{"title":"Innovative interventions and approaches for pediatric respiratory problems","authors":"Varinder Singh","doi":"10.4103/PRCM.PRCM_15_18","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_15_18","url":null,"abstract":"","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126102404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: We aimed to report our 3-year experience in modified HFNC (MHFNC) usage in young children with community-acquired pneumonia in infectious diseases ward and to identify factors associated with MHFNC failure. Materials and Methods: A retrospective, cross-sectional study of pediatric patients, aged <5 years, with community-acquired pneumonia, who were treated with MHFNC at infectious diseases from August 2012 to December 2015 were recruited. MHFNC failure was defined as a need for further respiratory support within 48 h after initiating MHFNC. Patients: Ninety-nine patients with community-acquired pneumonia were included in this study. Setting: A tertiary care hospital. Measurements and Results: Ninety-nine children (median age of 14 months, body weight 8.6 + 3.1 kg) were included. Ninety-two children (93%) were successfully treated with MHFNC and only seven (7%) were in the failure group. The maximal flow was 3 L/kg/min. Lower oxygen saturation (SpO2)/fraction of inspired oxygen (FiO2) ratio (<264) and higher FiO2 requirement were found to be associated with failure. Maximum FiO2 requirement >0.5 had high odds ratios (22.25) to develop MHFNC failure. No serious complication from MHFNC was found. Conclusions: MHFNC is a practical respiratory support in young children with pneumonia. SpO2/FiO2 ratio (<264) and FiO2 requirement >0.5 is a risk factor for MHFNC failure.
{"title":"Modified high-flow nasal cannula in young children with pneumonia: A 3-year retrospective study","authors":"Issaranee Vareesunthorn, A. Preutthipan","doi":"10.4103/PRCM.PRCM_2_18","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_2_18","url":null,"abstract":"Objectives: We aimed to report our 3-year experience in modified HFNC (MHFNC) usage in young children with community-acquired pneumonia in infectious diseases ward and to identify factors associated with MHFNC failure. Materials and Methods: A retrospective, cross-sectional study of pediatric patients, aged <5 years, with community-acquired pneumonia, who were treated with MHFNC at infectious diseases from August 2012 to December 2015 were recruited. MHFNC failure was defined as a need for further respiratory support within 48 h after initiating MHFNC. Patients: Ninety-nine patients with community-acquired pneumonia were included in this study. Setting: A tertiary care hospital. Measurements and Results: Ninety-nine children (median age of 14 months, body weight 8.6 + 3.1 kg) were included. Ninety-two children (93%) were successfully treated with MHFNC and only seven (7%) were in the failure group. The maximal flow was 3 L/kg/min. Lower oxygen saturation (SpO2)/fraction of inspired oxygen (FiO2) ratio (<264) and higher FiO2 requirement were found to be associated with failure. Maximum FiO2 requirement >0.5 had high odds ratios (22.25) to develop MHFNC failure. No serious complication from MHFNC was found. Conclusions: MHFNC is a practical respiratory support in young children with pneumonia. SpO2/FiO2 ratio (<264) and FiO2 requirement >0.5 is a risk factor for MHFNC failure.","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125106590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Tuberculosis (TB) is a significant problem among children in Indonesia. While pulmonary TB has been widely reported, information on extrapulmonary TB (EPTB) among children in Indonesia has not been well documented. Aims: The aim of this study is to document demographic and clinical characteristics and outcome of EPTB in children. Settings and Design: A retrospective study was conducted in Dr. Sardjito Hospital, Yogyakarta, Indonesia. Subjects and Methods: Medical records were reviewed for all children aged younger than 18 years diagnosed with EPTB and admitted to this hospital between 2009 and 2015. Results: Fifty-three patients with EPTB were admitted to the hospital during the study period. EPTB was more common in children aged >5 years, with median (interquartile range) age of presentation at 12.5 years (4.1–14.7 years). Major presenting symptoms were fever (72%), cough (55%), and weight loss (38%). Common types of EPTB were meningitis (28%), miliary TB (23%), and osteoarthritis (20%). The diagnosis was confirmed by either acid-fast bacilli smear or GeneXpert MTB/rifampicin (RIF) in 13 patients. Evidence of TB infection was documented in 26 % of children with positive result of tuberculin skin test. Mycobacterium TB was detected by GeneXpert MTB/RIF in 23% of children. The mortality rate was 19% which mostly occured in children with meningitis (60%). Conclusion: EPTB was commonly seen in older children, and tuberculous meningitis was both the most common type and cause of death of EPTB in our setting.
{"title":"Clinical profile and outcome of extrapulmonary tuberculosis in children in Indonesia","authors":"R. Triasih, R. Helmi, I. Laksanawati","doi":"10.4103/PRCM.PRCM_10_18","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_10_18","url":null,"abstract":"Context: Tuberculosis (TB) is a significant problem among children in Indonesia. While pulmonary TB has been widely reported, information on extrapulmonary TB (EPTB) among children in Indonesia has not been well documented. Aims: The aim of this study is to document demographic and clinical characteristics and outcome of EPTB in children. Settings and Design: A retrospective study was conducted in Dr. Sardjito Hospital, Yogyakarta, Indonesia. Subjects and Methods: Medical records were reviewed for all children aged younger than 18 years diagnosed with EPTB and admitted to this hospital between 2009 and 2015. Results: Fifty-three patients with EPTB were admitted to the hospital during the study period. EPTB was more common in children aged >5 years, with median (interquartile range) age of presentation at 12.5 years (4.1–14.7 years). Major presenting symptoms were fever (72%), cough (55%), and weight loss (38%). Common types of EPTB were meningitis (28%), miliary TB (23%), and osteoarthritis (20%). The diagnosis was confirmed by either acid-fast bacilli smear or GeneXpert MTB/rifampicin (RIF) in 13 patients. Evidence of TB infection was documented in 26 % of children with positive result of tuberculin skin test. Mycobacterium TB was detected by GeneXpert MTB/RIF in 23% of children. The mortality rate was 19% which mostly occured in children with meningitis (60%). Conclusion: EPTB was commonly seen in older children, and tuberculous meningitis was both the most common type and cause of death of EPTB in our setting.","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"19 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132123195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suppurative lungs, pneumothorax and 6-min walk test in children","authors":"A. Preutthipan","doi":"10.4103/PRCM.PRCM_8_18","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_8_18","url":null,"abstract":"","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123045940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Wong, E. Chan, D. Ng, K. Kwok, Ada Yip, Shuk-yu Leung
Aim: The aim of the study was to evaluate the correlation between the 6-min walk test (6MWT) and the cardiopulmonary exercise test (CPET) in Chinese pediatric patients. Methods: A retrospective review was undertaken for Chinese patients with exercise intolerance who had undergone both 6MWT and CPET on the same day over 21 months. Pearson's correlation analysis was used to examine the correlation between the 6-min walk distance (6MWD) and the maximum oxygen uptake (VO2 max). The 6MWD was defined as abnormal if <10th percentile of height-matched reference, and the VO2 maxwas defined as abnormal if <80% predicted. Results: Twenty-nine patients with a mean age of 14.3 ± 3.6 years were included in the study. The correlation coefficient (r) between the 6MWD and the VO2 maxwas 0.457 with P = 0.013. Twenty-six (three excluded as no reference for VO2 maxwas available for age <10 years) patients were analyzed. Using CPET as the gold standard for functional exercise capacity, 6MWT had a positive predictive value (PPV) of 92%, negative predictive value of 29%, sensitivity of 52%, specificity of 80%, and accuracy of 58% for assessing exercise capacity. Conclusion: 6MWT had a high PPV for abnormal CPET. It could still be used as a simple tool to evaluate patients with exercise intolerance.
目的:本研究的目的是评估中国儿科患者6分钟步行试验(6MWT)与心肺运动试验(CPET)的相关性。方法:回顾性分析21个月内同时接受6MWT和CPET治疗的中国运动不耐受患者。采用Pearson相关分析检验6 min步行距离(6MWD)与最大摄氧量(VO2 max)之间的相关性。6MWD <高度匹配参考值的10%定义为异常，VO2 max <预测值的80%定义为异常。结果:29例患者入组，平均年龄14.3±3.6岁。6MWD与VO2 max的相关系数r为0.457,P = 0.013。分析了26例患者(其中3例因年龄<10岁无VO2最大值参考而被排除在外)。以CPET作为功能性运动能力的金标准，6MWT评估运动能力的阳性预测值(PPV)为92%，阴性预测值为29%，敏感性为52%，特异性为80%，准确性为58%。结论:6MWT对异常CPET具有较高的PPV。它仍然可以作为一种简单的工具来评估运动不耐受患者。
{"title":"Correlation between 6-min walk test and cardiopulmonary exercise test in Chinese patients","authors":"P. Wong, E. Chan, D. Ng, K. Kwok, Ada Yip, Shuk-yu Leung","doi":"10.4103/PRCM.PRCM_24_17","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_24_17","url":null,"abstract":"Aim: The aim of the study was to evaluate the correlation between the 6-min walk test (6MWT) and the cardiopulmonary exercise test (CPET) in Chinese pediatric patients. Methods: A retrospective review was undertaken for Chinese patients with exercise intolerance who had undergone both 6MWT and CPET on the same day over 21 months. Pearson's correlation analysis was used to examine the correlation between the 6-min walk distance (6MWD) and the maximum oxygen uptake (VO2 max). The 6MWD was defined as abnormal if <10th percentile of height-matched reference, and the VO2 maxwas defined as abnormal if <80% predicted. Results: Twenty-nine patients with a mean age of 14.3 ± 3.6 years were included in the study. The correlation coefficient (r) between the 6MWD and the VO2 maxwas 0.457 with P = 0.013. Twenty-six (three excluded as no reference for VO2 maxwas available for age <10 years) patients were analyzed. Using CPET as the gold standard for functional exercise capacity, 6MWT had a positive predictive value (PPV) of 92%, negative predictive value of 29%, sensitivity of 52%, specificity of 80%, and accuracy of 58% for assessing exercise capacity. Conclusion: 6MWT had a high PPV for abnormal CPET. It could still be used as a simple tool to evaluate patients with exercise intolerance.","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133092436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A chronic neutrophil dominated bronchitis also known variously as PBB and CSLD is relatively common in childhood. There are numerous risk factors that may contribute to the development of a chronic bronchitis [inc viral LRTIs, malacia, aspiration, poorly controlled asthma etc.]. In most cases a specific significant on-going risk factor such as CF is not identified. It is under-diagnosed due to lack of awareness (if you do not know something exists you will never diagnose it). It is commonly mis-diagnosed as 'asthma' or 'recurrent chest infections'. Diagnosis is based on pattern recognition and response to treatment analogous to accurate diagnosis of asthma. Response to treatment must be dramatic and unequivocal to make a definite diagnosis. Beware regression to the mean PBB is a biofilm disease leading to challenges in treatment. A PBB is the cause of most cases of 'bronchiectasis'. Bronchiectasis is a radiological or pathological appearance, not a disease. Most cases are curable in the absence of a major underlying risk factor such as cystic fibrosis, PCD or significant immunodeficiency. Hence bronchiectasis is a largely preventable radiological appearance.
{"title":"'Suppurative lung disease' in children","authors":"M. Everard","doi":"10.4103/PRCM.PRCM_6_18","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_6_18","url":null,"abstract":"A chronic neutrophil dominated bronchitis also known variously as PBB and CSLD is relatively common in childhood. There are numerous risk factors that may contribute to the development of a chronic bronchitis [inc viral LRTIs, malacia, aspiration, poorly controlled asthma etc.]. In most cases a specific significant on-going risk factor such as CF is not identified. It is under-diagnosed due to lack of awareness (if you do not know something exists you will never diagnose it). It is commonly mis-diagnosed as 'asthma' or 'recurrent chest infections'. Diagnosis is based on pattern recognition and response to treatment analogous to accurate diagnosis of asthma. Response to treatment must be dramatic and unequivocal to make a definite diagnosis. Beware regression to the mean PBB is a biofilm disease leading to challenges in treatment. A PBB is the cause of most cases of 'bronchiectasis'. Bronchiectasis is a radiological or pathological appearance, not a disease. Most cases are curable in the absence of a major underlying risk factor such as cystic fibrosis, PCD or significant immunodeficiency. Hence bronchiectasis is a largely preventable radiological appearance.","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114793450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Studies about primary spontaneous pneumothorax (PSP) in pediatric patients are not as many as in adult patients since the incidence of PSP is lower in children than in adults. There are evidence-based guidelines for the management of PSP in adults, whereas, in children, the approach of PSP is mainly extrapolated from the adult guideline. In this article, aspects of incidence rate, epidemiology, and pathophysiology, diagnosis, management, and recurrence rate about pediatric PSP are discussed.
{"title":"Primary spontaneous pneumothorax in children: A literature review","authors":"P. Kuo, Bao-Ren Nong, Y. Huang, Y. Chiou","doi":"10.4103/PRCM.PRCM_3_18","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_3_18","url":null,"abstract":"Studies about primary spontaneous pneumothorax (PSP) in pediatric patients are not as many as in adult patients since the incidence of PSP is lower in children than in adults. There are evidence-based guidelines for the management of PSP in adults, whereas, in children, the approach of PSP is mainly extrapolated from the adult guideline. In this article, aspects of incidence rate, epidemiology, and pathophysiology, diagnosis, management, and recurrence rate about pediatric PSP are discussed.","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121282429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ta-Yu Liu, Hong-Ren Yu, Wei‐Ju Lee, Chih-Min Tsai, K. Kuo, Chih-Hao Chang, Yu-Tsun Su, Suiqiong Wang, C. Niu, K. Hsieh
Background: Mycoplasma pneumoniae is an important pathogenic bacterium that causes community-acquired pneumonia in children. Rapid and dependable laboratory diagnosis of M. pneumoniae infection is important for starting an appropriate antibiotic treatment. Currently, the serological testing for detection of M. pneumoniae immunoglobulin M (IgM) has been used to determine the presence of an acute infection, the results of which, depending on the laboratory facility, are not available immediately. Therefore, an optimal and instant detection method is needed to facilitate a more accurate diagnosis, which leads to the appropriate treatment of patients with M. pneumoniae-related pneumonia and reduces rates of resistance to antibiotics because of their misuse. Aims: Here, we investigated the clinical diagnostic value of a rapid detection kit for M. pneumoniae-specific IgM antibody, the BioCard Mycoplasma IgM rapid test, in the detection of a Mycoplasma infection in children. Material and Method: 44 pediatric patients with clinically suspected Mycoplasma infection were enrolled for study. Result: Among 82 Mycoplasma IgM-positive samples, 51 samples were detected to be positive using the BioCard rapid test. The sensitivity and specifi city of the kit were 62.20% (51/82) and 100% (16/16), respectively. The positive and negative predictive values were 100% (51/51) and 34.04% (16/47), respectively. Conslusion: In conclusion, the BioCard Mycoplasma IgM rapid test provides an accurate point-of-care diagnosis for M. pneumonia infection.
{"title":"Role of biocard Mycoplasma immunoglobulin M rapid test in the diagnosis of Mycoplasma pneumoniae infection","authors":"Ta-Yu Liu, Hong-Ren Yu, Wei‐Ju Lee, Chih-Min Tsai, K. Kuo, Chih-Hao Chang, Yu-Tsun Su, Suiqiong Wang, C. Niu, K. Hsieh","doi":"10.4103/PRCM.PRCM_30_17","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_30_17","url":null,"abstract":"Background: Mycoplasma pneumoniae is an important pathogenic bacterium that causes community-acquired pneumonia in children. Rapid and dependable laboratory diagnosis of M. pneumoniae infection is important for starting an appropriate antibiotic treatment. Currently, the serological testing for detection of M. pneumoniae immunoglobulin M (IgM) has been used to determine the presence of an acute infection, the results of which, depending on the laboratory facility, are not available immediately. Therefore, an optimal and instant detection method is needed to facilitate a more accurate diagnosis, which leads to the appropriate treatment of patients with M. pneumoniae-related pneumonia and reduces rates of resistance to antibiotics because of their misuse. Aims: Here, we investigated the clinical diagnostic value of a rapid detection kit for M. pneumoniae-specific IgM antibody, the BioCard Mycoplasma IgM rapid test, in the detection of a Mycoplasma infection in children. Material and Method: 44 pediatric patients with clinically suspected Mycoplasma infection were enrolled for study. Result: Among 82 Mycoplasma IgM-positive samples, 51 samples were detected to be positive using the BioCard rapid test. The sensitivity and specifi city of the kit were 62.20% (51/82) and 100% (16/16), respectively. The positive and negative predictive values were 100% (51/51) and 34.04% (16/47), respectively. Conslusion: In conclusion, the BioCard Mycoplasma IgM rapid test provides an accurate point-of-care diagnosis for M. pneumonia infection.","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125145106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4103/2543-0343.229323
{"title":"Erratum: Airway disease and environmental aeroallergens in eczematics approaching adulthood","authors":"","doi":"10.4103/2543-0343.229323","DOIUrl":"https://doi.org/10.4103/2543-0343.229323","url":null,"abstract":"","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"39 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130622205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pollution, infection and high flow","authors":"K. Wong","doi":"10.4103/PRCM.PRCM_4_18","DOIUrl":"https://doi.org/10.4103/PRCM.PRCM_4_18","url":null,"abstract":"","PeriodicalId":273845,"journal":{"name":"Pediatric Respirology and Critical Care Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115241136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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