22.2% of patients used mechanical ventilation, and 88.2% had positive PCR results. Iron, ferritin, albumin, and hemoglobin index were lower than normal in all patients. Patients with positive hepatitis B antigens were treated with sofosbuvir. In outpatient treatment, 65.6% used remdesivir, and 70.5% used dexamethasone. Regarding inpatient treatment, 75.9% used methylprednisolone, 56.6% used tocilizumab, and 54.2% used pirfenidone. Conclusions: The rate of death and hospitalization in hemodialysis patients with COVID-19 was higher than that of normal people. Diabetes increases the chance of morbidity and mortality of COVID-19 in hemodialysis patients. The reduction of hemoglobin, iron, ferritin, and albumin weakened the therapeutic response of hemodialysis patients to COVID-19 and increased the chance of death. Although various drugs were used in the treatment of COVID-19 hemodialysis patients, the patients did not follow a single regimen.
背景:新型冠状病毒大流行(COVID-19)严重威胁着血液透析患者等基础性疾病患者的健康和生命。目的:本研究旨在确定2019 - 2021年在沙赫里科德医科大学附属血液透析中心接受血液透析的COVID-19慢性肾病患者的临床特征。方法:这是一项回顾性描述性分析研究，样本量为144例COVID-19血液透析患者。数据通过人口统计问卷、基于基础疾病、肾衰竭原因、血液透析期间使用的药物、用于治疗COVID的药物、COVID-19治疗结果、门诊或住院治疗的清单以及从患者医疗记录中提取的实验室指标清单收集。数据分析采用SPSS version 20及描述性和分析性统计检验。结果:平均年龄为57.2±14.42岁，男性占64.6%，女性占35.4%，康复率为64.6%，死亡率为35.4%，其中门诊占42.4%，住院占57.6%。此外，93.7%的患者接种了疫苗。血液透析治疗的平均持续时间为6.44年，糖尿病占肾衰竭原因的31.1%，这些人的死亡率更高。72.2%的患者c反应蛋白(CRP)阳性，54.2%的患者红细胞沉降率(ESR)阳性。此外，22.2%的患者使用机械通气，88.2%的患者PCR阳性。所有患者铁、铁蛋白、白蛋白、血红蛋白指数均低于正常水平。乙型肝炎抗原阳性患者用索非布韦治疗。在门诊治疗中，65.6%使用瑞德西韦，70.5%使用地塞米松。关于住院治疗，75.9%使用甲基强的松龙，56.6%使用托珠单抗，54.2%使用吡非尼酮。结论:血液透析患者COVID-19的死亡率和住院率均高于正常人。糖尿病增加了血液透析患者COVID-19发病率和死亡率的机会。血红蛋白、铁、铁蛋白和白蛋白的降低削弱了血液透析患者对COVID-19的治疗反应，增加了死亡的机会。尽管在治疗COVID-19血液透析患者时使用了各种药物，但患者并没有遵循单一的治疗方案。
{"title":"Clinical Characteristics of Hemodialysis Patients with COVID-19 Referred to Hemodialysis Centers Affiliated with the Shahrekord University of Medical Sciences Between 2020 and 2021","authors":"Nilofar Salehi, S. Sohrevardi, Shahriyar Salehi Tali, G. Afzal","doi":"10.5812/jjcdc-135670","DOIUrl":"https://doi.org/10.5812/jjcdc-135670","url":null,"abstract":"Background: The coronavirus pandemic (COVID-19) seriously threatens the health and life of people with underlying diseases, such as patients undergoing hemodialysis. Objectives: This study aimed to determine the clinical characteristics of COVID-19 patients with chronic kidney disease undergoing hemodialysis referring to hemodialysis centers affiliated with the Shahrekord University of Medical Sciences between 2019 and 2021. Methods: This was a retrospective descriptive-analytical study with a sample size of 144 hemodialysis patients with COVID-19. The data were collected by a demographic questionnaire, a checklist based on the presence of underlying diseases, the cause of the kidney failure, drugs received during hemodialysis, medications used for COVID, the result of COVID-19 treatment, and outpatient or inpatient treatment, and the checklist of laboratory indices extracted from the patient’s medical records. Data were analyzed by SPSS version 20 and descriptive and analytical statistical tests. Results: The average age was 57.2 ± 14.42 years, and 64.6% were men, 35.4% were women, 64.6% recovered, and 35.4% died, although 42.4% of patients were treated on an outpatient basis, and 57.6% needed hospitalization. Also, 93.7% of patients were vaccinated. The average duration of hemodialysis treatment was 6.44 years, and diabetes accounted for 31.1% of the causes of kidney failure, and these people had a higher chance of mortality. Positive c-reactive protein (CRP) results were found in 72.2% of patients, and 54.2% had a positive erythrocyte sedimentation rate (ESR). In addition, 22.2% of patients used mechanical ventilation, and 88.2% had positive PCR results. Iron, ferritin, albumin, and hemoglobin index were lower than normal in all patients. Patients with positive hepatitis B antigens were treated with sofosbuvir. In outpatient treatment, 65.6% used remdesivir, and 70.5% used dexamethasone. Regarding inpatient treatment, 75.9% used methylprednisolone, 56.6% used tocilizumab, and 54.2% used pirfenidone. Conclusions: The rate of death and hospitalization in hemodialysis patients with COVID-19 was higher than that of normal people. Diabetes increases the chance of morbidity and mortality of COVID-19 in hemodialysis patients. The reduction of hemoglobin, iron, ferritin, and albumin weakened the therapeutic response of hemodialysis patients to COVID-19 and increased the chance of death. Although various drugs were used in the treatment of COVID-19 hemodialysis patients, the patients did not follow a single regimen.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"615 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120869114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahboobeh Shojaei, S. Shahrabi, Nastaran Khodakarim, Mehran Amrovani, A. Salah, Zohre Saleh Nassaj, M. Esmaeili
Background: Coronavirus disease 2019 (COVID-19) was first detected in December 2019 in Wuhan, China. Different treatments have been used to fight against the virus; however, one of the most effective and accessible is convalescent plasma therapy (CPT). Objectives: The present study investigated the effect of CPT on improving the clinical conditions of COVID-19 patients. Methods: This study was conducted on 440 individuals, including 220 COVID-19-recovered individuals as plasma donors and 220 plasma recipients, in Shiraz, Fars province, Iran, from May 2020 to February 2021 using random sampling. After complete recovery from COVID-19, patients were recalled for apheresis and plasma isolation for convalescent plasma (CP) preparation; they were referred to the blood donation centers of Shiraz. According to the hospital request, compatible and related plasma was sent for COVID-19-hospitalized patients. At the same time, hospitals were asked to send the clinical condition documents of the patients based on the medical records and the outcomes after CPT. The Iranian Blood Transfusion Organization evaluated the results. Results: The median antibody titer was 1300. Titers higher and lower than 1300 were considered high and low, respectively. Blood group O had 54 times higher antibody titers above 1300 than other blood groups (odds ratio (OR) = 54, confidence interval (CI): 19.5 - 205.3, P < 0.001). Additionally, most deceased cases received plasma with antibody titers less than 1300 (OR = 0.08, CI: 0.009 - 0.36, P < 0.001). Nevertheless, most discharged patients received plasma with antibody titers higher than 1300 (OR = 1.5, CI: 1.06 - 2.3, P = 0.01). Moreover, when donors’ antibody titer was higher than 1300, the chance of survival increased by 50%. In addition, the results of this study showed higher mortality in patients whose volume of received plasma was less than 387 mL (OR = 0.3, CI: 0.10 - 0.91, P = 0.018). However, patients who received more than 387 mL CP were more likely to discharge (OR = 5.7, CI: 3.7 - 8.8, P < 0.001). Conclusions: Using blood group O plasma with a minimum volume of 387 mL can be very effective in improving the clinical symptoms of patients with COVID-19 and increasing the chances of survival for these patients.
背景:2019冠状病毒病(COVID-19)于2019年12月在中国武汉首次发现。人们使用了不同的治疗方法来对抗这种病毒;然而，最有效和最容易获得的是恢复期血浆治疗(CPT)。目的:探讨CPT对改善COVID-19患者临床状况的作用。方法:本研究于2020年5月至2021年2月在伊朗法尔斯省设拉子采用随机抽样方法，对440名个体进行了研究，其中包括220名covid -19康复个体作为血浆供体和220名血浆受体。COVID-19完全康复后，召回患者进行采血和血浆分离，制备恢复期血浆(CP);他们被转到设拉子的献血中心。根据医院要求，为新冠肺炎住院患者发送了兼容的相关血浆。同时，要求医院根据患者的医疗记录和CPT后的结果发送患者的临床状况文件。伊朗输血组织对结果进行了评估。结果:抗体效价中位数为1300。高于和低于1300分别被认为是高和低滴度。O型血在1300以上抗体滴度比其他血型高54倍(优势比(OR) = 54，置信区间(CI): 19.5 ~ 205.3, P < 0.001)。此外，大多数死亡患者的血浆抗体滴度低于1300 (OR = 0.08, CI: 0.009 ~ 0.36, P < 0.001)。但出院患者血浆抗体滴度大多高于1300 (OR = 1.5, CI: 1.06 ~ 2.3, P = 0.01)。此外，当供体抗体滴度高于1300时，生存机会增加50%。此外，本研究结果显示，接受血浆容量小于387 mL的患者死亡率更高(OR = 0.3, CI: 0.10 - 0.91, P = 0.018)。然而，接受超过387 mL CP的患者更有可能出院(OR = 5.7, CI: 3.7 - 8.8, P < 0.001)。结论:使用最小容量为387 mL的O型血浆可非常有效地改善COVID-19患者的临床症状，提高患者的生存机会。
{"title":"Effect of Convalescent Plasma Therapy on COVID-19 Patients: A Retrospective Study","authors":"Mahboobeh Shojaei, S. Shahrabi, Nastaran Khodakarim, Mehran Amrovani, A. Salah, Zohre Saleh Nassaj, M. Esmaeili","doi":"10.5812/jjcdc-133599","DOIUrl":"https://doi.org/10.5812/jjcdc-133599","url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) was first detected in December 2019 in Wuhan, China. Different treatments have been used to fight against the virus; however, one of the most effective and accessible is convalescent plasma therapy (CPT). Objectives: The present study investigated the effect of CPT on improving the clinical conditions of COVID-19 patients. Methods: This study was conducted on 440 individuals, including 220 COVID-19-recovered individuals as plasma donors and 220 plasma recipients, in Shiraz, Fars province, Iran, from May 2020 to February 2021 using random sampling. After complete recovery from COVID-19, patients were recalled for apheresis and plasma isolation for convalescent plasma (CP) preparation; they were referred to the blood donation centers of Shiraz. According to the hospital request, compatible and related plasma was sent for COVID-19-hospitalized patients. At the same time, hospitals were asked to send the clinical condition documents of the patients based on the medical records and the outcomes after CPT. The Iranian Blood Transfusion Organization evaluated the results. Results: The median antibody titer was 1300. Titers higher and lower than 1300 were considered high and low, respectively. Blood group O had 54 times higher antibody titers above 1300 than other blood groups (odds ratio (OR) = 54, confidence interval (CI): 19.5 - 205.3, P < 0.001). Additionally, most deceased cases received plasma with antibody titers less than 1300 (OR = 0.08, CI: 0.009 - 0.36, P < 0.001). Nevertheless, most discharged patients received plasma with antibody titers higher than 1300 (OR = 1.5, CI: 1.06 - 2.3, P = 0.01). Moreover, when donors’ antibody titer was higher than 1300, the chance of survival increased by 50%. In addition, the results of this study showed higher mortality in patients whose volume of received plasma was less than 387 mL (OR = 0.3, CI: 0.10 - 0.91, P = 0.018). However, patients who received more than 387 mL CP were more likely to discharge (OR = 5.7, CI: 3.7 - 8.8, P < 0.001). Conclusions: Using blood group O plasma with a minimum volume of 387 mL can be very effective in improving the clinical symptoms of patients with COVID-19 and increasing the chances of survival for these patients.","PeriodicalId":271852,"journal":{"name":"Jundishapur Journal of Chronic Disease Care","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133604424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：