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Circadian Sleep Disruption and Cancer Risk 昼夜睡眠中断与癌症风险
Pub Date : 2019-12-31 DOI: 10.33069/cim.2019.0022
S. Onen, F. Onen
In circadian sleep disruption is a major consequence of both night shift and chronic to artificial at night (LAN) and has been shown to likelihood of hormone-dependent including and prostate in several cohort and case-control studies as well as in animal experiments. In addition, strong mechanistic evidence has been reported at the cellular and molecular levels in this regard. Thus, in the monographs of carcinogenic hazards to humans, the International Agency for Research on Cancer (IARC) classified shift work that involves circadian disruption in Group 2A, ‘probably carcinogenic to humans’ consecutively in 2007 and in 2019. This review aims to enable a better understanding of the complex relationship between circadian sleep distribution and cancer risk and addresses some precautionary measures to limit the risk of carcinogenesis in populations working in night-shifts and/or exposed to LAN.
在昼夜节律中,睡眠中断是夜班和慢性人工夜间(LAN)的主要后果,并且在一些队列和病例对照研究以及动物实验中已显示出激素依赖性包括前列腺的可能性。此外,在细胞和分子水平上已经报道了这方面的强有力的机制证据。因此,国际癌症研究机构(IARC)在2007年和2019年连续将涉及昼夜节律中断的轮班工作分类为2A组“可能对人类致癌”。本综述旨在更好地理解昼夜睡眠分布与癌症风险之间的复杂关系,并提出一些预防措施,以限制夜班和/或暴露于LAN的人群的致癌风险。
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引用次数: 3
The Chronobiologic-Based Practical Approach to Shift Work 基于时间生物学的轮班工作实践方法
Pub Date : 2019-09-30 DOI: 10.33069/cim.2019.0013
Chul-Hyun Cho, Yujin Lee
With the rapid industrialization of modern society, people’s daily lives have changed. The invention of electricity has enabled the use of artificial light, which has consequently altered the industrial form and daily life [1]. The industrialization has increased both the types of occupations and the number of shifts available to workers. Shift work may be essential for security, infrastructure, and medical facilities, but in many cases, shift work is often done to increase productivity and convenience [2]. In Korea, approximately 10% of employees are shift workers. Among Korean shift workers, 50.4% work a rotating two-shift, 33.7% work a rotating three-shift, and 14.0% work a daily split shift [3]. Socioeconomic viewpoints can elucidate the necessity of shift work, though insufficient consideration and concern regarding the health effects on shift workers remain a prominent problem [4]. Shift workers may experience circadian rhythm disruption due to their shift work schedule; therefore, health impacts and consequences related to circadian rhythm disruptions should be seriously considered. Shift work can have both shortand long-term adverse health The Chronobiologic-Based Practical Approach to Shift Work
随着现代社会的快速工业化,人们的日常生活发生了变化。电的发明使人造光的使用成为可能,从而改变了工业形式和日常生活[1]。工业化增加了工人的职业种类和轮班次数。轮班工作可能对安全、基础设施和医疗设施至关重要,但在许多情况下,轮班工作通常是为了提高生产率和便利性[2]。在韩国,大约10%的员工是倒班工人。在韩国轮班工人中,50.4%的人是两班制,33.7%的人是三班制,14.0%的人是每日分班制[3]。社会经济观点可以阐明轮班工作的必要性,但对轮班工人健康影响的考虑和关注不足仍然是一个突出问题[4]。轮班工人可能会因为轮班工作而经历昼夜节律紊乱;因此,应认真考虑与昼夜节律中断有关的健康影响和后果。轮班工作对健康有短期和长期的不利影响。基于时间生物学的轮班工作实践方法
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引用次数: 8
Geriatric Sleep Medicine, a Young Field 老年睡眠医学,一个年轻的领域
Pub Date : 2019-09-30 DOI: 10.33069/cim.2019.0014
Lionel Soyeux
Geriatric Sleep Medicine, also known as sleep medicine of old age, is medical field dealing with the prevention, diagnosis and treatment of sleep disorders in older adults. From the 2000s, through the pioneering approach of the two physicians, Dr. S. Hakki Onen (University of Lyon, France) and Dr. Fannie Onen (University of Paris, France), Geriatric Sleep Medicine was structured as a new clinical sub-specialty. These visionaries opened first Geriatric Sleep Medicine Centers dedicated to the prevention, diagnosis and treatment of sleep disorders of older patients with medical comorbid conditions and disabilities. For about two decades these centers encompass patient care, research, and educational missions. In 2006, the French Ministry of Health released a report on sleep including a Geriatric Sleep Medicine section co-authored by Onen F and Onen SH [1]. It was highlighted that sleep disorders in older people are usually unrecognized and/or untreated, contributing to a wide range of deleterious health and safety consequences including sedative drug abuse, cognitive impairment, cardiovascular complications, post-operative hazards, falls/fractures and increased mortality. Consequently, authors called for increased awareness among healthcare professionals about the physiology of healthy sleep and sleep disorders in older adults and the development and implementation of education programs to promote the early diagnosis and appropriate treatment of sleep disorders. The SFRMS (French Sleep Society) supported this call by organizing special sessions on sleep disorders and aging during its annual meetings. Later, in 2009 the first and unique Geriatric Sleep Medicine School was created in both Universities Paris and Lyon deliverGeriatric Sleep Medicine, a Young Field
老年睡眠医学(Geriatric Sleep Medicine),又称老年睡眠医学,是研究老年人睡眠障碍的预防、诊断和治疗的医学领域。从2000年代开始,通过两位医生S. Hakki Onen博士(法国里昂大学)和Fannie Onen博士(法国巴黎大学)的开创性方法,老年睡眠医学被构建为一个新的临床亚专科。这些有远见的人开设了第一个老年睡眠医学中心,致力于预防、诊断和治疗患有合并症和残疾的老年患者的睡眠障碍。大约二十年来,这些中心包括病人护理、研究和教育任务。2006年,法国卫生部发布了一份关于睡眠的报告,其中包括由Onen F和Onen SH共同撰写的老年睡眠医学部分[1]。有人强调指出,老年人的睡眠障碍通常未被认识和(或)未经治疗,从而造成一系列有害的健康和安全后果,包括镇静剂滥用、认知障碍、心血管并发症、手术后危险、跌倒/骨折和死亡率增加。因此,作者呼吁医疗保健专业人员提高对老年人健康睡眠和睡眠障碍生理学的认识,并制定和实施教育计划,以促进睡眠障碍的早期诊断和适当治疗。SFRMS(法国睡眠学会)支持这一呼吁,在年会期间组织了关于睡眠障碍和衰老的特别会议。后来,在2009年,第一所也是唯一的老年睡眠医学院在巴黎大学和里昂大学成立,提供老年睡眠医学,一个年轻的领域
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引用次数: 1
The Role of Circadian Clocks in Metabolism 生物钟在新陈代谢中的作用
Pub Date : 2019-09-30 DOI: 10.33069/cim.2019.0017
K. Kim
Circadian rhythm refers to endogenous biological rhythm, which completes cyclic repetitions every 24 hours; the term originated from the Latin words circa, which means “around,” and dies, which means “day” [1,2]. Most organisms on the planet including human beings have evolved their own rhythmic programming of biological and behavioral outputs in response to these stimuli to maintain metabolic balance and promote survival [3,4]. Circadian rhythm helps our physiology to adapt to the environmental or behavioral changes in a time-of-day-dependent manner [5]. Beyond simply adapting to stimulus-response interaction, circadian rhythms are governed by an intrinsic molecular oscillator, the circadian clock [6]. Zeitgeber, literally meaning “time giver,” refers to any stimulus related to time cue from the external environment [1,6]. Our circadian clock constantly communicates with these zeitgebers to maintain circadian rhythm originally settled [1-6]. Without external stimulation, circadian clocks quite predictably control the daily timing of synthesis and release of most hormones [1,7]. In mammals, the circadian clock affects many aspects of the physiology including sleep-wake cycles, feeding-fasting cycles, and metabolic processes of the gastrointestinal tract, kidney, heart, and liver [8,9]. Previous epidemiological studies demonThe Role of Circadian Clocks in Metabolism
昼夜节律是指内源性生物节律,每24小时完成循环重复;这个词起源于拉丁语circa,意思是“周围”,dies意思是“一天”[1,2]。地球上的大多数生物,包括人类,都已经进化出了自己的生物和行为输出的节奏编程,以应对这些刺激,以维持代谢平衡,促进生存[3,4]。昼夜节律帮助我们的生理适应环境或行为变化,以一种依赖于时间的方式。除了简单地适应刺激-反应的相互作用,昼夜节律是由一个内在的分子振荡器,生物钟[6]控制的。授时因子(Zeitgeber),字面意思是“时间给予者”,是指来自外部环境的任何与时间线索相关的刺激[1,6]。我们的生物钟不断与这些授时因子沟通,以维持最初确定的昼夜节律[1-6]。在没有外界刺激的情况下,生物钟完全可以预测地控制大多数激素的合成和释放的每日时间[1,7]。在哺乳动物中,生物钟影响着生理的许多方面,包括睡眠-觉醒周期、摄食-禁食周期以及胃肠道、肾脏、心脏和肝脏的代谢过程[8,9]。先前的流行病学研究证实了生物钟在新陈代谢中的作用
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引用次数: 3
Depression and Anxiety Associated with Insomnia and Recent Stressful Life Events 抑郁和焦虑与失眠和最近的压力生活事件有关
Pub Date : 2019-09-30 DOI: 10.33069/cim.2019.0015
Chang Woo Lee, Sehyun Jeon, Jichul Kim, Bum Joon Seok, Seog-Ju Kim
Sleep and stress are closely related phenomenon. Various sleep disturbances, including insomnia, may develop after stressful experiences or under stressful circumstances [1]. Individuals with underlying sleep problems are more vulnerable to depression and anxiety after a stressful event than are those without sleep problems [2-5]. The recent concept of sleep reactivity [6] describes the degree to which a stressor disrupts sleep [7]. Individuals with high sleep reactivity are more vulnerable to sleep disturbances after stress. Sleep reactivity is a predictive factor for insomnia [8], and of the various and heterogeneous etiologies of insomnia, it is thought to be the main cause of transient and chronic insomnia [9]. Insomnia is closely associated with depression and anxiety [10]; it is a diagnostic criterion for major depressive disorder and generalized anxiety disorder [11-13], and people with insomnia have more severe depression and anxiety symptoms than normal sleepers [14]. Furthermore, people with insomnia are more likely to deDepression and Anxiety Associated with Insomnia and Recent Stressful Life Events
睡眠和压力是密切相关的现象。各种各样的睡眠障碍,包括失眠,可能在压力经历或压力环境下发生。与没有睡眠问题的人相比,有潜在睡眠问题的人在压力事件后更容易出现抑郁和焦虑[2-5]。最近的睡眠反应[6]概念描述了压力源干扰睡眠[7]的程度。睡眠反应性高的人在压力后更容易受到睡眠障碍的影响。睡眠反应性是失眠[8]的一个预测因素,在各种各样的失眠病因中,它被认为是短暂性和慢性失眠[8]的主要原因。失眠与抑郁和焦虑密切相关;它是重度抑郁症和广泛性焦虑症的诊断标准[11-13],失眠患者比正常睡眠者有更严重的抑郁和焦虑症状bbb。此外,患有失眠症的人更容易抑郁和焦虑,这与失眠和最近的压力生活事件有关
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引用次数: 4
Total Oxidant and Antioxidant Status in Patients with Obstructive Sleep Apnea and the Effect of Continuous Positive Airway Pressure 阻塞性睡眠呼吸暂停患者总氧化剂和抗氧化状态及持续气道正压通气的影响
Pub Date : 2019-09-30 DOI: 10.33069/cim.2019.0019
H. Kang, I. Kim, S. H. Lee
Obstructive sleep apnea (OSA) is a common disorder of middle-aged adults, affecting 4% of men and 2% of women [1]. The incidence of cardiovascular mortalities and morbidities such as hypertension, ischemic heart disease, arrhythmias, and stroke is higher in patients with OSA than in the general population [2]. OSA is characterized by recurrent upper airway obstruction. Patients with OSA experience intermittent hypoxia, leading to hypoxemia, hypercapnia, and increased sympathetic activation. Several studies have reported increased oxidative stress in patients with OSA [3-5]. Changes in blood oxygen saturation levels during sleep in OSA may result in the oxidant-antioxidant imbalance in favor of higher oxidants, depending on recurrent hypoxic events [6]. Increased generation of reactive oxygen species in vivo can lead to the depletion of one or more antioxidants, and the loss can be measured as an index of oxidative stress [7]. However, there are Total Oxidant and Antioxidant Status in Patients with Obstructive Sleep Apnea and the Effect of Continuous Positive Airway Pressure
阻塞性睡眠呼吸暂停(OSA)是中年成年人的一种常见疾病,影响了4%的男性和2%的女性。OSA患者的心血管疾病死亡率和发病率,如高血压、缺血性心脏病、心律失常和中风的发生率高于一般人群[10]。阻塞性睡眠呼吸暂停的特征是复发性上气道阻塞。OSA患者经历间歇性缺氧,导致低氧血症、高碳酸血症和交感神经激活增加。一些研究报道了OSA患者氧化应激升高[3-5]。阻塞性睡眠呼吸暂停患者睡眠期间血氧饱和度水平的变化可能导致氧化-抗氧化失衡,有利于较高的氧化剂,这取决于反复出现的缺氧事件bbb。体内活性氧生成的增加可导致一种或多种抗氧化剂的消耗,这种损失可以作为氧化应激的一个指标来测量。然而,阻塞性睡眠呼吸暂停患者存在总氧化剂和抗氧化状态以及持续气道正压通气的影响
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引用次数: 3
Circadian Gene Variations Are Associated with Obsessive-Compulsive Behaviors in a Young Healthy Korean Population 在年轻健康的韩国人群中,昼夜节律基因变异与强迫症行为有关
Pub Date : 2019-09-30 DOI: 10.33069/cim.2019.0020
Jaegwon Jeong, Yujin Lee, C. Cho, Heon-Jeong Lee
Recently, growing evidence implies that circadian rhythm may influence and/or play a central role in psychiatric disorders, such as bipolar disorder [1,2], schizophrenia [3], and autism [4]. However, there is limited knowledge on the role of circadian rhythms in obsessive-compulsive disorder (OCD). Disruption of circadian regulation of body temperature and hormonal levels has been observed in those with OCD [5-7]. Difference in sleep behavior (i.e., reduced total sleep time, increased awakening after sleep onset, extended sleep onset latency) and in sleep architecture [i.e., decreased latency to the onset of rapid eye movement (REM) sleep and increased density of REM sleep] have been reported in OCD patients compared to healthy individuals [8-12]. Delayed bedtimes are also associated with increased OC symptoms [13]. Delayed sleep phase disorder is known to be more prevalent in severe OCD patients [14,15]. Seasonal affective Circadian Gene Variations Are Associated with Obsessive-Compulsive Behaviors in a Young Healthy Korean Population
最近,越来越多的证据表明,昼夜节律可能影响和/或在精神疾病中发挥核心作用,如双相情感障碍[1,2]、精神分裂症[3]和自闭症[4]。然而,关于昼夜节律在强迫症(OCD)中的作用的知识有限。在强迫症患者中已经观察到体温和激素水平的昼夜节律调节被破坏[5-7]。据报道,与健康个体相比,强迫症患者在睡眠行为(即总睡眠时间减少、睡眠开始后觉醒增加、睡眠开始潜伏期延长)和睡眠结构(即快速眼动(REM)睡眠开始潜伏期减少和快速眼动睡眠密度增加)方面存在差异[8-12]。延迟就寝时间也与OC症状增加有关[13]。已知延迟睡眠阶段障碍在严重强迫症患者中更为普遍[14,15]。在年轻健康的韩国人群中,季节性情感昼夜节律基因变异与强迫症行为有关
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引用次数: 3
Light and Life at Night as Circadian Rhythm Disruptors 昼夜节律破坏者夜间的光和生命
Pub Date : 2019-09-30 DOI: 10.33069/cim.2019.0016
Eunil Lee, Mari Kim
The axial rotation of the Earth, together with the light of the sun, generates 24-hour cycles of day and night, and this light-dark cycle is the basis of 24-hour circadian rhythms. Living organisms have their own endogenous circadian rhythms, also with a duration of approximately 24 hours, driven by environmental factors, especially light and darkness [1]. And it is widely known that circadian rhythms of mammals are regulated by an internal biological clock located in the suprachiasmatic nuclei (SCN) situated directly above the optic chiasm [2]. Maintaining the biological clock is crucial for coordinated function throughout the human body because this near-24-hour oscillations are found in essentially every physiological process in the human brain and body [3,4]. The period, phase and amplitude of circadian rhythms can be affected by circadian gene variants, light exposure, social cues, meal times and work schedules [5-8]. Light is the most effective Light and Life at Night as Circadian Rhythm Disruptors
地球的轴向旋转,加上太阳的光,产生了24小时的昼夜循环,这种明暗循环是24小时昼夜节律的基础。生物有自己的内源性昼夜节律,其持续时间也在24小时左右,受环境因素的驱动,尤其是光照和黑暗[1]。众所周知,哺乳动物的昼夜节律是由位于视交叉正上方的视交叉上核(suprachiasmatic nucleus, SCN)的内部生物钟调节的[2]。维持生物钟对于整个人体的协调功能至关重要,因为这种近24小时的振荡基本上存在于人类大脑和身体的每一个生理过程中[3,4]。昼夜节律的周期、相位和幅度可受到昼夜节律基因变异、光照、社交线索、用餐时间和工作时间表的影响[5-8]。光是最有效的光和生命在夜间昼夜节律的破坏者
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引用次数: 10
Zolpidem-Induced Sleep-Related Eating Disorder 唑吡坦引起的睡眠相关进食障碍
Pub Date : 2019-09-30 DOI: 10.33069/cim.2019.0018
Young-Min Park
SRED and night eating syndrome (NES) have nocturnal eating in common with the following characteristics: [2] 1) primarily occurring at night, 2) often being accompanied by insomnia, and 3) being associated with sleep disorders. Hunger and sleep are basic biological desires that are both affected by homeostasis and the circadian cycle [3]. Patients either do not remember at all or reZolpidem-Induced Sleep-Related Eating Disorder
SRED和夜间进食综合征(NES)在夜间进食有以下共同特征:[2]1)主要发生在夜间,2)常伴有失眠,3)与睡眠障碍有关。饥饿和睡眠是基本的生理需求,它们都受到体内平衡和昼夜周期的影响。患者要么完全不记得,要么是瑞唑吡坦诱发的睡眠相关进食障碍
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引用次数: 0
Insomnia and Depressive Symptoms in Adolescents: Can Cognitive Behavioral Therapy for Insomnia Contribute to Improve Adolescents’ Depressive Symptoms? 青少年失眠与抑郁症状:失眠的认知行为疗法是否有助于改善青少年抑郁症状?
Pub Date : 2019-06-30 DOI: 10.33069/CIM.2019.0003
Weidong Song, Xiaohui Hu, B. Fan, Cai-Feng Gao, Mengshi Qiu, Jihui Zhang
Epidemiology of insomnia in adolescents Insomnia symptoms are prevalent in both adults and children [1-4]. Female sex [4], low socioeconomic status [2], stressful life events [2], and poor general and mental health [5] are commonly identified risk factors. In particular, female sex is a consistent risk factor for insomnia in adult and elderly populations in terms of the higher prevalence, more persistent natural course [6], and more serious health-related repercussions [7]. For example, stronger impacts of insomnia symptoms on pain perception [8], increased cortisol awakening response [9], and resistant hypertension [10] were found in adult females when compared with adult males. Interestingly, most studies did not find any sex differences in insomnia in children [1,5,6]. Thus, puberty has been postulated as a critical stage for the development of insomnia and the emergence Insomnia and Depressive Symptoms in Adolescents: Can Cognitive Behavioral Therapy for Insomnia Contribute to Improve Adolescents’ Depressive Symptoms?
青少年失眠的流行病学失眠症状在成人和儿童中都很普遍[1-4]。女性性别[4],低社会经济地位[2],生活压力[2],一般和心理健康状况不佳[5]是常见的危险因素。特别是,女性是成年人和老年人失眠的一贯危险因素,其患病率更高,自然病程更持久,健康影响更严重。例如,与成年男性相比,失眠症状对成年女性疼痛感知[8]、皮质醇觉醒反应[9]和顽固性高血压[10]的影响更强。有趣的是,大多数研究并未发现儿童失眠的性别差异[1,5,6]。因此,青春期被认为是青少年失眠发展和出现失眠和抑郁症状的关键阶段:失眠的认知行为疗法是否有助于改善青少年抑郁症状?
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引用次数: 2
期刊
Chronobiology in Medicine
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