Because of its specific method of action, such as antagonism of histamine H1 and serotonin type 2A receptors, quetiapine has a sedative effect.1 Quetiapine is chosen as a therapeutic alternative for treating individuals with schizophrenia or bipolar disorder who require sedation among other antipsychotics because of its sedative properties. In therapeutic practice, quetiapine is used to treat insomnia in people suffering from a variety of psychiatric conditions. Lee et al.2 looked at clinical data from Korea and reported on the prescription status of quetiapine for insomnia treatment. Quetiapine is commonly used to treat a variety of mental conditions, including schizophrenia, bipolar disorder, depression, and insomnia. Quetiapine is the favored therapeutic approach for treating primary insomnia in the elderly, according to reports. When atypical antipsychotics like quetiapine are used to treat insomnia symptoms in actual clinical settings, they are chosen for various concomitant therapeutic goals in addition to insomnia.3 According to the findings from the study reported by Lee et al.,2 quetiapine is recommended for treating insomnia in the elderly not only because of the vulnerability and risk of side effects associated with sedative-hypnotics, but also because of its sedative action. In the elderly, the administration of sedative-hypnotics may raise the risk of dementia or delirium and may result in long-term use, which is problematic. For the elderly who suffer from insomnia, non-pharmacological treatment options such as cognitive-behavioral therapy or light therapy may be a viable choice. However, there is a populaQuetiapine as a Potential Treatment for Insomnia: The Road Ahead
{"title":"Quetiapine as a Potential Treatment for Insomnia: The Road Ahead","authors":"C. Cho","doi":"10.33069/cim.2022.0010","DOIUrl":"https://doi.org/10.33069/cim.2022.0010","url":null,"abstract":"Because of its specific method of action, such as antagonism of histamine H1 and serotonin type 2A receptors, quetiapine has a sedative effect.1 Quetiapine is chosen as a therapeutic alternative for treating individuals with schizophrenia or bipolar disorder who require sedation among other antipsychotics because of its sedative properties. In therapeutic practice, quetiapine is used to treat insomnia in people suffering from a variety of psychiatric conditions. Lee et al.2 looked at clinical data from Korea and reported on the prescription status of quetiapine for insomnia treatment. Quetiapine is commonly used to treat a variety of mental conditions, including schizophrenia, bipolar disorder, depression, and insomnia. Quetiapine is the favored therapeutic approach for treating primary insomnia in the elderly, according to reports. When atypical antipsychotics like quetiapine are used to treat insomnia symptoms in actual clinical settings, they are chosen for various concomitant therapeutic goals in addition to insomnia.3 According to the findings from the study reported by Lee et al.,2 quetiapine is recommended for treating insomnia in the elderly not only because of the vulnerability and risk of side effects associated with sedative-hypnotics, but also because of its sedative action. In the elderly, the administration of sedative-hypnotics may raise the risk of dementia or delirium and may result in long-term use, which is problematic. For the elderly who suffer from insomnia, non-pharmacological treatment options such as cognitive-behavioral therapy or light therapy may be a viable choice. However, there is a populaQuetiapine as a Potential Treatment for Insomnia: The Road Ahead","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"31 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120914320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by chronic respiratory symptoms, structural pulmonary abnormalities, and airflow limitation [1]. COPD is highly common and is the third leading cause of death worldwide [2]. Sleep disturbance is one of the most common complaints in patients with COPD, and the presence of sleep disorders further deteriorates their quality of life [3]. Symptom exacerbations are associated with poor sleep quality in patients with COPD [4]. Patients with COPD experience sleep fragmentation with frequent arousals, reduced slow-wave, rapid eye movement (REM) sleep, and lower mean overnight oxygen saturation [5]. Insomnia is the most common sleep disorder in patients with COPD. Insomnia is defined as difficulty falling sleep and remaining asleep, as well as frequent awakenings during the night. InCould Melatonin Be an Alternative to Benzodiazepine for Chronic Obstructive Pulmonary Disease With Insomnia?
{"title":"Could Melatonin Be an Alternative to Benzodiazepine for Chronic Obstructive Pulmonary Disease With Insomnia?","authors":"Hye Kyeong Park, E. Park","doi":"10.33069/cim.2022.0008","DOIUrl":"https://doi.org/10.33069/cim.2022.0008","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by chronic respiratory symptoms, structural pulmonary abnormalities, and airflow limitation [1]. COPD is highly common and is the third leading cause of death worldwide [2]. Sleep disturbance is one of the most common complaints in patients with COPD, and the presence of sleep disorders further deteriorates their quality of life [3]. Symptom exacerbations are associated with poor sleep quality in patients with COPD [4]. Patients with COPD experience sleep fragmentation with frequent arousals, reduced slow-wave, rapid eye movement (REM) sleep, and lower mean overnight oxygen saturation [5]. Insomnia is the most common sleep disorder in patients with COPD. Insomnia is defined as difficulty falling sleep and remaining asleep, as well as frequent awakenings during the night. InCould Melatonin Be an Alternative to Benzodiazepine for Chronic Obstructive Pulmonary Disease With Insomnia?","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133449169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parkinson’s disease (PD) is a chronic neurodegenerative disorder having various motor and non-motor symptoms in nature. Sleep disturbance is one of major category of non-motor manifestation and exist throughout the disease course from premotor to advanced motor stages in PD. It is essential to understand pathophysiologic basis, etiologies, and clinical presentation of various sleep problems as this is important determinant of quality of life in patients with PD.
{"title":"Sleep Disturbances in Patients with Parkinson’s Disease","authors":"D. Kwon","doi":"10.33069/cim.2022.0004","DOIUrl":"https://doi.org/10.33069/cim.2022.0004","url":null,"abstract":"Parkinson’s disease (PD) is a chronic neurodegenerative disorder having various motor and non-motor symptoms in nature. Sleep disturbance is one of major category of non-motor manifestation and exist throughout the disease course from premotor to advanced motor stages in PD. It is essential to understand pathophysiologic basis, etiologies, and clinical presentation of various sleep problems as this is important determinant of quality of life in patients with PD.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128809022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melatonin and serotonin are endogenous neurotransmitters and hormones produced by tryptophan metabolism. Melatonin and serotonin are present in the heads, eyes, optic lobes, and brains of various invertebrates. Insects produce serotonin and melatonin via the same pathways that vertebrates do. They are pleiotropic signaling chemicals that regulate a wide range of physiological processes and protect against disease and environmental factors in various species. In insects, they function as neurotransmitters, hormones, and bioregulators, controlling a wide range of endocrines, behavioral, immunological, developmental, and defensive activities, as well as biological cycles.
{"title":"Melatonin and Serotonin: Their Synthesis and Effects in Insects","authors":"Mohd Kaleemullah Farooqi, Mohd Ali, M. Amir","doi":"10.33069/cim.2022.0003","DOIUrl":"https://doi.org/10.33069/cim.2022.0003","url":null,"abstract":"Melatonin and serotonin are endogenous neurotransmitters and hormones produced by tryptophan metabolism. Melatonin and serotonin are present in the heads, eyes, optic lobes, and brains of various invertebrates. Insects produce serotonin and melatonin via the same pathways that vertebrates do. They are pleiotropic signaling chemicals that regulate a wide range of physiological processes and protect against disease and environmental factors in various species. In insects, they function as neurotransmitters, hormones, and bioregulators, controlling a wide range of endocrines, behavioral, immunological, developmental, and defensive activities, as well as biological cycles.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131118613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Jung, Eun-Jung Cha, Kyoung Hwan Lee, Seol-Yeon Kim, Doo-Heum Park, J. Ha, H. Jeon, S. Ryu
Objective: The aim of this study was to evaluate whether insomnia can independently affect suicide ideation or whether insomnia affect suicide ideation by mediating depression or anxiety in adjustment disorder (AD). Methods: Electronic medical records were retrospectively reviewed for 65 patients with diagnosed AD visited an outpatient clinic between January 2018 and December 2020. Measurements include the Insomnia Severity Index (ISI), Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory (STAI) and Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Statistical analyses were performed to assess relationship between insomnia and suicide ideation in AD and the mediating role of depression or anxiety in this association. Results: During 3 years of study period, of the AD patients, 37 (57%) were male and 28 (43%) were female. Among them, 45 (69.2%) and 23 (35.4%) had clinically significant symptoms of insomnia (ISI ≥15) and suicide ideation (MMPI scale score ≥70), respectively. In a mediation model using depression and anxiety as mediating variable, there were significant effects of insomnia on depression (t=5.55, p<0.001) and anxiety (t=6.21, p<0.001) and of depression (t=5.70, p<0.001) and anxiety (t=3.54, p<0.001) on suicide ideation. Total effect of insomnia on suicide ideation was statistically insignificant, suggesting complete mediation. Conclusion: A significant association with suicide ideation was observed in the case of insomnia accompanied by depression and anxiety. Therefore, in patients with AD who complain of insomnia, symptoms of depression and anxiety should be evaluated by clinicians with active intervention for suicide ideation.
目的:探讨失眠是否能独立影响自杀意念，或失眠是否通过调节适应障碍(AD)患者的抑郁或焦虑影响自杀意念。方法:回顾性分析2018年1月至2020年12月在门诊就诊的65例诊断为AD的患者的电子病历。测量包括失眠严重指数(ISI)、贝克抑郁量表- ii (BDI-II)、状态-特质焦虑量表(STAI)和明尼苏达多相人格量表-2 (MMPI-2)。通过统计分析评估AD患者失眠与自杀意念之间的关系，以及抑郁或焦虑在这一关联中的中介作用。结果:在3年的研究期间，AD患者中，男性37例(57%)，女性28例(43%)。其中有失眠(ISI≥15)和自杀意念(MMPI量表评分≥70)临床显著症状的分别为45例(69.2%)和23例(35.4%)。在以抑郁和焦虑为中介变量的中介模型中，失眠对抑郁(t=5.55, p<0.001)和焦虑(t=6.21, p<0.001)有显著影响，抑郁(t=5.70, p<0.001)和焦虑(t=3.54, p<0.001)对自杀意念有显著影响。失眠对自杀意念的总影响在统计学上不显著，提示有完全的中介作用。结论:伴有抑郁和焦虑的失眠患者与自杀意念有显著的相关性。因此，对于主诉失眠的AD患者，应由临床医生评估抑郁和焦虑症状，并积极干预自杀意念。
{"title":"Role of Depression and Anxiety As Mediators Between Insomnia Symptoms and Suicide Ideation in Patients With Adjustment Disorder","authors":"K. Jung, Eun-Jung Cha, Kyoung Hwan Lee, Seol-Yeon Kim, Doo-Heum Park, J. Ha, H. Jeon, S. Ryu","doi":"10.33069/cim.2022.0001","DOIUrl":"https://doi.org/10.33069/cim.2022.0001","url":null,"abstract":"Objective: The aim of this study was to evaluate whether insomnia can independently affect suicide ideation or whether insomnia affect suicide ideation by mediating depression or anxiety in adjustment disorder (AD). Methods: Electronic medical records were retrospectively reviewed for 65 patients with diagnosed AD visited an outpatient clinic between January 2018 and December 2020. Measurements include the Insomnia Severity Index (ISI), Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory (STAI) and Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Statistical analyses were performed to assess relationship between insomnia and suicide ideation in AD and the mediating role of depression or anxiety in this association. Results: During 3 years of study period, of the AD patients, 37 (57%) were male and 28 (43%) were female. Among them, 45 (69.2%) and 23 (35.4%) had clinically significant symptoms of insomnia (ISI ≥15) and suicide ideation (MMPI scale score ≥70), respectively. In a mediation model using depression and anxiety as mediating variable, there were significant effects of insomnia on depression (t=5.55, p<0.001) and anxiety (t=6.21, p<0.001) and of depression (t=5.70, p<0.001) and anxiety (t=3.54, p<0.001) on suicide ideation. Total effect of insomnia on suicide ideation was statistically insignificant, suggesting complete mediation. Conclusion: A significant association with suicide ideation was observed in the case of insomnia accompanied by depression and anxiety. Therefore, in patients with AD who complain of insomnia, symptoms of depression and anxiety should be evaluated by clinicians with active intervention for suicide ideation.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"2009 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125628140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Individual’s preferences in time for sleeping, waking up, doing physical and mental activity is dependent on chronotypes. According to these preferences, individuals are categorized to morningness, intermediate, and eveningness chronotype. Recently, it has been suggested that chronotypes are involved in regulation of sleep, appetite, and some metabolic factors. The aim of this study was to investigate the association between chronotypes, obesity, body fat, and lean mass in Tehrani adults.Methods: It was a cross-sectional study on 353 adults aged 18–60 years who referred to Tehran community centers. After anthropometric measurements and collecting data on general information, choronotype, physical activity and 3-day food recalls, fat mass, and lean mass were measured using the method of bioelectrical impedance analysis. SPSS 21 was used to statistical analysis.Results: Of total 353 participants, 11%, 47.6%, and 41.4% had eveningness, intermediate, and morningness chronotypes, respectively. The mean age of individuals with morningness and intermediate was higher than those with eveningness. The prevalence of eveningness in men was higher than in women (p=0.001). Fat mass and lean mass in individuals with eveningness type were higher and lower than those with morningness, respectively (p<0.05). Body mass index and waist circumference showed no significant difference among chronotypes.Conclusion: Eveningness type is associated with increase in fat mass and decrease in lean mass. The effects of chronotype on body fat and lean mass are independent of obesity.
{"title":"Association of Individuals’ Chronotypes With Obesity and Body Composition in Tehrani Adults in 2020","authors":"H. Sadeghzadeh, Mazyar Haghgoo, Samira Rabiei","doi":"10.33069/cim.2021.0032","DOIUrl":"https://doi.org/10.33069/cim.2021.0032","url":null,"abstract":"Objective: Individual’s preferences in time for sleeping, waking up, doing physical and mental activity is dependent on chronotypes. According to these preferences, individuals are categorized to morningness, intermediate, and eveningness chronotype. Recently, it has been suggested that chronotypes are involved in regulation of sleep, appetite, and some metabolic factors. The aim of this study was to investigate the association between chronotypes, obesity, body fat, and lean mass in Tehrani adults.Methods: It was a cross-sectional study on 353 adults aged 18–60 years who referred to Tehran community centers. After anthropometric measurements and collecting data on general information, choronotype, physical activity and 3-day food recalls, fat mass, and lean mass were measured using the method of bioelectrical impedance analysis. SPSS 21 was used to statistical analysis.Results: Of total 353 participants, 11%, 47.6%, and 41.4% had eveningness, intermediate, and morningness chronotypes, respectively. The mean age of individuals with morningness and intermediate was higher than those with eveningness. The prevalence of eveningness in men was higher than in women (p=0.001). Fat mass and lean mass in individuals with eveningness type were higher and lower than those with morningness, respectively (p<0.05). Body mass index and waist circumference showed no significant difference among chronotypes.Conclusion: Eveningness type is associated with increase in fat mass and decrease in lean mass. The effects of chronotype on body fat and lean mass are independent of obesity.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115104918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health Problems With Using Smartphones Late at Night","authors":"Heon-Jeong Lee","doi":"10.33069/cim.2022.0006","DOIUrl":"https://doi.org/10.33069/cim.2022.0006","url":null,"abstract":"","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116842369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Genome-wide association study (GWAS) have led to paradigm shift in the study of psychiatric illnesses. However, GWAS has certain limitations. Thus, investigators have invented the concept of polygenic risk using GWAS. The current study aimed to review the papers on the association between polygenic risk score (PRS) and circadian rhythm. Circadian preferences are indicative of endogenous circadian rhythms. Some studies have revealed that the PRS for circadian preferences is associated with sleep timing, median sleep time, and the risk of bipolar disorder. Moreover, another study revealed that the PRS for diabetes, Alzheimer’s disease, and mood disorders was associated with sleep patterns, wakefulness after sleep onset, and circadian rhythm. In conclusion, the PRS is an anticipated biomarker for predicting diagnosis, treatment response, and clinical outcomes. Thus, PRS will play many roles in personalized medicine soon.
{"title":"Circadian Rhythm and Polygenic Risk Scores","authors":"Young-Min Park","doi":"10.33069/cim.2022.0007","DOIUrl":"https://doi.org/10.33069/cim.2022.0007","url":null,"abstract":"Genome-wide association study (GWAS) have led to paradigm shift in the study of psychiatric illnesses. However, GWAS has certain limitations. Thus, investigators have invented the concept of polygenic risk using GWAS. The current study aimed to review the papers on the association between polygenic risk score (PRS) and circadian rhythm. Circadian preferences are indicative of endogenous circadian rhythms. Some studies have revealed that the PRS for circadian preferences is associated with sleep timing, median sleep time, and the risk of bipolar disorder. Moreover, another study revealed that the PRS for diabetes, Alzheimer’s disease, and mood disorders was associated with sleep patterns, wakefulness after sleep onset, and circadian rhythm. In conclusion, the PRS is an anticipated biomarker for predicting diagnosis, treatment response, and clinical outcomes. Thus, PRS will play many roles in personalized medicine soon.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126522964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The hippocampal neurogenesis in rats has been studied. In addition, when enough activities are provided in daytime, it is suggested that the memory consolidation during sleep will be achieved by hippocampal neurogenesis. We introduce our clinical practice of the chronobiological therapy regarding six dementia cases. Our therapy is based on awakening-sleep rhythm. We performed the medication to promote the changes from sleep to awakening in morning and to stabilize non-REM sleep at night. We also treated the autonomic nervous disorders so that the internal organs became active with Japanese Kampo Medicines, which were integrated with Western medicines. We set our occupational therapy in the daytime. The clinical evaluation was performed by psychological examinations and voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) of MRI. As for Z-score showing the hippocampal atrophy in VSRAD we accomplished the improvement of 0.55 points from 0.03 about six dementia cases by the chronobiological therapy. These improvements were accompanied by the better changes of the cognitive functions. We speculate that the hippocampal neurogenesis may be derived by reconstructing awakening-sleep rhythm.
{"title":"The Clinical Practice for Hippocampal Neurogenesis by Chronobiological Therapy","authors":"M. Shiozawa, Kenjiro Watanabe","doi":"10.33069/cim.2022.0002","DOIUrl":"https://doi.org/10.33069/cim.2022.0002","url":null,"abstract":"The hippocampal neurogenesis in rats has been studied. In addition, when enough activities are provided in daytime, it is suggested that the memory consolidation during sleep will be achieved by hippocampal neurogenesis. We introduce our clinical practice of the chronobiological therapy regarding six dementia cases. Our therapy is based on awakening-sleep rhythm. We performed the medication to promote the changes from sleep to awakening in morning and to stabilize non-REM sleep at night. We also treated the autonomic nervous disorders so that the internal organs became active with Japanese Kampo Medicines, which were integrated with Western medicines. We set our occupational therapy in the daytime. The clinical evaluation was performed by psychological examinations and voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) of MRI. As for Z-score showing the hippocampal atrophy in VSRAD we accomplished the improvement of 0.55 points from 0.03 about six dementia cases by the chronobiological therapy. These improvements were accompanied by the better changes of the cognitive functions. We speculate that the hippocampal neurogenesis may be derived by reconstructing awakening-sleep rhythm.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123917752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study addresses the relationship between Sustainable Development Goals (SDGs) 2030 and artificial light at night (ALAN). In this research paper, different types of SDGs by the United Nations are discussed regarding the effects of ALAN on different goals. In addition, different policies associated with ALAN around the world are examined, and literature reviews are discussed. With this analysis and additional stakeholder discussions, several suggestions are introduced to create a better environment. Regarding different sustainable goals, we observe a trade-off between SDGs and ALAN. It is necessary to discuss different stakeholders, to minimize the negative impact of light pollution and make better policies for the world. One cannot attain SDGs 2030 without considering ALAN. We hope this paper will be helpful to create better policies for sustainable development.
{"title":"An Analysis on How Artificial Light at Night May Impact the Sustainable Development Goals 2030 and Human Health","authors":"Md Shahrukh Jamal, Shahkar Falak, Z. A. Khan","doi":"10.33069/cim.2021.0030","DOIUrl":"https://doi.org/10.33069/cim.2021.0030","url":null,"abstract":"This study addresses the relationship between Sustainable Development Goals (SDGs) 2030 and artificial light at night (ALAN). In this research paper, different types of SDGs by the United Nations are discussed regarding the effects of ALAN on different goals. In addition, different policies associated with ALAN around the world are examined, and literature reviews are discussed. With this analysis and additional stakeholder discussions, several suggestions are introduced to create a better environment. Regarding different sustainable goals, we observe a trade-off between SDGs and ALAN. It is necessary to discuss different stakeholders, to minimize the negative impact of light pollution and make better policies for the world. One cannot attain SDGs 2030 without considering ALAN. We hope this paper will be helpful to create better policies for sustainable development.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"316 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132932165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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