Nuree Kang, Cheol-Soon Lee, B. Cha, So-Jin Lee, Dongyun Lee, Jiyeong Seo, Jae-Won Choi, Young-Ji Lee, Eunji Lim, B. Kim
Objective: Internet addiction and smartphone addiction are emerging mental health concerns in adolescents. To determine the factors related to these conditions, we investigated their associations with sleep quality, chronotype, sleep patterns, daylight exposure, depression, and anxiety.Methods: Self-rated questionnaires, including the Internet Addiction Proneness Scale-Short Form, Smartphone Addiction Scale–short version, Insomnia Severity Index, Morningness–Eveningness Questionnaire, Epworth Sleepiness Scale, sleep-related questionnaires, and Hospital Anxiety and Depression Scale, were administered in a study population of 1,610 Korean high school students. Multiple linear regression analyses were performed to evaluate the associations with internet addiction and smartphone addiction.Results: Multiple linear regression showed significant associations of internet addiction with poor sleep quality (β=0.094, p<0.001), eveningness (β=-0.071, p=0.006), less daylight exposure (β=-0.066, p=0.005), anxiety (β=0.252, p<0.001), and older age (β=0.295, p<0.001). Smartphone addiction was significantly associated with poor sleep quality (β=0.076, p=0.005), eveningness (β=-0.164, p<0.001), excessive daytime sleepiness (β=0.109, p<0.001), longer time in bed on weekdays (β=0.057, p=0.024), shorter weekend oversleep (β=-0.081, p=0.005), anxiety (β=0.192, p<0.001), and younger age (β=-0.145, p<0.001).Conclusion: Our findings suggest that poor sleep quality, eveningness, and anxiety can serve as predictors of both internet addiction and smartphone addiction in adolescents. Internet addiction seems to be negatively associated with daylight exposure, whereas smartphone addiction showed significant associations with sleep patterns. Additional studies regarding the causal relations between these factors are needed.
{"title":"Poor Sleep Quality, Eveningness, and Anxiety Are Associated With Internet/Smartphone Addiction in Korean Adolescents","authors":"Nuree Kang, Cheol-Soon Lee, B. Cha, So-Jin Lee, Dongyun Lee, Jiyeong Seo, Jae-Won Choi, Young-Ji Lee, Eunji Lim, B. Kim","doi":"10.33069/cim.2022.0019","DOIUrl":"https://doi.org/10.33069/cim.2022.0019","url":null,"abstract":"Objective: Internet addiction and smartphone addiction are emerging mental health concerns in adolescents. To determine the factors related to these conditions, we investigated their associations with sleep quality, chronotype, sleep patterns, daylight exposure, depression, and anxiety.Methods: Self-rated questionnaires, including the Internet Addiction Proneness Scale-Short Form, Smartphone Addiction Scale–short version, Insomnia Severity Index, Morningness–Eveningness Questionnaire, Epworth Sleepiness Scale, sleep-related questionnaires, and Hospital Anxiety and Depression Scale, were administered in a study population of 1,610 Korean high school students. Multiple linear regression analyses were performed to evaluate the associations with internet addiction and smartphone addiction.Results: Multiple linear regression showed significant associations of internet addiction with poor sleep quality (β=0.094, p<0.001), eveningness (β=-0.071, p=0.006), less daylight exposure (β=-0.066, p=0.005), anxiety (β=0.252, p<0.001), and older age (β=0.295, p<0.001). Smartphone addiction was significantly associated with poor sleep quality (β=0.076, p=0.005), eveningness (β=-0.164, p<0.001), excessive daytime sleepiness (β=0.109, p<0.001), longer time in bed on weekdays (β=0.057, p=0.024), shorter weekend oversleep (β=-0.081, p=0.005), anxiety (β=0.192, p<0.001), and younger age (β=-0.145, p<0.001).Conclusion: Our findings suggest that poor sleep quality, eveningness, and anxiety can serve as predictors of both internet addiction and smartphone addiction in adolescents. Internet addiction seems to be negatively associated with daylight exposure, whereas smartphone addiction showed significant associations with sleep patterns. Additional studies regarding the causal relations between these factors are needed.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116422263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to examine clinical characteristics and to identify possible risk factors of sleep disturbances in people living with HIV (PLWH).Methods: All research data of patients who were first diagnosed with HIV/AIDS from January 1, 2012 to December 31, 2021 and complained of sleep disturbance at least once were retrospectively reviewed by the Severance Clinical Research Analysis Portal (SCRAP) service of Severance hospital. The presence of sleep disturbance was evaluated based on whether insomnia disorder diagnosis code was included or whether insomnia medication was prescribed. The patients were divided into either the group with sleep disturbance within 3 months (SDW3) and the group with after 3 months (SDA3). All data were reported using descriptive statistics.Results: Of the 674 patients diagnosed with HIV during the period, 56 patients experienced sleep disturbances at least once and approximately 50% of patients have experienced sleep disturbance in the first 3 months after HIV diagnosis. CD4+ cell count at the time of first onset of sleep disturbance was significantly lower (p=0.03) and HIV viral load at the time of first onset of sleep disturbance was significantly higher (p<0.001) in SDW3 group. SDW3 patients showed higher rates of opportunistic infections compared to SDA3 patients.Conclusion: The current study suggests that further investigation of the underlying pathophysiology of sleep disturbance and association with immunological changes for early diagnosis and treatment of sleep disturbance in PLWH.
{"title":"Clinical Characteristics of HIV-Infected Patients With Sleep Disturbance","authors":"Suonaa Lee, K. Park, W. J. Kim, Eun Lee","doi":"10.33069/cim.2022.0020","DOIUrl":"https://doi.org/10.33069/cim.2022.0020","url":null,"abstract":"Objective: This study aims to examine clinical characteristics and to identify possible risk factors of sleep disturbances in people living with HIV (PLWH).Methods: All research data of patients who were first diagnosed with HIV/AIDS from January 1, 2012 to December 31, 2021 and complained of sleep disturbance at least once were retrospectively reviewed by the Severance Clinical Research Analysis Portal (SCRAP) service of Severance hospital. The presence of sleep disturbance was evaluated based on whether insomnia disorder diagnosis code was included or whether insomnia medication was prescribed. The patients were divided into either the group with sleep disturbance within 3 months (SDW3) and the group with after 3 months (SDA3). All data were reported using descriptive statistics.Results: Of the 674 patients diagnosed with HIV during the period, 56 patients experienced sleep disturbances at least once and approximately 50% of patients have experienced sleep disturbance in the first 3 months after HIV diagnosis. CD4+ cell count at the time of first onset of sleep disturbance was significantly lower (p=0.03) and HIV viral load at the time of first onset of sleep disturbance was significantly higher (p<0.001) in SDW3 group. SDW3 patients showed higher rates of opportunistic infections compared to SDA3 patients.Conclusion: The current study suggests that further investigation of the underlying pathophysiology of sleep disturbance and association with immunological changes for early diagnosis and treatment of sleep disturbance in PLWH.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127675921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The coronavirus disease 2019 (COVID-19) pandemic has caused major psychological distress, mental health problems, sleep disturbances, anxiety, and depression. Among them, obstructive sleep apnea (OSA) is known as a comorbidity of diabetes, cardiovascular disease, asthma, obesity, high blood pressure, and chronic obstructive pulmonary disease, and these are poor prognostic factors for COVID-19 morbidity. Therefore, it is important to properly diagnose and treat sleep apnea during the COVID-19 pandemic. Due to the pandemic of COVID-19, in-lab sleep studies such as polysomnography (PSG) tend to slightly decrease, and alternative methods such as home sleep apnea tests (HSAT) and telemedicine tend to emerge relatively. In the post-COVID-19 era, HSAT with a technically adequate device and telemedicine may become an important modality for the diagnosis and treatment of OSA. In addition, the protection of PSG technicians and the disinfection of equipment and the environment of in-lab sleep studies are emphasized. If COVID-19 is ruled out, the use of positive airway pressure devices for therapeutic purposes is not restricted, but efforts should be made to minimize the risk of aerosol generation. Infection and quality control in PSG are important and inevitable issues, and regulation within each institution will be required during and after the COVID-19 pandemic.
{"title":"Impact of COVID-19 on Obstructive Sleep Apnea","authors":"J. Park, K. Lee, S. Hong","doi":"10.33069/cim.2022.0023","DOIUrl":"https://doi.org/10.33069/cim.2022.0023","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) pandemic has caused major psychological distress, mental health problems, sleep disturbances, anxiety, and depression. Among them, obstructive sleep apnea (OSA) is known as a comorbidity of diabetes, cardiovascular disease, asthma, obesity, high blood pressure, and chronic obstructive pulmonary disease, and these are poor prognostic factors for COVID-19 morbidity. Therefore, it is important to properly diagnose and treat sleep apnea during the COVID-19 pandemic. Due to the pandemic of COVID-19, in-lab sleep studies such as polysomnography (PSG) tend to slightly decrease, and alternative methods such as home sleep apnea tests (HSAT) and telemedicine tend to emerge relatively. In the post-COVID-19 era, HSAT with a technically adequate device and telemedicine may become an important modality for the diagnosis and treatment of OSA. In addition, the protection of PSG technicians and the disinfection of equipment and the environment of in-lab sleep studies are emphasized. If COVID-19 is ruled out, the use of positive airway pressure devices for therapeutic purposes is not restricted, but efforts should be made to minimize the risk of aerosol generation. Infection and quality control in PSG are important and inevitable issues, and regulation within each institution will be required during and after the COVID-19 pandemic.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125585600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joo Hyung Ryu, J. Yeom, Jae Eun Seo, C. Cho, Heon-Jeong Lee
Objective: Seasonal variations in mood and behavior and diurnal preference are associated with several genes that regulate circadian rhythms. In this study, we investigated the association of the NPAS2 rs6725296 polymorphism with seasonality and diurnal preference.Methods: A total of 510 healthy subjects were genotyped for the NPAS2 rs6725296 polymorphism and completed self-report questionnaires on seasonality and diurnal preferences. Seasonality was evaluated using the seasonal pattern assessment questionnaire, and diurnal preference was evaluated using the Composite Scale of Morningness (CSM). We assessed the association of genotype and allele carrier status with the total and subscale scores of global seasonality scores (GSS) for seasonality and the total and subscale scores of CSM for diurnal preference.Results: No significant associations were found between the NPAS2 rs6725296 genotype and the allele carrier status and the GSS and CSM scores.Conclusion: The results of this study suggest that the NPAS2 rs6725296 polymorphism may not contribute to seasonality and diurnal preference in healthy Koreans. More studies with a larger number of subjects, inclusion of different ethnic groups, and complementation with objective measurements of seasonality and diurnal preference are necessary to evaluate the influence of genetics on seasonality and diurnal preference.
{"title":"No Association Between NPAS2 rs6425296 Polymorphism and Seasonality, Diurnal Preference in Koreans","authors":"Joo Hyung Ryu, J. Yeom, Jae Eun Seo, C. Cho, Heon-Jeong Lee","doi":"10.33069/cim.2022.0022","DOIUrl":"https://doi.org/10.33069/cim.2022.0022","url":null,"abstract":"Objective: Seasonal variations in mood and behavior and diurnal preference are associated with several genes that regulate circadian rhythms. In this study, we investigated the association of the NPAS2 rs6725296 polymorphism with seasonality and diurnal preference.Methods: A total of 510 healthy subjects were genotyped for the NPAS2 rs6725296 polymorphism and completed self-report questionnaires on seasonality and diurnal preferences. Seasonality was evaluated using the seasonal pattern assessment questionnaire, and diurnal preference was evaluated using the Composite Scale of Morningness (CSM). We assessed the association of genotype and allele carrier status with the total and subscale scores of global seasonality scores (GSS) for seasonality and the total and subscale scores of CSM for diurnal preference.Results: No significant associations were found between the NPAS2 rs6725296 genotype and the allele carrier status and the GSS and CSM scores.Conclusion: The results of this study suggest that the NPAS2 rs6725296 polymorphism may not contribute to seasonality and diurnal preference in healthy Koreans. More studies with a larger number of subjects, inclusion of different ethnic groups, and complementation with objective measurements of seasonality and diurnal preference are necessary to evaluate the influence of genetics on seasonality and diurnal preference.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131817734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Circadian rhythms are present almost in all living organisms and synchronized with the zeitgebers (time givers), especially lightdark (LD) cycles. The jetlag and rotating shift work schedules lead to desynchronization of the circadian clock with zeitgebers which may cause various health problems. Studies have shown that withanolide-A (WA) is a potent nootropic and neuroprotective agent found in Withania somnifera. Thus, the objective was to study the effect of WA on the circadian locomotor activity rhythm following the phase inversion of 12:12 h LD cycle in mice and its impact on the spatial memory in mice.Methods: Adult male mice were housed in the chronocubicle and recorded circadian locomotor activity rhythm by using ClockLab setup. The experimental mice were administered with WA (10 μmol/kg/day) for 13 consecutive days at about ZT15 and then evoked an acute phase inversion of 12:12 h light-dark cycle. Further, the Barnes maze test was performed to check the effect of WA on spatial memory following the phase inversion.Results: The results showed that WA-treated group took significantly fewer transient cycles (4.66+0.66) for re-entrainment than the control (9.5+0.43) and vehicle-treated (8.33+1.28) mice following the phase inversion. Similarly, WA-treated mice traveled less distance to reach the target zone in the Barnes maze compared to vehicle and control groups.Conclusion: These results suggest that the WA may act as chronobiotic and neuroprotective agent since it decreased the transient cycles for re-entrainment and retaining spatial memory following the phase inversion.
目的:昼夜节律几乎存在于所有生物体中，并与授时因子(时间给予者)同步，特别是光暗(LD)周期。时差和轮班工作安排导致生物钟与授时基因不同步，这可能会导致各种健康问题。研究表明，Withania somnifera中的withanolide-A (WA)是一种有效的益智剂和神经保护剂。因此，我们的目的是研究WA对小鼠12:12 h LD周期相位反转后的昼夜运动活动节律的影响及其对小鼠空间记忆的影响。方法:将成年雄性小鼠置于定时隔间内，利用ClockLab装置记录小鼠的昼夜运动活动节律。实验小鼠在ZT15左右连续13天给予WA (10 μmol/kg/天)，引起急性期反转，为12:12 h的明暗循环。通过Barnes迷宫实验验证了脑电对空间记忆的影响。结果:与对照组(9.5+0.43)和载药组(8.33+1.28)相比，wa处理组(4.66+0.66)的再夹带周期明显缩短。同样，在巴恩斯迷宫中，与车辆组和对照组相比，wa治疗的小鼠到达目标区域的距离更短。结论:脑白质具有时间生成剂和神经保护剂的作用，可减少脑相转后空间记忆的恢复和空间记忆的短暂周期。
{"title":"Withanolide-A Accelerates Re-entrainment of Circadian Locomotor Activity Rhythm and Preserves Spatial Memory in Mice Following Acute Phase Inversion of Light-Dark Cycles","authors":"Trisha Tiwari, P. Basu, M. Singaravel","doi":"10.33069/cim.2022.0018","DOIUrl":"https://doi.org/10.33069/cim.2022.0018","url":null,"abstract":"Objective: Circadian rhythms are present almost in all living organisms and synchronized with the zeitgebers (time givers), especially lightdark (LD) cycles. The jetlag and rotating shift work schedules lead to desynchronization of the circadian clock with zeitgebers which may cause various health problems. Studies have shown that withanolide-A (WA) is a potent nootropic and neuroprotective agent found in Withania somnifera. Thus, the objective was to study the effect of WA on the circadian locomotor activity rhythm following the phase inversion of 12:12 h LD cycle in mice and its impact on the spatial memory in mice.Methods: Adult male mice were housed in the chronocubicle and recorded circadian locomotor activity rhythm by using ClockLab setup. The experimental mice were administered with WA (10 μmol/kg/day) for 13 consecutive days at about ZT15 and then evoked an acute phase inversion of 12:12 h light-dark cycle. Further, the Barnes maze test was performed to check the effect of WA on spatial memory following the phase inversion.Results: The results showed that WA-treated group took significantly fewer transient cycles (4.66+0.66) for re-entrainment than the control (9.5+0.43) and vehicle-treated (8.33+1.28) mice following the phase inversion. Similarly, WA-treated mice traveled less distance to reach the target zone in the Barnes maze compared to vehicle and control groups.Conclusion: These results suggest that the WA may act as chronobiotic and neuroprotective agent since it decreased the transient cycles for re-entrainment and retaining spatial memory following the phase inversion.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123471071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Modern humans are experiencing more disturbances in biological rhythms than in human history. The biological rhythm of modern humans is assumed to be quite different from that of our ancestors in the past. This phenomenon is due to the disturbances in the biological rhythm caused by artificial light and the lifestyle patterns adopted by us. Therefore, it is crucial to investigate the influence of circadian rhythm disturbances on human health. Recently, several interesting papers have shown that circadian rhythms are important for human health; a recently published paper particularly requires attention [1]. Eating and sleeping are two essential behaviors that humans engage in, on a daily basis [2]. Caloric restriction is known as one of the ways to live a long life. Several studies and experiments have shown that eating less increases the lifespan of animals by reducing the rate of aging. Reducing calorie intake reduces weight, in addition to lowering blood pressure and inflammation levels, and also regulates blood sugar in a better manner [3]. Furthermore, another study added that along with the amount of food eaten, the timing at which it is eaten is also important for extending the life span. Acosta-Rodríguez et al. [1] reported that a four-year experiment on hundreds of mice showed that eating only during active hours of the day contributes to an increase in life expectancy. The researchers examined these mice by dividing them into six groups and used an automatic feeder to control the amount of food and meal times. One group allowed them to eat as much as they wanted, while the other five groups were given 30%–40% Unraveling the Significance of Circadian Rhythms for Health
{"title":"Unraveling the Significance of Circadian Rhythms for Health","authors":"Heon-Jeong Lee","doi":"10.33069/cim.2022.0025","DOIUrl":"https://doi.org/10.33069/cim.2022.0025","url":null,"abstract":"Modern humans are experiencing more disturbances in biological rhythms than in human history. The biological rhythm of modern humans is assumed to be quite different from that of our ancestors in the past. This phenomenon is due to the disturbances in the biological rhythm caused by artificial light and the lifestyle patterns adopted by us. Therefore, it is crucial to investigate the influence of circadian rhythm disturbances on human health. Recently, several interesting papers have shown that circadian rhythms are important for human health; a recently published paper particularly requires attention [1]. Eating and sleeping are two essential behaviors that humans engage in, on a daily basis [2]. Caloric restriction is known as one of the ways to live a long life. Several studies and experiments have shown that eating less increases the lifespan of animals by reducing the rate of aging. Reducing calorie intake reduces weight, in addition to lowering blood pressure and inflammation levels, and also regulates blood sugar in a better manner [3]. Furthermore, another study added that along with the amount of food eaten, the timing at which it is eaten is also important for extending the life span. Acosta-Rodríguez et al. [1] reported that a four-year experiment on hundreds of mice showed that eating only during active hours of the day contributes to an increase in life expectancy. The researchers examined these mice by dividing them into six groups and used an automatic feeder to control the amount of food and meal times. One group allowed them to eat as much as they wanted, while the other five groups were given 30%–40% Unraveling the Significance of Circadian Rhythms for Health","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122244570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is Insomnia a Brain Disorder Arising From Aberrant Brain Structure, Brain Function, or Both?","authors":"Yu Jin Lee","doi":"10.33069/cim.2022.0014","DOIUrl":"https://doi.org/10.33069/cim.2022.0014","url":null,"abstract":"","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122794887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frailty is a geriatric syndrome with increased risk for poor health outcomes, including falls, cognitive impairment, hospitalization, and mortality. In previous studies, associations between frailty and sleep-related factors or sleep disorders have been investigated. We examined the relationship between frailty and insomnia, which are both common condition in older adults. Hormonal changes with aging and/or lifestyle changes all affect sleep physiology, which are vulnerable to the risk of insomnia. As the severity of frailty decreases the quality of sleep, and the long/short sleep duration is related to the risk of frailty, it can be assumed that frailty and sleep are reciprocally related. The association between frailty and insomnia has been variously proven in epidemiological studies conducted around the world. A close evaluation of insomnia and frailty in older adults provides a basis for improving the health of people in the aged society. There are few related studies in Korea, and in the future, not only basic epidemiological studies but also studies explaining the psychoneuroendocrinological mechanism of the relationship between insomnia and frailty should be performed together.
{"title":"Frailty and Insomnia in Older Adults","authors":"W. J. Kim, K. Park, Eun Lee","doi":"10.33069/cim.2022.0013","DOIUrl":"https://doi.org/10.33069/cim.2022.0013","url":null,"abstract":"Frailty is a geriatric syndrome with increased risk for poor health outcomes, including falls, cognitive impairment, hospitalization, and mortality. In previous studies, associations between frailty and sleep-related factors or sleep disorders have been investigated. We examined the relationship between frailty and insomnia, which are both common condition in older adults. Hormonal changes with aging and/or lifestyle changes all affect sleep physiology, which are vulnerable to the risk of insomnia. As the severity of frailty decreases the quality of sleep, and the long/short sleep duration is related to the risk of frailty, it can be assumed that frailty and sleep are reciprocally related. The association between frailty and insomnia has been variously proven in epidemiological studies conducted around the world. A close evaluation of insomnia and frailty in older adults provides a basis for improving the health of people in the aged society. There are few related studies in Korea, and in the future, not only basic epidemiological studies but also studies explaining the psychoneuroendocrinological mechanism of the relationship between insomnia and frailty should be performed together.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"11 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133141798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Chronotype and impulsivity are important features to be examined in mood disorder patients; these characteristics precede mood disorder onset and persist between mood episodes. Moreover, quality of life is an important outcome in psychiatric patients. This study investigated the interaction between these features and its effect on mood disorder patient’s quality of life.Methods: Early-onset major depressive disorder (MDD), bipolar disorder I (BD I), and bipolar disorder II (BD II) patients were recruited. Excluding 18 patients who were missing data on main variables and 5 patients who were classified as severely ill, a total of 472 euthymic patients (MDD=167, BD I=133, BD II= 172) were assessed on their chronotype, trait impulsivity, and quality of life using self-reports.Results: Both impulsivity and eveningness were negatively associated with quality of life. Regression results showed that there was a significant interaction effect between eveningness and impulsivity on quality of life. This indicates that the higher the level of impulsivity in mood disorder patients, the negative effect of eveningness on quality of life increased.Conclusion: The current study suggests that examination of impulsive personality in relation to chronotype may be important in further understanding the effects of these features on mood disorder patients’ lives.
{"title":"Eveningness and Impulsivity in Euthymic Mood States Adversely Affect the Quality of Life of Major Depression and Bipolar Disorder Patients","authors":"Sojeong Kim, Yeaseul Yoon, Heon-Jeong Lee","doi":"10.33069/cim.2022.0016","DOIUrl":"https://doi.org/10.33069/cim.2022.0016","url":null,"abstract":"Objective: Chronotype and impulsivity are important features to be examined in mood disorder patients; these characteristics precede mood disorder onset and persist between mood episodes. Moreover, quality of life is an important outcome in psychiatric patients. This study investigated the interaction between these features and its effect on mood disorder patient’s quality of life.Methods: Early-onset major depressive disorder (MDD), bipolar disorder I (BD I), and bipolar disorder II (BD II) patients were recruited. Excluding 18 patients who were missing data on main variables and 5 patients who were classified as severely ill, a total of 472 euthymic patients (MDD=167, BD I=133, BD II= 172) were assessed on their chronotype, trait impulsivity, and quality of life using self-reports.Results: Both impulsivity and eveningness were negatively associated with quality of life. Regression results showed that there was a significant interaction effect between eveningness and impulsivity on quality of life. This indicates that the higher the level of impulsivity in mood disorder patients, the negative effect of eveningness on quality of life increased.Conclusion: The current study suggests that examination of impulsive personality in relation to chronotype may be important in further understanding the effects of these features on mood disorder patients’ lives.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116394827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Hayrapetyan, L. Babayan, H. Danoyan, H. A. Vardanyan, Z. Petrosyan, Jon Karapetyan, Jon Karapetyan, A. K. Gulyan, P. K. Sarafyan, Ani R. Tavaracyan, A. B. Danoyan
The impact of variation in the geomagnetic field and a weather factors on the human body remains the subject of studies across the world, yet there is no consensus. Temporal organization and dynamics of bio-fluctuations evolved in the process of evolution under the influence of enviSeasonal Factors of Adaptation of Water-Mineral Chronoperiodical System in Healthy Individuals and Patients With Syndrome of Vegetative Dystonia
{"title":"Seasonal Factors of Adaptation of Water-Mineral Chronoperiodical System in Healthy Individuals and Patients With Syndrome of Vegetative Dystonia","authors":"H. Hayrapetyan, L. Babayan, H. Danoyan, H. A. Vardanyan, Z. Petrosyan, Jon Karapetyan, Jon Karapetyan, A. K. Gulyan, P. K. Sarafyan, Ani R. Tavaracyan, A. B. Danoyan","doi":"10.33069/cim.2022.0011","DOIUrl":"https://doi.org/10.33069/cim.2022.0011","url":null,"abstract":"The impact of variation in the geomagnetic field and a weather factors on the human body remains the subject of studies across the world, yet there is no consensus. Temporal organization and dynamics of bio-fluctuations evolved in the process of evolution under the influence of enviSeasonal Factors of Adaptation of Water-Mineral Chronoperiodical System in Healthy Individuals and Patients With Syndrome of Vegetative Dystonia","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133821884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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