Pub Date : 2024-07-25DOI: 10.9734/or/2024/v19i4433
Adil Bouzidi, Mohcine El Mhadi, A. E. Ouafi
Cornea verticillata is caused by the deposition of drugs, metabolic substrates, or disease byproducts in the basal epithelial layer of the cornea, it is most associated with amiodarone and Fabry disease. It can also be caused by a variety of other drugs, the most common of which are: Chloroquine and Hydroxychloroquine, Indomethacin, Phenothiazines. We report two cases of drugs induced cornea verticillata, one secondary to prolonged intake of amiodarone and the other to amiodarone and hydroxychloroquine, to understand its pathophysiology, describe its clinical classification and discuss its treatment. The medications that cause this pathology have similar cationic and amphiphilic characteristics that enable them to penetrate the cornea's basal epithelial layer lysosomes and attach to cellular lipids there. These drug-lipid complexes build up as deposits in the cornea and are resistant to enzymatic breakdown. The deposits are generally not visually significant and generally disappear with the cessation of the causative agent. Several case reports have described resolution of whorled cornea with the use of topical heparin.
{"title":"Drug-induced Cornea Verticillata: A Report of 2 Cases","authors":"Adil Bouzidi, Mohcine El Mhadi, A. E. Ouafi","doi":"10.9734/or/2024/v19i4433","DOIUrl":"https://doi.org/10.9734/or/2024/v19i4433","url":null,"abstract":"Cornea verticillata is caused by the deposition of drugs, metabolic substrates, or disease byproducts in the basal epithelial layer of the cornea, it is most associated with amiodarone and Fabry disease. It can also be caused by a variety of other drugs, the most common of which are: Chloroquine and Hydroxychloroquine, Indomethacin, Phenothiazines. \u0000We report two cases of drugs induced cornea verticillata, one secondary to prolonged intake of amiodarone and the other to amiodarone and hydroxychloroquine, to understand its pathophysiology, describe its clinical classification and discuss its treatment. \u0000The medications that cause this pathology have similar cationic and amphiphilic characteristics that enable them to penetrate the cornea's basal epithelial layer lysosomes and attach to cellular lipids there. These drug-lipid complexes build up as deposits in the cornea and are resistant to enzymatic breakdown. The deposits are generally not visually significant and generally disappear with the cessation of the causative agent. Several case reports have described resolution of whorled cornea with the use of topical heparin.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"48 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.9734/or/2024/v19i4432
Olomola, B. V., Isawumi M. A., Adeoti C. O., E. B. A.
Introduction: The Sustainable Development Goals (SDGs) were adopted at the United Nations (UN) General Assembly in September 2015. The Outcome Document adopted 17 Sustainable Development Goals (SDGs) [2] with 169 targets, ensuring that ‘no one is left behind’ and its importance to eye care. Methodology: Different WHO articles were reviewed, this was then related to eye health in Nigeria. Goals: The seventeen SDGs were related to the eye care services in this write up. This highlights key policy, institutional and regulatory measures put in place to create necessary enabling environment for mainstreaming of SDGs in national policies, plans and programmes, [1] and its coherent coordination. The need for making better use of prevalence data in strategic planning processes for eye care services in Nigeria. Results: From this review of articles it was found out that there was great relationship between the SDGs and the eye. Conclusion: The 2030 Agenda comprises 17 Sustainable Development Goals (SDGs), or Global Goals, which will guide policy and funding for the next 15 years, beginning with a historic pledge to end poverty and to leave no one behind [14].
{"title":"Sustainable Development Goals and Eye Care in Nigeria","authors":"Olomola, B. V., Isawumi M. A., Adeoti C. O., E. B. A.","doi":"10.9734/or/2024/v19i4432","DOIUrl":"https://doi.org/10.9734/or/2024/v19i4432","url":null,"abstract":"Introduction: The Sustainable Development Goals (SDGs) were adopted at the United Nations (UN) General Assembly in September 2015. \u0000The Outcome Document adopted 17 Sustainable Development Goals (SDGs) [2] with 169 targets, ensuring that ‘no one is left behind’ and its importance to eye care. \u0000Methodology: Different WHO articles were reviewed, this was then related to eye health in Nigeria. \u0000Goals: The seventeen SDGs were related to the eye care services in this write up. \u0000This highlights key policy, institutional and regulatory measures put in place to create necessary enabling environment for mainstreaming of SDGs in national policies, plans and programmes, [1] and its coherent coordination. The need for making better use of prevalence data in strategic planning processes for eye care services in Nigeria. \u0000Results: From this review of articles it was found out that there was great relationship between the SDGs and the eye. \u0000Conclusion: The 2030 Agenda comprises 17 Sustainable Development Goals (SDGs), or Global Goals, which will guide policy and funding for the next 15 years, beginning with a historic pledge to end poverty and to leave no one behind [14].","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"66 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.9734/or/2024/v19i4431
Anju Bhaskar, Rajivkumar Gupta
Background: Ocular trauma is preventable and one of the leading causes of ocular morbidity and blindness. Approximately 6 million people are blind from eye injuries, 2.3 million with bilateral visual impairment and 19 million with unilateral visual loss worldwide. In developing countries like ours the incidence of eye injuries is very high. This study has been conducted in the view of public health importance to provide information on magnitude, clinical and epidemiological profile of ocular injuries. Methods: A hospital based, cross sectional observational study, conducted during September 2014 - March 2016 in tertiary care center in Jharkhand, all cases of ocular trauma were included in the study. Demographic profile (age, sex, locality, occupation), nature and cause of injury was recorded. Detailed ophthalmological examination including visual acuity, slit lamp examination, indirect ophthalmoscopy, B-scan, intraocular pressure measurement, gonioscopy, computed tomography brain with orbit, Magnetic Resonance Imaging, X-Ray were done in relevant cases. Results: Total of 948 patients of ocular trauma were included. Most patients belong to the age group 21-40 years (60.87%), with mean age of 29.79 + 16.47 years. Males were affected more (73.52%) than females (26.47%). Closed globe injuries were more (75%) than open globe injuries (25%). Anterior segment was involved in (94.30%) and posterior segment in (8.86%). Work-related ocular injuries formed the commonest mode of injury (41.8%) followed by road traffic accident (30.37%). Conclusion: Ocular trauma is one of the most common causes of unilateral blindness. Targeting groups most at risk with health education, providing effective eye protection and strict implementation of traffic rules may decrease the occurrence of ocular injuries.
{"title":"Clinical Profile of Ocular Trauma at a Tertiary Care Hospital","authors":"Anju Bhaskar, Rajivkumar Gupta","doi":"10.9734/or/2024/v19i4431","DOIUrl":"https://doi.org/10.9734/or/2024/v19i4431","url":null,"abstract":"Background: Ocular trauma is preventable and one of the leading causes of ocular morbidity and blindness. Approximately 6 million people are blind from eye injuries, 2.3 million with bilateral visual impairment and 19 million with unilateral visual loss worldwide. In developing countries like ours the incidence of eye injuries is very high. This study has been conducted in the view of public health importance to provide information on magnitude, clinical and epidemiological profile of ocular injuries. \u0000Methods: A hospital based, cross sectional observational study, conducted during September 2014 - March 2016 in tertiary care center in Jharkhand, all cases of ocular trauma were included in the study. Demographic profile (age, sex, locality, occupation), nature and cause of injury was recorded. Detailed ophthalmological examination including visual acuity, slit lamp examination, indirect ophthalmoscopy, B-scan, intraocular pressure measurement, gonioscopy, computed tomography brain with orbit, Magnetic Resonance Imaging, X-Ray were done in relevant cases. \u0000Results: Total of 948 patients of ocular trauma were included. Most patients belong to the age group 21-40 years (60.87%), with mean age of 29.79 + 16.47 years. Males were affected more (73.52%) than females (26.47%). Closed globe injuries were more (75%) than open globe injuries (25%). Anterior segment was involved in (94.30%) and posterior segment in (8.86%). Work-related ocular injuries formed the commonest mode of injury (41.8%) followed by road traffic accident (30.37%). \u0000Conclusion: Ocular trauma is one of the most common causes of unilateral blindness. Targeting groups most at risk with health education, providing effective eye protection and strict implementation of traffic rules may decrease the occurrence of ocular injuries.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.9734/or/2024/v19i4429
E. Pateras, Α. Chrysanthopoulos
Objective: This study aims to determine the prevalence of accommodation insufficiency among young Caucasian adults in Greece. Methods: Accommodation amplitude was assessed using the minus to blur method (PRA). Results were compared against Donder's and Hofstetter's values. Participants were categorized into "normal," "borderline," and "insufficient" based on deviations from expected values. Results: Over 50% of participants exhibited accommodation insufficiency. Men had significantly lower rates of normal accommodation amplitude compared to women. Further research is required to explore the impact of refractive errors on accommodation issues. Conclusions: Accommodation insufficiency is a significant issue among young adults, necessitating further studies and the establishment of standardized measurement methods. Investigating the role of the ciliary muscle in accommodation is also recommended.
{"title":"Amplitude of Accommodation in Young Caucasian Adults in Greece","authors":"E. Pateras, Α. Chrysanthopoulos","doi":"10.9734/or/2024/v19i4429","DOIUrl":"https://doi.org/10.9734/or/2024/v19i4429","url":null,"abstract":"Objective: This study aims to determine the prevalence of accommodation insufficiency among young Caucasian adults in Greece. \u0000Methods: Accommodation amplitude was assessed using the minus to blur method (PRA). Results were compared against Donder's and Hofstetter's values. Participants were categorized into \"normal,\" \"borderline,\" and \"insufficient\" based on deviations from expected values. \u0000Results: Over 50% of participants exhibited accommodation insufficiency. Men had significantly lower rates of normal accommodation amplitude compared to women. Further research is required to explore the impact of refractive errors on accommodation issues. \u0000Conclusions: Accommodation insufficiency is a significant issue among young adults, necessitating further studies and the establishment of standardized measurement methods. Investigating the role of the ciliary muscle in accommodation is also recommended.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":" 1048","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.9734/or/2024/v19i3428
Anwer S. El-Badry, Eman E. El-Mowafy, Saida M. Amer, Mohamed S. El-Shourbagy, Khalil M. Saad-Allah
Background: Mycotic keratitis (MK) poses a significant risk as a severe and difficult-to-treat corneal infection with potentially life-threatening consequences. Fungi are commonly implicated as causative agents. Additionally, improper care of contact lenses increases the susceptibility to MK. Aim: This study aimed to investigate the phytochemical composition and therapeutic potential of Senna occidentalis ethanolic leaf extract in the treatment of Aspergillus flavus-induced mycotic keratitis. Methodology: The selected plant extract was tested for antimicrobial activity, analyzed for active ingredients and evaluated in vivo for physiological (Kidney and liver functions), histological (corneal tissue healing rates) and immunological responses (IgM levels). Results: The GC/MS analysis revealed high levels of some active components, including o-methyl glucose, tetramethyl hexadecenol, hexadecenoic acid, and octadecatrienoic acid. The ethanolic extract of S. occidentalis demonstrated potent antimicrobial activity against A. flavus in an albino rabbit model. Treatment with the extract at a concentration of 12.5 mg/ml resulted in a significant healing rate without any side effects, as evidenced by reduced levels of blood urea, creatinine, AST, and ALT in infected rabbits. Moreover, S. occidentalis extract effectively stimulated the immune system, as indicated by increased levels of IgM in both infected and non-infected rabbits. Histopathological analysis of the eye cornea further confirmed the complete disappearance of inflammation and restoration of normal tissue appearance and layer arrangement. Conclusions: These findings highlight the potential of S. occidentalis extract as a safe, affordable, and easily accessible treatment for A. flavus-induced mycotic keratitis, owing to its rich content of safe and bioactive phytochemicals.
背景：霉菌性角膜炎（MK）是一种严重且难以治疗的角膜感染，有可能危及生命，因此风险很大。真菌是常见的致病因子。目的：本研究旨在调查番泻叶乙醇叶提取物在治疗黄曲霉菌诱发的霉菌性角膜炎中的植物化学成分和治疗潜力：方法：对所选植物提取物进行抗菌活性测试，分析其有效成分，并在体内进行生理（肾脏和肝脏功能）、组织学（角膜组织愈合率）和免疫学反应（IgM水平）评估：气相色谱/质谱分析显示，一些活性成分的含量很高，包括邻甲基葡萄糖、十四甲基十六烯醇、十六烯酸和十八碳三烯酸。在白化兔模型中，西番莲属植物的乙醇提取物对黄曲霉菌具有很强的抗菌活性。用浓度为 12.5 毫克/毫升的该提取物治疗后，感染兔的血尿素、肌酐、谷草转氨酶和谷丙转氨酶水平均有所下降，表明该提取物具有显著的治愈率，且无任何副作用。此外，S. occidentalis 提取物还能有效刺激免疫系统，感染和未感染兔子的 IgM 水平都有所提高。角膜组织病理学分析进一步证实，炎症完全消失，组织外观和角膜层排列恢复正常：这些研究结果突出表明，由于西洋接骨木果提取物富含安全、生物活性强的植物化学物质，因此具有安全、经济、易于获得的治疗黄曲霉菌引起的霉菌性角膜炎的潜力。
{"title":"Antimicrobial and Immunostimulatory Effects of Senna occidentalis Ethanolic Extract against Aspergillus flavus-Induced Mycotic Keratitis: A Promising Therapeutic Approach","authors":"Anwer S. El-Badry, Eman E. El-Mowafy, Saida M. Amer, Mohamed S. El-Shourbagy, Khalil M. Saad-Allah","doi":"10.9734/or/2024/v19i3428","DOIUrl":"https://doi.org/10.9734/or/2024/v19i3428","url":null,"abstract":"Background: Mycotic keratitis (MK) poses a significant risk as a severe and difficult-to-treat corneal infection with potentially life-threatening consequences. Fungi are commonly implicated as causative agents. Additionally, improper care of contact lenses increases the susceptibility to MK.\u0000Aim: This study aimed to investigate the phytochemical composition and therapeutic potential of Senna occidentalis ethanolic leaf extract in the treatment of Aspergillus flavus-induced mycotic keratitis.\u0000Methodology: The selected plant extract was tested for antimicrobial activity, analyzed for active ingredients and evaluated in vivo for physiological (Kidney and liver functions), histological (corneal tissue healing rates) and immunological responses (IgM levels).\u0000Results: The GC/MS analysis revealed high levels of some active components, including o-methyl glucose, tetramethyl hexadecenol, hexadecenoic acid, and octadecatrienoic acid. The ethanolic extract of S. occidentalis demonstrated potent antimicrobial activity against A. flavus in an albino rabbit model. Treatment with the extract at a concentration of 12.5 mg/ml resulted in a significant healing rate without any side effects, as evidenced by reduced levels of blood urea, creatinine, AST, and ALT in infected rabbits. Moreover, S. occidentalis extract effectively stimulated the immune system, as indicated by increased levels of IgM in both infected and non-infected rabbits. Histopathological analysis of the eye cornea further confirmed the complete disappearance of inflammation and restoration of normal tissue appearance and layer arrangement.\u0000Conclusions: These findings highlight the potential of S. occidentalis extract as a safe, affordable, and easily accessible treatment for A. flavus-induced mycotic keratitis, owing to its rich content of safe and bioactive phytochemicals.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"93 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.9734/or/2024/v19i3427
Nakul Verma, Balbir Khan, V. Anand, Ashneet Sandhu
Two healthy males presented on separate occasions to the emergency room after sustaining trauma by air-gun pellets during farmer’s agitation against the government. Clinical examination indicated that the foreign bodies (air-gun pellets) were imbedded in different locations (subconjunctival and subcutaneous in eye lid.). The management of this traumatic injury is discussed and concurs with the published literature.
{"title":"Two Cases of Ocular Trauma with Air Gun Pellets","authors":"Nakul Verma, Balbir Khan, V. Anand, Ashneet Sandhu","doi":"10.9734/or/2024/v19i3427","DOIUrl":"https://doi.org/10.9734/or/2024/v19i3427","url":null,"abstract":"Two healthy males presented on separate occasions to the emergency room after sustaining trauma by air-gun pellets during farmer’s agitation against the government. Clinical examination indicated that the foreign bodies (air-gun pellets) were imbedded in different locations (subconjunctival and subcutaneous in eye lid.). The management of this traumatic injury is discussed and concurs with the published literature.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-02DOI: 10.9734/or/2024/v19i3426
Hassina S, Bardi S, Cheikhna B, Bekkar B, Bouradouane K, Akkanour Y, Serghini L, Abdalah El
In this article, we highlight the importance of the ophthalmologist in the diagnosis of hypertensive emergencies. It is crucial to know how to make the correct diagnosis and correctly refer the patient. We report a case of a 23-year-old female patient with a history of undocumented nephropathy since the age of 10 years that was admitted for a sudden decrease in visual acuity and persistent headaches that did not respond to pain medication. Diagnosis is often difficult and delayed, the role of the ophthalmologist remains crucial, as our case illustrates. It underlines the urgent need to reduce blood pressure, and highlights the importance of regular follow-up and compliance with treatment to prevent serious complications.
{"title":"Malignant Hypertension: Importance of the Fundus in Emergency Services","authors":"Hassina S, Bardi S, Cheikhna B, Bekkar B, Bouradouane K, Akkanour Y, Serghini L, Abdalah El","doi":"10.9734/or/2024/v19i3426","DOIUrl":"https://doi.org/10.9734/or/2024/v19i3426","url":null,"abstract":"In this article, we highlight the importance of the ophthalmologist in the diagnosis of hypertensive emergencies. It is crucial to know how to make the correct diagnosis and correctly refer the patient. We report a case of a 23-year-old female patient with a history of undocumented nephropathy since the age of 10 years that was admitted for a sudden decrease in visual acuity and persistent headaches that did not respond to pain medication. Diagnosis is often difficult and delayed, the role of the ophthalmologist remains crucial, as our case illustrates. It underlines the urgent need to reduce blood pressure, and highlights the importance of regular follow-up and compliance with treatment to prevent serious complications.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"25 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141272886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.9734/or/2024/v19i3423
A. Apakama, Arinze Anthony Onwuegbuna, C. E. Nwafor, C. C. Uzozie, Fidelis Nkama Isu, A. E. Onyekwe
Aim: To compare the life satisfaction of patients before and after diagnosis of eye pathologies. Methods: This was a prospective cross-sectional survey amongst eye patients at Guinness Eye Centre, Onitsha, South East, Nigeria using pretested interviewer-administered structured questionnaire. Data collected included the socio -demographics and the life satisfaction scores of the patients before, and 4-6 weeks after diagnosis. Results: A total of 137 patients in the age range 18 to 88years, and with disease duration ranging from 1 to 23 years were enrolled. There was equal male to female ratio with mean age of 54.6 years. There was significant decreased mean life satisfaction scores from 25.9 before diagnosis to 24.3 after diagnosis among participants with eye pathology. Conclusion: The diagnosis of a vision threatening eye pathology is associated with lowering of life satisfaction hence the need to incorporate psychotherapy in the long term management of these patients.
{"title":"Comparative Analysis of Life Satisfaction of Patients before and after Diagnosis of Eye Pathologies","authors":"A. Apakama, Arinze Anthony Onwuegbuna, C. E. Nwafor, C. C. Uzozie, Fidelis Nkama Isu, A. E. Onyekwe","doi":"10.9734/or/2024/v19i3423","DOIUrl":"https://doi.org/10.9734/or/2024/v19i3423","url":null,"abstract":"Aim: To compare the life satisfaction of patients before and after diagnosis of eye pathologies.\u0000Methods: This was a prospective cross-sectional survey amongst eye patients at Guinness Eye Centre, Onitsha, South East, Nigeria using pretested interviewer-administered structured questionnaire. Data collected included the socio -demographics and the life satisfaction scores of the patients before, and 4-6 weeks after diagnosis.\u0000Results: A total of 137 patients in the age range 18 to 88years, and with disease duration ranging from 1 to 23 years were enrolled. There was equal male to female ratio with mean age of 54.6 years. There was significant decreased mean life satisfaction scores from 25.9 before diagnosis to 24.3 after diagnosis among participants with eye pathology.\u0000Conclusion: The diagnosis of a vision threatening eye pathology is associated with lowering of life satisfaction hence the need to incorporate psychotherapy in the long term management of these patients.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"18 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-13DOI: 10.9734/or/2024/v19i3422
Z. Hazil, N. Tebay, I. Hasnaoui, A. Krichen, Y. Akannour, L. Serghini, Z. Hajji, B. Ouazzani, E.abdellah.
Bardet–Biedl syndrome (BBS) is a rare autosomal recessive ciliopathy characterized by learning impairments, obesity, post-axial polydactyly, retinal dystrophy, and hypogonadism. Numerous related minor characteristics are crucial for the clinical management of BBS and can aid in the diagnosing process. In 80% of patients, sequencing known disease-causing genes can confirm the diagnosis, which is based on clinical symptoms. BBS genes encode proteins involved in cilia biogenesis and function that localize to the basal body and cilia. Defective cilia resulting from mutations partially explain the pleiotropic effects seen in BBS. We report the case of a 23-year-old patient referred to the nephrology department for progressive bilateral visual acuity loss.
{"title":"Clinical Insights into Bardet-biedl Syndrome and Retinitis Pigmentosa: A Case Report","authors":"Z. Hazil, N. Tebay, I. Hasnaoui, A. Krichen, Y. Akannour, L. Serghini, Z. Hajji, B. Ouazzani, E.abdellah.","doi":"10.9734/or/2024/v19i3422","DOIUrl":"https://doi.org/10.9734/or/2024/v19i3422","url":null,"abstract":"Bardet–Biedl syndrome (BBS) is a rare autosomal recessive ciliopathy characterized by learning impairments, obesity, post-axial polydactyly, retinal dystrophy, and hypogonadism. Numerous related minor characteristics are crucial for the clinical management of BBS and can aid in the diagnosing process. In 80% of patients, sequencing known disease-causing genes can confirm the diagnosis, which is based on clinical symptoms. BBS genes encode proteins involved in cilia biogenesis and function that localize to the basal body and cilia. Defective cilia resulting from mutations partially explain the pleiotropic effects seen in BBS. We report the case of a 23-year-old patient referred to the nephrology department for progressive bilateral visual acuity loss.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-13DOI: 10.9734/or/2024/v19i3421
Z. Hazil, A. Krichen, I. Hasnaoui, S. Hassina, Y. Akannour, L. Seghini, Z. Hajji, B. Ouazzani, E. Abdallah
Non-Hodgkin's lymphomas are malignant tumors whose aggressiveness depends on the histological type of the tumor. The orbital localization may be isolated or associated with a systemic lymphoma. The clinical polymorphism of malignant lymphomas is extreme, posing diagnostic problems and delaying therapeutic management, which is why anatomopathological examination of a tissue biopsy is the only key to diagnosis. We report the case of a patient who presented with exophthalmos revealing a lymphoma.
{"title":"Exophthalmos Revealing Malignant Lymphoma","authors":"Z. Hazil, A. Krichen, I. Hasnaoui, S. Hassina, Y. Akannour, L. Seghini, Z. Hajji, B. Ouazzani, E. Abdallah","doi":"10.9734/or/2024/v19i3421","DOIUrl":"https://doi.org/10.9734/or/2024/v19i3421","url":null,"abstract":"Non-Hodgkin's lymphomas are malignant tumors whose aggressiveness depends on the histological type of the tumor. The orbital localization may be isolated or associated with a systemic lymphoma. \u0000The clinical polymorphism of malignant lymphomas is extreme, posing diagnostic problems and delaying therapeutic management, which is why anatomopathological examination of a tissue biopsy is the only key to diagnosis. \u0000We report the case of a patient who presented with exophthalmos revealing a lymphoma.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"2 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：