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2022 Systems and Information Engineering Design Symposium (SIEDS)最新文献

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Predicting Liver Utilization Rate and Post- Transplant Outcomes from Donor Text Narratives with Natural Language Processing 用自然语言处理从供体文本叙述预测肝脏利用率和移植后结果
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799424
Kristen J. Bell, Madeline Hennessy, Michael Henry, Avni Malik
Liver transplantation is a critical, life-saving treatment option for patients with terminal liver disease. Despite an organ shortage, many donated livers are discarded for reasons such as poor organ condition and physical incompatibility with a recipient. Current clinical models for liver risk assessment only utilize tabular data and result in poor precision and recall. Critical information relevant to this decision-making is likely included in the free-text clinical notes from donor evaluations that contain pertinent medical and social history of the donor that is currently unavailable in tabular data sources. This article describes the development of a model using these free-text clinical notes using a variety of Natural Language Processing (NLP) and machine learning (ML) techniques to predict the outcomes of three key metrics: 1) liver utilization rate, 2) 30-day mortality rate, and 3) 1-year mortality rate. The free-text narratives were useful for predicting liver utilization, with an associated area under the curve (AUC) score of 0.81, but were not useful for predicting both mortality outcomes, with associated AUC scores of 0.53 and 0.52, for 30-day and 1-year mortality, respectively. Using a locally interpretable model-agnostic explanations (LIME) algorithm, key phrases, like “dcd” and “alcohol” were found to be associated with unutilized livers, while “brain” and “heroin” were associated with utilized livers. Based on these findings, modeling donor text narratives may substantially contribute to improved decision-making and outcomes of liver transplantation.
肝移植对于晚期肝病患者来说是一种至关重要的挽救生命的治疗选择。尽管器官短缺,但由于器官状况不佳和与接受者身体不相容等原因,许多捐赠的肝脏被丢弃。目前肝脏风险评估的临床模型仅使用表格数据,导致准确性和召回率较差。与这一决策有关的关键信息很可能包含在捐助者评价的免费文本临床说明中,其中载有捐助者的相关医疗和社会历史,目前在表格数据来源中无法获得。本文描述了使用各种自然语言处理(NLP)和机器学习(ML)技术使用这些自由文本临床记录的模型的开发,以预测三个关键指标的结果:1)肝脏利用率,2)30天死亡率和3)1年死亡率。自由文本叙述对预测肝脏利用率有用,相关曲线下面积(AUC)评分为0.81,但对预测两种死亡结果无效,30天和1年死亡率的相关AUC评分分别为0.53和0.52。使用局部可解释的模型不可知论解释(LIME)算法,发现关键短语,如“dcd”和“酒精”与未使用的肝脏有关,而“大脑”和“海洛因”与已使用的肝脏有关。基于这些发现,对供体文本叙述进行建模可能会大大有助于改善肝移植的决策和结果。
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引用次数: 0
A neural-network-based forward model to improve air quality estimation from spaceborne polarimeters 基于神经网络的正演模型改进星载偏振计对空气质量的估计
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799366
Abhinay Dommalapati, Anura Ranasinghe, J. Peele, Stephen Whetzel, Michael Jones, A. Bell, E. Chemyakin, S. Stamnes, Heman Shakeri
A growing awareness of the adverse effects of high concentrations of aerosol pollutants on human health [1] motivates the need to accurately measure and forecast the amount of PM2.5 in the air; that is the particulate matter of aerosol particles with size 2.5 microns or less in diameter [2]. Quantifying concentrations of aerosols, particularly near the surface, is foundational to the understanding of the sources, evolution, and transport of PM2.5 and will help to support environmental justice for communities across America and the world. Moreover, developing improved algorithms to accurately invert or retrieve surface-level PM2.5 from satellite remote sensing is critical to improve neighborhood-scale estimates of air quality [3]. In particular, past and future satellite polarimeter and lidar measurements will be key to understanding surface-level PM2.5 conditions in real-time across the globe. A current solution to the retrieval of accurate aerosol properties from satellite polarimeter measurements has been developed by NASA for the Plankton, Aerosols, Clouds and Ecosystems mission (PACE) mission in the form of the Micro-physical Aerosol Properties from Polarimetry (PACE-MAPP) algorithm [4]. However, because solving the vector radiative transfer is numerically intensive, and solving the non-linear inverse problem requires an iterative approach that for multiple channels involves hundreds of vector radiative transfer calls, this approach delivers products at a rate that has latencies too large for and is prohibitively inefficient for the large-scale datasets that will be needed to resolve PM2.5 at neighborhood-scale resolutions of less than 1 km by 1 km. PACE-MAPP solves this problem by developing a neural network framework to replace the complex and time-consuming vector radiative transfer calculations at each iteration. In this study, we apply the PACE-MAPP framework to polarimetry data gathered from the POLDER instrument (PO-Larization and Directionality of the Earth's Reflectances) [5] onboard PARASOL, a satellite that flew from 2006 to 2013 as a part of efforts to understand the effects of clouds and aerosols on the Earth's climate [6] [7], and demonstrate for the first time ever that a neural-network-based approach using coupled atmosphere-ocean vector radiative transfer can be applied to retrieve aerosol properties from satellite polarimeter data, and to take the first step toward evaluating the algorithm's performance at producing air quality products such as PM2.5. We further demonstrate the feasibility of deploying neural networks to solve the numerical inefficiencies that plague satellite polarimeter retrievals while maintaining high accuracy, and expect to cut the speed of acquisition by a factor of 1000.
人们日益认识到高浓度气溶胶污染物对人类健康的不利影响,因此需要准确测量和预测空气中PM2.5的含量;这是直径小于等于2.5微米的气溶胶颗粒。量化气溶胶的浓度,特别是地表附近的气溶胶浓度,是了解PM2.5来源、演变和运输的基础,将有助于支持美国和世界各地社区的环境正义。此外,开发改进的算法,从卫星遥感中准确地反演或检索地表PM2.5,对于改善邻里尺度的空气质量估算至关重要。特别是,过去和未来的卫星偏振仪和激光雷达测量将是实时了解全球地表PM2.5状况的关键。目前,美国宇航局为浮游生物、气溶胶、云和生态系统任务(PACE)开发了一种从卫星偏振仪测量中精确获取气溶胶特性的解决方案,其形式是微物理气溶胶偏振仪特性(PACE- mapp)算法[4]。然而,由于求解矢量辐射传输需要大量的数值计算,而求解非线性逆问题需要一种迭代方法,对于涉及数百个矢量辐射传输调用的多个通道,这种方法提供产品的速度延迟太大,对于以小于1公里× 1公里的邻域尺度分辨率解析PM2.5所需的大规模数据集来说,这种方法的效率非常低。PACE-MAPP通过开发一个神经网络框架来取代每次迭代时复杂且耗时的矢量辐射传递计算,从而解决了这一问题。在本研究中,我们将PACE-MAPP框架应用于从PARASOL卫星上的POLDER仪器收集的偏振数据,该卫星于2006年至2013年飞行,作为了解云和气溶胶对地球气候影响的一部分。并首次证明,利用耦合大气-海洋矢量辐射传输的基于神经网络的方法可以应用于从卫星极化计数据中检索气溶胶特性,并向评估算法在产生PM2.5等空气质量产品方面的性能迈出了第一步。我们进一步证明了部署神经网络的可行性,以解决困扰卫星极化计检索的数值效率低下的问题,同时保持高精度,并期望将采集速度降低1000倍。
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引用次数: 0
A Systematic Approach to Maximizing Search Capabilities for Finding Trapped Survivors in Collapsed Structures 在倒塌建筑物中寻找被困幸存者的最大搜索能力的系统方法
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799346
Emily Aprigliano, Beth Ellinport, Allison Forsyth, H. Rowe
The collapse of the Champlain Tower in Surfside Florida on June 24, 2021 and its subsequent 14-day search and rescue mission caused public and government concerns about the efficiency of urban search and rescue (USAR) strategies. There is, however, no published tool for assessing search findings from a disciplined search methodology, supported by data from USAR missions. Each task force must therefore rely on its own expertise. In this project, we developed a decision support tool prototype that promotes the establishment of a systematic, probability-based strategy to project the survival likelihood for any given area of a collapsed structure. The tool is designed to combine multiple experts' onsite survival probability assessments to assist USAR leaders in making informed decisions about the length and effectiveness of rescue missions based on the unique and evolving factors of a collapse. The probability-based tool is intended to increase the certainty and reduce the time needed for decision makers to conclude that any and all survivors have been found. The time and resources saved by using this tool can then be directed towards other collapse sites or to other post-disaster recovery efforts for the community.
2021年6月24日,佛罗里达州Surfside的尚普兰塔(Champlain Tower)倒塌,以及随后为期14天的搜救任务,引发了公众和政府对城市搜救(USAR)策略效率的担忧。然而,尚无公开的工具来评估由USAR特派团的数据支持的有纪律的搜索方法的搜索结果。因此,每个工作队必须依靠自己的专门知识。在这个项目中,我们开发了一个决策支持工具原型,它促进了一个系统的、基于概率的策略的建立,以预测任何给定区域的倒塌结构的生存可能性。该工具旨在结合多位专家的现场生存概率评估,以帮助USAR领导者根据崩溃的独特和不断变化的因素,就救援任务的长度和有效性做出明智的决策。基于概率的工具旨在增加确定性,并减少决策者得出任何和所有幸存者已被找到的结论所需的时间。使用此工具节省的时间和资源可以用于其他坍塌地点或社区的其他灾后恢复工作。
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引用次数: 0
Design of a Prioritization Methodology for Equitable Infrastructure Planning 公平基础设施规划的优先排序方法设计
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799354
Rahul Dhansinghani, A. Ibrahim, Aditya Kannoth, C. Miller, L. Nguyen, Steven Pham, R. Bailey
Charlottesville City Schools, like many school districts around the country, is interested in expanding the number of children with safe routes to walk to school in response to bus driver shortages. However, there is currently not much walking infrastructure that allows elementary students to do so, and the city would like a way to prioritize infrastructure projects that meet current needs. This project aims to provide decision-makers with a methodology to assess the walkability of school districts in order to prioritize future infrastructure investments. The methodology, built with significant stakeholder involvement, is designed to be transparent to all stakeholders, easy to use, and built on sound decision theory principles while integrating equity in the decision process. The methodology consists of three phases. First, a geospatial information system (GIS) is used to identify areas with the greatest need based on the walkability of roads and socioeconomic factors within communities. Once areas in need have been identified, projects in these areas are compiled. The second step calculates a prioritization score to each project based on the calculated walkability improvement the project will have and how many people will be impacted by the project. The final step visualizes the prioritization score and cost of each project. The methodology was then evaluated against objectives that were determined in collaboration with the primary stakeholders that would be applying the method.
夏洛茨维尔城市学校,像全国许多学区一样,有兴趣扩大有安全路线步行上学的孩子的数量,以应对巴士司机短缺。然而,目前没有太多的步行基础设施允许小学生这样做,市政府希望有一种方式来优先考虑满足当前需求的基础设施项目。该项目旨在为决策者提供一种评估学区步行性的方法,以便优先考虑未来的基础设施投资。该方法建立在重要利益相关者参与的基础上,旨在对所有利益相关者透明,易于使用,并建立在健全的决策理论原则基础上,同时将公平纳入决策过程。该方法包括三个阶段。首先,利用地理空间信息系统(GIS)根据道路的可步行性和社区内的社会经济因素确定最需要的地区。一旦确定了需要的领域,就编制这些领域的项目。第二步计算每个项目的优先级分数,该分数基于计算出的项目将具有的步行改善以及将受项目影响的人数。最后一步可视化每个项目的优先级得分和成本。然后根据与将应用该方法的主要利益相关者合作确定的目标对该方法进行评估。
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引用次数: 0
A Financial Literacy AI-Enabled Voice Assistant System for Educational Use 用于教育用途的金融知识人工智能语音助理系统
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799370
Candace Miu, Jesilyn Gopurathingal, Vineeth Thota, M. Thompson, Niels van Beek, J. Kuczynski, J. Gadewadikar, Tariq Iqbal
Financial literacy is crucial for saving money, avoiding debt, establishing strong credit, and many other skills that help build wealth throughout an individual's life. A very large percentage of Americans from various demographics and backgrounds do not have the basic financial and economic knowledge to sustain themselves financially. Our proposed solution to tackle financial illiteracy is by ensuring students are taught the foundational expertise at a young age so that they make wise financial choices by the time they reach adulthood. We have developed a virtual voice assistant that will improve financial literacy by offering lessons that will cover all topics within the National Standards in K-12 Personal Finance Education educational curricula. Data was collected and analyzed in order to assess the effectiveness, robustness, and engagement of the voice assistant. While further analysis on engagement should be conducted, the bot met baseline goals of effectiveness and robustness which can further be improved through more intent training and testing on potential users.
理财知识对于省钱、避免债务、建立良好的信用以及许多其他帮助个人一生积累财富的技能至关重要。很大一部分来自不同人口统计和背景的美国人没有基本的金融和经济知识来维持自己的财务状况。我们提出的解决金融文盲问题的方案是,确保学生在年轻时接受基础专业知识的教育,以便他们在成年时做出明智的金融选择。我们已经开发了一个虚拟语音助手,通过提供涵盖K-12个人理财教育课程中国家标准中的所有主题的课程,来提高金融知识。收集和分析数据,以评估语音助手的有效性、稳健性和参与度。虽然需要对用户粘性进行进一步的分析,但机器人已经达到了有效性和稳健性的基线目标,可以通过对潜在用户进行更多的意图训练和测试来进一步改进。
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引用次数: 2
Modeling the Implications of Fugitive Gas Emissions on Building Heat Upgrade Decisions 无组织气体排放对建筑热升级决策的影响建模
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799411
Maddie Robinson, Jackson Sompayrac, Nicole Beachy, Hana Sexton, Aidan Jacobs, A. Clarens
The majority of US buildings use natural gas for heating even though it is a potent greenhouse gas that relies on a leaking infrastructure with significant life cycle fugitive emissions. Recent developments in all-electric heating alternatives or ‘certified’ or ‘renewable’ gas alternatives have made decision making about operating building heating systems more complex given quickly evolving emissions and economic profiles. Here, a novel modeling tool was developed to help provide engineers with full cost-accounting of both the economic and greenhouse gas emissions associated with different heating options. The tool is based on the University of Virginia's model for estimating costs and emissions associated with capital expenditures and it was updated with location-specific fugitive emissions and cost estimates. Users can input various different common options for heating systems to understand how much of an impact each will have on economic factors such as return on investment, estimated lifetime cost as well as full-cost life cycle impacts including carbon dioxide-equivalents avoided per year, and life cycle greenhouse gas emissions. The analysis suggests that in most cases it is economically and environmentally preferable to replace gas infrastructure with a heat pump once fugitive emissions are considered. In support of the University of Virginia's net-zero emissions targets, the tool was used to assess several hypothetical heating upgrade projects on grounds including one for Carr's Hill. The tool contains fugitive emissions data for all the major metropolitan areas in the United States and can be easily adopted for use in other locations to provide first-of-its kind information for building managers.
大多数美国建筑使用天然气供暖,尽管天然气是一种强大的温室气体,依赖于泄漏的基础设施,具有大量的生命周期逃逸性排放。考虑到快速发展的排放和经济状况,全电供暖替代方案或“认证”或“可再生”天然气替代方案的最新发展使得有关运行建筑供暖系统的决策变得更加复杂。在这里,开发了一种新颖的建模工具,以帮助工程师对与不同供暖方案相关的经济和温室气体排放进行全面的成本核算。该工具基于弗吉尼亚大学的模型,用于估算与资本支出相关的成本和排放,并根据特定地点的逸散性排放和成本估算进行了更新。用户可以输入供热系统的各种不同的常见选项,以了解每个选项对经济因素的影响程度,如投资回报率、估计寿命成本以及全成本生命周期影响(包括每年避免的二氧化碳当量)和生命周期温室气体排放。分析表明,在大多数情况下,一旦考虑到逸散性排放,用热泵取代天然气基础设施在经济上和环境上都是可取的。为了支持弗吉尼亚大学的净零排放目标,该工具被用于评估几个假设的供暖升级项目,其中包括卡尔山的一个项目。该工具包含美国所有主要大都市地区的逸散排放数据,可以很容易地在其他地方使用,为建筑物管理人员提供同类信息。
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引用次数: 0
Optimization of Patient Flow and Process for a Primary Care Clinic During the COVID-19 Pandemic COVID-19大流行期间初级保健诊所患者流程和流程的优化
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799404
Claire Dozier, Alexandra S. Schmid, Bryce Huffman, Margaret M Cusack, Sarah Saas, Wei Wu, Aram Bahrini, R. Riggs, Kimberly Dowdell, Karen Measells
Many patient throughput inefficiencies result from poor communication practices, inadequate understanding of optimizing healthcare systems to maximize efficiency, and longterm complications caused by the COVID-19 pandemic. The challenges precipitated by the pandemic, combined with the need to provide safe, high-quality care to patients, have further exacerbated existing patient flow and throughput issues. The overarching goal of this project is to improve the patient experience in primary care clinics and reduce the stress placed on providers, nurses, and staff. The authors implemented a two-phased approach that combined qualitative observations with quantitative data analysis, developed a robust methodology for understanding the University Physicians of Charlottesville (UPC) Clinic's processes, and produced structured insights for stakeholders. We established what components comprised a typical patient's journey through system intake through qualitative clinic observations: pre-registration, check-in, and rooming. In contrast to the qualitative observations, the quantitative analysis encompassed the complete patient experience, outs coping to include appointment durations and check-out. All quantitative analyses relied on data from the University of Virginia (UVA) Health's electronic medical record (EMR) system, Epic. In addition to the qualitative analyses, the authors utilized Cadence reports and appointment scheduling data to understand patient flow through the UPC Clinic. Primarily, the data are utilized to understand the distributions between the different patient flow milestones of registration, clinic check-in, rooming, and check-out and what factors, if any, were statistically significant. This approach enabled us to model the distribution of patient arrival times, wait times between arrival and rooming, and other relevant bottlenecks in the flow process.
许多患者吞吐量效率低下的原因是沟通不当、对优化医疗保健系统以最大限度地提高效率的理解不足,以及COVID-19大流行造成的长期并发症。大流行带来的挑战,加上需要向患者提供安全、高质量的护理,进一步加剧了现有的患者流量和吞吐量问题。该项目的总体目标是改善初级保健诊所的患者体验,减轻提供者、护士和工作人员的压力。作者实施了一种两阶段的方法,将定性观察与定量数据分析相结合,开发了一种强大的方法来理解夏洛茨维尔大学医师诊所(UPC)的流程,并为利益相关者提供结构化的见解。通过定性的临床观察,我们确定了典型患者通过系统接收的旅程的组成部分:预登记、登记和分房。与定性观察相比,定量分析包含了完整的患者体验,包括预约持续时间和检查。所有定量分析都依赖于弗吉尼亚大学(UVA)健康电子病历(EMR)系统Epic的数据。除了定性分析外,作者还利用Cadence报告和预约安排数据来了解UPC诊所的患者流量。首先,利用这些数据来了解不同患者流程里程碑(注册、诊所登记、房间和退房)之间的分布,以及哪些因素(如果有的话)具有统计显著性。这种方法使我们能够对患者到达时间的分布、到达和开房之间的等待时间以及流程中的其他相关瓶颈进行建模。
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引用次数: 1
Identifying Challenges in Casting Concrete Artifacts Using 3D Printed Molds 识别在使用3D打印模具浇注混凝土工件的挑战
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799311
R. Jones, Shraddha Joshi, Daniel I. Castaneda
In many engineering fields, it is necessary for engineers to imagine a design and then manifest that design into a physical object. Engineering educators typically engage engineering students who have limited practice in this transference skillset, so we chose to design an instructional project involving casting mortar artifacts using 3D printed molds that students had analytically designed. In preparing this instructional project, we encountered difficulties in casting mortar objects using 3D printed molds that had certain geometries, and we wanted to know what factors in mold geometry contributed to artifact damage during demolding. The scope of this paper focuses on a scholarly project led by an undergraduate research student that explored how the design of 3D printed molds for casting mortar artifacts influenced damage caused during demolding. We designed a series of artifact molds with protrusive features that varied in their aspect ratios and their spatial density to explore how these geometric features contributed toward demolding damage. We experimentally measured the extent of damage by calculating the percent of spike height that was lost during the demolding process. We found that protrusive mold features with large aspect ratios influenced the amount of damage done to those features during demolding. We also found how the spatial density of protrusive features was also a significant cause of damage. From analyzing our data, we identified a clear threshold where mold geometry causes excessive damage during the demolding process. We learned from our scholarly project that casting mortar artifacts with protrusive features in future instructional projects should have surface features designed to be less than a 1:1 aspect ratio to minimize damage during demolding. Understanding these limitations on casting mortar artifacts in 3D printed molds will minimize complications in the instructional project that allows engineering students to analytically design and physically cast artifacts without resulting in excessive damage during demolding.
在许多工程领域,工程师有必要设想一个设计,然后将该设计体现为物理对象。工程教育工作者通常会让那些在这种转移技能方面实践有限的工程学生参与其中,因此我们选择设计一个教学项目,包括使用学生分析设计的3D打印模具铸造砂浆工艺品。在准备这个教学项目时,我们在使用具有特定几何形状的3D打印模具铸造砂浆物体时遇到了困难,我们想知道在脱模过程中模具几何形状中的哪些因素会导致工件损坏。本文的范围集中在一个由本科生领导的学术项目上,该项目探讨了3D打印模具的设计如何影响铸造砂浆工件在脱模过程中造成的损伤。我们设计了一系列具有不同长宽比和空间密度的突出特征的人工制品模具,以探索这些几何特征如何导致脱模损伤。我们通过计算在脱模过程中丢失的钉高的百分比,实验性地测量了损坏的程度。我们发现,在脱模过程中,具有大长宽比的突出模具特征会影响对这些特征的损害程度。我们还发现,突出特征的空间密度也是造成损害的重要原因。通过分析我们的数据,我们确定了一个明确的阈值,即模具几何形状在脱模过程中导致过度损坏。我们从我们的学术项目中了解到,在未来的教学项目中,具有突出特征的铸造砂浆文物的表面特征应设计为小于1:1的纵横比,以尽量减少拆除过程中的损坏。了解在3D打印模具中铸造砂浆工件的这些限制将最大限度地减少教学项目中的复杂性,使工程学生能够分析设计和物理铸造工件,而不会在脱模过程中造成过度损坏。
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引用次数: 0
Quantum Computing and Machine Learning for Efficiency of Maritime Container Port Operations 量子计算和机器学习对海运集装箱港口运营效率的影响
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799399
Ibrahim H. Hamdy, Maxwell J. St. John, Sidney W. Jennings, Tiago R. Magalhaes, James H. Roberts, Thomas L. Polmateer, Mark C. Manasco, Joi Y. Williams, Daniel C. Hendrickson, Timothy L. Eddy, Davis C. Loose, M. Chowdhury, J. Lambert
Maritime container ports are experiencing a variety of challenges, including the pandemic and other stressors, that are altering perspectives on efficiency, risk, and resilience. This study reviews new methods of operations optimization that serve major goals of logistics systems: Increasing energy and time efficiencies and reducing emissions and congestion. Several computational methods will be assessed, including quantum computing, neural networks, and operations heuristics. The methods are compared by potential for increased efficiencies, including the increase in container volumes, reduction of dwell times, reduction of container moves, utilization of demand forecasts, and decreases in emissions. The results suggest opportunities for reinforcement learning to improve the scheduling of container transactions across transportation modes, including maritime, truck, rail, crane, and barge.
海运集装箱港口正在经历各种挑战,包括大流行和其他压力因素,这些挑战正在改变人们对效率、风险和复原力的看法。本研究回顾了服务于物流系统主要目标的操作优化新方法:提高能源和时间效率,减少排放和拥堵。将评估几种计算方法,包括量子计算、神经网络和操作启发式。通过提高效率的潜力对这些方法进行比较,包括增加集装箱体积、减少停留时间、减少集装箱移动、利用需求预测和减少排放。结果表明,强化学习有机会改善跨运输方式(包括海运、卡车、铁路、起重机和驳船)的集装箱交易调度。
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引用次数: 2
Design and Preliminary Testing of a Quadleaflet ePTFE Pediatric Prosthetic Heart Valve 四瓣ePTFE儿童人工心脏瓣膜的设计与初步试验
Pub Date : 2022-04-28 DOI: 10.1109/sieds55548.2022.9799312
Libby H. Welborn, Anna K. Himes, Ida E. Greenlee, Nyna J. DeWitt, Ava T. Burgess, Brandon K. Eberl, O. Pierrakos
In the United States, congenital heart defects affect nearly 40,000 births each year and often will require heart valve replacement [1]. Viable prosthetic heart valve options are limited for pediatric patients that need a valve smaller than 16mm in diameter. When commercially available valve sizes are not available, surgeons often handcraft a valve using expanded polytetrafluoroethylene (ePTFE) to fabricate a valve that is small enough to meet the size constraints of young pediatric patients. There is limited published hemodynamic data for ePTFE valves. A comparison between the two ePTFE handmade valves (trileaflet and quadleaflet) demonstrated hemodynamic differences in regurgitation due to leaflet number. The handmade valves both showed increased regurgitation compared to a Carbomedics valve (commercially available design). Regurgitation had varying effects on pressure gradients and cardiac output. The aim of this paper is to: 1) showcase the design process of a quadleaflet ePTFE valved conduit with a diameter of 16mm or less and 2) offer a hemodynamic performance comparison.
在美国,先天性心脏缺陷每年影响近4万新生儿,通常需要心脏瓣膜置换术[1]。对于需要直径小于16毫米瓣膜的儿科患者,可行的人工心脏瓣膜选择是有限的。当市面上没有瓣膜尺寸时,外科医生通常使用膨胀聚四氟乙烯(ePTFE)手工制作一个足够小的瓣膜,以满足年轻儿科患者的尺寸限制。已发表的ePTFE瓣膜的血流动力学数据有限。两种ePTFE手工瓣膜(三叶瓣和四叶瓣)的比较表明,由于小叶数的不同,反流的血流动力学差异。与碳素瓣膜(市售设计)相比,手工瓣膜的反流都增加了。反流对压力梯度和心输出量有不同的影响。本文的目的是:1)展示直径为16mm或以下的四瓣ePTFE带阀导管的设计过程,2)提供血流动力学性能比较。
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引用次数: 1
期刊
2022 Systems and Information Engineering Design Symposium (SIEDS)
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